INTU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.50064801
2meiotic chromosome segregation (GO:0045132)6.04247871
3piRNA metabolic process (GO:0034587)5.76879549
4metaphase plate congression (GO:0051310)5.37537876
5protein K6-linked ubiquitination (GO:0085020)5.22832659
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.21550952
7regulation of meiosis I (GO:0060631)5.15493058
8regulation of exit from mitosis (GO:0007096)5.08450126
9regulation of meiosis (GO:0040020)4.95647961
10cilium or flagellum-dependent cell motility (GO:0001539)4.87956222
11negative regulation of hormone biosynthetic process (GO:0032353)4.82906475
12negative regulation of hormone metabolic process (GO:0032351)4.82906475
13histone H2A monoubiquitination (GO:0035518)4.76257702
14oocyte maturation (GO:0001556)4.76179831
15establishment of chromosome localization (GO:0051303)4.72784758
16female gamete generation (GO:0007292)4.66079617
17female gonad development (GO:0008585)4.65850921
18negative regulation of meiosis (GO:0045835)4.64017065
19male meiosis (GO:0007140)4.56153395
20regulation of sister chromatid cohesion (GO:0007063)4.45920461
21attachment of spindle microtubules to kinetochore (GO:0008608)4.36788312
22DNA damage response, signal transduction resulting in transcription (GO:0042772)4.35651406
23DNA damage induced protein phosphorylation (GO:0006975)4.32699223
24mitotic chromosome condensation (GO:0007076)4.31364607
25sphingosine metabolic process (GO:0006670)4.29990190
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.25826317
27DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.25156769
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22161082
29indole-containing compound catabolic process (GO:0042436)4.20219710
30indolalkylamine catabolic process (GO:0046218)4.20219710
31tryptophan catabolic process (GO:0006569)4.20219710
32maturation of 5.8S rRNA (GO:0000460)4.19494312
33regulation of female gonad development (GO:2000194)4.09503291
34monoubiquitinated protein deubiquitination (GO:0035520)4.05970420
35regulation of meiotic cell cycle (GO:0051445)4.02267003
36indolalkylamine metabolic process (GO:0006586)4.01081044
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.01046599
38DNA methylation involved in gamete generation (GO:0043046)4.00854850
39regulation of pigment cell differentiation (GO:0050932)3.99692571
40regulation of retinoic acid receptor signaling pathway (GO:0048385)3.96259387
41histone H2A ubiquitination (GO:0033522)3.94433190
42kynurenine metabolic process (GO:0070189)3.93721627
43positive regulation of developmental pigmentation (GO:0048087)3.91142609
44neural tube formation (GO:0001841)3.87546084
45meiotic cell cycle (GO:0051321)3.85383835
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.83559458
47diol metabolic process (GO:0034311)3.82404288
48microtubule depolymerization (GO:0007019)3.82330841
49regulation of transcription from RNA polymerase I promoter (GO:0006356)3.77435344
50regulation of hippo signaling (GO:0035330)3.76270157
51cilium movement (GO:0003341)3.75213462
52signal peptide processing (GO:0006465)3.75196270
53male meiosis I (GO:0007141)3.75050501
54resolution of meiotic recombination intermediates (GO:0000712)3.69736196
55reciprocal DNA recombination (GO:0035825)3.69500162
56reciprocal meiotic recombination (GO:0007131)3.69500162
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.67892102
58negative regulation of translation, ncRNA-mediated (GO:0040033)3.67892102
59regulation of translation, ncRNA-mediated (GO:0045974)3.67892102
60kinetochore assembly (GO:0051382)3.67513508
61CENP-A containing nucleosome assembly (GO:0034080)3.66520591
62histone demethylation (GO:0016577)3.65017922
63histone lysine demethylation (GO:0070076)3.64793174
64meiosis I (GO:0007127)3.59647157
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.59454344
66chromatin remodeling at centromere (GO:0031055)3.57425481
67sister chromatid cohesion (GO:0007062)3.56945369
68histone exchange (GO:0043486)3.55834647
69chromosome segregation (GO:0007059)3.51037392
70tryptophan metabolic process (GO:0006568)3.50759214
71establishment of protein localization to Golgi (GO:0072600)3.46242567
72regulation of gene silencing by RNA (GO:0060966)3.42027595
73regulation of posttranscriptional gene silencing (GO:0060147)3.42027595
74regulation of gene silencing by miRNA (GO:0060964)3.42027595
75behavioral response to nicotine (GO:0035095)3.39409200
76meiotic cell cycle process (GO:1903046)3.38111450
77protein K48-linked deubiquitination (GO:0071108)3.36801716
78gamma-aminobutyric acid transport (GO:0015812)3.33876929
79photoreceptor cell maintenance (GO:0045494)3.33062290
80sphingoid metabolic process (GO:0046519)3.32462577
81epithelial cilium movement (GO:0003351)3.32369920
82myoblast migration (GO:0051451)3.32289283
83synaptonemal complex assembly (GO:0007130)3.31312116
84positive regulation of meiosis (GO:0045836)3.31262192
85negative regulation of smooth muscle cell differentiation (GO:0051151)3.31255514
86regulation of telomere maintenance via telomerase (GO:0032210)3.29890164
87DNA synthesis involved in DNA repair (GO:0000731)3.29598634
88mitotic sister chromatid cohesion (GO:0007064)3.29370404
89mismatch repair (GO:0006298)3.28414586
90detection of light stimulus involved in sensory perception (GO:0050962)3.28178037
91detection of light stimulus involved in visual perception (GO:0050908)3.28178037
92protein demethylation (GO:0006482)3.28168901
93protein dealkylation (GO:0008214)3.28168901
94regulation of establishment of cell polarity (GO:2000114)3.27656620
95positive regulation of megakaryocyte differentiation (GO:0045654)3.26285703
96regulation of glucocorticoid metabolic process (GO:0031943)3.25541419
97replication fork processing (GO:0031297)3.25284995
98regulation of spindle organization (GO:0090224)3.24486640
99protein K11-linked deubiquitination (GO:0035871)3.23849710
100microtubule nucleation (GO:0007020)3.21021822
101regulation of sarcomere organization (GO:0060297)3.20626742
102DNA replication-independent nucleosome assembly (GO:0006336)3.19558355
103DNA replication-independent nucleosome organization (GO:0034724)3.19558355
104mitotic sister chromatid segregation (GO:0000070)3.17910614
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.17507883
106positive regulation of meiotic cell cycle (GO:0051446)3.15432150
107meiotic nuclear division (GO:0007126)3.14057965
108cellular response to sterol (GO:0036315)3.14040162
109indole-containing compound metabolic process (GO:0042430)3.12097544
110negative regulation of DNA-dependent DNA replication (GO:2000104)3.11483402
111kinetochore organization (GO:0051383)3.10802942
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10583205
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10583205
114positive regulation of mitotic sister chromatid separation (GO:1901970)3.10583205
115protein localization to chromosome (GO:0034502)3.10304334
116positive regulation of chromosome segregation (GO:0051984)3.10221926
117notochord development (GO:0030903)3.09862081
118regulation of histone H3-K27 methylation (GO:0061085)3.07846389
119reflex (GO:0060004)3.05751142
120spindle checkpoint (GO:0031577)3.04711756
121L-fucose catabolic process (GO:0042355)3.04612213
122fucose catabolic process (GO:0019317)3.04612213
123L-fucose metabolic process (GO:0042354)3.04612213
124serotonin metabolic process (GO:0042428)3.03465043
125glycerophospholipid catabolic process (GO:0046475)3.03341622
126presynaptic membrane assembly (GO:0097105)3.01821475
127protein localization to chromosome, centromeric region (GO:0071459)3.01590988
128snRNA transcription (GO:0009301)3.01528109
129synaptonemal complex organization (GO:0070193)2.99503018
130axoneme assembly (GO:0035082)2.99386973
131microtubule severing (GO:0051013)2.99332872
132regulation of chromosome segregation (GO:0051983)2.96982274
133central nervous system neuron axonogenesis (GO:0021955)2.96946147
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.95676155
135negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.95088881
136negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95088881
137protein localization to kinetochore (GO:0034501)2.94891603
138microtubule polymerization or depolymerization (GO:0031109)2.94509980
139DNA alkylation (GO:0006305)2.94245262
140DNA methylation (GO:0006306)2.94245262
141interkinetic nuclear migration (GO:0022027)2.93361916
142regulation of transforming growth factor beta2 production (GO:0032909)2.93328075
143* cilium organization (GO:0044782)2.90231141
144behavioral response to ethanol (GO:0048149)2.88903720
145negative regulation of protein localization to cell surface (GO:2000009)2.87859815
146axon ensheathment in central nervous system (GO:0032291)2.87188597
147central nervous system myelination (GO:0022010)2.87188597
148lipid translocation (GO:0034204)2.84825093
149phospholipid translocation (GO:0045332)2.84825093
150* cilium assembly (GO:0042384)2.84772167
151cilium morphogenesis (GO:0060271)2.84493356
152central nervous system projection neuron axonogenesis (GO:0021952)2.79243026
153negative regulation of sodium ion transport (GO:0010766)2.79131673
154membrane depolarization during action potential (GO:0086010)2.79013646
155primary amino compound metabolic process (GO:1901160)2.77008748
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76816149
157sulfation (GO:0051923)2.76481222
158retinal cone cell development (GO:0046549)2.74213965
159nonmotile primary cilium assembly (GO:0035058)2.73308505
160detection of mechanical stimulus involved in sensory perception (GO:0050974)2.72616401
161oxidative demethylation (GO:0070989)2.71068136
162inner ear receptor stereocilium organization (GO:0060122)2.70838027
163thyroid hormone metabolic process (GO:0042403)2.70469174
164presynaptic membrane organization (GO:0097090)2.65940746
165axonemal dynein complex assembly (GO:0070286)2.65906088
166negative regulation of systemic arterial blood pressure (GO:0003085)2.65253826
167regulation of establishment or maintenance of cell polarity (GO:0032878)2.64595445
168cytoplasmic mRNA processing body assembly (GO:0033962)2.63797610
169protein K63-linked deubiquitination (GO:0070536)2.62639825
170postsynaptic membrane organization (GO:0001941)2.62174175
171microtubule anchoring (GO:0034453)2.57665242
172benzene-containing compound metabolic process (GO:0042537)2.57582891
173negative regulation of astrocyte differentiation (GO:0048712)2.55801954
174regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54761899
175tachykinin receptor signaling pathway (GO:0007217)2.54537439
176transmission of nerve impulse (GO:0019226)2.54392216
177spinal cord motor neuron differentiation (GO:0021522)2.53342204
178positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.53265898
179centriole replication (GO:0007099)2.53006289
180intraciliary transport (GO:0042073)2.52941107
181neuronal action potential (GO:0019228)2.52673560
182cellular ketone body metabolic process (GO:0046950)2.52298117
183flavonoid metabolic process (GO:0009812)2.51360369
184nucleus localization (GO:0051647)2.50527288
185membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48488342
186startle response (GO:0001964)2.47235979
187* cellular component assembly involved in morphogenesis (GO:0010927)2.46459689
188regulation of collateral sprouting (GO:0048670)2.46378956
189cardiovascular system development (GO:0072358)2.46229741
190response to pheromone (GO:0019236)2.45936195
191prenylation (GO:0097354)2.43896536
192protein prenylation (GO:0018342)2.43896536
193amine catabolic process (GO:0009310)2.41531560
194cellular biogenic amine catabolic process (GO:0042402)2.41531560
195regulation of cilium movement (GO:0003352)2.40581197
196auditory receptor cell stereocilium organization (GO:0060088)2.39199359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.63669160
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.56761339
3E2F7_22180533_ChIP-Seq_HELA_Human3.44007117
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.26279965
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.08646118
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97526548
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95021942
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93492812
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89663400
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87695212
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.64082778
12ZNF274_21170338_ChIP-Seq_K562_Hela2.51266001
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47634854
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.38750165
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37821419
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16458964
17IGF1R_20145208_ChIP-Seq_DFB_Human2.15464998
18GBX2_23144817_ChIP-Seq_PC3_Human2.15148153
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12403428
20SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97835285
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97126416
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95856111
23NANOG_18555785_Chip-Seq_ESCs_Mouse1.89975269
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.89647532
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88236021
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88148963
27LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85547002
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.81661553
29ER_23166858_ChIP-Seq_MCF-7_Human1.80491099
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80328622
31FUS_26573619_Chip-Seq_HEK293_Human1.79384328
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78925559
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75457075
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73516933
35AR_21909140_ChIP-Seq_LNCAP_Human1.69364549
36RNF2_27304074_Chip-Seq_NSC_Mouse1.68309645
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67665837
38* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66882837
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66676638
40* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65871801
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64901866
42BCAT_22108803_ChIP-Seq_LS180_Human1.64197801
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.64050872
44TP53_16413492_ChIP-PET_HCT116_Human1.62928079
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61441419
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.58784542
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57729251
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57729251
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.55975576
50CBP_20019798_ChIP-Seq_JUKART_Human1.53145834
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53145834
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51433569
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.51364767
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51329593
55* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51194488
56* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50446432
57STAT3_23295773_ChIP-Seq_U87_Human1.50223737
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47683731
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44749337
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44519560
61RUNX1_26923725_Chip-Seq_HPCs_Mouse1.44392961
62DROSHA_22980978_ChIP-Seq_HELA_Human1.44073404
63EWS_26573619_Chip-Seq_HEK293_Human1.44026767
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.42087126
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41869855
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.41188985
67P53_22387025_ChIP-Seq_ESCs_Mouse1.40403641
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39989334
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.39258200
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.36772652
71TBL1_22424771_ChIP-Seq_293T_Human1.36761520
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36659555
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.36497945
74ZFX_18555785_Chip-Seq_ESCs_Mouse1.36044432
75RUNX2_22187159_ChIP-Seq_PCA_Human1.35190048
76* TCF4_22108803_ChIP-Seq_LS180_Human1.35089103
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34517182
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.34493377
79AHR_22903824_ChIP-Seq_MCF-7_Human1.33449675
80SMAD4_21799915_ChIP-Seq_A2780_Human1.32554622
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32459653
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.32274681
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.32210427
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31352523
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31269691
86KLF4_18555785_Chip-Seq_ESCs_Mouse1.28384792
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.26478341
88REST_21632747_ChIP-Seq_MESCs_Mouse1.26093836
89VDR_22108803_ChIP-Seq_LS180_Human1.25473056
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.25329266
91* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24007735
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23229493
93* PRDM14_20953172_ChIP-Seq_ESCs_Human1.22880035
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22716791
95* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21548745
96TAF15_26573619_Chip-Seq_HEK293_Human1.21362392
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20858220
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20828725
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20786203
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.20528521
101* STAT1_17558387_ChIP-Seq_HELA_Human1.20293994
102NFYA_21822215_ChIP-Seq_K562_Human1.19403718
103* P300_19829295_ChIP-Seq_ESCs_Human1.18280287
104ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17559873
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.16673169
106RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16344059
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.14232776
108P300_18555785_Chip-Seq_ESCs_Mouse1.13108933
109TCF4_23295773_ChIP-Seq_U87_Human1.11669356
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10968400
111ETV1_20927104_ChIP-Seq_GIST48_Human1.10948529
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10566072
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10541554
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10391814
115* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09763639
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09577975
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08261890
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06905605
119NANOG_19829295_ChIP-Seq_ESCs_Human1.06714863
120SOX2_19829295_ChIP-Seq_ESCs_Human1.06714863
121* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06321823
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.05685344
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05564061
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04787620
125GF1B_26923725_Chip-Seq_HPCs_Mouse1.04569184
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.04393802
127TP53_18474530_ChIP-ChIP_U2OS_Human1.04390499
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04371022
129KDM2B_26808549_Chip-Seq_REH_Human1.04214839
130AR_19668381_ChIP-Seq_PC3_Human1.03643736
131EP300_21415370_ChIP-Seq_HL-1_Mouse1.03419892
132AR_21572438_ChIP-Seq_LNCaP_Human1.03293926
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03270658
134* RXR_22108803_ChIP-Seq_LS180_Human1.02997488
135CDX2_22108803_ChIP-Seq_LS180_Human1.01985997
136OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01771621
137NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00563165
138PHF8_20622853_ChIP-Seq_HELA_Human1.00094972
139HNFA_21074721_ChIP-Seq_CACO-2_Human0.99484091
140NFYB_21822215_ChIP-Seq_K562_Human0.99378125
141RBPJ_21746931_ChIP-Seq_IB4_Human0.99233198
142EZH2_22144423_ChIP-Seq_EOC_Human0.98290019
143PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97017627
144* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97005448
145AR_25329375_ChIP-Seq_VCAP_Human0.95886511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.41554550
2MP0002102_abnormal_ear_morphology4.35341222
3MP0003646_muscle_fatigue4.27343634
4MP0006292_abnormal_olfactory_placode4.00952337
5MP0003718_maternal_effect3.70887068
6MP0003693_abnormal_embryo_hatching3.49985915
7MP0008877_abnormal_DNA_methylation3.39482616
8MP0002653_abnormal_ependyma_morphology2.96155741
9MP0003111_abnormal_nucleus_morphology2.92888155
10MP0003787_abnormal_imprinting2.81037066
11MP0000566_synostosis2.78642833
12MP0003195_calcinosis2.77669451
13MP0010094_abnormal_chromosome_stability2.60428617
14MP0005551_abnormal_eye_electrophysiolog2.37403198
15MP0003077_abnormal_cell_cycle2.35016122
16MP0009046_muscle_twitch2.34701296
17MP0005646_abnormal_pituitary_gland2.32274915
18MP0001968_abnormal_touch/_nociception2.23763631
19MP0001501_abnormal_sleep_pattern2.16769080
20MP0003136_yellow_coat_color2.12669251
21MP0004043_abnormal_pH_regulation2.10483496
22MP0008058_abnormal_DNA_repair2.07757769
23MP0002736_abnormal_nociception_after2.05285066
24MP0001119_abnormal_female_reproductive2.00474685
25MP0009745_abnormal_behavioral_response1.91963769
26MP0002249_abnormal_larynx_morphology1.91606499
27MP0005408_hypopigmentation1.89477034
28MP0001486_abnormal_startle_reflex1.89381894
29MP0000579_abnormal_nail_morphology1.87707822
30MP0002210_abnormal_sex_determination1.83933203
31MP0001929_abnormal_gametogenesis1.78761475
32MP0008057_abnormal_DNA_replication1.78259471
33MP0005395_other_phenotype1.77689985
34MP0003699_abnormal_female_reproductive1.75385044
35MP0003880_abnormal_central_pattern1.74924404
36MP0005253_abnormal_eye_physiology1.74019484
37MP0001485_abnormal_pinna_reflex1.69782936
38MP0006276_abnormal_autonomic_nervous1.69299536
39MP0000653_abnormal_sex_gland1.67129754
40MP0003121_genomic_imprinting1.61609583
41MP0008007_abnormal_cellular_replicative1.61470989
42MP0000778_abnormal_nervous_system1.60180780
43MP0001346_abnormal_lacrimal_gland1.56821148
44MP0002735_abnormal_chemical_nociception1.55330273
45MP0002272_abnormal_nervous_system1.55203856
46MP0005171_absent_coat_pigmentation1.51498697
47* MP0003937_abnormal_limbs/digits/tail_de1.50961321
48MP0004142_abnormal_muscle_tone1.49677937
49MP0004957_abnormal_blastocyst_morpholog1.47094581
50MP0002064_seizures1.46585501
51MP0002572_abnormal_emotion/affect_behav1.46030838
52MP0005174_abnormal_tail_pigmentation1.44568716
53MP0003635_abnormal_synaptic_transmissio1.42816773
54MP0003315_abnormal_perineum_morphology1.42724560
55MP0005248_abnormal_Harderian_gland1.39374507
56MP0002557_abnormal_social/conspecific_i1.34233918
57MP0001145_abnormal_male_reproductive1.33726691
58MP0000538_abnormal_urinary_bladder1.33322523
59MP0002067_abnormal_sensory_capabilities1.32092335
60MP0004924_abnormal_behavior1.31358254
61MP0005386_behavior/neurological_phenoty1.31358254
62MP0008932_abnormal_embryonic_tissue1.29138543
63MP0003045_fibrosis1.28601191
64MP0008995_early_reproductive_senescence1.27310233
65MP0000678_abnormal_parathyroid_gland1.27001614
66MP0003755_abnormal_palate_morphology1.26122019
67MP0002928_abnormal_bile_duct1.24736811
68MP0002063_abnormal_learning/memory/cond1.24641651
69MP0005187_abnormal_penis_morphology1.21011156
70MP0000427_abnormal_hair_cycle1.19763725
71MP0004885_abnormal_endolymph1.18942213
72MP0004215_abnormal_myocardial_fiber1.18444696
73MP0004133_heterotaxia1.17394375
74MP0002638_abnormal_pupillary_reflex1.16768417
75MP0004145_abnormal_muscle_electrophysio1.15930915
76MP0001970_abnormal_pain_threshold1.15810614
77MP0001529_abnormal_vocalization1.15655709
78MP0002168_other_aberrant_phenotype1.13513902
79MP0005645_abnormal_hypothalamus_physiol1.11183193
80MP0003119_abnormal_digestive_system1.08512135
81MP0005195_abnormal_posterior_eye1.07887288
82MP0002734_abnormal_mechanical_nocicepti1.07806868
83MP0008872_abnormal_physiological_respon1.07475482
84MP0003123_paternal_imprinting1.06895178
85* MP0002085_abnormal_embryonic_tissue1.06770878
86MP0002234_abnormal_pharynx_morphology1.06323050
87MP0005377_hearing/vestibular/ear_phenot1.05628167
88MP0003878_abnormal_ear_physiology1.05628167
89MP0010386_abnormal_urinary_bladder1.05064737
90MP0000462_abnormal_digestive_system1.04574551
91MP0004147_increased_porphyrin_level1.04104226
92MP0010678_abnormal_skin_adnexa1.03489964
93MP0002733_abnormal_thermal_nociception1.02716570
94MP0002233_abnormal_nose_morphology1.00170545
95MP0008789_abnormal_olfactory_epithelium0.98427092
96MP0008961_abnormal_basal_metabolism0.97980144
97MP0003950_abnormal_plasma_membrane0.97776444
98MP0002876_abnormal_thyroid_physiology0.96853465
99MP0002161_abnormal_fertility/fecundity0.96799252
100MP0003890_abnormal_embryonic-extraembry0.96239828
101MP0002877_abnormal_melanocyte_morpholog0.95825759
102MP0003633_abnormal_nervous_system0.95789152
103MP0003941_abnormal_skin_development0.94492639
104* MP0002882_abnormal_neuron_morphology0.93972559
105MP0003698_abnormal_male_reproductive0.93750046
106MP0002184_abnormal_innervation0.93491285
107MP0005670_abnormal_white_adipose0.93314230
108MP0002177_abnormal_outer_ear0.93281844
109MP0000432_abnormal_head_morphology0.91887192
110MP0004742_abnormal_vestibular_system0.91025986
111MP0004130_abnormal_muscle_cell0.89954831
112MP0006072_abnormal_retinal_apoptosis0.89815069
113MP0002116_abnormal_craniofacial_bone0.89512491
114MP0001963_abnormal_hearing_physiology0.89172809
115MP0003938_abnormal_ear_development0.89135333
116MP0005379_endocrine/exocrine_gland_phen0.89057175
117MP0002095_abnormal_skin_pigmentation0.88989775
118MP0003137_abnormal_impulse_conducting0.88287652
119MP0000613_abnormal_salivary_gland0.88227263
120MP0003786_premature_aging0.88069780
121MP0010030_abnormal_orbit_morphology0.87890548
122MP0005391_vision/eye_phenotype0.87492614
123MP0001188_hyperpigmentation0.87323235
124MP0002229_neurodegeneration0.86377637
125MP0001324_abnormal_eye_pigmentation0.84641209
126MP0003252_abnormal_bile_duct0.84240825
127MP0005257_abnormal_intraocular_pressure0.83184347
128MP0004859_abnormal_synaptic_plasticity0.82662480
129MP0009250_abnormal_appendicular_skeleto0.82479852
130MP0002837_dystrophic_cardiac_calcinosis0.82413936
131MP0000569_abnormal_digit_pigmentation0.82388641
132MP0004782_abnormal_surfactant_physiolog0.82314402
133MP0002163_abnormal_gland_morphology0.81620809
134MP0003935_abnormal_craniofacial_develop0.81551265
135MP0005389_reproductive_system_phenotype0.80683597
136MP0004085_abnormal_heartbeat0.80629802
137MP0002277_abnormal_respiratory_mucosa0.80375161
138MP0010307_abnormal_tumor_latency0.79551493
139MP0001672_abnormal_embryogenesis/_devel0.79546207
140MP0005380_embryogenesis_phenotype0.79546207
141MP0000350_abnormal_cell_proliferation0.79291879
142MP0001986_abnormal_taste_sensitivity0.79035575
143MP0000230_abnormal_systemic_arterial0.78928958
144MP0002751_abnormal_autonomic_nervous0.78611127
145MP0005647_abnormal_sex_gland0.78125131
146* MP0000955_abnormal_spinal_cord0.78071727
147MP0003631_nervous_system_phenotype0.77708379
148MP0006054_spinal_hemorrhage0.77508646
149MP0008260_abnormal_autophagy0.77212280
150MP0000026_abnormal_inner_ear0.77198044
151MP0005310_abnormal_salivary_gland0.76672887
152MP0002938_white_spotting0.76653183
153MP0000372_irregular_coat_pigmentation0.76464574
154MP0001286_abnormal_eye_development0.73865151
155MP0002160_abnormal_reproductive_system0.71764638
156MP0004381_abnormal_hair_follicle0.71672054
157MP0010368_abnormal_lymphatic_system0.71399874
158MP0005394_taste/olfaction_phenotype0.71229739
159MP0005499_abnormal_olfactory_system0.71229739
160MP0001502_abnormal_circadian_rhythm0.70874602
161* MP0002084_abnormal_developmental_patter0.70365479
162MP0000631_abnormal_neuroendocrine_gland0.70041747
163MP0002127_abnormal_cardiovascular_syste0.69547186
164MP0002752_abnormal_somatic_nervous0.67353595
165MP0000383_abnormal_hair_follicle0.66865074
166MP0005197_abnormal_uvea_morphology0.66375153
167* MP0003861_abnormal_nervous_system0.64925742
168MP0001984_abnormal_olfaction0.64508503

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.54156678
2Chromsome breakage (HP:0040012)6.14780849
3Male infertility (HP:0003251)4.86079782
4Genetic anticipation (HP:0003743)4.64363034
5Papillary thyroid carcinoma (HP:0002895)4.63633421
6Hyperventilation (HP:0002883)4.40911405
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.09449190
8Progressive cerebellar ataxia (HP:0002073)3.94187190
9Gaze-evoked nystagmus (HP:0000640)3.75146531
10Birth length less than 3rd percentile (HP:0003561)3.75108932
11Facial hemangioma (HP:0000329)3.63124135
12Abnormality of the labia minora (HP:0012880)3.56872376
13Prostate neoplasm (HP:0100787)3.53462130
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.48566429
15Patellar aplasia (HP:0006443)3.42541598
16Abnormality of the preputium (HP:0100587)3.39371941
17Breast hypoplasia (HP:0003187)3.34559688
18Chronic hepatic failure (HP:0100626)3.32176951
19Abnormal respiratory motile cilium physiology (HP:0012261)3.31849751
20Shawl scrotum (HP:0000049)3.30324518
21Meckel diverticulum (HP:0002245)3.26116470
22Abnormality of chromosome stability (HP:0003220)3.22737738
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.17779414
24Hypoplasia of the fovea (HP:0007750)3.17779414
25Protruding tongue (HP:0010808)3.15131429
26Abnormality of the renal cortex (HP:0011035)3.10926362
27Capillary hemangiomas (HP:0005306)3.07543943
28Aplasia/Hypoplasia of the patella (HP:0006498)3.07010635
29Abnormality of the ileum (HP:0001549)3.05130539
30Aplasia/Hypoplasia of the tibia (HP:0005772)3.04551782
31Pancreatic fibrosis (HP:0100732)3.00642232
32Medial flaring of the eyebrow (HP:0010747)2.99374047
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.94684191
34Absent/shortened dynein arms (HP:0200106)2.94684191
35Febrile seizures (HP:0002373)2.86336675
36Abnormality of the fovea (HP:0000493)2.84138606
37Congenital stationary night blindness (HP:0007642)2.84041117
38Abnormal ciliary motility (HP:0012262)2.77773910
39Abnormality of the fingertips (HP:0001211)2.75304081
40Ectopic kidney (HP:0000086)2.72466653
41Clubbing of toes (HP:0100760)2.71119051
42Aplasia/Hypoplasia of the breasts (HP:0010311)2.69593067
43Breast aplasia (HP:0100783)2.68309438
44Oligodactyly (hands) (HP:0001180)2.67558715
45Clumsiness (HP:0002312)2.65596317
46Supernumerary spleens (HP:0009799)2.63549525
47Gait imbalance (HP:0002141)2.63070059
48Tubular atrophy (HP:0000092)2.61854150
49Attenuation of retinal blood vessels (HP:0007843)2.61422590
50Broad-based gait (HP:0002136)2.59060603
51Adrenal hypoplasia (HP:0000835)2.58288694
52Thyroid carcinoma (HP:0002890)2.55515573
53Congenital primary aphakia (HP:0007707)2.54663760
54Focal seizures (HP:0007359)2.53268819
55True hermaphroditism (HP:0010459)2.51254530
56Pancreatic cysts (HP:0001737)2.46824163
57Congenital hepatic fibrosis (HP:0002612)2.46341879
58Abnormal respiratory motile cilium morphology (HP:0005938)2.46327804
59Abnormal respiratory epithelium morphology (HP:0012253)2.46327804
60Fair hair (HP:0002286)2.45770863
61Genital tract atresia (HP:0001827)2.44274187
62Flat capital femoral epiphysis (HP:0003370)2.43724817
63Rhinitis (HP:0012384)2.42254537
64Focal motor seizures (HP:0011153)2.41223726
65Abnormality of the ischium (HP:0003174)2.39928603
66Oligodactyly (HP:0012165)2.37595695
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37425081
68Vaginal atresia (HP:0000148)2.36105968
69Preaxial foot polydactyly (HP:0001841)2.35850527
70Sclerocornea (HP:0000647)2.34300093
71Anencephaly (HP:0002323)2.34003179
72Insulin-resistant diabetes mellitus (HP:0000831)2.32262957
73Dialeptic seizures (HP:0011146)2.31271418
74Hypoplastic ischia (HP:0003175)2.30771353
75Bony spicule pigmentary retinopathy (HP:0007737)2.28683675
76Azoospermia (HP:0000027)2.26451630
77Nephrogenic diabetes insipidus (HP:0009806)2.25164921
78Small intestinal stenosis (HP:0012848)2.25050585
79Duodenal stenosis (HP:0100867)2.25050585
80Absent radius (HP:0003974)2.24279595
81Lip pit (HP:0100267)2.23760414
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.22771825
83Volvulus (HP:0002580)2.20964314
84Furrowed tongue (HP:0000221)2.18856712
85Abnormality of the carotid arteries (HP:0005344)2.18769334
86Abolished electroretinogram (ERG) (HP:0000550)2.18592842
87Cerebellar dysplasia (HP:0007033)2.17325176
88Intestinal atresia (HP:0011100)2.15919851
89Type II lissencephaly (HP:0007260)2.15711939
90Central scotoma (HP:0000603)2.15394565
91Chronic bronchitis (HP:0004469)2.15154182
92Absent forearm bone (HP:0003953)2.14889562
93Aplasia involving forearm bones (HP:0009822)2.14889562
94Short thumb (HP:0009778)2.13001461
95Cystic hygroma (HP:0000476)2.10786845
96Hypoplastic labia majora (HP:0000059)2.10672904
97Midline defect of the nose (HP:0004122)2.09557123
98Inability to walk (HP:0002540)2.09500033
99Aplasia/Hypoplasia of the macula (HP:0008059)2.08132361
100Abnormality of lateral ventricle (HP:0030047)2.08070472
101Widely spaced teeth (HP:0000687)2.07804854
102Keratoconus (HP:0000563)2.07511714
103Increased corneal curvature (HP:0100692)2.07511714
104Acute myeloid leukemia (HP:0004808)2.05886455
105Abnormal drinking behavior (HP:0030082)2.05611594
106Polydipsia (HP:0001959)2.05611594
107Short foot (HP:0001773)2.05400172
108Nephronophthisis (HP:0000090)2.04499770
109Molar tooth sign on MRI (HP:0002419)2.03796506
110Abnormality of midbrain morphology (HP:0002418)2.03796506
111Drooling (HP:0002307)2.02800957
112Nephroblastoma (Wilms tumor) (HP:0002667)2.02534285
113Congenital sensorineural hearing impairment (HP:0008527)2.01859217
114Abnormal spermatogenesis (HP:0008669)2.01427376
115Abnormality of the renal collecting system (HP:0004742)2.00907733
116Absence seizures (HP:0002121)1.99771657
117Infertility (HP:0000789)1.99432897
118Abnormality of chromosome segregation (HP:0002916)1.97561791
119Duplicated collecting system (HP:0000081)1.96670862
120Progressive inability to walk (HP:0002505)1.95058575
121Abnormality of the labia majora (HP:0012881)1.94110374
122Hemiparesis (HP:0001269)1.94053743
123Tubulointerstitial nephritis (HP:0001970)1.93822449
124Type 2 muscle fiber atrophy (HP:0003554)1.93391728
125Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93111290
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.92954223
127Atonic seizures (HP:0010819)1.89527564
128Renal cortical cysts (HP:0000803)1.88807140
129Abnormality of the renal medulla (HP:0100957)1.88559676
130Decreased circulating renin level (HP:0003351)1.88496598
131Large for gestational age (HP:0001520)1.87573335
132Highly arched eyebrow (HP:0002553)1.86993686
133Absent eyebrow (HP:0002223)1.86470989
134Sloping forehead (HP:0000340)1.84909117
135Embryonal renal neoplasm (HP:0011794)1.84361812
136Tented upper lip vermilion (HP:0010804)1.84175509
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.83967161
138Generalized hypopigmentation of hair (HP:0011358)1.83142430
139Postaxial hand polydactyly (HP:0001162)1.83015192
140Absent septum pellucidum (HP:0001331)1.82801364
141Abnormality of macular pigmentation (HP:0008002)1.82366217
142Septo-optic dysplasia (HP:0100842)1.81800891
143Cutaneous finger syndactyly (HP:0010554)1.81632907
144Abnormality of the duodenum (HP:0002246)1.80568774
145Abnormality of the septum pellucidum (HP:0007375)1.80333539
146Small hand (HP:0200055)1.79555504
147Decreased central vision (HP:0007663)1.78804747
148Primary amenorrhea (HP:0000786)1.78269217
149Excessive salivation (HP:0003781)1.78255122
150Stomach cancer (HP:0012126)1.77710998
151Cupped ear (HP:0000378)1.77434085
152Poor coordination (HP:0002370)1.77241545
153Astigmatism (HP:0000483)1.77054449
154Abnormal biliary tract physiology (HP:0012439)1.76505897
155Bile duct proliferation (HP:0001408)1.76505897
156Lissencephaly (HP:0001339)1.76464910
157Preaxial hand polydactyly (HP:0001177)1.76387556
158Abnormality of the phalanges of the hallux (HP:0010057)1.75941973
159Male pseudohermaphroditism (HP:0000037)1.75237587
160Hyperglycemia (HP:0003074)1.74389891
161Bifid tongue (HP:0010297)1.74172052
162Myelodysplasia (HP:0002863)1.73918125
163Microglossia (HP:0000171)1.73761583
164Bronchiectasis (HP:0002110)1.70795166
165Anterior segment dysgenesis (HP:0007700)1.70094956
166Postaxial foot polydactyly (HP:0001830)1.69694477
167Rib fusion (HP:0000902)1.68488099
168Median cleft lip (HP:0000161)1.68410453
169Atrial fibrillation (HP:0005110)1.67461936
170Absent speech (HP:0001344)1.67455996
171Aplasia/Hypoplasia affecting the retina (HP:0008061)1.67416909
172Occipital encephalocele (HP:0002085)1.67290388
173Abnormality of incisor morphology (HP:0011063)1.66903177
174Secondary amenorrhea (HP:0000869)1.66147282
175Cystic liver disease (HP:0006706)1.64641333
176Bone marrow hypocellularity (HP:0005528)1.64346145
177Hypoplastic iliac wings (HP:0002866)1.64340012
178Hypergonadotropic hypogonadism (HP:0000815)1.63248865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.83128567
2STK38L4.19016686
3LATS24.09010757
4MAP3K63.81685546
5ERBB43.14062487
6PLK43.06987268
7BMPR1B2.97830396
8MUSK2.96812722
9CDC72.56858455
10SRPK12.51982040
11TTK2.39827039
12WNK32.09490162
13ADRBK22.00286284
14PNCK1.90809982
15STK31.86505635
16CDK31.76889887
17CDK81.76727206
18DYRK21.73021065
19CHEK21.72719359
20NTRK31.67729545
21NUAK11.64414696
22PRKD31.64183704
23MAP3K131.64135623
24MAP2K71.62078300
25TAOK31.58521775
26AKT31.50569757
27GRK11.48796803
28DMPK1.48733147
29STK381.47271212
30BRSK21.44164421
31PLK11.43417074
32MARK11.39179756
33STK391.38232252
34BRAF1.36569304
35MAP4K21.34250921
36MAPK131.30580411
37PLK31.27858920
38EEF2K1.27316075
39KSR21.27227996
40OXSR11.27102586
41CDK91.24926513
42RAF11.21925096
43EPHA41.20962586
44MKNK21.19589940
45CAMK1G1.19355662
46CDK121.18850741
47MELK1.16015439
48MAP3K41.15033308
49MAPK151.12830473
50SGK21.10609335
51TGFBR11.10434172
52ADRBK11.10379916
53NEK21.05270643
54EIF2AK21.04516740
55WNK41.03365143
56KSR11.03044473
57NEK61.02390680
58AURKB0.98678950
59PRKAA20.96159491
60FRK0.94936503
61FGFR20.92833100
62STK240.92819828
63PIK3CG0.91811721
64NLK0.91378929
65ATM0.91290163
66PAK30.90388510
67CAMK1D0.88716997
68BRSK10.88671977
69PAK60.87363914
70PTK2B0.87037587
71PRKAA10.84116249
72PRKCG0.83180478
73DAPK20.82734257
74PRKCE0.82522313
75ZAK0.80975291
76EPHA30.79379231
77MAP3K90.79132585
78NTRK20.79029170
79PIK3CA0.77976819
80AURKA0.77329523
81CHEK10.77060993
82VRK10.75603734
83MAP3K70.73882449
84BRD40.71988180
85CDK70.71830936
86STK40.70213326
87ATR0.65011276
88EPHB20.62951973
89ERBB20.62309360
90TRPM70.61042712
91ACVR1B0.60436866
92HIPK20.60154710
93FER0.59949175
94PKN10.59419826
95TEC0.58076427
96MAP3K50.58032335
97IRAK30.58014241
98TNIK0.57442417
99CSNK1G10.57132144
100SGK4940.56352497
101SGK2230.56352497
102MAPKAPK30.55645110
103MAPKAPK50.55018272
104IRAK10.54547420
105CASK0.54497711
106SGK30.54184717
107CAMK10.53241065
108CDK10.52292527
109BCR0.51402587
110ABL20.50188530
111CAMKK20.48559752
112WEE10.47245472
113MKNK10.45863463
114SGK10.44764903
115CHUK0.44580579
116MARK30.44380283
117CAMK40.43409289
118DYRK30.43122576
119STK110.42225935
120MAPK100.41755907
121CDK20.41726090
122TYRO30.41606395
123CSNK1D0.41526070
124TNK20.41435690
125CAMK2A0.40367437
126CSNK1A1L0.39309315
127CSNK1G20.38800883
128DYRK1A0.38650630
129TLK10.38591612
130NEK90.37965191
131MAPK110.37945259
132WNK10.37641321
133SIK20.37238766
134PRKD20.36844149
135CCNB10.36544950
136PLK20.35773723
137PRKG10.34528094
138INSRR0.34162911
139ERBB30.33828446
140OBSCN0.33372807
141PRKACB0.32864732
142PRKACA0.32588174
143AKT10.31476480
144MOS0.30770432
145RPS6KA30.29761459
146ABL10.28456323
147FLT30.28230389
148PINK10.27972812
149MAPK140.27644450
150CSNK1A10.27357760
151MAP2K40.27048470
152GSK3B0.26913202
153TXK0.26435384
154TIE10.26425582
155CDK40.25318862

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.99482196
2Fanconi anemia pathway_Homo sapiens_hsa034603.80745323
3Basal transcription factors_Homo sapiens_hsa030223.57519369
4RNA degradation_Homo sapiens_hsa030182.89535922
5Homologous recombination_Homo sapiens_hsa034402.88403501
6Circadian rhythm_Homo sapiens_hsa047102.85295484
7Vitamin B6 metabolism_Homo sapiens_hsa007502.63505868
8Butanoate metabolism_Homo sapiens_hsa006502.48142444
9RNA polymerase_Homo sapiens_hsa030202.30993427
10Ovarian steroidogenesis_Homo sapiens_hsa049132.18951197
11Nitrogen metabolism_Homo sapiens_hsa009102.15636745
12ABC transporters_Homo sapiens_hsa020102.11287352
13TGF-beta signaling pathway_Homo sapiens_hsa043502.07323237
14Tryptophan metabolism_Homo sapiens_hsa003802.01549962
15Non-homologous end-joining_Homo sapiens_hsa034501.84538163
16Morphine addiction_Homo sapiens_hsa050321.80490215
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78915532
18Circadian entrainment_Homo sapiens_hsa047131.75825527
19p53 signaling pathway_Homo sapiens_hsa041151.75593276
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68204723
21RNA transport_Homo sapiens_hsa030131.67875277
22Oocyte meiosis_Homo sapiens_hsa041141.64837986
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.63395574
24Mismatch repair_Homo sapiens_hsa034301.61581457
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.60419863
26mRNA surveillance pathway_Homo sapiens_hsa030151.59792946
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59119476
28Linoleic acid metabolism_Homo sapiens_hsa005911.54218239
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50396792
30GABAergic synapse_Homo sapiens_hsa047271.48909176
31Pancreatic cancer_Homo sapiens_hsa052121.47343349
32Ether lipid metabolism_Homo sapiens_hsa005651.46934495
33Histidine metabolism_Homo sapiens_hsa003401.45285160
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44296087
35Nucleotide excision repair_Homo sapiens_hsa034201.42605701
36Salivary secretion_Homo sapiens_hsa049701.41791586
37Sphingolipid metabolism_Homo sapiens_hsa006001.38046880
38Calcium signaling pathway_Homo sapiens_hsa040201.36471341
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36382625
40MicroRNAs in cancer_Homo sapiens_hsa052061.32887372
41Dorso-ventral axis formation_Homo sapiens_hsa043201.32672720
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31761477
43Propanoate metabolism_Homo sapiens_hsa006401.30506617
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25375168
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23931343
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23777958
47Glycerolipid metabolism_Homo sapiens_hsa005611.22505029
48Other glycan degradation_Homo sapiens_hsa005111.20221966
49Base excision repair_Homo sapiens_hsa034101.16141311
50Retinol metabolism_Homo sapiens_hsa008301.15008100
51Prolactin signaling pathway_Homo sapiens_hsa049171.13345067
52Chemical carcinogenesis_Homo sapiens_hsa052041.11994493
53Selenocompound metabolism_Homo sapiens_hsa004501.10147295
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08292053
55Hippo signaling pathway_Homo sapiens_hsa043901.06783528
56Purine metabolism_Homo sapiens_hsa002301.06422789
57Cholinergic synapse_Homo sapiens_hsa047251.02387021
58beta-Alanine metabolism_Homo sapiens_hsa004101.01289180
59GnRH signaling pathway_Homo sapiens_hsa049121.00256003
60Phototransduction_Homo sapiens_hsa047440.99456126
61Colorectal cancer_Homo sapiens_hsa052100.99202448
62Choline metabolism in cancer_Homo sapiens_hsa052310.99004951
63Dopaminergic synapse_Homo sapiens_hsa047280.95851672
64Gastric acid secretion_Homo sapiens_hsa049710.94971638
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92609869
66Oxytocin signaling pathway_Homo sapiens_hsa049210.92440210
67Arachidonic acid metabolism_Homo sapiens_hsa005900.92250136
68Caffeine metabolism_Homo sapiens_hsa002320.92017033
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89854055
70Lysine degradation_Homo sapiens_hsa003100.88590019
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88230461
72Fatty acid biosynthesis_Homo sapiens_hsa000610.87851610
73Basal cell carcinoma_Homo sapiens_hsa052170.87529754
74Adherens junction_Homo sapiens_hsa045200.86058918
75Renin secretion_Homo sapiens_hsa049240.84948577
76Dilated cardiomyopathy_Homo sapiens_hsa054140.84710601
77FoxO signaling pathway_Homo sapiens_hsa040680.84106879
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84026944
79Pyrimidine metabolism_Homo sapiens_hsa002400.83701099
80Herpes simplex infection_Homo sapiens_hsa051680.81660086
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80936559
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80224004
83Small cell lung cancer_Homo sapiens_hsa052220.80080311
84DNA replication_Homo sapiens_hsa030300.79975861
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79656470
86Prostate cancer_Homo sapiens_hsa052150.77660127
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77379589
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77320297
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75405982
90Inositol phosphate metabolism_Homo sapiens_hsa005620.75307125
91Wnt signaling pathway_Homo sapiens_hsa043100.74170710
92Endometrial cancer_Homo sapiens_hsa052130.73872157
93Renal cell carcinoma_Homo sapiens_hsa052110.73650809
94Amphetamine addiction_Homo sapiens_hsa050310.73102111
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.71269677
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67991531
97cAMP signaling pathway_Homo sapiens_hsa040240.67832862
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.67597657
99Axon guidance_Homo sapiens_hsa043600.66626791
100Serotonergic synapse_Homo sapiens_hsa047260.64489867
101Melanoma_Homo sapiens_hsa052180.64488986
102Pancreatic secretion_Homo sapiens_hsa049720.63485524
103Nicotine addiction_Homo sapiens_hsa050330.62721770
104Hedgehog signaling pathway_Homo sapiens_hsa043400.59393155
105HTLV-I infection_Homo sapiens_hsa051660.59050192
106Notch signaling pathway_Homo sapiens_hsa043300.57688460
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56660568
108Hepatitis B_Homo sapiens_hsa051610.56613309
109Ras signaling pathway_Homo sapiens_hsa040140.56303874
110Fatty acid degradation_Homo sapiens_hsa000710.55559244
111Cocaine addiction_Homo sapiens_hsa050300.52330988
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51748406
113Peroxisome_Homo sapiens_hsa041460.50884772
114MAPK signaling pathway_Homo sapiens_hsa040100.50551516
115Insulin secretion_Homo sapiens_hsa049110.50521654
116Pathways in cancer_Homo sapiens_hsa052000.49733850
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49663426
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48338642
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.47660488
120Bile secretion_Homo sapiens_hsa049760.47097192
121ErbB signaling pathway_Homo sapiens_hsa040120.45508605
122Glutamatergic synapse_Homo sapiens_hsa047240.43494447
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42338369
124Melanogenesis_Homo sapiens_hsa049160.42215793
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42020091
126Thyroid cancer_Homo sapiens_hsa052160.41822193
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41451783
128Glucagon signaling pathway_Homo sapiens_hsa049220.41373444
129mTOR signaling pathway_Homo sapiens_hsa041500.41087959
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40971841
131Type II diabetes mellitus_Homo sapiens_hsa049300.40068992
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38915249
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.37694503
134Olfactory transduction_Homo sapiens_hsa047400.37428217
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36976680
136Regulation of autophagy_Homo sapiens_hsa041400.36672269
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36570876
138TNF signaling pathway_Homo sapiens_hsa046680.36183182
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33926280
140Long-term depression_Homo sapiens_hsa047300.33549423
141Taste transduction_Homo sapiens_hsa047420.33493212
142Estrogen signaling pathway_Homo sapiens_hsa049150.33092452
143One carbon pool by folate_Homo sapiens_hsa006700.32944406
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32818516
145Arginine and proline metabolism_Homo sapiens_hsa003300.32554294
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32073910
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.32024153
148Mineral absorption_Homo sapiens_hsa049780.31968222
149Thyroid hormone synthesis_Homo sapiens_hsa049180.31947148
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.31268084
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31006328
152Influenza A_Homo sapiens_hsa051640.30718917
153Viral carcinogenesis_Homo sapiens_hsa052030.29565700

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