IPMK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.25794047
2positive regulation by symbiont of host defense response (GO:0052509)5.73512867
3modulation by symbiont of host defense response (GO:0052031)5.73512867
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.73512867
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.73512867
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.73512867
7modulation by symbiont of host immune response (GO:0052553)5.73512867
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.48654484
9L-phenylalanine catabolic process (GO:0006559)5.48654484
10cysteine metabolic process (GO:0006534)5.41720176
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.31947409
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30593409
13L-phenylalanine metabolic process (GO:0006558)5.30593409
14urea cycle (GO:0000050)5.25895324
15urea metabolic process (GO:0019627)5.25895324
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.21734569
17aromatic amino acid family catabolic process (GO:0009074)5.18930559
18macrophage activation involved in immune response (GO:0002281)5.01981285
19kynurenine metabolic process (GO:0070189)4.98809295
20homocysteine metabolic process (GO:0050667)4.93412652
21indole-containing compound catabolic process (GO:0042436)4.93364441
22indolalkylamine catabolic process (GO:0046218)4.93364441
23tryptophan catabolic process (GO:0006569)4.93364441
24sulfur amino acid catabolic process (GO:0000098)4.93191806
25serine family amino acid catabolic process (GO:0009071)4.83449193
26regulation of bile acid biosynthetic process (GO:0070857)4.82862841
27drug catabolic process (GO:0042737)4.81703596
28detection of external biotic stimulus (GO:0098581)4.80851375
29nitrogen cycle metabolic process (GO:0071941)4.73928582
30intestinal cholesterol absorption (GO:0030299)4.72066275
31detection of other organism (GO:0098543)4.66012904
32positive regulation of gamma-delta T cell activation (GO:0046645)4.65828963
33tryptophan metabolic process (GO:0006568)4.64958686
34bile acid and bile salt transport (GO:0015721)4.63163132
35cellular extravasation (GO:0045123)4.62984001
36intestinal absorption (GO:0050892)4.61045337
37regulation of cholesterol homeostasis (GO:2000188)4.57273752
38regulation of interferon-beta biosynthetic process (GO:0045357)4.56135518
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51891831
40high-density lipoprotein particle remodeling (GO:0034375)4.51112996
41negative regulation of sterol transport (GO:0032372)4.42514954
42negative regulation of cholesterol transport (GO:0032375)4.42514954
43amino-acid betaine metabolic process (GO:0006577)4.41945165
44response to peptidoglycan (GO:0032494)4.41606814
45negative regulation of cell killing (GO:0031342)4.40838285
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.40838285
47lysine metabolic process (GO:0006553)4.38516249
48lysine catabolic process (GO:0006554)4.38516249
49glyoxylate metabolic process (GO:0046487)4.38347799
50bile acid biosynthetic process (GO:0006699)4.35901136
51neutrophil activation involved in immune response (GO:0002283)4.31763362
52bile acid metabolic process (GO:0008206)4.26382552
53urate metabolic process (GO:0046415)4.25511694
54detection of biotic stimulus (GO:0009595)4.23565080
55microglial cell activation (GO:0001774)4.21353447
56protein carboxylation (GO:0018214)4.18633366
57peptidyl-glutamic acid carboxylation (GO:0017187)4.18633366
58macrophage activation (GO:0042116)4.17546391
59alpha-linolenic acid metabolic process (GO:0036109)4.13998072
60regulation of triglyceride catabolic process (GO:0010896)4.12335597
61regulation of protein activation cascade (GO:2000257)4.12061899
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.11055736
63phospholipid efflux (GO:0033700)4.10284898
64drug transmembrane transport (GO:0006855)4.06361708
65glycine metabolic process (GO:0006544)4.06176788
66serine family amino acid metabolic process (GO:0009069)4.05994829
67neutrophil mediated immunity (GO:0002446)4.01760066
68complement activation, alternative pathway (GO:0006957)4.00459316
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.98989012
70triglyceride homeostasis (GO:0070328)3.97369880
71acylglycerol homeostasis (GO:0055090)3.97369880
72reverse cholesterol transport (GO:0043691)3.94647098
73regulation of complement activation (GO:0030449)3.89623481
74flavonoid metabolic process (GO:0009812)3.86930662
75response to host immune response (GO:0052572)3.86190508
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86190508
77detection of bacterium (GO:0016045)3.84589466
78regulation of cholesterol esterification (GO:0010872)3.82945269
79negative regulation of fibrinolysis (GO:0051918)3.80267578
80cellular glucuronidation (GO:0052695)3.79696811
81plasma lipoprotein particle remodeling (GO:0034369)3.79573192
82protein-lipid complex remodeling (GO:0034368)3.79573192
83macromolecular complex remodeling (GO:0034367)3.79573192
84production of molecular mediator involved in inflammatory response (GO:0002532)3.78748803
85exogenous drug catabolic process (GO:0042738)3.76838018
86aromatic amino acid family metabolic process (GO:0009072)3.73493708
87plasma lipoprotein particle assembly (GO:0034377)3.73086666
88cholesterol efflux (GO:0033344)3.72414099
89serine family amino acid biosynthetic process (GO:0009070)3.69750238
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.67611363
91glutamate metabolic process (GO:0006536)3.67152289
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62886845
93response to host (GO:0075136)3.62886845
94response to host defenses (GO:0052200)3.62886845
95cellular modified amino acid catabolic process (GO:0042219)3.61019301
96alpha-amino acid catabolic process (GO:1901606)3.60435016
97regulation of fibrinolysis (GO:0051917)3.59939950
98phospholipid homeostasis (GO:0055091)3.59597633
99lipoprotein metabolic process (GO:0042157)3.57787570
100sterol homeostasis (GO:0055092)3.57090685
101cholesterol homeostasis (GO:0042632)3.56141229
102regulation of gamma-delta T cell activation (GO:0046643)3.51852115
103negative regulation of interleukin-12 production (GO:0032695)3.51670490
104tyrosine metabolic process (GO:0006570)3.51000310
105protein-lipid complex assembly (GO:0065005)3.50834499
106drug transport (GO:0015893)3.45354467
107dicarboxylic acid biosynthetic process (GO:0043650)3.45287124
108regulation of B cell receptor signaling pathway (GO:0050855)3.44220044
109positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.41177113
110very-low-density lipoprotein particle assembly (GO:0034379)3.40999501
111plasma lipoprotein particle clearance (GO:0034381)3.40820888
112neutrophil activation (GO:0042119)3.40205665
113embryonic process involved in female pregnancy (GO:0060136)3.39113034
114ethanol oxidation (GO:0006069)3.39105292
115benzene-containing compound metabolic process (GO:0042537)3.38875596
116cellular ketone body metabolic process (GO:0046950)3.38833051
117cellular amino acid catabolic process (GO:0009063)3.38658156
118drug metabolic process (GO:0017144)3.38441865
119imidazole-containing compound metabolic process (GO:0052803)3.36825309
120negative regulation of lymphocyte mediated immunity (GO:0002707)3.32773401
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32623969
122response to nitrosative stress (GO:0051409)3.30978734
123positive regulation of cellular amide metabolic process (GO:0034250)3.30470974
124indolalkylamine metabolic process (GO:0006586)3.29149983
125myeloid leukocyte mediated immunity (GO:0002444)3.28051863
126negative regulation of fatty acid biosynthetic process (GO:0045717)3.27453502
127antigen processing and presentation of endogenous antigen (GO:0019883)3.23184009
128iron ion import (GO:0097286)3.23128092
129T-helper 1 type immune response (GO:0042088)3.21805702
130hormone catabolic process (GO:0042447)3.20009355
131positive regulation of lipid catabolic process (GO:0050996)3.18839190
132glucuronate metabolic process (GO:0019585)3.17825879
133uronic acid metabolic process (GO:0006063)3.17825879
134positive regulation of lipoprotein lipase activity (GO:0051006)3.16507576
135positive regulation of triglyceride lipase activity (GO:0061365)3.16507576
136respiratory burst (GO:0045730)3.16045088
137amine catabolic process (GO:0009310)3.14027651
138cellular biogenic amine catabolic process (GO:0042402)3.14027651
139negative regulation of lipase activity (GO:0060192)3.13934927
140ethanol metabolic process (GO:0006067)3.13886517
141UDP-N-acetylglucosamine metabolic process (GO:0006047)3.13363253
142carnitine metabolic process (GO:0009437)3.12967472
143arginine metabolic process (GO:0006525)3.12639291
144short-chain fatty acid metabolic process (GO:0046459)3.12295936
145regulation of T-helper 2 cell differentiation (GO:0045628)3.10769541
146hypotonic response (GO:0006971)3.09829781
147granulocyte activation (GO:0036230)3.09450464
148lipid homeostasis (GO:0055088)3.04688591
149regulation of gamma-delta T cell differentiation (GO:0045586)3.03535206
150germinal center formation (GO:0002467)3.03341618
151lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03288767
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02861727
153fibrinolysis (GO:0042730)3.02689630
154histone H3-K36 demethylation (GO:0070544)3.02277460
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01763246
156positive regulation of interferon-alpha production (GO:0032727)3.00806077
157leukocyte migration involved in inflammatory response (GO:0002523)2.96247836
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.95402965
159response to muramyl dipeptide (GO:0032495)2.94878623
160myeloid cell activation involved in immune response (GO:0002275)2.94507587
161negative regulation of B cell mediated immunity (GO:0002713)2.93288742
162negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93288742
163negative regulation of type 2 immune response (GO:0002829)2.86713902
164B cell receptor signaling pathway (GO:0050853)2.85576503
165regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84318161
166cellular response to ethanol (GO:0071361)2.84097301
167I-kappaB phosphorylation (GO:0007252)2.81005130
168regulation of leukocyte degranulation (GO:0043300)2.79830925
169negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78188063
170negative regulation of leukocyte mediated immunity (GO:0002704)2.76637274
171positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76586086
172regulation of mast cell degranulation (GO:0043304)2.75514243
173regulation of interferon-alpha production (GO:0032647)2.74143682
174dendritic cell migration (GO:0036336)2.73081531
175regulation of interleukin-8 biosynthetic process (GO:0045414)2.72365230
176negative regulation of T cell mediated immunity (GO:0002710)2.68767899
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67301299
178response to interleukin-15 (GO:0070672)2.66229252
179leukocyte aggregation (GO:0070486)2.65856768
180positive regulation of mast cell activation (GO:0033005)2.65382059
181regulation of macrophage cytokine production (GO:0010935)2.63762403
182negative regulation of erythrocyte differentiation (GO:0045647)2.62756702
183regulation of cellular amide metabolic process (GO:0034248)2.62646820
184regulation of mast cell activation involved in immune response (GO:0033006)2.60113818
185negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58032123
186positive regulation of leukocyte degranulation (GO:0043302)2.57402116
187regulation of toll-like receptor signaling pathway (GO:0034121)2.55045335
188response to laminar fluid shear stress (GO:0034616)2.55032067
189neutrophil chemotaxis (GO:0030593)2.54702818
190positive regulation of macrophage cytokine production (GO:0060907)2.54594815
191negative regulation of T-helper cell differentiation (GO:0045623)2.52382383
192negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52382383
193dendritic cell chemotaxis (GO:0002407)2.52051540
194regulation of regulated secretory pathway (GO:1903305)2.50859766
195regulation of interleukin-6 biosynthetic process (GO:0045408)2.48261771
196neutrophil migration (GO:1990266)2.47335743
197regulation of mast cell activation (GO:0033003)2.47054388
198response to vitamin D (GO:0033280)2.46390877
199hepatocyte apoptotic process (GO:0097284)2.45916204
200positive regulation of regulated secretory pathway (GO:1903307)2.44659513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.35412461
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.17773761
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.56743606
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.96329298
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.68463321
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47312796
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.46937060
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.43621444
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.22597664
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.19265556
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.16751240
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11519165
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.02061301
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93079891
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.92184855
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84376296
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83968627
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.58034078
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.55057980
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43580767
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38364345
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36761599
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09966929
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07804217
25RUNX_20019798_ChIP-Seq_JUKART_Human2.06299467
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01933730
27SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01456412
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00536176
29VDR_24787735_ChIP-Seq_THP-1_Human1.93244527
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.88287314
31SPI1_23547873_ChIP-Seq_NB4_Human1.82763079
32GATA6_25053715_ChIP-Seq_YYC3_Human1.81710219
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81228025
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79992454
35SPI1_23127762_ChIP-Seq_K562_Human1.78475242
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76562045
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73000710
38AR_21909140_ChIP-Seq_LNCAP_Human1.72020327
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.63634149
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.62413295
41CLOCK_20551151_ChIP-Seq_293T_Human1.62218126
42GATA4_25053715_ChIP-Seq_YYC3_Human1.61275714
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57919468
44VDR_24763502_ChIP-Seq_THP-1_Human1.57302616
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57002274
46MYB_26560356_Chip-Seq_TH2_Human1.54169717
47* PU_27001747_Chip-Seq_BMDM_Mouse1.53959225
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52062963
49SCL_19346495_ChIP-Seq_HPC-7_Human1.50336551
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.50257369
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49927091
52ZNF263_19887448_ChIP-Seq_K562_Human1.48429780
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45974985
54* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44064134
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.43799596
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.43221870
57* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43196745
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41859554
59MYB_26560356_Chip-Seq_TH1_Human1.40203713
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37948573
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.36780536
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35399179
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35233652
64* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26696377
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.25813725
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25398969
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24323845
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23363826
69FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.23131594
70* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22283072
71MAF_26560356_Chip-Seq_TH1_Human1.21495339
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18476099
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17918411
74E2F7_22180533_ChIP-Seq_HELA_Human1.17117570
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16651464
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.15991156
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15748818
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14101501
79* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14080629
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13776931
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13313545
82ATF3_27146783_Chip-Seq_COLON_Human1.13242213
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13165423
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11721306
85* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10026170
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09662111
87GATA3_27048872_Chip-Seq_THYMUS_Human1.09424024
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09145076
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06904229
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06478910
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06150221
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.05264705
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05187692
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05024641
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04725655
96GATA2_19941826_ChIP-Seq_K562_Human1.04170084
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03709092
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.02175145
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01877896
100AHR_22903824_ChIP-Seq_MCF-7_Human1.01275274
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01263435
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.00867312
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98763454
104GATA1_22025678_ChIP-Seq_K562_Human0.97862909
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.96160514
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95924583
107RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95219641
108* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95104815
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95104815
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94798410
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94616316
112EGR1_19374776_ChIP-ChIP_THP-1_Human0.93452546
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93175315
114VDR_21846776_ChIP-Seq_THP-1_Human0.93037705
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.92141137
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.91975971
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91718783
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90113645
119TP53_16413492_ChIP-PET_HCT116_Human0.89953380
120CDX2_22108803_ChIP-Seq_LS180_Human0.89084550
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.88982058
122UTX_26944678_Chip-Seq_JUKART_Human0.88438363
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87821987
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87522498
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86897944
126* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85879795
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85191727
128RACK7_27058665_Chip-Seq_MCF-7_Human0.84630308
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82960222
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82650919
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82113648
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81607004
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81607004
134* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81146460
135SOX2_20726797_ChIP-Seq_SW620_Human0.81023541
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80881921
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80552053
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80390697
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79157417
140* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79152481
141ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78890775
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78541226
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78541226
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78541226
145NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78488836
146CREB1_26743006_Chip-Seq_LNCaP_Human0.77605722
147* KAP1_27257070_Chip-Seq_ESCs_Mouse0.74983367
148* CHD1_26751641_Chip-Seq_LNCaP_Human0.74096336
149* GATA3_24758297_ChIP-Seq_MCF-7_Human0.73431982
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73067732
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72157431
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.71639996
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71491815
154TCF7_22412390_ChIP-Seq_EML_Mouse0.70121647
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69323194
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67850505
157TP63_23658742_ChIP-Seq_EP156T_Human0.66041428
158* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65903164
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.65787922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.46793952
2MP0002139_abnormal_hepatobiliary_system6.57128545
3MP0005085_abnormal_gallbladder_physiolo5.25300329
4MP0005365_abnormal_bile_salt4.91276693
5MP0003724_increased_susceptibility_to4.73331879
6MP0008875_abnormal_xenobiotic_pharmacok4.26859500
7MP0003252_abnormal_bile_duct3.63835600
8MP0000678_abnormal_parathyroid_gland3.50132263
9MP0003806_abnormal_nucleotide_metabolis3.07414441
10MP0001666_abnormal_nutrient_absorption3.00975732
11MP0010234_abnormal_vibrissa_follicle2.90173033
12MP0009840_abnormal_foam_cell2.72738067
13MP0010329_abnormal_lipoprotein_level2.70552058
14MP0000569_abnormal_digit_pigmentation2.65577755
15MP0001835_abnormal_antigen_presentation2.55742781
16MP0008260_abnormal_autophagy2.52873316
17MP0004019_abnormal_vitamin_homeostasis2.42491804
18MP0002419_abnormal_innate_immunity2.35614795
19MP0003705_abnormal_hypodermis_morpholog2.30485289
20MP0002009_preneoplasia2.23921270
21MP0003011_delayed_dark_adaptation2.15262552
22MP0004264_abnormal_extraembryonic_tissu2.14574949
23MP0005332_abnormal_amino_acid2.13896479
24MP0003183_abnormal_peptide_metabolism2.13841289
25MP0003828_pulmonary_edema2.11249221
26MP0003191_abnormal_cellular_cholesterol1.98047007
27MP0002138_abnormal_hepatobiliary_system1.93538400
28MP0001800_abnormal_humoral_immune1.91126450
29MP0009785_altered_susceptibility_to1.90548534
30MP0005025_abnormal_response_to1.85956690
31MP0000609_abnormal_liver_physiology1.83725726
32MP0005451_abnormal_body_composition1.82172593
33MP0008057_abnormal_DNA_replication1.82063266
34MP0006082_CNS_inflammation1.81504071
35MP0005000_abnormal_immune_tolerance1.80234046
36MP0002452_abnormal_antigen_presenting1.71107285
37MP0000465_gastrointestinal_hemorrhage1.69625299
38MP0002909_abnormal_adrenal_gland1.68832243
39MP0002723_abnormal_immune_serum1.67315194
40MP0002796_impaired_skin_barrier1.66302394
41MP0002166_altered_tumor_susceptibility1.65974658
42MP0003868_abnormal_feces_composition1.65184658
43MP0003221_abnormal_cardiomyocyte_apopto1.64100908
44MP0003195_calcinosis1.63151969
45MP0010352_gastrointestinal_tract_polyps1.61837140
46MP0002420_abnormal_adaptive_immunity1.55050423
47MP0001819_abnormal_immune_cell1.54463657
48MP0005387_immune_system_phenotype1.54319982
49MP0001790_abnormal_immune_system1.54319982
50MP0005464_abnormal_platelet_physiology1.53936509
51MP0003300_gastrointestinal_ulcer1.53109893
52MP0002118_abnormal_lipid_homeostasis1.51245976
53MP0003690_abnormal_glial_cell1.49491661
54MP0005409_darkened_coat_color1.46983254
55MP0000858_altered_metastatic_potential1.45244367
56MP0001533_abnormal_skeleton_physiology1.45182942
57MP0009643_abnormal_urine_homeostasis1.45164865
58MP0002132_abnormal_respiratory_system1.45012896
59MP0004883_abnormal_blood_vessel1.44291088
60MP0003091_abnormal_cell_migration1.38866595
61MP0000685_abnormal_immune_system1.38289813
62MP0001764_abnormal_homeostasis1.38153890
63MP0005083_abnormal_biliary_tract1.35489768
64MP0004484_altered_response_of1.35166864
65MP0000516_abnormal_urinary_system1.33778290
66MP0005367_renal/urinary_system_phenotyp1.33778290
67MP0005319_abnormal_enzyme/_coenzyme1.32487802
68MP0002405_respiratory_system_inflammati1.30456434
69MP0005164_abnormal_response_to1.29695280
70MP0001845_abnormal_inflammatory_respons1.28715307
71MP0003172_abnormal_lysosome_physiology1.27811380
72MP0002148_abnormal_hypersensitivity_rea1.27233403
73MP0006054_spinal_hemorrhage1.25743183
74MP0004185_abnormal_adipocyte_glucose1.18152771
75MP0000716_abnormal_immune_system1.17088918
76MP0003453_abnormal_keratinocyte_physiol1.17062442
77MP0002998_abnormal_bone_remodeling1.15414653
78MP0002006_tumorigenesis1.14938294
79MP0003075_altered_response_to1.14900658
80MP0002398_abnormal_bone_marrow1.14421720
81MP0005671_abnormal_response_to1.14332486
82MP0001851_eye_inflammation1.14307904
83MP0003763_abnormal_thymus_physiology1.13459441
84MP0004381_abnormal_hair_follicle1.13245563
85MP0002254_reproductive_system_inflammat1.12651308
86MP0003448_altered_tumor_morphology1.12392218
87MP0009278_abnormal_bone_marrow1.09773112
88MP0004043_abnormal_pH_regulation1.05526420
89MP0002396_abnormal_hematopoietic_system1.04350703
90MP0008004_abnormal_stomach_pH1.02092658
91MP0009053_abnormal_anal_canal1.01242132
92MP0003718_maternal_effect1.00858920
93MP0002722_abnormal_immune_system1.00640349
94MP0010678_abnormal_skin_adnexa0.99338817
95MP0005076_abnormal_cell_differentiation0.99260336
96MP0000604_amyloidosis0.98561587
97MP0005647_abnormal_sex_gland0.97414037
98MP0005636_abnormal_mineral_homeostasis0.96577758
99MP0005584_abnormal_enzyme/coenzyme_acti0.96120028
100MP0001915_intracranial_hemorrhage0.96091988
101MP0000689_abnormal_spleen_morphology0.95726415
102MP0005551_abnormal_eye_electrophysiolog0.94567648
103MP0005397_hematopoietic_system_phenotyp0.94346825
104MP0001545_abnormal_hematopoietic_system0.94346825
105MP0005408_hypopigmentation0.94135509
106MP0005501_abnormal_skin_physiology0.93993123
107MP0003866_abnormal_defecation0.92749944
108MP0000598_abnormal_liver_morphology0.92616558
109MP0001216_abnormal_epidermal_layer0.90833792
110MP0002277_abnormal_respiratory_mucosa0.89319975
111MP0004808_abnormal_hematopoietic_stem0.88987431
112MP0004947_skin_inflammation0.87984708
113MP0009764_decreased_sensitivity_to0.87475044
114MP0002429_abnormal_blood_cell0.86978454
115MP0002136_abnormal_kidney_physiology0.86788944
116MP0005058_abnormal_lysosome_morphology0.85926813
117MP0000703_abnormal_thymus_morphology0.82534077
118MP0010307_abnormal_tumor_latency0.81896472
119MP0001849_ear_inflammation0.80715657
120MP0000015_abnormal_ear_pigmentation0.80374614
121MP0001756_abnormal_urination0.80079803
122MP0000462_abnormal_digestive_system0.80076225
123MP0009333_abnormal_splenocyte_physiolog0.77508546
124MP0003329_amyloid_beta_deposits0.77129884
125MP0000477_abnormal_intestine_morphology0.76089942
126MP0002060_abnormal_skin_morphology0.75087219
127MP0003303_peritoneal_inflammation0.73274145
128MP0005666_abnormal_adipose_tissue0.73038866
129MP0001765_abnormal_ion_homeostasis0.71258856
130MP0008961_abnormal_basal_metabolism0.70122625
131MP0005023_abnormal_wound_healing0.68890342
132MP0000377_abnormal_hair_follicle0.68718137
133MP0010155_abnormal_intestine_physiology0.68429741
134MP0005174_abnormal_tail_pigmentation0.68259484
135MP0005395_other_phenotype0.66017456
136MP0009765_abnormal_xenobiotic_induced0.65074741
137MP0003693_abnormal_embryo_hatching0.63253804
138MP0003186_abnormal_redox_activity0.63224001
139MP0002971_abnormal_brown_adipose0.62903790
140MP0009763_increased_sensitivity_to0.62790342
141MP0005220_abnormal_exocrine_pancreas0.62318177
142MP0009642_abnormal_blood_homeostasis0.62270006
143MP0001873_stomach_inflammation0.61764933
144MP0002098_abnormal_vibrissa_morphology0.60929899
145MP0003656_abnormal_erythrocyte_physiolo0.60352105
146MP0000383_abnormal_hair_follicle0.60095352
147MP0002877_abnormal_melanocyte_morpholog0.59871289
148MP0000579_abnormal_nail_morphology0.58657755
149MP0005376_homeostasis/metabolism_phenot0.58638090
150MP0003566_abnormal_cell_adhesion0.58089048
151MP0005266_abnormal_metabolism0.56430414
152MP0009672_abnormal_birth_weight0.56200881
153MP0008469_abnormal_protein_level0.55011313
154MP0000490_abnormal_crypts_of0.55011170
155MP0003436_decreased_susceptibility_to0.54961997
156MP0005310_abnormal_salivary_gland0.54899899
157MP0000467_abnormal_esophagus_morphology0.54425565
158MP0005167_abnormal_blood-brain_barrier0.52353775
159MP0002078_abnormal_glucose_homeostasis0.52080925
160MP0005248_abnormal_Harderian_gland0.51197126
161MP0000538_abnormal_urinary_bladder0.50738388
162MP0005187_abnormal_penis_morphology0.50602081
163MP0009931_abnormal_skin_appearance0.49982274
164MP0005381_digestive/alimentary_phenotyp0.49678290
165MP0005166_decreased_susceptibility_to0.49109551
166MP0000427_abnormal_hair_cycle0.48985868
167MP0005253_abnormal_eye_physiology0.48829673
168* MP0002086_abnormal_extraembryonic_tissu0.48569186
169MP0008873_increased_physiological_sensi0.48089367
170MP0001730_embryonic_growth_arrest0.47810073
171MP0001663_abnormal_digestive_system0.47758330
172MP0001324_abnormal_eye_pigmentation0.45776899

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.49301905
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.94992528
3Eczematoid dermatitis (HP:0000976)5.49724017
4Deep venous thrombosis (HP:0002625)5.42075012
5Hypobetalipoproteinemia (HP:0003563)5.40990937
6Xanthomatosis (HP:0000991)5.09268426
7Recurrent bacterial skin infections (HP:0005406)4.94759485
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.94723594
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.82683690
10Recurrent abscess formation (HP:0002722)4.68762174
11Orchitis (HP:0100796)4.49294597
12Retrobulbar optic neuritis (HP:0100654)4.32620772
13Optic neuritis (HP:0100653)4.32620772
14Pigmentary retinal degeneration (HP:0001146)4.27055671
15Tetany (HP:0001281)4.25917005
16Myositis (HP:0100614)4.25730024
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.13569258
18Hyperglycinuria (HP:0003108)4.06672565
19Hypolipoproteinemia (HP:0010981)4.05426631
20Fat malabsorption (HP:0002630)4.04351299
21Prolonged partial thromboplastin time (HP:0003645)3.91144744
22Abnormality of macrophages (HP:0004311)3.79790457
23Hyperphosphatemia (HP:0002905)3.77249161
24Epidermoid cyst (HP:0200040)3.74902641
25Complement deficiency (HP:0004431)3.74804762
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73690234
27Hyperglycinemia (HP:0002154)3.65183128
28Hyperammonemia (HP:0001987)3.64725305
29Abnormality of glycine metabolism (HP:0010895)3.59948063
30Abnormality of serine family amino acid metabolism (HP:0010894)3.59948063
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.51675713
32Malnutrition (HP:0004395)3.38830689
33Hypoalphalipoproteinemia (HP:0003233)3.37205188
34Conjugated hyperbilirubinemia (HP:0002908)3.36746874
35Hyperlipoproteinemia (HP:0010980)3.34520241
36Abnormality of the common coagulation pathway (HP:0010990)3.33874804
37Keratoconjunctivitis sicca (HP:0001097)3.33368684
38Abnormality of pyrimidine metabolism (HP:0004353)3.33192715
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.32286693
40Papillary thyroid carcinoma (HP:0002895)3.28985826
41Hypoglycemic coma (HP:0001325)3.23426009
42Gingivitis (HP:0000230)3.22133967
43Acanthocytosis (HP:0001927)3.20675073
44Ketosis (HP:0001946)3.19581401
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.18278484
46Abnormality of nucleobase metabolism (HP:0010932)3.17650751
47Congenital stationary night blindness (HP:0007642)3.14128187
48Gastrointestinal infarctions (HP:0005244)3.10145168
49Abnormality of purine metabolism (HP:0004352)3.09879769
50Subacute progressive viral hepatitis (HP:0006572)3.06792322
51Chorioretinal atrophy (HP:0000533)3.01566155
52Peritonitis (HP:0002586)2.98760250
53Myocardial infarction (HP:0001658)2.97846681
54Recurrent skin infections (HP:0001581)2.95760902
55Spontaneous hematomas (HP:0007420)2.94444403
56Keratoconjunctivitis (HP:0001096)2.92588814
57Mediastinal lymphadenopathy (HP:0100721)2.92555010
58Abnormality of methionine metabolism (HP:0010901)2.90784434
59Abnormality of complement system (HP:0005339)2.89412327
60Hypercholesterolemia (HP:0003124)2.88790307
61Gingival bleeding (HP:0000225)2.84442437
62Gout (HP:0001997)2.83668324
63Joint hemorrhage (HP:0005261)2.82431579
64Arterial thrombosis (HP:0004420)2.79027356
65Abnormality of the intrinsic pathway (HP:0010989)2.78633213
66Increased IgE level (HP:0003212)2.77293620
67Spastic diplegia (HP:0001264)2.75295033
68Amyloidosis (HP:0011034)2.69340131
69Hydroxyprolinuria (HP:0003080)2.68283572
70Abnormality of proline metabolism (HP:0010907)2.68283572
71Stomatitis (HP:0010280)2.67870578
72Steatorrhea (HP:0002570)2.65967166
73Hepatocellular carcinoma (HP:0001402)2.60140748
74T lymphocytopenia (HP:0005403)2.60116382
75Esophageal varix (HP:0002040)2.58541034
76Ketoacidosis (HP:0001993)2.55047527
77Recurrent fungal infections (HP:0002841)2.54712127
78Disinhibition (HP:0000734)2.53969359
79Abnormality of calcium-phosphate metabolism (HP:0100530)2.53224668
80Cone-rod dystrophy (HP:0000548)2.47609779
81Cellulitis (HP:0100658)2.47570714
82Sensorimotor neuropathy (HP:0007141)2.47503788
83Elevated erythrocyte sedimentation rate (HP:0003565)2.44015925
84Meningitis (HP:0001287)2.43196342
85Abnormality of T cell number (HP:0011839)2.37975260
86Ileus (HP:0002595)2.35260456
87Urticaria (HP:0001025)2.33780897
88Encephalitis (HP:0002383)2.30339147
89Curly hair (HP:0002212)2.30142597
90Vasculitis (HP:0002633)2.29548395
91Hyperbilirubinemia (HP:0002904)2.28749522
92Hypoglycemic seizures (HP:0002173)2.28245442
93Gangrene (HP:0100758)2.27062680
94Polycythemia (HP:0001901)2.26712617
95Viral hepatitis (HP:0006562)2.25981330
96Right ventricular cardiomyopathy (HP:0011663)2.24801536
97Spontaneous abortion (HP:0005268)2.19763970
98Vascular calcification (HP:0004934)2.18471898
99Chronic mucocutaneous candidiasis (HP:0002728)2.15638261
100Recurrent cutaneous fungal infections (HP:0011370)2.15638261
101Bony spicule pigmentary retinopathy (HP:0007737)2.14882279
102Pulmonary embolism (HP:0002204)2.14059719
103Poikilocytosis (HP:0004447)2.13603605
104Increased purine levels (HP:0004368)2.13085746
105Hyperuricemia (HP:0002149)2.13085746
106Pancreatitis (HP:0001733)2.12694729
107Abnormality of the peritoneum (HP:0002585)2.11435038
108Hypochromic microcytic anemia (HP:0004840)2.10126406
109Metabolic acidosis (HP:0001942)2.09562447
110Chest pain (HP:0100749)2.09002702
111Obstructive lung disease (HP:0006536)2.08859591
112Chronic obstructive pulmonary disease (HP:0006510)2.08859591
113Episodic fever (HP:0001954)2.08807817
114Thickened calvaria (HP:0002684)2.08214687
115Abnormality of fatty-acid metabolism (HP:0004359)2.08158126
116Thyroid carcinoma (HP:0002890)2.06990806
117Osteomyelitis (HP:0002754)2.06369659
118Posterior subcapsular cataract (HP:0007787)2.04958785
119Periodontitis (HP:0000704)2.04916204
120Resting tremor (HP:0002322)2.04323483
121Systemic lupus erythematosus (HP:0002725)2.02469890
122Segmental peripheral demyelination/remyelination (HP:0003481)2.01444216
123Abnormality of serum amino acid levels (HP:0003112)2.01237150
124Autoimmune thrombocytopenia (HP:0001973)2.01067535
125Rickets (HP:0002748)2.00323847
126Hemoptysis (HP:0002105)2.00092137
127Hyperglycemia (HP:0003074)1.99095011
128Abnormality of chloride homeostasis (HP:0011422)1.98844263
129Skin nodule (HP:0200036)1.98792883
130Late onset (HP:0003584)1.97438425
131Hyperactive renin-angiotensin system (HP:0000841)1.96976160
132Syringomyelia (HP:0003396)1.96714994
133Spinal cord lesions (HP:0100561)1.96714994
134Increased CSF protein (HP:0002922)1.95194136
135Delayed CNS myelination (HP:0002188)1.93486631
136Irritability (HP:0000737)1.93336872
137Cholecystitis (HP:0001082)1.92674348
138Abnormal gallbladder physiology (HP:0012438)1.92674348
139Slow saccadic eye movements (HP:0000514)1.92639354
140Abnormal enzyme/coenzyme activity (HP:0012379)1.92372262
141Abnormality of transition element cation homeostasis (HP:0011030)1.91967275
142Recurrent viral infections (HP:0004429)1.90963615
143Loss of speech (HP:0002371)1.89391852
144Lip pit (HP:0100267)1.89042457
145Nephrolithiasis (HP:0000787)1.88450072
146Thrombophlebitis (HP:0004418)1.86760062
147Transitional cell carcinoma of the bladder (HP:0006740)1.85855393
148Alkalosis (HP:0001948)1.85749790
149Vacuolated lymphocytes (HP:0001922)1.85678894
150Cardiovascular calcification (HP:0011915)1.84813264
151Dyschromatopsia (HP:0007641)1.84280738
152Macular degeneration (HP:0000608)1.83577913
153Confusion (HP:0001289)1.83122978
154Abnormality of the endocardium (HP:0004306)1.82054312
155Pulmonary infiltrates (HP:0002113)1.81805715
156Dehydration (HP:0001944)1.81039204
157Bladder carcinoma (HP:0002862)1.80863984
158Bladder neoplasm (HP:0009725)1.80863984
159Hyperinsulinemic hypoglycemia (HP:0000825)1.80760825
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.79279893
161Abnormality of vitamin metabolism (HP:0100508)1.79020743
162Subcapsular cataract (HP:0000523)1.78915180
163Vertebral arch anomaly (HP:0008438)1.78687935
164Abnormal cartilage morphology (HP:0002763)1.78066749
165Inflammation of the large intestine (HP:0002037)1.77378058
166Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77364029
167Widely patent fontanelles and sutures (HP:0004492)1.76781955
168Biliary tract neoplasm (HP:0100574)1.76369094
169Tetraparesis (HP:0002273)1.75826599
170Epistaxis (HP:0000421)1.75144209
171Abnormality of alkaline phosphatase activity (HP:0004379)1.74928821
172Leukocytosis (HP:0001974)1.74743530
173Recurrent gram-negative bacterial infections (HP:0005420)1.73898581
174Prolonged bleeding time (HP:0003010)1.73678809
175Neoplasm of the tracheobronchial system (HP:0100552)1.73501817
176Symptomatic seizures (HP:0011145)1.73179713
177Anorexia (HP:0002039)1.72268640
178Coarse hair (HP:0002208)1.71984481
179Glomerulopathy (HP:0100820)1.69514924
180Sepsis (HP:0100806)1.67474413
181Interstitial pulmonary disease (HP:0006530)1.67422501
182Decreased motor nerve conduction velocity (HP:0003431)1.67120743
183Gastrointestinal inflammation (HP:0004386)1.66097611
184Hypocalcemia (HP:0002901)1.64275969
185Premature loss of primary teeth (HP:0006323)1.63584050
186Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63583254
187Micronodular cirrhosis (HP:0001413)1.63521112
188Flat acetabular roof (HP:0003180)1.61688853
189Colitis (HP:0002583)1.60861763
190Absent frontal sinuses (HP:0002688)1.59727729
191Menstrual irregularities (HP:0000858)1.58785269
192Termporal pattern (HP:0011008)1.57866203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.68459677
2RIPK43.45299240
3FRK3.37281382
4ERN12.89215887
5CDK122.87038422
6TAOK32.79749534
7BLK2.75754052
8IRAK42.70253498
9MAP3K142.56706034
10MST1R2.50563736
11ERBB42.45235017
12STK242.41313640
13YES12.22701272
14MAP3K102.17671500
15PKN22.12092187
16STK32.07048339
17STK38L1.98521572
18EEF2K1.98206981
19STK101.94131139
20BMPR21.93618468
21MAP3K21.83685733
22EPHA21.80171901
23EPHA31.77929985
24PRPF4B1.74325021
25FGFR41.71752080
26MAP3K31.71558612
27GRK11.70256783
28PTK61.70022321
29TAOK11.68949222
30TTK1.68472112
31MAP3K11.66784246
32SIK11.62869337
33IRAK11.62671428
34LATS21.52434308
35FGR1.50619124
36KSR11.47080484
37TRIB31.46634767
38RIPK11.45708372
39BRD41.44126326
40MST41.42952405
41BCKDK1.40860809
42IRAK21.40538477
43GRK61.40340426
44AKT31.39588108
45TYK21.38234261
46KSR21.33411509
47MAP3K131.32950725
48ZAP701.32709087
49IKBKE1.28975250
50NEK21.27427982
51CDK61.24327043
52MET1.23041272
53MAPK111.20142125
54WNK11.19214786
55HCK1.15558746
56FES1.13179905
57JAK31.12411990
58SIK31.10566593
59BTK1.09975861
60MATK1.07015759
61JAK21.03532893
62MAP3K80.99801502
63SGK20.99511663
64PRKAA20.98088676
65MAP3K60.98046227
66INSRR0.97471694
67MAP4K10.95835150
68MAP3K90.94696637
69MAPKAPK30.93902328
70NEK60.90951759
71RPS6KB20.88962779
72MELK0.86530225
73ACVR1B0.86413914
74PDK20.84038305
75MTOR0.83932838
76SYK0.83899788
77SCYL20.83489280
78PIK3CG0.83197670
79PRKAA10.82315366
80DMPK0.81365439
81CDK40.81071475
82MAP2K30.80335702
83LYN0.78354316
84MAPK70.77847770
85NLK0.77173688
86CDK90.77151566
87LRRK20.76869874
88ABL20.76710554
89CAMKK20.75488795
90CSF1R0.74170569
91MARK20.73700459
92CDC70.72526583
93CAMK1D0.71597787
94FLT30.70553367
95MAP3K120.69610086
96MAP3K70.69061446
97GSK3A0.66720005
98RPS6KA40.66301793
99MAP2K20.65820197
100LMTK20.65286837
101WNK30.64852818
102NUAK10.64324215
103SGK30.63636861
104BMX0.63229065
105JAK10.60968599
106DYRK30.60685331
107TBK10.60669563
108TEC0.60584647
109CHEK20.60288023
110PIM10.58491453
111ERBB20.58356575
112PDGFRB0.56572690
113LCK0.56048936
114PTK20.55450809
115AURKB0.54707056
116MOS0.54613111
117SMG10.54379120
118FGFR30.54295177
119ERBB30.54085634
120PDPK10.53903049
121RET0.51389538
122PDK10.50560050
123STK380.50217233
124SIK20.49195771
125FYN0.48848587
126PRKCI0.47765354
127SGK2230.47385837
128SGK4940.47385837
129DYRK1B0.47353897
130CDK70.47303335
131MAP3K50.47105955
132CSNK1D0.46557860
133BCR0.46468250
134PDGFRA0.44282771
135ITK0.44268043
136FGFR20.44078908
137STK40.44028801
138ICK0.43554473
139STK110.43436163
140NEK90.42827996
141EPHB10.42122254
142AKT20.41634426
143NEK10.39693977
144PBK0.39689586
145TGFBR20.38985551
146ABL10.38368341
147PDK40.38344924
148PDK30.38344924
149MAP2K40.36821042
150FER0.36782293
151RAF10.34787885
152CSK0.34329806
153PRKG20.33437184
154CHEK10.32397812

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.77088100
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.57401855
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54890854
4Arginine biosynthesis_Homo sapiens_hsa002203.08360304
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70458414
6Tryptophan metabolism_Homo sapiens_hsa003802.49310178
7Leishmaniasis_Homo sapiens_hsa051402.30728328
8Osteoclast differentiation_Homo sapiens_hsa043802.29797313
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27050763
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23098006
11Fatty acid degradation_Homo sapiens_hsa000712.15181457
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14436446
13Complement and coagulation cascades_Homo sapiens_hsa046102.07281388
14Caffeine metabolism_Homo sapiens_hsa002322.01752122
15Histidine metabolism_Homo sapiens_hsa003402.01375821
16B cell receptor signaling pathway_Homo sapiens_hsa046621.97438122
17Sulfur metabolism_Homo sapiens_hsa009201.94405669
18Selenocompound metabolism_Homo sapiens_hsa004501.92495214
19Fat digestion and absorption_Homo sapiens_hsa049751.92222310
20Bile secretion_Homo sapiens_hsa049761.90928567
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90699346
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90233452
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87744623
24Tuberculosis_Homo sapiens_hsa051521.83492299
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76726920
26Legionellosis_Homo sapiens_hsa051341.74275561
27Butanoate metabolism_Homo sapiens_hsa006501.69999167
28PPAR signaling pathway_Homo sapiens_hsa033201.69744403
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67543344
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64569667
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64090591
32Phototransduction_Homo sapiens_hsa047441.61566314
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.60610788
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60591124
35Peroxisome_Homo sapiens_hsa041461.60325727
36Chemical carcinogenesis_Homo sapiens_hsa052041.60190547
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59205755
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.59155601
39Retinol metabolism_Homo sapiens_hsa008301.57759101
40Starch and sucrose metabolism_Homo sapiens_hsa005001.56287314
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55282453
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55102216
43Dorso-ventral axis formation_Homo sapiens_hsa043201.53996174
44Vitamin digestion and absorption_Homo sapiens_hsa049771.53758115
45Renal cell carcinoma_Homo sapiens_hsa052111.53380851
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.53054840
47Pancreatic cancer_Homo sapiens_hsa052121.52728584
48beta-Alanine metabolism_Homo sapiens_hsa004101.51426313
49Non-small cell lung cancer_Homo sapiens_hsa052231.47488045
50Staphylococcus aureus infection_Homo sapiens_hsa051501.46134204
51Acute myeloid leukemia_Homo sapiens_hsa052211.42076021
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.40690950
53Chronic myeloid leukemia_Homo sapiens_hsa052201.40264359
54Measles_Homo sapiens_hsa051621.39638356
55Folate biosynthesis_Homo sapiens_hsa007901.38982176
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38959184
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35209065
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35003776
59Chemokine signaling pathway_Homo sapiens_hsa040621.34929532
60Propanoate metabolism_Homo sapiens_hsa006401.34620008
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34123513
62TNF signaling pathway_Homo sapiens_hsa046681.32751705
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.31637209
64Influenza A_Homo sapiens_hsa051641.31299177
65ABC transporters_Homo sapiens_hsa020101.31039607
66Lysine degradation_Homo sapiens_hsa003101.30321320
67Toxoplasmosis_Homo sapiens_hsa051451.30217756
68Endometrial cancer_Homo sapiens_hsa052131.27774544
69Hepatitis B_Homo sapiens_hsa051611.26401375
70Prolactin signaling pathway_Homo sapiens_hsa049171.25882970
71Phenylalanine metabolism_Homo sapiens_hsa003601.25090549
72Biosynthesis of amino acids_Homo sapiens_hsa012301.24956111
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.24302713
74Fatty acid metabolism_Homo sapiens_hsa012121.23625398
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.22640421
76T cell receptor signaling pathway_Homo sapiens_hsa046601.18924972
77Malaria_Homo sapiens_hsa051441.18066080
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16245758
79Jak-STAT signaling pathway_Homo sapiens_hsa046301.13668383
80Platelet activation_Homo sapiens_hsa046111.09609911
81Neurotrophin signaling pathway_Homo sapiens_hsa047221.09402021
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07534061
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05985204
84Carbon metabolism_Homo sapiens_hsa012001.04064949
85Phagosome_Homo sapiens_hsa041451.03850880
86Pyruvate metabolism_Homo sapiens_hsa006201.01797038
87Salmonella infection_Homo sapiens_hsa051321.01072477
88Tyrosine metabolism_Homo sapiens_hsa003501.00636867
89Apoptosis_Homo sapiens_hsa042100.99395977
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98840250
91* Inositol phosphate metabolism_Homo sapiens_hsa005620.97590188
92Pertussis_Homo sapiens_hsa051330.97333394
93Arginine and proline metabolism_Homo sapiens_hsa003300.96412435
94VEGF signaling pathway_Homo sapiens_hsa043700.94795671
95ErbB signaling pathway_Homo sapiens_hsa040120.94421077
96Pentose phosphate pathway_Homo sapiens_hsa000300.93634366
97Hematopoietic cell lineage_Homo sapiens_hsa046400.93473373
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.93281144
99Glycerolipid metabolism_Homo sapiens_hsa005610.92034740
100* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90607956
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88797808
102One carbon pool by folate_Homo sapiens_hsa006700.87268112
103Renin-angiotensin system_Homo sapiens_hsa046140.85380700
104Prostate cancer_Homo sapiens_hsa052150.85276547
105Mineral absorption_Homo sapiens_hsa049780.85072316
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83279451
107Colorectal cancer_Homo sapiens_hsa052100.82755840
108Steroid biosynthesis_Homo sapiens_hsa001000.82510428
109Herpes simplex infection_Homo sapiens_hsa051680.81738818
110Shigellosis_Homo sapiens_hsa051310.81455833
111Glutathione metabolism_Homo sapiens_hsa004800.80817971
112Choline metabolism in cancer_Homo sapiens_hsa052310.77419517
113HIF-1 signaling pathway_Homo sapiens_hsa040660.76757053
114GnRH signaling pathway_Homo sapiens_hsa049120.76689863
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72216785
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68684467
117Galactose metabolism_Homo sapiens_hsa000520.66161780
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.66008491
119Vitamin B6 metabolism_Homo sapiens_hsa007500.65797424
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65063733
121Viral carcinogenesis_Homo sapiens_hsa052030.64808740
122Type II diabetes mellitus_Homo sapiens_hsa049300.64375378
123African trypanosomiasis_Homo sapiens_hsa051430.64365087
124Fructose and mannose metabolism_Homo sapiens_hsa000510.64324697
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63997618
126Proteoglycans in cancer_Homo sapiens_hsa052050.63069147
127Endocytosis_Homo sapiens_hsa041440.62976742
128Notch signaling pathway_Homo sapiens_hsa043300.62625619
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62327113
130Graft-versus-host disease_Homo sapiens_hsa053320.62070055
131Antigen processing and presentation_Homo sapiens_hsa046120.60614445
132Estrogen signaling pathway_Homo sapiens_hsa049150.60560944
133Long-term potentiation_Homo sapiens_hsa047200.59686806
134Sulfur relay system_Homo sapiens_hsa041220.58758366
135Lysosome_Homo sapiens_hsa041420.58587237
136Glioma_Homo sapiens_hsa052140.57548670
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57301368
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56522595
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54939000
140Sphingolipid metabolism_Homo sapiens_hsa006000.51999464
141Long-term depression_Homo sapiens_hsa047300.51215673
142Insulin resistance_Homo sapiens_hsa049310.49997017
143Rap1 signaling pathway_Homo sapiens_hsa040150.49002813
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47975734
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47255093
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46862163
147Other glycan degradation_Homo sapiens_hsa005110.46412600
148Allograft rejection_Homo sapiens_hsa053300.46253985
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42805125
150Linoleic acid metabolism_Homo sapiens_hsa005910.41851814
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41433780
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.35996847
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33800207
154Bladder cancer_Homo sapiens_hsa052190.29393172
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.24804948
156* Metabolic pathways_Homo sapiens_hsa011000.24230369
157Fatty acid elongation_Homo sapiens_hsa000620.23135655
158Protein digestion and absorption_Homo sapiens_hsa049740.21340922
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19369560
160AMPK signaling pathway_Homo sapiens_hsa041520.19220449
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.15306058
162Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14814289
163Hepatitis C_Homo sapiens_hsa051600.14687446
164Fatty acid biosynthesis_Homo sapiens_hsa000610.14461413
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12551667
166Adherens junction_Homo sapiens_hsa045200.11980901
167Glucagon signaling pathway_Homo sapiens_hsa049220.11913518
168mTOR signaling pathway_Homo sapiens_hsa041500.09734080
169Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09715797
170Thyroid cancer_Homo sapiens_hsa052160.08888133
171Small cell lung cancer_Homo sapiens_hsa052220.06037003
172Thyroid hormone synthesis_Homo sapiens_hsa049180.05063591
173Amoebiasis_Homo sapiens_hsa051460.03768953
174MicroRNAs in cancer_Homo sapiens_hsa052060.03139501
175Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02884780
176Systemic lupus erythematosus_Homo sapiens_hsa053220.02558234
177Insulin signaling pathway_Homo sapiens_hsa049100.01021471
178FoxO signaling pathway_Homo sapiens_hsa040680.00904162

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