INTS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.81564471
2DNA strand elongation (GO:0022616)4.62164685
3telomere maintenance via semi-conservative replication (GO:0032201)4.61016053
4ribosomal small subunit assembly (GO:0000028)4.53759820
5DNA unwinding involved in DNA replication (GO:0006268)4.47987589
6DNA replication initiation (GO:0006270)4.35436844
7telomere maintenance via recombination (GO:0000722)4.14061090
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.01023046
9mitotic recombination (GO:0006312)3.98969654
10maturation of SSU-rRNA (GO:0030490)3.91506938
11DNA replication checkpoint (GO:0000076)3.89370569
12DNA deamination (GO:0045006)3.76504649
13formation of translation preinitiation complex (GO:0001731)3.70006577
14nucleobase biosynthetic process (GO:0046112)3.67191170
15telomere maintenance via telomere lengthening (GO:0010833)3.66534800
16mitotic metaphase plate congression (GO:0007080)3.57490475
17protein localization to kinetochore (GO:0034501)3.57452729
18nuclear pore complex assembly (GO:0051292)3.52685933
19nucleotide-excision repair, DNA gap filling (GO:0006297)3.52056477
20IMP biosynthetic process (GO:0006188)3.50403849
21DNA ligation (GO:0006266)3.49168778
22establishment of integrated proviral latency (GO:0075713)3.47776792
23purine nucleobase biosynthetic process (GO:0009113)3.43357134
24viral transcription (GO:0019083)3.42568680
25DNA damage response, detection of DNA damage (GO:0042769)3.42124289
26mitotic chromosome condensation (GO:0007076)3.41955105
27mitotic nuclear envelope disassembly (GO:0007077)3.41472552
28metaphase plate congression (GO:0051310)3.40252783
29meiotic chromosome segregation (GO:0045132)3.37093615
30translational termination (GO:0006415)3.35270922
31CENP-A containing nucleosome assembly (GO:0034080)3.35225877
32establishment of chromosome localization (GO:0051303)3.27587461
33regulation of spindle organization (GO:0090224)3.25339269
34chromatin remodeling at centromere (GO:0031055)3.25144116
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24785550
36regulation of mitotic spindle checkpoint (GO:1903504)3.24785550
37ribosomal small subunit biogenesis (GO:0042274)3.22625859
38kinetochore organization (GO:0051383)3.18869768
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.18537024
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18537024
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16503115
42IMP metabolic process (GO:0046040)3.14661083
43translational elongation (GO:0006414)3.14252143
44protein localization to chromosome, centromeric region (GO:0071459)3.12819810
45non-recombinational repair (GO:0000726)3.10870314
46double-strand break repair via nonhomologous end joining (GO:0006303)3.10870314
47ribosome biogenesis (GO:0042254)3.10496483
48mismatch repair (GO:0006298)3.09568125
49ribonucleoprotein complex biogenesis (GO:0022613)3.07993098
50membrane disassembly (GO:0030397)3.06730672
51nuclear envelope disassembly (GO:0051081)3.06730672
52DNA replication-independent nucleosome organization (GO:0034724)3.04276323
53DNA replication-independent nucleosome assembly (GO:0006336)3.04276323
54DNA duplex unwinding (GO:0032508)3.01763370
55DNA geometric change (GO:0032392)3.01075926
56pore complex assembly (GO:0046931)3.01004178
57ribosomal large subunit biogenesis (GO:0042273)3.00885574
58DNA catabolic process, exonucleolytic (GO:0000738)3.00566689
59folic acid-containing compound biosynthetic process (GO:0009396)2.99586951
60proteasome assembly (GO:0043248)2.99549264
61histone H2A acetylation (GO:0043968)2.99451744
62telomere organization (GO:0032200)2.98264518
63translational initiation (GO:0006413)2.98220607
64telomere maintenance (GO:0000723)2.97676176
65DNA replication-dependent nucleosome assembly (GO:0006335)2.97265900
66DNA replication-dependent nucleosome organization (GO:0034723)2.97265900
67mitochondrial RNA metabolic process (GO:0000959)2.97133762
68DNA double-strand break processing (GO:0000729)2.95779321
69DNA topological change (GO:0006265)2.95166882
70regulation of mitotic spindle organization (GO:0060236)2.94350697
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92593272
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91950533
73kinetochore assembly (GO:0051382)2.91687717
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91010798
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91010798
76base-excision repair (GO:0006284)2.90917217
77attachment of spindle microtubules to kinetochore (GO:0008608)2.89290562
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88851088
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88851088
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88851088
81transcription-coupled nucleotide-excision repair (GO:0006283)2.88621226
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88282417
83mitotic sister chromatid segregation (GO:0000070)2.88191362
84viral mRNA export from host cell nucleus (GO:0046784)2.85221651
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.84307079
86rRNA processing (GO:0006364)2.84205718
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84044817
88signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83052919
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.83052919
90mitotic spindle checkpoint (GO:0071174)2.81983206
91ribosome assembly (GO:0042255)2.81907501
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81131615
93pseudouridine synthesis (GO:0001522)2.79986876
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79710294
95negative regulation of ligase activity (GO:0051352)2.79255598
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79255598
97chromosome segregation (GO:0007059)2.79094324
98establishment of viral latency (GO:0019043)2.78917477
99regulation of spindle checkpoint (GO:0090231)2.78809450
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78391165
101cotranslational protein targeting to membrane (GO:0006613)2.78045570
102synapsis (GO:0007129)2.77463624
103rRNA metabolic process (GO:0016072)2.77054573
104positive regulation of chromosome segregation (GO:0051984)2.76449708
105protein targeting to ER (GO:0045047)2.75790831
106regulation of translation in response to stress (GO:0043555)2.74021780
107spindle checkpoint (GO:0031577)2.73436375
108maturation of 5.8S rRNA (GO:0000460)2.71885439
109spliceosomal snRNP assembly (GO:0000387)2.71766983
110negative regulation of chromosome segregation (GO:0051985)2.71739484
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.71018265
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71018265
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71018265
114negative regulation of sister chromatid segregation (GO:0033046)2.71018265
115G1/S transition of mitotic cell cycle (GO:0000082)2.70980826
116cell cycle G1/S phase transition (GO:0044843)2.70980826
117mitotic spindle assembly checkpoint (GO:0007094)2.70858088
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69709746
119tRNA aminoacylation for protein translation (GO:0006418)2.69681281
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68227344
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67045118
122histone exchange (GO:0043486)2.67036447
123sister chromatid segregation (GO:0000819)2.66470316
124nuclear pore organization (GO:0006999)2.66104324
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65927225
126positive regulation of gamma-delta T cell activation (GO:0046645)2.65266784
127postreplication repair (GO:0006301)2.65189258
128viral life cycle (GO:0019058)2.65186988
129positive regulation of B cell differentiation (GO:0045579)2.64181533
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63972623
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63801552
132cellular protein complex disassembly (GO:0043624)2.63677802
133spindle assembly checkpoint (GO:0071173)2.62033842
134RNA splicing, via transesterification reactions (GO:0000375)2.61947675
135mRNA splicing, via spliceosome (GO:0000398)2.61938448
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61938448
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.61858424
138positive regulation of ligase activity (GO:0051351)2.61456336
139amino acid activation (GO:0043038)2.61453623
140tRNA aminoacylation (GO:0043039)2.61453623
141piRNA metabolic process (GO:0034587)2.59171198
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58126635
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58126635
144transcription from mitochondrial promoter (GO:0006390)2.57109041
145positive regulation of histone H3-K4 methylation (GO:0051571)2.52671919
146regulation of chromosome segregation (GO:0051983)2.51386593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77860845
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.83190411
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73288572
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57658073
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44149554
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11857125
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.80578629
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74718032
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59057172
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.54938829
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53165168
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51085493
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51041368
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45962731
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.43523325
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34041137
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26600223
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17625951
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.15457575
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15277547
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14025273
22* XRN2_22483619_ChIP-Seq_HELA_Human2.13937998
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13449012
24VDR_23849224_ChIP-Seq_CD4+_Human2.10782821
25MYC_22102868_ChIP-Seq_BL_Human2.05114249
26FOXP3_21729870_ChIP-Seq_TREG_Human1.98484883
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91951595
28AR_21909140_ChIP-Seq_LNCAP_Human1.90108080
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.86345661
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85479820
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85023017
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81911151
33CIITA_25753668_ChIP-Seq_RAJI_Human1.79521547
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.73989482
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73489111
36GABP_19822575_ChIP-Seq_HepG2_Human1.71597555
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66674437
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65422311
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64818007
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62556885
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62008373
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61937908
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61153758
44* TTF2_22483619_ChIP-Seq_HELA_Human1.60699682
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57533545
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57056202
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55101652
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54878619
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54492948
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53422154
51* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53222191
52ELK1_19687146_ChIP-ChIP_HELA_Human1.49724164
53VDR_21846776_ChIP-Seq_THP-1_Human1.46520571
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43496919
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.41053164
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.40685405
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40165156
58SPI1_23547873_ChIP-Seq_NB4_Human1.37223482
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35493881
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35020921
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34963677
62* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32315318
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32303205
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31660772
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31394390
66GATA1_22025678_ChIP-Seq_K562_Human1.27265332
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.26137864
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.24534097
69KDM5A_27292631_Chip-Seq_BREAST_Human1.23937580
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21094851
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.20579151
72SCL_19346495_ChIP-Seq_HPC-7_Human1.16690291
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15588696
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13791097
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12204415
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09994904
77* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07758867
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06946871
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.06886712
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05968121
81TFEB_21752829_ChIP-Seq_HELA_Human1.05585946
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04696788
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04454521
84* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00275169
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99466905
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98942730
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98297290
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96840234
89MYB_26560356_Chip-Seq_TH2_Human0.96506736
90ZNF274_21170338_ChIP-Seq_K562_Hela0.96085975
91UTX_26944678_Chip-Seq_JUKART_Human0.95624863
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94361933
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93562740
94MYB_26560356_Chip-Seq_TH1_Human0.90688147
95* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90305030
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89927381
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89717929
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89603072
99MYC_18940864_ChIP-ChIP_HL60_Human0.89456464
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89144573
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88961373
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88174149
103MAF_26560356_Chip-Seq_TH1_Human0.87622740
104RUNX1_22412390_ChIP-Seq_EML_Mouse0.86707253
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86485124
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84846740
107BP1_19119308_ChIP-ChIP_Hs578T_Human0.84322624
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82994909
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81220110
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81196335
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80958673
112* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78226930
113NCOR1_26117541_ChIP-Seq_K562_Human0.74523632
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73268871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66450790
2MP0010094_abnormal_chromosome_stability4.23764680
3MP0003111_abnormal_nucleus_morphology3.89565948
4MP0003077_abnormal_cell_cycle3.63092905
5MP0004957_abnormal_blastocyst_morpholog3.59254006
6MP0008057_abnormal_DNA_replication3.58739071
7MP0002396_abnormal_hematopoietic_system3.36064143
8MP0008058_abnormal_DNA_repair2.99966839
9MP0000372_irregular_coat_pigmentation2.76427386
10MP0008007_abnormal_cellular_replicative2.57420080
11MP0000015_abnormal_ear_pigmentation2.27721087
12MP0008932_abnormal_embryonic_tissue2.15917908
13MP0004808_abnormal_hematopoietic_stem2.15041518
14MP0003172_abnormal_lysosome_physiology2.09804931
15MP0003763_abnormal_thymus_physiology2.05115850
16MP0000490_abnormal_crypts_of2.04253030
17MP0002102_abnormal_ear_morphology2.02584482
18MP0005671_abnormal_response_to1.91624464
19MP0006035_abnormal_mitochondrial_morpho1.86212723
20MP0009333_abnormal_splenocyte_physiolog1.85440596
21MP0000350_abnormal_cell_proliferation1.84929088
22MP0001730_embryonic_growth_arrest1.83111432
23MP0001545_abnormal_hematopoietic_system1.78367204
24MP0005397_hematopoietic_system_phenotyp1.78367204
25MP0002398_abnormal_bone_marrow1.78275316
26MP0002138_abnormal_hepatobiliary_system1.76423270
27MP0010352_gastrointestinal_tract_polyps1.75489959
28MP0001835_abnormal_antigen_presentation1.74215832
29MP0006054_spinal_hemorrhage1.67354577
30MP0006036_abnormal_mitochondrial_physio1.66063042
31MP0008877_abnormal_DNA_methylation1.65933626
32MP0008995_early_reproductive_senescence1.63369704
33MP0000685_abnormal_immune_system1.61626076
34MP0002722_abnormal_immune_system1.60463028
35MP0003786_premature_aging1.58552187
36MP0000465_gastrointestinal_hemorrhage1.55095415
37MP0000689_abnormal_spleen_morphology1.54955784
38MP0000703_abnormal_thymus_morphology1.53926931
39MP0002019_abnormal_tumor_incidence1.49412723
40MP0003221_abnormal_cardiomyocyte_apopto1.47624759
41MP0000313_abnormal_cell_death1.47066517
42MP0010307_abnormal_tumor_latency1.45067626
43MP0001800_abnormal_humoral_immune1.44970556
44MP0003656_abnormal_erythrocyte_physiolo1.42875632
45MP0003806_abnormal_nucleotide_metabolis1.41454551
46MP0002429_abnormal_blood_cell1.40629248
47MP0005380_embryogenesis_phenotype1.38053811
48MP0001672_abnormal_embryogenesis/_devel1.38053811
49MP0000716_abnormal_immune_system1.37852117
50MP0001697_abnormal_embryo_size1.36565595
51MP0002420_abnormal_adaptive_immunity1.34585772
52MP0002452_abnormal_antigen_presenting1.34505691
53MP0001819_abnormal_immune_cell1.33244626
54MP0005084_abnormal_gallbladder_morpholo1.31526505
55MP0001853_heart_inflammation1.28154409
56MP0003436_decreased_susceptibility_to1.27240194
57MP0003984_embryonic_growth_retardation1.26771097
58MP0002080_prenatal_lethality1.25929847
59MP0002088_abnormal_embryonic_growth/wei1.23183899
60MP0005464_abnormal_platelet_physiology1.22288580
61MP0003303_peritoneal_inflammation1.20563810
62MP0002405_respiratory_system_inflammati1.18986278
63MP0002723_abnormal_immune_serum1.18787319
64MP0002132_abnormal_respiratory_system1.15884860
65MP0005075_abnormal_melanosome_morpholog1.14355219
66MP0010155_abnormal_intestine_physiology1.14108661
67MP0008789_abnormal_olfactory_epithelium1.13668086
68MP0003567_abnormal_fetal_cardiomyocyte1.13144474
69MP0003718_maternal_effect1.10829440
70MP0005025_abnormal_response_to1.10706559
71MP0005451_abnormal_body_composition1.09777750
72MP0002085_abnormal_embryonic_tissue1.09013465
73MP0009785_altered_susceptibility_to1.08964432
74MP0003123_paternal_imprinting1.08402330
75MP0002086_abnormal_extraembryonic_tissu1.08084416
76MP0005000_abnormal_immune_tolerance1.07776366
77MP0003315_abnormal_perineum_morphology1.06609348
78MP0009278_abnormal_bone_marrow1.01865435
79MP0008260_abnormal_autophagy0.97632220
80MP0004147_increased_porphyrin_level0.96690227
81MP0010030_abnormal_orbit_morphology0.96239594
82MP0002419_abnormal_innate_immunity0.96065420
83MP0005076_abnormal_cell_differentiation0.94391281
84MP0001529_abnormal_vocalization0.93711155
85MP0002084_abnormal_developmental_patter0.92876199
86MP0001915_intracranial_hemorrhage0.92270471
87MP0000858_altered_metastatic_potential0.92228902
88MP0002751_abnormal_autonomic_nervous0.91394235
89MP0002210_abnormal_sex_determination0.91320814
90MP0001293_anophthalmia0.90773141
91MP0001790_abnormal_immune_system0.89521209
92MP0005387_immune_system_phenotype0.89521209
93MP0002148_abnormal_hypersensitivity_rea0.89378384
94MP0005023_abnormal_wound_healing0.89373911
95MP0001119_abnormal_female_reproductive0.88573510
96MP0005499_abnormal_olfactory_system0.88531532
97MP0005394_taste/olfaction_phenotype0.88531532
98MP0004264_abnormal_extraembryonic_tissu0.86519859
99MP0000371_diluted_coat_color0.86451276
100MP0002269_muscular_atrophy0.86197301
101MP0005395_other_phenotype0.85055840
102MP0004197_abnormal_fetal_growth/weight/0.83895066
103MP0005621_abnormal_cell_physiology0.83881237
104MP0003186_abnormal_redox_activity0.82904995
105MP0002166_altered_tumor_susceptibility0.81336986
106MP0005266_abnormal_metabolism0.80583801
107MP0006292_abnormal_olfactory_placode0.80444975
108MP0005384_cellular_phenotype0.78882111
109MP0004381_abnormal_hair_follicle0.78880698
110MP0001845_abnormal_inflammatory_respons0.78799054
111MP0003566_abnormal_cell_adhesion0.77035287
112MP0001145_abnormal_male_reproductive0.76175918
113MP0002006_tumorigenesis0.74571638
114MP0001873_stomach_inflammation0.74073996
115MP0000477_abnormal_intestine_morphology0.73727119
116MP0003866_abnormal_defecation0.73508547
117MP0002234_abnormal_pharynx_morphology0.72297515
118MP0005058_abnormal_lysosome_morphology0.72192031
119MP0003121_genomic_imprinting0.72021776
120MP0003699_abnormal_female_reproductive0.71698003
121MP0005174_abnormal_tail_pigmentation0.71372235
122MP0001929_abnormal_gametogenesis0.71092513
123MP0002095_abnormal_skin_pigmentation0.70265944
124MP0000358_abnormal_cell_content/0.69354896
125MP0000653_abnormal_sex_gland0.65553943
126MP0000343_altered_response_to0.64009813
127MP0009697_abnormal_copulation0.63454363
128MP0003943_abnormal_hepatobiliary_system0.62968103
129MP0008469_abnormal_protein_level0.62383600

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.40746219
2Reticulocytopenia (HP:0001896)4.26670074
3Colon cancer (HP:0003003)3.78588529
4Aplastic anemia (HP:0001915)3.78289910
5Chromsome breakage (HP:0040012)3.76033230
6Agnosia (HP:0010524)3.58557691
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46169485
8Abnormality of cells of the erythroid lineage (HP:0012130)3.35664113
9Abnormal mitochondria in muscle tissue (HP:0008316)3.32699723
10Acute necrotizing encephalopathy (HP:0006965)3.29227858
11Oral leukoplakia (HP:0002745)3.28315337
12Abnormal number of erythroid precursors (HP:0012131)3.22050909
13Cholecystitis (HP:0001082)3.18707961
14Abnormal gallbladder physiology (HP:0012438)3.18707961
15Breast hypoplasia (HP:0003187)3.04798980
16Hepatocellular necrosis (HP:0001404)3.01976852
17Petechiae (HP:0000967)3.01961244
18Medulloblastoma (HP:0002885)2.99182151
19IgM deficiency (HP:0002850)2.96716349
20Acute encephalopathy (HP:0006846)2.93882603
21Patellar aplasia (HP:0006443)2.92934318
22Abnormal protein N-linked glycosylation (HP:0012347)2.92535142
23Abnormal protein glycosylation (HP:0012346)2.92535142
24Abnormal glycosylation (HP:0012345)2.92535142
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92535142
26Degeneration of anterior horn cells (HP:0002398)2.88296307
27Abnormality of the anterior horn cell (HP:0006802)2.88296307
28Chronic otitis media (HP:0000389)2.82378084
29Abnormality of the preputium (HP:0100587)2.82013910
30Abnormality of chromosome stability (HP:0003220)2.80771272
31Hepatic necrosis (HP:0002605)2.79169733
32Mitochondrial inheritance (HP:0001427)2.76598964
33Increased CSF lactate (HP:0002490)2.75969170
34Meckel diverticulum (HP:0002245)2.72737561
35Selective tooth agenesis (HP:0001592)2.72175353
36Abnormality of the ileum (HP:0001549)2.70671769
37Ependymoma (HP:0002888)2.69253260
38Thrombocytosis (HP:0001894)2.68330084
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.67925511
40Albinism (HP:0001022)2.65912404
41Aplasia/Hypoplasia of the patella (HP:0006498)2.64445041
42Myelodysplasia (HP:0002863)2.63558051
4311 pairs of ribs (HP:0000878)2.62419312
44Ectopic kidney (HP:0000086)2.61157612
45Rough bone trabeculation (HP:0100670)2.59393977
46Progressive macrocephaly (HP:0004481)2.57761396
47Absent thumb (HP:0009777)2.56852205
48Bone marrow hypocellularity (HP:0005528)2.51615539
49Abnormality of the labia minora (HP:0012880)2.50185614
50Carpal bone hypoplasia (HP:0001498)2.47804717
51Duodenal stenosis (HP:0100867)2.42376888
52Small intestinal stenosis (HP:0012848)2.42376888
53Lymphoma (HP:0002665)2.41675348
54Panhypogammaglobulinemia (HP:0003139)2.40440538
55Pallor (HP:0000980)2.37558353
56Increased intramyocellular lipid droplets (HP:0012240)2.33565473
57Amaurosis fugax (HP:0100576)2.32822703
58Increased serum lactate (HP:0002151)2.29752885
59Macrocytic anemia (HP:0001972)2.29517131
60Basal cell carcinoma (HP:0002671)2.27985190
61Premature graying of hair (HP:0002216)2.25091043
62Increased muscle lipid content (HP:0009058)2.23380233
63Neoplasm of the adrenal cortex (HP:0100641)2.23281027
64Neoplasm of the adrenal gland (HP:0100631)2.23125573
65Recurrent abscess formation (HP:0002722)2.22672285
66Rhabdomyosarcoma (HP:0002859)2.21223978
67Optic nerve coloboma (HP:0000588)2.20700176
68Methylmalonic acidemia (HP:0002912)2.20686988
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19668370
70Clubbing of toes (HP:0100760)2.19644273
71Volvulus (HP:0002580)2.19102371
72Cerebral hypomyelination (HP:0006808)2.15468277
73Lipid accumulation in hepatocytes (HP:0006561)2.13832377
74Abnormal number of incisors (HP:0011064)2.13595386
75Exercise intolerance (HP:0003546)2.11269338
76Cerebral edema (HP:0002181)2.11157070
77Recurrent viral infections (HP:0004429)2.10860736
78Respiratory failure (HP:0002878)2.10476391
79Neoplasm of the pancreas (HP:0002894)2.05888806
80Abnormality of the prostate (HP:0008775)2.05590700
81Lactic acidosis (HP:0003128)2.05562253
82Sloping forehead (HP:0000340)2.04905931
83Microvesicular hepatic steatosis (HP:0001414)2.03304893
84Severe combined immunodeficiency (HP:0004430)2.01360402
85Tracheoesophageal fistula (HP:0002575)1.99015745
86Multiple enchondromatosis (HP:0005701)1.98930746
87Trismus (HP:0000211)1.97172248
88Progressive muscle weakness (HP:0003323)1.96712249
89Horseshoe kidney (HP:0000085)1.96272292
90Pancytopenia (HP:0001876)1.95267112
91Pulmonary fibrosis (HP:0002206)1.95263214
92Abnormality of the duodenum (HP:0002246)1.94867150
93Increased hepatocellular lipid droplets (HP:0006565)1.94831980
94Elevated erythrocyte sedimentation rate (HP:0003565)1.94380136
95Nausea (HP:0002018)1.94226460
96Abnormal trabecular bone morphology (HP:0100671)1.93353231
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91694816
98Cellular immunodeficiency (HP:0005374)1.90120051
99Cellulitis (HP:0100658)1.89716910
100Chronic obstructive pulmonary disease (HP:0006510)1.89673259
101Obstructive lung disease (HP:0006536)1.89673259
102Pustule (HP:0200039)1.87914776
103Abnormality of DNA repair (HP:0003254)1.87489254
104Triphalangeal thumb (HP:0001199)1.87470173
105Short middle phalanx of the 5th finger (HP:0004220)1.86451302
106Abnormal lung lobation (HP:0002101)1.86368662
107Agammaglobulinemia (HP:0004432)1.86275073
108Abnormality of T cells (HP:0002843)1.86253743
109Acute myeloid leukemia (HP:0004808)1.84739143
110Slender long bone (HP:0003100)1.84084434
111CNS hypomyelination (HP:0003429)1.83995383
112Type I transferrin isoform profile (HP:0003642)1.83479337
113Absent radius (HP:0003974)1.82683978
114Abnormality of T cell physiology (HP:0011840)1.82477541
115Poor head control (HP:0002421)1.81519001
116Neoplasm of the oral cavity (HP:0100649)1.80222642
117Recurrent bacterial skin infections (HP:0005406)1.80023283
118Impulsivity (HP:0100710)1.78143954
119Abnormality of glycolysis (HP:0004366)1.77517513
120Abnormality of cells of the lymphoid lineage (HP:0012140)1.77509236
121Methylmalonic aciduria (HP:0012120)1.77378532
122Spastic paraparesis (HP:0002313)1.77312965
123Increased serum pyruvate (HP:0003542)1.77308524
124Acute lymphatic leukemia (HP:0006721)1.76949190
125Leukopenia (HP:0001882)1.76892062
126Muscle fiber atrophy (HP:0100295)1.76747165
127Combined immunodeficiency (HP:0005387)1.76579716
128Poikiloderma (HP:0001029)1.75522591
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75122596
130Dicarboxylic aciduria (HP:0003215)1.75122596
131Lymphopenia (HP:0001888)1.75116677
132Recurrent bronchitis (HP:0002837)1.75008612
133Neoplasm of the colon (HP:0100273)1.74263897
134Duplicated collecting system (HP:0000081)1.74261563
135Cleft eyelid (HP:0000625)1.74099733
136Type 2 muscle fiber atrophy (HP:0003554)1.74075447
137Reduced antithrombin III activity (HP:0001976)1.73596959
138Shoulder girdle muscle weakness (HP:0003547)1.73110111
139IgG deficiency (HP:0004315)1.73087412
140Hypokinesia (HP:0002375)1.72349737
141Long eyelashes (HP:0000527)1.72349582
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.72297096
143Abnormality of reticulocytes (HP:0004312)1.71500137
144Sparse eyelashes (HP:0000653)1.71276332
145Generalized aminoaciduria (HP:0002909)1.70929933
146Cortical dysplasia (HP:0002539)1.70658112
147Granulocytopenia (HP:0001913)1.70296662
148Premature ovarian failure (HP:0008209)1.69153253
149B lymphocytopenia (HP:0010976)1.68826653
150Hypertensive crisis (HP:0100735)1.67860100
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.66539032
152Cholelithiasis (HP:0001081)1.66505910
153Respiratory difficulties (HP:0002880)1.65697564
154Cutis marmorata (HP:0000965)1.65519907
155Broad alveolar ridges (HP:0000187)1.63824479
156CNS demyelination (HP:0007305)1.63773851
157Iris hypopigmentation (HP:0007730)1.62969619
158Emotional lability (HP:0000712)1.62391199
159Hypergonadotropic hypogonadism (HP:0000815)1.62343264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.70904210
2VRK23.66088779
3MAP4K23.60307401
4CDC73.58440649
5WEE13.50750021
6EIF2AK13.02425009
7MAP4K12.57461709
8NEK22.16424401
9STK102.08547318
10STK162.01946532
11NME22.01923729
12ACVR1B1.98416565
13TSSK61.98109115
14BRSK21.91242693
15RIPK41.91096830
16RPS6KB21.89322878
17PASK1.78114465
18PIM21.76257551
19PLK41.75991973
20PLK11.71227075
21TAOK31.69188646
22BTK1.68292913
23CCNB11.67269486
24ATR1.66814801
25TTK1.63782935
26CDK71.63302485
27NEK11.63096165
28TESK21.62612424
29RPS6KA41.61912036
30EEF2K1.57818451
31MAP2K31.55827900
32TEC1.52737677
33MKNK11.50657895
34EIF2AK31.49586387
35KIT1.47228078
36CDK121.46602824
37TGFBR11.45061632
38MST41.44958220
39VRK11.44137504
40TRIM281.41156674
41AURKB1.40894813
42SRPK11.40642573
43PDK21.36504990
44DYRK31.33119689
45PBK1.32180354
46RAF11.30068316
47MAP3K81.29487362
48BRSK11.28058044
49PIM11.23760833
50MAP3K101.20529082
51KDR1.17466282
52TXK1.12237506
53CDK41.11410911
54ZAP701.10178226
55IRAK41.08813965
56PLK31.05608994
57LRRK21.03989930
58SMG11.03658725
59CDK191.02899188
60CHEK20.97236619
61CLK10.96983084
62CHEK10.92439952
63TAF10.91562297
64AURKA0.91224532
65JAK30.90298840
66CSNK1G30.87288986
67RPS6KA50.87093593
68TNK20.86606633
69BLK0.85836356
70TYK20.84388116
71CSF1R0.84318892
72SYK0.83978209
73STK40.81308133
74CDK80.81074951
75PAK40.80833786
76CSNK1G20.77809441
77NME10.77745116
78BRD40.77679246
79MAP3K110.76153177
80ERN10.75102583
81CDK30.74937029
82CDK90.74636587
83ITK0.74211499
84MAPKAPK50.73349920
85MKNK20.70501221
86CSNK1G10.68481709
87TESK10.68035847
88ATM0.67761203
89FLT30.66865965
90TLK10.66588450
91CDK20.66067572
92BMPR20.65955829
93CSNK1A1L0.64112256
94LYN0.62809368
95MAPK110.61454224
96MAP3K140.60474748
97TAOK20.59990575
98SIK30.58549255
99SCYL20.58240580
100NUAK10.57274358
101EIF2AK20.56921411
102RPS6KA60.56838163
103DAPK10.56691117
104PAK10.56583636
105BRAF0.56445711
106RPS6KL10.56264826
107RPS6KC10.56264826
108MATK0.55802127
109MAP3K60.54878437
110LCK0.54161642
111CSNK2A10.53853919
112IKBKB0.52017886
113ZAK0.50900744
114CSNK2A20.49641904
115PLK20.46380714
116CDK10.44317864
117FGR0.42904512
118CHUK0.42885047
119GRK60.42605971
120MAPKAPK20.42384785
121CDK60.42371156
122MAP2K60.42075901
123MAP3K50.40645270
124ILK0.40644605
125MELK0.37336114
126PRKCQ0.36336384
127WNK30.35665558
128MAP3K40.35118372
129ARAF0.35029381
130BCKDK0.33991813
131MARK30.32657772
132IKBKE0.32524983

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05124594
2Mismatch repair_Homo sapiens_hsa034304.18416509
3Base excision repair_Homo sapiens_hsa034103.54575284
4Ribosome_Homo sapiens_hsa030103.16200568
5Spliceosome_Homo sapiens_hsa030403.00763206
6RNA polymerase_Homo sapiens_hsa030202.98084946
7Homologous recombination_Homo sapiens_hsa034402.96364488
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93152794
9Proteasome_Homo sapiens_hsa030502.90163858
10Nucleotide excision repair_Homo sapiens_hsa034202.64042705
11Cell cycle_Homo sapiens_hsa041102.56787877
12RNA transport_Homo sapiens_hsa030132.54470168
13One carbon pool by folate_Homo sapiens_hsa006702.39090779
14Pyrimidine metabolism_Homo sapiens_hsa002402.37476706
15Fanconi anemia pathway_Homo sapiens_hsa034602.18270911
16Non-homologous end-joining_Homo sapiens_hsa034502.12153642
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01439630
18Basal transcription factors_Homo sapiens_hsa030221.88897373
19RNA degradation_Homo sapiens_hsa030181.84616152
20Primary immunodeficiency_Homo sapiens_hsa053401.60875876
21p53 signaling pathway_Homo sapiens_hsa041151.59668369
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55482312
23mRNA surveillance pathway_Homo sapiens_hsa030151.43710645
24Oxidative phosphorylation_Homo sapiens_hsa001901.40778293
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38749794
26Parkinsons disease_Homo sapiens_hsa050121.36740007
27Graft-versus-host disease_Homo sapiens_hsa053321.31559301
28Epstein-Barr virus infection_Homo sapiens_hsa051691.29112597
29Autoimmune thyroid disease_Homo sapiens_hsa053201.29024151
30Purine metabolism_Homo sapiens_hsa002301.23440590
31Antigen processing and presentation_Homo sapiens_hsa046121.21643035
32Herpes simplex infection_Homo sapiens_hsa051681.19825460
33Pentose phosphate pathway_Homo sapiens_hsa000301.02975071
34Type I diabetes mellitus_Homo sapiens_hsa049400.98791677
35Fatty acid elongation_Homo sapiens_hsa000620.97032896
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95421105
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.94102494
38Shigellosis_Homo sapiens_hsa051310.93885202
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.92313804
40Propanoate metabolism_Homo sapiens_hsa006400.90384157
41Huntingtons disease_Homo sapiens_hsa050160.89938828
42Measles_Homo sapiens_hsa051620.88487935
43HTLV-I infection_Homo sapiens_hsa051660.87665395
44Viral carcinogenesis_Homo sapiens_hsa052030.86287364
45Legionellosis_Homo sapiens_hsa051340.85783639
46Rheumatoid arthritis_Homo sapiens_hsa053230.83103223
47Apoptosis_Homo sapiens_hsa042100.75642386
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75188370
49Collecting duct acid secretion_Homo sapiens_hsa049660.73954895
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.73630854
51Leishmaniasis_Homo sapiens_hsa051400.71076828
52Hematopoietic cell lineage_Homo sapiens_hsa046400.70747108
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.69469757
54Folate biosynthesis_Homo sapiens_hsa007900.69271129
55Biosynthesis of amino acids_Homo sapiens_hsa012300.68593235
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68377199
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67692297
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.66462115
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66398801
60B cell receptor signaling pathway_Homo sapiens_hsa046620.62668140
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61548237
62Hepatitis B_Homo sapiens_hsa051610.61348327
63Oocyte meiosis_Homo sapiens_hsa041140.59753706
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59017431
65Acute myeloid leukemia_Homo sapiens_hsa052210.58704182
66Influenza A_Homo sapiens_hsa051640.57191357
67Notch signaling pathway_Homo sapiens_hsa043300.55191772
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54638262
69Small cell lung cancer_Homo sapiens_hsa052220.54582618
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54284648
71Pyruvate metabolism_Homo sapiens_hsa006200.54251151
72Selenocompound metabolism_Homo sapiens_hsa004500.53581027
73Protein export_Homo sapiens_hsa030600.52865402
74Thyroid cancer_Homo sapiens_hsa052160.52569325
75N-Glycan biosynthesis_Homo sapiens_hsa005100.52410073
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52297910
77Systemic lupus erythematosus_Homo sapiens_hsa053220.52201556
78Viral myocarditis_Homo sapiens_hsa054160.50446322
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50305043
80MicroRNAs in cancer_Homo sapiens_hsa052060.50156565
81Chronic myeloid leukemia_Homo sapiens_hsa052200.49936990
82Sulfur metabolism_Homo sapiens_hsa009200.48020271
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47090342
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45373752
85Steroid biosynthesis_Homo sapiens_hsa001000.45168332
86Other glycan degradation_Homo sapiens_hsa005110.44770533
87Colorectal cancer_Homo sapiens_hsa052100.44616803
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43975250
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43831398
90Lysosome_Homo sapiens_hsa041420.43042806
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41461505
92Regulation of autophagy_Homo sapiens_hsa041400.41435543
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41061030
94Sulfur relay system_Homo sapiens_hsa041220.40098789
95Metabolic pathways_Homo sapiens_hsa011000.39228073
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.38860506
97Glutathione metabolism_Homo sapiens_hsa004800.38317994
98Vitamin B6 metabolism_Homo sapiens_hsa007500.37864557
99Phagosome_Homo sapiens_hsa041450.37637876
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.35964867
101Lysine degradation_Homo sapiens_hsa003100.35705897
102Carbon metabolism_Homo sapiens_hsa012000.34982121
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.34339746
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34035433
105Vibrio cholerae infection_Homo sapiens_hsa051100.33888561
106T cell receptor signaling pathway_Homo sapiens_hsa046600.32989207
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32980083
108Peroxisome_Homo sapiens_hsa041460.32788047
109Tuberculosis_Homo sapiens_hsa051520.32127389
110Staphylococcus aureus infection_Homo sapiens_hsa051500.31890275
111Toxoplasmosis_Homo sapiens_hsa051450.30057172
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29892933
113Asthma_Homo sapiens_hsa053100.29298250
114Platelet activation_Homo sapiens_hsa046110.29055303
115Pancreatic cancer_Homo sapiens_hsa052120.28895552
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28702255
117Alzheimers disease_Homo sapiens_hsa050100.27891941
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27491349
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26513296
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25995883
121Pathways in cancer_Homo sapiens_hsa052000.25927722
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25422837
123Osteoclast differentiation_Homo sapiens_hsa043800.25328741
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25176845
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24860183
126Basal cell carcinoma_Homo sapiens_hsa052170.24128659
127Galactose metabolism_Homo sapiens_hsa000520.23432038
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23363911
129HIF-1 signaling pathway_Homo sapiens_hsa040660.22401846
130Allograft rejection_Homo sapiens_hsa053300.21934357
131Malaria_Homo sapiens_hsa051440.21645375

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