INTS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.71369799
2heterochromatin organization (GO:0070828)4.76800184
3nuclear pore organization (GO:0006999)4.70330041
4nuclear pore complex assembly (GO:0051292)4.65857042
5DNA unwinding involved in DNA replication (GO:0006268)4.29743898
6protein localization to kinetochore (GO:0034501)4.24588809
7regulation of translational fidelity (GO:0006450)4.21741190
8regulation of gene silencing by RNA (GO:0060966)4.14751756
9regulation of posttranscriptional gene silencing (GO:0060147)4.14751756
10regulation of gene silencing by miRNA (GO:0060964)4.14751756
11peptidyl-lysine dimethylation (GO:0018027)4.00147523
12regulation of hippo signaling (GO:0035330)3.93104055
13mitotic nuclear envelope disassembly (GO:0007077)3.82414519
14histone H2A monoubiquitination (GO:0035518)3.81805446
15negative regulation of histone methylation (GO:0031061)3.81277079
16folic acid-containing compound biosynthetic process (GO:0009396)3.75193228
17membrane disassembly (GO:0030397)3.70730884
18nuclear envelope disassembly (GO:0051081)3.70730884
19insulin-like growth factor receptor signaling pathway (GO:0048009)3.70109907
20semaphorin-plexin signaling pathway (GO:0071526)3.65864221
21mannose metabolic process (GO:0006013)3.65379033
22regulation of translational termination (GO:0006449)3.60451473
23regulation of RNA export from nucleus (GO:0046831)3.55473347
24histone H4-K12 acetylation (GO:0043983)3.49091550
25paraxial mesoderm development (GO:0048339)3.48221733
26mitotic chromosome condensation (GO:0007076)3.45314566
27NLS-bearing protein import into nucleus (GO:0006607)3.44745891
28regulation of sister chromatid cohesion (GO:0007063)3.42484884
29chromatin assembly (GO:0031497)3.41253945
30sister chromatid segregation (GO:0000819)3.36612635
31COPI coating of Golgi vesicle (GO:0048205)3.34721792
32Golgi transport vesicle coating (GO:0048200)3.34721792
33establishment of apical/basal cell polarity (GO:0035089)3.32254978
34DNA duplex unwinding (GO:0032508)3.31702213
35histone H4-K8 acetylation (GO:0043982)3.30952091
36histone H4-K5 acetylation (GO:0043981)3.30952091
37peptidyl-arginine omega-N-methylation (GO:0035247)3.30392059
38DNA geometric change (GO:0032392)3.27920880
39glucocorticoid receptor signaling pathway (GO:0042921)3.27752090
40planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27335034
41protein localization to chromosome, centromeric region (GO:0071459)3.26888933
42mitotic sister chromatid cohesion (GO:0007064)3.26158355
43pore complex assembly (GO:0046931)3.24871203
44DNA replication-dependent nucleosome organization (GO:0034723)3.24282105
45DNA replication-dependent nucleosome assembly (GO:0006335)3.24282105
46polarized epithelial cell differentiation (GO:0030859)3.24155017
47dosage compensation (GO:0007549)3.23923357
48histone H3-K36 demethylation (GO:0070544)3.23179757
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.21372372
50mitotic sister chromatid segregation (GO:0000070)3.20965500
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.19838714
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17292232
53positive regulation of histone deacetylation (GO:0031065)3.11242379
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09994718
55nuclear envelope organization (GO:0006998)3.09916863
56gene silencing by RNA (GO:0031047)3.06776607
57cytoplasmic mRNA processing body assembly (GO:0033962)3.06598796
58positive regulation of SMAD protein import into nucleus (GO:0060391)3.05753048
59regulation of histone H3-K27 methylation (GO:0061085)3.05392861
60activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.02601235
61intracellular estrogen receptor signaling pathway (GO:0030520)3.02565501
62positive regulation of nuclease activity (GO:0032075)3.02494591
63stress granule assembly (GO:0034063)3.02065118
64gene silencing (GO:0016458)2.99921562
65RNA stabilization (GO:0043489)2.99377562
66mRNA stabilization (GO:0048255)2.99377562
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98886533
68IMP biosynthetic process (GO:0006188)2.98446207
69peptidyl-arginine N-methylation (GO:0035246)2.98082716
70peptidyl-arginine methylation (GO:0018216)2.98082716
71positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.97794971
72mitotic G1 DNA damage checkpoint (GO:0031571)2.97265445
73regulation of ARF protein signal transduction (GO:0032012)2.96049944
74regulation of histone H3-K9 methylation (GO:0051570)2.95745272
75regulation of ARF GTPase activity (GO:0032312)2.95604551
76hippo signaling (GO:0035329)2.95168174
77regulation of nucleobase-containing compound transport (GO:0032239)2.93176552
78trophectodermal cell differentiation (GO:0001829)2.92935005
79maternal placenta development (GO:0001893)2.89914043
80positive regulation of protein kinase C signaling (GO:0090037)2.89885988
81histone lysine demethylation (GO:0070076)2.89539582
82regulation of spindle organization (GO:0090224)2.88753462
83histone arginine methylation (GO:0034969)2.86897217
84regulation of chromatin binding (GO:0035561)2.86818716
85positive regulation of CREB transcription factor activity (GO:0032793)2.86087942
86histone H4-K16 acetylation (GO:0043984)2.86047945
87focal adhesion assembly (GO:0048041)2.85665063
88cell-substrate adherens junction assembly (GO:0007045)2.85665063
89negative regulation of cell size (GO:0045792)2.85537745
90chromatin silencing (GO:0006342)2.84396172
91negative regulation of mRNA metabolic process (GO:1903312)2.82942596
92nucleobase biosynthetic process (GO:0046112)2.82627219
93positive regulation of chromosome segregation (GO:0051984)2.81439466
94positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81229354
95regulation of nuclease activity (GO:0032069)2.80392806
96negative regulation of fatty acid transport (GO:2000192)2.79569133
97anterior/posterior axis specification, embryo (GO:0008595)2.78909317
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.78842955
99establishment of monopolar cell polarity (GO:0061162)2.78842955
100formation of translation preinitiation complex (GO:0001731)2.76539830
101regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.75549930
102regulation of fatty acid beta-oxidation (GO:0031998)2.75448458
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75144461
104regulation of mitotic spindle organization (GO:0060236)2.73534295
105intestinal epithelial cell development (GO:0060576)2.70651400
106histone demethylation (GO:0016577)2.70009396
107histone H2A ubiquitination (GO:0033522)2.67711020
108negative regulation of mRNA processing (GO:0050686)2.66589186
109embryonic foregut morphogenesis (GO:0048617)2.63823542
110protein localization to chromosome (GO:0034502)2.62229037
111positive regulation of RNA splicing (GO:0033120)2.62213322
112nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62018275
113mRNA transport (GO:0051028)2.61780298
114vascular endothelial growth factor signaling pathway (GO:0038084)2.61365204
115ectodermal placode formation (GO:0060788)2.58899992
116adherens junction assembly (GO:0034333)2.58316611
117histone H3-K4 trimethylation (GO:0080182)2.58148330
118negative regulation of RNA splicing (GO:0033119)2.56063121
119regulation of SMAD protein import into nucleus (GO:0060390)2.55587315
120mitotic G1/S transition checkpoint (GO:0044819)2.55358030
121regulation of DNA damage checkpoint (GO:2000001)2.54789033
122regulation of gene silencing (GO:0060968)2.54722040
123activation of Rac GTPase activity (GO:0032863)2.54660374
124corticosteroid receptor signaling pathway (GO:0031958)2.54618381
125histone H3-K9 demethylation (GO:0033169)2.54144146
126negative regulation of erythrocyte differentiation (GO:0045647)2.53733614
127positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.51882574
128endothelial cell chemotaxis (GO:0035767)2.51141233
129lung epithelium development (GO:0060428)2.50600043
130cellular response to epidermal growth factor stimulus (GO:0071364)2.50041517
131negative regulation of myotube differentiation (GO:0010832)2.49829980
132coronary vasculature morphogenesis (GO:0060977)2.46222212
133regulation of NFAT protein import into nucleus (GO:0051532)2.45591827
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.39968744
135positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39403139
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36533676
137ear development (GO:0043583)2.34269741
138regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34046571
139camera-type eye morphogenesis (GO:0048593)2.33956817
140histone H3-K9 modification (GO:0061647)2.33763199
141atrioventricular valve morphogenesis (GO:0003181)2.33490409
142protein dealkylation (GO:0008214)2.33477817
143protein demethylation (GO:0006482)2.33477817
144peptidyl-tyrosine autophosphorylation (GO:0038083)2.32830111
145cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.32684957
146regulation of axon extension involved in axon guidance (GO:0048841)2.32397710
147positive regulation of protein deacetylation (GO:0090312)2.31981937
148cell-substrate junction assembly (GO:0007044)2.31350748
149basement membrane organization (GO:0071711)2.31059039
150cilium or flagellum-dependent cell motility (GO:0001539)2.29371906
151embryonic camera-type eye morphogenesis (GO:0048596)2.28408721
152positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.27744092
153bone trabecula formation (GO:0060346)2.27607271
154Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25589932
155response to epidermal growth factor (GO:0070849)2.24430460
156histone H3-K4 methylation (GO:0051568)2.19183483
157histone H3-K9 methylation (GO:0051567)2.19147343
158cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.18365242
159regulation of endothelial cell chemotaxis (GO:2001026)2.17460876
160negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.17379913
161histone lysine methylation (GO:0034968)2.16838167
162histone H4 deacetylation (GO:0070933)2.15688772
163apoptotic process involved in morphogenesis (GO:0060561)2.15522461
164dermatan sulfate metabolic process (GO:0030205)2.15116534
165eye morphogenesis (GO:0048592)2.13659532
166regulation of establishment of planar polarity (GO:0090175)2.12697153
167embryonic eye morphogenesis (GO:0048048)2.08223316
168cell-cell junction maintenance (GO:0045217)2.08187887
169regulation of fatty acid oxidation (GO:0046320)2.06257915
170glomerular basement membrane development (GO:0032836)2.04146660
171negative regulation of autophagy (GO:0010507)2.04130965
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.04105882
173glomerular epithelial cell development (GO:0072310)2.03629943
174histone H3 deacetylation (GO:0070932)2.03323391
175cell volume homeostasis (GO:0006884)2.02145593
176heart morphogenesis (GO:0003007)2.01400787
177positive regulation of smoothened signaling pathway (GO:0045880)2.00813175
178mesenchyme morphogenesis (GO:0072132)2.00697974
179positive regulation of Rho GTPase activity (GO:0032321)1.98689041
180epithelial cell differentiation involved in prostate gland development (GO:0060742)1.97419820
181regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.97167842
182surfactant homeostasis (GO:0043129)1.96982605
183motile cilium assembly (GO:0044458)1.96825064
184positive regulation of dendrite morphogenesis (GO:0050775)1.96278151
185heart valve formation (GO:0003188)1.96114732
186histone deubiquitination (GO:0016578)1.95561395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87035916
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59642487
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.38097619
4MYC_22102868_ChIP-Seq_BL_Human3.10499281
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84181867
6TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.78147755
7DROSHA_22980978_ChIP-Seq_HELA_Human2.73138967
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52466101
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.51416152
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.50207108
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38282038
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31238429
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26284112
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25455343
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22070776
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20348661
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13446554
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03084419
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02544976
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01114315
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00617736
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.99864144
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.98123985
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95661163
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95480868
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94539752
27* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88683205
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.83897798
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83465667
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82687310
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80901686
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80901686
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80901686
34AR_21909140_ChIP-Seq_LNCAP_Human1.76410540
35ZNF263_19887448_ChIP-Seq_K562_Human1.75198765
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.73787142
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73673800
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73343101
39KDM2B_26808549_Chip-Seq_DND41_Human1.72363907
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69320543
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66999995
42* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66082649
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.65338362
44SMC4_20622854_ChIP-Seq_HELA_Human1.64352394
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63475391
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62192141
47TCF7_22412390_ChIP-Seq_EML_Mouse1.60673897
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59603147
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58034738
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54831255
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51963934
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51954775
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.49876153
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49596163
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.48923914
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47125590
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46813646
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46735486
59AHR_22903824_ChIP-Seq_MCF-7_Human1.46120634
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.46018855
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45367966
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45285599
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44990375
64KDM5A_27292631_Chip-Seq_BREAST_Human1.44936445
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44704513
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43430725
67VDR_21846776_ChIP-Seq_THP-1_Human1.42025863
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41943131
69XRN2_22483619_ChIP-Seq_HELA_Human1.41673272
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39589423
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38900238
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38679401
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37767091
74* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37584240
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37282446
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.36241126
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35855854
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35605290
79* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35252731
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35165503
81ATF3_27146783_Chip-Seq_COLON_Human1.35145747
82* CHD1_26751641_Chip-Seq_LNCaP_Human1.34547200
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34082979
84AR_21572438_ChIP-Seq_LNCaP_Human1.33352596
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32498383
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31063423
87* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29728263
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29637681
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29368710
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29210201
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27372256
92* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26777038
93RACK7_27058665_Chip-Seq_MCF-7_Human1.26670517
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25724407
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25630806
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25466842
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25315634
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25189352
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24779735
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.24689647
101* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23996461
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.23166449
103* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22902763
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22277278
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22193535
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21241385
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.18596402
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18087252
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17974515
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17785124
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16885381
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16612901
113CLOCK_20551151_ChIP-Seq_293T_Human1.15720530
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15542340
115* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15507118
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15475296
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15341132
118CREB1_26743006_Chip-Seq_LNCaP_Human1.14849609
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.13899114
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13268387
121* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13257688
122* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12843081
123KDM2B_26808549_Chip-Seq_K562_Human1.12568032
124TFEB_21752829_ChIP-Seq_HELA_Human1.12409033
125* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12316211
126CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12179349
127EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12176638
128RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12176638
129* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12052792
130LXR_22292898_ChIP-Seq_THP-1_Human1.12006100
131NCOR1_26117541_ChIP-Seq_K562_Human1.11068129
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11041462
133TP63_17297297_ChIP-ChIP_HaCaT_Human1.10652257
134RARB_27405468_Chip-Seq_BRAIN_Mouse1.10605542
135TBX20_22328084_ChIP-Seq_HEART_Mouse1.09870690
136TBX20_22080862_ChIP-Seq_HEART_Mouse1.09870690
137CTCF_27219007_Chip-Seq_Bcells_Human1.08496946
138SA1_27219007_Chip-Seq_ERYTHROID_Human1.08310611
139IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07969490
140TP63_22573176_ChIP-Seq_HFKS_Human1.07578268
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06137425
142SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05022493
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04101848
144EZH2_27294783_Chip-Seq_ESCs_Mouse1.03675544
145P68_20966046_ChIP-Seq_HELA_Human1.02494264
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02472688
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02165901
148TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01353017
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99748110
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98511974
151VDR_24763502_ChIP-Seq_THP-1_Human0.98490704
152* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97937792
153MAF_26560356_Chip-Seq_TH1_Human0.97731674
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97570558
155TP53_22127205_ChIP-Seq_IMR90_Human0.97285343
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.96640481
157SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95836738
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95776239
159* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95431129
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95373089
161ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92848698
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.91895240
163SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90244575
164KLF5_25053715_ChIP-Seq_YYC3_Human0.88863242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.02208458
2MP0010352_gastrointestinal_tract_polyps3.25585257
3MP0003123_paternal_imprinting3.07554423
4MP0005076_abnormal_cell_differentiation3.04671681
5MP0003111_abnormal_nucleus_morphology2.86613596
6MP0002653_abnormal_ependyma_morphology2.75346599
7MP0005503_abnormal_tendon_morphology2.69850032
8MP0004957_abnormal_blastocyst_morpholog2.67366089
9MP0008438_abnormal_cutaneous_collagen2.61012951
10MP0001348_abnormal_lacrimal_gland2.57817303
11MP0003693_abnormal_embryo_hatching2.51631673
12MP0001958_emphysema2.48926640
13MP0001730_embryonic_growth_arrest2.45143780
14MP0003077_abnormal_cell_cycle2.40118729
15MP0003283_abnormal_digestive_organ2.36220718
16MP0002249_abnormal_larynx_morphology2.31180056
17MP0010234_abnormal_vibrissa_follicle2.29584857
18MP0005409_darkened_coat_color2.24385708
19MP0000537_abnormal_urethra_morphology2.23770372
20MP0010094_abnormal_chromosome_stability2.21417962
21MP0009384_cardiac_valve_regurgitation2.19394708
22MP0003121_genomic_imprinting2.18190983
23MP0004264_abnormal_extraembryonic_tissu2.16071424
24MP0003119_abnormal_digestive_system2.15826335
25MP0004858_abnormal_nervous_system2.11935646
26MP0003172_abnormal_lysosome_physiology2.10839561
27MP0002084_abnormal_developmental_patter2.05661837
28MP0000350_abnormal_cell_proliferation2.03851638
29MP0008057_abnormal_DNA_replication1.97476885
30MP0005380_embryogenesis_phenotype1.97399590
31MP0001672_abnormal_embryogenesis/_devel1.97399590
32MP0004197_abnormal_fetal_growth/weight/1.94749291
33MP0003890_abnormal_embryonic-extraembry1.91270069
34MP0002085_abnormal_embryonic_tissue1.90917828
35MP0002086_abnormal_extraembryonic_tissu1.88131673
36MP0002108_abnormal_muscle_morphology1.87464776
37MP0004233_abnormal_muscle_weight1.85902787
38MP0001697_abnormal_embryo_size1.83572668
39MP0002877_abnormal_melanocyte_morpholog1.83467419
40MP0003984_embryonic_growth_retardation1.81421468
41MP0002088_abnormal_embryonic_growth/wei1.80094719
42MP0010307_abnormal_tumor_latency1.79692758
43MP0002009_preneoplasia1.78102700
44MP0000566_synostosis1.73042238
45MP0003122_maternal_imprinting1.71939487
46MP0009780_abnormal_chondrocyte_physiolo1.70609200
47MP0001849_ear_inflammation1.65181441
48MP0002080_prenatal_lethality1.62257159
49MP0009278_abnormal_bone_marrow1.59764833
50MP0008961_abnormal_basal_metabolism1.57464307
51MP0009053_abnormal_anal_canal1.55366159
52MP0004859_abnormal_synaptic_plasticity1.54793358
53MP0010030_abnormal_orbit_morphology1.53489856
54MP0000013_abnormal_adipose_tissue1.52099013
55MP0009672_abnormal_birth_weight1.50602050
56MP0000767_abnormal_smooth_muscle1.49902090
57MP0003566_abnormal_cell_adhesion1.49471619
58MP0008877_abnormal_DNA_methylation1.48369984
59MP0002932_abnormal_joint_morphology1.47019889
60MP0006138_congestive_heart_failure1.42283379
61MP0003567_abnormal_fetal_cardiomyocyte1.41204027
62MP0009703_decreased_birth_body1.37172498
63MP0000383_abnormal_hair_follicle1.37104197
64MP0010368_abnormal_lymphatic_system1.36937229
65MP0003279_aneurysm1.34766927
66MP0000733_abnormal_muscle_development1.34002892
67MP0000751_myopathy1.30408391
68MP0003115_abnormal_respiratory_system1.27734208
69MP0000428_abnormal_craniofacial_morphol1.26279638
70MP0002166_altered_tumor_susceptibility1.25202922
71MP0004381_abnormal_hair_follicle1.24733076
72MP0003787_abnormal_imprinting1.24093747
73MP0005187_abnormal_penis_morphology1.23661618
74MP0008007_abnormal_cellular_replicative1.23394199
75MP0003300_gastrointestinal_ulcer1.21984515
76MP0005275_abnormal_skin_tensile1.21930014
77MP0004130_abnormal_muscle_cell1.21813051
78MP0004185_abnormal_adipocyte_glucose1.20910756
79MP0001293_anophthalmia1.19241813
80MP0000569_abnormal_digit_pigmentation1.18747927
81MP0001661_extended_life_span1.18255377
82MP0002116_abnormal_craniofacial_bone1.17930449
83MP0000534_abnormal_ureter_morphology1.14251683
84MP0005623_abnormal_meninges_morphology1.10916976
85MP0002925_abnormal_cardiovascular_devel1.09517267
86MP0002234_abnormal_pharynx_morphology1.09465646
87MP0003935_abnormal_craniofacial_develop1.07632962
88MP0000003_abnormal_adipose_tissue1.03153622
89MP0008932_abnormal_embryonic_tissue1.03085956
90MP0002168_other_aberrant_phenotype1.00764556
91MP0001299_abnormal_eye_distance/0.98954163
92MP0002697_abnormal_eye_size0.98778085
93MP0010678_abnormal_skin_adnexa0.98500501
94MP0002092_abnormal_eye_morphology0.96733435
95MP0003861_abnormal_nervous_system0.96028270
96MP0001915_intracranial_hemorrhage0.95151715
97MP0002933_joint_inflammation0.94913786
98MP0005023_abnormal_wound_healing0.94715563
99MP0003942_abnormal_urinary_system0.92729905
100MP0001614_abnormal_blood_vessel0.91816843
101MP0001346_abnormal_lacrimal_gland0.91798598
102MP0003045_fibrosis0.89904489
103MP0002060_abnormal_skin_morphology0.89697362
104MP0002896_abnormal_bone_mineralization0.87838797
105MP0008770_decreased_survivor_rate0.87765309
106MP0008058_abnormal_DNA_repair0.87241812
107MP0004133_heterotaxia0.86558253
108MP0000313_abnormal_cell_death0.85315378
109MP0002111_abnormal_tail_morphology0.85245502
110MP0003191_abnormal_cellular_cholesterol0.84633525
111MP0000266_abnormal_heart_morphology0.84586426
112MP0003938_abnormal_ear_development0.84175958
113MP0004272_abnormal_basement_membrane0.83891655
114MP0003950_abnormal_plasma_membrane0.83875456
115MP0003943_abnormal_hepatobiliary_system0.83738109
116MP0005621_abnormal_cell_physiology0.83621381
117MP0002114_abnormal_axial_skeleton0.83546181
118MP0003690_abnormal_glial_cell0.83402455
119MP0000678_abnormal_parathyroid_gland0.81609671
120MP0010630_abnormal_cardiac_muscle0.81002144
121MP0003937_abnormal_limbs/digits/tail_de0.80955632
122MP0001175_abnormal_lung_morphology0.80845793
123MP0004087_abnormal_muscle_fiber0.80261728
124MP0003091_abnormal_cell_migration0.80133704
125MP0002396_abnormal_hematopoietic_system0.79978401
126MP0005384_cellular_phenotype0.79871326
127MP0005670_abnormal_white_adipose0.79825820
128MP0001502_abnormal_circadian_rhythm0.79191853
129MP0003385_abnormal_body_wall0.78252758
130MP0005508_abnormal_skeleton_morphology0.78051893
131MP0000467_abnormal_esophagus_morphology0.77951792
132MP0001270_distended_abdomen0.76780650
133MP0004043_abnormal_pH_regulation0.76538933
134MP0002128_abnormal_blood_circulation0.75896381
135MP0006054_spinal_hemorrhage0.75690193
136MP0002269_muscular_atrophy0.75530422
137MP0005375_adipose_tissue_phenotype0.75339545
138MP0004808_abnormal_hematopoietic_stem0.73439151
139MP0000371_diluted_coat_color0.72527859
140MP0006072_abnormal_retinal_apoptosis0.72265708
141MP0001879_abnormal_lymphatic_vessel0.72156502
142MP0003221_abnormal_cardiomyocyte_apopto0.71505717
143MP0002909_abnormal_adrenal_gland0.70951114
144MP0001784_abnormal_fluid_regulation0.70703267
145MP0005058_abnormal_lysosome_morphology0.70630468
146MP0002089_abnormal_postnatal_growth/wei0.69965370
147MP0005388_respiratory_system_phenotype0.69345684
148MP0002133_abnormal_respiratory_system0.69345684
149MP0005220_abnormal_exocrine_pancreas0.68848023
150MP0003183_abnormal_peptide_metabolism0.68710539
151MP0000759_abnormal_skeletal_muscle0.68409620
152MP0005248_abnormal_Harderian_gland0.68357496
153MP0002019_abnormal_tumor_incidence0.67466761
154MP0000462_abnormal_digestive_system0.66964200
155MP0005666_abnormal_adipose_tissue0.66500072
156MP0004084_abnormal_cardiac_muscle0.66453395
157MP0003329_amyloid_beta_deposits0.66173121
158MP0000432_abnormal_head_morphology0.66114644

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.45929903
2Obstructive sleep apnea (HP:0002870)3.77508031
3Astrocytoma (HP:0009592)3.70387288
4Abnormality of the astrocytes (HP:0100707)3.70387288
5Broad face (HP:0000283)3.44059210
6Abnormality of the lower motor neuron (HP:0002366)3.22830939
7Hyperacusis (HP:0010780)3.12948865
8Cervical subluxation (HP:0003308)3.04020478
9Protrusio acetabuli (HP:0003179)2.91428743
10Glioma (HP:0009733)2.84123780
11Bronchomalacia (HP:0002780)2.80166738
12Renal duplication (HP:0000075)2.71610802
13Biconcave vertebral bodies (HP:0004586)2.66882936
14Cerebral aneurysm (HP:0004944)2.66048567
15Increased nuchal translucency (HP:0010880)2.66043297
16Spinal muscular atrophy (HP:0007269)2.61373842
17Hand muscle atrophy (HP:0009130)2.61291750
18Broad metatarsal (HP:0001783)2.59564116
19Dysmetric saccades (HP:0000641)2.49017660
20Neoplasm of striated muscle (HP:0009728)2.46912308
21Medulloblastoma (HP:0002885)2.45627713
22Neoplasm of the oral cavity (HP:0100649)2.45461260
23Abnormality of the labia minora (HP:0012880)2.43949924
24Flat acetabular roof (HP:0003180)2.43859873
25Rectal prolapse (HP:0002035)2.43319909
26Shallow orbits (HP:0000586)2.39592240
27Bell-shaped thorax (HP:0001591)2.38804490
28Short 4th metacarpal (HP:0010044)2.37704971
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37704971
30Short humerus (HP:0005792)2.33953156
31Volvulus (HP:0002580)2.33076063
32Selective tooth agenesis (HP:0001592)2.31508896
33Upper limb amyotrophy (HP:0009129)2.29861729
34Distal upper limb amyotrophy (HP:0007149)2.29861729
35Macroorchidism (HP:0000053)2.29044393
36Pseudobulbar signs (HP:0002200)2.28862020
37Elfin facies (HP:0004428)2.28149592
38Rhabdomyosarcoma (HP:0002859)2.25773234
39Proximal placement of thumb (HP:0009623)2.25721645
40Deviation of the thumb (HP:0009603)2.24151965
41Thin bony cortex (HP:0002753)2.23642912
42Orthostatic hypotension (HP:0001278)2.22949773
43Shawl scrotum (HP:0000049)2.22933917
44Heterotopia (HP:0002282)2.22197501
45Insomnia (HP:0100785)2.22179383
46Colon cancer (HP:0003003)2.20893154
47Aplasia/hypoplasia of the humerus (HP:0006507)2.19390834
48Aortic aneurysm (HP:0004942)2.19237496
49Renovascular hypertension (HP:0100817)2.18349769
50Neoplasm of the heart (HP:0100544)2.17915710
51Missing ribs (HP:0000921)2.14413782
52Premature rupture of membranes (HP:0001788)2.12224336
53Pointed chin (HP:0000307)2.11526300
54Abnormality of the ischium (HP:0003174)2.10719679
55Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08391444
56Gastrointestinal carcinoma (HP:0002672)2.08282665
57Malignant gastrointestinal tract tumors (HP:0006749)2.08282665
58Dislocated radial head (HP:0003083)2.06933793
59Angiofibromas (HP:0010615)2.06656339
60Adenoma sebaceum (HP:0009720)2.06656339
61Biliary tract neoplasm (HP:0100574)2.06359487
62Ulnar bowing (HP:0003031)2.05932168
63Asymmetry of the thorax (HP:0001555)2.05807816
64Arterial tortuosity (HP:0005116)2.03659273
65Mitral valve prolapse (HP:0001634)2.03385472
66Abnormality of the 4th metacarpal (HP:0010012)2.03346659
67Aortic dissection (HP:0002647)2.03177859
68Overriding aorta (HP:0002623)2.03085740
69Broad thumb (HP:0011304)2.01553381
70Abnormality of the radial head (HP:0003995)1.99955830
71Short 1st metacarpal (HP:0010034)1.99491799
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99491799
73Hypoplastic ischia (HP:0003175)1.99485681
74Vitreoretinal degeneration (HP:0000655)1.97590684
75Genetic anticipation (HP:0003743)1.96540339
76Aortic regurgitation (HP:0001659)1.96185120
77Bowel diverticulosis (HP:0005222)1.95534439
78Aneurysm (HP:0002617)1.94375540
79Facial hemangioma (HP:0000329)1.92959154
80Germ cell neoplasia (HP:0100728)1.91823843
81Turricephaly (HP:0000262)1.91716121
82Hypoplastic labia majora (HP:0000059)1.91348428
83Abnormality of the aortic arch (HP:0012303)1.90572106
84Colitis (HP:0002583)1.89296388
85J-shaped sella turcica (HP:0002680)1.89010044
86Urethral obstruction (HP:0000796)1.87590332
87Abnormality of the fingertips (HP:0001211)1.86198555
88Rib fusion (HP:0000902)1.86134659
89Metaphyseal cupping (HP:0003021)1.85915864
90Vascular tortuosity (HP:0004948)1.85335721
91Persistence of primary teeth (HP:0006335)1.85323388
92Enlarged penis (HP:0000040)1.84811456
93Fibroma (HP:0010614)1.84307639
94Prominent nose (HP:0000448)1.84230956
95Sandal gap (HP:0001852)1.83885681
96Hypopigmentation of the fundus (HP:0007894)1.83633564
97Lip pit (HP:0100267)1.82789973
98Lymphangioma (HP:0100764)1.82423101
99Fibrous tissue neoplasm (HP:0012316)1.82419211
100Anal stenosis (HP:0002025)1.82098494
101Stridor (HP:0010307)1.81837813
102Skin tags (HP:0010609)1.81505797
103Advanced eruption of teeth (HP:0006288)1.81411349
104Short phalanx of the thumb (HP:0009660)1.80855434
105Broad palm (HP:0001169)1.80751202
106Disproportionate tall stature (HP:0001519)1.80639958
107Subacute progressive viral hepatitis (HP:0006572)1.80150674
108Basal cell carcinoma (HP:0002671)1.79145130
109Abnormality of the diencephalon (HP:0010662)1.79043919
110Ankyloglossia (HP:0010296)1.78857392
111Atelectasis (HP:0100750)1.78477791
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.78460617
113Tracheomalacia (HP:0002779)1.77206927
114Pelvic girdle muscle weakness (HP:0003749)1.76145433
115Intestinal polyp (HP:0005266)1.75594112
116Emphysema (HP:0002097)1.75436537
117Morphological abnormality of the middle ear (HP:0008609)1.75317583
118Visceral angiomatosis (HP:0100761)1.73890692
119Bladder diverticulum (HP:0000015)1.72771841
120Hemangiomatosis (HP:0007461)1.72488489
121Intestinal polyposis (HP:0200008)1.71819379
122Abnormality of the salivary glands (HP:0010286)1.71434573
123Overgrowth (HP:0001548)1.71407789
124Male infertility (HP:0003251)1.71107293
125Overlapping toe (HP:0001845)1.70628595
126Narrow palate (HP:0000189)1.70231667
127Abnormality of the labia majora (HP:0012881)1.70122655
128Long eyelashes (HP:0000527)1.70118416
129Atrophic scars (HP:0001075)1.69486538
130Abnormality of the thoracic spine (HP:0100711)1.68978906
131Precocious puberty (HP:0000826)1.68245545
132Obsessive-compulsive behavior (HP:0000722)1.67933594
133Skull defect (HP:0001362)1.66432976
134Tented upper lip vermilion (HP:0010804)1.66403793
135Ankle contracture (HP:0006466)1.66292722
136Cafe-au-lait spot (HP:0000957)1.65896795
137Abnormality of the odontoid process (HP:0003310)1.65854459
138Sparse lateral eyebrow (HP:0005338)1.65704743
139Onion bulb formation (HP:0003383)1.65453019
140Vertebral arch anomaly (HP:0008438)1.65154455
141Broad phalanges of the hand (HP:0009768)1.64984419
142Trigonocephaly (HP:0000243)1.64821546
143Laryngomalacia (HP:0001601)1.64452809
144Genu recurvatum (HP:0002816)1.64329811
145Megalocornea (HP:0000485)1.63608863
146Fragile skin (HP:0001030)1.63581725
147Mitral regurgitation (HP:0001653)1.63073734
148Abnormality of the 1st metacarpal (HP:0010009)1.62746947
149High pitched voice (HP:0001620)1.62475392
150Preauricular skin tag (HP:0000384)1.62128255
151Syringomyelia (HP:0003396)1.62097764
152Spinal cord lesions (HP:0100561)1.62097764
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61890316
154Abnormality of the anterior horn cell (HP:0006802)1.61689141
155Degeneration of anterior horn cells (HP:0002398)1.61689141
156Natal tooth (HP:0000695)1.61456810
157Abnormality of endocrine pancreas physiology (HP:0012093)1.61269652
158Abnormality of the pancreatic islet cells (HP:0006476)1.61269652
159Back pain (HP:0003418)1.60899045
160EMG: neuropathic changes (HP:0003445)1.60602386
161Thin ribs (HP:0000883)1.60100227
162Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59039183
163Interstitial pulmonary disease (HP:0006530)1.58031499
164Deformed sella turcica (HP:0002681)1.57813814
165Dilatation of the ascending aorta (HP:0005111)1.57509722
166Neonatal short-limb short stature (HP:0008921)1.57371308
167Nasal polyposis (HP:0100582)1.57035736
168Camptodactyly of toe (HP:0001836)1.56611890
169Hypoplasia of the odontoid process (HP:0003311)1.56568809
170Flat cornea (HP:0007720)1.53033704
171Smooth philtrum (HP:0000319)1.52699337
172Blue sclerae (HP:0000592)1.52136326
173Joint laxity (HP:0001388)1.51650912
174Long palpebral fissure (HP:0000637)1.50801932
175Abnormal vertebral ossification (HP:0100569)1.49177993
176Neonatal hypoglycemia (HP:0001998)1.47779744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.34928944
2EEF2K3.36512164
3TRIB33.25973734
4PKN22.88224749
5MAP3K102.80696285
6SMG12.72927474
7FGFR42.46717443
8LATS12.36486401
9CDC72.33814692
10PASK2.24975142
11NEK22.20413104
12ICK1.96319895
13LATS21.91722823
14SIK21.90001267
15PDGFRA1.83249074
16MAPK151.77271764
17ALK1.75954064
18NEK11.75228964
19FGFR21.69788450
20MTOR1.67642537
21SCYL21.66727446
22BRD41.66430350
23PTK61.63114022
24MARK21.62239724
25TTK1.57617593
26PRKD31.56459417
27TYRO31.51528085
28RIPK11.51344277
29MAP3K131.48111183
30PRKD21.44297772
31ERN11.43143067
32PAK41.37140631
33FGFR31.33463918
34EPHA21.33189062
35STK101.31642648
36PRPF4B1.26010889
37RPS6KB21.25603146
38WEE11.24368447
39TSSK61.24047235
40CAMK1D1.23293227
41EPHB11.23037384
42MAP3K81.21195496
43CDK71.18180267
44CDK41.16819506
45TAOK11.16819474
46KSR21.16310616
47MST1R1.14914401
48TNK21.12025470
49STK31.11985394
50BUB11.08048725
51BMX1.07706755
52RPS6KA21.06830239
53CHEK11.03903938
54NEK91.01767268
55CDK60.97865455
56CAMK1G0.96973486
57MAP3K90.96824113
58LMTK20.95422794
59PLK10.93443827
60WNK10.91785910
61TTN0.91644879
62LRRK20.90841773
63PTK20.90580626
64PAK20.88423940
65TGFBR10.88098840
66MAPKAPK30.87222834
67TRPM70.86233702
68RIPK40.86018869
69SIK10.85836260
70MAP3K60.85024763
71PAK60.84302840
72MAP2K60.83623964
73CDK20.82939198
74ATR0.82555523
75SGK30.82512809
76KSR10.80130199
77FGFR10.79564824
78PDPK10.77234832
79MAP3K20.76261319
80MAPK110.75131240
81NTRK30.74247794
82MAPK70.74073557
83FLT30.73104602
84CHEK20.72991350
85ERBB20.72334942
86RPS6KL10.72324237
87RPS6KC10.72324237
88AURKB0.70744346
89SGK20.70081071
90AKT30.69603190
91BLK0.68887242
92MAP4K10.68478039
93HIPK20.68367708
94PRKCH0.67838078
95ATM0.67684269
96ZAP700.64436456
97PRKAA20.64321562
98RET0.62942734
99RPS6KA60.62730519
100MAPK120.62588140
101PTK2B0.61381127
102CSNK1E0.58369608
103CDK90.57525182
104RPS6KA40.56021643
105JAK10.55871422
106FER0.55324758
107PDK10.55032488
108CDK10.54613036
109PDGFRB0.54460176
110STK380.53692807
111CDC42BPA0.53541139
112MAP2K30.52942904
113PNCK0.52301150
114SGK2230.51758798
115SGK4940.51758798
116TESK20.51731862
117MAPK80.50997639
118AKT20.50609810
119DYRK1B0.49323007
120DMPK0.49184314
121TYK20.49019070
122PLK30.48520167
123PRKCI0.48481725
124MELK0.47403900
125PRKDC0.46026916
126DDR20.45497650
127DYRK30.45480794
128KIT0.45456623
129MET0.45345645
130NME10.45325555
131EPHA30.45317343
132BRSK20.45050816
133NTRK10.44132236
134CSNK1D0.43493738
135MAPK140.42063555
136AURKA0.41802833
137BRSK10.41570747
138MAPK100.41080685
139MAP2K20.40038139
140GSK3B0.38891680
141JAK30.38735185
142GRK60.38464833
143STK110.38192473
144PRKD10.38190465
145MAP3K70.38024354
146PAK10.37465097
147PRKAA10.37243053
148RPS6KA10.36706093
149MAPK10.36383724
150PRKCZ0.36342412
151CAMKK10.34656012
152DAPK20.34380789
153MAPK30.34360043
154YES10.34294608

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.50413304
2mRNA surveillance pathway_Homo sapiens_hsa030152.14602586
3mTOR signaling pathway_Homo sapiens_hsa041502.11541631
4Cell cycle_Homo sapiens_hsa041102.03391688
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97494709
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93670032
7One carbon pool by folate_Homo sapiens_hsa006701.91225116
8DNA replication_Homo sapiens_hsa030301.88274879
9Spliceosome_Homo sapiens_hsa030401.77783322
10Lysine degradation_Homo sapiens_hsa003101.73392490
11Hippo signaling pathway_Homo sapiens_hsa043901.69883452
12Mismatch repair_Homo sapiens_hsa034301.65491094
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.64582803
14Adherens junction_Homo sapiens_hsa045201.56820115
15Other glycan degradation_Homo sapiens_hsa005111.52224463
16Chronic myeloid leukemia_Homo sapiens_hsa052201.52109819
17Notch signaling pathway_Homo sapiens_hsa043301.48675983
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48241581
19Oocyte meiosis_Homo sapiens_hsa041141.45668854
20MicroRNAs in cancer_Homo sapiens_hsa052061.43647653
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42485846
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41268822
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41156493
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.39567856
25Endometrial cancer_Homo sapiens_hsa052131.35959142
26Basal cell carcinoma_Homo sapiens_hsa052171.35302278
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34921093
28Thyroid cancer_Homo sapiens_hsa052161.33922752
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.32924302
30ABC transporters_Homo sapiens_hsa020101.32786577
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30446599
32ECM-receptor interaction_Homo sapiens_hsa045121.29576050
33Hedgehog signaling pathway_Homo sapiens_hsa043401.26793400
34Bladder cancer_Homo sapiens_hsa052191.24656655
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23352912
36Small cell lung cancer_Homo sapiens_hsa052221.22612209
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21405799
38Proteoglycans in cancer_Homo sapiens_hsa052051.19974920
39Colorectal cancer_Homo sapiens_hsa052101.19628058
40Non-small cell lung cancer_Homo sapiens_hsa052231.18219273
41Base excision repair_Homo sapiens_hsa034101.16925015
42B cell receptor signaling pathway_Homo sapiens_hsa046621.13887024
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.12086425
44Biosynthesis of amino acids_Homo sapiens_hsa012301.10989252
45Viral carcinogenesis_Homo sapiens_hsa052031.09660430
46Type II diabetes mellitus_Homo sapiens_hsa049301.09310159
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08148073
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07569059
49Glioma_Homo sapiens_hsa052141.06540840
50Estrogen signaling pathway_Homo sapiens_hsa049151.05289911
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.04557513
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04374604
53AMPK signaling pathway_Homo sapiens_hsa041521.03384744
54Tight junction_Homo sapiens_hsa045301.03332149
55HTLV-I infection_Homo sapiens_hsa051661.03277280
56Nitrogen metabolism_Homo sapiens_hsa009101.01594955
57Insulin resistance_Homo sapiens_hsa049311.00598130
58Selenocompound metabolism_Homo sapiens_hsa004500.98363982
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98060365
60Renal cell carcinoma_Homo sapiens_hsa052110.97925190
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.96587770
62p53 signaling pathway_Homo sapiens_hsa041150.95407847
63Dorso-ventral axis formation_Homo sapiens_hsa043200.95227291
64Axon guidance_Homo sapiens_hsa043600.92486729
65Focal adhesion_Homo sapiens_hsa045100.91301159
66Insulin signaling pathway_Homo sapiens_hsa049100.90396535
67VEGF signaling pathway_Homo sapiens_hsa043700.89890352
68Prostate cancer_Homo sapiens_hsa052150.89050556
69Long-term potentiation_Homo sapiens_hsa047200.87982197
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.87746270
71Thyroid hormone synthesis_Homo sapiens_hsa049180.87508400
72Gastric acid secretion_Homo sapiens_hsa049710.87252018
73TGF-beta signaling pathway_Homo sapiens_hsa043500.84593979
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83088495
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82606144
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.81674662
77Dilated cardiomyopathy_Homo sapiens_hsa054140.79827902
78Pancreatic cancer_Homo sapiens_hsa052120.79596256
79Hepatitis C_Homo sapiens_hsa051600.78369234
80Amoebiasis_Homo sapiens_hsa051460.78198235
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77654045
82Glucagon signaling pathway_Homo sapiens_hsa049220.77582578
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77150231
84Platelet activation_Homo sapiens_hsa046110.76767098
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75327274
86Nucleotide excision repair_Homo sapiens_hsa034200.75121781
87RNA degradation_Homo sapiens_hsa030180.74916039
88Wnt signaling pathway_Homo sapiens_hsa043100.74474645
89Pathways in cancer_Homo sapiens_hsa052000.74070677
90Bile secretion_Homo sapiens_hsa049760.73921981
91Acute myeloid leukemia_Homo sapiens_hsa052210.70787816
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.70731255
93Cholinergic synapse_Homo sapiens_hsa047250.70250725
94Oxytocin signaling pathway_Homo sapiens_hsa049210.70200721
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.69624492
96Gap junction_Homo sapiens_hsa045400.69421767
97Viral myocarditis_Homo sapiens_hsa054160.69170147
98MAPK signaling pathway_Homo sapiens_hsa040100.68541165
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66322434
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65049821
101HIF-1 signaling pathway_Homo sapiens_hsa040660.64462613
102Ovarian steroidogenesis_Homo sapiens_hsa049130.64334589
103cAMP signaling pathway_Homo sapiens_hsa040240.63703905
104Protein digestion and absorption_Homo sapiens_hsa049740.63090046
105Histidine metabolism_Homo sapiens_hsa003400.62501726
106Insulin secretion_Homo sapiens_hsa049110.62063663
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61851026
108ErbB signaling pathway_Homo sapiens_hsa040120.60575981
109Renin secretion_Homo sapiens_hsa049240.60039842
110N-Glycan biosynthesis_Homo sapiens_hsa005100.59675925
111Prolactin signaling pathway_Homo sapiens_hsa049170.59044700
112Melanogenesis_Homo sapiens_hsa049160.58751273
113Rap1 signaling pathway_Homo sapiens_hsa040150.58441830
114T cell receptor signaling pathway_Homo sapiens_hsa046600.58050596
115FoxO signaling pathway_Homo sapiens_hsa040680.58013883
116Inositol phosphate metabolism_Homo sapiens_hsa005620.57135197
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57059906
118Toxoplasmosis_Homo sapiens_hsa051450.56278211
119Salivary secretion_Homo sapiens_hsa049700.55900169
120Antigen processing and presentation_Homo sapiens_hsa046120.55573609
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55338399
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54348051
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53680857
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.53097502
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.53037507
126Epstein-Barr virus infection_Homo sapiens_hsa051690.52761690
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52691943
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52393260
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51473838
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51430137
131Endocytosis_Homo sapiens_hsa041440.51144945
132Glutamatergic synapse_Homo sapiens_hsa047240.50706799
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50010622
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49598764
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48752822
136GnRH signaling pathway_Homo sapiens_hsa049120.48555878
137Choline metabolism in cancer_Homo sapiens_hsa052310.48514164
138Melanoma_Homo sapiens_hsa052180.47336263
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43824929

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