INTS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.47812162
2COPI coating of Golgi vesicle (GO:0048205)5.10554281
3Golgi transport vesicle coating (GO:0048200)5.10554281
4folic acid-containing compound biosynthetic process (GO:0009396)4.80416692
5protein localization to kinetochore (GO:0034501)4.75104919
6viral transcription (GO:0019083)4.74903343
7translational termination (GO:0006415)4.64446161
8DNA strand elongation involved in DNA replication (GO:0006271)4.51982142
9maturation of SSU-rRNA (GO:0030490)4.42054145
10formation of translation preinitiation complex (GO:0001731)4.36535497
11ribosomal small subunit assembly (GO:0000028)4.32332351
12DNA strand elongation (GO:0022616)4.30877950
13DNA replication initiation (GO:0006270)4.29692837
14translational elongation (GO:0006414)4.25211737
15ribosomal large subunit biogenesis (GO:0042273)4.23031473
16translational initiation (GO:0006413)4.16468113
17protein localization to chromosome, centromeric region (GO:0071459)4.08815186
18ribosomal small subunit biogenesis (GO:0042274)4.05073230
19proline biosynthetic process (GO:0006561)4.01309438
20telomere maintenance via semi-conservative replication (GO:0032201)4.00109362
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99076552
22mitotic nuclear envelope disassembly (GO:0007077)3.83331419
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80355301
24IMP biosynthetic process (GO:0006188)3.74972237
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.71668259
26DNA replication-dependent nucleosome assembly (GO:0006335)3.70329106
27DNA replication-dependent nucleosome organization (GO:0034723)3.70329106
28protein targeting to ER (GO:0045047)3.69360892
29ribonucleoprotein complex biogenesis (GO:0022613)3.67324210
30DNA replication checkpoint (GO:0000076)3.67114464
31cellular protein complex disassembly (GO:0043624)3.67034677
32cotranslational protein targeting to membrane (GO:0006613)3.66662475
33pentose-phosphate shunt (GO:0006098)3.62018030
34mitotic sister chromatid segregation (GO:0000070)3.61353867
35viral life cycle (GO:0019058)3.56563132
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56541114
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56062019
38nucleobase biosynthetic process (GO:0046112)3.55960799
39nuclear envelope disassembly (GO:0051081)3.55618663
40membrane disassembly (GO:0030397)3.55618663
41protein localization to endosome (GO:0036010)3.54831861
42mitotic metaphase plate congression (GO:0007080)3.54153369
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51870993
44negative regulation of erythrocyte differentiation (GO:0045647)3.50624245
45protein complex disassembly (GO:0043241)3.45076067
46ribosome biogenesis (GO:0042254)3.43329007
47protein localization to endoplasmic reticulum (GO:0070972)3.42654110
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42265607
49peptidyl-arginine omega-N-methylation (GO:0035247)3.40001630
50DNA deamination (GO:0045006)3.39602233
51sister chromatid segregation (GO:0000819)3.37124386
52regulation of posttranscriptional gene silencing (GO:0060147)3.36211271
53regulation of gene silencing by miRNA (GO:0060964)3.36211271
54regulation of gene silencing by RNA (GO:0060966)3.36211271
55telomere maintenance via recombination (GO:0000722)3.35273821
56regulation of translational fidelity (GO:0006450)3.33649306
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32747414
58heterochromatin organization (GO:0070828)3.31541603
59protein retention in ER lumen (GO:0006621)3.29353273
60DNA duplex unwinding (GO:0032508)3.29153097
61telomere maintenance via telomere lengthening (GO:0010833)3.28563426
62nuclear pore organization (GO:0006999)3.28296203
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.28271119
64pinocytosis (GO:0006907)3.26884230
65regulation of chromatin binding (GO:0035561)3.25332517
66DNA geometric change (GO:0032392)3.24890926
67mitotic recombination (GO:0006312)3.24473801
68IMP metabolic process (GO:0046040)3.24138923
69folic acid metabolic process (GO:0046655)3.22767163
70macromolecular complex disassembly (GO:0032984)3.22329996
71rRNA processing (GO:0006364)3.19170756
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18442601
73mitotic nuclear envelope reassembly (GO:0007084)3.16399210
74nuclear envelope reassembly (GO:0031468)3.16399210
75negative regulation of RNA splicing (GO:0033119)3.15882077
76rRNA metabolic process (GO:0016072)3.14643860
77NADPH regeneration (GO:0006740)3.14366772
78mitotic G1 DNA damage checkpoint (GO:0031571)3.13012622
79nuclear-transcribed mRNA catabolic process (GO:0000956)3.10881954
80mitotic chromosome condensation (GO:0007076)3.10356073
81glucose catabolic process (GO:0006007)3.08189971
82epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07827830
83NIK/NF-kappaB signaling (GO:0038061)3.07745895
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.07564373
85ncRNA 3-end processing (GO:0043628)3.06617081
86protein maturation by protein folding (GO:0022417)3.06345054
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06135145
883-UTR-mediated mRNA stabilization (GO:0070935)3.04661171
89apoptotic process involved in morphogenesis (GO:0060561)3.02821453
90nuclear pore complex assembly (GO:0051292)3.02128247
91purine nucleobase biosynthetic process (GO:0009113)2.99863615
92ribosome assembly (GO:0042255)2.99474730
93positive regulation of chromosome segregation (GO:0051984)2.98829010
94RNA catabolic process (GO:0006401)2.95644889
95metaphase plate congression (GO:0051310)2.95314301
96mRNA catabolic process (GO:0006402)2.95116502
97negative regulation of viral release from host cell (GO:1902187)2.94418333
98negative regulation of cell size (GO:0045792)2.94229506
99pseudouridine synthesis (GO:0001522)2.93897195
100translation (GO:0006412)2.93887634
101attachment of spindle microtubules to kinetochore (GO:0008608)2.92558215
102regulation of spindle organization (GO:0090224)2.90111968
103nuclear envelope organization (GO:0006998)2.87525341
104GDP-mannose metabolic process (GO:0019673)2.86884880
105negative regulation of mRNA processing (GO:0050686)2.86677713
106pre-miRNA processing (GO:0031054)2.86603208
107modulation by symbiont of host cellular process (GO:0044068)2.86412209
108histone arginine methylation (GO:0034969)2.86252266
109tetrahydrofolate metabolic process (GO:0046653)2.83728082
110spliceosomal snRNP assembly (GO:0000387)2.83073828
111peptidyl-arginine methylation (GO:0018216)2.81744264
112peptidyl-arginine N-methylation (GO:0035246)2.81744264
113regulation of protein heterodimerization activity (GO:0043497)2.79975127
114protein localization to chromosome (GO:0034502)2.79544341
115pteridine-containing compound biosynthetic process (GO:0042559)2.77737113
116positive regulation of Cdc42 GTPase activity (GO:0043089)2.76160526
117RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74617069
118mRNA splicing, via spliceosome (GO:0000398)2.74617069
119RNA splicing, via transesterification reactions (GO:0000375)2.74240266
120modulation by virus of host process (GO:0019054)2.74035313
121mitotic G1/S transition checkpoint (GO:0044819)2.72537184
122negative regulation of mRNA metabolic process (GO:1903312)2.69925351
123protein complex localization (GO:0031503)2.69152859
124regulation of translational termination (GO:0006449)2.68930360
125chromatin assembly or disassembly (GO:0006333)2.68036798
126mitochondrial fusion (GO:0008053)2.67546130
127cellular response to interleukin-4 (GO:0071353)2.65996243
128establishment of chromosome localization (GO:0051303)2.65810555
129positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.65641818
130establishment of integrated proviral latency (GO:0075713)2.64860393
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64766370
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.64766370
133regulation of mitotic spindle organization (GO:0060236)2.64311727
134cellular protein complex localization (GO:0034629)2.61973833
135UV protection (GO:0009650)2.61802455
136activation of Rac GTPase activity (GO:0032863)2.60816520
137barbed-end actin filament capping (GO:0051016)2.59655290
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59450546
139positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58867219
140chaperone mediated protein folding requiring cofactor (GO:0051085)2.55594525
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.54047433
142positive regulation of nuclease activity (GO:0032075)2.49816220
143rRNA transcription (GO:0009303)2.49680012
144intracellular estrogen receptor signaling pathway (GO:0030520)2.48916789
145activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48836065
146cellular response to virus (GO:0098586)2.47560401
147pentose metabolic process (GO:0019321)2.47439868
148maternal placenta development (GO:0001893)2.46639130
149adherens junction assembly (GO:0034333)2.46118152
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41363345
151glucose 6-phosphate metabolic process (GO:0051156)2.40778167
152mannose metabolic process (GO:0006013)2.40024498
153focal adhesion assembly (GO:0048041)2.39975518
154cell-substrate adherens junction assembly (GO:0007045)2.39975518
155regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39810641
156regulation of early endosome to late endosome transport (GO:2000641)2.39747251
157amyloid precursor protein catabolic process (GO:0042987)2.39692420
158stress fiber assembly (GO:0043149)2.38879165
159response to peptidoglycan (GO:0032494)2.37629224
160mitochondrial DNA metabolic process (GO:0032042)2.35051929
161nucleobase-containing small molecule interconversion (GO:0015949)2.34721852
162embryonic process involved in female pregnancy (GO:0060136)2.33810077
163regulation of NFAT protein import into nucleus (GO:0051532)2.33212533
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31123569
165response to interleukin-4 (GO:0070670)2.30226152
166regulation of nuclease activity (GO:0032069)2.29496151
167endoplasmic reticulum unfolded protein response (GO:0030968)2.29183418
168activation of MAPKKK activity (GO:0000185)2.27915995
169regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.25846745
170proline metabolic process (GO:0006560)2.25236864
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.23272882
172protein insertion into membrane (GO:0051205)2.22269891
173establishment of viral latency (GO:0019043)2.22252311
174regulation of superoxide anion generation (GO:0032928)2.22176254
175regulation of defense response to virus by virus (GO:0050690)2.22070173
176ER-nucleus signaling pathway (GO:0006984)2.21759171
177positive regulation of keratinocyte differentiation (GO:0045618)2.20617495
178modulation by virus of host morphology or physiology (GO:0019048)2.19713260
179negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.17926931
180virion assembly (GO:0019068)2.16042076
181response to laminar fluid shear stress (GO:0034616)2.14904527
182pyrimidine nucleoside salvage (GO:0043097)2.13889920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51059412
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05135778
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.03994009
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84184938
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00694173
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85080717
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73437234
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55035922
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53385423
10MYC_22102868_ChIP-Seq_BL_Human2.48251074
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.33260987
12* XRN2_22483619_ChIP-Seq_HELA_Human2.26868570
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.18943515
14LXR_22292898_ChIP-Seq_THP-1_Human2.16911815
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16511089
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.12554744
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06903573
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06104453
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02138799
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00632531
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97161260
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.88802410
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77302359
24RACK7_27058665_Chip-Seq_MCF-7_Human1.76961820
25AR_21909140_ChIP-Seq_LNCAP_Human1.75638791
26DCP1A_22483619_ChIP-Seq_HELA_Human1.74350474
27VDR_21846776_ChIP-Seq_THP-1_Human1.72870330
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72313081
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71622971
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.69855579
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68758970
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66833216
33CIITA_25753668_ChIP-Seq_RAJI_Human1.64225204
34GABP_19822575_ChIP-Seq_HepG2_Human1.63678337
35* VDR_23849224_ChIP-Seq_CD4+_Human1.63605463
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62670650
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61806073
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60465996
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59376921
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59152353
41* KDM5A_27292631_Chip-Seq_BREAST_Human1.59126863
42* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59076217
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58625708
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58311001
45* FOXP3_21729870_ChIP-Seq_TREG_Human1.57120900
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54045364
47TTF2_22483619_ChIP-Seq_HELA_Human1.53588508
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51444083
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50577274
50KDM2B_26808549_Chip-Seq_DND41_Human1.50050140
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48294696
52VDR_24763502_ChIP-Seq_THP-1_Human1.46428980
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46277471
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.44662076
55* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44159084
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43963189
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42833348
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41574954
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41363099
60ZNF263_19887448_ChIP-Seq_K562_Human1.39085910
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38694192
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38216153
63* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34520838
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32380334
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31753570
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28942607
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28420173
68P68_20966046_ChIP-Seq_HELA_Human1.28170703
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25053981
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.24727461
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24656673
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23309295
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23086203
74* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22908354
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22737707
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20955125
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20648395
78* NCOR1_26117541_ChIP-Seq_K562_Human1.20181981
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.19473634
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.19357508
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17571822
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.16229293
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15723856
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14501839
85TFEB_21752829_ChIP-Seq_HELA_Human1.13841788
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.12714114
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12664352
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11752008
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11156622
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10890850
91* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09982809
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09713036
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09074922
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08494388
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07457173
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07154483
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06607615
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06574705
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05945673
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05658147
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05401047
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04899047
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04714604
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.04710811
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04055670
106CLOCK_20551151_ChIP-Seq_293T_Human1.03923046
107BCOR_27268052_Chip-Seq_Bcells_Human1.03919975
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03400575
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03218707
110UTX_26944678_Chip-Seq_JUKART_Human1.02931955
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02725105
112BP1_19119308_ChIP-ChIP_Hs578T_Human1.02629900
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02597260
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01342366
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01256666
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01173630
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01161094
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.01156487
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00674196
120ATF3_27146783_Chip-Seq_COLON_Human1.00515073
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00024574
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98806275
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97509250
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97509250
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97509250
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97351647
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97084739
128TCF7_22412390_ChIP-Seq_EML_Mouse0.96897343
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96851260
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95420778
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93311382
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93261951
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.93133977
134MAF_26560356_Chip-Seq_TH1_Human0.92334158
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.92000311
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91403108
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91289348
138CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90701801
139* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90163660
140CHD1_26751641_Chip-Seq_LNCaP_Human0.89062427
141MAF_26560356_Chip-Seq_TH2_Human0.87535615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.06517996
2MP0003111_abnormal_nucleus_morphology3.90436908
3MP0004957_abnormal_blastocyst_morpholog3.82265681
4MP0010352_gastrointestinal_tract_polyps3.68719562
5MP0005451_abnormal_body_composition3.62568230
6MP0010094_abnormal_chromosome_stability3.34237645
7MP0003705_abnormal_hypodermis_morpholog3.30507958
8MP0003077_abnormal_cell_cycle3.25433083
9MP0008057_abnormal_DNA_replication2.98733161
10MP0005058_abnormal_lysosome_morphology2.83581153
11MP0010030_abnormal_orbit_morphology2.83216090
12MP0008260_abnormal_autophagy2.43586075
13MP0001730_embryonic_growth_arrest2.37553856
14MP0008932_abnormal_embryonic_tissue2.29377754
15MP0005076_abnormal_cell_differentiation2.29305848
16MP0000350_abnormal_cell_proliferation2.24196903
17MP0003303_peritoneal_inflammation2.21121477
18MP0008007_abnormal_cellular_replicative2.13263921
19MP0003436_decreased_susceptibility_to2.09894234
20MP0004858_abnormal_nervous_system1.99301549
21MP0008058_abnormal_DNA_repair1.93260056
22MP0002396_abnormal_hematopoietic_system1.90565753
23MP0001697_abnormal_embryo_size1.82568673
24MP0000490_abnormal_crypts_of1.81680820
25MP0005380_embryogenesis_phenotype1.79883529
26MP0001672_abnormal_embryogenesis/_devel1.79883529
27MP0003123_paternal_imprinting1.78039743
28MP0002796_impaired_skin_barrier1.76099767
29MP0004197_abnormal_fetal_growth/weight/1.73826158
30MP0003984_embryonic_growth_retardation1.70731467
31MP0010307_abnormal_tumor_latency1.69461024
32MP0002080_prenatal_lethality1.69072238
33MP0002088_abnormal_embryonic_growth/wei1.67681779
34MP0002085_abnormal_embryonic_tissue1.66757913
35MP0003191_abnormal_cellular_cholesterol1.63747435
36MP0004947_skin_inflammation1.63107231
37MP0002086_abnormal_extraembryonic_tissu1.58913314
38MP0002084_abnormal_developmental_patter1.56646388
39MP0005023_abnormal_wound_healing1.47607265
40MP0009333_abnormal_splenocyte_physiolog1.40920341
41MP0002019_abnormal_tumor_incidence1.40576145
42MP0006054_spinal_hemorrhage1.40057597
43MP0002877_abnormal_melanocyte_morpholog1.37893351
44MP0003091_abnormal_cell_migration1.35504986
45MP0004808_abnormal_hematopoietic_stem1.32990802
46MP0003567_abnormal_fetal_cardiomyocyte1.32760170
47MP0005623_abnormal_meninges_morphology1.32399141
48MP0001835_abnormal_antigen_presentation1.30466098
49MP0000313_abnormal_cell_death1.27664000
50MP0000858_altered_metastatic_potential1.24626140
51MP0009278_abnormal_bone_marrow1.24025906
52MP0001293_anophthalmia1.23431724
53MP0003566_abnormal_cell_adhesion1.22792556
54MP0002653_abnormal_ependyma_morphology1.22369912
55MP0000678_abnormal_parathyroid_gland1.21695384
56MP0005000_abnormal_immune_tolerance1.20546330
57MP0000703_abnormal_thymus_morphology1.20487009
58MP0003786_premature_aging1.18237793
59MP0005025_abnormal_response_to1.17622348
60MP0001545_abnormal_hematopoietic_system1.17429403
61MP0005397_hematopoietic_system_phenotyp1.17429403
62MP0001849_ear_inflammation1.17009855
63MP0000537_abnormal_urethra_morphology1.16742804
64MP0003763_abnormal_thymus_physiology1.14031031
65MP0003172_abnormal_lysosome_physiology1.13377265
66MP0009053_abnormal_anal_canal1.11956640
67MP0003119_abnormal_digestive_system1.09852348
68MP0004510_myositis1.09810894
69MP0002060_abnormal_skin_morphology1.09250926
70MP0000428_abnormal_craniofacial_morphol1.08847378
71MP0000358_abnormal_cell_content/1.08126392
72MP0003890_abnormal_embryonic-extraembry1.06714285
73MP0002419_abnormal_innate_immunity1.05168248
74MP0001790_abnormal_immune_system1.03875725
75MP0005387_immune_system_phenotype1.03875725
76MP0002722_abnormal_immune_system1.02151567
77MP0001661_extended_life_span1.02121310
78MP0002111_abnormal_tail_morphology1.01272369
79MP0002452_abnormal_antigen_presenting1.00689981
80MP0001873_stomach_inflammation1.00522407
81MP0001216_abnormal_epidermal_layer0.99804670
82MP0002398_abnormal_bone_marrow0.99650479
83MP0000733_abnormal_muscle_development0.99052035
84MP0003075_altered_response_to0.98146055
85MP0000477_abnormal_intestine_morphology0.97344782
86MP0001727_abnormal_embryo_implantation0.96893406
87MP0005464_abnormal_platelet_physiology0.96521968
88MP0001819_abnormal_immune_cell0.95720316
89MP0002420_abnormal_adaptive_immunity0.95685354
90MP0000750_abnormal_muscle_regeneration0.93849285
91MP0005310_abnormal_salivary_gland0.93646404
92MP0001346_abnormal_lacrimal_gland0.92912987
93MP0009931_abnormal_skin_appearance0.92576996
94MP0002089_abnormal_postnatal_growth/wei0.92074488
95MP0002723_abnormal_immune_serum0.91951600
96MP0000689_abnormal_spleen_morphology0.91585975
97MP0009672_abnormal_birth_weight0.91389112
98MP0002148_abnormal_hypersensitivity_rea0.89578650
99MP0000716_abnormal_immune_system0.89260532
100MP0004185_abnormal_adipocyte_glucose0.88840434
101MP0000003_abnormal_adipose_tissue0.88239905
102MP0001853_heart_inflammation0.88174919
103MP0001800_abnormal_humoral_immune0.88103585
104MP0002166_altered_tumor_susceptibility0.87201410
105MP0005621_abnormal_cell_physiology0.87063491
106MP0005501_abnormal_skin_physiology0.86979764
107MP0005384_cellular_phenotype0.86496105
108MP0001915_intracranial_hemorrhage0.85659123
109MP0002092_abnormal_eye_morphology0.85465203
110MP0003300_gastrointestinal_ulcer0.85328140
111MP0002254_reproductive_system_inflammat0.84990006
112MP0005083_abnormal_biliary_tract0.83744582
113MP0003221_abnormal_cardiomyocyte_apopto0.83215828
114MP0002249_abnormal_larynx_morphology0.82099902
115MP0003329_amyloid_beta_deposits0.81187976
116MP0009785_altered_susceptibility_to0.80814695
117MP0009840_abnormal_foam_cell0.79279143
118MP0004264_abnormal_extraembryonic_tissu0.78626951
119MP0002429_abnormal_blood_cell0.76362570
120MP0003115_abnormal_respiratory_system0.76202958
121MP0008438_abnormal_cutaneous_collagen0.74008699
122MP0003806_abnormal_nucleotide_metabolis0.74001803
123MP0001348_abnormal_lacrimal_gland0.73336690
124MP0004133_heterotaxia0.73007426
125MP0008770_decreased_survivor_rate0.72989946
126MP0002925_abnormal_cardiovascular_devel0.72862478
127MP0003315_abnormal_perineum_morphology0.71218132
128MP0009703_decreased_birth_body0.70876393
129MP0003937_abnormal_limbs/digits/tail_de0.70770097
130MP0003942_abnormal_urinary_system0.70378677
131MP0002932_abnormal_joint_morphology0.70265668
132MP0004233_abnormal_muscle_weight0.68533188
133MP0000685_abnormal_immune_system0.67598298
134MP0010234_abnormal_vibrissa_follicle0.67177418
135MP0003121_genomic_imprinting0.66999088
136MP0005257_abnormal_intraocular_pressure0.66331368
137MP0000049_abnormal_middle_ear0.64186657
138MP0000377_abnormal_hair_follicle0.63612146
139MP0003448_altered_tumor_morphology0.63404575
140MP0002970_abnormal_white_adipose0.62522549
141MP0001286_abnormal_eye_development0.62110892
142MP0003935_abnormal_craniofacial_develop0.61941083
143MP0002405_respiratory_system_inflammati0.61122136
144MP0001243_abnormal_dermal_layer0.60948915
145MP0005220_abnormal_exocrine_pancreas0.60613985
146MP0003453_abnormal_keratinocyte_physiol0.60321373

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.14835650
2Abnormal number of erythroid precursors (HP:0012131)3.93111261
3Ependymoma (HP:0002888)3.66152342
4Selective tooth agenesis (HP:0001592)3.59229103
5Birth length less than 3rd percentile (HP:0003561)3.50169895
6Basal cell carcinoma (HP:0002671)3.35556880
7Microvesicular hepatic steatosis (HP:0001414)3.29286127
8Reticulocytopenia (HP:0001896)3.25970302
9Breast hypoplasia (HP:0003187)3.19820412
10Ragged-red muscle fibers (HP:0003200)3.07749243
11Trismus (HP:0000211)3.06727063
12Pallor (HP:0000980)2.93582162
13Colon cancer (HP:0003003)2.92214997
14Vertebral compression fractures (HP:0002953)2.87804805
15Achilles tendon contracture (HP:0001771)2.86814435
16Macrocytic anemia (HP:0001972)2.85752508
17Cholecystitis (HP:0001082)2.75913967
18Abnormal gallbladder physiology (HP:0012438)2.75913967
19Absent thumb (HP:0009777)2.69828412
20Cellulitis (HP:0100658)2.67626550
21Patellar aplasia (HP:0006443)2.62594423
22Increased connective tissue (HP:0009025)2.60354073
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.59568957
24Medulloblastoma (HP:0002885)2.56426351
25Oral leukoplakia (HP:0002745)2.56036533
26Neoplasm of the pancreas (HP:0002894)2.55922596
27Hypertensive crisis (HP:0100735)2.55638794
28Atresia of the external auditory canal (HP:0000413)2.53527007
29Multiple enchondromatosis (HP:0005701)2.51265896
30Rough bone trabeculation (HP:0100670)2.50970593
31Abnormal number of incisors (HP:0011064)2.49947724
32Abnormality of the distal phalanges of the toes (HP:0010182)2.47429812
33Aplasia/Hypoplasia of the patella (HP:0006498)2.47358126
34Missing ribs (HP:0000921)2.46762742
35Adenoma sebaceum (HP:0009720)2.46351327
36Angiofibromas (HP:0010615)2.46351327
37Progressive muscle weakness (HP:0003323)2.46003715
38Abnormality of the Achilles tendon (HP:0005109)2.45721182
39Squamous cell carcinoma (HP:0002860)2.43286912
40Increased nuchal translucency (HP:0010880)2.41432875
41Genu recurvatum (HP:0002816)2.40515645
42Distal lower limb amyotrophy (HP:0008944)2.39361872
43Hyperacusis (HP:0010780)2.38292084
44Rhabdomyosarcoma (HP:0002859)2.35581130
45Astrocytoma (HP:0009592)2.35541645
46Abnormality of the astrocytes (HP:0100707)2.35541645
47Protrusio acetabuli (HP:0003179)2.35034127
48Abnormality of the anterior horn cell (HP:0006802)2.34690865
49Degeneration of anterior horn cells (HP:0002398)2.34690865
50Long palpebral fissure (HP:0000637)2.32959181
51Distal lower limb muscle weakness (HP:0009053)2.31059460
52Deviation of the thumb (HP:0009603)2.30879711
5311 pairs of ribs (HP:0000878)2.29956048
54Distal upper limb amyotrophy (HP:0007149)2.29658171
55Upper limb amyotrophy (HP:0009129)2.29658171
56Renal duplication (HP:0000075)2.28283298
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26664525
58Abnormality of glycolipid metabolism (HP:0010969)2.26558049
59Abnormality of liposaccharide metabolism (HP:0010968)2.26558049
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.26558049
61Proximal placement of thumb (HP:0009623)2.25364869
62Broad distal phalanx of finger (HP:0009836)2.23609551
63Increased density of long bones (HP:0006392)2.22814176
64Carpal bone hypoplasia (HP:0001498)2.21212305
65Slender long bone (HP:0003100)2.20867607
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20141767
67Short 4th metacarpal (HP:0010044)2.20141767
68Loss of speech (HP:0002371)2.18392256
69Ulnar bowing (HP:0003031)2.18074647
70Broad face (HP:0000283)2.17277041
71Eczematoid dermatitis (HP:0000976)2.16393786
72Overlapping toe (HP:0001845)2.13158576
73Neoplasm of striated muscle (HP:0009728)2.11532969
74Premature rupture of membranes (HP:0001788)2.09447331
75Preauricular skin tag (HP:0000384)2.06233549
76Cerebral hypomyelination (HP:0006808)2.05461343
77Interstitial pulmonary disease (HP:0006530)2.04361448
78Increased cerebral lipofuscin (HP:0011813)2.03808127
79Reticulocytosis (HP:0001923)2.02549081
80Skin tags (HP:0010609)2.01276995
81Abnormality of reticulocytes (HP:0004312)2.00401712
82Sparse lateral eyebrow (HP:0005338)2.00095905
83Agnosia (HP:0010524)1.98661186
84Generalized amyotrophy (HP:0003700)1.97532350
85Progressive external ophthalmoplegia (HP:0000590)1.96105992
86Biliary tract neoplasm (HP:0100574)1.95812098
87Stenosis of the external auditory canal (HP:0000402)1.93539554
88Hand muscle atrophy (HP:0009130)1.92251817
89Dysostosis multiplex (HP:0000943)1.91248672
90Abnormality of the thoracic spine (HP:0100711)1.89162866
91Recurrent abscess formation (HP:0002722)1.89034038
92Microretrognathia (HP:0000308)1.88793624
93Increased IgE level (HP:0003212)1.88317993
94Polygenic inheritance (HP:0010982)1.88255312
95Bicuspid aortic valve (HP:0001647)1.87699160
96Hepatosplenomegaly (HP:0001433)1.87300644
97Ankle contracture (HP:0006466)1.86010165
98Colitis (HP:0002583)1.85885578
99Hyperparathyroidism (HP:0000843)1.84942916
100Glioma (HP:0009733)1.84714230
101Short nail (HP:0001799)1.84610125
102Flat acetabular roof (HP:0003180)1.84407015
103Glossoptosis (HP:0000162)1.83624494
104Hemorrhage of the eye (HP:0011885)1.83007657
105High pitched voice (HP:0001620)1.82954531
106Absent radius (HP:0003974)1.82069400
107Premature graying of hair (HP:0002216)1.80947715
108Gastrointestinal inflammation (HP:0004386)1.80305970
109Recurrent viral infections (HP:0004429)1.79597836
110Flattened epiphyses (HP:0003071)1.79150296
111Myopathic facies (HP:0002058)1.78836617
112Abnormality of the calcaneus (HP:0008364)1.78311643
113Thin bony cortex (HP:0002753)1.77831122
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.76929718
115Ovarian neoplasm (HP:0100615)1.76886075
116Abnormality of macrophages (HP:0004311)1.76784041
117Tracheoesophageal fistula (HP:0002575)1.76361445
118Diaphragmatic weakness (HP:0009113)1.76203230
119Thoracic kyphosis (HP:0002942)1.75331435
120Aplasia/hypoplasia of the humerus (HP:0006507)1.74845740
121Upper motor neuron abnormality (HP:0002127)1.72835730
122Back pain (HP:0003418)1.72443959
123Increased serum ferritin (HP:0003281)1.72067624
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.71517474
125Abnormality of the labia minora (HP:0012880)1.71180077
126Hypokinesia (HP:0002375)1.70802212
127Entropion (HP:0000621)1.70413773
128Stridor (HP:0010307)1.70278797
129Cafe-au-lait spot (HP:0000957)1.69844763
130Nonimmune hydrops fetalis (HP:0001790)1.69504025
131Micronodular cirrhosis (HP:0001413)1.69242705
132Facial hemangioma (HP:0000329)1.68055618
133Myelodysplasia (HP:0002863)1.67903283
134Prominent nose (HP:0000448)1.66667018
135Rib fusion (HP:0000902)1.66610626
136Fragile skin (HP:0001030)1.66578486
137Absent forearm bone (HP:0003953)1.66521025
138Aplasia involving forearm bones (HP:0009822)1.66521025
139Fatigue (HP:0012378)1.65960818
140Elbow flexion contracture (HP:0002987)1.65394849
141Bulbar palsy (HP:0001283)1.64246310
142Gastrointestinal dysmotility (HP:0002579)1.63417686
143Short palpebral fissure (HP:0012745)1.63058521
144Patellar dislocation (HP:0002999)1.62824194
145Osteolytic defects of the hand bones (HP:0009699)1.62710886
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.62710886
147Neoplasm of the oral cavity (HP:0100649)1.62574081
148Thrombocytosis (HP:0001894)1.62537463
149Recurrent bacterial skin infections (HP:0005406)1.62242260
150Overriding aorta (HP:0002623)1.62023020
151Abnormal trabecular bone morphology (HP:0100671)1.61849569
152Difficulty climbing stairs (HP:0003551)1.61564211
153Neoplasm of the colon (HP:0100273)1.60937930
154Aplastic anemia (HP:0001915)1.60398736
155Shallow orbits (HP:0000586)1.60095090
156Insomnia (HP:0100785)1.59627067
157Elevated alkaline phosphatase (HP:0003155)1.59318777
158Poikiloderma (HP:0001029)1.58780080
159Long eyelashes (HP:0000527)1.58426141
160Hypochromic anemia (HP:0001931)1.58239149
161Cholelithiasis (HP:0001081)1.58146281
162Dilatation of the ascending aorta (HP:0005111)1.58055536
163Premature ovarian failure (HP:0008209)1.57230176
164Progressive hearing impairment (HP:0001730)1.57189642
165Gastrointestinal stroma tumor (HP:0100723)1.56767903
166Intestinal polyp (HP:0005266)1.56671756
167Bowel diverticulosis (HP:0005222)1.56558346
168Petechiae (HP:0000967)1.56205068
169Abnormality of the umbilical cord (HP:0010881)1.55693686
170Hypoplasia of the radius (HP:0002984)1.55358070
171Impulsivity (HP:0100710)1.55285925
172Mesangial abnormality (HP:0001966)1.54968580
173Axonal loss (HP:0003447)1.54843434
174Abdominal situs inversus (HP:0003363)1.54773949
175Abnormality of abdominal situs (HP:0011620)1.54773949
176Blue sclerae (HP:0000592)1.54525540
177Mediastinal lymphadenopathy (HP:0100721)1.54232182
178Asymmetry of the thorax (HP:0001555)1.52981755
179Testicular atrophy (HP:0000029)1.52583481
180Hypercortisolism (HP:0001578)1.52349993
181Abnormal ossification of hand bones (HP:0005921)1.51662816
182Viral hepatitis (HP:0006562)1.51220863
183Spastic diplegia (HP:0001264)1.51117725
184Abnormality of alkaline phosphatase activity (HP:0004379)1.50992428
185Septate vagina (HP:0001153)1.50764365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.50380480
2SMG14.34296991
3EEF2K3.60630913
4EIF2AK13.34814428
5CDC73.32197683
6PRPF4B3.27599570
7IRAK33.12688167
8MAP3K102.63801394
9WEE12.59675433
10TRIB32.53695005
11RPS6KB22.53268982
12NEK22.46583364
13NME22.46563722
14CDK122.27610798
15VRK22.07762068
16PKN22.06692573
17TAOK22.02929740
18TESK21.95001466
19EIF2AK31.89826661
20ERN11.74828001
21CDK71.72605827
22STK101.70305228
23TTK1.63951484
24TLK11.62153755
25ARAF1.60890720
26RPS6KA41.60460020
27DYRK31.57036183
28MAP3K81.52154080
29EPHA21.50565274
30CDK41.48717940
31MAP4K11.46000356
32NEK11.45888593
33PASK1.45055610
34PLK11.42313743
35MAP3K31.33895815
36SCYL21.32197041
37LRRK21.30800046
38PAK41.28111355
39LATS21.26745902
40AURKB1.24282951
41ALK1.20560117
42TBK11.19527593
43TSSK61.16256919
44BRSK11.14263005
45ATR1.14094482
46ILK1.13857073
47KDR1.12220518
48FGFR41.09908335
49AURKA1.07042156
50BRSK21.05191334
51GRK61.01171863
52SRPK11.01165890
53CHEK20.99221799
54MAP3K110.98979079
55MAPKAPK30.97884198
56PIM20.97632531
57RIPK10.96589795
58EPHB10.96392380
59CHEK10.95600230
60MKNK10.94063284
61PAK10.92932437
62TAF10.92388321
63IRAK40.92206867
64MTOR0.90466059
65FLT30.85955525
66ICK0.85206944
67MAP3K10.84367360
68PIM10.84334377
69ACVR1B0.84028831
70BMX0.82159045
71TTN0.80352814
72PAK20.79619754
73BRAF0.79553600
74CDK60.78504706
75LMTK20.78248468
76MAP3K140.78057861
77PRKD20.76802645
78VRK10.75983388
79IRAK20.75870584
80CDK20.74700570
81MELK0.73589506
82KSR20.73180242
83RIPK40.72606059
84PLK40.71559980
85TGFBR10.70503274
86MKNK20.68487170
87PTK60.67990922
88STK40.67331888
89MST1R0.67197060
90PRKCI0.66322690
91HIPK20.64529785
92MAPK110.63936961
93RAF10.62627882
94ZAP700.62019410
95RPS6KA20.61508500
96MAP3K130.61276099
97DAPK10.61053489
98MAP2K30.60767960
99SIK10.59925407
100DAPK30.58066936
101ATM0.57963281
102PLK30.56630459
103STK30.55689819
104PRKD30.55550086
105PDGFRA0.53642965
106TESK10.52365475
107PDPK10.49718401
108CSNK2A20.49190551
109AKT20.48231561
110CDK10.47568598
111LATS10.47078512
112FGFR10.46788232
113RPS6KC10.46410910
114RPS6KL10.46410910
115RPS6KA10.45908440
116MOS0.45490580
117CDK80.44366987
118SIK30.41721836
119RPS6KA60.38899992
120MARK20.37946878
121BCKDK0.37051508
122BRD40.36769553
123PBK0.36556794
124PTK20.36384587
125DYRK1B0.36099821
126CDC42BPA0.35813796
127IKBKB0.35674751
128CSNK2A10.35586211
129MAPKAPK20.35170068
130BTK0.34944025
131MUSK0.34834758
132CSNK1E0.34309294
133MAP2K20.33155995
134TAOK10.30465127
135TYK20.27857901
136JAK30.27208706
137CLK10.27073927
138CDK90.26786103

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72205417
2Ribosome_Homo sapiens_hsa030103.95617096
3Mismatch repair_Homo sapiens_hsa034303.91814663
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35070742
5One carbon pool by folate_Homo sapiens_hsa006703.07247528
6Spliceosome_Homo sapiens_hsa030403.02589811
7RNA transport_Homo sapiens_hsa030132.90776491
8Base excision repair_Homo sapiens_hsa034102.67882557
9Cell cycle_Homo sapiens_hsa041102.63867782
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62144162
11Nucleotide excision repair_Homo sapiens_hsa034202.44087986
12RNA polymerase_Homo sapiens_hsa030202.42355566
13Other glycan degradation_Homo sapiens_hsa005112.35410587
14Proteasome_Homo sapiens_hsa030502.33763762
15Homologous recombination_Homo sapiens_hsa034402.29403210
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87763596
17Pyrimidine metabolism_Homo sapiens_hsa002401.86370274
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63392840
19p53 signaling pathway_Homo sapiens_hsa041151.57794088
20Fanconi anemia pathway_Homo sapiens_hsa034601.55831236
21mRNA surveillance pathway_Homo sapiens_hsa030151.55693435
22Biosynthesis of amino acids_Homo sapiens_hsa012301.52481953
23RNA degradation_Homo sapiens_hsa030181.47249402
24Non-homologous end-joining_Homo sapiens_hsa034501.38563543
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.31493169
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17720976
27Influenza A_Homo sapiens_hsa051641.13278247
28Chronic myeloid leukemia_Homo sapiens_hsa052201.12348203
29Osteoclast differentiation_Homo sapiens_hsa043801.10621244
30Viral carcinogenesis_Homo sapiens_hsa052031.08909094
31Hepatitis C_Homo sapiens_hsa051601.07961788
32Bladder cancer_Homo sapiens_hsa052191.07450005
33Epstein-Barr virus infection_Homo sapiens_hsa051691.05212007
34HTLV-I infection_Homo sapiens_hsa051661.02957565
35Sulfur relay system_Homo sapiens_hsa041221.01973035
36Antigen processing and presentation_Homo sapiens_hsa046121.01043307
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00918297
38Toxoplasmosis_Homo sapiens_hsa051451.00308155
39Selenocompound metabolism_Homo sapiens_hsa004500.99973667
40Pentose phosphate pathway_Homo sapiens_hsa000300.99744754
41Leishmaniasis_Homo sapiens_hsa051400.99513116
42Lysosome_Homo sapiens_hsa041420.98091280
43Acute myeloid leukemia_Homo sapiens_hsa052210.98039095
44Prion diseases_Homo sapiens_hsa050200.97463571
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96844334
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.96459008
47MicroRNAs in cancer_Homo sapiens_hsa052060.96258004
48Small cell lung cancer_Homo sapiens_hsa052220.95568435
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93994365
50Vibrio cholerae infection_Homo sapiens_hsa051100.92805844
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92283423
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.91707271
53Systemic lupus erythematosus_Homo sapiens_hsa053220.90165269
54Thyroid cancer_Homo sapiens_hsa052160.90081573
55Basal transcription factors_Homo sapiens_hsa030220.89695644
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.88568445
57mTOR signaling pathway_Homo sapiens_hsa041500.85431983
58Herpes simplex infection_Homo sapiens_hsa051680.85242065
59TNF signaling pathway_Homo sapiens_hsa046680.83305859
60Folate biosynthesis_Homo sapiens_hsa007900.79868448
61Basal cell carcinoma_Homo sapiens_hsa052170.79687710
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77535659
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75618981
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75237844
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75042326
66Tuberculosis_Homo sapiens_hsa051520.74639252
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73444029
68Non-small cell lung cancer_Homo sapiens_hsa052230.73393646
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73318723
70Salmonella infection_Homo sapiens_hsa051320.73204311
71Purine metabolism_Homo sapiens_hsa002300.73185663
72Apoptosis_Homo sapiens_hsa042100.72939670
73Carbon metabolism_Homo sapiens_hsa012000.72122200
74Colorectal cancer_Homo sapiens_hsa052100.69346627
75Hippo signaling pathway_Homo sapiens_hsa043900.68998850
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68527393
77Oocyte meiosis_Homo sapiens_hsa041140.66167528
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65835661
79Hepatitis B_Homo sapiens_hsa051610.63836933
80Notch signaling pathway_Homo sapiens_hsa043300.63796625
81Hedgehog signaling pathway_Homo sapiens_hsa043400.63359065
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62023995
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61493919
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61045954
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59474334
86Primary immunodeficiency_Homo sapiens_hsa053400.57573038
87Allograft rejection_Homo sapiens_hsa053300.57373363
88Fructose and mannose metabolism_Homo sapiens_hsa000510.56296618
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.55946318
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55941722
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.55531629
92Endocytosis_Homo sapiens_hsa041440.55387363
93HIF-1 signaling pathway_Homo sapiens_hsa040660.54888497
94Prostate cancer_Homo sapiens_hsa052150.54586248
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53982147
96Endometrial cancer_Homo sapiens_hsa052130.53398891
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.53208669
98Proteoglycans in cancer_Homo sapiens_hsa052050.53094648
99Shigellosis_Homo sapiens_hsa051310.52212072
100AMPK signaling pathway_Homo sapiens_hsa041520.50431614
101Prolactin signaling pathway_Homo sapiens_hsa049170.50120779
102Pancreatic cancer_Homo sapiens_hsa052120.49063260
103Lysine degradation_Homo sapiens_hsa003100.48598674
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.46923792
105Pathways in cancer_Homo sapiens_hsa052000.45329209
106Viral myocarditis_Homo sapiens_hsa054160.44398515
107N-Glycan biosynthesis_Homo sapiens_hsa005100.44385706
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43231200
109Measles_Homo sapiens_hsa051620.43137621
110Adherens junction_Homo sapiens_hsa045200.39018517
111Legionellosis_Homo sapiens_hsa051340.38731063
112TGF-beta signaling pathway_Homo sapiens_hsa043500.38621064
113Renal cell carcinoma_Homo sapiens_hsa052110.35909114
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35073545
115VEGF signaling pathway_Homo sapiens_hsa043700.33589271
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.33589041
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33077189
118B cell receptor signaling pathway_Homo sapiens_hsa046620.32640858
119Glioma_Homo sapiens_hsa052140.32275028
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31982111
121T cell receptor signaling pathway_Homo sapiens_hsa046600.30976244
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30557532
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29118453
124Insulin signaling pathway_Homo sapiens_hsa049100.25592356
125Melanoma_Homo sapiens_hsa052180.25488815
126Alcoholism_Homo sapiens_hsa050340.24878448
127Galactose metabolism_Homo sapiens_hsa000520.24162223
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.24076351
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23505902
130Vitamin B6 metabolism_Homo sapiens_hsa007500.23136920

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