IP6K2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83149777
2presynaptic membrane assembly (GO:0097105)4.64108615
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47953169
4COPI coating of Golgi vesicle (GO:0048205)4.11814920
5Golgi transport vesicle coating (GO:0048200)4.11814920
6response to pheromone (GO:0019236)4.10285332
7synaptic vesicle maturation (GO:0016188)4.10118601
8sequestering of actin monomers (GO:0042989)4.05905395
9presynaptic membrane organization (GO:0097090)4.03018411
10pyrimidine nucleobase catabolic process (GO:0006208)3.98968675
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.65733969
12regulation of rhodopsin mediated signaling pathway (GO:0022400)3.65545184
13rhodopsin mediated signaling pathway (GO:0016056)3.62029193
14limb bud formation (GO:0060174)3.61900388
15locomotory exploration behavior (GO:0035641)3.61704588
16layer formation in cerebral cortex (GO:0021819)3.58304187
17regulation of synaptic vesicle exocytosis (GO:2000300)3.56853952
18regulation of cilium movement (GO:0003352)3.53268940
19synaptic vesicle exocytosis (GO:0016079)3.44909548
20nonmotile primary cilium assembly (GO:0035058)3.44104920
21protein polyglutamylation (GO:0018095)3.43997830
22positive regulation of mitochondrial fission (GO:0090141)3.40198693
23intraciliary transport (GO:0042073)3.37303589
24photoreceptor cell development (GO:0042461)3.35975272
25protein localization to synapse (GO:0035418)3.33596886
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32191258
27dendrite morphogenesis (GO:0048813)3.31585248
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30975164
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29706811
30protein localization to cilium (GO:0061512)3.29452081
31DNA integration (GO:0015074)3.29065022
32glutamate secretion (GO:0014047)3.23929587
33DNA damage response, detection of DNA damage (GO:0042769)3.23708430
34regulation of development, heterochronic (GO:0040034)3.21179677
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21015472
36somite development (GO:0061053)3.20977371
37cell migration in hindbrain (GO:0021535)3.19882935
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15436781
39regulation of synaptic vesicle transport (GO:1902803)3.15226806
40pyrimidine dimer repair (GO:0006290)3.13820301
41regulation of glutamate receptor signaling pathway (GO:1900449)3.12895870
42neurotransmitter secretion (GO:0007269)3.12416751
43eye photoreceptor cell development (GO:0042462)3.11156103
44synapse assembly (GO:0007416)3.09872600
45regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.08512601
46histone H2A acetylation (GO:0043968)3.08361604
47epithelial cilium movement (GO:0003351)3.03124715
48cerebellar Purkinje cell layer development (GO:0021680)2.99790364
49cell communication by electrical coupling (GO:0010644)2.99257117
50axonal fasciculation (GO:0007413)2.99000703
51retinal cone cell development (GO:0046549)2.98659730
52nucleobase catabolic process (GO:0046113)2.95777884
53cullin deneddylation (GO:0010388)2.95769469
54regulation of timing of cell differentiation (GO:0048505)2.94613244
55vocalization behavior (GO:0071625)2.93992568
56regulation of synapse structural plasticity (GO:0051823)2.93832855
57dendritic spine morphogenesis (GO:0060997)2.93454544
58activation of protein kinase A activity (GO:0034199)2.93400286
59innervation (GO:0060384)2.91703398
60establishment of mitochondrion localization (GO:0051654)2.88856315
61neuron recognition (GO:0008038)2.88736927
62calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85844299
63protein-cofactor linkage (GO:0018065)2.85736831
64cellular response to glucagon stimulus (GO:0071377)2.82208936
65insulin secretion (GO:0030073)2.81241842
66photoreceptor cell maintenance (GO:0045494)2.80856716
67regulation of neuronal synaptic plasticity (GO:0048168)2.79604356
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79270468
69endocrine pancreas development (GO:0031018)2.79101672
70negative regulation of response to food (GO:0032096)2.78946718
71negative regulation of appetite (GO:0032099)2.78946718
72retinal ganglion cell axon guidance (GO:0031290)2.78076477
73exploration behavior (GO:0035640)2.78008159
74auditory behavior (GO:0031223)2.77604751
75macroautophagy (GO:0016236)2.77548294
76olfactory bulb development (GO:0021772)2.77422276
77protein complex biogenesis (GO:0070271)2.77186628
78neurofilament cytoskeleton organization (GO:0060052)2.76175553
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75634481
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.74718729
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73875175
82dopamine receptor signaling pathway (GO:0007212)2.73116393
83regulation of microtubule-based movement (GO:0060632)2.71188918
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69769367
85phototransduction (GO:0007602)2.69277522
86cerebellum development (GO:0021549)2.69192388
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68249571
88protein deneddylation (GO:0000338)2.68097163
89neuron cell-cell adhesion (GO:0007158)2.66333315
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65915621
91short-term memory (GO:0007614)2.64656162
92neural tube formation (GO:0001841)2.62323460
93negative regulation of heart rate (GO:0010459)2.61542054
94behavioral response to nicotine (GO:0035095)2.61278801
95DNA double-strand break processing (GO:0000729)2.60152432
96phototransduction, visible light (GO:0007603)2.59429717
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58977666
98cilium morphogenesis (GO:0060271)2.58720284
99glycosphingolipid biosynthetic process (GO:0006688)2.58430490
100head development (GO:0060322)2.58122516
101proline transport (GO:0015824)2.57348441
102membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57293695
103NADH dehydrogenase complex assembly (GO:0010257)2.56728239
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56728239
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.56728239
106central nervous system projection neuron axonogenesis (GO:0021952)2.56557987
107negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56367187
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.55925562
109chemosensory behavior (GO:0007635)2.55902265
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55793029
111postsynaptic membrane organization (GO:0001941)2.55666472
112axoneme assembly (GO:0035082)2.54422182
113spinal cord development (GO:0021510)2.54330774
114cilium assembly (GO:0042384)2.53532563
115protein-chromophore linkage (GO:0018298)2.53240021
116detection of light stimulus (GO:0009583)2.52650360
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.52077073
118neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.51701630
119hippocampus development (GO:0021766)2.51451698
120cilium organization (GO:0044782)2.51267290
121vesicle coating (GO:0006901)2.51118146
122positive regulation of synapse maturation (GO:0090129)2.50276815
123positive regulation of guanylate cyclase activity (GO:0031284)2.49612136
124cerebellar Purkinje cell differentiation (GO:0021702)2.49530642
125mitochondrial respiratory chain complex assembly (GO:0033108)2.49353194
126regulation of feeding behavior (GO:0060259)2.48825372
127mating behavior (GO:0007617)2.48638089
128detection of visible light (GO:0009584)2.48222603
129synaptic vesicle endocytosis (GO:0048488)2.47988554
130protein retention in ER lumen (GO:0006621)2.46656315
131neurotransmitter transport (GO:0006836)2.46423757
132synaptic transmission, glutamatergic (GO:0035249)2.46339667
133regulation of autophagic vacuole assembly (GO:2000785)2.45572229
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.43906845
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43906845
136lactate metabolic process (GO:0006089)2.43670364
137protein neddylation (GO:0045116)2.43569813
138cilium movement (GO:0003341)2.43259552
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42841033
140preassembly of GPI anchor in ER membrane (GO:0016254)2.42830629
141membrane repolarization during action potential (GO:0086011)2.42641215
142positive regulation of synapse assembly (GO:0051965)2.41194745
143respiratory chain complex IV assembly (GO:0008535)2.40801329
144ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40619028
145regulation of long-term neuronal synaptic plasticity (GO:0048169)2.39944107
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.39720896
147neurotransmitter-gated ion channel clustering (GO:0072578)2.39353495
148regulation of mRNA splicing, via spliceosome (GO:0048024)2.39180077
149positive regulation of exocytosis (GO:0045921)2.39139417
150glial cell proliferation (GO:0014009)2.38383249
151stress granule assembly (GO:0034063)2.37497448
152inner ear receptor cell development (GO:0060119)2.36980305
153detection of calcium ion (GO:0005513)2.36491046
154regulation of insulin secretion (GO:0050796)2.35734207
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.35377315
156mannosylation (GO:0097502)2.34818236
157neuron fate determination (GO:0048664)2.34545854
158transmission of nerve impulse (GO:0019226)2.34488580
159positive regulation of insulin secretion (GO:0032024)2.34007212
160alanine transport (GO:0032328)2.33965668
161membrane hyperpolarization (GO:0060081)2.33692572
162negative regulation of telomere maintenance (GO:0032205)2.32906670
163positive regulation of vesicle fusion (GO:0031340)2.32591898
164ATP synthesis coupled proton transport (GO:0015986)2.32397748
165energy coupled proton transport, down electrochemical gradient (GO:0015985)2.32397748
166nitric oxide mediated signal transduction (GO:0007263)2.32075902
167tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.32051204
168RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.32051204
169retinal rod cell development (GO:0046548)2.31205295
170gamma-aminobutyric acid transport (GO:0015812)2.30993795
171nephron epithelium morphogenesis (GO:0072088)2.30123794
172nephron tubule morphogenesis (GO:0072078)2.30123794
173glandular epithelial cell differentiation (GO:0002067)2.29186482
174positive regulation of membrane potential (GO:0045838)2.29152628
175mechanosensory behavior (GO:0007638)2.29134068
176regulation of neurotransmitter secretion (GO:0046928)2.28803628
177negative regulation of oligodendrocyte differentiation (GO:0048715)2.27719969
178anterograde synaptic vesicle transport (GO:0048490)2.27559501
179establishment of protein localization to mitochondrial membrane (GO:0090151)2.25448751
180GPI anchor metabolic process (GO:0006505)2.25208326
181behavioral response to ethanol (GO:0048149)2.23502728
182hindbrain development (GO:0030902)2.22560565
183anterograde axon cargo transport (GO:0008089)2.21399472
184limb development (GO:0060173)2.19883411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66705337
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36250220
3IGF1R_20145208_ChIP-Seq_DFB_Human3.19738146
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87733894
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87395928
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.64355283
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63853700
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.58317169
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57253937
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55712226
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51126969
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49465779
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.49069734
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47835525
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46398924
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46398924
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41140544
18REST_21632747_ChIP-Seq_MESCs_Mouse2.38639910
19* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.31612890
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29958870
21VDR_22108803_ChIP-Seq_LS180_Human2.29762906
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29133538
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28421428
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26747034
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.24066557
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24012114
27GBX2_23144817_ChIP-Seq_PC3_Human2.22862275
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20422003
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17081738
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15398727
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14835391
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13410988
33DROSHA_22980978_ChIP-Seq_HELA_Human2.12174738
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.11594060
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.09350183
36REST_18959480_ChIP-ChIP_MESCs_Mouse2.07867728
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05563413
38POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02954189
39FUS_26573619_Chip-Seq_HEK293_Human1.99380059
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.91807324
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.91336229
42TAF15_26573619_Chip-Seq_HEK293_Human1.88284066
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88093753
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86188208
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85265355
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83738377
47EWS_26573619_Chip-Seq_HEK293_Human1.82776883
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81772121
49IRF1_19129219_ChIP-ChIP_H3396_Human1.79664414
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.77510470
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74693557
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63964630
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.59115594
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.52791886
55KDM2B_26808549_Chip-Seq_K562_Human1.51768634
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50750397
57P300_19829295_ChIP-Seq_ESCs_Human1.50699796
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.50569050
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50375719
60VDR_23849224_ChIP-Seq_CD4+_Human1.47522850
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45981949
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45665787
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.44915452
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43773102
65MYC_18940864_ChIP-ChIP_HL60_Human1.43476655
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42995515
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41677397
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.41487509
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40600411
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37509861
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36422969
72ELK1_19687146_ChIP-ChIP_HELA_Human1.35076868
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34563542
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33001558
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32811658
76GABP_19822575_ChIP-Seq_HepG2_Human1.32217015
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31150162
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30973603
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30479465
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.28644528
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.25846294
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25419857
83AR_19668381_ChIP-Seq_PC3_Human1.24700754
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24561810
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23464527
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23085069
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22983733
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22229900
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18716312
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18583874
91ZNF274_21170338_ChIP-Seq_K562_Hela1.15777245
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15150539
93* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15048182
94FOXP3_21729870_ChIP-Seq_TREG_Human1.14385130
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14199218
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13599301
97CTCF_27219007_Chip-Seq_Bcells_Human1.13073824
98TP53_22573176_ChIP-Seq_HFKS_Human1.12739712
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.12315874
100AR_21572438_ChIP-Seq_LNCaP_Human1.11916023
101CBP_20019798_ChIP-Seq_JUKART_Human1.10633530
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10633530
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10390015
104SMAD4_21799915_ChIP-Seq_A2780_Human1.10289029
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.10181999
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09872161
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09517609
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09068188
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08451420
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07997329
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07250571
112ISL1_27105846_Chip-Seq_CPCs_Mouse1.06857962
113CIITA_25753668_ChIP-Seq_RAJI_Human1.06639177
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06031050
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05580757
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05294779
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03836635
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.02406729
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02319587
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.01711068
121RNF2_27304074_Chip-Seq_NSC_Mouse1.01378875
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.99704787
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.99418007
124AR_25329375_ChIP-Seq_VCAP_Human0.99244878
125TTF2_22483619_ChIP-Seq_HELA_Human0.98285110
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98096342
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.97139217
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.97025423
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96183060
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96033751
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.95424910
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95296171
133AHR_22903824_ChIP-Seq_MCF-7_Human0.95228315
134STAT3_23295773_ChIP-Seq_U87_Human0.94964820
135LXR_22292898_ChIP-Seq_THP-1_Human0.94657340
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94586581
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93945819
138CREB1_26743006_Chip-Seq_LNCaP_Human0.93574450
139HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93251559
140ER_23166858_ChIP-Seq_MCF-7_Human0.93054378
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92434823
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92320689
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92092651
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92008133
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90547705
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89882538
147* XRN2_22483619_ChIP-Seq_HELA_Human0.89164122
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89054314
149BCAT_22108803_ChIP-Seq_LS180_Human0.88725553
150SOX9_26525672_Chip-Seq_HEART_Mouse0.88234223
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87620634
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87318391
153DCP1A_22483619_ChIP-Seq_HELA_Human0.87045657
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86953057
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86868149
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86868149
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.86670160
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86434040
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85898737
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85335853
161FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85041663
162ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84369729
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83113917
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.82365497
165* SMC4_20622854_ChIP-Seq_HELA_Human0.82337628
166NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80866741
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80604567
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80572051
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80397448
170SMAD3_21741376_ChIP-Seq_EPCs_Human0.80153185
171MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78664308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.64417603
2MP0005551_abnormal_eye_electrophysiolog3.01565338
3MP0002102_abnormal_ear_morphology2.82705058
4MP0006072_abnormal_retinal_apoptosis2.80452897
5MP0009780_abnormal_chondrocyte_physiolo2.80342247
6MP0003283_abnormal_digestive_organ2.55893101
7MP0002909_abnormal_adrenal_gland2.55178406
8MP0001984_abnormal_olfaction2.44926897
9MP0003635_abnormal_synaptic_transmissio2.41739076
10MP0004270_analgesia2.40747251
11MP0001529_abnormal_vocalization2.35143080
12MP0005253_abnormal_eye_physiology2.33707180
13MP0002638_abnormal_pupillary_reflex2.30996127
14MP0008877_abnormal_DNA_methylation2.27370671
15MP0005423_abnormal_somatic_nervous2.26552644
16MP0003011_delayed_dark_adaptation2.17421866
17MP0002653_abnormal_ependyma_morphology2.11220378
18MP0003122_maternal_imprinting2.04315256
19MP0002063_abnormal_learning/memory/cond2.02771410
20MP0008961_abnormal_basal_metabolism1.90498022
21MP0005645_abnormal_hypothalamus_physiol1.89795794
22MP0008995_early_reproductive_senescence1.85116369
23MP0000778_abnormal_nervous_system1.84056431
24MP0001188_hyperpigmentation1.82806191
25MP0004043_abnormal_pH_regulation1.81469691
26MP0002736_abnormal_nociception_after1.79600696
27MP0001502_abnormal_circadian_rhythm1.78155343
28MP0002184_abnormal_innervation1.76895380
29MP0001944_abnormal_pancreas_morphology1.72731092
30MP0004133_heterotaxia1.71118607
31MP0005394_taste/olfaction_phenotype1.70712138
32MP0005499_abnormal_olfactory_system1.70712138
33MP0003787_abnormal_imprinting1.69068993
34MP0004885_abnormal_endolymph1.64248992
35MP0000013_abnormal_adipose_tissue1.63676338
36MP0002572_abnormal_emotion/affect_behav1.60995184
37MP0005646_abnormal_pituitary_gland1.60427508
38MP0005187_abnormal_penis_morphology1.60259565
39MP0002557_abnormal_social/conspecific_i1.59492162
40MP0000566_synostosis1.59156361
41MP0000049_abnormal_middle_ear1.58644682
42MP0010386_abnormal_urinary_bladder1.54379996
43MP0009745_abnormal_behavioral_response1.52735513
44MP0002734_abnormal_mechanical_nocicepti1.52683348
45MP0008789_abnormal_olfactory_epithelium1.52239108
46MP0003938_abnormal_ear_development1.52060234
47MP0002735_abnormal_chemical_nociception1.50927709
48MP0000678_abnormal_parathyroid_gland1.48675302
49MP0002882_abnormal_neuron_morphology1.48083141
50MP0003880_abnormal_central_pattern1.47497020
51MP0006276_abnormal_autonomic_nervous1.45864916
52MP0002064_seizures1.45088888
53MP0000631_abnormal_neuroendocrine_gland1.44832749
54MP0000955_abnormal_spinal_cord1.43351703
55MP0004858_abnormal_nervous_system1.41553257
56MP0004811_abnormal_neuron_physiology1.37123819
57MP0003119_abnormal_digestive_system1.35192236
58MP0005220_abnormal_exocrine_pancreas1.35121628
59MP0002233_abnormal_nose_morphology1.32992739
60MP0001486_abnormal_startle_reflex1.32486423
61* MP0008058_abnormal_DNA_repair1.31130265
62MP0002877_abnormal_melanocyte_morpholog1.30881591
63MP0003252_abnormal_bile_duct1.28757778
64MP0005195_abnormal_posterior_eye1.28154810
65MP0002938_white_spotting1.27600717
66MP0005084_abnormal_gallbladder_morpholo1.24424192
67MP0002733_abnormal_thermal_nociception1.23372440
68MP0004142_abnormal_muscle_tone1.22839515
69MP0002272_abnormal_nervous_system1.22684275
70MP0000003_abnormal_adipose_tissue1.22583312
71MP0003183_abnormal_peptide_metabolism1.22498435
72MP0002234_abnormal_pharynx_morphology1.22145115
73MP0001293_anophthalmia1.19104591
74MP0001905_abnormal_dopamine_level1.18566375
75MP0002693_abnormal_pancreas_physiology1.18173917
76MP0005365_abnormal_bile_salt1.16721718
77MP0001986_abnormal_taste_sensitivity1.15860042
78MP0002139_abnormal_hepatobiliary_system1.15418459
79MP0002752_abnormal_somatic_nervous1.15398105
80MP0005391_vision/eye_phenotype1.14789486
81MP0001270_distended_abdomen1.13498211
82MP0003890_abnormal_embryonic-extraembry1.12880278
83MP0003942_abnormal_urinary_system1.10939881
84MP0002229_neurodegeneration1.10655586
85MP0002152_abnormal_brain_morphology1.08655059
86MP0006035_abnormal_mitochondrial_morpho1.08543443
87MP0004742_abnormal_vestibular_system1.07721198
88MP0003879_abnormal_hair_cell1.07068267
89MP0005248_abnormal_Harderian_gland1.06356936
90MP0001324_abnormal_eye_pigmentation1.06024169
91MP0002078_abnormal_glucose_homeostasis1.05635441
92MP0003937_abnormal_limbs/digits/tail_de1.04263303
93MP0000026_abnormal_inner_ear1.04031479
94MP0002928_abnormal_bile_duct1.03217180
95MP0002067_abnormal_sensory_capabilities1.02248048
96MP0002069_abnormal_eating/drinking_beha0.98835381
97MP0001968_abnormal_touch/_nociception0.98766285
98MP0002822_catalepsy0.97826446
99MP0001286_abnormal_eye_development0.97474663
100MP0000462_abnormal_digestive_system0.96777262
101MP0005367_renal/urinary_system_phenotyp0.96724464
102MP0000516_abnormal_urinary_system0.96724464
103MP0003868_abnormal_feces_composition0.96537377
104MP0008569_lethality_at_weaning0.96045499
105MP0001970_abnormal_pain_threshold0.95243580
106MP0000647_abnormal_sebaceous_gland0.94385586
107MP0003567_abnormal_fetal_cardiomyocyte0.93830398
108MP0000534_abnormal_ureter_morphology0.93031432
109MP0003121_genomic_imprinting0.91588834
110MP0003755_abnormal_palate_morphology0.91105049
111MP0005386_behavior/neurological_phenoty0.90123480
112MP0004924_abnormal_behavior0.90123480
113MP0003385_abnormal_body_wall0.90062306
114MP0001501_abnormal_sleep_pattern0.90061796
115MP0009046_muscle_twitch0.89843459
116MP0003329_amyloid_beta_deposits0.89804070
117MP0006292_abnormal_olfactory_placode0.89361119
118MP0002751_abnormal_autonomic_nervous0.87937908
119MP0002066_abnormal_motor_capabilities/c0.87446018
120MP0002282_abnormal_trachea_morphology0.87350604
121MP0003861_abnormal_nervous_system0.87209089
122MP0003718_maternal_effect0.85058213
123MP0003953_abnormal_hormone_level0.84174572
124MP0002896_abnormal_bone_mineralization0.83764262
125MP0004233_abnormal_muscle_weight0.83227489
126MP0000537_abnormal_urethra_morphology0.81725180
127MP0002090_abnormal_vision0.81463236
128MP0003698_abnormal_male_reproductive0.80480067
129MP0001485_abnormal_pinna_reflex0.80035333
130MP0001299_abnormal_eye_distance/0.79830645
131MP0001440_abnormal_grooming_behavior0.76033578
132MP0002697_abnormal_eye_size0.75383409
133MP0010030_abnormal_orbit_morphology0.73884377
134MP0002837_dystrophic_cardiac_calcinosis0.72066598

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.16119347
2Bony spicule pigmentary retinopathy (HP:0007737)4.91328831
3Abnormal rod and cone electroretinograms (HP:0008323)4.36629195
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.17903267
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.00224806
6Central scotoma (HP:0000603)3.78033326
7Chorioretinal atrophy (HP:0000533)3.75155842
8Medial flaring of the eyebrow (HP:0010747)3.52721528
9Abnormality of macular pigmentation (HP:0008002)3.37378893
10Pancreatic cysts (HP:0001737)3.17595585
11Type II diabetes mellitus (HP:0005978)3.12837258
12True hermaphroditism (HP:0010459)3.12767172
13Abnormality of the labia minora (HP:0012880)3.08795958
14Scotoma (HP:0000575)3.06928195
15Hypoglycemic seizures (HP:0002173)3.01236972
16Pancreatic fibrosis (HP:0100732)2.98985824
17Hepatoblastoma (HP:0002884)2.97211613
18Hyperinsulinemic hypoglycemia (HP:0000825)2.96421362
19Pigmentary retinal degeneration (HP:0001146)2.92514613
20Split foot (HP:0001839)2.86978988
21Genital tract atresia (HP:0001827)2.81878555
22Visual hallucinations (HP:0002367)2.81603727
23Symptomatic seizures (HP:0011145)2.79099328
24Nephronophthisis (HP:0000090)2.78940497
25Myokymia (HP:0002411)2.77455925
26Agitation (HP:0000713)2.77161861
27Lissencephaly (HP:0001339)2.76111511
28Pendular nystagmus (HP:0012043)2.75328677
29Retinal dysplasia (HP:0007973)2.71295120
30Molar tooth sign on MRI (HP:0002419)2.70466057
31Abnormality of midbrain morphology (HP:0002418)2.70466057
32Acute necrotizing encephalopathy (HP:0006965)2.66122373
33Abnormality of calcium-phosphate metabolism (HP:0100530)2.59913146
34Polyphagia (HP:0002591)2.59570593
35Dyschromatopsia (HP:0007641)2.56791577
36Colon cancer (HP:0003003)2.51751918
37Hyperglycinemia (HP:0002154)2.49649462
38Abnormal mitochondria in muscle tissue (HP:0008316)2.42732824
39Decreased central vision (HP:0007663)2.42661854
40Hepatocellular necrosis (HP:0001404)2.41297899
41Mitochondrial inheritance (HP:0001427)2.41188065
42Retinal atrophy (HP:0001105)2.39728562
43Abolished electroretinogram (ERG) (HP:0000550)2.39077196
44EEG with generalized epileptiform discharges (HP:0011198)2.37860700
45Hypsarrhythmia (HP:0002521)2.36006208
46Insomnia (HP:0100785)2.35466832
47Ketoacidosis (HP:0001993)2.34975069
48Acute encephalopathy (HP:0006846)2.33643258
49Megalencephaly (HP:0001355)2.32826945
50Increased CSF lactate (HP:0002490)2.31404656
51Cortical dysplasia (HP:0002539)2.30146746
52Broad-based gait (HP:0002136)2.30141120
53Intestinal atresia (HP:0011100)2.29685326
54Epileptiform EEG discharges (HP:0011182)2.29004678
55Progressive macrocephaly (HP:0004481)2.27793338
56Vitreoretinal degeneration (HP:0000655)2.26832208
57Hyperventilation (HP:0002883)2.26127154
58Attenuation of retinal blood vessels (HP:0007843)2.25519585
59Poor coordination (HP:0002370)2.23748105
60Occipital encephalocele (HP:0002085)2.23254921
61Amyotrophic lateral sclerosis (HP:0007354)2.23058149
62Abnormality of the renal medulla (HP:0100957)2.22246438
63Posterior subcapsular cataract (HP:0007787)2.21065101
64Failure to thrive in infancy (HP:0001531)2.20092152
65Pachygyria (HP:0001302)2.17778533
66Focal motor seizures (HP:0011153)2.17329142
67Hepatic necrosis (HP:0002605)2.17108156
68Specific learning disability (HP:0001328)2.17003396
69Abnormal pancreas size (HP:0012094)2.14613315
70Epileptic encephalopathy (HP:0200134)2.14482007
71Decreased testicular size (HP:0008734)2.12014418
72Retinitis pigmentosa (HP:0000510)2.11180921
73Ankle clonus (HP:0011448)2.10814254
74Depression (HP:0000716)2.09874500
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.09605786
76Hyperglycemia (HP:0003074)2.09249508
77Elfin facies (HP:0004428)2.09195194
78Focal seizures (HP:0007359)2.08980485
79Renal hypoplasia (HP:0000089)2.08687641
80Postaxial hand polydactyly (HP:0001162)2.08228521
81Absent speech (HP:0001344)2.06653400
82Photophobia (HP:0000613)2.05974288
83Poor suck (HP:0002033)2.05690554
84Cerebral hypomyelination (HP:0006808)2.05557794
85Gait imbalance (HP:0002141)2.04672972
86Methylmalonic acidemia (HP:0002912)2.04553807
87Optic nerve hypoplasia (HP:0000609)2.04407679
88Turricephaly (HP:0000262)2.04005672
89Cystic liver disease (HP:0006706)2.03590038
90Hyperacusis (HP:0010780)2.03534858
91Renal duplication (HP:0000075)2.03080980
92Limb dystonia (HP:0002451)2.02643686
93Narrow forehead (HP:0000341)2.01194648
94Type II lissencephaly (HP:0007260)2.00722406
95Supranuclear gaze palsy (HP:0000605)2.00571820
96Abnormality of endocrine pancreas physiology (HP:0012093)2.00431765
97Abnormality of the pancreatic islet cells (HP:0006476)2.00431765
98Progressive cerebellar ataxia (HP:0002073)2.00183106
99Decreased circulating renin level (HP:0003351)1.99084301
100Abnormality of the lower motor neuron (HP:0002366)1.98461350
101Thyroid-stimulating hormone excess (HP:0002925)1.97657625
102Broad foot (HP:0001769)1.97287398
103Anencephaly (HP:0002323)1.97160431
104Neoplasm of the heart (HP:0100544)1.96685524
105Abnormal biliary tract physiology (HP:0012439)1.96561276
106Bile duct proliferation (HP:0001408)1.96561276
107Hypothermia (HP:0002045)1.96495907
108Sclerocornea (HP:0000647)1.96098458
109Postaxial foot polydactyly (HP:0001830)1.94583873
110CNS hypomyelination (HP:0003429)1.94084379
111Preaxial hand polydactyly (HP:0001177)1.93318922
112Oligodactyly (hands) (HP:0001180)1.93274064
113Torticollis (HP:0000473)1.93114886
114Anophthalmia (HP:0000528)1.92064796
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91067259
116Hypoplasia of the brainstem (HP:0002365)1.91067259
117Inability to walk (HP:0002540)1.89321394
118Tubulointerstitial nephritis (HP:0001970)1.87560964
119Macroorchidism (HP:0000053)1.87244478
120Genetic anticipation (HP:0003743)1.85381276
121Renovascular hypertension (HP:0100817)1.84557546
122Late onset (HP:0003584)1.84360867
123Ependymoma (HP:0002888)1.84030275
124Optic disc pallor (HP:0000543)1.83025428
125Abnormal respiratory epithelium morphology (HP:0012253)1.82967964
126Abnormal respiratory motile cilium morphology (HP:0005938)1.82967964
127Hypoglycemic coma (HP:0001325)1.81390637
128Macular degeneration (HP:0000608)1.79302974
129Glioma (HP:0009733)1.79104999
130Spastic tetraplegia (HP:0002510)1.77390116
131Papillary thyroid carcinoma (HP:0002895)1.77325869
132Excessive salivation (HP:0003781)1.76862384
133Drooling (HP:0002307)1.76862384
134Choroideremia (HP:0001139)1.76489282
135Focal dystonia (HP:0004373)1.76379870
136Congenital primary aphakia (HP:0007707)1.75037240
137Truncal ataxia (HP:0002078)1.74656881
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74283201
139Anosmia (HP:0000458)1.74035479
140Neoplasm of the adrenal cortex (HP:0100641)1.73729810
141Oligodactyly (HP:0012165)1.73410722
142Progressive inability to walk (HP:0002505)1.73074612
143Hyperglycinuria (HP:0003108)1.72162366
144Medulloblastoma (HP:0002885)1.72107647
1453-Methylglutaconic aciduria (HP:0003535)1.72087835
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.71605423
147Atonic seizures (HP:0010819)1.70742128
148Progressive microcephaly (HP:0000253)1.70261110
149Micropenis (HP:0000054)1.70057570
150Constricted visual fields (HP:0001133)1.69851905
151Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69537112
152Chronic hepatic failure (HP:0100626)1.68786054
153Abnormality of serine family amino acid metabolism (HP:0010894)1.68669471
154Abnormality of glycine metabolism (HP:0010895)1.68669471
155Febrile seizures (HP:0002373)1.68500681
156Hip dysplasia (HP:0001385)1.68433192
157Pancreatic islet-cell hyperplasia (HP:0004510)1.68215543
158Cerebral edema (HP:0002181)1.68174742
159Hypoplastic female external genitalia (HP:0012815)1.67806755
160Gout (HP:0001997)1.65656275
161Severe visual impairment (HP:0001141)1.65356758
162Hypercortisolism (HP:0001578)1.64902875
163Long toe (HP:0010511)1.64680719
164Craniofacial dystonia (HP:0012179)1.63452611
165Congenital glaucoma (HP:0001087)1.62087787
166Bifid tongue (HP:0010297)1.61027805
167Pheochromocytoma (HP:0002666)1.59366315
168Cutaneous finger syndactyly (HP:0010554)1.59119047
169Anxiety (HP:0000739)1.58799438
170Amblyopia (HP:0000646)1.58502959
171Hypoventilation (HP:0002791)1.57617367
172Unilateral renal agenesis (HP:0000122)1.56227073
173Vaginal atresia (HP:0000148)1.55620070
174Action tremor (HP:0002345)1.55237889
175Abnormality of aromatic amino acid family metabolism (HP:0004338)1.54403978
176Abnormality of the metopic suture (HP:0005556)1.54174005
177Obsessive-compulsive behavior (HP:0000722)1.53859783
178Nephrogenic diabetes insipidus (HP:0009806)1.53797289
179Generalized tonic-clonic seizures (HP:0002069)1.51118649
180Pointed chin (HP:0000307)1.50459987
181Absence seizures (HP:0002121)1.50038508
182Labial hypoplasia (HP:0000066)1.50036023
183Increased corneal curvature (HP:0100692)1.49949034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.80743423
2MARK13.69530923
3MAP4K23.25188547
4CASK3.02196910
5ZAK2.83319941
6PRKD32.77202042
7NTRK32.63923561
8BCR2.59137906
9NUAK12.29919197
10TRIM282.22873288
11SRPK12.18553108
12CDK192.05727621
13MAP3K42.03149702
14SIK22.02381431
15NTRK22.00883294
16TRIB31.92710763
17MAPK151.89626621
18WNK31.80032789
19MAP3K91.79547368
20MINK11.77858982
21UHMK11.76288833
22EPHA41.72297677
23DAPK21.71751231
24BCKDK1.61000678
25PASK1.60615942
26KSR11.58446329
27SIK11.53547356
28PAK61.52282487
29TNIK1.46062972
30HIPK21.44403028
31PDGFRA1.40897314
32SGK4941.38244546
33SGK2231.38244546
34VRK21.38192997
35MAPK131.37629891
36PRKCH1.35599673
37MAP2K71.35286226
38CAMKK11.35172864
39ERBB31.33428564
40PAK31.32859860
41MAP3K21.31327360
42MKNK11.25838116
43TYRO31.25090237
44DYRK1B1.24063906
45SGK21.23966542
46BMPR1B1.21740283
47DYRK1A1.15943936
48MAP2K41.14649783
49KSR21.13258242
50PHKG11.12899965
51PHKG21.12899965
52NTRK11.12693571
53CDK51.11954610
54SIK31.09888853
55MAP3K101.09333362
56SGK31.08760943
57RIPK11.07891890
58FGFR21.07509324
59WNK41.07480664
60CSNK1G21.04169390
61CAMK1G1.03029514
62ICK1.01955502
63PRPF4B1.01215935
64DYRK31.00942945
65MARK21.00469027
66EPHB20.99547405
67PTK60.97625328
68VRK10.96478518
69FER0.96292473
70PRKCG0.94349392
71RPS6KA20.94268677
72STK380.93786376
73RET0.91805694
74NME10.84689614
75CDC42BPA0.84459290
76PLK30.84439511
77GRK10.83274275
78CSNK1A1L0.82823050
79MKNK20.81958239
80DYRK20.80151898
81CAMK40.79740278
82FRK0.79666111
83PRKCE0.78878706
84PRKCZ0.78405175
85STK38L0.77938122
86OXSR10.77593251
87CAMKK20.77172159
88IRAK20.75962121
89ERBB20.74587704
90TAOK30.73838106
91BRD40.71984570
92LATS10.70686926
93ADRBK20.70590376
94CCNB10.68277060
95PTK20.67231442
96EPHA30.67199784
97CSNK1G30.65835583
98STK160.65200598
99PRKAA10.63612100
100FGFR40.63049154
101MAP3K10.62811005
102NEK10.61923143
103TAOK10.61686442
104PDK20.61438169
105PLK40.59562581
106CAMK2B0.57535940
107RPS6KA50.57469847
108ATR0.57333794
109ERN10.56744317
110LMTK20.55973109
111PLK10.55504542
112CDK180.55047844
113ALK0.52936381
114PIM20.52890058
115DAPK10.52815469
116CDK150.51949876
117MAP3K70.51497998
118SGK10.51318167
119DDR20.51230252
120FGFR10.51204886
121PRKD20.50929339
122CDK140.50838678
123PINK10.50295660
124AKT30.50104798
125CAMK10.49389129
126TTK0.48463748
127CSNK1A10.48033147
128CSNK1G10.47943441
129CAMK2A0.47113165
130CDK30.47052778
131PLK20.45951645
132FLT30.45339314
133CSNK1E0.45232000
134MAPK90.44219372
135RPS6KA40.43972843
136GRK50.43708957
137RPS6KA30.42801755
138PRKCI0.40953120
139PRKACA0.40811736
140CSNK1D0.40728172
141BUB10.40452419
142MAP3K60.40316803
143PKN10.39945497
144ACVR1B0.39000938
145MAPKAPK50.37892950
146ATM0.35800315
147CDK11A0.35638075
148TLK10.34333700
149PNCK0.33137370

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.79450338
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.75242725
3Oxidative phosphorylation_Homo sapiens_hsa001903.04781073
4Protein export_Homo sapiens_hsa030602.79912855
5Parkinsons disease_Homo sapiens_hsa050122.73472348
6Olfactory transduction_Homo sapiens_hsa047402.66678099
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57467492
8Insulin secretion_Homo sapiens_hsa049112.54763527
9Synaptic vesicle cycle_Homo sapiens_hsa047212.49699488
10GABAergic synapse_Homo sapiens_hsa047272.13563908
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09846023
12Proteasome_Homo sapiens_hsa030502.09845068
13Circadian entrainment_Homo sapiens_hsa047132.07588560
14RNA polymerase_Homo sapiens_hsa030201.91180212
15Huntingtons disease_Homo sapiens_hsa050161.90111426
16Base excision repair_Homo sapiens_hsa034101.86858457
17Dopaminergic synapse_Homo sapiens_hsa047281.86293971
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86133225
19Cocaine addiction_Homo sapiens_hsa050301.81996388
20Spliceosome_Homo sapiens_hsa030401.71368153
21Cholinergic synapse_Homo sapiens_hsa047251.68626257
22Amphetamine addiction_Homo sapiens_hsa050311.68594026
23Morphine addiction_Homo sapiens_hsa050321.68592284
24Type II diabetes mellitus_Homo sapiens_hsa049301.66687962
25Glutamatergic synapse_Homo sapiens_hsa047241.65823279
26Nicotine addiction_Homo sapiens_hsa050331.65820760
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65437373
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60916902
29Fatty acid elongation_Homo sapiens_hsa000621.60075960
30Alzheimers disease_Homo sapiens_hsa050101.58276949
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55333944
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52913166
33Long-term potentiation_Homo sapiens_hsa047201.49754814
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46793969
35Propanoate metabolism_Homo sapiens_hsa006401.46439466
36Non-homologous end-joining_Homo sapiens_hsa034501.45263761
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43259548
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41405273
39Ether lipid metabolism_Homo sapiens_hsa005651.37605549
40Basal transcription factors_Homo sapiens_hsa030221.37296583
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34727273
42Taste transduction_Homo sapiens_hsa047421.34373571
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34297571
44Fanconi anemia pathway_Homo sapiens_hsa034601.34055190
45Steroid biosynthesis_Homo sapiens_hsa001001.29499218
46Regulation of autophagy_Homo sapiens_hsa041401.26794404
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26005986
48RNA degradation_Homo sapiens_hsa030181.24465278
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23294517
50Cardiac muscle contraction_Homo sapiens_hsa042601.21914098
51Nitrogen metabolism_Homo sapiens_hsa009101.21540560
52Mismatch repair_Homo sapiens_hsa034301.20401915
53Circadian rhythm_Homo sapiens_hsa047101.15398439
54Serotonergic synapse_Homo sapiens_hsa047261.14732902
55Linoleic acid metabolism_Homo sapiens_hsa005911.12848021
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11971393
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10945991
58Peroxisome_Homo sapiens_hsa041461.09057426
59RNA transport_Homo sapiens_hsa030131.07122748
60Vibrio cholerae infection_Homo sapiens_hsa051101.06162378
61Gastric acid secretion_Homo sapiens_hsa049711.05732891
62Homologous recombination_Homo sapiens_hsa034401.03747926
63Butanoate metabolism_Homo sapiens_hsa006501.03637111
64Axon guidance_Homo sapiens_hsa043601.01661682
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01534540
66Endometrial cancer_Homo sapiens_hsa052131.01283164
67Melanogenesis_Homo sapiens_hsa049161.00942526
68Renin secretion_Homo sapiens_hsa049241.00694235
69Glucagon signaling pathway_Homo sapiens_hsa049221.00113348
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99845077
71Salivary secretion_Homo sapiens_hsa049700.99585659
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99512691
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97035338
74Thyroid hormone synthesis_Homo sapiens_hsa049180.94617343
75Estrogen signaling pathway_Homo sapiens_hsa049150.94159320
76Bile secretion_Homo sapiens_hsa049760.92793706
77Gap junction_Homo sapiens_hsa045400.92744848
78Sulfur metabolism_Homo sapiens_hsa009200.92303516
79cAMP signaling pathway_Homo sapiens_hsa040240.90937464
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90562632
81Oxytocin signaling pathway_Homo sapiens_hsa049210.89173973
82GnRH signaling pathway_Homo sapiens_hsa049120.86030275
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85802683
84Glioma_Homo sapiens_hsa052140.83295711
85Pancreatic secretion_Homo sapiens_hsa049720.80453600
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78577308
87Tryptophan metabolism_Homo sapiens_hsa003800.78356124
88Lysine degradation_Homo sapiens_hsa003100.78105757
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77295196
90ErbB signaling pathway_Homo sapiens_hsa040120.76561682
91mTOR signaling pathway_Homo sapiens_hsa041500.76057608
92Hedgehog signaling pathway_Homo sapiens_hsa043400.75599287
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75071892
94Fatty acid metabolism_Homo sapiens_hsa012120.74077813
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72828261
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72691179
97Long-term depression_Homo sapiens_hsa047300.72578999
98Metabolic pathways_Homo sapiens_hsa011000.71387066
99Insulin resistance_Homo sapiens_hsa049310.71241807
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71039586
101Purine metabolism_Homo sapiens_hsa002300.69855685
102beta-Alanine metabolism_Homo sapiens_hsa004100.69584974
103Pyrimidine metabolism_Homo sapiens_hsa002400.68776954
104Insulin signaling pathway_Homo sapiens_hsa049100.68634356
105mRNA surveillance pathway_Homo sapiens_hsa030150.68465310
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67688668
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64372227
108Alcoholism_Homo sapiens_hsa050340.63887435
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63666168
110N-Glycan biosynthesis_Homo sapiens_hsa005100.62611131
111Chemical carcinogenesis_Homo sapiens_hsa052040.61946866
112Basal cell carcinoma_Homo sapiens_hsa052170.60699169
113Wnt signaling pathway_Homo sapiens_hsa043100.59825726
114Calcium signaling pathway_Homo sapiens_hsa040200.59772636
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58866668
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58606385
117Collecting duct acid secretion_Homo sapiens_hsa049660.58555378
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58102384
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.57948672
120* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57869764
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.57615266
122ABC transporters_Homo sapiens_hsa020100.57601920
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.56602796
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56234651
125Ribosome_Homo sapiens_hsa030100.56089557
126Biosynthesis of amino acids_Homo sapiens_hsa012300.55583212
127AMPK signaling pathway_Homo sapiens_hsa041520.55541813
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55441633
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54584945
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54326770
131Prolactin signaling pathway_Homo sapiens_hsa049170.52792066
132Arginine biosynthesis_Homo sapiens_hsa002200.52656646
133Selenocompound metabolism_Homo sapiens_hsa004500.51280237
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.50828349
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50665267
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49126994
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.48741582
138Pyruvate metabolism_Homo sapiens_hsa006200.48185694
139Hippo signaling pathway_Homo sapiens_hsa043900.47966152
140Non-small cell lung cancer_Homo sapiens_hsa052230.47649924
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47368472
142Colorectal cancer_Homo sapiens_hsa052100.45857767
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45754227
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45289083
145Nucleotide excision repair_Homo sapiens_hsa034200.44564363
146Arginine and proline metabolism_Homo sapiens_hsa003300.44187333
147Prion diseases_Homo sapiens_hsa050200.43746967
148Glutathione metabolism_Homo sapiens_hsa004800.42213937
149Vitamin digestion and absorption_Homo sapiens_hsa049770.41426802
150Dilated cardiomyopathy_Homo sapiens_hsa054140.41207914
151Choline metabolism in cancer_Homo sapiens_hsa052310.40814854
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40580542
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40072162
154Oocyte meiosis_Homo sapiens_hsa041140.39418077
155Fat digestion and absorption_Homo sapiens_hsa049750.38256906
156Dorso-ventral axis formation_Homo sapiens_hsa043200.37945848
157Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37812409
158Sulfur relay system_Homo sapiens_hsa041220.35152647
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.34899522
160Ras signaling pathway_Homo sapiens_hsa040140.34027375
161MAPK signaling pathway_Homo sapiens_hsa040100.33913431

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