INTS4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urinary tract smooth muscle contraction (GO:0014848)8.77763447
2tachykinin receptor signaling pathway (GO:0007217)7.02695971
3positive regulation of action potential (GO:0045760)6.78873665
4positive regulation of vascular permeability (GO:0043117)6.32438603
5aggressive behavior (GO:0002118)6.22876452
6drinking behavior (GO:0042756)5.76439147
7cell wall macromolecule catabolic process (GO:0016998)5.67552473
8regulation of cilium movement (GO:0003352)5.25286453
9cell wall macromolecule metabolic process (GO:0044036)5.08558323
10regulation of action potential (GO:0098900)5.08014361
11negative regulation of glucose import (GO:0046325)5.05286354
12positive regulation of uterine smooth muscle contraction (GO:0070474)4.95651065
13negative regulation of glucose transport (GO:0010829)4.71228912
14response to auditory stimulus (GO:0010996)4.42445399
15negative regulation of mast cell activation (GO:0033004)4.32747397
16positive regulation of digestive system process (GO:0060456)4.20993758
17positive regulation of synaptic transmission, GABAergic (GO:0032230)4.13080574
18inositol phosphate catabolic process (GO:0071545)4.08074523
19negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.06361164
20regulation of microtubule-based movement (GO:0060632)4.01639067
21motile cilium assembly (GO:0044458)3.92799816
22regulation of centriole replication (GO:0046599)3.79878057
23phosphorylated carbohydrate dephosphorylation (GO:0046838)3.70649038
24inositol phosphate dephosphorylation (GO:0046855)3.70649038
25nonmotile primary cilium assembly (GO:0035058)3.70539595
26regulation of uterine smooth muscle contraction (GO:0070472)3.66165507
27growth hormone secretion (GO:0030252)3.65850380
28heparin biosynthetic process (GO:0030210)3.41648230
29heparin metabolic process (GO:0030202)3.41648230
30righting reflex (GO:0060013)3.40343975
31positive regulation of cGMP biosynthetic process (GO:0030828)3.39833297
32regulation of synaptic transmission, GABAergic (GO:0032228)3.36331088
33cilium movement (GO:0003341)3.34938142
34cellular ketone body metabolic process (GO:0046950)3.34567893
35gamma-aminobutyric acid transport (GO:0015812)3.30369287
36DNA double-strand break processing (GO:0000729)3.27049357
37negative regulation of neurological system process (GO:0031645)3.26040791
38smooth muscle contraction (GO:0006939)3.25685373
39sperm motility (GO:0030317)3.22824195
40synapsis (GO:0007129)3.16408758
41protein polyglutamylation (GO:0018095)3.15695167
42adult feeding behavior (GO:0008343)3.14843898
43polyol catabolic process (GO:0046174)3.14754704
44acrosome reaction (GO:0007340)3.11317779
45tonic smooth muscle contraction (GO:0014820)3.11071102
46microtubule depolymerization (GO:0007019)3.10928829
47regulation of cGMP biosynthetic process (GO:0030826)3.09956459
48neuronal action potential propagation (GO:0019227)3.08565456
49regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07589526
50regulation of Golgi to plasma membrane protein transport (GO:0042996)3.04403437
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04083179
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.04083179
53protein targeting to Golgi (GO:0000042)3.00551515
54microtubule polymerization or depolymerization (GO:0031109)2.98407817
55establishment of protein localization to Golgi (GO:0072600)2.93894272
56protein localization to Golgi apparatus (GO:0034067)2.91305680
57ketone body metabolic process (GO:1902224)2.88146292
58response to morphine (GO:0043278)2.87001069
59positive regulation of cGMP metabolic process (GO:0030825)2.86405835
60behavioral response to ethanol (GO:0048149)2.86081757
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85480352
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84374488
63resolution of meiotic recombination intermediates (GO:0000712)2.83093182
64behavioral response to pain (GO:0048266)2.82423036
65DNA integration (GO:0015074)2.82280327
66response to isoquinoline alkaloid (GO:0014072)2.82171921
67isotype switching (GO:0045190)2.81554504
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.81554504
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.81554504
70metaphase plate congression (GO:0051310)2.78947563
71terpenoid biosynthetic process (GO:0016114)2.77849198
72regulation of centrosome duplication (GO:0010824)2.75595056
73spermatid nucleus differentiation (GO:0007289)2.74000494
74response to pheromone (GO:0019236)2.73952899
75cilium assembly (GO:0042384)2.71178437
76positive regulation of mitochondrial fission (GO:0090141)2.70746555
77brain morphogenesis (GO:0048854)2.70018725
78membrane depolarization during action potential (GO:0086010)2.69158878
79axoneme assembly (GO:0035082)2.68757904
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68698723
81melanosome transport (GO:0032402)2.68603905
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68217844
83regulation of mitotic spindle checkpoint (GO:1903504)2.68217844
84regulation of penile erection (GO:0060405)2.67345445
85detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.67147010
86cilium organization (GO:0044782)2.65925710
87regulation of skeletal muscle contraction (GO:0014819)2.65688280
88striatum development (GO:0021756)2.64434149
89epithelial cilium movement (GO:0003351)2.62962983
90regulation of heat generation (GO:0031650)2.62258718
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62090941
92protein localization to cilium (GO:0061512)2.61509252
93calcium ion import (GO:0070509)2.61276737
94regulation of cGMP metabolic process (GO:0030823)2.57598085
95calcium ion-dependent exocytosis (GO:0017156)2.57098564
96C4-dicarboxylate transport (GO:0015740)2.55968785
97diterpenoid biosynthetic process (GO:0016102)2.55925977
98sequestering of actin monomers (GO:0042989)2.55823317
99regulation of feeding behavior (GO:0060259)2.54920919
100positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.54456308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.90858366
2ZNF274_21170338_ChIP-Seq_K562_Hela3.33945620
3VDR_22108803_ChIP-Seq_LS180_Human3.32383178
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07053871
5EZH2_22144423_ChIP-Seq_EOC_Human3.00305880
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.94814506
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70230494
8FUS_26573619_Chip-Seq_HEK293_Human2.70109361
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.69442726
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57372861
11TAF15_26573619_Chip-Seq_HEK293_Human2.56844471
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44137352
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43872202
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37378867
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20060717
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18905300
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17490052
18IGF1R_20145208_ChIP-Seq_DFB_Human2.16559661
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09789413
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08968004
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95492887
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93355599
23SMAD4_21799915_ChIP-Seq_A2780_Human1.89674668
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80171697
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78930756
26EWS_26573619_Chip-Seq_HEK293_Human1.75761605
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72293435
28CBP_20019798_ChIP-Seq_JUKART_Human1.71581444
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71581444
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70926733
31STAT3_23295773_ChIP-Seq_U87_Human1.69067343
32P300_19829295_ChIP-Seq_ESCs_Human1.63611882
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60254555
34AR_21572438_ChIP-Seq_LNCaP_Human1.56839615
35ER_23166858_ChIP-Seq_MCF-7_Human1.55472755
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.54416825
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.53404728
38TCF4_23295773_ChIP-Seq_U87_Human1.52803447
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52760007
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52725588
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44191742
42TP53_22573176_ChIP-Seq_HFKS_Human1.39479662
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36298254
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35329710
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.34740996
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.32872394
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31424110
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.30564167
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30225108
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.29523452
51ELK1_19687146_ChIP-ChIP_HELA_Human1.28256486
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.28224079
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28070452
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27511661
55TP53_16413492_ChIP-PET_HCT116_Human1.27379806
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24900735
57TCF4_22108803_ChIP-Seq_LS180_Human1.24037354
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23414266
59RUNX2_22187159_ChIP-Seq_PCA_Human1.22960281
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22920710
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21236686
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.14895477
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14047549
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14047549
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13344154
66BCAT_22108803_ChIP-Seq_LS180_Human1.12831201
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.12234723
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11510654
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11320075
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10664309
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10563042
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10039884
73P53_22387025_ChIP-Seq_ESCs_Mouse1.09869546
74RNF2_27304074_Chip-Seq_NSC_Mouse1.09552553
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08574105
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.08533560
77AR_25329375_ChIP-Seq_VCAP_Human1.08455832
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07591373
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07313244
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07309553
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.07243958
82SALL4_22934838_ChIP-ChIP_CD34+_Human1.05927799
83NANOG_19829295_ChIP-Seq_ESCs_Human1.05713368
84SOX2_19829295_ChIP-Seq_ESCs_Human1.05713368
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04323037
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.02937305
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02576550
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02499246
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.02076619
90CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01583007
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.00811034
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99034651
93SOX9_26525672_Chip-Seq_HEART_Mouse0.97474209
94TBL1_22424771_ChIP-Seq_293T_Human0.96232719
95ETV1_20927104_ChIP-Seq_GIST48_Human0.95254799
96P300_18555785_Chip-Seq_ESCs_Mouse0.95083550
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.94880725
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94540737
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93726167
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.93617304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after5.94252865
2MP0002735_abnormal_chemical_nociception4.84075701
3MP0001968_abnormal_touch/_nociception4.58948142
4MP0002822_catalepsy4.01452122
5MP0001529_abnormal_vocalization3.97141471
6MP0003718_maternal_effect2.92053076
7MP0004145_abnormal_muscle_electrophysio2.70992398
8MP0002653_abnormal_ependyma_morphology2.64025860
9MP0001984_abnormal_olfaction2.55346796
10MP0002734_abnormal_mechanical_nocicepti2.25965530
11MP0009780_abnormal_chondrocyte_physiolo2.17841706
12MP0005670_abnormal_white_adipose2.15834856
13MP0005410_abnormal_fertilization2.07627254
14MP0000569_abnormal_digit_pigmentation1.79351220
15MP0002102_abnormal_ear_morphology1.71474253
16MP0009745_abnormal_behavioral_response1.69762894
17MP0003880_abnormal_central_pattern1.67939539
18MP0009046_muscle_twitch1.62906950
19MP0002277_abnormal_respiratory_mucosa1.56651591
20MP0005395_other_phenotype1.54747606
21MP0004215_abnormal_myocardial_fiber1.53808197
22MP0005646_abnormal_pituitary_gland1.53707877
23MP0002751_abnormal_autonomic_nervous1.52712050
24MP0005551_abnormal_eye_electrophysiolog1.51073792
25MP0005253_abnormal_eye_physiology1.50598710
26MP0002572_abnormal_emotion/affect_behav1.50187082
27MP0008872_abnormal_physiological_respon1.48522229
28MP0003787_abnormal_imprinting1.48154054
29MP0001661_extended_life_span1.44834622
30MP0002909_abnormal_adrenal_gland1.41531649
31MP0001970_abnormal_pain_threshold1.40715498
32MP0005171_absent_coat_pigmentation1.38498465
33MP0004043_abnormal_pH_regulation1.37786921
34MP0004859_abnormal_synaptic_plasticity1.37671840
35MP0004270_analgesia1.35121219
36MP0004142_abnormal_muscle_tone1.35024741
37MP0004134_abnormal_chest_morphology1.33283483
38MP0002272_abnormal_nervous_system1.30421322
39MP0000462_abnormal_digestive_system1.30006858
40MP0002938_white_spotting1.27604466
41MP0002067_abnormal_sensory_capabilities1.27059881
42MP0005248_abnormal_Harderian_gland1.25878069
43MP0002063_abnormal_learning/memory/cond1.24781449
44MP0001486_abnormal_startle_reflex1.24302254
45MP0003635_abnormal_synaptic_transmissio1.18629426
46MP0005394_taste/olfaction_phenotype1.15124195
47MP0005499_abnormal_olfactory_system1.15124195
48MP0000013_abnormal_adipose_tissue1.13563703
49MP0008789_abnormal_olfactory_epithelium1.12977946
50MP0005075_abnormal_melanosome_morpholog1.11070726
51MP0003633_abnormal_nervous_system1.10827468
52MP0006276_abnormal_autonomic_nervous1.07821202
53MP0003698_abnormal_male_reproductive1.07247255
54MP0000631_abnormal_neuroendocrine_gland1.06701931
55MP0003137_abnormal_impulse_conducting1.06206996
56MP0006072_abnormal_retinal_apoptosis1.05934179
57MP0004924_abnormal_behavior1.05537031
58MP0005386_behavior/neurological_phenoty1.05537031
59MP0003631_nervous_system_phenotype1.05530628
60MP0010094_abnormal_chromosome_stability1.01422858
61MP0000778_abnormal_nervous_system0.95345652
62MP0000639_abnormal_adrenal_gland0.94136012
63MP0001929_abnormal_gametogenesis0.94125429
64MP0008058_abnormal_DNA_repair0.94042640
65MP0004484_altered_response_of0.93822993
66MP0001270_distended_abdomen0.92500321
67MP0003632_abnormal_nervous_system0.92184538
68MP0003656_abnormal_erythrocyte_physiolo0.90945984
69MP0004147_increased_porphyrin_level0.89695253
70MP0000230_abnormal_systemic_arterial0.86498093
71MP0008877_abnormal_DNA_methylation0.86352533
72MP0002269_muscular_atrophy0.85697802
73MP0010386_abnormal_urinary_bladder0.84511825
74MP0006292_abnormal_olfactory_placode0.84245079
75MP0001177_atelectasis0.83527726
76MP0002933_joint_inflammation0.82602834
77MP0002064_seizures0.81774966
78MP0001879_abnormal_lymphatic_vessel0.78637871
79MP0005367_renal/urinary_system_phenotyp0.77417671
80MP0000516_abnormal_urinary_system0.77417671
81MP0002557_abnormal_social/conspecific_i0.76182251
82MP0000534_abnormal_ureter_morphology0.74339143
83MP0001501_abnormal_sleep_pattern0.73295517
84MP0003329_amyloid_beta_deposits0.73055111
85MP0005623_abnormal_meninges_morphology0.72604027
86MP0003011_delayed_dark_adaptation0.70683071
87MP0004085_abnormal_heartbeat0.68485025
88MP0002733_abnormal_thermal_nociception0.67950662
89MP0009697_abnormal_copulation0.67766581
90MP0003890_abnormal_embryonic-extraembry0.67363201
91MP0003950_abnormal_plasma_membrane0.67204441
92MP0001986_abnormal_taste_sensitivity0.66954909
93MP0002168_other_aberrant_phenotype0.66766260
94MP0002066_abnormal_motor_capabilities/c0.66707461
95MP0004885_abnormal_endolymph0.65713819
96MP0000955_abnormal_spinal_cord0.63766890
97MP0000427_abnormal_hair_cycle0.62990694
98MP0000749_muscle_degeneration0.61642718
99MP0005195_abnormal_posterior_eye0.60799850
100MP0008569_lethality_at_weaning0.60694445

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.40561739
2Colon cancer (HP:0003003)4.31902467
3Rhabdomyosarcoma (HP:0002859)3.94918567
4Abnormal ciliary motility (HP:0012262)3.70174993
5Abnormal hair whorl (HP:0010721)3.59615047
6Gait imbalance (HP:0002141)3.56046522
7Medulloblastoma (HP:0002885)3.52382913
8Papillary thyroid carcinoma (HP:0002895)3.23496874
9Tubulointerstitial nephritis (HP:0001970)3.20676079
10Nephrogenic diabetes insipidus (HP:0009806)3.18974806
11Congenital primary aphakia (HP:0007707)3.09218482
12Pancreatic cysts (HP:0001737)3.01740855
13Epidermoid cyst (HP:0200040)2.97334219
14Abnormal respiratory motile cilium physiology (HP:0012261)2.95391063
15Medial flaring of the eyebrow (HP:0010747)2.92927483
16Neoplasm of striated muscle (HP:0009728)2.90202959
17Cortical dysplasia (HP:0002539)2.87175756
18Pancreatic fibrosis (HP:0100732)2.86230994
19Glioma (HP:0009733)2.84800380
20Abnormality of the astrocytes (HP:0100707)2.83366160
21Astrocytoma (HP:0009592)2.83366160
22Amyotrophic lateral sclerosis (HP:0007354)2.82168731
23Vaginal atresia (HP:0000148)2.82002295
24Genital tract atresia (HP:0001827)2.80572169
25Acanthocytosis (HP:0001927)2.77200955
26Nephronophthisis (HP:0000090)2.67714737
27Anteriorly placed anus (HP:0001545)2.67503654
28Aortic aneurysm (HP:0004942)2.57712923
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.57543404
30Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.51054601
31Ependymoma (HP:0002888)2.50489904
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.44398650
33Insulin-resistant diabetes mellitus (HP:0000831)2.43180211
34True hermaphroditism (HP:0010459)2.41452290
35Dyskinesia (HP:0100660)2.39705363
36Decreased central vision (HP:0007663)2.39549257
37Duodenal stenosis (HP:0100867)2.36793079
38Small intestinal stenosis (HP:0012848)2.36793079
39Abnormality of the renal medulla (HP:0100957)2.35035103
40Hemiparesis (HP:0001269)2.34876263
41Renal dysplasia (HP:0000110)2.31214516
42Natal tooth (HP:0000695)2.27141036
43Gaze-evoked nystagmus (HP:0000640)2.26061765
44Cerebellar dysplasia (HP:0007033)2.25698750
45Atonic seizures (HP:0010819)2.23715615
46Neoplasm of the oral cavity (HP:0100649)2.22904220
47Focal motor seizures (HP:0011153)2.21052013
48Abnormality of midbrain morphology (HP:0002418)2.20294218
49Molar tooth sign on MRI (HP:0002419)2.20294218
50Abnormality of the renal cortex (HP:0011035)2.18752799
51Long nose (HP:0003189)2.17011868
52Fibular hypoplasia (HP:0003038)2.12642225
53Abnormality of abdominal situs (HP:0011620)2.10992476
54Abdominal situs inversus (HP:0003363)2.10992476
55Anal stenosis (HP:0002025)2.10212089
56Cystic liver disease (HP:0006706)2.09132583
57Poor coordination (HP:0002370)2.07939376
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.07079005
59Hyperglycinemia (HP:0002154)2.04074313
60Focal seizures (HP:0007359)2.03985010
61Partial agenesis of the corpus callosum (HP:0001338)2.03276400
62Attenuation of retinal blood vessels (HP:0007843)2.00670434
63Retinal dysplasia (HP:0007973)1.99160219
64Stomach cancer (HP:0012126)1.97898838
65Abnormality of the duodenum (HP:0002246)1.96809301
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95638160
67Agnosia (HP:0010524)1.94794168
68Abnormal protein glycosylation (HP:0012346)1.94176128
69Abnormal glycosylation (HP:0012345)1.94176128
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94176128
71Abnormal protein N-linked glycosylation (HP:0012347)1.94176128
72Postaxial foot polydactyly (HP:0001830)1.93776176
73Type II lissencephaly (HP:0007260)1.92021662
74Narrow nasal bridge (HP:0000446)1.91702419
75Abnormal lung lobation (HP:0002101)1.89121907
76Pachygyria (HP:0001302)1.88402040
77Hypokinesia (HP:0002375)1.87921537
78Occipital encephalocele (HP:0002085)1.86840275
79Intestinal atresia (HP:0011100)1.86474690
80Thyroid carcinoma (HP:0002890)1.85024007
81Sclerocornea (HP:0000647)1.84213155
82Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82379843
83Neoplasm of the heart (HP:0100544)1.81909895
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.81546462
85Sloping forehead (HP:0000340)1.81467890
86Anencephaly (HP:0002323)1.80732663
87Astigmatism (HP:0000483)1.80247197
88Prominent nasal bridge (HP:0000426)1.78962480
89Broad foot (HP:0001769)1.77123584
90Heterotopia (HP:0002282)1.76674797
91Lissencephaly (HP:0001339)1.76502079
92Postaxial hand polydactyly (HP:0001162)1.74591066
93Dialeptic seizures (HP:0011146)1.74386012
94Chromsome breakage (HP:0040012)1.74082341
95Neoplasm of the colon (HP:0100273)1.73998267
96Oligodactyly (hands) (HP:0001180)1.69792600
97Intestinal polyposis (HP:0200008)1.69571198
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.69416470
99Abnormality of chromosome stability (HP:0003220)1.65153206
100Renal cortical cysts (HP:0000803)1.64733305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.20683475
2MAPK133.23420692
3CCNB13.13158862
4ERBB32.80199661
5BRSK22.63164939
6PLK42.46072999
7DMPK2.36484185
8NME12.29464062
9FRK2.15652409
10MARK12.09681909
11TNIK1.95941995
12MYLK1.89343151
13BCR1.85407591
14PHKG11.77415118
15PHKG21.77415118
16EIF2AK31.75266840
17CSNK1G31.71233052
18STK38L1.70924771
19CSNK1G21.68826744
20BRD41.63697680
21MST41.59878180
22CSNK1G11.58611628
23CSNK1A1L1.55578618
24ZAK1.48311209
25BMPR1B1.45314701
26WNK31.45064449
27ACVR1B1.44335574
28CAMKK21.43814993
29NUAK11.38252050
30MAP3K41.31405034
31PLK21.31380590
32TTK1.31141331
33DYRK21.27182591
34PBK1.25807761
35TRIM281.24104942
36MAPKAPK51.15577312
37MAP2K21.08984502
38WNK41.07747648
39MKNK11.07582367
40CDK31.07426462
41MAP2K71.05942009
42WEE11.00623675
43VRK10.97504839
44MAP2K10.97477354
45BRSK10.90451798
46WNK10.88324522
47MAP2K40.87941433
48INSRR0.85510768
49MAP3K130.82693666
50PKN10.78413360
51NEK90.78245390
52PINK10.77887572
53BCKDK0.76668309
54PRKCG0.71959090
55EIF2AK20.71607509
56STK30.67820353
57BMPR20.63679579
58NTRK30.63497314
59PLK10.61069533
60CDK120.59720648
61MKNK20.58666969
62TRPM70.58505083
63EPHA40.58442238
64PRKAA20.55646485
65PRKAA10.53484075
66PLK30.52144495
67STK380.51947515
68SGK10.51209480
69PNCK0.51043192
70EPHA30.49401241
71PRKACB0.47678446
72FLT30.47107775
73CLK10.46844715
74CHEK20.46802332
75RPS6KB10.44459315
76PRKCE0.43998914
77PAK30.42665383
78DAPK20.41443283
79IRAK10.40378990
80CAMK2B0.40301745
81CSNK1D0.39382039
82MAP2K60.39376911
83ROCK10.38381133
84CDK50.37661233
85CSNK1A10.36209464
86SRPK10.35337085
87MINK10.34141611
88PAK20.33865179
89DYRK1A0.33826568
90STK40.33471890
91ATM0.33160068
92CAMK2A0.32432757
93CDK140.31178305
94CSF1R0.30972998
95CDK180.30586811
96GSK3B0.30135507
97CDK150.30089063
98FGFR10.28514582
99CAMK2G0.28140678
100ADRBK10.27519766

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047423.50515728
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.30199410
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.93508089
4Fanconi anemia pathway_Homo sapiens_hsa034602.89547871
5Homologous recombination_Homo sapiens_hsa034402.75259244
6Nicotine addiction_Homo sapiens_hsa050332.61166845
7Mismatch repair_Homo sapiens_hsa034302.54038178
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37130075
9Regulation of autophagy_Homo sapiens_hsa041402.26263524
10Protein export_Homo sapiens_hsa030602.20626919
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18660416
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02189747
13Butanoate metabolism_Homo sapiens_hsa006501.98466647
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98261304
15RNA degradation_Homo sapiens_hsa030181.92517549
16GABAergic synapse_Homo sapiens_hsa047271.77943360
17Glutamatergic synapse_Homo sapiens_hsa047241.73002511
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70038741
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68700709
20Propanoate metabolism_Homo sapiens_hsa006401.65453834
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64288526
22Base excision repair_Homo sapiens_hsa034101.61922730
23Circadian entrainment_Homo sapiens_hsa047131.58431904
24Basal transcription factors_Homo sapiens_hsa030221.51978162
25RNA transport_Homo sapiens_hsa030131.48390288
26Calcium signaling pathway_Homo sapiens_hsa040201.39422875
27Dopaminergic synapse_Homo sapiens_hsa047281.31131030
28Type II diabetes mellitus_Homo sapiens_hsa049301.29709696
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23210355
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.19025676
31Fatty acid elongation_Homo sapiens_hsa000621.18993128
32Nucleotide excision repair_Homo sapiens_hsa034201.18118362
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.16436117
34Oocyte meiosis_Homo sapiens_hsa041141.15353190
35Morphine addiction_Homo sapiens_hsa050321.11704822
36Amphetamine addiction_Homo sapiens_hsa050311.11348477
37Long-term depression_Homo sapiens_hsa047301.09186109
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05398122
39Purine metabolism_Homo sapiens_hsa002301.04754262
40Serotonergic synapse_Homo sapiens_hsa047261.04596202
41Nitrogen metabolism_Homo sapiens_hsa009101.02216026
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00676660
43Inositol phosphate metabolism_Homo sapiens_hsa005620.96852298
44Oxytocin signaling pathway_Homo sapiens_hsa049210.95444485
45Non-homologous end-joining_Homo sapiens_hsa034500.94781758
46ABC transporters_Homo sapiens_hsa020100.93566603
47Salivary secretion_Homo sapiens_hsa049700.90182492
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89998158
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87560460
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83180249
51Folate biosynthesis_Homo sapiens_hsa007900.82642482
52Insulin secretion_Homo sapiens_hsa049110.78532809
53Selenocompound metabolism_Homo sapiens_hsa004500.77905499
54Fatty acid biosynthesis_Homo sapiens_hsa000610.75523197
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74854273
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72166530
57Linoleic acid metabolism_Homo sapiens_hsa005910.71104910
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70591344
59Pyruvate metabolism_Homo sapiens_hsa006200.70305593
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68619209
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68317880
62Steroid biosynthesis_Homo sapiens_hsa001000.65949477
63Olfactory transduction_Homo sapiens_hsa047400.65334941
64Long-term potentiation_Homo sapiens_hsa047200.64435972
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63238350
66RNA polymerase_Homo sapiens_hsa030200.60255744
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59670630
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59096965
69mTOR signaling pathway_Homo sapiens_hsa041500.56675403
70Cell cycle_Homo sapiens_hsa041100.56478065
71Biosynthesis of amino acids_Homo sapiens_hsa012300.56260903
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.55842864
73mRNA surveillance pathway_Homo sapiens_hsa030150.53315213
74Spliceosome_Homo sapiens_hsa030400.53165627
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52508416
76Huntingtons disease_Homo sapiens_hsa050160.51882853
77Collecting duct acid secretion_Homo sapiens_hsa049660.51796638
78Pyrimidine metabolism_Homo sapiens_hsa002400.51097873
79DNA replication_Homo sapiens_hsa030300.49136430
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.49113611
81Cholinergic synapse_Homo sapiens_hsa047250.48608470
82N-Glycan biosynthesis_Homo sapiens_hsa005100.48205622
83cAMP signaling pathway_Homo sapiens_hsa040240.47233091
84Synaptic vesicle cycle_Homo sapiens_hsa047210.47129068
85Peroxisome_Homo sapiens_hsa041460.44823673
86Circadian rhythm_Homo sapiens_hsa047100.44109674
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43259064
88Lysine degradation_Homo sapiens_hsa003100.42684557
89beta-Alanine metabolism_Homo sapiens_hsa004100.40759467
90Phototransduction_Homo sapiens_hsa047440.40686087
91p53 signaling pathway_Homo sapiens_hsa041150.40113209
92Colorectal cancer_Homo sapiens_hsa052100.37741824
93Fatty acid metabolism_Homo sapiens_hsa012120.35186517
94Renin secretion_Homo sapiens_hsa049240.34718636
95Cardiac muscle contraction_Homo sapiens_hsa042600.32843876
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31585607
97Mineral absorption_Homo sapiens_hsa049780.29771395
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28759721
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27685288
100Gap junction_Homo sapiens_hsa045400.25195047

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