IP6K1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.37064735
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36171906
3locomotory exploration behavior (GO:0035641)5.34101652
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86643083
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61881461
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.20174450
7vocalization behavior (GO:0071625)4.12078768
8glutamate secretion (GO:0014047)4.08517874
9regulation of synaptic vesicle exocytosis (GO:2000300)4.07629437
10sodium ion export (GO:0071436)4.03763156
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03446117
12protein localization to endosome (GO:0036010)4.01115651
13layer formation in cerebral cortex (GO:0021819)3.98109684
14synaptic vesicle exocytosis (GO:0016079)3.93079180
15regulation of glutamate receptor signaling pathway (GO:1900449)3.90150497
16negative regulation of erythrocyte differentiation (GO:0045647)3.87106270
17neurotransmitter secretion (GO:0007269)3.80463480
18regulation of ARF protein signal transduction (GO:0032012)3.78884928
19exploration behavior (GO:0035640)3.76544873
20activation of protein kinase A activity (GO:0034199)3.70885001
21regulation of synaptic vesicle transport (GO:1902803)3.66335786
22regulation of synapse structural plasticity (GO:0051823)3.65324294
23cellular potassium ion homeostasis (GO:0030007)3.64943033
24regulation of neuronal synaptic plasticity (GO:0048168)3.61861600
25gamma-aminobutyric acid transport (GO:0015812)3.52687312
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52326060
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.51936333
28proline transport (GO:0015824)3.50684299
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.45904944
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43623183
31protein localization to synapse (GO:0035418)3.38306384
32neurotransmitter-gated ion channel clustering (GO:0072578)3.38111302
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34121111
34cerebellar Purkinje cell differentiation (GO:0021702)3.29701628
35neuromuscular process controlling balance (GO:0050885)3.27727841
36regulation of NFAT protein import into nucleus (GO:0051532)3.24872759
37glycine transport (GO:0015816)3.24315275
38dendritic spine morphogenesis (GO:0060997)3.22805300
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20024390
40long-term memory (GO:0007616)3.19669381
41negative regulation of cell killing (GO:0031342)3.19399546
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.19399546
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16531506
44cerebellar granule cell differentiation (GO:0021707)3.14618545
45potassium ion import (GO:0010107)3.09257439
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05873256
47amino acid import (GO:0043090)3.04741874
48cell communication by electrical coupling (GO:0010644)3.01852096
49prepulse inhibition (GO:0060134)3.01053762
50synaptic transmission, glutamatergic (GO:0035249)2.99032776
51positive regulation of membrane potential (GO:0045838)2.97165067
52regulation of early endosome to late endosome transport (GO:2000641)2.96023200
53cytoskeletal anchoring at plasma membrane (GO:0007016)2.95916745
54glutamate receptor signaling pathway (GO:0007215)2.94108043
55dendrite morphogenesis (GO:0048813)2.94055670
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92488366
57neurotransmitter transport (GO:0006836)2.91454807
58cellular sodium ion homeostasis (GO:0006883)2.89931083
59regulation of ARF GTPase activity (GO:0032312)2.89928979
60membrane depolarization during action potential (GO:0086010)2.89860575
61adenosine receptor signaling pathway (GO:0001973)2.87507040
62positive regulation of synapse maturation (GO:0090129)2.86313227
63neuronal action potential propagation (GO:0019227)2.84886407
64vesicle transport along microtubule (GO:0047496)2.83792765
65signal complex assembly (GO:0007172)2.81511329
66cerebellar Purkinje cell layer development (GO:0021680)2.80505364
67alanine transport (GO:0032328)2.79534044
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79506227
69neuron cell-cell adhesion (GO:0007158)2.79164123
70protein targeting to plasma membrane (GO:0072661)2.77105939
71regulation of synaptic plasticity (GO:0048167)2.76821449
72positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76191522
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75610643
74negative regulation of cell size (GO:0045792)2.74751928
75regulation of postsynaptic membrane potential (GO:0060078)2.74589550
76auditory behavior (GO:0031223)2.74159190
77neuron-neuron synaptic transmission (GO:0007270)2.73080306
78response to muramyl dipeptide (GO:0032495)2.70089322
79regulation of neurotransmitter levels (GO:0001505)2.69861821
80regulation of clathrin-mediated endocytosis (GO:2000369)2.69547127
81regulation of neurotransmitter secretion (GO:0046928)2.69254771
82synaptic vesicle endocytosis (GO:0048488)2.66735432
83long-term synaptic potentiation (GO:0060291)2.66378741
84regulation of dendritic spine morphogenesis (GO:0061001)2.65346398
85response to auditory stimulus (GO:0010996)2.65206630
86positive regulation of protein dephosphorylation (GO:0035307)2.65158406
87clathrin coat assembly (GO:0048268)2.65082997
883-UTR-mediated mRNA stabilization (GO:0070935)2.63451065
89modulation by symbiont of host cellular process (GO:0044068)2.63308632
90protein retention in ER lumen (GO:0006621)2.62944371
91modulation by virus of host process (GO:0019054)2.62378070
92nerve growth factor signaling pathway (GO:0038180)2.61305986
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.60488257
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59935404
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.59935404
96modulation by symbiont of host immune response (GO:0052553)2.59935404
97positive regulation by symbiont of host defense response (GO:0052509)2.59935404
98modulation by symbiont of host defense response (GO:0052031)2.59935404
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59935404
100potassium ion homeostasis (GO:0055075)2.59823849
101L-amino acid import (GO:0043092)2.59365889
102positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.59137202
103regulation of chromatin binding (GO:0035561)2.58682277
104dopamine receptor signaling pathway (GO:0007212)2.58290682
105negative regulation of microtubule polymerization (GO:0031115)2.57693681
106barbed-end actin filament capping (GO:0051016)2.57222138
107stress fiber assembly (GO:0043149)2.55499280
108establishment of nucleus localization (GO:0040023)2.54764794
109regulation of regulated secretory pathway (GO:1903305)2.54528422
110regulation of T-helper 2 cell differentiation (GO:0045628)2.53902362
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.53685443
112membrane depolarization (GO:0051899)2.52829666
113mating behavior (GO:0007617)2.51739579
114axonal fasciculation (GO:0007413)2.51070807
115adherens junction assembly (GO:0034333)2.50829528
116neuromuscular process controlling posture (GO:0050884)2.49972524
117neuron recognition (GO:0008038)2.47817360
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47509064
119innervation (GO:0060384)2.47331270
120cellular response to catecholamine stimulus (GO:0071870)2.47249230
121cellular response to monoamine stimulus (GO:0071868)2.47249230
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46935467
123regulation of neurotransmitter transport (GO:0051588)2.45555982
124positive regulation of receptor recycling (GO:0001921)2.45311961
125positive regulation of neurotransmitter transport (GO:0051590)2.44627463
126membrane repolarization (GO:0086009)2.44350680
127regulation of defense response to virus by virus (GO:0050690)2.43748077
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43706492
129transmission of nerve impulse (GO:0019226)2.43062196
130cAMP biosynthetic process (GO:0006171)2.42706413
131regulation of vesicle fusion (GO:0031338)2.42114080
132positive regulation of synaptic transmission (GO:0050806)2.40881765
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.40757453
134neuronal ion channel clustering (GO:0045161)2.40617477
135calcium ion-dependent exocytosis (GO:0017156)2.40212996
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39653986
137receptor recycling (GO:0001881)2.39537758
138neuromuscular process (GO:0050905)2.39270189
139cell migration in hindbrain (GO:0021535)2.39256877
140regulation of calcium ion-dependent exocytosis (GO:0017158)2.38780113
141regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.37586643
142positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.37586643
143regulation of leukocyte degranulation (GO:0043300)2.36468376
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34370494
145intracellular estrogen receptor signaling pathway (GO:0030520)2.33365697
146cell-cell junction maintenance (GO:0045217)2.33125062
147response to parathyroid hormone (GO:0071107)2.32461869
148positive regulation of Rap GTPase activity (GO:0032854)2.32218447
149establishment of mitochondrion localization (GO:0051654)2.31610614
150maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31000238
151positive regulation of neurotransmitter secretion (GO:0001956)2.30656724
152negative regulation of glial cell proliferation (GO:0060253)2.30006483
153negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.25562847
154regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.23997444
155response to laminar fluid shear stress (GO:0034616)2.23351406
156macrophage activation involved in immune response (GO:0002281)2.22713083
157cortical actin cytoskeleton organization (GO:0030866)2.22103689
158cell-substrate adherens junction assembly (GO:0007045)2.20525775
159focal adhesion assembly (GO:0048041)2.20525775
160mannose metabolic process (GO:0006013)2.20416874
161germinal center formation (GO:0002467)2.19141860
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17818907
163regulation of synapse maturation (GO:0090128)2.16785466
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.15419134
165activation of MAPKKK activity (GO:0000185)2.15068495
166modulation by virus of host morphology or physiology (GO:0019048)2.14172666
167negative regulation of Ras protein signal transduction (GO:0046580)2.14003805
168COPI coating of Golgi vesicle (GO:0048205)2.13610160
169Golgi transport vesicle coating (GO:0048200)2.13610160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40906535
2VDR_21846776_ChIP-Seq_THP-1_Human2.65860436
3DROSHA_22980978_ChIP-Seq_HELA_Human2.64946885
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.59783518
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48371049
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.36786638
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26333442
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23554213
9REST_21632747_ChIP-Seq_MESCs_Mouse2.22073159
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18513927
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14966959
12MYC_22102868_ChIP-Seq_BL_Human2.12035869
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10732897
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09002020
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04541523
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04541523
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99344300
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92669400
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90091590
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89459022
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.88620789
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.85448874
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84966940
24RACK7_27058665_Chip-Seq_MCF-7_Human1.84202562
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82203780
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81372043
27KDM2B_26808549_Chip-Seq_K562_Human1.80922993
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80029945
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.75794573
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75184018
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.74810235
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72475321
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71872069
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71839399
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64455478
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63339795
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63150939
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63144411
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59286264
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58302288
41GBX2_23144817_ChIP-Seq_PC3_Human1.56770728
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54770188
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53917050
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.52745300
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51339837
46* P68_20966046_ChIP-Seq_HELA_Human1.50026062
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49805144
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49449459
49KDM2B_26808549_Chip-Seq_DND41_Human1.46852574
50* SA1_27219007_Chip-Seq_ERYTHROID_Human1.46760433
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.46259307
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.46168939
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45781873
54VDR_24763502_ChIP-Seq_THP-1_Human1.44462342
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42737785
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42093711
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41572265
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.38741879
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.38726288
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37224202
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36102733
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33612699
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33394711
64MAF_26560356_Chip-Seq_TH1_Human1.30775421
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30768681
66CLOCK_20551151_ChIP-Seq_293T_Human1.30730415
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28805104
68* UTX_26944678_Chip-Seq_JUKART_Human1.28552845
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.27323087
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.27281293
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25024072
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25005081
73LXR_22292898_ChIP-Seq_THP-1_Human1.24769232
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24624038
75AR_21572438_ChIP-Seq_LNCaP_Human1.22981993
76GATA1_19941826_ChIP-Seq_K562_Human1.21800466
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21153566
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21114403
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20932225
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20928275
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18491856
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18258557
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18187651
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16823778
85MAF_26560356_Chip-Seq_TH2_Human1.15799254
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15305795
87AR_19668381_ChIP-Seq_PC3_Human1.14499313
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14177193
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13755161
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12479854
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12304581
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.11742347
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10882055
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10372446
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10177074
96* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09339484
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07965398
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07282799
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07264574
100TP53_22127205_ChIP-Seq_IMR90_Human1.06938577
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06901813
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06764942
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06472013
104TCF7_22412390_ChIP-Seq_EML_Mouse1.06392348
105BCOR_27268052_Chip-Seq_Bcells_Human1.05821946
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05776177
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05472261
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.04531697
109NCOR1_26117541_ChIP-Seq_K562_Human1.03675143
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03293979
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03094003
112SPI1_23127762_ChIP-Seq_K562_Human1.02678101
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02633894
114CTCF_27219007_Chip-Seq_Bcells_Human1.01610537
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.01226634
116AHR_22903824_ChIP-Seq_MCF-7_Human1.01065008
117* SMC4_20622854_ChIP-Seq_HELA_Human1.00667766
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00148334
119SMAD4_21799915_ChIP-Seq_A2780_Human1.00028324
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.99672286
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.98446652
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97741108
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96548726
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96474666
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.94968836
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94527968
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.94101955
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93957074
129CREB1_26743006_Chip-Seq_LNCaP_Human0.92424798
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.91932672
131KLF4_19829295_ChIP-Seq_ESCs_Human0.89260357
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.88297782
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.88076312
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.87732017
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87523969
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87455343
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87042721
138ZNF274_21170338_ChIP-Seq_K562_Hela0.86536637
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86394066
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86357983
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85632827
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82898014
143* STAT3_23295773_ChIP-Seq_U87_Human0.82525873
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81857463
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81469614
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81169019
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.81063635
148AR_25329375_ChIP-Seq_VCAP_Human0.80690226
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.78671250
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78532656
151* SMAD3_21741376_ChIP-Seq_HESCs_Human0.78249849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.65631429
2MP0003635_abnormal_synaptic_transmissio3.91669285
3MP0003705_abnormal_hypodermis_morpholog3.51621285
4MP0002822_catalepsy3.25590505
5MP0004270_analgesia3.24738607
6MP0002063_abnormal_learning/memory/cond2.99709607
7MP0009745_abnormal_behavioral_response2.91724311
8MP0008260_abnormal_autophagy2.88369306
9MP0002064_seizures2.81236156
10MP0003880_abnormal_central_pattern2.80076207
11MP0005423_abnormal_somatic_nervous2.74998024
12MP0009780_abnormal_chondrocyte_physiolo2.70126742
13MP0009046_muscle_twitch2.67463043
14MP0002909_abnormal_adrenal_gland2.61185456
15MP0003436_decreased_susceptibility_to2.50009581
16MP0002572_abnormal_emotion/affect_behav2.37409089
17MP0001968_abnormal_touch/_nociception2.24443820
18MP0008569_lethality_at_weaning2.22650758
19MP0008961_abnormal_basal_metabolism2.22423248
20MP0003724_increased_susceptibility_to2.20115810
21MP0004858_abnormal_nervous_system2.13438526
22MP0002734_abnormal_mechanical_nocicepti2.05704288
23MP0002272_abnormal_nervous_system2.04902645
24MP0001486_abnormal_startle_reflex1.99056448
25MP0001501_abnormal_sleep_pattern1.93613377
26MP0003329_amyloid_beta_deposits1.92646041
27MP0004885_abnormal_endolymph1.88974635
28MP0004811_abnormal_neuron_physiology1.87161711
29MP0010234_abnormal_vibrissa_follicle1.83103286
30MP0000569_abnormal_digit_pigmentation1.73108427
31MP0005409_darkened_coat_color1.71063219
32MP0003091_abnormal_cell_migration1.69200970
33MP0002733_abnormal_thermal_nociception1.67846928
34MP0005451_abnormal_body_composition1.64304467
35MP0009278_abnormal_bone_marrow1.64106797
36MP0003879_abnormal_hair_cell1.60943732
37MP0003633_abnormal_nervous_system1.60204670
38MP0003787_abnormal_imprinting1.60174151
39MP0003566_abnormal_cell_adhesion1.55270488
40MP0002067_abnormal_sensory_capabilities1.55169828
41MP0002557_abnormal_social/conspecific_i1.54763182
42MP0001970_abnormal_pain_threshold1.54629942
43MP0002736_abnormal_nociception_after1.53567068
44MP0001440_abnormal_grooming_behavior1.53504574
45MP0003172_abnormal_lysosome_physiology1.51765450
46MP0002735_abnormal_chemical_nociception1.50465673
47MP0000955_abnormal_spinal_cord1.50440052
48MP0003690_abnormal_glial_cell1.50090850
49MP0001849_ear_inflammation1.48005077
50MP0002184_abnormal_innervation1.45896098
51MP0003045_fibrosis1.44177515
52MP0003075_altered_response_to1.44030823
53MP0004130_abnormal_muscle_cell1.43204556
54MP0001502_abnormal_circadian_rhythm1.41471657
55MP0005386_behavior/neurological_phenoty1.37738159
56MP0004924_abnormal_behavior1.37738159
57MP0009840_abnormal_foam_cell1.36519982
58MP0003283_abnormal_digestive_organ1.33912142
59MP0005646_abnormal_pituitary_gland1.31999351
60MP0000013_abnormal_adipose_tissue1.27668887
61MP0004947_skin_inflammation1.26984851
62MP0000778_abnormal_nervous_system1.25138908
63MP0005167_abnormal_blood-brain_barrier1.25039470
64MP0002882_abnormal_neuron_morphology1.24934746
65MP0004510_myositis1.24843556
66MP0003656_abnormal_erythrocyte_physiolo1.24463264
67MP0003300_gastrointestinal_ulcer1.23892524
68MP0005076_abnormal_cell_differentiation1.23887877
69MP0003631_nervous_system_phenotype1.23321310
70MP0001533_abnormal_skeleton_physiology1.20142483
71MP0002066_abnormal_motor_capabilities/c1.20048907
72MP0001958_emphysema1.18776971
73MP0003453_abnormal_keratinocyte_physiol1.15508969
74MP0008438_abnormal_cutaneous_collagen1.15131907
75MP0008874_decreased_physiological_sensi1.14594302
76MP0001984_abnormal_olfaction1.14548419
77MP0005464_abnormal_platelet_physiology1.10876040
78MP0000604_amyloidosis1.10073107
79MP0002419_abnormal_innate_immunity1.07204936
80MP0005535_abnormal_body_temperature1.06793046
81MP0002229_neurodegeneration1.06235965
82MP0003183_abnormal_peptide_metabolism1.05003680
83MP0001915_intracranial_hemorrhage1.03609150
84MP0002877_abnormal_melanocyte_morpholog1.02439063
85MP0003634_abnormal_glial_cell1.01888320
86MP0003828_pulmonary_edema1.01112385
87MP0003279_aneurysm1.00382687
88MP0005551_abnormal_eye_electrophysiolog0.99815910
89MP0002152_abnormal_brain_morphology0.99296156
90MP0005257_abnormal_intraocular_pressure0.98833676
91MP0002998_abnormal_bone_remodeling0.97084448
92MP0005645_abnormal_hypothalamus_physiol0.96930487
93MP0003303_peritoneal_inflammation0.96371170
94MP0002069_abnormal_eating/drinking_beha0.94494523
95MP0001851_eye_inflammation0.93653859
96MP0003123_paternal_imprinting0.93105883
97MP0002090_abnormal_vision0.92216788
98MP0005000_abnormal_immune_tolerance0.91924159
99MP0003122_maternal_imprinting0.89863517
100MP0000681_abnormal_thyroid_gland0.88075639
101MP0005621_abnormal_cell_physiology0.88004968
102MP0002249_abnormal_larynx_morphology0.86449119
103MP0005025_abnormal_response_to0.84702690
104MP0008872_abnormal_physiological_respon0.83728061
105MP0004085_abnormal_heartbeat0.83273202
106MP0004145_abnormal_muscle_electrophysio0.81651540
107MP0003632_abnormal_nervous_system0.81550808
108MP0005377_hearing/vestibular/ear_phenot0.81385606
109MP0003878_abnormal_ear_physiology0.81385606
110MP0005623_abnormal_meninges_morphology0.80727620
111MP0000751_myopathy0.80041708
112MP0005410_abnormal_fertilization0.78370973
113MP0004233_abnormal_muscle_weight0.75910654
114MP0001177_atelectasis0.75088118
115MP0010386_abnormal_urinary_bladder0.74054269
116MP0005499_abnormal_olfactory_system0.73699001
117MP0005394_taste/olfaction_phenotype0.73699001
118MP0000465_gastrointestinal_hemorrhage0.73261856
119MP0000858_altered_metastatic_potential0.72464445
120MP0000920_abnormal_myelination0.72190117
121MP0000003_abnormal_adipose_tissue0.71312001
122MP0005390_skeleton_phenotype0.68164517
123MP0001765_abnormal_ion_homeostasis0.67371597
124MP0004043_abnormal_pH_regulation0.65730171
125MP0005448_abnormal_energy_balance0.65324428
126* MP0002078_abnormal_glucose_homeostasis0.63472979
127MP0002653_abnormal_ependyma_morphology0.62950825
128MP0009333_abnormal_splenocyte_physiolog0.62775309
129MP0001545_abnormal_hematopoietic_system0.60655636
130MP0005397_hematopoietic_system_phenotyp0.60655636
131MP0002089_abnormal_postnatal_growth/wei0.60424557
132MP0000678_abnormal_parathyroid_gland0.59169447
133MP0005187_abnormal_penis_morphology0.59028374
134MP0001348_abnormal_lacrimal_gland0.57584355
135MP0005166_decreased_susceptibility_to0.56198746
136MP0000747_muscle_weakness0.55703896
137MP0002234_abnormal_pharynx_morphology0.53444642
138MP0005058_abnormal_lysosome_morphology0.51859980
139MP0003191_abnormal_cellular_cholesterol0.50699833
140MP0001299_abnormal_eye_distance/0.50416163
141MP0005375_adipose_tissue_phenotype0.49836002
142MP0002638_abnormal_pupillary_reflex0.49813183
143MP0001944_abnormal_pancreas_morphology0.49726485

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.80635856
2Focal motor seizures (HP:0011153)4.34181176
3Focal seizures (HP:0007359)4.29744779
4Visual hallucinations (HP:0002367)4.23968671
5Supranuclear gaze palsy (HP:0000605)3.63205135
6Insomnia (HP:0100785)3.57674252
7Action tremor (HP:0002345)3.56020894
8Hyperacusis (HP:0010780)3.29655234
9Ankle clonus (HP:0011448)3.21919482
10Depression (HP:0000716)3.17288143
11Abnormality of the lower motor neuron (HP:0002366)3.11870236
12Progressive cerebellar ataxia (HP:0002073)3.10854939
13Epileptic encephalopathy (HP:0200134)3.07118305
14Postural instability (HP:0002172)3.06456110
15Febrile seizures (HP:0002373)3.03490584
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.90116623
17Peripheral hypomyelination (HP:0007182)2.82444917
18Dysmetric saccades (HP:0000641)2.81313966
19Elfin facies (HP:0004428)2.80422261
20Hemiplegia (HP:0002301)2.80306778
21Truncal ataxia (HP:0002078)2.79795562
22Abnormal social behavior (HP:0012433)2.79134605
23Impaired social interactions (HP:0000735)2.79134605
24Papilledema (HP:0001085)2.78155265
25Impaired vibration sensation in the lower limbs (HP:0002166)2.73459626
26Eczematoid dermatitis (HP:0000976)2.72203708
27Generalized tonic-clonic seizures (HP:0002069)2.71641187
28Atonic seizures (HP:0010819)2.71111902
29Urinary bladder sphincter dysfunction (HP:0002839)2.70736207
30Poor eye contact (HP:0000817)2.68608156
31Macroorchidism (HP:0000053)2.64673683
32Apathy (HP:0000741)2.63426230
33Impaired smooth pursuit (HP:0007772)2.60877971
34Pointed chin (HP:0000307)2.53923245
35Absence seizures (HP:0002121)2.49368351
36Diminished motivation (HP:0000745)2.47885358
37Urinary urgency (HP:0000012)2.45834581
38Intention tremor (HP:0002080)2.45730722
39Abnormality of ocular smooth pursuit (HP:0000617)2.41990563
40Dysdiadochokinesis (HP:0002075)2.39935203
41Hemiparesis (HP:0001269)2.39021969
42Renovascular hypertension (HP:0100817)2.38206003
43Spontaneous hematomas (HP:0007420)2.38048073
44Neoplasm of the heart (HP:0100544)2.37904873
45Genetic anticipation (HP:0003743)2.37893009
46Slow saccadic eye movements (HP:0000514)2.35322560
47Abnormality of binocular vision (HP:0011514)2.33652282
48Diplopia (HP:0000651)2.33652282
49Torticollis (HP:0000473)2.32234427
50Overriding aorta (HP:0002623)2.30923033
51Spastic gait (HP:0002064)2.29482486
52Cerebral inclusion bodies (HP:0100314)2.27597283
53Dialeptic seizures (HP:0011146)2.26252557
54Upper motor neuron abnormality (HP:0002127)2.26121408
55Mutism (HP:0002300)2.26051685
56Dysmetria (HP:0001310)2.23833061
57Neuronal loss in central nervous system (HP:0002529)2.23209555
58Gaze-evoked nystagmus (HP:0000640)2.22843860
59Ventricular fibrillation (HP:0001663)2.22239087
60Cellulitis (HP:0100658)2.19158045
61Resting tremor (HP:0002322)2.18231120
62Vertebral compression fractures (HP:0002953)2.15694389
63Decreased motor nerve conduction velocity (HP:0003431)2.14691181
64Anxiety (HP:0000739)2.13663974
65Bradykinesia (HP:0002067)2.12650964
66Hyperparathyroidism (HP:0000843)2.12563688
67Status epilepticus (HP:0002133)2.10916260
68Neurofibrillary tangles (HP:0002185)2.10739307
69Shallow orbits (HP:0000586)2.10624779
70Lower limb muscle weakness (HP:0007340)2.09215234
71Megalencephaly (HP:0001355)2.08847574
72Abnormal eating behavior (HP:0100738)2.08776482
73Protrusio acetabuli (HP:0003179)2.07147352
74Achilles tendon contracture (HP:0001771)2.06300078
75Stereotypic behavior (HP:0000733)2.06076271
76Annular pancreas (HP:0001734)2.05417682
77Increased variability in muscle fiber diameter (HP:0003557)2.04184412
78Bundle branch block (HP:0011710)2.04139551
79Growth hormone excess (HP:0000845)2.03819421
80Hypercortisolism (HP:0001578)2.03468157
81Tetraplegia (HP:0002445)2.01183506
82Focal dystonia (HP:0004373)1.99990841
83Interstitial pulmonary disease (HP:0006530)1.99898717
84Broad-based gait (HP:0002136)1.98862540
85Cerebral aneurysm (HP:0004944)1.98068666
86Onion bulb formation (HP:0003383)1.97144444
87Renal duplication (HP:0000075)1.97061510
88Amblyopia (HP:0000646)1.95767278
89Hammertoe (HP:0001765)1.95054866
90Segmental peripheral demyelination/remyelination (HP:0003481)1.94911027
91Spinal canal stenosis (HP:0003416)1.94876544
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94777167
93Vertebral arch anomaly (HP:0008438)1.94276180
94Disproportionate tall stature (HP:0001519)1.93888248
95Heterotopia (HP:0002282)1.93694689
96Long palpebral fissure (HP:0000637)1.92986365
97Upper limb amyotrophy (HP:0009129)1.92681862
98Distal upper limb amyotrophy (HP:0007149)1.92681862
99Lower limb amyotrophy (HP:0007210)1.92038733
100Loss of speech (HP:0002371)1.91227261
101Distal sensory impairment (HP:0002936)1.91175445
102Rapidly progressive (HP:0003678)1.89555422
103Ulnar bowing (HP:0003031)1.89056342
104Recurrent abscess formation (HP:0002722)1.87472882
105Gingivitis (HP:0000230)1.87363541
106Impaired vibratory sensation (HP:0002495)1.86971941
107Clonus (HP:0002169)1.86686140
108Obstructive sleep apnea (HP:0002870)1.86213966
109Polygenic inheritance (HP:0010982)1.84762687
110Broad distal phalanx of finger (HP:0009836)1.83729715
111Craniofacial dystonia (HP:0012179)1.82300316
112Abnormality of saccadic eye movements (HP:0000570)1.82178123
113Agitation (HP:0000713)1.81721151
114Ankyloglossia (HP:0010296)1.81423657
115Flat cornea (HP:0007720)1.80963792
116Mitral regurgitation (HP:0001653)1.79712709
117Excessive salivation (HP:0003781)1.79424325
118Drooling (HP:0002307)1.79424325
119Bowel incontinence (HP:0002607)1.78932547
120Hand muscle atrophy (HP:0009130)1.78640394
121Bowel diverticulosis (HP:0005222)1.76881660
122Abnormality of the corticospinal tract (HP:0002492)1.76461697
123Scanning speech (HP:0002168)1.76035638
124Abnormality of the Achilles tendon (HP:0005109)1.75934969
125Hypsarrhythmia (HP:0002521)1.74997695
126Premature rupture of membranes (HP:0001788)1.74511192
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.74144762
128Abnormality of macrophages (HP:0004311)1.74139216
129Progressive inability to walk (HP:0002505)1.73908950
130EEG with generalized epileptiform discharges (HP:0011198)1.73904204
131Foot dorsiflexor weakness (HP:0009027)1.72577144
132Striae distensae (HP:0001065)1.72279516
133Termporal pattern (HP:0011008)1.72184589
134Insidious onset (HP:0003587)1.72184589
135Abnormal gallbladder physiology (HP:0012438)1.72143986
136Cholecystitis (HP:0001082)1.72143986
137Rigidity (HP:0002063)1.71974078
138Epileptiform EEG discharges (HP:0011182)1.71868314
139Difficulty climbing stairs (HP:0003551)1.70141189
140Increased connective tissue (HP:0009025)1.69802139
141Recurrent bacterial skin infections (HP:0005406)1.69797524
142Abnormality of oral frenula (HP:0000190)1.67861650
143Abnormal large intestine physiology (HP:0012700)1.67767570
144Long toe (HP:0010511)1.67597224
145Distal lower limb amyotrophy (HP:0008944)1.67582677
146Abnormality of liposaccharide metabolism (HP:0010968)1.66669905
147Abnormality of glycosphingolipid metabolism (HP:0004343)1.66669905
148Abnormality of glycolipid metabolism (HP:0010969)1.66669905
149Sleep apnea (HP:0010535)1.64190370
150Spinal cord lesions (HP:0100561)1.63232448
151Syringomyelia (HP:0003396)1.63232448
152Abnormality of skeletal muscle fiber size (HP:0012084)1.62811981
153Thin bony cortex (HP:0002753)1.60913127
154Increased IgE level (HP:0003212)1.60364284
155Genu recurvatum (HP:0002816)1.60331486
156Delusions (HP:0000746)1.59884337
157Dilatation of the ascending aorta (HP:0005111)1.59680497
158Arnold-Chiari malformation (HP:0002308)1.59269756
159Ocular albinism (HP:0001107)1.58916214
160Purpura (HP:0000979)1.57759186
161Reticulocytosis (HP:0001923)1.56929733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.54069777
2NTRK33.38253655
3EPHA42.84635538
4PRKD32.50184490
5MARK12.39503546
6TRIB32.34929000
7SMG12.34314237
8DAPK22.28792795
9ERN12.21494005
10KSR22.17510298
11SIK22.09291147
12CAMKK12.07596579
13MAP3K112.06101390
14MAP3K42.03689572
15MAP2K32.00638897
16NTRK21.99507855
17PAK61.91228478
18MINK11.90081199
19EPHB11.75712496
20EEF2K1.67674289
21NTRK11.62481591
22STK381.60647455
23TAOK21.59931519
24PKN21.58713353
25RIPK11.53000359
26MAP3K31.49123818
27PRKCH1.47643195
28MAP3K21.46229529
29RET1.42899438
30CDK121.41370057
31SGK31.40168786
32TYRO31.40029268
33IRAK31.34191717
34LATS21.33678102
35MAP2K41.32721676
36CDK51.29590405
37LMTK21.28260802
38MAP3K61.27217049
39MAP3K71.24793142
40RIPK41.23823559
41TAOK11.20070307
42MAP3K131.20035699
43FES1.16093778
44GRK51.15113381
45SGK21.11260696
46MARK21.10949758
47CAMK1G1.10685454
48ALK1.09831102
49SGK4941.09790416
50SGK2231.09790416
51TESK21.09077517
52MAP2K71.07869277
53ICK1.06652000
54PDGFRA1.06565624
55PDK11.03963037
56KSR11.03664311
57PTK61.03598075
58IRAK20.95425526
59DAPK10.92293994
60UHMK10.91173751
61TESK10.89322075
62STK110.88879182
63JAK10.88350384
64PHKG10.85905390
65PHKG20.85905390
66IRAK40.85171045
67ZAP700.84686926
68MAP3K10.84121734
69CAMK10.83105992
70FGFR20.82927215
71MAP4K10.82503478
72EPHA30.82289775
73PDPK10.81124633
74MAP3K100.81085205
75SIK30.79070997
76WNK10.78319965
77CDC42BPA0.77544705
78TNK20.77268259
79CAMKK20.75791323
80PTK2B0.75317591
81PRPF4B0.74432348
82PRKCG0.74141911
83BRAF0.72417665
84MAPK130.70233923
85PIM20.70158026
86RPS6KA20.69583695
87JAK20.69546709
88SCYL20.69183551
89SIK10.68556001
90CAMK40.68508974
91FGFR30.68257954
92MTOR0.66906735
93CSK0.65705996
94RPS6KC10.65471387
95RPS6KL10.65471387
96FGFR40.64257287
97SGK10.63634692
98PDGFRB0.62608956
99HIPK20.59924980
100CDK140.59410950
101FYN0.59048479
102FGR0.58928292
103TTN0.58325740
104PAK30.56600631
105ARAF0.55696855
106HCK0.54853725
107PRKCZ0.54550170
108PINK10.53794966
109CAMK1D0.52748787
110TGFBR20.52412006
111RPS6KA30.52357698
112LRRK20.52034588
113TYK20.51573320
114PRKD20.50723817
115NEK60.50107700
116JAK30.48560471
117MAP3K50.47906320
118CDK150.46719634
119MAPK120.46361224
120DYRK1A0.46063849
121BMX0.45817315
122PRKD10.44608670
123RAF10.44556632
124TNIK0.44025217
125CDK180.42039510
126PRKAA10.41537434
127PTK20.41209966
128GRK60.41150569
129DMPK0.41003238
130MAPK100.40435309
131DYRK1B0.37996865
132MAPK80.37302522
133CDK11A0.37167953

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.40543880
2Olfactory transduction_Homo sapiens_hsa047402.38226871
3Circadian entrainment_Homo sapiens_hsa047132.11769029
4Nicotine addiction_Homo sapiens_hsa050332.10441843
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09217423
6Long-term potentiation_Homo sapiens_hsa047202.07158371
7GABAergic synapse_Homo sapiens_hsa047272.03424757
8Glutamatergic synapse_Homo sapiens_hsa047241.93093359
9Nitrogen metabolism_Homo sapiens_hsa009101.89198751
10Insulin secretion_Homo sapiens_hsa049111.89053315
11Morphine addiction_Homo sapiens_hsa050321.88658905
12Amphetamine addiction_Homo sapiens_hsa050311.78705357
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78344827
14Salivary secretion_Homo sapiens_hsa049701.77171292
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74431425
16Gastric acid secretion_Homo sapiens_hsa049711.69567250
17Dopaminergic synapse_Homo sapiens_hsa047281.63676846
18Type II diabetes mellitus_Homo sapiens_hsa049301.59726851
19Cholinergic synapse_Homo sapiens_hsa047251.59640657
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57712713
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55661214
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53067707
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49826246
24Renin secretion_Homo sapiens_hsa049241.47596278
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47034119
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45601595
27Acute myeloid leukemia_Homo sapiens_hsa052211.42174917
28Osteoclast differentiation_Homo sapiens_hsa043801.38900208
29* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34605621
30Notch signaling pathway_Homo sapiens_hsa043301.34385002
31Cocaine addiction_Homo sapiens_hsa050301.34285456
32Oxytocin signaling pathway_Homo sapiens_hsa049211.33697074
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26837768
34Pancreatic cancer_Homo sapiens_hsa052121.25168384
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23691116
36Estrogen signaling pathway_Homo sapiens_hsa049151.22378911
37Taste transduction_Homo sapiens_hsa047421.22328739
38Vibrio cholerae infection_Homo sapiens_hsa051101.20762145
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19630584
40GnRH signaling pathway_Homo sapiens_hsa049121.19563155
41Glioma_Homo sapiens_hsa052141.17932354
42cAMP signaling pathway_Homo sapiens_hsa040241.14453522
43Long-term depression_Homo sapiens_hsa047301.14310262
44Calcium signaling pathway_Homo sapiens_hsa040201.13695508
45Dorso-ventral axis formation_Homo sapiens_hsa043201.13225744
46Gap junction_Homo sapiens_hsa045401.07674976
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07328103
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04496190
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02134594
50Other glycan degradation_Homo sapiens_hsa005111.01557305
51Salmonella infection_Homo sapiens_hsa051321.01121986
52Tuberculosis_Homo sapiens_hsa051520.99382630
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97402347
54Pancreatic secretion_Homo sapiens_hsa049720.94902849
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.94572683
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94383259
57Shigellosis_Homo sapiens_hsa051310.93592200
58Bile secretion_Homo sapiens_hsa049760.92993186
59ErbB signaling pathway_Homo sapiens_hsa040120.92771687
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.92487571
61mTOR signaling pathway_Homo sapiens_hsa041500.91234075
62Serotonergic synapse_Homo sapiens_hsa047260.89609266
63Phototransduction_Homo sapiens_hsa047440.87431189
64Bladder cancer_Homo sapiens_hsa052190.85565755
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.85390081
66Endometrial cancer_Homo sapiens_hsa052130.85164479
67Amoebiasis_Homo sapiens_hsa051460.84845429
68Phagosome_Homo sapiens_hsa041450.84057821
69Hepatitis B_Homo sapiens_hsa051610.83758329
70Thyroid hormone synthesis_Homo sapiens_hsa049180.82052730
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.81928906
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81675581
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81583148
74Non-small cell lung cancer_Homo sapiens_hsa052230.81327240
75Glucagon signaling pathway_Homo sapiens_hsa049220.80502832
76Leishmaniasis_Homo sapiens_hsa051400.78805503
77VEGF signaling pathway_Homo sapiens_hsa043700.78486926
78Melanogenesis_Homo sapiens_hsa049160.78419378
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.77559025
80Inositol phosphate metabolism_Homo sapiens_hsa005620.77450591
81Hepatitis C_Homo sapiens_hsa051600.75450649
82Malaria_Homo sapiens_hsa051440.73507066
83Toxoplasmosis_Homo sapiens_hsa051450.73440092
84Axon guidance_Homo sapiens_hsa043600.73237357
85Choline metabolism in cancer_Homo sapiens_hsa052310.72342027
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71974475
87Endocytosis_Homo sapiens_hsa041440.71634098
88Insulin signaling pathway_Homo sapiens_hsa049100.71274500
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70439472
90MAPK signaling pathway_Homo sapiens_hsa040100.69263432
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67673665
92TNF signaling pathway_Homo sapiens_hsa046680.66839611
93Apoptosis_Homo sapiens_hsa042100.66796008
94Focal adhesion_Homo sapiens_hsa045100.65254658
95Insulin resistance_Homo sapiens_hsa049310.64804102
96Chemokine signaling pathway_Homo sapiens_hsa040620.64391087
97Dilated cardiomyopathy_Homo sapiens_hsa054140.64201470
98HIF-1 signaling pathway_Homo sapiens_hsa040660.62413815
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61672699
100Prolactin signaling pathway_Homo sapiens_hsa049170.59994785
101Collecting duct acid secretion_Homo sapiens_hsa049660.59854926
102Chronic myeloid leukemia_Homo sapiens_hsa052200.58995148
103Lysosome_Homo sapiens_hsa041420.58786717
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58679432
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57980528
106Influenza A_Homo sapiens_hsa051640.57737865
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56556257
108B cell receptor signaling pathway_Homo sapiens_hsa046620.55887012
109Platelet activation_Homo sapiens_hsa046110.55220403
110Rap1 signaling pathway_Homo sapiens_hsa040150.55204625
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53757905
112Prion diseases_Homo sapiens_hsa050200.53301087
113Renal cell carcinoma_Homo sapiens_hsa052110.51162355
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.48989249
115Arginine biosynthesis_Homo sapiens_hsa002200.47522442
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46467886
117Ras signaling pathway_Homo sapiens_hsa040140.45493813
118Fatty acid biosynthesis_Homo sapiens_hsa000610.45386102
119T cell receptor signaling pathway_Homo sapiens_hsa046600.45125679
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.45023008
121Alcoholism_Homo sapiens_hsa050340.44149298
122AMPK signaling pathway_Homo sapiens_hsa041520.42939977
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42268521
124Type I diabetes mellitus_Homo sapiens_hsa049400.42026176
125Colorectal cancer_Homo sapiens_hsa052100.41495127
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40935315
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40699277
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40236200
129ABC transporters_Homo sapiens_hsa020100.40233079
130Circadian rhythm_Homo sapiens_hsa047100.38961366

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