INTS6L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.96101015
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.34718864
3negative regulation of cell killing (GO:0031342)6.34718864
4regulation of B cell receptor signaling pathway (GO:0050855)5.81357580
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.07350649
6regulation of gamma-delta T cell activation (GO:0046643)4.93877417
7response to interleukin-15 (GO:0070672)4.86564208
8regulation of gamma-delta T cell differentiation (GO:0045586)4.85618002
9negative thymic T cell selection (GO:0045060)4.85023992
10activated T cell proliferation (GO:0050798)4.80899014
11negative T cell selection (GO:0043383)4.77817240
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76165617
13negative regulation of T cell mediated immunity (GO:0002710)4.51090408
14cellular response to interleukin-15 (GO:0071350)4.49639261
15B cell receptor signaling pathway (GO:0050853)4.46350216
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.31427841
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.25551419
18positive T cell selection (GO:0043368)4.21163310
19positive regulation of granulocyte differentiation (GO:0030854)4.20841225
20antigen processing and presentation of endogenous antigen (GO:0019883)4.19185680
21regulation of B cell differentiation (GO:0045577)4.19170173
22positive regulation of B cell differentiation (GO:0045579)4.18726578
23positive thymic T cell selection (GO:0045059)4.14413004
24interferon-gamma production (GO:0032609)4.13416275
25T cell selection (GO:0045058)3.96952867
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93118893
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.89549063
28T cell migration (GO:0072678)3.86698724
29cellular extravasation (GO:0045123)3.79296639
30thymic T cell selection (GO:0045061)3.72895417
31negative regulation of erythrocyte differentiation (GO:0045647)3.70501565
32regulation of isotype switching to IgG isotypes (GO:0048302)3.63376110
33response to muramyl dipeptide (GO:0032495)3.63315337
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57059291
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.57059291
36modulation by symbiont of host immune response (GO:0052553)3.57059291
37positive regulation by symbiont of host defense response (GO:0052509)3.57059291
38modulation by symbiont of host defense response (GO:0052031)3.57059291
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57059291
40mast cell activation (GO:0045576)3.54996382
41leukocyte aggregation (GO:0070486)3.54485818
42histone H3-K4 trimethylation (GO:0080182)3.52221996
43regulation of alpha-beta T cell proliferation (GO:0046640)3.48523820
44histone H3-K36 demethylation (GO:0070544)3.39183853
45tolerance induction (GO:0002507)3.30265930
46T cell proliferation (GO:0042098)3.26544547
47B cell homeostasis (GO:0001782)3.22311786
48regulation of T cell tolerance induction (GO:0002664)3.20609156
49antigen receptor-mediated signaling pathway (GO:0050851)3.19995509
50negative regulation of leukocyte mediated immunity (GO:0002704)3.19881410
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18970994
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.18761213
53regulation of regulatory T cell differentiation (GO:0045589)3.18113280
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17678623
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.17213870
56negative regulation of interleukin-12 production (GO:0032695)3.17086948
57detection of other organism (GO:0098543)3.16719283
58mast cell activation involved in immune response (GO:0002279)3.16329416
59mast cell degranulation (GO:0043303)3.16329416
60T cell homeostasis (GO:0043029)3.15361704
61regulation of tolerance induction (GO:0002643)3.14834856
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11808899
63negative regulation of T-helper cell differentiation (GO:0045623)3.11721875
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11721875
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10807547
66response to peptidoglycan (GO:0032494)3.10046970
67macrophage activation involved in immune response (GO:0002281)3.08928561
68positive regulation of isotype switching (GO:0045830)3.07886771
69detection of bacterium (GO:0016045)3.06795439
70defense response to protozoan (GO:0042832)3.05643436
71regulation of natural killer cell mediated immunity (GO:0002715)3.05057554
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05057554
73positive regulation of interleukin-2 production (GO:0032743)3.04119378
74neutrophil activation involved in immune response (GO:0002283)3.03615406
75negative regulation of adaptive immune response (GO:0002820)3.02346715
76peptidyl-lysine trimethylation (GO:0018023)3.00942395
77myeloid cell activation involved in immune response (GO:0002275)2.98760835
78microglial cell activation (GO:0001774)2.97984174
79leukocyte degranulation (GO:0043299)2.94646363
80regulation of interferon-beta biosynthetic process (GO:0045357)2.93890137
81lymphocyte homeostasis (GO:0002260)2.93123669
82phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.93016103
83germinal center formation (GO:0002467)2.92057125
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89476012
85regulation of granulocyte differentiation (GO:0030852)2.88311829
86T cell receptor signaling pathway (GO:0050852)2.87137594
87positive regulation of tolerance induction (GO:0002645)2.86638869
88Peyers patch development (GO:0048541)2.83914988
89mucosal-associated lymphoid tissue development (GO:0048537)2.83914988
90respiratory burst (GO:0045730)2.79949327
91response to protozoan (GO:0001562)2.77797835
92regulation of histone H3-K27 methylation (GO:0061085)2.77581080
93type I interferon signaling pathway (GO:0060337)2.77182592
94cellular response to type I interferon (GO:0071357)2.77182592
95response to type I interferon (GO:0034340)2.77016571
96megakaryocyte development (GO:0035855)2.75186933
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74319466
98regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.74209371
99interferon-gamma-mediated signaling pathway (GO:0060333)2.74151632
100positive regulation of B cell activation (GO:0050871)2.74107795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.64482095
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25305411
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.24937561
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.33821052
5RUNX_20019798_ChIP-Seq_JUKART_Human3.44004806
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39961808
7MYB_26560356_Chip-Seq_TH2_Human3.32737406
8SCL_19346495_ChIP-Seq_HPC-7_Human3.30276816
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23431770
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19961815
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.13494391
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.92023463
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89845082
14GATA1_22025678_ChIP-Seq_K562_Human2.88266539
15MYB_26560356_Chip-Seq_TH1_Human2.81630334
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68619556
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66669021
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.51035154
19SPI1_23547873_ChIP-Seq_NB4_Human2.50465260
20MYC_22102868_ChIP-Seq_BL_Human2.46350701
21MAF_26560356_Chip-Seq_TH1_Human2.44210124
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31799354
23GATA3_27048872_Chip-Seq_THYMUS_Human2.27868767
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15614498
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13328438
26UTX_26944678_Chip-Seq_JUKART_Human2.08806931
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.01493236
28SPI1_23127762_ChIP-Seq_K562_Human2.00910800
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99476729
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90063676
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89023711
32GATA3_26560356_Chip-Seq_TH2_Human1.88543049
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79508161
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79171753
35CIITA_25753668_ChIP-Seq_RAJI_Human1.78527507
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76182155
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74306864
38VDR_24763502_ChIP-Seq_THP-1_Human1.70830798
39VDR_21846776_ChIP-Seq_THP-1_Human1.70757287
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70019132
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.67470254
42MAF_26560356_Chip-Seq_TH2_Human1.66123837
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63327116
44VDR_24787735_ChIP-Seq_THP-1_Human1.62833081
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.60076184
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.57899861
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50960820
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50782818
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45710464
50TCF7_22412390_ChIP-Seq_EML_Mouse1.45331954
51GATA1_19941826_ChIP-Seq_K562_Human1.29196389
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28381068
53PU_27001747_Chip-Seq_BMDM_Mouse1.27378561
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.25972500
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24265580
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23654161
57KDM2B_26808549_Chip-Seq_DND41_Human1.23497301
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20043480
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18747202
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18576794
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15983956
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.11658410
63VDR_23849224_ChIP-Seq_CD4+_Human1.09539107
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08458687
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07736549
66GATA2_19941826_ChIP-Seq_K562_Human1.05652772
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03257143
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02431463
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02056883
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01214953
71SMRT_27268052_Chip-Seq_Bcells_Human0.99954600
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98530386
73KDM2B_26808549_Chip-Seq_JURKAT_Human0.97890706
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93201787
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92541602
76GATA3_26560356_Chip-Seq_TH1_Human0.92096260
77ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91582328
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88315938
79RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87924043
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.87791403
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.83560230
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82913922
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82653093
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82308530
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82213552
86NCOR1_26117541_ChIP-Seq_K562_Human0.81309489
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80310515
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79653095
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79229911
90FOXP3_21729870_ChIP-Seq_TREG_Human0.76181083
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75220320
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74774813
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.74684369
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70543942
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70433319
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70322517
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70248461
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70202091
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.67480233
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.66831136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.16834291
2MP0005671_abnormal_response_to3.96714764
3MP0003763_abnormal_thymus_physiology3.82169893
4MP0001800_abnormal_humoral_immune3.52521054
5MP0003724_increased_susceptibility_to3.25302248
6MP0003436_decreased_susceptibility_to3.10700569
7MP0005000_abnormal_immune_tolerance2.96304460
8MP0001790_abnormal_immune_system2.78017886
9MP0005387_immune_system_phenotype2.78017886
10MP0002723_abnormal_immune_serum2.75652202
11MP0000685_abnormal_immune_system2.73429966
12MP0002420_abnormal_adaptive_immunity2.68076282
13MP0001819_abnormal_immune_cell2.64822166
14MP0002452_abnormal_antigen_presenting2.63268932
15MP0003303_peritoneal_inflammation2.58916526
16MP0002398_abnormal_bone_marrow2.54055446
17MP0005025_abnormal_response_to2.48926522
18MP0002396_abnormal_hematopoietic_system2.48882469
19MP0006082_CNS_inflammation2.48522021
20MP0009785_altered_susceptibility_to2.46568007
21MP0002419_abnormal_innate_immunity2.39969798
22MP0002405_respiratory_system_inflammati2.25148477
23MP0000703_abnormal_thymus_morphology2.24462999
24MP0000716_abnormal_immune_system2.23556389
25MP0002009_preneoplasia2.11195663
26MP0000689_abnormal_spleen_morphology2.09834437
27MP0002722_abnormal_immune_system2.07373595
28MP0003300_gastrointestinal_ulcer2.03780957
29MP0003787_abnormal_imprinting1.95510403
30MP0008057_abnormal_DNA_replication1.95088102
31MP0005075_abnormal_melanosome_morpholog1.87442034
32MP0002166_altered_tumor_susceptibility1.82575210
33MP0002429_abnormal_blood_cell1.79419991
34MP0010155_abnormal_intestine_physiology1.79355047
35MP0001873_stomach_inflammation1.77694057
36MP0009333_abnormal_splenocyte_physiolog1.77531247
37MP0002148_abnormal_hypersensitivity_rea1.69856736
38MP0000465_gastrointestinal_hemorrhage1.66856352
39MP0003866_abnormal_defecation1.65482780
40MP0001845_abnormal_inflammatory_respons1.57400816
41MP0002132_abnormal_respiratory_system1.55970137
42MP0005464_abnormal_platelet_physiology1.50986052
43MP0000569_abnormal_digit_pigmentation1.49569137
44MP0003172_abnormal_lysosome_physiology1.45848873
45MP0003656_abnormal_erythrocyte_physiolo1.44750595
46MP0004947_skin_inflammation1.44631894
47MP0004381_abnormal_hair_follicle1.44585312
48MP0005310_abnormal_salivary_gland1.39677803
49MP0001545_abnormal_hematopoietic_system1.35515870
50MP0005397_hematopoietic_system_phenotyp1.35515870
51MP0003828_pulmonary_edema1.34868689
52MP0003045_fibrosis1.31851686
53MP0003221_abnormal_cardiomyocyte_apopto1.26938264
54MP0002006_tumorigenesis1.23905616
55MP0009278_abnormal_bone_marrow1.22216345
56MP0009764_decreased_sensitivity_to1.18201846
57MP0004808_abnormal_hematopoietic_stem1.12539383
58MP0001533_abnormal_skeleton_physiology1.12245026
59MP0008995_early_reproductive_senescence1.05340833
60MP0008469_abnormal_protein_level1.03963690
61MP0001851_eye_inflammation1.02788690
62MP0004147_increased_porphyrin_level0.98242227
63MP0008877_abnormal_DNA_methylation0.98198060
64MP0004883_abnormal_blood_vessel0.89489894
65MP0000858_altered_metastatic_potential0.87150327
66MP0001853_heart_inflammation0.84165921
67MP0008260_abnormal_autophagy0.83917947
68MP0002277_abnormal_respiratory_mucosa0.83530423
69MP0002019_abnormal_tumor_incidence0.82109353
70MP0002653_abnormal_ependyma_morphology0.73921652
71MP0000015_abnormal_ear_pigmentation0.71891616
72MP0001663_abnormal_digestive_system0.68604293
73MP0009765_abnormal_xenobiotic_induced0.68030752
74MP0002998_abnormal_bone_remodeling0.65916833
75MP0009763_increased_sensitivity_to0.65437657
76MP0002933_joint_inflammation0.65256628
77MP0001986_abnormal_taste_sensitivity0.59592036
78MP0003690_abnormal_glial_cell0.58874689
79MP0004264_abnormal_extraembryonic_tissu0.58272220
80MP0004510_myositis0.52378410
81MP0002928_abnormal_bile_duct0.51985275
82MP0002133_abnormal_respiratory_system0.51535393
83MP0005388_respiratory_system_phenotype0.51535393
84MP0005451_abnormal_body_composition0.51339204
85MP0002102_abnormal_ear_morphology0.51292774
86MP0005174_abnormal_tail_pigmentation0.51238526
87MP0005645_abnormal_hypothalamus_physiol0.51187085
88MP0004142_abnormal_muscle_tone0.50686116
89MP0004145_abnormal_muscle_electrophysio0.48124937
90MP0000371_diluted_coat_color0.47326907
91MP0002095_abnormal_skin_pigmentation0.44754224
92MP0005076_abnormal_cell_differentiation0.44262649
93MP0000249_abnormal_blood_vessel0.43411671
94MP0008961_abnormal_basal_metabolism0.43161624
95MP0002083_premature_death0.42852961
96MP0004742_abnormal_vestibular_system0.42490612
97MP0000313_abnormal_cell_death0.42476362
98MP0010307_abnormal_tumor_latency0.42234105
99MP0000490_abnormal_crypts_of0.42202500
100MP0002127_abnormal_cardiovascular_syste0.41699498

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.89801569
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.72949197
3Abnormality of T cell number (HP:0011839)4.49186268
4Stomatitis (HP:0010280)4.39916845
5Recurrent cutaneous fungal infections (HP:0011370)4.38254580
6Chronic mucocutaneous candidiasis (HP:0002728)4.38254580
7Panhypogammaglobulinemia (HP:0003139)4.37125720
8Abnormality of T cells (HP:0002843)4.25221655
9Recurrent fungal infections (HP:0002841)4.19371680
10Eczematoid dermatitis (HP:0000976)4.15717248
11Recurrent bacterial skin infections (HP:0005406)4.15655311
12Myositis (HP:0100614)3.94221995
13Recurrent abscess formation (HP:0002722)3.84676481
14Elevated erythrocyte sedimentation rate (HP:0003565)3.84226103
15Recurrent viral infections (HP:0004429)3.77262554
16Abnormality of T cell physiology (HP:0011840)3.75030712
17Encephalitis (HP:0002383)3.69324390
18Meningitis (HP:0001287)3.68608058
19Abnormality of the fingertips (HP:0001211)3.65857326
20Agammaglobulinemia (HP:0004432)3.56414900
21Optic neuritis (HP:0100653)3.53214472
22Retrobulbar optic neuritis (HP:0100654)3.53214472
23Colitis (HP:0002583)3.51914523
24IgM deficiency (HP:0002850)3.43557295
25Inflammation of the large intestine (HP:0002037)3.39099622
26Mediastinal lymphadenopathy (HP:0100721)3.35972870
27Gastrointestinal infarctions (HP:0005244)3.35752438
28Gastrointestinal inflammation (HP:0004386)3.29619267
29Recurrent skin infections (HP:0001581)3.26761659
30Hypochromic microcytic anemia (HP:0004840)3.21048395
31Recurrent bronchitis (HP:0002837)3.20261984
32Vasculitis (HP:0002633)3.15046393
33Orchitis (HP:0100796)3.09272663
34Autoimmune hemolytic anemia (HP:0001890)3.01644883
35Spontaneous hematomas (HP:0007420)3.01271956
36Chronic diarrhea (HP:0002028)3.00828200
37Severe combined immunodeficiency (HP:0004430)3.00089933
38IgG deficiency (HP:0004315)2.93190108
39Chest pain (HP:0100749)2.78405177
40Chronic obstructive pulmonary disease (HP:0006510)2.78245490
41Obstructive lung disease (HP:0006536)2.78245490
42Leukocytosis (HP:0001974)2.76334826
43Abnormality of macrophages (HP:0004311)2.72347522
44Keratoconjunctivitis sicca (HP:0001097)2.70578060
45Papilledema (HP:0001085)2.68976594
46Recurrent gram-negative bacterial infections (HP:0005420)2.67554927
47Pulmonary infiltrates (HP:0002113)2.65945551
48Pustule (HP:0200039)2.65257130
49Lymphopenia (HP:0001888)2.61619945
50Hemoptysis (HP:0002105)2.60304430
51Abnormality of eosinophils (HP:0001879)2.58919269
52Volvulus (HP:0002580)2.58721695
53Granulocytopenia (HP:0001913)2.58389597
54Keratoconjunctivitis (HP:0001096)2.58317873
55Viral hepatitis (HP:0006562)2.55751574
56Recurrent sinusitis (HP:0011108)2.48825228
57Nasal polyposis (HP:0100582)2.45127946
58Combined immunodeficiency (HP:0005387)2.40536417
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.38869009
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.38406591
61Gastrointestinal stroma tumor (HP:0100723)2.35740381
62Prolonged bleeding time (HP:0003010)2.34148515
63Arterial thrombosis (HP:0004420)2.32035591
64Hypochromic anemia (HP:0001931)2.31714387
65Gingivitis (HP:0000230)2.27329302
66Urticaria (HP:0001025)2.24347829
67Eosinophilia (HP:0001880)2.23600408
68Increased IgM level (HP:0003496)2.22431925
69Amaurosis fugax (HP:0100576)2.21320604
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19293079
71Acute myeloid leukemia (HP:0004808)2.18642907
72Basal cell carcinoma (HP:0002671)2.18331839
73Abnormality of the prostate (HP:0008775)2.17337063
74Microcytic anemia (HP:0001935)2.10491796
75Pulmonary embolism (HP:0002204)2.08103754
76Abnormality of the columella (HP:0009929)2.07861860
77IgA deficiency (HP:0002720)2.07700779
78Lymphoma (HP:0002665)2.07128817
79Osteomyelitis (HP:0002754)2.04091190
80Bronchitis (HP:0012387)2.03961343
81Stomach cancer (HP:0012126)2.03348600
82Epistaxis (HP:0000421)2.02774082
83Increased IgE level (HP:0003212)2.02638574
84Cellulitis (HP:0100658)2.00330188
85Abnormality of B cell number (HP:0010975)1.99419852
86Verrucae (HP:0200043)1.99282720
87Papilloma (HP:0012740)1.99282720
88Poikilocytosis (HP:0004447)1.99131056
89Neoplasm of the tracheobronchial system (HP:0100552)1.96768165
90Thyroiditis (HP:0100646)1.92953698
91Abnormal hair whorl (HP:0010721)1.88486361
92Keratitis (HP:0000491)1.87393378
93Sepsis (HP:0100806)1.87144286
94B lymphocytopenia (HP:0010976)1.86529725
95Hypergammaglobulinemia (HP:0010702)1.85049609
96Hypoplasia of the thymus (HP:0000778)1.84954799
97Gangrene (HP:0100758)1.84910853
98Acute hepatic failure (HP:0006554)1.84479623
99Neonatal hypoglycemia (HP:0001998)1.80442129
100Thrombocytosis (HP:0001894)1.80312773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.18759212
2RIPK44.30074826
3MAP4K14.19058589
4TXK3.65860094
5ITK2.39067459
6FES2.36370672
7TYK22.23372590
8BTK2.20897652
9MAP3K142.20385142
10BLK2.18532097
11PRPF4B2.04708643
12IKBKE1.90725663
13JAK31.90037731
14SYK1.88931699
15ZAP701.79777061
16BRD41.75285062
17TEC1.72916436
18IRAK41.69999736
19CSK1.67459698
20BMPR21.64645250
21TNK21.61826942
22GRK61.60924075
23JAK11.59039104
24KIT1.43327048
25TBK11.42393179
26MAP2K31.37077409
27LCK1.36103234
28LYN1.34889281
29HCK1.33702003
30SIK31.31047848
31JAK21.25501768
32MAP3K131.22105624
33MARK31.21526295
34MAP4K21.20310900
35MAP3K71.20200571
36MAP3K101.14417728
37CSF1R1.06708859
38IKBKB1.03003197
39PKN21.02430885
40PASK1.01960093
41FGR0.97239717
42MATK0.89777105
43MAPK70.89300851
44CDK40.88698453
45PIM10.87589714
46NUAK10.87236882
47MAPK130.86646473
48YES10.85493302
49FGFR30.85120845
50PIK3CG0.84056114
51SIK20.83911934
52SGK20.82587851
53CAMKK20.79800326
54CAMK40.74837945
55PRKCQ0.73658300
56HIPK20.68498017
57MARK20.65414844
58CDK120.65126424
59KSR20.64502645
60PTK2B0.60698121
61WNK10.60002961
62IRAK10.58837276
63RET0.57220487
64CAMKK10.54179406
65MAP3K20.51594113
66MAP3K60.51289511
67FRK0.50962407
68CDK60.50240541
69UHMK10.50085524
70NLK0.49445353
71TRPM70.49413071
72SGK30.48673579
73PDK10.47929353
74FYN0.47262047
75STK40.45489710
76CDK30.45421097
77MAP3K40.44943006
78IRAK20.44658969
79DYRK1B0.43654450
80MAP2K20.41841795
81SCYL20.41265116
82RAF10.41134076
83EPHA30.40622388
84MAPK120.40009493
85DYRK30.39557337
86STK100.39200793
87GRK70.39027853
88MAP3K10.38997919
89CDK190.35890635
90KSR10.35155765
91LATS10.34232120
92STK110.33088962
93SGK4940.32072546
94SGK2230.32072546
95PIK3CA0.30454441
96PRKCH0.30447259
97TAOK10.30116601
98RPS6KC10.29752429
99RPS6KL10.29752429
100PRKAA20.29370984

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.21679129
2Graft-versus-host disease_Homo sapiens_hsa053322.92914749
3Allograft rejection_Homo sapiens_hsa053302.64795067
4B cell receptor signaling pathway_Homo sapiens_hsa046622.53191854
5Autoimmune thyroid disease_Homo sapiens_hsa053202.52127494
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.45347128
7T cell receptor signaling pathway_Homo sapiens_hsa046602.45233631
8Leishmaniasis_Homo sapiens_hsa051402.42298187
9Osteoclast differentiation_Homo sapiens_hsa043802.25559517
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25393676
11Type I diabetes mellitus_Homo sapiens_hsa049402.14784949
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.11651117
13Measles_Homo sapiens_hsa051622.09232980
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.00091578
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92300034
16Asthma_Homo sapiens_hsa053101.90206924
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81687672
18Antigen processing and presentation_Homo sapiens_hsa046121.80268808
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74853965
20Acute myeloid leukemia_Homo sapiens_hsa052211.68938839
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66835006
22Hematopoietic cell lineage_Homo sapiens_hsa046401.63196380
23Viral myocarditis_Homo sapiens_hsa054161.61035816
24Herpes simplex infection_Homo sapiens_hsa051681.59985793
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.59634659
26Tuberculosis_Homo sapiens_hsa051521.53125693
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49701033
28Staphylococcus aureus infection_Homo sapiens_hsa051501.49418932
29Influenza A_Homo sapiens_hsa051641.45799350
30Toxoplasmosis_Homo sapiens_hsa051451.44654414
31Non-small cell lung cancer_Homo sapiens_hsa052231.38087117
32Hepatitis B_Homo sapiens_hsa051611.37989938
33Chemokine signaling pathway_Homo sapiens_hsa040621.35670379
34Malaria_Homo sapiens_hsa051441.28759890
35TNF signaling pathway_Homo sapiens_hsa046681.14728037
36Prolactin signaling pathway_Homo sapiens_hsa049171.08929530
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07214783
38Chronic myeloid leukemia_Homo sapiens_hsa052201.04064457
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00562889
40Epstein-Barr virus infection_Homo sapiens_hsa051691.00279846
41Platelet activation_Homo sapiens_hsa046110.99703358
42Pancreatic cancer_Homo sapiens_hsa052120.99490874
43Colorectal cancer_Homo sapiens_hsa052100.96428914
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94695241
45Viral carcinogenesis_Homo sapiens_hsa052030.94535609
46Legionellosis_Homo sapiens_hsa051340.91275193
47Rheumatoid arthritis_Homo sapiens_hsa053230.90478028
48VEGF signaling pathway_Homo sapiens_hsa043700.90066441
49Choline metabolism in cancer_Homo sapiens_hsa052310.89602500
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.89496513
51Apoptosis_Homo sapiens_hsa042100.89353375
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89281217
53HTLV-I infection_Homo sapiens_hsa051660.86652709
54Hepatitis C_Homo sapiens_hsa051600.85883881
55Renal cell carcinoma_Homo sapiens_hsa052110.85608724
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83172717
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80492726
58Dorso-ventral axis formation_Homo sapiens_hsa043200.79348789
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78970874
60Endometrial cancer_Homo sapiens_hsa052130.78960126
61Type II diabetes mellitus_Homo sapiens_hsa049300.78000813
62mTOR signaling pathway_Homo sapiens_hsa041500.72571694
63FoxO signaling pathway_Homo sapiens_hsa040680.72149588
64Inositol phosphate metabolism_Homo sapiens_hsa005620.70613247
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70424249
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.70297299
67African trypanosomiasis_Homo sapiens_hsa051430.63363746
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.59616390
69Other glycan degradation_Homo sapiens_hsa005110.59279309
70Prostate cancer_Homo sapiens_hsa052150.58134265
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.57433793
72Shigellosis_Homo sapiens_hsa051310.56769787
73MAPK signaling pathway_Homo sapiens_hsa040100.55800254
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54699672
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54553168
76Spliceosome_Homo sapiens_hsa030400.52672911
77GnRH signaling pathway_Homo sapiens_hsa049120.52307780
78Systemic lupus erythematosus_Homo sapiens_hsa053220.49998919
79ErbB signaling pathway_Homo sapiens_hsa040120.49691782
80Regulation of autophagy_Homo sapiens_hsa041400.49232029
81Long-term potentiation_Homo sapiens_hsa047200.48151870
82mRNA surveillance pathway_Homo sapiens_hsa030150.47389329
83Phagosome_Homo sapiens_hsa041450.46994170
84HIF-1 signaling pathway_Homo sapiens_hsa040660.46869481
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46814226
86Salmonella infection_Homo sapiens_hsa051320.44745521
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.40325237
88Insulin resistance_Homo sapiens_hsa049310.40271264
89Glioma_Homo sapiens_hsa052140.39927024
90RNA degradation_Homo sapiens_hsa030180.38916528
91Endocytosis_Homo sapiens_hsa041440.36795527
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36156082
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36060703
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35936927
95Notch signaling pathway_Homo sapiens_hsa043300.33807864
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33355091
97Pertussis_Homo sapiens_hsa051330.32821787
98Small cell lung cancer_Homo sapiens_hsa052220.31976178
99Cholinergic synapse_Homo sapiens_hsa047250.31612480
100Ras signaling pathway_Homo sapiens_hsa040140.30580001

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