INTS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.34469214
2protein K11-linked deubiquitination (GO:0035871)7.12848807
3nuclear pore complex assembly (GO:0051292)6.29416105
4synaptonemal complex assembly (GO:0007130)6.08770973
5male meiosis (GO:0007140)6.02936381
6nuclear pore organization (GO:0006999)5.97004373
7synaptonemal complex organization (GO:0070193)5.84070501
8DNA methylation involved in gamete generation (GO:0043046)5.51007411
9histone H3-K4 trimethylation (GO:0080182)5.50847671
10UDP-N-acetylglucosamine metabolic process (GO:0006047)5.20167695
11rRNA catabolic process (GO:0016075)5.16251862
12mitotic sister chromatid cohesion (GO:0007064)5.14000137
13cilium or flagellum-dependent cell motility (GO:0001539)4.94498763
14meiotic chromosome segregation (GO:0045132)4.88466523
15tryptophan catabolic process (GO:0006569)4.88016153
16indole-containing compound catabolic process (GO:0042436)4.88016153
17indolalkylamine catabolic process (GO:0046218)4.88016153
18peptidyl-threonine dephosphorylation (GO:0035970)4.86213101
19chromosome organization involved in meiosis (GO:0070192)4.85859064
20pore complex assembly (GO:0046931)4.74632810
21fusion of sperm to egg plasma membrane (GO:0007342)4.67094976
22kynurenine metabolic process (GO:0070189)4.58772061
23regulation of MHC class II biosynthetic process (GO:0045346)4.57329436
24regulation of histone H3-K9 methylation (GO:0051570)4.52902201
25monoubiquitinated protein deubiquitination (GO:0035520)4.52629160
26interkinetic nuclear migration (GO:0022027)4.51358885
27L-fucose catabolic process (GO:0042355)4.47907259
28fucose catabolic process (GO:0019317)4.47907259
29L-fucose metabolic process (GO:0042354)4.47907259
30meiotic nuclear division (GO:0007126)4.47085027
31regulation of meiosis I (GO:0060631)4.47000895
32male meiosis I (GO:0007141)4.35662114
33sister chromatid cohesion (GO:0007062)4.33484214
34gene silencing by RNA (GO:0031047)4.31461977
35tryptophan metabolic process (GO:0006568)4.12323449
36indolalkylamine metabolic process (GO:0006586)3.96027357
37sperm-egg recognition (GO:0035036)3.95260611
38peptidyl-lysine trimethylation (GO:0018023)3.90879992
39protein K48-linked deubiquitination (GO:0071108)3.89896269
40positive regulation of triglyceride biosynthetic process (GO:0010867)3.88923169
41sperm motility (GO:0030317)3.81199658
42binding of sperm to zona pellucida (GO:0007339)3.79959623
43DNA synthesis involved in DNA repair (GO:0000731)3.77354773
44regulation of centriole replication (GO:0046599)3.73870887
45acrosome assembly (GO:0001675)3.73603309
46inner ear receptor stereocilium organization (GO:0060122)3.71182404
47DNA replication-dependent nucleosome assembly (GO:0006335)3.70992620
48DNA replication-dependent nucleosome organization (GO:0034723)3.70992620
49spermatid development (GO:0007286)3.68362646
50behavioral response to nicotine (GO:0035095)3.64108401
51auditory receptor cell stereocilium organization (GO:0060088)3.63993668
52cell-cell recognition (GO:0009988)3.63284294
53motile cilium assembly (GO:0044458)3.62927913
54reciprocal DNA recombination (GO:0035825)3.62144996
55reciprocal meiotic recombination (GO:0007131)3.62144996
56mitotic chromosome condensation (GO:0007076)3.60883890
57meiotic cell cycle process (GO:1903046)3.60848807
58response to pheromone (GO:0019236)3.57387827
59interleukin-6-mediated signaling pathway (GO:0070102)3.57052139
60meiosis I (GO:0007127)3.56541246
61cellular response to exogenous dsRNA (GO:0071360)3.52439711
62mitochondrion degradation (GO:0000422)3.49464043
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.48395232
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48395232
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48395232
66photoreceptor cell maintenance (GO:0045494)3.47776955
67protein K6-linked ubiquitination (GO:0085020)3.47591802
68regulation of DNA endoreduplication (GO:0032875)3.45683686
69mitotic nuclear envelope disassembly (GO:0007077)3.45026339
70cell wall macromolecule metabolic process (GO:0044036)3.44302913
71cell wall macromolecule catabolic process (GO:0016998)3.44302913
72multicellular organism reproduction (GO:0032504)3.43742104
73ncRNA catabolic process (GO:0034661)3.41821539
74protein K63-linked deubiquitination (GO:0070536)3.40711450
75kinetochore organization (GO:0051383)3.40315000
76meiotic cell cycle (GO:0051321)3.39515307
77histone exchange (GO:0043486)3.37683934
78microtubule depolymerization (GO:0007019)3.34585596
79gene silencing (GO:0016458)3.34478494
80regulation of RNA export from nucleus (GO:0046831)3.34123142
81regulation of protein polyubiquitination (GO:1902914)3.31770337
82chromatin remodeling at centromere (GO:0031055)3.31108814
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29011868
84detection of light stimulus involved in visual perception (GO:0050908)3.28904232
85detection of light stimulus involved in sensory perception (GO:0050962)3.28904232
86DNA methylation (GO:0006306)3.26297021
87DNA alkylation (GO:0006305)3.26297021
88axonemal dynein complex assembly (GO:0070286)3.25157832
89peptidyl-lysine methylation (GO:0018022)3.24403795
90plasma membrane fusion (GO:0045026)3.22747832
91membrane disassembly (GO:0030397)3.21444531
92nuclear envelope disassembly (GO:0051081)3.21444531
93regulation of triglyceride biosynthetic process (GO:0010866)3.19835243
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.19754148
95positive regulation of histone H3-K4 methylation (GO:0051571)3.17012935
96phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16511400
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.16318135
98regulation of translation, ncRNA-mediated (GO:0045974)3.16318135
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.16318135
100sulfation (GO:0051923)3.16133771
101attachment of spindle microtubules to kinetochore (GO:0008608)3.15392852
102nerve growth factor signaling pathway (GO:0038180)3.14418378
103positive regulation of defense response to virus by host (GO:0002230)3.14069912
104DNA packaging (GO:0006323)3.12539003
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12368469
106female gamete generation (GO:0007292)3.11033946
107negative regulation of DNA repair (GO:0045738)3.10642730
108C-terminal protein lipidation (GO:0006501)3.09565690
109positive regulation of chromosome segregation (GO:0051984)3.08952259
110double-strand break repair via homologous recombination (GO:0000724)3.07726840
111regulation of helicase activity (GO:0051095)3.07282325
112resolution of meiotic recombination intermediates (GO:0000712)3.05191935
113recombinational repair (GO:0000725)3.03447633
114histone H3-K9 methylation (GO:0051567)3.02600649
115pre-miRNA processing (GO:0031054)3.00854850
116CENP-A containing nucleosome assembly (GO:0034080)2.99414759
117negative regulation of mast cell activation (GO:0033004)2.99164835
118DNA replication-independent nucleosome assembly (GO:0006336)2.98211972
119DNA replication-independent nucleosome organization (GO:0034724)2.98211972
120negative regulation of histone methylation (GO:0031061)2.96582810
121negative regulation of systemic arterial blood pressure (GO:0003085)2.95793055
122germ cell development (GO:0007281)2.95022401
123neural tube formation (GO:0001841)2.95013853
124synapsis (GO:0007129)2.94297928
125heterochromatin organization (GO:0070828)2.93838278
126genitalia morphogenesis (GO:0035112)2.93680053
127tachykinin receptor signaling pathway (GO:0007217)2.93241999
128rRNA methylation (GO:0031167)2.92808285
129chromatin assembly (GO:0031497)2.92581519
130chromosome organization (GO:0051276)2.92463885
131centriole replication (GO:0007099)2.91966805
132regulation of centrosome cycle (GO:0046605)2.91310107
133chromosome condensation (GO:0030261)2.91227663
134positive regulation of fatty acid oxidation (GO:0046321)2.90560119
135metaphase plate congression (GO:0051310)2.89814122
136nucleus organization (GO:0006997)2.88044699
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88037469
138regulation of hippo signaling (GO:0035330)2.87710273
139mismatch repair (GO:0006298)2.87163352
140mitotic metaphase plate congression (GO:0007080)2.86764222
141epithelial cilium movement (GO:0003351)2.86520777
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.86299398
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86299398
144DNA geometric change (GO:0032392)2.86286884
145translesion synthesis (GO:0019985)2.85861748
146positive regulation of fatty acid beta-oxidation (GO:0032000)2.84560630
147DNA duplex unwinding (GO:0032508)2.84356942
148regulation of sister chromatid cohesion (GO:0007063)2.83309762
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.82470944
150DNA conformation change (GO:0071103)2.82034499
151pericardium development (GO:0060039)2.81862228
152chromatin assembly or disassembly (GO:0006333)2.81469940
153replicative senescence (GO:0090399)2.80878710
154cAMP catabolic process (GO:0006198)2.80719888
155centriole assembly (GO:0098534)2.80316629
156acrosome reaction (GO:0007340)2.80226161
157regulation of chromosome segregation (GO:0051983)2.79809927
158male gamete generation (GO:0048232)2.79786336
159C-terminal protein amino acid modification (GO:0018410)2.78483881
160Golgi to endosome transport (GO:0006895)2.77875868
161regulation of memory T cell differentiation (GO:0043380)2.74232315
162cellular response to ethanol (GO:0071361)2.73115099
163positive regulation of digestive system process (GO:0060456)2.71333013
164establishment of protein localization to Golgi (GO:0072600)2.70387641
165oxidative demethylation (GO:0070989)2.69699613
166somite development (GO:0061053)2.66963921
167replication fork processing (GO:0031297)2.65582140
168positive regulation of vasculogenesis (GO:2001214)2.63834691
169drug catabolic process (GO:0042737)2.61711860
170histone H3-K4 methylation (GO:0051568)2.61537796
171phosphatidylserine acyl-chain remodeling (GO:0036150)2.60295628
172cyclic nucleotide catabolic process (GO:0009214)2.59710782
1733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59026105
174purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59026105
175thyroid hormone metabolic process (GO:0042403)2.58154007
176regulation of fatty acid oxidation (GO:0046320)2.57680991
177indole-containing compound metabolic process (GO:0042430)2.57032191
178granulocyte differentiation (GO:0030851)2.56118059
179amine catabolic process (GO:0009310)2.55467819
180cellular biogenic amine catabolic process (GO:0042402)2.55467819
181phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.54915236
182regulation of gene silencing by RNA (GO:0060966)2.51817669
183regulation of posttranscriptional gene silencing (GO:0060147)2.51817669
184regulation of gene silencing by miRNA (GO:0060964)2.51817669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.86982605
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.69999227
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89644899
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84063989
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.72448051
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37325750
7GBX2_23144817_ChIP-Seq_PC3_Human3.16971016
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.09872890
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09682416
10ZNF274_21170338_ChIP-Seq_K562_Hela3.04184906
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89540652
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83433706
13TAF15_26573619_Chip-Seq_HEK293_Human2.77113366
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.58947020
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50304997
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48058528
17VDR_22108803_ChIP-Seq_LS180_Human2.39661670
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.22725919
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22163165
20AR_21909140_ChIP-Seq_LNCAP_Human2.08328816
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07951614
22ER_23166858_ChIP-Seq_MCF-7_Human1.97957522
23P300_19829295_ChIP-Seq_ESCs_Human1.97036701
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90652129
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.85287855
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83291602
27* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.79747829
28IGF1R_20145208_ChIP-Seq_DFB_Human1.79675936
29* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76794817
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76791964
31* TCF4_23295773_ChIP-Seq_U87_Human1.74996434
32BCAT_22108803_ChIP-Seq_LS180_Human1.73451248
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.71766515
34STAT3_23295773_ChIP-Seq_U87_Human1.69257959
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.68687710
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68156319
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64240378
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63930170
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63661853
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58536312
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57234167
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56611359
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55088768
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54494923
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54494923
46* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54337710
47* CBP_20019798_ChIP-Seq_JUKART_Human1.54337710
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53842053
49SMAD4_21799915_ChIP-Seq_A2780_Human1.52935672
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.52348598
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51335876
52IRF1_19129219_ChIP-ChIP_H3396_Human1.51202026
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50582424
54VDR_23849224_ChIP-Seq_CD4+_Human1.48030761
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47310249
56AR_21572438_ChIP-Seq_LNCaP_Human1.47123838
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43342960
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42753626
59ELK1_19687146_ChIP-ChIP_HELA_Human1.42488582
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40416493
61AR_25329375_ChIP-Seq_VCAP_Human1.40315045
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39536113
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39382458
64TP53_16413492_ChIP-PET_HCT116_Human1.37529150
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.36550219
66CDX2_22108803_ChIP-Seq_LS180_Human1.36346881
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35679504
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30849204
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30709922
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30492024
71AHR_22903824_ChIP-Seq_MCF-7_Human1.30403405
72FUS_26573619_Chip-Seq_HEK293_Human1.30044553
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.29786519
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26672740
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.25253128
76EWS_26573619_Chip-Seq_HEK293_Human1.25187774
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24949842
78KDM5A_27292631_Chip-Seq_BREAST_Human1.24067557
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23664223
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22872202
81RUNX2_22187159_ChIP-Seq_PCA_Human1.22687712
82TCF4_22108803_ChIP-Seq_LS180_Human1.22334874
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21674211
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21359511
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20789687
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.20585673
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.20040227
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19744105
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.19296854
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19160963
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17948166
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16059639
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.15720948
94TP53_22573176_ChIP-Seq_HFKS_Human1.15290702
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15122514
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.15040239
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12961686
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.12380254
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11035695
100NANOG_19829295_ChIP-Seq_ESCs_Human1.10935723
101SOX2_19829295_ChIP-Seq_ESCs_Human1.10935723
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10615185
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.10615185
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10181693
105HOXB7_26014856_ChIP-Seq_BT474_Human1.09955031
106FOXP3_21729870_ChIP-Seq_TREG_Human1.09809225
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08590175
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07942659
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06505534
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06085047
111MYB_26560356_Chip-Seq_TH1_Human1.05062541
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04113158
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03795663
114KDM2B_26808549_Chip-Seq_REH_Human1.03572836
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03498489
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03477414
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03065313
118* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03062131
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02685104
120SMAD_19615063_ChIP-ChIP_OVARY_Human1.01047111
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.01037437
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.00752086
123PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00722284
124ETV1_20927104_ChIP-Seq_GIST48_Human1.00388902
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00050124
126MYC_18940864_ChIP-ChIP_HL60_Human0.99723455
127AR_20517297_ChIP-Seq_VCAP_Human0.99709480
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.99409547
129WDR5_24793694_ChIP-Seq_LNCAP_Human0.98848229
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97848128
131* CJUN_26792858_Chip-Seq_BT549_Human0.97750890
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96030150
133* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95753683
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95362298
135MYB_26560356_Chip-Seq_TH2_Human0.94996361
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.94868214
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94849650
138* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94786526
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88260838
140* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87657877
141TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86803242
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83969817
143* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83414297
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82388089
145CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82078622
146* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81971157
147ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81970383
148ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81789314
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81516807
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81111090
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.79704607
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78739832
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78121774
154KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76788731
155KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76788731
156KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76788731
157MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76315877
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76240876
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.75004911
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.73160835
161ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.70998445
162* XRN2_22483619_ChIP-Seq_HELA_Human0.70939465
163MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70758586
164TTF2_22483619_ChIP-Seq_HELA_Human0.70500981
165MYC_22102868_ChIP-Seq_BL_Human0.70469144
166DCP1A_22483619_ChIP-Seq_HELA_Human0.70253169
167IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68429800
168* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.68209060
169GABP_19822575_ChIP-Seq_HepG2_Human0.67174839
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.66810984
171GATA1_26923725_Chip-Seq_HPCs_Mouse0.66517849
172SCL_19346495_ChIP-Seq_HPC-7_Human0.66121027
173NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.66091618
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.65663070
175* TFEB_21752829_ChIP-Seq_HELA_Human0.65653635
176NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.65143138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.72955895
2MP0008057_abnormal_DNA_replication4.91269494
3MP0005410_abnormal_fertilization3.73108394
4MP0010094_abnormal_chromosome_stability3.73062099
5MP0003195_calcinosis3.50273599
6MP0008058_abnormal_DNA_repair3.46107284
7MP0005646_abnormal_pituitary_gland3.40499511
8MP0005310_abnormal_salivary_gland3.14865458
9MP0003111_abnormal_nucleus_morphology3.06513494
10MP0001929_abnormal_gametogenesis2.85546178
11MP0002210_abnormal_sex_determination2.73946032
12MP0005551_abnormal_eye_electrophysiolog2.71589914
13MP0003077_abnormal_cell_cycle2.67472632
14MP0008007_abnormal_cellular_replicative2.58254409
15MP0002876_abnormal_thyroid_physiology2.44378619
16MP0005085_abnormal_gallbladder_physiolo2.42433856
17MP0003693_abnormal_embryo_hatching2.41311699
18MP0003698_abnormal_male_reproductive2.38465023
19MP0004484_altered_response_of2.32122093
20MP0006072_abnormal_retinal_apoptosis2.28992771
21MP0003646_muscle_fatigue2.26013973
22MP0001145_abnormal_male_reproductive2.24774461
23MP0004957_abnormal_blastocyst_morpholog2.23053990
24MP0004043_abnormal_pH_regulation2.18615537
25MP0003786_premature_aging2.16675081
26MP0010307_abnormal_tumor_latency2.14717023
27MP0008995_early_reproductive_senescence2.13216141
28MP0003011_delayed_dark_adaptation2.02696433
29MP0000653_abnormal_sex_gland2.02528071
30MP0000383_abnormal_hair_follicle2.02108858
31MP0005253_abnormal_eye_physiology1.96889657
32MP0003136_yellow_coat_color1.94114228
33MP0004808_abnormal_hematopoietic_stem1.89213837
34MP0000631_abnormal_neuroendocrine_gland1.80560795
35MP0008872_abnormal_physiological_respon1.78002487
36MP0009764_decreased_sensitivity_to1.76973176
37MP0002396_abnormal_hematopoietic_system1.68160540
38MP0010352_gastrointestinal_tract_polyps1.65913936
39MP0003123_paternal_imprinting1.62099660
40MP0003121_genomic_imprinting1.61188293
41MP0005174_abnormal_tail_pigmentation1.59974718
42MP0003718_maternal_effect1.59778596
43MP0000372_irregular_coat_pigmentation1.56986600
44MP0003890_abnormal_embryonic-extraembry1.56933688
45MP0003787_abnormal_imprinting1.56759414
46MP0002254_reproductive_system_inflammat1.54753678
47MP0002009_preneoplasia1.49970621
48MP0000350_abnormal_cell_proliferation1.49497508
49MP0001730_embryonic_growth_arrest1.49486844
50MP0000569_abnormal_digit_pigmentation1.44622867
51MP0002138_abnormal_hepatobiliary_system1.43866571
52MP0001324_abnormal_eye_pigmentation1.43393646
53MP0005365_abnormal_bile_salt1.41924386
54MP0003763_abnormal_thymus_physiology1.40733103
55MP0005076_abnormal_cell_differentiation1.40652471
56MP0004130_abnormal_muscle_cell1.40115439
57MP0009780_abnormal_chondrocyte_physiolo1.39802655
58MP0005167_abnormal_blood-brain_barrier1.39466859
59MP0001672_abnormal_embryogenesis/_devel1.35189075
60MP0005380_embryogenesis_phenotype1.35189075
61MP0004215_abnormal_myocardial_fiber1.34698394
62MP0005645_abnormal_hypothalamus_physiol1.34693569
63MP0004885_abnormal_endolymph1.34310155
64MP0009745_abnormal_behavioral_response1.33244757
65MP0002161_abnormal_fertility/fecundity1.32462232
66MP0008875_abnormal_xenobiotic_pharmacok1.29002354
67MP0004197_abnormal_fetal_growth/weight/1.28581186
68MP0003984_embryonic_growth_retardation1.28405006
69MP0001119_abnormal_female_reproductive1.27050299
70MP0003045_fibrosis1.25106445
71MP0002086_abnormal_extraembryonic_tissu1.24744426
72MP0002088_abnormal_embryonic_growth/wei1.24022064
73MP0001545_abnormal_hematopoietic_system1.23859293
74MP0005397_hematopoietic_system_phenotyp1.23859293
75MP0003943_abnormal_hepatobiliary_system1.23748827
76MP0008932_abnormal_embryonic_tissue1.22776513
77MP0001764_abnormal_homeostasis1.21959098
78MP0009046_muscle_twitch1.21297832
79MP0010678_abnormal_skin_adnexa1.19954090
80MP0002938_white_spotting1.19933518
81MP0001501_abnormal_sleep_pattern1.19701412
82MP0005187_abnormal_penis_morphology1.19668920
83MP0002084_abnormal_developmental_patter1.19266855
84MP0001293_anophthalmia1.17780773
85MP0001697_abnormal_embryo_size1.17728116
86MP0004133_heterotaxia1.17118940
87MP0005647_abnormal_sex_gland1.12618224
88MP0005360_urolithiasis1.11343960
89MP0005395_other_phenotype1.10918181
90MP0002168_other_aberrant_phenotype1.09779820
91MP0006292_abnormal_olfactory_placode1.08853479
92MP0002160_abnormal_reproductive_system1.07542163
93MP0004264_abnormal_extraembryonic_tissu1.06413818
94MP0002085_abnormal_embryonic_tissue1.06362499
95MP0009278_abnormal_bone_marrow1.06110067
96MP0005623_abnormal_meninges_morphology1.03770256
97MP0002693_abnormal_pancreas_physiology1.03267980
98MP0008961_abnormal_basal_metabolism1.01972675
99MP0001915_intracranial_hemorrhage1.01116497
100MP0001986_abnormal_taste_sensitivity1.00919785
101MP0006054_spinal_hemorrhage1.00410578
102MP0002166_altered_tumor_susceptibility1.00326814
103MP0000313_abnormal_cell_death0.99839570
104MP0004742_abnormal_vestibular_system0.98865970
105MP0002398_abnormal_bone_marrow0.97683739
106MP0000516_abnormal_urinary_system0.96911473
107MP0005367_renal/urinary_system_phenotyp0.96911473
108MP0000427_abnormal_hair_cycle0.96761315
109MP0005332_abnormal_amino_acid0.96681426
110MP0002006_tumorigenesis0.96309805
111MP0005220_abnormal_exocrine_pancreas0.96028348
112MP0002019_abnormal_tumor_incidence0.93486183
113MP0005195_abnormal_posterior_eye0.93468836
114MP0004381_abnormal_hair_follicle0.93190622
115MP0000703_abnormal_thymus_morphology0.92714650
116MP0002080_prenatal_lethality0.92346044
117MP0003937_abnormal_limbs/digits/tail_de0.91532289
118MP0000230_abnormal_systemic_arterial0.90959468
119MP0005389_reproductive_system_phenotype0.89738542
120MP0000490_abnormal_crypts_of0.89413242
121MP0000647_abnormal_sebaceous_gland0.88407667
122MP0005171_absent_coat_pigmentation0.87856411
123MP0002837_dystrophic_cardiac_calcinosis0.87595707
124MP0001666_abnormal_nutrient_absorption0.86672282
125MP0003252_abnormal_bile_duct0.86534929
126MP0002092_abnormal_eye_morphology0.85550252
127MP0002102_abnormal_ear_morphology0.85097144
128MP0009703_decreased_birth_body0.84299260
129MP0001485_abnormal_pinna_reflex0.83216167
130MP0010329_abnormal_lipoprotein_level0.81561088
131MP0003567_abnormal_fetal_cardiomyocyte0.81159701
132MP0002557_abnormal_social/conspecific_i0.80537348
133MP0009643_abnormal_urine_homeostasis0.79583962
134MP0001968_abnormal_touch/_nociception0.79373511
135MP0002697_abnormal_eye_size0.78474198
136MP0000015_abnormal_ear_pigmentation0.78092853
137MP0004147_increased_porphyrin_level0.77634077
138MP0001873_stomach_inflammation0.76980273
139MP0002095_abnormal_skin_pigmentation0.76866690
140MP0003936_abnormal_reproductive_system0.75658659
141MP0003699_abnormal_female_reproductive0.75436510
142MP0002638_abnormal_pupillary_reflex0.75259113
143MP0000432_abnormal_head_morphology0.73949721
144MP0002722_abnormal_immune_system0.73938545
145MP0000689_abnormal_spleen_morphology0.73516802
146MP0001800_abnormal_humoral_immune0.72712202
147MP0008775_abnormal_heart_ventricle0.72518387
148MP0010386_abnormal_urinary_bladder0.70689241
149MP0004084_abnormal_cardiac_muscle0.69258841
150MP0005391_vision/eye_phenotype0.69133030
151MP0004142_abnormal_muscle_tone0.68604115
152MP0002751_abnormal_autonomic_nervous0.68184436
153MP0005448_abnormal_energy_balance0.67506299
154MP0009697_abnormal_copulation0.66281680
155MP0002272_abnormal_nervous_system0.65944487
156MP0003115_abnormal_respiratory_system0.65509888
157MP0002405_respiratory_system_inflammati0.65500223
158MP0001835_abnormal_antigen_presentation0.65454246
159MP0002653_abnormal_ependyma_morphology0.65027570
160MP0000716_abnormal_immune_system0.64220734
161MP0002925_abnormal_cardiovascular_devel0.63590747
162MP0004134_abnormal_chest_morphology0.63251144
163MP0005621_abnormal_cell_physiology0.63035386
164MP0002429_abnormal_blood_cell0.63022751
165MP0002928_abnormal_bile_duct0.63002087
166MP0009672_abnormal_birth_weight0.60331787
167MP0001286_abnormal_eye_development0.60018059
168MP0005671_abnormal_response_to0.59948149
169MP0005384_cellular_phenotype0.59166278
170MP0005248_abnormal_Harderian_gland0.58705684
171MP0005408_hypopigmentation0.56908735
172MP0000537_abnormal_urethra_morphology0.56581588
173MP0003941_abnormal_skin_development0.56346745
174MP0002452_abnormal_antigen_presenting0.56243698
175MP0003935_abnormal_craniofacial_develop0.55460708

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.02378127
2Absent/shortened dynein arms (HP:0200106)4.41175873
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.41175873
4Pancreatic cysts (HP:0001737)4.40163467
5Chromsome breakage (HP:0040012)4.01213591
6Congenital stationary night blindness (HP:0007642)3.99910170
7Abnormal spermatogenesis (HP:0008669)3.91422128
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91229853
9Attenuation of retinal blood vessels (HP:0007843)3.81533735
10Pancreatic fibrosis (HP:0100732)3.81319072
11Abnormal rod and cone electroretinograms (HP:0008323)3.79198082
12True hermaphroditism (HP:0010459)3.69010889
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.62342730
14Azoospermia (HP:0000027)3.51734460
15Abnormality of chromosome stability (HP:0003220)3.50295956
16Ectopic kidney (HP:0000086)3.41645726
17Decreased central vision (HP:0007663)3.39041996
18Gonadotropin excess (HP:0000837)3.36069773
19Volvulus (HP:0002580)3.30426165
20Impulsivity (HP:0100710)3.27699815
21Pigmentary retinal degeneration (HP:0001146)3.26735277
22Tubular atrophy (HP:0000092)3.25353699
2311 pairs of ribs (HP:0000878)3.22097179
24Gaze-evoked nystagmus (HP:0000640)3.03950248
25Decreased circulating renin level (HP:0003351)3.01726340
26Bile duct proliferation (HP:0001408)3.00583888
27Abnormal biliary tract physiology (HP:0012439)3.00583888
28Bony spicule pigmentary retinopathy (HP:0007737)2.89301973
29Rhinitis (HP:0012384)2.88595786
30Abnormal respiratory motile cilium physiology (HP:0012261)2.86791200
31Choroideremia (HP:0001139)2.86039177
32Thyroid-stimulating hormone excess (HP:0002925)2.84927568
33Abnormality of the fingertips (HP:0001211)2.83318553
34Abnormal respiratory motile cilium morphology (HP:0005938)2.79335159
35Abnormal respiratory epithelium morphology (HP:0012253)2.79335159
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.77275494
37Polydipsia (HP:0001959)2.75567196
38Abnormal drinking behavior (HP:0030082)2.75567196
39Cerebellar dysplasia (HP:0007033)2.74699435
40Abnormality of the preputium (HP:0100587)2.73379363
41Abnormality of alanine metabolism (HP:0010916)2.72607831
42Hyperalaninemia (HP:0003348)2.72607831
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72607831
44Nephronophthisis (HP:0000090)2.69735725
45Type II lissencephaly (HP:0007260)2.66591756
46Papillary thyroid carcinoma (HP:0002895)2.63189107
47Cystic liver disease (HP:0006706)2.63096049
48Meckel diverticulum (HP:0002245)2.61807550
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.53970220
50Genetic anticipation (HP:0003743)2.49502088
51Medulloblastoma (HP:0002885)2.48505882
52Abnormality of the ileum (HP:0001549)2.44846875
53Tubulointerstitial nephritis (HP:0001970)2.38546349
54Acute myeloid leukemia (HP:0004808)2.38271065
55Sloping forehead (HP:0000340)2.37603818
56Congenital hepatic fibrosis (HP:0002612)2.36781963
57Supernumerary spleens (HP:0009799)2.35096860
58Hyperventilation (HP:0002883)2.35028938
59Myelodysplasia (HP:0002863)2.34882692
60Fibular hypoplasia (HP:0003038)2.34497719
61Prominent nose (HP:0000448)2.34295777
62Furrowed tongue (HP:0000221)2.31842809
63Nephroblastoma (Wilms tumor) (HP:0002667)2.31515861
64Hyperkalemia (HP:0002153)2.29882026
65Hypoplasia of the pons (HP:0012110)2.29762182
66Duodenal stenosis (HP:0100867)2.29250323
67Small intestinal stenosis (HP:0012848)2.29250323
68Progressive inability to walk (HP:0002505)2.27699394
69Abnormality of the carotid arteries (HP:0005344)2.26952445
70Abnormality of the pons (HP:0007361)2.26920246
71Clumsiness (HP:0002312)2.26566873
72Chronic bronchitis (HP:0004469)2.25713146
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24665431
74Infertility (HP:0000789)2.23361748
75Embryonal renal neoplasm (HP:0011794)2.21974045
76Long eyelashes (HP:0000527)2.21010498
77Bronchiectasis (HP:0002110)2.19992751
78Selective tooth agenesis (HP:0001592)2.19657894
79Progressive cerebellar ataxia (HP:0002073)2.19002272
80Abnormality of the renal medulla (HP:0100957)2.18429798
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.18269416
82Truncal obesity (HP:0001956)2.15982972
83Missing ribs (HP:0000921)2.13383163
84Protruding tongue (HP:0010808)2.12378909
85Fair hair (HP:0002286)2.11184760
86Inability to walk (HP:0002540)2.10839357
87Bronchitis (HP:0012387)2.08772102
88Increased corneal curvature (HP:0100692)2.08713523
89Keratoconus (HP:0000563)2.08713523
90Nasal polyposis (HP:0100582)2.08528229
91Clubbing of toes (HP:0100760)2.08379335
92Abolished electroretinogram (ERG) (HP:0000550)2.08048211
93Abnormality of macular pigmentation (HP:0008002)2.08044351
94Deep philtrum (HP:0002002)2.02981585
95Oligodactyly (hands) (HP:0001180)2.02949794
96Degeneration of anterior horn cells (HP:0002398)2.02433546
97Abnormality of the anterior horn cell (HP:0006802)2.02433546
98Abnormal ciliary motility (HP:0012262)2.02042094
99Birth length less than 3rd percentile (HP:0003561)2.01116856
100Flat occiput (HP:0005469)2.00415966
101Duplicated collecting system (HP:0000081)1.99911581
102Recurrent bronchitis (HP:0002837)1.97478073
103Medial flaring of the eyebrow (HP:0010747)1.96656830
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.96269172
105Hypoplasia of the fovea (HP:0007750)1.96269172
106Anencephaly (HP:0002323)1.95963145
107Chorioretinal atrophy (HP:0000533)1.95929198
108Astigmatism (HP:0000483)1.95873839
109Central scotoma (HP:0000603)1.95703857
110Intestinal atresia (HP:0011100)1.95287269
111Polyuria (HP:0000103)1.94557368
112Congenital sensorineural hearing impairment (HP:0008527)1.93033826
113Rhabdomyosarcoma (HP:0002859)1.92907774
114Abnormality of the duodenum (HP:0002246)1.92449365
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.92066706
116Heterotopia (HP:0002282)1.91652480
117Pendular nystagmus (HP:0012043)1.90999912
118Glioma (HP:0009733)1.90040487
119Molar tooth sign on MRI (HP:0002419)1.89936365
120Abnormality of midbrain morphology (HP:0002418)1.89936365
121Deviation of the thumb (HP:0009603)1.89879182
122Retinitis pigmentosa (HP:0000510)1.89534486
123Small hand (HP:0200055)1.85705890
124Severe visual impairment (HP:0001141)1.85472023
125Proximal placement of thumb (HP:0009623)1.84861990
126Absent thumb (HP:0009777)1.84008997
127Renal cortical cysts (HP:0000803)1.83135816
128Broad-based gait (HP:0002136)1.82916634
129Retrobulbar optic neuritis (HP:0100654)1.80607905
130Optic neuritis (HP:0100653)1.80607905
131Facial cleft (HP:0002006)1.80095100
132Low anterior hairline (HP:0000294)1.80040046
133Abnormal lung lobation (HP:0002101)1.79459737
134Breast carcinoma (HP:0003002)1.79427097
135Sandal gap (HP:0001852)1.79163642
136Sclerocornea (HP:0000647)1.79115834
137Chronic hepatic failure (HP:0100626)1.78748656
138Febrile seizures (HP:0002373)1.78515932
139Increased nuchal translucency (HP:0010880)1.78359208
140Bone marrow hypocellularity (HP:0005528)1.77881220
141Colon cancer (HP:0003003)1.77877021
142Astrocytoma (HP:0009592)1.77009737
143Abnormality of the astrocytes (HP:0100707)1.77009737
144Aqueductal stenosis (HP:0002410)1.76604673
145Short hallux (HP:0010109)1.75948272
146Postaxial foot polydactyly (HP:0001830)1.74968646
147Concave nail (HP:0001598)1.74961595
148Abnormality of the renal collecting system (HP:0004742)1.73340771
149Generalized hypopigmentation of hair (HP:0011358)1.73326198
150Male infertility (HP:0003251)1.72627476
151Abnormality of the nasal septum (HP:0000419)1.72216640
152Oligohydramnios (HP:0001562)1.71843473
153Scotoma (HP:0000575)1.71655060
154Biliary tract neoplasm (HP:0100574)1.71399115
1552-3 toe syndactyly (HP:0004691)1.71350116
156Neoplasm of the oral cavity (HP:0100649)1.70967207
157Abnormal biliary tract morphology (HP:0012440)1.70323956
158Hypoplastic nipples (HP:0002557)1.70131153
159Absent frontal sinuses (HP:0002688)1.69620926
160Recurrent sinusitis (HP:0011108)1.68542554
161Thyroid carcinoma (HP:0002890)1.68469110
162Enlarged kidneys (HP:0000105)1.68419520
163Short thumb (HP:0009778)1.67284593
164Capillary hemangiomas (HP:0005306)1.66424858
165Ependymoma (HP:0002888)1.65049028
166Hypoplastic labia majora (HP:0000059)1.63823471
167IgA deficiency (HP:0002720)1.63687275
168Cafe-au-lait spot (HP:0000957)1.63596022
169Abnormality of the renal cortex (HP:0011035)1.61739683
170Upper motor neuron abnormality (HP:0002127)1.61714433
171T lymphocytopenia (HP:0005403)1.61579627
172Abnormality of the labia minora (HP:0012880)1.61440556
173Amaurosis fugax (HP:0100576)1.61170148
174Agnosia (HP:0010524)1.60864974
175Urethral obstruction (HP:0000796)1.59418499
176Abnormality of the lower motor neuron (HP:0002366)1.58018477
177Oligodactyly (HP:0012165)1.57091107
178Supernumerary ribs (HP:0005815)1.56857862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.85124300
2CDK124.18149370
3CDC73.86199798
4PDK43.08409858
5PDK33.08409858
6NEK22.93776842
7CAMKK22.82937125
8BRD42.56308743
9BMPR1B2.55215065
10ACVR1B2.25181578
11PDK22.15770217
12WNK32.10200878
13WEE12.08848594
14LATS12.05200129
15ADRBK22.04560581
16MAP3K92.01762191
17PLK41.97153567
18STK31.95769177
19SRPK11.88005619
20DYRK31.83915448
21WNK41.79159748
22ATR1.77794630
23ZAK1.75801045
24GRK11.68962512
25TTK1.67860319
26NUAK11.48727539
27MKNK21.48003584
28CHEK11.47831654
29BRSK21.45070061
30ATM1.41838676
31MKNK11.37624117
32FRK1.34069614
33PASK1.32258567
34CHEK21.32253708
35PLK11.30327185
36STK41.29859718
37MAP3K141.28148329
38EPHA41.23266429
39MELK1.22161888
40TSSK61.21395799
41VRK11.19893294
42PLK31.19009431
43CDK91.14978618
44EEF2K1.11521472
45FLT31.11208030
46ICK1.10973302
47CDK71.10394420
48OXSR11.09147235
49PIM11.08090486
50CHUK1.07577632
51AURKB1.07528950
52CAMK1D1.07046326
53PNCK1.04605303
54EIF2AK31.04470216
55RPS6KB21.04183668
56MAP4K11.04070760
57TNIK1.03644323
58TXK1.02981764
59STK38L0.98992904
60CAMK40.97481861
61CDK40.95799977
62PDK10.95555913
63MAPK130.95486629
64STK100.95283230
65NLK0.94335322
66RPS6KA40.93360556
67MAPKAPK50.90886092
68CAMK1G0.90095543
69TLK10.88157893
70ADRBK10.88036138
71PINK10.87481291
72FER0.86244184
73CDK60.85885754
74MAP4K20.85795092
75JAK30.85664420
76TAOK30.83475365
77YES10.82324220
78CDK20.81275906
79FGFR20.78949439
80CDK30.77738567
81DAPK20.75836688
82PIK3CG0.75695577
83STK390.75414594
84PRKCE0.74255808
85TNK20.72739902
86ERBB30.71928838
87CDK10.71258954
88AKT30.71239954
89CDK80.71091935
90PDPK10.71090398
91MTOR0.70696756
92EIF2AK10.70101897
93TEC0.69286135
94MAP3K40.69109563
95MAP3K30.67478872
96PAK30.66439940
97RPS6KA50.66292125
98TYK20.65894486
99SGK20.65027880
100EIF2AK20.63262753
101RPS6KB10.62844665
102TRIM280.62454165
103IRAK40.61927326
104TRPM70.61849460
105FGFR30.60885166
106TESK10.60839254
107HIPK20.58289141
108PDGFRB0.56778705
109IRAK10.56150941
110PRKCQ0.54492553
111NTRK30.53979378
112IKBKB0.53686283
113MARK30.52779245
114EPHA20.52384876
115CSNK1D0.50530569
116PLK20.50463270
117MAP2K30.49176963
118SGK30.48531611
119CLK10.48423401
120PRKAA20.47508935
121PRKDC0.47385447
122WNK10.47282326
123MAP3K80.47212611
124TYRO30.46671834
125CAMK10.46231145
126TGFBR10.46215635
127INSRR0.45441193
128MAPK140.45214830
129CAMKK10.43108353
130STK110.42296941
131CSF1R0.40737356
132NEK60.40167554
133MAPK10.40057452
134ITK0.39684393
135PTK2B0.39344160
136MET0.39278299
137PRKCI0.38276004
138STK240.37995041
139GSK3B0.37262594
140PRKAA10.36705780
141SGK10.36705139
142MAPKAPK30.35832517
143CASK0.34742660
144ERBB20.34564432
145STK380.33853720
146EPHA30.32557939
147MUSK0.31915743
148SGK2230.30472130
149SGK4940.30472130
150FGFR10.29426398
151PIK3CA0.29254815
152PKN10.28897588

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29041638
2Fanconi anemia pathway_Homo sapiens_hsa034603.26732842
3Linoleic acid metabolism_Homo sapiens_hsa005913.16607682
4Regulation of autophagy_Homo sapiens_hsa041403.15952503
5Basal transcription factors_Homo sapiens_hsa030223.04077279
6Mismatch repair_Homo sapiens_hsa034302.97898675
7Caffeine metabolism_Homo sapiens_hsa002322.95955699
8DNA replication_Homo sapiens_hsa030302.94492635
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90680438
10Homologous recombination_Homo sapiens_hsa034402.87336523
11RNA transport_Homo sapiens_hsa030132.77350509
12Cell cycle_Homo sapiens_hsa041102.64634259
13Propanoate metabolism_Homo sapiens_hsa006402.48242962
14mRNA surveillance pathway_Homo sapiens_hsa030152.43980069
15Non-homologous end-joining_Homo sapiens_hsa034502.30239527
16RNA degradation_Homo sapiens_hsa030182.22496761
17Ether lipid metabolism_Homo sapiens_hsa005652.20237024
18Base excision repair_Homo sapiens_hsa034102.19747424
19Spliceosome_Homo sapiens_hsa030402.18140835
20One carbon pool by folate_Homo sapiens_hsa006702.16106022
21Phototransduction_Homo sapiens_hsa047442.11473022
22Systemic lupus erythematosus_Homo sapiens_hsa053222.06197148
23Nucleotide excision repair_Homo sapiens_hsa034201.99431020
24Tryptophan metabolism_Homo sapiens_hsa003801.88216647
25Nitrogen metabolism_Homo sapiens_hsa009101.84805892
26RNA polymerase_Homo sapiens_hsa030201.65006180
27Herpes simplex infection_Homo sapiens_hsa051681.64145461
28Butanoate metabolism_Homo sapiens_hsa006501.59439039
29Selenocompound metabolism_Homo sapiens_hsa004501.54806127
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54536955
31Antigen processing and presentation_Homo sapiens_hsa046121.53458607
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51988761
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49894614
34p53 signaling pathway_Homo sapiens_hsa041151.47215873
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.46137383
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45816531
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44906676
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43996260
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.43688143
40Viral carcinogenesis_Homo sapiens_hsa052031.41143380
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.36653917
42Taste transduction_Homo sapiens_hsa047421.32290004
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31723431
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.31117532
45Fatty acid degradation_Homo sapiens_hsa000711.30891785
46Ovarian steroidogenesis_Homo sapiens_hsa049131.26582182
47Pyrimidine metabolism_Homo sapiens_hsa002401.26203377
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22063194
49ABC transporters_Homo sapiens_hsa020101.19098599
50MicroRNAs in cancer_Homo sapiens_hsa052061.16542644
51Measles_Homo sapiens_hsa051621.16394425
52Vitamin B6 metabolism_Homo sapiens_hsa007501.15846231
53HTLV-I infection_Homo sapiens_hsa051661.14429401
54Epstein-Barr virus infection_Homo sapiens_hsa051691.13000669
55Small cell lung cancer_Homo sapiens_hsa052221.12896426
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12663278
57Morphine addiction_Homo sapiens_hsa050321.11789887
58Nicotine addiction_Homo sapiens_hsa050331.11644621
59Fatty acid metabolism_Homo sapiens_hsa012121.11189600
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10777239
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08533338
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08391445
63Primary immunodeficiency_Homo sapiens_hsa053400.99801005
64Prostate cancer_Homo sapiens_hsa052150.99284268
65Circadian rhythm_Homo sapiens_hsa047100.99167599
66TGF-beta signaling pathway_Homo sapiens_hsa043500.98362125
67Oocyte meiosis_Homo sapiens_hsa041140.98352112
68Retinol metabolism_Homo sapiens_hsa008300.96845319
69Serotonergic synapse_Homo sapiens_hsa047260.96057944
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95877709
71Lysine degradation_Homo sapiens_hsa003100.95863330
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95731065
73Adherens junction_Homo sapiens_hsa045200.94393336
74Influenza A_Homo sapiens_hsa051640.93318675
75Arachidonic acid metabolism_Homo sapiens_hsa005900.92204180
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.89934326
77Olfactory transduction_Homo sapiens_hsa047400.89859565
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88910354
79Purine metabolism_Homo sapiens_hsa002300.86954203
80Glutamatergic synapse_Homo sapiens_hsa047240.86237622
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85994160
82T cell receptor signaling pathway_Homo sapiens_hsa046600.84758262
83Chemical carcinogenesis_Homo sapiens_hsa052040.84711920
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83332526
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82116867
86Allograft rejection_Homo sapiens_hsa053300.81030379
87PPAR signaling pathway_Homo sapiens_hsa033200.80399162
88Dorso-ventral axis formation_Homo sapiens_hsa043200.79627514
89Legionellosis_Homo sapiens_hsa051340.78502765
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76479250
91B cell receptor signaling pathway_Homo sapiens_hsa046620.76125339
92Insulin secretion_Homo sapiens_hsa049110.75645190
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75437431
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74182029
95Toxoplasmosis_Homo sapiens_hsa051450.74180553
96Fatty acid biosynthesis_Homo sapiens_hsa000610.74163616
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.73621101
98Hepatitis B_Homo sapiens_hsa051610.72709780
99Calcium signaling pathway_Homo sapiens_hsa040200.72522621
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71931671
101Alcoholism_Homo sapiens_hsa050340.71083920
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.70494922
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70414358
104Long-term depression_Homo sapiens_hsa047300.68560975
105Sulfur metabolism_Homo sapiens_hsa009200.67983680
106Graft-versus-host disease_Homo sapiens_hsa053320.67600012
107Staphylococcus aureus infection_Homo sapiens_hsa051500.65526169
108Basal cell carcinoma_Homo sapiens_hsa052170.64987971
109FoxO signaling pathway_Homo sapiens_hsa040680.64619551
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64482808
111Fat digestion and absorption_Homo sapiens_hsa049750.64342581
112Hematopoietic cell lineage_Homo sapiens_hsa046400.63651741
113Sphingolipid metabolism_Homo sapiens_hsa006000.63364847
114Apoptosis_Homo sapiens_hsa042100.61555118
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61530928
116TNF signaling pathway_Homo sapiens_hsa046680.60809343
117Chronic myeloid leukemia_Homo sapiens_hsa052200.60724866
118Steroid biosynthesis_Homo sapiens_hsa001000.60053022
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.59864728
120Thyroid cancer_Homo sapiens_hsa052160.59595187
121Glycerolipid metabolism_Homo sapiens_hsa005610.59022778
122Hippo signaling pathway_Homo sapiens_hsa043900.57025878
123Mineral absorption_Homo sapiens_hsa049780.54760959
124Acute myeloid leukemia_Homo sapiens_hsa052210.54595441
125Pancreatic cancer_Homo sapiens_hsa052120.54075494
126Salivary secretion_Homo sapiens_hsa049700.53292271
127Autoimmune thyroid disease_Homo sapiens_hsa053200.51942217
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51899727
129Pentose phosphate pathway_Homo sapiens_hsa000300.51816963
130Circadian entrainment_Homo sapiens_hsa047130.50134112
131MAPK signaling pathway_Homo sapiens_hsa040100.50004260
132Vitamin digestion and absorption_Homo sapiens_hsa049770.49728635
133Inositol phosphate metabolism_Homo sapiens_hsa005620.48682669
134Histidine metabolism_Homo sapiens_hsa003400.48610885
135Colorectal cancer_Homo sapiens_hsa052100.48366617
136Notch signaling pathway_Homo sapiens_hsa043300.47438993
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47383166
138Asthma_Homo sapiens_hsa053100.46140663
139Pyruvate metabolism_Homo sapiens_hsa006200.45897855
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45756453
141Renin secretion_Homo sapiens_hsa049240.45370412
142GABAergic synapse_Homo sapiens_hsa047270.44871361
143Pathways in cancer_Homo sapiens_hsa052000.44440016
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42767896
145Wnt signaling pathway_Homo sapiens_hsa043100.41993797
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40626416
147ECM-receptor interaction_Homo sapiens_hsa045120.40479631
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40431575
149Osteoclast differentiation_Homo sapiens_hsa043800.39813545
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39293400
151Proteasome_Homo sapiens_hsa030500.38970346
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37577736
153Protein export_Homo sapiens_hsa030600.37167737
154Hepatitis C_Homo sapiens_hsa051600.37098083
155Cholinergic synapse_Homo sapiens_hsa047250.35710514
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35424818
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35308478
158Viral myocarditis_Homo sapiens_hsa054160.35065421
159Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34540056
160cAMP signaling pathway_Homo sapiens_hsa040240.33978262
161Glucagon signaling pathway_Homo sapiens_hsa049220.33408365
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33309739
163Hedgehog signaling pathway_Homo sapiens_hsa043400.32943477
164N-Glycan biosynthesis_Homo sapiens_hsa005100.32604360
165Leukocyte transendothelial migration_Homo sapiens_hsa046700.32341905
166Shigellosis_Homo sapiens_hsa051310.32232179
167Cysteine and methionine metabolism_Homo sapiens_hsa002700.31367760
168Endometrial cancer_Homo sapiens_hsa052130.30222422
169Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29018167
170Leishmaniasis_Homo sapiens_hsa051400.27163602
171Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26750328
172mTOR signaling pathway_Homo sapiens_hsa041500.24741698
173Focal adhesion_Homo sapiens_hsa045100.23207751

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »