ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of multicellular organism growth (GO:0040015)	6.01293432
2	sex differentiation (GO:0007548)	5.43327064
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.40491683
4	piRNA metabolic process (GO:0034587)	5.40399487
5	regulation of memory T cell differentiation (GO:0043380)	5.39888615
6	male meiosis I (GO:0007141)	5.11477271
7	cytoplasmic mRNA processing body assembly (GO:0033962)	5.07973262
8	synapsis (GO:0007129)	5.00218514
9	negative regulation of fibroblast apoptotic process (GO:2000270)	4.80080924
10	cilium or flagellum-dependent cell motility (GO:0001539)	4.78399112
11	regulation of MHC class I biosynthetic process (GO:0045343)	4.69686999
12	DNA methylation involved in gamete generation (GO:0043046)	4.54413545
13	meiosis I (GO:0007127)	4.44649079
14	regulation of meiosis I (GO:0060631)	4.21133730
15	male meiosis (GO:0007140)	4.17466588
16	meiotic chromosome segregation (GO:0045132)	4.14714756
17	chromosome organization involved in meiosis (GO:0070192)	4.11999954
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.10129746
19	nucleoside diphosphate catabolic process (GO:0009134)	4.02620243
20	cellular ketone body metabolic process (GO:0046950)	3.92279181
21	regulation of establishment of cell polarity (GO:2000114)	3.85935057
22	kynurenine metabolic process (GO:0070189)	3.81429259
23	axonemal dynein complex assembly (GO:0070286)	3.80269967
24	tryptophan catabolic process (GO:0006569)	3.80024088
25	indole-containing compound catabolic process (GO:0042436)	3.80024088
26	indolalkylamine catabolic process (GO:0046218)	3.80024088
27	gamma-aminobutyric acid transport (GO:0015812)	3.79124140
28	ADP metabolic process (GO:0046031)	3.77057556
29	negative regulation of mast cell activation (GO:0033004)	3.75073000
30	regulation of fibroblast apoptotic process (GO:2000269)	3.74089872
31	sterol catabolic process (GO:0016127)	3.71858309
32	cholesterol catabolic process (GO:0006707)	3.71858309
33	cilium movement (GO:0003341)	3.71707428
34	epithelial cilium movement (GO:0003351)	3.57820479
35	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.56329942
36	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.56329942
37	neurotransmitter-gated ion channel clustering (GO:0072578)	3.54317084
38	synaptonemal complex assembly (GO:0007130)	3.52982908
39	regulation of interleukin-13 production (GO:0032656)	3.51777436
40	cerebellar Purkinje cell differentiation (GO:0021702)	3.50989130
41	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	3.49897676
42	ketone body metabolic process (GO:1902224)	3.42696860
43	photoreceptor cell maintenance (GO:0045494)	3.34480100
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.31753458
45	axoneme assembly (GO:0035082)	3.30429688
46	positive regulation of meiosis (GO:0045836)	3.29006736
47	fucose catabolic process (GO:0019317)	3.28800083
48	L-fucose metabolic process (GO:0042354)	3.28800083
49	L-fucose catabolic process (GO:0042355)	3.28800083
50	microtubule polymerization or depolymerization (GO:0031109)	3.27974818
51	meiotic nuclear division (GO:0007126)	3.27290114
52	synaptonemal complex organization (GO:0070193)	3.26974181
53	reciprocal DNA recombination (GO:0035825)	3.25963897
54	reciprocal meiotic recombination (GO:0007131)	3.25963897
55	meiotic cell cycle process (GO:1903046)	3.21367819
56	bile acid biosynthetic process (GO:0006699)	3.21090922
57	base-excision repair, AP site formation (GO:0006285)	3.20505235
58	indolalkylamine metabolic process (GO:0006586)	3.19015314
59	synaptic transmission, cholinergic (GO:0007271)	3.18221890
60	sulfation (GO:0051923)	3.17171377
61	negative regulation of type 2 immune response (GO:0002829)	3.16942268
62	regulation of cilium movement (GO:0003352)	3.16055754
63	behavioral response to nicotine (GO:0035095)	3.15170732
64	lipid particle organization (GO:0034389)	3.13071802
65	tryptophan metabolic process (GO:0006568)	3.10063940
66	protein-cofactor linkage (GO:0018065)	3.09428666
67	positive regulation of meiotic cell cycle (GO:0051446)	3.07876748
68	acrosome assembly (GO:0001675)	3.06733146
69	regulation of action potential (GO:0098900)	3.03980097
70	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.96379065
71	seminiferous tubule development (GO:0072520)	2.95288900
72	protein polyglutamylation (GO:0018095)	2.93121822
73	detection of light stimulus involved in visual perception (GO:0050908)	2.89449705
74	detection of light stimulus involved in sensory perception (GO:0050962)	2.89449705
75	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.86074774
76	regulation of heat generation (GO:0031650)	2.84573326
77	retinal rod cell development (GO:0046548)	2.83354356
78	cilium morphogenesis (GO:0060271)	2.81155402
79	resolution of meiotic recombination intermediates (GO:0000712)	2.81087615
80	reflex (GO:0060004)	2.79918037
81	central nervous system neuron axonogenesis (GO:0021955)	2.78625738
82	regulation of interleukin-5 production (GO:0032674)	2.76412261
83	positive regulation of vasculogenesis (GO:2001214)	2.75745705
84	behavioral response to ethanol (GO:0048149)	2.74132382
85	adaptation of signaling pathway (GO:0023058)	2.74100777
86	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.71896007
87	neuronal action potential propagation (GO:0019227)	2.71114865
88	estrogen biosynthetic process (GO:0006703)	2.71075559
89	retinal cone cell development (GO:0046549)	2.70173146
90	intraciliary transport (GO:0042073)	2.70161369
91	somite rostral/caudal axis specification (GO:0032525)	2.70048100
92	protein K11-linked deubiquitination (GO:0035871)	2.69046398
93	auditory receptor cell stereocilium organization (GO:0060088)	2.68601422
94	sperm motility (GO:0030317)	2.67186866
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.65781756
96	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.65206474
97	replication fork processing (GO:0031297)	2.64396389
98	auditory behavior (GO:0031223)	2.62555248
99	mechanosensory behavior (GO:0007638)	2.60108058
100	cilium organization (GO:0044782)	2.59145316

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.77634905
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.35952948
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.29710641
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.26960166
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.15204487
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.06221711
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.99225013
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83314472
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64073573
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63533456
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59742923
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55483656
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.45461396
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.30448707
15	FUS_26573619_Chip-Seq_HEK293_Human	2.21084661
16	BCAT_22108803_ChIP-Seq_LS180_Human	2.17407539
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14236068
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02854964
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.99636662
20	P300_19829295_ChIP-Seq_ESCs_Human	1.98386745
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97232942
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79434803
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77311040
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76773553
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74330803
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.74330803
27	STAT3_23295773_ChIP-Seq_U87_Human	1.72193940
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71152868
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.71143963
30	EWS_26573619_Chip-Seq_HEK293_Human	1.70024207
31	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.69126941
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64560080
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62303358
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61856459
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.58517362
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57202055
37	TCF4_23295773_ChIP-Seq_U87_Human	1.56045342
38	AR_25329375_ChIP-Seq_VCAP_Human	1.53392568
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47872123
40	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.46183774
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45098292
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44387831
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40031261
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39284276
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38798405
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38798405
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.38141123
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36481535
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35718351
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35077446
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32534450
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.31391314
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28653164
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28411335
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27213410
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25424569
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25424569
58	CDX2_22108803_ChIP-Seq_LS180_Human	1.24814134
59	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24464136
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23947655
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.23232054
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23027994
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22385926
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21735732
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19111063
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19111063
67	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18910488
68	RXR_22108803_ChIP-Seq_LS180_Human	1.17869954
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16866943
70	KDM2B_26808549_Chip-Seq_REH_Human	1.14501438
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12690623
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12028877
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11626388
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11444212
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11068282
76	NCOR_22424771_ChIP-Seq_293T_Human	1.11061503
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10392511
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10376975
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08569187
80	TBL1_22424771_ChIP-Seq_293T_Human	1.08470622
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07057475
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06128959
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05642228
84	PHF8_20622853_ChIP-Seq_HELA_Human	1.05331713
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04312602
86	AR_20517297_ChIP-Seq_VCAP_Human	1.03252478
87	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03153672
88	NFYB_21822215_ChIP-Seq_K562_Human	1.01934129
89	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.00814259
90	NFYA_21822215_ChIP-Seq_K562_Human	1.00736112
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00614471
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00137342
93	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.99499436
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98523036
95	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95166404
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93522343
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93450235
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93131869
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92810684
100	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92207290

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.34276816
2	MP0002736_abnormal_nociception_after	3.83619078
3	MP0008877_abnormal_DNA_methylation	3.58789291
4	MP0001968_abnormal_touch/_nociception	3.55536954
5	MP0003136_yellow_coat_color	3.33577573
6	MP0003252_abnormal_bile_duct	2.89135577
7	MP0003646_muscle_fatigue	2.48203672
8	MP0002102_abnormal_ear_morphology	2.43780991
9	MP0003195_calcinosis	2.41904164
10	MP0001986_abnormal_taste_sensitivity	2.38086388
11	MP0005551_abnormal_eye_electrophysiolog	2.27887169
12	MP0001501_abnormal_sleep_pattern	2.26475489
13	MP0009745_abnormal_behavioral_response	2.23493732
14	MP0009046_muscle_twitch	2.20532919
15	MP0005410_abnormal_fertilization	2.00064755
16	MP0000427_abnormal_hair_cycle	1.89905854
17	MP0005253_abnormal_eye_physiology	1.88405542
18	MP0005646_abnormal_pituitary_gland	1.83268398
19	MP0008058_abnormal_DNA_repair	1.81051377
20	MP0006072_abnormal_retinal_apoptosis	1.75357172
21	MP0005174_abnormal_tail_pigmentation	1.74077458
22	MP0002210_abnormal_sex_determination	1.74018482
23	MP0003698_abnormal_male_reproductive	1.66182428
24	MP0003011_delayed_dark_adaptation	1.64875588
25	MP0001929_abnormal_gametogenesis	1.62811059
26	MP0005670_abnormal_white_adipose	1.60528251
27	MP0002272_abnormal_nervous_system	1.58786813
28	MP0000383_abnormal_hair_follicle	1.56427639
29	MP0002653_abnormal_ependyma_morphology	1.54678878
30	MP0006276_abnormal_autonomic_nervous	1.49999067
31	MP0001486_abnormal_startle_reflex	1.47956501
32	MP0000653_abnormal_sex_gland	1.47450592
33	MP0001145_abnormal_male_reproductive	1.47330395
34	MP0005171_absent_coat_pigmentation	1.45652701
35	MP0003950_abnormal_plasma_membrane	1.44986554
36	MP0010386_abnormal_urinary_bladder	1.44378064
37	MP0002234_abnormal_pharynx_morphology	1.42193664
38	MP0002733_abnormal_thermal_nociception	1.41697721
39	MP0004147_increased_porphyrin_level	1.35227287
40	MP0002064_seizures	1.34470987
41	MP0008995_early_reproductive_senescence	1.34091923
42	MP0002572_abnormal_emotion/affect_behav	1.33481664
43	MP0010368_abnormal_lymphatic_system	1.32333230
44	MP0004742_abnormal_vestibular_system	1.28034815
45	MP0002735_abnormal_chemical_nociception	1.26041434
46	MP0005310_abnormal_salivary_gland	1.25439991
47	MP0002638_abnormal_pupillary_reflex	1.23249912
48	MP0003119_abnormal_digestive_system	1.23166616
49	MP0001970_abnormal_pain_threshold	1.22532474
50	MP0002928_abnormal_bile_duct	1.20343138
51	MP0005085_abnormal_gallbladder_physiolo	1.17602596
52	MP0002160_abnormal_reproductive_system	1.17397576
53	MP0008872_abnormal_physiological_respon	1.13172879
54	MP0001485_abnormal_pinna_reflex	1.11416350
55	MP0010094_abnormal_chromosome_stability	1.09342337
56	MP0005084_abnormal_gallbladder_morpholo	1.08051978
57	MP0002067_abnormal_sensory_capabilities	1.07985830
58	MP0001529_abnormal_vocalization	1.07203320
59	MP0000631_abnormal_neuroendocrine_gland	1.06109578
60	MP0003635_abnormal_synaptic_transmissio	1.03380204
61	MP0003137_abnormal_impulse_conducting	1.03003487
62	MP0002229_neurodegeneration	1.02925025
63	MP0002557_abnormal_social/conspecific_i	1.02291937
64	MP0006292_abnormal_olfactory_placode	0.98907225
65	MP0003787_abnormal_imprinting	0.98064266
66	MP0005386_behavior/neurological_phenoty	0.97181681
67	MP0004924_abnormal_behavior	0.97181681
68	MP0005647_abnormal_sex_gland	0.96623416
69	MP0000026_abnormal_inner_ear	0.96401225
70	MP0000371_diluted_coat_color	0.95798801
71	MP0001346_abnormal_lacrimal_gland	0.94434362
72	MP0002734_abnormal_mechanical_nocicepti	0.93639463
73	MP0003890_abnormal_embryonic-extraembry	0.92278174
74	MP0003718_maternal_effect	0.91980985
75	MP0002751_abnormal_autonomic_nervous	0.90670615
76	MP0001502_abnormal_circadian_rhythm	0.90523038
77	MP0001963_abnormal_hearing_physiology	0.90004623
78	MP0002063_abnormal_learning/memory/cond	0.89310459
79	MP0002693_abnormal_pancreas_physiology	0.88611049
80	MP0001119_abnormal_female_reproductive	0.87266686
81	MP0005389_reproductive_system_phenotype	0.87031341
82	MP0002161_abnormal_fertility/fecundity	0.84342299
83	MP0005367_renal/urinary_system_phenotyp	0.83509359
84	MP0000516_abnormal_urinary_system	0.83509359
85	MP0004885_abnormal_endolymph	0.82766893
86	MP0001879_abnormal_lymphatic_vessel	0.79789860
87	MP0005645_abnormal_hypothalamus_physiol	0.79642658
88	MP0005365_abnormal_bile_salt	0.79412533
89	MP0003633_abnormal_nervous_system	0.77867515
90	MP0000778_abnormal_nervous_system	0.76160486
91	MP0008961_abnormal_basal_metabolism	0.75437659
92	MP0004130_abnormal_muscle_cell	0.74585775
93	MP0003045_fibrosis	0.73770938
94	MP0005195_abnormal_posterior_eye	0.73269261
95	MP0002163_abnormal_gland_morphology	0.72443586
96	MP0002882_abnormal_neuron_morphology	0.71371183
97	MP0004215_abnormal_myocardial_fiber	0.71074253
98	MP0003936_abnormal_reproductive_system	0.69455657
99	MP0001984_abnormal_olfaction	0.68818412
100	MP0004142_abnormal_muscle_tone	0.68336128

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	5.52820340
2	Progressive cerebellar ataxia (HP:0002073)	5.47377506
3	Hyperventilation (HP:0002883)	4.99786903
4	Gaze-evoked nystagmus (HP:0000640)	4.56625190
5	Action tremor (HP:0002345)	4.53647701
6	Abnormal ciliary motility (HP:0012262)	3.89826568
7	Dysmetric saccades (HP:0000641)	3.86558742
8	Abnormal respiratory motile cilium physiology (HP:0012261)	3.72320909
9	Absent/shortened dynein arms (HP:0200106)	3.61346723
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.61346723
11	Abnormal respiratory motile cilium morphology (HP:0005938)	3.49162636
12	Abnormal respiratory epithelium morphology (HP:0012253)	3.49162636
13	Toxemia of pregnancy (HP:0100603)	3.44079272
14	Pendular nystagmus (HP:0012043)	3.41234404
15	Pancreatic cysts (HP:0001737)	3.32569637
16	Pancreatic fibrosis (HP:0100732)	3.24961379
17	Prostate neoplasm (HP:0100787)	3.12477789
18	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.07854536
19	Attenuation of retinal blood vessels (HP:0007843)	2.98093715
20	Bony spicule pigmentary retinopathy (HP:0007737)	2.96696597
21	Abolished electroretinogram (ERG) (HP:0000550)	2.83621766
22	Abnormality of the hepatic vasculature (HP:0006707)	2.80151311
23	Abnormality of the renal cortex (HP:0011035)	2.71729258
24	Urinary bladder sphincter dysfunction (HP:0002839)	2.69511919
25	Chorioretinal atrophy (HP:0000533)	2.68606287
26	Focal seizures (HP:0007359)	2.68539845
27	True hermaphroditism (HP:0010459)	2.64557140
28	Absence seizures (HP:0002121)	2.62572797
29	Abnormality of midbrain morphology (HP:0002418)	2.60786357
30	Molar tooth sign on MRI (HP:0002419)	2.60786357
31	Impaired vibratory sensation (HP:0002495)	2.57118570
32	Limb hypertonia (HP:0002509)	2.52816719
33	Chronic hepatic failure (HP:0100626)	2.51052096
34	Postural tremor (HP:0002174)	2.48715946
35	Congenital stationary night blindness (HP:0007642)	2.48180349
36	Dysdiadochokinesis (HP:0002075)	2.47884520
37	Febrile seizures (HP:0002373)	2.44334120
38	Dialeptic seizures (HP:0011146)	2.42934341
39	Retinal dysplasia (HP:0007973)	2.40786003
40	Focal motor seizures (HP:0011153)	2.39164391
41	Nephronophthisis (HP:0000090)	2.37703089
42	Bronchiectasis (HP:0002110)	2.37571193
43	Clumsiness (HP:0002312)	2.34951811
44	Increased corneal curvature (HP:0100692)	2.34228198
45	Keratoconus (HP:0000563)	2.34228198
46	Hemiparesis (HP:0001269)	2.29169474
47	Horizontal nystagmus (HP:0000666)	2.27576017
48	Abnormality of the renal medulla (HP:0100957)	2.27153920
49	Postural instability (HP:0002172)	2.25958464
50	Hemiplegia (HP:0002301)	2.25118957
51	Retinitis pigmentosa (HP:0000510)	2.25008569
52	Tubular atrophy (HP:0000092)	2.24406456
53	Decreased central vision (HP:0007663)	2.22970526
54	Sclerocornea (HP:0000647)	2.21521888
55	Rhinitis (HP:0012384)	2.21337832
56	Biliary tract neoplasm (HP:0100574)	2.21149131
57	Generalized aminoaciduria (HP:0002909)	2.18185875
58	Rhabdomyosarcoma (HP:0002859)	2.15929698
59	Thyroid-stimulating hormone excess (HP:0002925)	2.12215277
60	Severe visual impairment (HP:0001141)	2.09924080
61	Abnormal protein glycosylation (HP:0012346)	2.09405074
62	Abnormal glycosylation (HP:0012345)	2.09405074
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09405074
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.09405074
65	Fair hair (HP:0002286)	2.08410276
66	Abnormality of macular pigmentation (HP:0008002)	2.06838704
67	Chromsome breakage (HP:0040012)	2.04752673
68	Supernumerary spleens (HP:0009799)	2.04088002
69	Impaired smooth pursuit (HP:0007772)	2.02630788
70	Medial flaring of the eyebrow (HP:0010747)	2.01002267
71	Proximal tubulopathy (HP:0000114)	1.99254623
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98915767
73	Chronic diarrhea (HP:0002028)	1.98175765
74	Absent speech (HP:0001344)	1.97931731
75	Abnormal rod and cone electroretinograms (HP:0008323)	1.97004358
76	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.95518740
77	Inability to walk (HP:0002540)	1.94590705
78	Cystic liver disease (HP:0006706)	1.93012727
79	Broad-based gait (HP:0002136)	1.92472129
80	Volvulus (HP:0002580)	1.92465057
81	Abnormal biliary tract morphology (HP:0012440)	1.91564531
82	Limb ataxia (HP:0002070)	1.89579338
83	Protruding tongue (HP:0010808)	1.89469559
84	Oculomotor apraxia (HP:0000657)	1.86791885
85	Hyperglycinemia (HP:0002154)	1.84423557
86	Oligodactyly (hands) (HP:0001180)	1.81946057
87	Abnormal drinking behavior (HP:0030082)	1.80364634
88	Polydipsia (HP:0001959)	1.80364634
89	Abnormality of ocular smooth pursuit (HP:0000617)	1.80266992
90	Hypochromic microcytic anemia (HP:0004840)	1.78867718
91	Progressive microcephaly (HP:0000253)	1.77459359
92	Renal cortical cysts (HP:0000803)	1.76018359
93	Widely spaced teeth (HP:0000687)	1.74128669
94	Atonic seizures (HP:0010819)	1.73045006
95	Postaxial foot polydactyly (HP:0001830)	1.70276677
96	Tubulointerstitial nephritis (HP:0001970)	1.69772205
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68718475
98	Agnosia (HP:0010524)	1.65176007
99	Colon cancer (HP:0003003)	1.63632786
100	Infertility (HP:0000789)	1.63092394

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.38073750
2	PNCK	5.02224773
3	CDK19	4.90281178
4	OXSR1	3.28954247
5	BMPR1B	2.26440090
6	CASK	2.16972611
7	WEE1	2.00312076
8	MAP4K2	1.90123266
9	INSRR	1.88121478
10	ZAK	1.75161693
11	ACVR1B	1.73309180
12	TAOK3	1.72297234
13	MAPK15	1.70274637
14	MKNK2	1.62140473
15	TSSK6	1.61690275
16	PLK4	1.61493025
17	BRSK2	1.61040122
18	GRK1	1.53355975
19	ADRBK2	1.46767851
20	TAF1	1.40257166
21	STK38L	1.28304236
22	MET	1.26138077
23	WNK3	1.23530362
24	MAPK13	1.21206026
25	MST4	1.13429891
26	MAP3K7	1.13188282
27	MAP3K4	1.12694561
28	ITK	1.12030554
29	PHKG2	1.10230466
30	PHKG1	1.10230466
31	TNK2	1.09684426
32	EIF2AK3	1.08787317
33	NUAK1	1.07888088
34	PTK2B	1.05910786
35	PINK1	0.96324341
36	TEC	0.96141245
37	MAPKAPK3	0.93428317
38	STK3	0.90135140
39	PLK2	0.88341616
40	PDK2	0.86141379
41	TTK	0.85718242
42	TGFBR1	0.85708116
43	CAMKK2	0.84819921
44	TIE1	0.82668170
45	BCR	0.79738147
46	PKN1	0.79071583
47	CCNB1	0.78469358
48	ERBB2	0.78292792
49	STK38	0.76741930
50	DAPK2	0.74617138
51	FER	0.73476432
52	MKNK1	0.70297228
53	NTRK3	0.70097423
54	MARK1	0.69138775
55	PIK3CG	0.68085530
56	CSNK1G1	0.66724343
57	FGFR2	0.66142608
58	STK11	0.64216031
59	EPHB2	0.63678826
60	STK16	0.61955979
61	PRKCE	0.58688646
62	CDK3	0.58652896
63	PRKAA2	0.56951368
64	CDK8	0.56234197
65	PLK1	0.56039224
66	ADRBK1	0.55982303
67	CSF1R	0.54832407
68	PRKCG	0.51384413
69	STK39	0.51343439
70	CSNK1G3	0.49969495
71	CAMK1G	0.49530907
72	NME1	0.48512657
73	KDR	0.48195916
74	NTRK2	0.47509140
75	NEK1	0.47122864
76	CSNK1G2	0.46858405
77	PASK	0.46056483
78	BMX	0.45106946
79	NLK	0.43695879
80	CHEK2	0.43545397
81	TXK	0.39945765
82	MST1R	0.39889758
83	ROCK1	0.37585527
84	NEK6	0.37003054
85	PIK3CA	0.36876479
86	CHEK1	0.36677451
87	VRK1	0.36277380
88	WNK4	0.35743194
89	MAPKAPK5	0.34571966
90	BRSK1	0.33981619
91	CAMK1	0.33507782
92	CAMK2A	0.32594604
93	PRKG1	0.31245087
94	PAK3	0.31107681
95	WNK1	0.30599076
96	IGF1R	0.30458523
97	PRKCQ	0.30361166
98	BCKDK	0.28991598
99	DYRK2	0.27042551
100	SGK1	0.25847759

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.95560658
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.08241565
3	Propanoate metabolism_Homo sapiens_hsa00640	2.62852300
4	Butanoate metabolism_Homo sapiens_hsa00650	2.44300119
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41497299
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32390525
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30686895
8	Phototransduction_Homo sapiens_hsa04744	2.23513903
9	Homologous recombination_Homo sapiens_hsa03440	2.20839598
10	Olfactory transduction_Homo sapiens_hsa04740	2.12549904
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10301810
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01118567
13	RNA polymerase_Homo sapiens_hsa03020	2.00798015
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.92477080
15	Caffeine metabolism_Homo sapiens_hsa00232	1.87152348
16	Taste transduction_Homo sapiens_hsa04742	1.83528446
17	Nicotine addiction_Homo sapiens_hsa05033	1.81431188
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.64197453
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.62493126
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.60722677
21	ABC transporters_Homo sapiens_hsa02010	1.59166354
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56421738
23	Basal transcription factors_Homo sapiens_hsa03022	1.56092199
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55716389
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.55654672
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.52594979
27	Retinol metabolism_Homo sapiens_hsa00830	1.45177571
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43480235
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33989065
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.33426041
31	Mismatch repair_Homo sapiens_hsa03430	1.24094879
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22213088
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18578347
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14181330
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.12295155
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.11124544
37	Circadian rhythm_Homo sapiens_hsa04710	1.10260785
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09302025
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.08454471
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01532195
41	Peroxisome_Homo sapiens_hsa04146	1.01460735
42	Salivary secretion_Homo sapiens_hsa04970	1.00321325
43	Purine metabolism_Homo sapiens_hsa00230	0.96548784
44	GABAergic synapse_Homo sapiens_hsa04727	0.96371364
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.96093796
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82305765
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.81005454
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80368823
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78555889
50	Morphine addiction_Homo sapiens_hsa05032	0.75080414
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69821229
52	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68101475
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.67775938
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61707408
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.60662552
56	Insulin secretion_Homo sapiens_hsa04911	0.60578995
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.58398271
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.58263864
59	Histidine metabolism_Homo sapiens_hsa00340	0.55453476
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53790046
61	Regulation of autophagy_Homo sapiens_hsa04140	0.53451989
62	Allograft rejection_Homo sapiens_hsa05330	0.53414979
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53091206
64	Huntingtons disease_Homo sapiens_hsa05016	0.52970614
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52201649
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.52140486
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.52072437
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50511894
69	Fatty acid degradation_Homo sapiens_hsa00071	0.49526974
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.49009518
71	Circadian entrainment_Homo sapiens_hsa04713	0.47561608
72	RNA degradation_Homo sapiens_hsa03018	0.46393282
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45907112
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45545252
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45535266
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44404309
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44244178
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43602690
79	Mineral absorption_Homo sapiens_hsa04978	0.42696944
80	Serotonergic synapse_Homo sapiens_hsa04726	0.41252103
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40445278
82	Base excision repair_Homo sapiens_hsa03410	0.40179407
83	Axon guidance_Homo sapiens_hsa04360	0.39721378
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39568612
85	Renin secretion_Homo sapiens_hsa04924	0.38694936
86	Metabolic pathways_Homo sapiens_hsa01100	0.38389528
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38372076
88	Lysine degradation_Homo sapiens_hsa00310	0.37144180
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36355201
90	Oxidative phosphorylation_Homo sapiens_hsa00190	0.36129954
91	Oocyte meiosis_Homo sapiens_hsa04114	0.35396573
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34147408
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.33839795
94	Cell cycle_Homo sapiens_hsa04110	0.32542074
95	Parkinsons disease_Homo sapiens_hsa05012	0.31259824
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30528292
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30206804
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28538255
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28392316
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27651790

INTS4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »