INTS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.18665063
2DNA strand elongation (GO:0022616)5.13382550
3telomere maintenance via semi-conservative replication (GO:0032201)5.05725976
4DNA unwinding involved in DNA replication (GO:0006268)4.74670844
5DNA replication initiation (GO:0006270)4.70017155
6telomere maintenance via recombination (GO:0000722)4.58057580
7mitotic recombination (GO:0006312)4.46139879
8kinetochore organization (GO:0051383)4.32622860
9telomere maintenance via telomere lengthening (GO:0010833)4.21060072
10nucleotide-excision repair, DNA gap filling (GO:0006297)4.14313410
11DNA replication checkpoint (GO:0000076)4.05341493
12CENP-A containing nucleosome assembly (GO:0034080)3.92981338
13chromatin remodeling at centromere (GO:0031055)3.91849057
14IMP biosynthetic process (GO:0006188)3.90849646
15kinetochore assembly (GO:0051382)3.89173635
16DNA double-strand break processing (GO:0000729)3.86591594
17non-recombinational repair (GO:0000726)3.84082021
18double-strand break repair via nonhomologous end joining (GO:0006303)3.84082021
19ribosomal small subunit assembly (GO:0000028)3.83345774
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.81708930
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.81708930
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80145693
23protein localization to kinetochore (GO:0034501)3.75051612
24regulation of centriole replication (GO:0046599)3.70928019
25proteasome assembly (GO:0043248)3.69326310
26nuclear pore organization (GO:0006999)3.63950814
27nucleobase biosynthetic process (GO:0046112)3.62125123
28DNA ligation (GO:0006266)3.60421544
29meiotic chromosome segregation (GO:0045132)3.55130632
30telomere maintenance (GO:0000723)3.54687536
31telomere organization (GO:0032200)3.53290352
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.52767659
33DNA replication-independent nucleosome organization (GO:0034724)3.51700614
34DNA replication-independent nucleosome assembly (GO:0006336)3.51700614
35mismatch repair (GO:0006298)3.50107607
36mitochondrial RNA metabolic process (GO:0000959)3.50061543
37folic acid-containing compound biosynthetic process (GO:0009396)3.46392371
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45127465
39regulation of double-strand break repair via homologous recombination (GO:0010569)3.43765720
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43672405
41mitotic metaphase plate congression (GO:0007080)3.41819456
42nuclear pore complex assembly (GO:0051292)3.38843033
43regulation of centrosome cycle (GO:0046605)3.38336511
44purine nucleobase biosynthetic process (GO:0009113)3.37895312
45DNA catabolic process, exonucleolytic (GO:0000738)3.37577254
46ribosome assembly (GO:0042255)3.32446192
47DNA replication-dependent nucleosome assembly (GO:0006335)3.31220635
48DNA replication-dependent nucleosome organization (GO:0034723)3.31220635
49transcription-coupled nucleotide-excision repair (GO:0006283)3.31196855
50DNA geometric change (GO:0032392)3.29278507
51DNA duplex unwinding (GO:0032508)3.28970250
52amino acid activation (GO:0043038)3.27485178
53tRNA aminoacylation (GO:0043039)3.27485178
54regulation of DNA endoreduplication (GO:0032875)3.26926919
55tRNA aminoacylation for protein translation (GO:0006418)3.26284719
56spindle checkpoint (GO:0031577)3.26001307
57mitotic sister chromatid segregation (GO:0000070)3.25256974
58metaphase plate congression (GO:0051310)3.25132904
59protein localization to chromosome, centromeric region (GO:0071459)3.24706713
60attachment of spindle microtubules to kinetochore (GO:0008608)3.21529389
61DNA synthesis involved in DNA repair (GO:0000731)3.20954655
62positive regulation of chromosome segregation (GO:0051984)3.18651182
63mitotic spindle checkpoint (GO:0071174)3.17565131
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16181564
65sister chromatid segregation (GO:0000819)3.16180557
66IMP metabolic process (GO:0046040)3.15606116
67DNA topological change (GO:0006265)3.14756087
68negative regulation of chromosome segregation (GO:0051985)3.14613660
69histone exchange (GO:0043486)3.14270933
70maturation of SSU-rRNA (GO:0030490)3.14106133
71regulation of chromosome segregation (GO:0051983)3.13518097
72translesion synthesis (GO:0019985)3.13074749
73synapsis (GO:0007129)3.12360922
74mitotic nuclear envelope disassembly (GO:0007077)3.12126561
75protein K6-linked ubiquitination (GO:0085020)3.11722515
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10376089
77microtubule depolymerization (GO:0007019)3.10263451
78establishment of chromosome localization (GO:0051303)3.09552300
79chromosome segregation (GO:0007059)3.09214042
80viral mRNA export from host cell nucleus (GO:0046784)3.09102441
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07870042
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07870042
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07175654
84mitotic cell cycle (GO:0000278)3.07019913
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06182436
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06182436
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06182436
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.06182436
89negative regulation of sister chromatid segregation (GO:0033046)3.06182436
90mitotic sister chromatid cohesion (GO:0007064)3.06039923
91mitotic chromosome condensation (GO:0007076)3.04975407
92resolution of meiotic recombination intermediates (GO:0000712)3.04585325
93DNA replication (GO:0006260)3.03810057
94intra-S DNA damage checkpoint (GO:0031573)3.03242173
95positive regulation of mitotic sister chromatid separation (GO:1901970)3.01991037
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01991037
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01991037
98spliceosomal complex assembly (GO:0000245)3.01760527
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01432906
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00991946
101histone H2A acetylation (GO:0043968)3.00317976
102mitotic spindle assembly checkpoint (GO:0007094)3.00201479
103regulation of mitotic sister chromatid separation (GO:0010965)2.98430324
104regulation of mitotic sister chromatid segregation (GO:0033047)2.98430324
105regulation of sister chromatid segregation (GO:0033045)2.98430324
106spindle assembly checkpoint (GO:0071173)2.98363996
107regulation of centrosome duplication (GO:0010824)2.98253258
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.98044742
109RNA-dependent DNA replication (GO:0006278)2.97709492
110regulation of histone H3-K9 methylation (GO:0051570)2.93733685
111V(D)J recombination (GO:0033151)2.93155446
112telomere maintenance via telomerase (GO:0007004)2.92671487
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92489479
114recombinational repair (GO:0000725)2.92247972
115regulation of translational fidelity (GO:0006450)2.92220748
116somatic recombination of immunoglobulin gene segments (GO:0016447)2.92187232
117deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89929586
118DNA-dependent DNA replication (GO:0006261)2.89875203
119regulation of DNA damage checkpoint (GO:2000001)2.89390306
120base-excision repair (GO:0006284)2.88794394
121DNA strand renaturation (GO:0000733)2.88691863
122ATP-dependent chromatin remodeling (GO:0043044)2.87969043
123regulation of double-strand break repair (GO:2000779)2.87634481
124pore complex assembly (GO:0046931)2.86960767
125postreplication repair (GO:0006301)2.84958979
126DNA conformation change (GO:0071103)2.83196758
127RNA splicing, via transesterification reactions (GO:0000375)2.82444297
128negative regulation of mRNA processing (GO:0050686)2.81137082
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80745344
130mRNA splicing, via spliceosome (GO:0000398)2.80745344
131replication fork processing (GO:0031297)2.79450799
132somatic diversification of immune receptors (GO:0002200)2.78734476
133negative regulation of RNA splicing (GO:0033119)2.77759935
134ribosome biogenesis (GO:0042254)2.77375907
135nuclear envelope disassembly (GO:0051081)2.77087757
136membrane disassembly (GO:0030397)2.77087757
137positive regulation of DNA-dependent DNA replication (GO:2000105)2.76815026
138chromatin assembly or disassembly (GO:0006333)2.75736873
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74977425
140regulation of mitotic spindle checkpoint (GO:1903504)2.74977425
141DNA deamination (GO:0045006)2.73305754
142deoxyribonucleotide biosynthetic process (GO:0009263)2.72979607
143establishment of integrated proviral latency (GO:0075713)2.71835288
144nucleotide-excision repair (GO:0006289)2.71421157
145spliceosomal snRNP assembly (GO:0000387)2.71149744
146RNA export from nucleus (GO:0006405)2.70068568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44678994
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.11797622
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.59648042
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51028568
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12506672
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.82898281
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70568696
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60292253
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58818912
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58636809
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55784241
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50919667
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43150483
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40213977
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.33091419
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.25621316
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.24083232
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23107050
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.17730426
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13312744
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09548326
22FOXP3_21729870_ChIP-Seq_TREG_Human2.09229775
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07626958
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07412568
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06430350
26* E2F7_22180533_ChIP-Seq_HELA_Human11.9656931
27CIITA_25753668_ChIP-Seq_RAJI_Human1.99971170
28VDR_23849224_ChIP-Seq_CD4+_Human1.99958762
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99027965
30XRN2_22483619_ChIP-Seq_HELA_Human1.95561207
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91213708
32AR_21909140_ChIP-Seq_LNCAP_Human1.83028215
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82480603
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81845693
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79848315
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78116796
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78090661
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76286761
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.75709308
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74680128
41ELK1_19687146_ChIP-ChIP_HELA_Human1.72614844
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69886808
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69669672
44TTF2_22483619_ChIP-Seq_HELA_Human1.69326749
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65586057
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65143087
47MYC_22102868_ChIP-Seq_BL_Human1.59624573
48DCP1A_22483619_ChIP-Seq_HELA_Human1.57964115
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52657146
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52552873
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50486325
52* GABP_19822575_ChIP-Seq_HepG2_Human1.50160037
53FUS_26573619_Chip-Seq_HEK293_Human1.48734709
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.47806446
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47581032
56ZNF274_21170338_ChIP-Seq_K562_Hela1.44106435
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42209503
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39770358
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38927586
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37233719
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36893648
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.36641435
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32036687
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.31835854
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28560162
66KDM5A_27292631_Chip-Seq_BREAST_Human1.28549479
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27299320
68VDR_22108803_ChIP-Seq_LS180_Human1.26850437
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24921498
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24642480
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24121956
72* MYC_18940864_ChIP-ChIP_HL60_Human1.19761471
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16677201
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13442742
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12359228
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07557342
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07199990
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07023545
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04901169
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.04557036
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03531697
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98133309
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97228504
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94898205
85SPI1_23547873_ChIP-Seq_NB4_Human0.94615317
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93163376
87IRF1_19129219_ChIP-ChIP_H3396_Human0.93144997
88IGF1R_20145208_ChIP-Seq_DFB_Human0.91355392
89VDR_21846776_ChIP-Seq_THP-1_Human0.88030829
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86927583
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.84321867
92TFEB_21752829_ChIP-Seq_HELA_Human0.81993249
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78420945
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78008435
95STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77596544
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77295072
97TAF15_26573619_Chip-Seq_HEK293_Human0.77272116
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.76820639
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76123182
100EWS_26573619_Chip-Seq_HEK293_Human0.75224629
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75181866
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74704507
103SCL_19346495_ChIP-Seq_HPC-7_Human0.74388490
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.73764992
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73451483
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73057515
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72208981
108MYB_26560356_Chip-Seq_TH2_Human0.69786391
109MYB_26560356_Chip-Seq_TH1_Human0.68995447
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.68885588
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66769093
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66172477
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65555068
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64466928
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.64425226
116TP53_22573176_ChIP-Seq_HFKS_Human0.64389107
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.64270714
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.63951644
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.63924542
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63323553
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.61871274
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.61263264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.82437364
2MP0008057_abnormal_DNA_replication4.12156620
3MP0003111_abnormal_nucleus_morphology3.82531692
4MP0008058_abnormal_DNA_repair3.76712033
5MP0003693_abnormal_embryo_hatching3.72140081
6MP0003077_abnormal_cell_cycle3.39866386
7MP0004957_abnormal_blastocyst_morpholog2.98903032
8MP0008007_abnormal_cellular_replicative2.83546847
9MP0008877_abnormal_DNA_methylation2.83475968
10MP0002396_abnormal_hematopoietic_system2.80729961
11MP0006292_abnormal_olfactory_placode2.24342395
12MP0003786_premature_aging2.17264645
13MP0003123_paternal_imprinting2.11546849
14MP0008932_abnormal_embryonic_tissue2.09961381
15MP0003121_genomic_imprinting2.03723569
16MP0003763_abnormal_thymus_physiology1.95286717
17MP0004808_abnormal_hematopoietic_stem1.88938308
18MP0001529_abnormal_vocalization1.75307946
19MP0000350_abnormal_cell_proliferation1.73258007
20MP0000372_irregular_coat_pigmentation1.68936849
21MP0000015_abnormal_ear_pigmentation1.63522112
22MP0006035_abnormal_mitochondrial_morpho1.60828040
23MP0003787_abnormal_imprinting1.59403839
24MP0000490_abnormal_crypts_of1.58884358
25MP0002009_preneoplasia1.50263493
26MP0005409_darkened_coat_color1.41112768
27MP0001730_embryonic_growth_arrest1.40118183
28MP0005075_abnormal_melanosome_morpholog1.39893246
29MP0010307_abnormal_tumor_latency1.39119450
30MP0003315_abnormal_perineum_morphology1.37008164
31MP0005174_abnormal_tail_pigmentation1.36927127
32MP0000566_synostosis1.32380023
33MP0006054_spinal_hemorrhage1.32040612
34MP0002210_abnormal_sex_determination1.31742391
35MP0002095_abnormal_skin_pigmentation1.31493531
36MP0003806_abnormal_nucleotide_metabolis1.30297071
37MP0005380_embryogenesis_phenotype1.28127844
38MP0001672_abnormal_embryogenesis/_devel1.28127844
39MP0002398_abnormal_bone_marrow1.27588066
40MP0000703_abnormal_thymus_morphology1.27244642
41MP0002019_abnormal_tumor_incidence1.26269598
42MP0000313_abnormal_cell_death1.25733483
43MP0008995_early_reproductive_senescence1.19474281
44MP0009333_abnormal_splenocyte_physiolog1.17188638
45MP0002234_abnormal_pharynx_morphology1.16573497
46MP0003567_abnormal_fetal_cardiomyocyte1.16415849
47MP0001697_abnormal_embryo_size1.16064713
48MP0000358_abnormal_cell_content/1.14215612
49MP0002085_abnormal_embryonic_tissue1.13532969
50MP0002938_white_spotting1.12426759
51MP0001661_extended_life_span1.11812040
52MP0003984_embryonic_growth_retardation1.09938064
53MP0002160_abnormal_reproductive_system1.09542572
54MP0002132_abnormal_respiratory_system1.08911534
55MP0004197_abnormal_fetal_growth/weight/1.08799028
56MP0001346_abnormal_lacrimal_gland1.08714899
57MP0001145_abnormal_male_reproductive1.07874237
58MP0000689_abnormal_spleen_morphology1.07613195
59MP0000537_abnormal_urethra_morphology1.07197093
60MP0002102_abnormal_ear_morphology1.05653181
61MP0002722_abnormal_immune_system1.05524323
62MP0006036_abnormal_mitochondrial_physio1.05166889
63MP0006072_abnormal_retinal_apoptosis1.05066484
64MP0002088_abnormal_embryonic_growth/wei1.04939105
65MP0003890_abnormal_embryonic-extraembry1.04003388
66MP0002080_prenatal_lethality1.02126780
67MP0002075_abnormal_coat/hair_pigmentati1.00465163
68MP0001188_hyperpigmentation0.99567970
69MP0001119_abnormal_female_reproductive0.99257278
70MP0001293_anophthalmia0.98792746
71MP0000049_abnormal_middle_ear0.98415707
72MP0003943_abnormal_hepatobiliary_system0.98094546
73MP0000647_abnormal_sebaceous_gland0.97019664
74MP0005187_abnormal_penis_morphology0.96774167
75MP0000427_abnormal_hair_cycle0.96657569
76MP0003136_yellow_coat_color0.96560469
77MP0003221_abnormal_cardiomyocyte_apopto0.96402522
78MP0010030_abnormal_orbit_morphology0.96095887
79MP0001929_abnormal_gametogenesis0.96035650
80MP0002751_abnormal_autonomic_nervous0.94646787
81MP0000653_abnormal_sex_gland0.92677488
82MP0001186_pigmentation_phenotype0.91833330
83MP0002429_abnormal_blood_cell0.91350034
84MP0005394_taste/olfaction_phenotype0.90725533
85MP0005499_abnormal_olfactory_system0.90725533
86MP0001545_abnormal_hematopoietic_system0.90708358
87MP0005397_hematopoietic_system_phenotyp0.90708358
88MP0000569_abnormal_digit_pigmentation0.90662567
89MP0010352_gastrointestinal_tract_polyps0.88996156
90MP0003937_abnormal_limbs/digits/tail_de0.88394015
91MP0002084_abnormal_developmental_patter0.87980126
92MP0002086_abnormal_extraembryonic_tissu0.86629000
93MP0009697_abnormal_copulation0.85212599
94MP0000716_abnormal_immune_system0.84601713
95MP0005253_abnormal_eye_physiology0.84297908
96MP0004147_increased_porphyrin_level0.84011609
97MP0001835_abnormal_antigen_presentation0.83602679
98MP0002163_abnormal_gland_morphology0.83574652
99MP0005389_reproductive_system_phenotype0.82283106
100MP0003698_abnormal_male_reproductive0.82051086
101MP0001764_abnormal_homeostasis0.81789028
102MP0008789_abnormal_olfactory_epithelium0.81735250
103MP0005671_abnormal_response_to0.81450655
104MP0001800_abnormal_humoral_immune0.81054389
105MP0005379_endocrine/exocrine_gland_phen0.80557355
106MP0003941_abnormal_skin_development0.78929428
107MP0005367_renal/urinary_system_phenotyp0.78385965
108MP0000516_abnormal_urinary_system0.78385965
109MP0002111_abnormal_tail_morphology0.77869430
110MP0001286_abnormal_eye_development0.77768289
111MP0005645_abnormal_hypothalamus_physiol0.76510212
112MP0002249_abnormal_larynx_morphology0.75698539
113MP0002420_abnormal_adaptive_immunity0.74795141
114MP0003718_maternal_effect0.74003226
115MP0009053_abnormal_anal_canal0.73712711
116MP0002877_abnormal_melanocyte_morpholog0.72765527
117MP0005646_abnormal_pituitary_gland0.72714512
118MP0000465_gastrointestinal_hemorrhage0.72566958
119MP0002697_abnormal_eye_size0.72278846
120MP0000858_altered_metastatic_potential0.72144865
121MP0005220_abnormal_exocrine_pancreas0.72028764
122MP0001819_abnormal_immune_cell0.72022056
123MP0002166_altered_tumor_susceptibility0.71807286
124MP0001915_intracranial_hemorrhage0.71395461
125MP0009672_abnormal_birth_weight0.71199211
126MP0005395_other_phenotype0.71031762
127MP0009703_decreased_birth_body0.69759148
128MP0002233_abnormal_nose_morphology0.68346665
129MP0003186_abnormal_redox_activity0.68036409
130MP0003950_abnormal_plasma_membrane0.67116534
131MP0000631_abnormal_neuroendocrine_gland0.66258134
132MP0005384_cellular_phenotype0.64936449
133MP0003699_abnormal_female_reproductive0.64181632
134MP0005266_abnormal_metabolism0.63076310
135MP0010234_abnormal_vibrissa_follicle0.62741788
136MP0005391_vision/eye_phenotype0.61833925
137MP0004233_abnormal_muscle_weight0.60561579
138MP0001919_abnormal_reproductive_system0.60485817

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.25333222
2Chromsome breakage (HP:0040012)5.22257473
3Birth length less than 3rd percentile (HP:0003561)3.88384981
4Meckel diverticulum (HP:0002245)3.55233427
5Abnormality of chromosome stability (HP:0003220)3.53594652
6Reticulocytopenia (HP:0001896)3.53076133
7Abnormality of the preputium (HP:0100587)3.41579772
8Abnormality of the ileum (HP:0001549)3.39906453
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.39194845
10Ectopic kidney (HP:0000086)3.34085144
11Duplicated collecting system (HP:0000081)3.11575953
1211 pairs of ribs (HP:0000878)3.07642090
13Cortical dysplasia (HP:0002539)3.03285185
14Patellar aplasia (HP:0006443)3.00742710
15Abnormal lung lobation (HP:0002101)2.97503810
16Abnormality of the renal collecting system (HP:0004742)2.88028092
17Small intestinal stenosis (HP:0012848)2.83020834
18Duodenal stenosis (HP:0100867)2.83020834
19Aplasia/Hypoplasia of the patella (HP:0006498)2.78995391
20Bone marrow hypocellularity (HP:0005528)2.77486443
21Myelodysplasia (HP:0002863)2.74437079
22Breast hypoplasia (HP:0003187)2.72647783
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71892774
24Abnormality of alanine metabolism (HP:0010916)2.71892774
25Hyperalaninemia (HP:0003348)2.71892774
26Nephroblastoma (Wilms tumor) (HP:0002667)2.69301799
27Absent thumb (HP:0009777)2.64339980
28Medulloblastoma (HP:0002885)2.63298618
29Abnormality of glycolysis (HP:0004366)2.61232603
30Clubbing of toes (HP:0100760)2.58774543
31Increased serum pyruvate (HP:0003542)2.58537592
32Colon cancer (HP:0003003)2.55979722
33Embryonal renal neoplasm (HP:0011794)2.53359077
34Abnormality of the carotid arteries (HP:0005344)2.53325325
35Abnormal number of erythroid precursors (HP:0012131)2.53016873
36Impulsivity (HP:0100710)2.47362052
37Abnormality of DNA repair (HP:0003254)2.45786788
38Premature graying of hair (HP:0002216)2.43685692
39Abnormality of the fingertips (HP:0001211)2.35228900
40Glioma (HP:0009733)2.32676345
41Selective tooth agenesis (HP:0001592)2.32540527
42Abnormality of cells of the erythroid lineage (HP:0012130)2.31788093
43Sloping forehead (HP:0000340)2.31622358
44Abnormality of the duodenum (HP:0002246)2.29485291
45Aplastic anemia (HP:0001915)2.28876728
46Short 4th metacarpal (HP:0010044)2.28429164
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28429164
48Abnormal number of incisors (HP:0011064)2.27325004
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27021539
50Abnormality of the astrocytes (HP:0100707)2.24909181
51Astrocytoma (HP:0009592)2.24909181
52Agnosia (HP:0010524)2.21648140
53Triphalangeal thumb (HP:0001199)2.21091827
54Lymphoma (HP:0002665)2.16883101
55Volvulus (HP:0002580)2.13785133
56Increased serum lactate (HP:0002151)2.13311602
57Increased CSF lactate (HP:0002490)2.13224493
58Hyperglycinemia (HP:0002154)2.12262934
59Supernumerary spleens (HP:0009799)2.10598036
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.04605334
61Short thumb (HP:0009778)2.03091778
62Tracheoesophageal fistula (HP:0002575)2.01634999
63Degeneration of anterior horn cells (HP:0002398)2.01447955
64Abnormality of the anterior horn cell (HP:0006802)2.01447955
65Acute encephalopathy (HP:0006846)2.01299805
66Small hand (HP:0200055)1.99631723
67Limb hypertonia (HP:0002509)1.97976643
68Asplenia (HP:0001746)1.97660564
69Oral leukoplakia (HP:0002745)1.97026565
70Absent radius (HP:0003974)1.96954735
71Intestinal fistula (HP:0100819)1.95511497
72IgM deficiency (HP:0002850)1.93523956
73Abnormality of the labia minora (HP:0012880)1.93497390
74Cutaneous melanoma (HP:0012056)1.93202000
75Rough bone trabeculation (HP:0100670)1.93075901
76Increased nuchal translucency (HP:0010880)1.92960021
77Abnormality of serum amino acid levels (HP:0003112)1.92022085
78Abnormality of methionine metabolism (HP:0010901)1.92001091
79Progressive inability to walk (HP:0002505)1.91762348
80Acute necrotizing encephalopathy (HP:0006965)1.91427580
81Cellular immunodeficiency (HP:0005374)1.90582365
82Cerebral edema (HP:0002181)1.90335244
83Neoplasm of the pancreas (HP:0002894)1.88299973
84Increased hepatocellular lipid droplets (HP:0006565)1.87862098
85Absent epiphyses (HP:0010577)1.86544161
86Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86544161
87Horseshoe kidney (HP:0000085)1.86264760
88Spinal cord lesions (HP:0100561)1.85110371
89Syringomyelia (HP:0003396)1.85110371
90Abnormality of the intervertebral disk (HP:0005108)1.84863162
91Rectovaginal fistula (HP:0000143)1.84194281
92Rectal fistula (HP:0100590)1.84194281
93Renal cortical cysts (HP:0000803)1.83856605
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.83369721
95Carpal bone hypoplasia (HP:0001498)1.80610830
96Duplication of thumb phalanx (HP:0009942)1.80421938
97Aplasia involving forearm bones (HP:0009822)1.79572509
98Absent forearm bone (HP:0003953)1.79572509
99Abnormality of serine family amino acid metabolism (HP:0010894)1.79527480
100Abnormality of glycine metabolism (HP:0010895)1.79527480
101Arteriovenous malformation (HP:0100026)1.79223799
102Neoplasm of the adrenal gland (HP:0100631)1.79162250
103Ependymoma (HP:0002888)1.79143355
104Rhabdomyosarcoma (HP:0002859)1.78822742
105Lipid accumulation in hepatocytes (HP:0006561)1.78428128
106Thrombocytosis (HP:0001894)1.78009164
107Deep philtrum (HP:0002002)1.76737312
108Abnormality of the incisor (HP:0000676)1.74916179
109Abnormal mitochondria in muscle tissue (HP:0008316)1.74089977
110Amaurosis fugax (HP:0100576)1.72574447
111Missing ribs (HP:0000921)1.72067677
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72014509
113Hyperglycinuria (HP:0003108)1.71113616
114Preaxial hand polydactyly (HP:0001177)1.71065533
115Postnatal microcephaly (HP:0005484)1.70727917
116Squamous cell carcinoma (HP:0002860)1.70234808
117Methylmalonic acidemia (HP:0002912)1.70154339
118Long clavicles (HP:0000890)1.69731429
119Intestinal atresia (HP:0011100)1.69314747
120Neoplasm of the adrenal cortex (HP:0100641)1.68483577
121Rib fusion (HP:0000902)1.68240998
122Partial agenesis of the corpus callosum (HP:0001338)1.67343329
123Pancreatic islet-cell hyperplasia (HP:0004510)1.66807887
124Pancreatic cysts (HP:0001737)1.66696388
125Secondary amenorrhea (HP:0000869)1.66585803
126Multiple enchondromatosis (HP:0005701)1.66094387
127Type I transferrin isoform profile (HP:0003642)1.65743351
128Choanal atresia (HP:0000453)1.65734673
129Astigmatism (HP:0000483)1.64490586
130Abnormality of chromosome segregation (HP:0002916)1.62343117
131Abnormal hair whorl (HP:0010721)1.62209532
132Optic nerve coloboma (HP:0000588)1.62144401
133Cafe-au-lait spot (HP:0000957)1.61239580
134Overlapping toe (HP:0001845)1.60968773
135Tubulointerstitial nephritis (HP:0001970)1.60820551
136Oligodactyly (hands) (HP:0001180)1.60517930
137Pallor (HP:0000980)1.60370464
138Deviation of the thumb (HP:0009603)1.59929813
139Progressive macrocephaly (HP:0004481)1.59711345
140Atresia of the external auditory canal (HP:0000413)1.59136688
141Abnormal protein glycosylation (HP:0012346)1.58865951
142Abnormal glycosylation (HP:0012345)1.58865951
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58865951
144Abnormal protein N-linked glycosylation (HP:0012347)1.58865951
145Panhypogammaglobulinemia (HP:0003139)1.58378413
146Lactic acidosis (HP:0003128)1.58101171
147Mitochondrial inheritance (HP:0001427)1.57807074
148B lymphocytopenia (HP:0010976)1.55406657
149Abnormality of B cell number (HP:0010975)1.55406657
150T lymphocytopenia (HP:0005403)1.55190776
151Severe combined immunodeficiency (HP:0004430)1.54946144
152Agammaglobulinemia (HP:0004432)1.54056427
153Pancytopenia (HP:0001876)1.53221880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.11317892
2WEE13.21804685
3SRPK13.06856721
4MKNK13.03174329
5BUB12.79912718
6MKNK22.54754063
7TRIM282.47114899
8PBK2.44884277
9STK162.41143572
10CLK12.31691187
11ZAK2.18208607
12VRK12.17610919
13TLK12.14653423
14ATR2.09225413
15PASK2.03308841
16TSSK61.97801358
17CDK81.96672008
18EIF2AK11.94011536
19ACVR1B1.86739979
20NEK21.86382017
21CCNB11.85395189
22PRPF4B1.83354410
23BRD41.79000063
24VRK21.76318700
25MST41.69415894
26PLK41.68508204
27CDK71.67579146
28CDK121.66028852
29PLK31.62386384
30FRK1.62150224
31PLK11.58686933
32PNCK1.57159887
33YES11.53346461
34BRSK21.51599226
35BCR1.49992653
36TTK1.46642874
37MAP4K11.43103199
38STK41.40669404
39EIF2AK31.39565707
40AURKB1.35645702
41EIF2AK21.35486909
42BMPR1B1.33550983
43CDK41.27656077
44DYRK31.25599186
45RPS6KB21.24405320
46PDK21.22367466
47PIM11.21560773
48CHEK21.20607751
49CHEK11.19737961
50TAF11.16434107
51TEC1.16383033
52TXK1.15108294
53WNK31.12771652
54BCKDK1.08833885
55RPS6KA41.08763591
56CSNK1G31.07586403
57ATM1.05522728
58CSNK1G11.05427781
59MAP3K141.04630576
60AKT31.03886079
61CSNK1A1L1.01847839
62SCYL21.01028957
63BRSK10.95428193
64BTK0.93227022
65ERBB40.93031297
66TGFBR10.89588306
67MAP4K20.86503535
68IRAK40.85424938
69CDK20.85357696
70SGK20.82259684
71CASK0.80775572
72CSNK1G20.77991958
73NEK10.75878635
74PLK20.74991449
75WNK40.74298153
76SIK30.74261787
77CDK10.71733964
78NME20.71482915
79AURKA0.71167499
80NEK60.71078247
81NUAK10.68965677
82EEF2K0.67967290
83TIE10.66817089
84MELK0.66799647
85NME10.66514223
86STK240.64707406
87MAP3K80.63078378
88BLK0.62883033
89CSNK2A10.62182737
90STK100.61902386
91RPS6KA50.61227577
92ERBB30.60942987
93NEK90.60942509
94MAP3K40.59692253
95CSNK2A20.58421947
96MAP3K100.58010565
97MST1R0.57850368
98ALK0.57201687
99RPS6KL10.56183009
100RPS6KC10.56183009
101RPS6KB10.56152942
102INSRR0.55800439
103RPS6KA60.54893411
104CHUK0.53696723
105STK390.53610357
106CDK30.52119331
107GRK10.51904115
108PRKCI0.50806244
109NLK0.48881583
110KIT0.48714537
111LATS10.45587465
112CSF1R0.45146984
113LYN0.44157903
114STK30.43222252
115JAK30.43019997
116MAP2K70.41967044
117CAMKK20.41787072
118MAPK140.40492529
119AKT10.40475543
120CDK90.40382903
121PRKDC0.39578904
122BRAF0.39505695
123RAF10.39080820
124SGK30.37874705
125ADRBK20.37112266
126SYK0.36988935
127CSNK1E0.34759651
128MAPK130.34540183
129IKBKB0.34379353
130STK38L0.33241440
131CDK60.32483616
132PIM20.32343696
133FLT30.32251887
134ZAP700.31831343
135KDR0.31591720
136DAPK10.29319210
137OXSR10.27581862
138MAPKAPK50.27489662
139KSR10.26864714
140DYRK20.23846365

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24825079
2Mismatch repair_Homo sapiens_hsa034304.58329273
3Homologous recombination_Homo sapiens_hsa034403.55795904
4Base excision repair_Homo sapiens_hsa034103.51725769
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24353448
6Spliceosome_Homo sapiens_hsa030403.15704249
7Nucleotide excision repair_Homo sapiens_hsa034203.11428521
8Non-homologous end-joining_Homo sapiens_hsa034503.06429370
9Fanconi anemia pathway_Homo sapiens_hsa034602.93612016
10Cell cycle_Homo sapiens_hsa041102.76568586
11RNA polymerase_Homo sapiens_hsa030202.75868464
12RNA transport_Homo sapiens_hsa030132.48571916
13One carbon pool by folate_Homo sapiens_hsa006702.42623258
14Ribosome_Homo sapiens_hsa030102.34649287
15Pyrimidine metabolism_Homo sapiens_hsa002402.23272257
16Basal transcription factors_Homo sapiens_hsa030222.17031404
17Proteasome_Homo sapiens_hsa030501.99450117
18RNA degradation_Homo sapiens_hsa030181.97386517
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95820432
20mRNA surveillance pathway_Homo sapiens_hsa030151.88167069
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83405994
22Propanoate metabolism_Homo sapiens_hsa006401.60492099
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.58803393
24Primary immunodeficiency_Homo sapiens_hsa053401.53922981
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53137129
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47552220
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31727073
28p53 signaling pathway_Homo sapiens_hsa041151.30195366
29Purine metabolism_Homo sapiens_hsa002301.29102341
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22413602
31Pyruvate metabolism_Homo sapiens_hsa006201.21078707
32Systemic lupus erythematosus_Homo sapiens_hsa053221.19316727
33Herpes simplex infection_Homo sapiens_hsa051681.18672963
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17843773
35Epstein-Barr virus infection_Homo sapiens_hsa051691.10153540
36Biosynthesis of amino acids_Homo sapiens_hsa012301.09786335
37Fatty acid elongation_Homo sapiens_hsa000621.06350382
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00293725
39Parkinsons disease_Homo sapiens_hsa050120.98070026
40Carbon metabolism_Homo sapiens_hsa012000.94533378
41Oxidative phosphorylation_Homo sapiens_hsa001900.93706487
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93378283
43HTLV-I infection_Homo sapiens_hsa051660.92037961
44Antigen processing and presentation_Homo sapiens_hsa046120.91550475
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90601711
46Steroid biosynthesis_Homo sapiens_hsa001000.88389148
47Viral carcinogenesis_Homo sapiens_hsa052030.88226055
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87655466
49Butanoate metabolism_Homo sapiens_hsa006500.86818111
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.85637112
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81393152
52Measles_Homo sapiens_hsa051620.78936826
53Protein export_Homo sapiens_hsa030600.71106212
54MicroRNAs in cancer_Homo sapiens_hsa052060.69626995
55Basal cell carcinoma_Homo sapiens_hsa052170.68348861
56Hematopoietic cell lineage_Homo sapiens_hsa046400.65110185
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.64734983
58Sulfur metabolism_Homo sapiens_hsa009200.64140694
59Peroxisome_Homo sapiens_hsa041460.63641228
60Sulfur relay system_Homo sapiens_hsa041220.62264091
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61115957
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60989499
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60389134
64Small cell lung cancer_Homo sapiens_hsa052220.59359951
65Thyroid cancer_Homo sapiens_hsa052160.58375270
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57136128
67Folate biosynthesis_Homo sapiens_hsa007900.57077155
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56613320
69Fatty acid metabolism_Homo sapiens_hsa012120.56564056
70Metabolic pathways_Homo sapiens_hsa011000.56434184
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55707895
72Oocyte meiosis_Homo sapiens_hsa041140.54810608
73Hepatitis B_Homo sapiens_hsa051610.54214274
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53940569
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52830227
76Colorectal cancer_Homo sapiens_hsa052100.52726991
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52310574
78Alcoholism_Homo sapiens_hsa050340.49457405
79B cell receptor signaling pathway_Homo sapiens_hsa046620.47940847
80Selenocompound metabolism_Homo sapiens_hsa004500.46784698
81Notch signaling pathway_Homo sapiens_hsa043300.46276633
82Influenza A_Homo sapiens_hsa051640.46191867
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46009230
84Glutathione metabolism_Homo sapiens_hsa004800.42838750
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.42548882
86Chronic myeloid leukemia_Homo sapiens_hsa052200.42096932
87T cell receptor signaling pathway_Homo sapiens_hsa046600.41830457
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41479179
89Apoptosis_Homo sapiens_hsa042100.40309043
90N-Glycan biosynthesis_Homo sapiens_hsa005100.40234425
91Legionellosis_Homo sapiens_hsa051340.39331768
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39276609
93Prostate cancer_Homo sapiens_hsa052150.39219596
94Autoimmune thyroid disease_Homo sapiens_hsa053200.38393782
95Nitrogen metabolism_Homo sapiens_hsa009100.37904593
96Wnt signaling pathway_Homo sapiens_hsa043100.37233882
97Caffeine metabolism_Homo sapiens_hsa002320.37011927
98Alzheimers disease_Homo sapiens_hsa050100.36434853
99TGF-beta signaling pathway_Homo sapiens_hsa043500.36342386
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35789832
101Pathways in cancer_Homo sapiens_hsa052000.35366931
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34203696
103Allograft rejection_Homo sapiens_hsa053300.33484631
104Arachidonic acid metabolism_Homo sapiens_hsa005900.32771274
105Acute myeloid leukemia_Homo sapiens_hsa052210.32572234
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32557177
107Graft-versus-host disease_Homo sapiens_hsa053320.31400328
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.31017957
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30563533
110Hippo signaling pathway_Homo sapiens_hsa043900.30182702
111Non-small cell lung cancer_Homo sapiens_hsa052230.29619822
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.29356524
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.29218701
114Shigellosis_Homo sapiens_hsa051310.27354996
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26461921
116Regulation of autophagy_Homo sapiens_hsa041400.25357515
117Tryptophan metabolism_Homo sapiens_hsa003800.25132966
118Lysine degradation_Homo sapiens_hsa003100.23829465
119FoxO signaling pathway_Homo sapiens_hsa040680.22470392
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22265222
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21139079
122Asthma_Homo sapiens_hsa053100.20520327
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20364961
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19916812
125Leishmaniasis_Homo sapiens_hsa051400.19912542
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19873431
127Arginine and proline metabolism_Homo sapiens_hsa003300.19671540
128Viral myocarditis_Homo sapiens_hsa054160.19650959
129Melanoma_Homo sapiens_hsa052180.19524088
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19456849
131Huntingtons disease_Homo sapiens_hsa050160.18191416
132Pancreatic cancer_Homo sapiens_hsa052120.18094235
133Hedgehog signaling pathway_Homo sapiens_hsa043400.17155068
134Pentose phosphate pathway_Homo sapiens_hsa000300.16978999
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16877995
136beta-Alanine metabolism_Homo sapiens_hsa004100.15380312
137Phototransduction_Homo sapiens_hsa047440.15043449
138Vitamin B6 metabolism_Homo sapiens_hsa007500.14797313
139Endometrial cancer_Homo sapiens_hsa052130.14754959
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.13060167
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12702883
142Ether lipid metabolism_Homo sapiens_hsa005650.09240821
143Fatty acid degradation_Homo sapiens_hsa000710.08968154
144Arginine biosynthesis_Homo sapiens_hsa002200.08076480
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.07939499
146Taste transduction_Homo sapiens_hsa047420.07184650
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06176692
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04900035

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