

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | axon ensheathment in central nervous system (GO:0032291) | 4.98127442 |
| 2 | central nervous system myelination (GO:0022010) | 4.98127442 |
| 3 | muscle filament sliding (GO:0030049) | 4.41385075 |
| 4 | actin-myosin filament sliding (GO:0033275) | 4.41385075 |
| 5 | creatine metabolic process (GO:0006600) | 4.35238473 |
| 6 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.31312934 |
| 7 | plasma membrane repair (GO:0001778) | 4.26988734 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.03587673 |
| 9 | regulation of skeletal muscle contraction (GO:0014819) | 3.99404179 |
| 10 | positive regulation of synapse maturation (GO:0090129) | 3.95594054 |
| 11 | neuronal action potential propagation (GO:0019227) | 3.91891518 |
| 12 | sodium ion export (GO:0071436) | 3.81659555 |
| 13 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.77210045 |
| 14 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.69690681 |
| 15 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.68428628 |
| 16 | regulation of synapse structural plasticity (GO:0051823) | 3.68204097 |
| 17 | negative regulation of protein localization to cell surface (GO:2000009) | 3.63604185 |
| 18 | axon ensheathment (GO:0008366) | 3.59385521 |
| 19 | ensheathment of neurons (GO:0007272) | 3.59385521 |
| 20 | myelination (GO:0042552) | 3.58899006 |
| 21 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.57596889 |
| 22 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.56512731 |
| 23 | cellular potassium ion homeostasis (GO:0030007) | 3.53954624 |
| 24 | potassium ion import (GO:0010107) | 3.52290227 |
| 25 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.49905137 |
| 26 | actin-mediated cell contraction (GO:0070252) | 3.48905468 |
| 27 | locomotory exploration behavior (GO:0035641) | 3.46280213 |
| 28 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.45998788 |
| 29 | skeletal muscle contraction (GO:0003009) | 3.40674553 |
| 30 | sarcomere organization (GO:0045214) | 3.36877997 |
| 31 | regulation of cell communication by electrical coupling (GO:0010649) | 3.33935484 |
| 32 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.33159764 |
| 33 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.31340095 |
| 34 | NADH metabolic process (GO:0006734) | 3.29954264 |
| 35 | amino acid import (GO:0043090) | 3.29723007 |
| 36 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.26169320 |
| 37 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.21822015 |
| 38 | myofibril assembly (GO:0030239) | 3.21610418 |
| 39 | establishment of mitochondrion localization (GO:0051654) | 3.21262371 |
| 40 | negative regulation of cell size (GO:0045792) | 3.20682130 |
| 41 | membrane depolarization during action potential (GO:0086010) | 3.17411129 |
| 42 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.16020067 |
| 43 | neuromuscular junction development (GO:0007528) | 3.12628301 |
| 44 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.11949413 |
| 45 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.11949413 |
| 46 | synaptic vesicle exocytosis (GO:0016079) | 3.11017362 |
| 47 | neurotransmitter secretion (GO:0007269) | 3.10558851 |
| 48 | cell communication by electrical coupling (GO:0010644) | 3.08588614 |
| 49 | membrane tubulation (GO:0097320) | 3.08330854 |
| 50 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.07501284 |
| 51 | cerebellar granule cell differentiation (GO:0021707) | 3.07345982 |
| 52 | L-amino acid import (GO:0043092) | 3.07337345 |
| 53 | striated muscle contraction (GO:0006941) | 3.03391571 |
| 54 | regulation of ARF protein signal transduction (GO:0032012) | 3.02035133 |
| 55 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.01726019 |
| 56 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.00452743 |
| 57 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.99333688 |
| 58 | postsynaptic membrane organization (GO:0001941) | 2.99110312 |
| 59 | neuronal ion channel clustering (GO:0045161) | 2.96556618 |
| 60 | skeletal muscle fiber development (GO:0048741) | 2.95086541 |
| 61 | regulation of synapse maturation (GO:0090128) | 2.94528552 |
| 62 | cardiac muscle hypertrophy (GO:0003300) | 2.90846841 |
| 63 | activation of protein kinase A activity (GO:0034199) | 2.90558602 |
| 64 | regulation of membrane repolarization (GO:0060306) | 2.89237649 |
| 65 | potassium ion homeostasis (GO:0055075) | 2.88407517 |
| 66 | regulation of relaxation of muscle (GO:1901077) | 2.88294966 |
| 67 | glutamate secretion (GO:0014047) | 2.87575224 |
| 68 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.84125905 |
| 69 | gluconeogenesis (GO:0006094) | 2.83978931 |
| 70 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.83415532 |
| 71 | layer formation in cerebral cortex (GO:0021819) | 2.82181245 |
| 72 | positive regulation of potassium ion transport (GO:0043268) | 2.80915599 |
| 73 | dendritic spine morphogenesis (GO:0060997) | 2.80905137 |
| 74 | cardiac myofibril assembly (GO:0055003) | 2.79896323 |
| 75 | striated muscle hypertrophy (GO:0014897) | 2.76877440 |
| 76 | actin filament-based movement (GO:0030048) | 2.76602599 |
| 77 | cardiac muscle contraction (GO:0060048) | 2.74839404 |
| 78 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 2.74320730 |
| 79 | muscle hypertrophy in response to stress (GO:0003299) | 2.74320730 |
| 80 | cardiac muscle adaptation (GO:0014887) | 2.74320730 |
| 81 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.74036388 |
| 82 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.74004619 |
| 83 | response to inactivity (GO:0014854) | 2.72628798 |
| 84 | myelin maintenance (GO:0043217) | 2.71894837 |
| 85 | response to muscle activity (GO:0014850) | 2.71687785 |
| 86 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.70716474 |
| 87 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.70331922 |
| 88 | cerebellar Purkinje cell layer development (GO:0021680) | 2.69173459 |
| 89 | astrocyte development (GO:0014002) | 2.66199213 |
| 90 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.66194502 |
| 91 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 2.65563717 |
| 92 | adult walking behavior (GO:0007628) | 2.65467134 |
| 93 | vocalization behavior (GO:0071625) | 2.65333336 |
| 94 | regulation of synaptic plasticity (GO:0048167) | 2.64931938 |
| 95 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.64025233 |
| 96 | dendrite morphogenesis (GO:0048813) | 2.63575957 |
| 97 | positive regulation of myotube differentiation (GO:0010831) | 2.63384481 |
| 98 | positive regulation of dendritic spine development (GO:0060999) | 2.61850247 |
| 99 | neuromuscular synaptic transmission (GO:0007274) | 2.61447314 |
| 100 | dicarboxylic acid biosynthetic process (GO:0043650) | 2.61142072 |
| 101 | protein targeting to plasma membrane (GO:0072661) | 2.61013231 |
| 102 | actomyosin structure organization (GO:0031032) | 2.60281870 |
| 103 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.59974323 |
| 104 | skeletal muscle adaptation (GO:0043501) | 2.59562589 |
| 105 | negative regulation of inclusion body assembly (GO:0090084) | 2.58416966 |
| 106 | nerve growth factor signaling pathway (GO:0038180) | 2.58063351 |
| 107 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.57867935 |
| 108 | cell-substrate adherens junction assembly (GO:0007045) | 2.57376180 |
| 109 | focal adhesion assembly (GO:0048041) | 2.57376180 |
| 110 | hexose biosynthetic process (GO:0019319) | 2.56468913 |
| 111 | myotube cell development (GO:0014904) | 2.55772380 |
| 112 | glycogen catabolic process (GO:0005980) | 2.55164121 |
| 113 | protein localization to endosome (GO:0036010) | 2.55096754 |
| 114 | establishment of nucleus localization (GO:0040023) | 2.53616779 |
| 115 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.52689778 |
| 116 | neuromuscular process controlling balance (GO:0050885) | 2.52633297 |
| 117 | substantia nigra development (GO:0021762) | 2.52498969 |
| 118 | glycine transport (GO:0015816) | 2.52050487 |
| 119 | regulation of synaptic vesicle transport (GO:1902803) | 2.51604267 |
| 120 | regulation of actin filament-based movement (GO:1903115) | 2.51421607 |
| 121 | regulation of early endosome to late endosome transport (GO:2000641) | 2.51216282 |
| 122 | striated muscle adaptation (GO:0014888) | 2.50688023 |
| 123 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.50555031 |
| 124 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.50323498 |
| 125 | response to parathyroid hormone (GO:0071107) | 2.49400878 |
| 126 | muscle contraction (GO:0006936) | 2.48306589 |
| 127 | regulation of cation channel activity (GO:2001257) | 2.48182752 |
| 128 | mitochondrion transport along microtubule (GO:0047497) | 2.48088757 |
| 129 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.48088757 |
| 130 | transmission of nerve impulse (GO:0019226) | 2.48087822 |
| 131 | cell communication involved in cardiac conduction (GO:0086065) | 2.48029418 |
| 132 | negative regulation of axonogenesis (GO:0050771) | 2.47183181 |
| 133 | muscle system process (GO:0003012) | 2.47108185 |
| 134 | myelination in peripheral nervous system (GO:0022011) | 2.45110402 |
| 135 | peripheral nervous system axon ensheathment (GO:0032292) | 2.45110402 |
| 136 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.43268764 |
| 137 | negative regulation of microtubule polymerization (GO:0031115) | 2.42723320 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.27346343 |
| 2 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.79661584 |
| 3 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.60936913 |
| 4 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.39578249 |
| 5 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.31939525 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.30577472 |
| 7 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.24910451 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.23798171 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.23798171 |
| 10 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.23433867 |
| 11 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.21769171 |
| 12 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.17526927 |
| 13 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.12811845 |
| 14 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.11650834 |
| 15 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.05122171 |
| 16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.04464238 |
| 17 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.98957434 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.87617994 |
| 19 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.87599201 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.86567235 |
| 21 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.85431227 |
| 22 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.78598955 |
| 23 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.74519307 |
| 24 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 1.73999325 |
| 25 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.71618090 |
| 26 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.70628740 |
| 27 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.69036295 |
| 28 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.65036575 |
| 29 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.61561321 |
| 30 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.60426616 |
| 31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.59934563 |
| 32 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.59710483 |
| 33 | * DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.59479475 |
| 34 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.59130579 |
| 35 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.56224121 |
| 36 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.55440725 |
| 37 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.55111143 |
| 38 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.55060618 |
| 39 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.53301025 |
| 40 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.53273335 |
| 41 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.53224470 |
| 42 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.52938669 |
| 43 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.52641614 |
| 44 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.49102802 |
| 45 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.48150426 |
| 46 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.47284550 |
| 47 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.46897278 |
| 48 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.46409433 |
| 49 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.45867139 |
| 50 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.45276961 |
| 51 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.44974814 |
| 52 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.44321751 |
| 53 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.40066397 |
| 54 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.37947927 |
| 55 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.37124764 |
| 56 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.36789903 |
| 57 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.36720371 |
| 58 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.36701967 |
| 59 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.35841035 |
| 60 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34960414 |
| 61 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.34389438 |
| 62 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.34389438 |
| 63 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.34382799 |
| 64 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.32531199 |
| 65 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.32078567 |
| 66 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.30024312 |
| 67 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.27754264 |
| 68 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27094558 |
| 69 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.26960161 |
| 70 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.26573114 |
| 71 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24689993 |
| 72 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.21693274 |
| 73 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.21682035 |
| 74 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.20464384 |
| 75 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.20312170 |
| 76 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.19764911 |
| 77 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.19354055 |
| 78 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.17410776 |
| 79 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.17238833 |
| 80 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.17100622 |
| 81 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.16098601 |
| 82 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.15549433 |
| 83 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.15520549 |
| 84 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.14657360 |
| 85 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.14360686 |
| 86 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.11522448 |
| 87 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.11120135 |
| 88 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.10486781 |
| 89 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.10175117 |
| 90 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09491062 |
| 91 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.08615538 |
| 92 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.07721005 |
| 93 | * NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.07386190 |
| 94 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.06898994 |
| 95 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.06176405 |
| 96 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.05772983 |
| 97 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.03376233 |
| 98 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 1.02967598 |
| 99 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.02024194 |
| 100 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.01436259 |
| 101 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.01080416 |
| 102 | * MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.01065045 |
| 103 | AR_19668381_ChIP-Seq_PC3_Human | 1.01048402 |
| 104 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00357617 |
| 105 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.00337946 |
| 106 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.00235816 |
| 107 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.98539472 |
| 108 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.98377977 |
| 109 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.98170615 |
| 110 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.98018210 |
| 111 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.97330768 |
| 112 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.97308420 |
| 113 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.97303876 |
| 114 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.97203650 |
| 115 | * TP63_22573176_ChIP-Seq_HFKS_Human | 0.96791613 |
| 116 | P68_20966046_ChIP-Seq_HELA_Human | 0.96782024 |
| 117 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.96703441 |
| 118 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.96027840 |
| 119 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.95178466 |
| 120 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.94522898 |
| 121 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.94155310 |
| 122 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.91928837 |
| 123 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.91567831 |
| 124 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.90656277 |
| 125 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.90335706 |
| 126 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.90329117 |
| 127 | SA1_27219007_Chip-Seq_Bcells_Human | 0.89866535 |
| 128 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.89415422 |
| 129 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.89406740 |
| 130 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.87513565 |
| 131 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.87316927 |
| 132 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.86771188 |
| 133 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.85890876 |
| 134 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.82682438 |
| 135 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.82638891 |
| 136 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.82081289 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.41779074 |
| 2 | MP0000751_myopathy | 3.88567369 |
| 3 | MP0004145_abnormal_muscle_electrophysio | 3.87770800 |
| 4 | MP0000749_muscle_degeneration | 3.26644935 |
| 5 | MP0005451_abnormal_body_composition | 3.14433114 |
| 6 | MP0003646_muscle_fatigue | 3.12321078 |
| 7 | MP0004270_analgesia | 3.09339563 |
| 8 | MP0000747_muscle_weakness | 2.86663466 |
| 9 | MP0004036_abnormal_muscle_relaxation | 2.70734402 |
| 10 | MP0002837_dystrophic_cardiac_calcinosis | 2.59902116 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.59015986 |
| 12 | MP0003635_abnormal_synaptic_transmissio | 2.44425625 |
| 13 | MP0003880_abnormal_central_pattern | 2.35754609 |
| 14 | MP0000920_abnormal_myelination | 2.35291392 |
| 15 | MP0003329_amyloid_beta_deposits | 2.28751785 |
| 16 | MP0004233_abnormal_muscle_weight | 2.23247238 |
| 17 | MP0004087_abnormal_muscle_fiber | 2.21780919 |
| 18 | MP0000759_abnormal_skeletal_muscle | 2.13038291 |
| 19 | MP0002106_abnormal_muscle_physiology | 2.07687078 |
| 20 | MP0002064_seizures | 2.01108129 |
| 21 | MP0002269_muscular_atrophy | 2.00797295 |
| 22 | MP0003879_abnormal_hair_cell | 1.99562505 |
| 23 | MP0002272_abnormal_nervous_system | 1.93085165 |
| 24 | MP0004084_abnormal_cardiac_muscle | 1.92525463 |
| 25 | MP0009046_muscle_twitch | 1.92220076 |
| 26 | MP0008569_lethality_at_weaning | 1.86172112 |
| 27 | MP0005410_abnormal_fertilization | 1.85808660 |
| 28 | MP0005620_abnormal_muscle_contractility | 1.85583532 |
| 29 | MP0005369_muscle_phenotype | 1.82134223 |
| 30 | MP0002063_abnormal_learning/memory/cond | 1.82042894 |
| 31 | MP0004858_abnormal_nervous_system | 1.80366818 |
| 32 | MP0004130_abnormal_muscle_cell | 1.80276052 |
| 33 | MP0009745_abnormal_behavioral_response | 1.78433155 |
| 34 | MP0003950_abnormal_plasma_membrane | 1.64429602 |
| 35 | MP0001486_abnormal_startle_reflex | 1.60620642 |
| 36 | MP0004215_abnormal_myocardial_fiber | 1.58992705 |
| 37 | MP0005423_abnormal_somatic_nervous | 1.58433919 |
| 38 | MP0003690_abnormal_glial_cell | 1.55158948 |
| 39 | MP0002734_abnormal_mechanical_nocicepti | 1.54966813 |
| 40 | MP0005330_cardiomyopathy | 1.53811547 |
| 41 | MP0002822_catalepsy | 1.51428237 |
| 42 | MP0003137_abnormal_impulse_conducting | 1.49784346 |
| 43 | MP0005623_abnormal_meninges_morphology | 1.46029259 |
| 44 | MP0000750_abnormal_muscle_regeneration | 1.45485753 |
| 45 | MP0003634_abnormal_glial_cell | 1.45164138 |
| 46 | MP0008260_abnormal_autophagy | 1.44666786 |
| 47 | MP0004885_abnormal_endolymph | 1.43124424 |
| 48 | MP0000733_abnormal_muscle_development | 1.37386153 |
| 49 | MP0005670_abnormal_white_adipose | 1.37039310 |
| 50 | MP0002572_abnormal_emotion/affect_behav | 1.34512980 |
| 51 | MP0000778_abnormal_nervous_system | 1.32099684 |
| 52 | MP0001299_abnormal_eye_distance/ | 1.30825518 |
| 53 | MP0000955_abnormal_spinal_cord | 1.30101735 |
| 54 | MP0004510_myositis | 1.28415261 |
| 55 | MP0002234_abnormal_pharynx_morphology | 1.24196269 |
| 56 | MP0002108_abnormal_muscle_morphology | 1.22753178 |
| 57 | MP0002972_abnormal_cardiac_muscle | 1.21869445 |
| 58 | MP0001440_abnormal_grooming_behavior | 1.21531694 |
| 59 | MP0000579_abnormal_nail_morphology | 1.19577611 |
| 60 | MP0004811_abnormal_neuron_physiology | 1.18730700 |
| 61 | MP0005058_abnormal_lysosome_morphology | 1.17425047 |
| 62 | MP0002067_abnormal_sensory_capabilities | 1.16756030 |
| 63 | MP0002066_abnormal_motor_capabilities/c | 1.16389895 |
| 64 | MP0002882_abnormal_neuron_morphology | 1.15030005 |
| 65 | MP0001849_ear_inflammation | 1.14019014 |
| 66 | MP0002229_neurodegeneration | 1.11965352 |
| 67 | MP0005409_darkened_coat_color | 1.10828478 |
| 68 | MP0003632_abnormal_nervous_system | 1.09320727 |
| 69 | MP0001529_abnormal_vocalization | 1.08268607 |
| 70 | MP0009840_abnormal_foam_cell | 1.07524414 |
| 71 | MP0001968_abnormal_touch/_nociception | 1.06642379 |
| 72 | MP0004085_abnormal_heartbeat | 1.05707464 |
| 73 | MP0001984_abnormal_olfaction | 1.05614626 |
| 74 | MP0004924_abnormal_behavior | 1.05436818 |
| 75 | MP0005386_behavior/neurological_phenoty | 1.05436818 |
| 76 | MP0003631_nervous_system_phenotype | 1.04442465 |
| 77 | MP0003633_abnormal_nervous_system | 1.04226072 |
| 78 | MP0004185_abnormal_adipocyte_glucose | 1.02649122 |
| 79 | MP0004142_abnormal_muscle_tone | 1.01683648 |
| 80 | MP0002184_abnormal_innervation | 1.01182991 |
| 81 | MP0001348_abnormal_lacrimal_gland | 1.00869217 |
| 82 | MP0004484_altered_response_of | 1.00642400 |
| 83 | MP0003172_abnormal_lysosome_physiology | 0.99885487 |
| 84 | MP0010630_abnormal_cardiac_muscle | 0.98161627 |
| 85 | MP0001502_abnormal_circadian_rhythm | 0.97777106 |
| 86 | MP0000604_amyloidosis | 0.97301549 |
| 87 | MP0002090_abnormal_vision | 0.97184269 |
| 88 | MP0001970_abnormal_pain_threshold | 0.96828844 |
| 89 | MP0000013_abnormal_adipose_tissue | 0.96548409 |
| 90 | MP0009780_abnormal_chondrocyte_physiolo | 0.94263564 |
| 91 | MP0004043_abnormal_pH_regulation | 0.94061271 |
| 92 | MP0004742_abnormal_vestibular_system | 0.92859621 |
| 93 | MP0002249_abnormal_larynx_morphology | 0.92676753 |
| 94 | MP0008961_abnormal_basal_metabolism | 0.92611391 |
| 95 | MP0002653_abnormal_ependyma_morphology | 0.90903929 |
| 96 | MP0002733_abnormal_thermal_nociception | 0.89519079 |
| 97 | MP0008775_abnormal_heart_ventricle | 0.89046342 |
| 98 | MP0008874_decreased_physiological_sensi | 0.86735025 |
| 99 | MP0000003_abnormal_adipose_tissue | 0.85312032 |
| 100 | MP0002735_abnormal_chemical_nociception | 0.85112990 |
| 101 | MP0005375_adipose_tissue_phenotype | 0.84798177 |
| 102 | MP0001905_abnormal_dopamine_level | 0.84745058 |
| 103 | MP0008438_abnormal_cutaneous_collagen | 0.84500169 |
| 104 | MP0002152_abnormal_brain_morphology | 0.84451211 |
| 105 | MP0002736_abnormal_nociception_after | 0.83462040 |
| 106 | MP0004134_abnormal_chest_morphology | 0.82991170 |
| 107 | MP0002332_abnormal_exercise_endurance | 0.82379151 |
| 108 | MP0003075_altered_response_to | 0.78999611 |
| 109 | MP0002557_abnormal_social/conspecific_i | 0.78015900 |
| 110 | MP0002909_abnormal_adrenal_gland | 0.77974253 |
| 111 | MP0003221_abnormal_cardiomyocyte_apopto | 0.77777816 |
| 112 | MP0002971_abnormal_brown_adipose | 0.76609455 |
| 113 | MP0005666_abnormal_adipose_tissue | 0.76240184 |
| 114 | MP0005551_abnormal_eye_electrophysiolog | 0.75690145 |
| 115 | MP0006138_congestive_heart_failure | 0.75268587 |
| 116 | MP0001958_emphysema | 0.75172786 |
| 117 | MP0001544_abnormal_cardiovascular_syste | 0.72227925 |
| 118 | MP0005385_cardiovascular_system_phenoty | 0.72227925 |
| 119 | MP0001346_abnormal_lacrimal_gland | 0.69514195 |
| 120 | MP0002089_abnormal_postnatal_growth/wei | 0.68359831 |
| 121 | MP0000678_abnormal_parathyroid_gland | 0.67103901 |
| 122 | MP0006036_abnormal_mitochondrial_physio | 0.66892191 |
| 123 | MP0003123_paternal_imprinting | 0.65117774 |
| 124 | MP0003045_fibrosis | 0.64517045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 5.93921830 |
| 2 | Muscle fiber inclusion bodies (HP:0100299) | 5.53067709 |
| 3 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.30565038 |
| 4 | Exercise-induced muscle cramps (HP:0003710) | 5.14871362 |
| 5 | Nemaline bodies (HP:0003798) | 4.86812939 |
| 6 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.78942658 |
| 7 | Difficulty running (HP:0009046) | 4.58646536 |
| 8 | Type 1 muscle fiber predominance (HP:0003803) | 4.49195193 |
| 9 | Muscle fiber splitting (HP:0003555) | 4.45930565 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 4.42752567 |
| 11 | Calf muscle hypertrophy (HP:0008981) | 4.41220323 |
| 12 | Distal arthrogryposis (HP:0005684) | 3.89394393 |
| 13 | Round ear (HP:0100830) | 3.82564825 |
| 14 | EMG: myopathic abnormalities (HP:0003458) | 3.65337285 |
| 15 | Myopathic facies (HP:0002058) | 3.62047103 |
| 16 | Abnormality of the calf musculature (HP:0001430) | 3.40323933 |
| 17 | Distal lower limb muscle weakness (HP:0009053) | 3.37664515 |
| 18 | Myoglobinuria (HP:0002913) | 3.31195887 |
| 19 | Myokymia (HP:0002411) | 3.27766502 |
| 20 | Neurofibrillary tangles (HP:0002185) | 3.26807107 |
| 21 | Increased variability in muscle fiber diameter (HP:0003557) | 3.19749904 |
| 22 | Sudden death (HP:0001699) | 3.14108237 |
| 23 | Supranuclear gaze palsy (HP:0000605) | 3.12118340 |
| 24 | Muscle stiffness (HP:0003552) | 3.08952494 |
| 25 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.05612670 |
| 26 | Myotonia (HP:0002486) | 3.01155253 |
| 27 | Ankle clonus (HP:0011448) | 2.96856125 |
| 28 | Calcaneovalgus deformity (HP:0001848) | 2.93147668 |
| 29 | Increased connective tissue (HP:0009025) | 2.93029799 |
| 30 | Cerebral inclusion bodies (HP:0100314) | 2.87575912 |
| 31 | Difficulty climbing stairs (HP:0003551) | 2.70686384 |
| 32 | Deformed tarsal bones (HP:0008119) | 2.70287461 |
| 33 | Ulnar deviation of the wrist (HP:0003049) | 2.62762901 |
| 34 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.60728838 |
| 35 | Obstructive sleep apnea (HP:0002870) | 2.56494325 |
| 36 | Neck muscle weakness (HP:0000467) | 2.52839891 |
| 37 | Spastic gait (HP:0002064) | 2.51294513 |
| 38 | Focal motor seizures (HP:0011153) | 2.47231528 |
| 39 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.46880670 |
| 40 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.46880670 |
| 41 | Scapular winging (HP:0003691) | 2.44072667 |
| 42 | Bundle branch block (HP:0011710) | 2.38241528 |
| 43 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.37905652 |
| 44 | Subaortic stenosis (HP:0001682) | 2.37905652 |
| 45 | Urinary urgency (HP:0000012) | 2.37689226 |
| 46 | Lower limb amyotrophy (HP:0007210) | 2.36624347 |
| 47 | Spinal rigidity (HP:0003306) | 2.36448317 |
| 48 | Visual hallucinations (HP:0002367) | 2.33332067 |
| 49 | Action tremor (HP:0002345) | 2.30943100 |
| 50 | Insomnia (HP:0100785) | 2.30501030 |
| 51 | Gowers sign (HP:0003391) | 2.30295943 |
| 52 | Dysmetria (HP:0001310) | 2.29910124 |
| 53 | Intention tremor (HP:0002080) | 2.29311598 |
| 54 | Achilles tendon contracture (HP:0001771) | 2.27407752 |
| 55 | Focal seizures (HP:0007359) | 2.26595923 |
| 56 | Rapidly progressive (HP:0003678) | 2.26399823 |
| 57 | Bulbar palsy (HP:0001283) | 2.25949061 |
| 58 | Abnormality of the corticospinal tract (HP:0002492) | 2.24080722 |
| 59 | Rhabdomyolysis (HP:0003201) | 2.22549522 |
| 60 | Abnormal atrioventricular conduction (HP:0005150) | 2.22403805 |
| 61 | Asymmetric septal hypertrophy (HP:0001670) | 2.21659423 |
| 62 | Lower limb muscle weakness (HP:0007340) | 2.21586205 |
| 63 | Frequent falls (HP:0002359) | 2.19282583 |
| 64 | Foot dorsiflexor weakness (HP:0009027) | 2.18393335 |
| 65 | Heart block (HP:0012722) | 2.17673803 |
| 66 | Megalencephaly (HP:0001355) | 2.14475880 |
| 67 | Upper limb amyotrophy (HP:0009129) | 2.11828742 |
| 68 | Distal upper limb amyotrophy (HP:0007149) | 2.11828742 |
| 69 | Bowel incontinence (HP:0002607) | 2.11414355 |
| 70 | Abnormality of the foot musculature (HP:0001436) | 2.10923404 |
| 71 | Onion bulb formation (HP:0003383) | 2.10257110 |
| 72 | Postural instability (HP:0002172) | 2.09652186 |
| 73 | Central scotoma (HP:0000603) | 2.08170191 |
| 74 | Cerebral hypomyelination (HP:0006808) | 2.06188446 |
| 75 | Termporal pattern (HP:0011008) | 2.05018137 |
| 76 | Insidious onset (HP:0003587) | 2.05018137 |
| 77 | Broad metatarsal (HP:0001783) | 2.04253693 |
| 78 | Peripheral hypomyelination (HP:0007182) | 2.03274162 |
| 79 | Hyperacusis (HP:0010780) | 2.02193493 |
| 80 | Shoulder girdle muscle weakness (HP:0003547) | 2.02139470 |
| 81 | Slender build (HP:0001533) | 2.01587762 |
| 82 | Diplopia (HP:0000651) | 2.01325038 |
| 83 | Abnormality of binocular vision (HP:0011514) | 2.01325038 |
| 84 | Prolonged QT interval (HP:0001657) | 2.01038356 |
| 85 | Limb-girdle muscle weakness (HP:0003325) | 2.00677603 |
| 86 | Rimmed vacuoles (HP:0003805) | 2.00082583 |
| 87 | Neuronal loss in central nervous system (HP:0002529) | 1.99951986 |
| 88 | Abnormal large intestine physiology (HP:0012700) | 1.97520481 |
| 89 | Rigidity (HP:0002063) | 1.96966931 |
| 90 | Dysdiadochokinesis (HP:0002075) | 1.95989800 |
| 91 | Atrial fibrillation (HP:0005110) | 1.95555780 |
| 92 | Limb-girdle muscle atrophy (HP:0003797) | 1.95297380 |
| 93 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.95120054 |
| 94 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.95120054 |
| 95 | Dysmetric saccades (HP:0000641) | 1.94866179 |
| 96 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.94588310 |
| 97 | Absent phalangeal crease (HP:0006109) | 1.94462006 |
| 98 | Pheochromocytoma (HP:0002666) | 1.94271459 |
| 99 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.94254142 |
| 100 | Distal lower limb amyotrophy (HP:0008944) | 1.92564731 |
| 101 | Scanning speech (HP:0002168) | 1.91673351 |
| 102 | Abnormality of the Achilles tendon (HP:0005109) | 1.90692692 |
| 103 | Muscular dystrophy (HP:0003560) | 1.90566718 |
| 104 | Truncal ataxia (HP:0002078) | 1.89923088 |
| 105 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.88969934 |
| 106 | Poor eye contact (HP:0000817) | 1.88824535 |
| 107 | EMG: neuropathic changes (HP:0003445) | 1.88223020 |
| 108 | Clonus (HP:0002169) | 1.88051470 |
| 109 | Ragged-red muscle fibers (HP:0003200) | 1.87698969 |
| 110 | Depression (HP:0000716) | 1.86832270 |
| 111 | Abnormal gallbladder physiology (HP:0012438) | 1.85894404 |
| 112 | Cholecystitis (HP:0001082) | 1.85894404 |
| 113 | Fetal akinesia sequence (HP:0001989) | 1.85651869 |
| 114 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.85002213 |
| 115 | Ventricular tachycardia (HP:0004756) | 1.84761760 |
| 116 | Primary atrial arrhythmia (HP:0001692) | 1.83484973 |
| 117 | Stridor (HP:0010307) | 1.83468755 |
| 118 | Epileptic encephalopathy (HP:0200134) | 1.82453760 |
| 119 | Slow progression (HP:0003677) | 1.81784900 |
| 120 | Atrioventricular block (HP:0001678) | 1.81247333 |
| 121 | Proximal amyotrophy (HP:0007126) | 1.80725335 |
| 122 | Ventricular fibrillation (HP:0001663) | 1.79749886 |
| 123 | Bell-shaped thorax (HP:0001591) | 1.79663399 |
| 124 | Hand muscle atrophy (HP:0009130) | 1.79549306 |
| 125 | Back pain (HP:0003418) | 1.77219874 |
| 126 | Tetraplegia (HP:0002445) | 1.76306248 |
| 127 | Dilated cardiomyopathy (HP:0001644) | 1.75515231 |
| 128 | Hammertoe (HP:0001765) | 1.74795977 |
| 129 | Axonal loss (HP:0003447) | 1.73687514 |
| 130 | Ventricular arrhythmia (HP:0004308) | 1.72146736 |
| 131 | Generalized muscle weakness (HP:0003324) | 1.71184764 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 3.53680618 |
| 2 | OBSCN | 3.25460071 |
| 3 | PHKG1 | 3.24242885 |
| 4 | PHKG2 | 3.24242885 |
| 5 | STK39 | 2.77231168 |
| 6 | ICK | 2.49654627 |
| 7 | PAK6 | 2.41176490 |
| 8 | TRIB3 | 2.37836679 |
| 9 | PRKD3 | 2.37008081 |
| 10 | EPHB1 | 2.16182772 |
| 11 | MAP3K9 | 2.10090744 |
| 12 | EPHA4 | 1.89403338 |
| 13 | DMPK | 1.84638978 |
| 14 | OXSR1 | 1.80621055 |
| 15 | KSR2 | 1.66949057 |
| 16 | PRPF4B | 1.65459796 |
| 17 | PDK3 | 1.57096014 |
| 18 | PDK4 | 1.57096014 |
| 19 | MARK1 | 1.55061255 |
| 20 | PINK1 | 1.53075437 |
| 21 | NTRK1 | 1.45851199 |
| 22 | CDK19 | 1.42901353 |
| 23 | WNK1 | 1.42571440 |
| 24 | TYRO3 | 1.40868235 |
| 25 | SIK2 | 1.40052130 |
| 26 | NTRK3 | 1.37201489 |
| 27 | NTRK2 | 1.35745616 |
| 28 | PNCK | 1.32740067 |
| 29 | MAP3K7 | 1.32319617 |
| 30 | MINK1 | 1.29606542 |
| 31 | WNK4 | 1.28817110 |
| 32 | SIK1 | 1.26402517 |
| 33 | NME1 | 1.24184061 |
| 34 | CAMKK1 | 1.21881952 |
| 35 | MAP3K11 | 1.18004963 |
| 36 | UHMK1 | 1.16163621 |
| 37 | NEK1 | 1.14193750 |
| 38 | PKN1 | 1.12693850 |
| 39 | DAPK2 | 1.12368841 |
| 40 | ROCK2 | 1.10647121 |
| 41 | MAP3K4 | 1.10340020 |
| 42 | EEF2K | 1.10164225 |
| 43 | LIMK1 | 1.09350457 |
| 44 | FGFR2 | 1.08253724 |
| 45 | CDK5 | 1.08206231 |
| 46 | CAMK1G | 1.08155052 |
| 47 | LMTK2 | 1.01715084 |
| 48 | MAP2K4 | 1.01335804 |
| 49 | SMG1 | 0.99162707 |
| 50 | PTK2B | 0.96361868 |
| 51 | MAPKAPK5 | 0.96323376 |
| 52 | PAK3 | 0.93776694 |
| 53 | ARAF | 0.92709993 |
| 54 | MARK2 | 0.92388864 |
| 55 | BRAF | 0.89510307 |
| 56 | RIPK1 | 0.88556194 |
| 57 | TAOK1 | 0.88429206 |
| 58 | SGK3 | 0.87447418 |
| 59 | TNIK | 0.86948634 |
| 60 | CDK15 | 0.85197596 |
| 61 | TAOK2 | 0.84692892 |
| 62 | PDK2 | 0.84617000 |
| 63 | DYRK1B | 0.83667642 |
| 64 | ERN1 | 0.82939433 |
| 65 | CAMK2D | 0.82881698 |
| 66 | CAMK1 | 0.81802326 |
| 67 | CDK14 | 0.81623396 |
| 68 | CDK18 | 0.81222578 |
| 69 | SGK223 | 0.80998013 |
| 70 | SGK494 | 0.80998013 |
| 71 | PDPK1 | 0.80746520 |
| 72 | BCR | 0.79585507 |
| 73 | RAF1 | 0.79288951 |
| 74 | MAP2K3 | 0.79220141 |
| 75 | KSR1 | 0.76582337 |
| 76 | PRKD1 | 0.76396655 |
| 77 | MOS | 0.75939072 |
| 78 | MAP3K3 | 0.75521178 |
| 79 | TESK1 | 0.74268604 |
| 80 | IRAK3 | 0.73831974 |
| 81 | RPS6KA2 | 0.73829522 |
| 82 | MAPK12 | 0.72879440 |
| 83 | CDK11A | 0.72572093 |
| 84 | CAMK2B | 0.71879488 |
| 85 | CDK12 | 0.71368043 |
| 86 | MTOR | 0.71139410 |
| 87 | MUSK | 0.70497182 |
| 88 | PRKD2 | 0.68446072 |
| 89 | MAPK10 | 0.67815110 |
| 90 | STK38 | 0.67533680 |
| 91 | CAMK2G | 0.66629435 |
| 92 | PRKCH | 0.64128215 |
| 93 | MAP3K13 | 0.63888287 |
| 94 | DDR2 | 0.63406006 |
| 95 | MET | 0.62290810 |
| 96 | AKT2 | 0.61117789 |
| 97 | STK11 | 0.60149560 |
| 98 | CAMKK2 | 0.60093263 |
| 99 | PDK1 | 0.59362517 |
| 100 | RET | 0.59307433 |
| 101 | PDGFRA | 0.59060824 |
| 102 | ROCK1 | 0.57641288 |
| 103 | PIM2 | 0.56725036 |
| 104 | ILK | 0.56531819 |
| 105 | ALK | 0.56426159 |
| 106 | CAMK2A | 0.56348387 |
| 107 | CCNB1 | 0.55808186 |
| 108 | CLK1 | 0.54871076 |
| 109 | BMX | 0.53731226 |
| 110 | NEK6 | 0.53729063 |
| 111 | DAPK3 | 0.53606356 |
| 112 | PRKAA1 | 0.53595183 |
| 113 | LATS2 | 0.53497841 |
| 114 | SGK2 | 0.51828703 |
| 115 | PIK3CG | 0.51756499 |
| 116 | CAMK4 | 0.50822316 |
| 117 | PTK2 | 0.48353768 |
| 118 | MAP2K1 | 0.47482203 |
| 119 | PKN2 | 0.46458702 |
| 120 | TESK2 | 0.45872287 |
| 121 | MAPK4 | 0.45827263 |
| 122 | TRPM7 | 0.45138472 |
| 123 | SGK1 | 0.44596836 |
| 124 | MAPKAPK3 | 0.42763736 |
| 125 | MAP2K6 | 0.42537279 |
| 126 | IRAK2 | 0.42214775 |
| 127 | FYN | 0.41832150 |
| 128 | CDC42BPA | 0.41461270 |
| 129 | FGR | 0.41354617 |
| 130 | PRKCG | 0.41056295 |
| 131 | PRKACB | 0.39511514 |
| 132 | RPS6KB1 | 0.39448395 |
| 133 | RPS6KA3 | 0.38804526 |
| 134 | MAP3K1 | 0.38584425 |
| 135 | MAPK11 | 0.37304774 |
| 136 | PRKG2 | 0.36656134 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.42528053 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.17524414 |
| 3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.14198958 |
| 4 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.08509162 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.08158678 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.00836374 |
| 7 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.98041984 |
| 8 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.97929389 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 1.93483780 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.86179138 |
| 11 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.85368783 |
| 12 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.77609649 |
| 13 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.75704109 |
| 14 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.74641447 |
| 15 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.72975087 |
| 16 | Morphine addiction_Homo sapiens_hsa05032 | 1.70403343 |
| 17 | Long-term potentiation_Homo sapiens_hsa04720 | 1.69561528 |
| 18 | Nicotine addiction_Homo sapiens_hsa05033 | 1.64270962 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.57575731 |
| 20 | Salivary secretion_Homo sapiens_hsa04970 | 1.55657064 |
| 21 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.55372438 |
| 22 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.53392120 |
| 23 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.49790247 |
| 24 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.45589683 |
| 25 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.43154145 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.40006743 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.37756346 |
| 28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.36085423 |
| 29 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.35101528 |
| 30 | Insulin secretion_Homo sapiens_hsa04911 | 1.34209411 |
| 31 | Renin secretion_Homo sapiens_hsa04924 | 1.33686949 |
| 32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.33256015 |
| 33 | Prion diseases_Homo sapiens_hsa05020 | 1.32554649 |
| 34 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.30342763 |
| 35 | Long-term depression_Homo sapiens_hsa04730 | 1.29804604 |
| 36 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.26748426 |
| 37 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.24359513 |
| 38 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.22004651 |
| 39 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.18061862 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.17755871 |
| 41 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.11230882 |
| 42 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.10127853 |
| 43 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.09532001 |
| 44 | Tight junction_Homo sapiens_hsa04530 | 1.08536038 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.03471700 |
| 46 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.02864635 |
| 47 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.01906390 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.01193093 |
| 49 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.00870289 |
| 50 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00627307 |
| 51 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.99064116 |
| 52 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.98654836 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.97602069 |
| 54 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.96984250 |
| 55 | Cocaine addiction_Homo sapiens_hsa05030 | 0.95709301 |
| 56 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.95585814 |
| 57 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.94058087 |
| 58 | Glioma_Homo sapiens_hsa05214 | 0.93971396 |
| 59 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.92174189 |
| 60 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.92141480 |
| 61 | Endocytosis_Homo sapiens_hsa04144 | 0.91881588 |
| 62 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.91395937 |
| 63 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.90838130 |
| 64 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.89707088 |
| 65 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.88314856 |
| 66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.87520481 |
| 67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.87344538 |
| 68 | Circadian rhythm_Homo sapiens_hsa04710 | 0.86054761 |
| 69 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.85154636 |
| 70 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.84487204 |
| 71 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.83555528 |
| 72 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.83534074 |
| 73 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.79640122 |
| 74 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.78729226 |
| 75 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.77405576 |
| 76 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.77391537 |
| 77 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73915934 |
| 78 | Taste transduction_Homo sapiens_hsa04742 | 0.72908545 |
| 79 | Bile secretion_Homo sapiens_hsa04976 | 0.71762877 |
| 80 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71601957 |
| 81 | Focal adhesion_Homo sapiens_hsa04510 | 0.70459951 |
| 82 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70383777 |
| 83 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.69928247 |
| 84 | Endometrial cancer_Homo sapiens_hsa05213 | 0.69725053 |
| 85 | Melanogenesis_Homo sapiens_hsa04916 | 0.68979937 |
| 86 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.68749569 |
| 87 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.68412371 |
| 88 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.67783840 |
| 89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.67709908 |
| 90 | Galactose metabolism_Homo sapiens_hsa00052 | 0.67281411 |
| 91 | Other glycan degradation_Homo sapiens_hsa00511 | 0.67007267 |
| 92 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.66986987 |
| 93 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.66089022 |
| 94 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.65975937 |
| 95 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.64396127 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.63621036 |
| 97 | Carbon metabolism_Homo sapiens_hsa01200 | 0.63181750 |
| 98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.62159118 |
| 99 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.60534840 |
| 100 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.59742010 |
| 101 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.57911570 |
| 102 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.57226473 |
| 103 | Alzheimers disease_Homo sapiens_hsa05010 | 0.56093125 |
| 104 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.55608787 |
| 105 | Insulin resistance_Homo sapiens_hsa04931 | 0.55568111 |
| 106 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.54606946 |
| 107 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.54526816 |
| 108 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.54191629 |
| 109 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.53508414 |
| 110 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.53055890 |
| 111 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.52263803 |
| 112 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.51989427 |
| 113 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.51582144 |
| 114 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.50769134 |
| 115 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.50735691 |
| 116 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.50500076 |
| 117 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.48173404 |
| 118 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47737743 |
| 119 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46198507 |
| 120 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.45646584 |
| 121 | Bladder cancer_Homo sapiens_hsa05219 | 0.45035874 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.44970908 |

