IPO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.86991717
2nuclear pore complex assembly (GO:0051292)5.80007891
3DNA unwinding involved in DNA replication (GO:0006268)4.89141967
4protein localization to kinetochore (GO:0034501)4.62695186
5mitotic nuclear envelope disassembly (GO:0007077)4.58338783
6establishment of integrated proviral latency (GO:0075713)4.53453990
7DNA replication-dependent nucleosome organization (GO:0034723)4.37420716
8DNA replication-dependent nucleosome assembly (GO:0006335)4.37420716
9membrane disassembly (GO:0030397)4.33467002
10nuclear envelope disassembly (GO:0051081)4.33467002
11pore complex assembly (GO:0046931)4.32129018
12protein localization to chromosome, centromeric region (GO:0071459)4.28196913
13mitotic sister chromatid cohesion (GO:0007064)4.25462631
14pre-miRNA processing (GO:0031054)4.19648675
15IMP biosynthetic process (GO:0006188)4.10278285
16nucleobase biosynthetic process (GO:0046112)4.05789573
17heterochromatin organization (GO:0070828)4.04979547
18mitotic metaphase plate congression (GO:0007080)4.02654939
19folic acid-containing compound biosynthetic process (GO:0009396)4.02205544
20DNA replication initiation (GO:0006270)3.99570991
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.96818490
22regulation of spindle organization (GO:0090224)3.90658905
23mitotic sister chromatid segregation (GO:0000070)3.80366563
24protein complex localization (GO:0031503)3.78747422
25sister chromatid segregation (GO:0000819)3.76628807
26regulation of translational termination (GO:0006449)3.76276068
27telomere maintenance via semi-conservative replication (GO:0032201)3.73423857
28positive regulation of chromosome segregation (GO:0051984)3.72243445
29purine nucleobase biosynthetic process (GO:0009113)3.71195475
30DNA strand elongation involved in DNA replication (GO:0006271)3.67816462
31mitotic chromosome condensation (GO:0007076)3.61903018
32DNA duplex unwinding (GO:0032508)3.61073621
33double-strand break repair via nonhomologous end joining (GO:0006303)3.60414967
34non-recombinational repair (GO:0000726)3.60414967
35formation of translation preinitiation complex (GO:0001731)3.60298671
36DNA geometric change (GO:0032392)3.60262547
37ribosome assembly (GO:0042255)3.59739737
38regulation of histone H3-K9 methylation (GO:0051570)3.58674596
39regulation of posttranscriptional gene silencing (GO:0060147)3.57516445
40regulation of gene silencing by miRNA (GO:0060964)3.57516445
41regulation of gene silencing by RNA (GO:0060966)3.57516445
42IMP metabolic process (GO:0046040)3.57176648
43chaperone-mediated protein complex assembly (GO:0051131)3.54764352
44regulation of centriole replication (GO:0046599)3.54512974
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51527527
46cellular protein complex localization (GO:0034629)3.50172514
47regulation of translational fidelity (GO:0006450)3.48934893
48DNA strand elongation (GO:0022616)3.46808590
49chromosome condensation (GO:0030261)3.45990951
50metaphase plate congression (GO:0051310)3.45783731
51regulation of RNA export from nucleus (GO:0046831)3.45061778
52nuclear envelope organization (GO:0006998)3.43670632
53regulation of chromosome segregation (GO:0051983)3.42417538
54DNA topological change (GO:0006265)3.41651223
55regulation of centrosome cycle (GO:0046605)3.39896156
56regulation of mitotic spindle organization (GO:0060236)3.37271415
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.34937159
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34937159
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34937159
60CENP-A containing nucleosome assembly (GO:0034080)3.34419444
61regulation of sister chromatid cohesion (GO:0007063)3.32512817
62monoubiquitinated protein deubiquitination (GO:0035520)3.31774988
63negative regulation of histone methylation (GO:0031061)3.30427801
64mitotic recombination (GO:0006312)3.28862097
65binding of sperm to zona pellucida (GO:0007339)3.26673437
66translesion synthesis (GO:0019985)3.25429260
67chromatin assembly (GO:0031497)3.24628478
68histone H2A monoubiquitination (GO:0035518)3.23046245
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.22588451
70somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22588451
71DNA replication checkpoint (GO:0000076)3.21851210
72establishment of viral latency (GO:0019043)3.20975680
73microtubule depolymerization (GO:0007019)3.20470705
74protein localization to chromosome (GO:0034502)3.19743684
75telomere maintenance via recombination (GO:0000722)3.19704736
76paraxial mesoderm development (GO:0048339)3.18706426
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17902270
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.17810095
79DNA conformation change (GO:0071103)3.16678415
80sperm-egg recognition (GO:0035036)3.16251033
81histone exchange (GO:0043486)3.16120767
82peptidyl-arginine omega-N-methylation (GO:0035247)3.15143661
83DNA packaging (GO:0006323)3.14238818
84negative regulation of chromosome segregation (GO:0051985)3.12092004
85ATP-dependent chromatin remodeling (GO:0043044)3.10613977
86negative regulation of DNA repair (GO:0045738)3.09079115
87ribosome biogenesis (GO:0042254)3.08039353
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07753243
89chromatin assembly or disassembly (GO:0006333)3.07300853
90L-serine metabolic process (GO:0006563)3.06099152
91notochord development (GO:0030903)3.05790277
92DNA synthesis involved in DNA repair (GO:0000731)3.05649700
93gene silencing by RNA (GO:0031047)3.05230532
94dosage compensation (GO:0007549)3.04703278
95establishment of chromosome localization (GO:0051303)3.04553970
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.03736334
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03736334
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03736334
99negative regulation of sister chromatid segregation (GO:0033046)3.03736334
100mRNA stabilization (GO:0048255)3.02957574
101RNA stabilization (GO:0043489)3.02957574
102DNA ligation (GO:0006266)3.02350134
103attachment of spindle microtubules to kinetochore (GO:0008608)2.99829965
104DNA replication-independent nucleosome organization (GO:0034724)2.99357870
105DNA replication-independent nucleosome assembly (GO:0006336)2.99357870
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99218512
107chromatin remodeling at centromere (GO:0031055)2.99161581
108spindle checkpoint (GO:0031577)2.97277211
109mitotic spindle checkpoint (GO:0071174)2.96067619
110postreplication repair (GO:0006301)2.94131553
111spindle assembly checkpoint (GO:0071173)2.93252107
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92809533
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92110055
114mitotic spindle assembly checkpoint (GO:0007094)2.91956132
115regulation of sister chromatid segregation (GO:0033045)2.90859978
116regulation of mitotic sister chromatid segregation (GO:0033047)2.90859978
117regulation of mitotic sister chromatid separation (GO:0010965)2.89754635
118glutamine metabolic process (GO:0006541)2.77345356
119nucleosome disassembly (GO:0006337)2.74994746
120protein-DNA complex disassembly (GO:0032986)2.74994746
121kinetochore organization (GO:0051383)2.74289165
122positive regulation of SMAD protein import into nucleus (GO:0060391)2.69585695
123regulation of helicase activity (GO:0051095)2.67903485
124chromosome segregation (GO:0007059)2.67417185
125regulation of centrosome duplication (GO:0010824)2.66196872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81268481
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.35261654
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.12034420
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.00913484
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81789259
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21504656
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12159148
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09163611
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.76056838
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61337011
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61235095
12AR_21909140_ChIP-Seq_LNCAP_Human2.52209625
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32027915
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18561565
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.18350148
16MYC_22102868_ChIP-Seq_BL_Human2.09719717
17XRN2_22483619_ChIP-Seq_HELA_Human2.08672255
18MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02289711
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93323375
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88817476
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86212863
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.84503489
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83704123
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.82849478
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.74276731
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71325609
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64110080
28* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63177184
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63168729
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62568118
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62452618
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57720401
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53076172
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52348635
35TTF2_22483619_ChIP-Seq_HELA_Human1.49998468
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49917644
37KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48950353
38* KDM5A_27292631_Chip-Seq_BREAST_Human1.47549253
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47326670
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46122211
41VDR_23849224_ChIP-Seq_CD4+_Human1.45291101
42GABP_19822575_ChIP-Seq_HepG2_Human1.45151373
43FOXP3_21729870_ChIP-Seq_TREG_Human1.41798545
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41189823
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41145891
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38046886
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37885126
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35253120
49CIITA_25753668_ChIP-Seq_RAJI_Human1.33664849
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33468733
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32610527
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31967087
53DCP1A_22483619_ChIP-Seq_HELA_Human1.31620459
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30431455
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.29989864
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.29953788
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29380155
58ZNF263_19887448_ChIP-Seq_K562_Human1.27852914
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.27657074
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.27179506
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24355016
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.24048302
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23555547
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.22057459
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21782549
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.21769210
67CLOCK_20551151_ChIP-Seq_293T_Human1.17860528
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17163139
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15142402
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13069938
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12304024
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11926803
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11564275
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10181880
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10102528
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10005808
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07971045
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07971045
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07971045
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07012174
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06887334
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06053631
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05946288
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04432712
85TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03749580
86TFEB_21752829_ChIP-Seq_HELA_Human1.03528178
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03421835
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00713917
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97494905
90ELK1_19687146_ChIP-ChIP_HELA_Human0.97232266
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97135758
92CHD1_26751641_Chip-Seq_LNCaP_Human0.94022699
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93033336
94TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89464693
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88360866
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88113060
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85665182
98ATF3_27146783_Chip-Seq_COLON_Human0.85319636
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84989412
100* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84907121
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84801169
102YY1_21170310_ChIP-Seq_MESCs_Mouse0.83944613
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83498503
104PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83412660
105SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82258294
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81990609
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81357879
108VDR_21846776_ChIP-Seq_THP-1_Human0.80188557
109* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79745986
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79576290
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79064580
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78553051
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77626751
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.77377643
115MYC_18940864_ChIP-ChIP_HL60_Human0.76814414
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76737456
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76280939
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75867125
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75459371
120POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75087995
121TCF7_22412390_ChIP-Seq_EML_Mouse0.74831329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.09812390
2MP0003111_abnormal_nucleus_morphology4.00731087
3MP0003693_abnormal_embryo_hatching3.94493814
4MP0004957_abnormal_blastocyst_morpholog3.70615684
5MP0003077_abnormal_cell_cycle3.33660817
6MP0008057_abnormal_DNA_replication3.10102644
7MP0010352_gastrointestinal_tract_polyps2.96636737
8MP0003123_paternal_imprinting2.79813618
9MP0001730_embryonic_growth_arrest2.69895532
10MP0008877_abnormal_DNA_methylation2.58302538
11MP0005410_abnormal_fertilization2.57578198
12MP0003705_abnormal_hypodermis_morpholog2.51057836
13MP0010307_abnormal_tumor_latency2.45701174
14MP0008058_abnormal_DNA_repair2.45199378
15MP0008007_abnormal_cellular_replicative2.37825217
16MP0000350_abnormal_cell_proliferation2.25201933
17MP0008932_abnormal_embryonic_tissue2.15319379
18MP0005076_abnormal_cell_differentiation2.14893487
19MP0001672_abnormal_embryogenesis/_devel2.14856508
20MP0005380_embryogenesis_phenotype2.14856508
21MP0002084_abnormal_developmental_patter2.03443957
22MP0001697_abnormal_embryo_size2.01108383
23MP0003984_embryonic_growth_retardation1.98104522
24MP0004197_abnormal_fetal_growth/weight/1.97134727
25MP0002088_abnormal_embryonic_growth/wei1.95350430
26MP0002085_abnormal_embryonic_tissue1.88585020
27MP0009697_abnormal_copulation1.88208492
28MP0000537_abnormal_urethra_morphology1.81477077
29MP0002653_abnormal_ependyma_morphology1.81258175
30MP0002086_abnormal_extraembryonic_tissu1.77247327
31MP0002080_prenatal_lethality1.76078946
32MP0001929_abnormal_gametogenesis1.62708140
33MP0003567_abnormal_fetal_cardiomyocyte1.60859363
34MP0003121_genomic_imprinting1.60266739
35MP0010030_abnormal_orbit_morphology1.58395576
36MP0004272_abnormal_basement_membrane1.58228331
37MP0004233_abnormal_muscle_weight1.55082687
38MP0001299_abnormal_eye_distance/1.54161636
39MP0002210_abnormal_sex_determination1.51198654
40MP0002009_preneoplasia1.51091924
41MP0002396_abnormal_hematopoietic_system1.48792995
42MP0001293_anophthalmia1.48518484
43MP0003890_abnormal_embryonic-extraembry1.46313760
44MP0009053_abnormal_anal_canal1.44757628
45MP0005623_abnormal_meninges_morphology1.42549537
46MP0008438_abnormal_cutaneous_collagen1.41305924
47MP0009672_abnormal_birth_weight1.39277867
48MP0003119_abnormal_digestive_system1.38365202
49MP0003698_abnormal_male_reproductive1.37120761
50MP0004808_abnormal_hematopoietic_stem1.36927207
51MP0001145_abnormal_male_reproductive1.35498537
52MP0003786_premature_aging1.32614198
53MP0006292_abnormal_olfactory_placode1.31527702
54MP0001661_extended_life_span1.30946665
55MP0003385_abnormal_body_wall1.29688512
56MP0000733_abnormal_muscle_development1.22630820
57MP0003566_abnormal_cell_adhesion1.21706596
58MP0000313_abnormal_cell_death1.18978209
59MP0002233_abnormal_nose_morphology1.18953048
60MP0000428_abnormal_craniofacial_morphol1.15112079
61MP0009703_decreased_birth_body1.13125550
62MP0004084_abnormal_cardiac_muscle1.12962658
63MP0005257_abnormal_intraocular_pressure1.12135968
64MP0001849_ear_inflammation1.11629698
65MP0003115_abnormal_respiratory_system1.10518364
66MP0000653_abnormal_sex_gland1.10379344
67MP0000566_synostosis1.10324204
68MP0002938_white_spotting1.09550281
69MP0003941_abnormal_skin_development1.07206081
70MP0003937_abnormal_limbs/digits/tail_de1.07119396
71MP0002092_abnormal_eye_morphology1.05132785
72MP0001346_abnormal_lacrimal_gland1.05051457
73MP0003942_abnormal_urinary_system1.04724248
74MP0002697_abnormal_eye_size1.03594267
75MP0003221_abnormal_cardiomyocyte_apopto1.00632108
76MP0002019_abnormal_tumor_incidence1.00560341
77MP0000762_abnormal_tongue_morphology0.98335724
78MP0000579_abnormal_nail_morphology0.97115306
79MP0000490_abnormal_crypts_of0.95111208
80MP0002161_abnormal_fertility/fecundity0.95085091
81MP0001915_intracranial_hemorrhage0.95018320
82MP0002111_abnormal_tail_morphology0.93968000
83MP0009278_abnormal_bone_marrow0.92770969
84MP0005023_abnormal_wound_healing0.91791434
85MP0002160_abnormal_reproductive_system0.89650731
86MP0003283_abnormal_digestive_organ0.85903073
87MP0002269_muscular_atrophy0.85549279
88MP0002925_abnormal_cardiovascular_devel0.85528209
89MP0010234_abnormal_vibrissa_follicle0.83989186
90MP0000432_abnormal_head_morphology0.83637781
91MP0003935_abnormal_craniofacial_develop0.83591798
92MP0000358_abnormal_cell_content/0.83525043
93MP0000049_abnormal_middle_ear0.82772262
94MP0003861_abnormal_nervous_system0.82497798
95MP0000750_abnormal_muscle_regeneration0.82319783
96MP0003950_abnormal_plasma_membrane0.81037176
97MP0009250_abnormal_appendicular_skeleto0.80958423
98MP0002081_perinatal_lethality0.78332551
99MP0005384_cellular_phenotype0.77775195
100MP0002877_abnormal_melanocyte_morpholog0.77433048
101MP0010630_abnormal_cardiac_muscle0.76776916
102MP0002282_abnormal_trachea_morphology0.76633278
103MP0004133_heterotaxia0.75676753
104MP0000266_abnormal_heart_morphology0.74911093
105MP0005621_abnormal_cell_physiology0.74695502
106MP0002060_abnormal_skin_morphology0.74363334
107MP0000751_myopathy0.74335302
108MP0008770_decreased_survivor_rate0.74151988
109MP0003315_abnormal_perineum_morphology0.73157241
110MP0004264_abnormal_extraembryonic_tissu0.72613124
111MP0002116_abnormal_craniofacial_bone0.70916887
112MP0001286_abnormal_eye_development0.70579074
113MP0003718_maternal_effect0.69747008
114MP0000703_abnormal_thymus_morphology0.67991566
115MP0005397_hematopoietic_system_phenotyp0.67983766
116MP0001545_abnormal_hematopoietic_system0.67983766
117MP0002254_reproductive_system_inflammat0.67160324
118MP0005187_abnormal_penis_morphology0.66896442
119MP0004185_abnormal_adipocyte_glucose0.62666301
120MP0000534_abnormal_ureter_morphology0.62655684
121MP0002114_abnormal_axial_skeleton0.60984850
122MP0006054_spinal_hemorrhage0.60885527
123MP0003755_abnormal_palate_morphology0.60365348
124MP0004087_abnormal_muscle_fiber0.57702801

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.55554236
2Medulloblastoma (HP:0002885)3.65351381
3Selective tooth agenesis (HP:0001592)3.61807883
4Abnormality of the astrocytes (HP:0100707)3.44252853
5Astrocytoma (HP:0009592)3.44252853
6Impulsivity (HP:0100710)3.30337245
7Birth length less than 3rd percentile (HP:0003561)3.06340831
8Glioma (HP:0009733)2.93867084
9Short 4th metacarpal (HP:0010044)2.87095335
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87095335
11Deviation of the thumb (HP:0009603)2.84135115
12Agnosia (HP:0010524)2.82206522
13Rhabdomyosarcoma (HP:0002859)2.81405661
14Proximal placement of thumb (HP:0009623)2.81019794
15Colon cancer (HP:0003003)2.79927651
16Increased nuchal translucency (HP:0010880)2.75711346
17Nephroblastoma (Wilms tumor) (HP:0002667)2.75693814
18Cortical dysplasia (HP:0002539)2.75653992
19Abnormality of the anterior horn cell (HP:0006802)2.75180709
20Degeneration of anterior horn cells (HP:0002398)2.75180709
21Abnormality of the labia minora (HP:0012880)2.73071837
22Embryonal renal neoplasm (HP:0011794)2.64794222
23Neoplasm of striated muscle (HP:0009728)2.52514227
24Biliary tract neoplasm (HP:0100574)2.51093102
25Missing ribs (HP:0000921)2.43910194
26Neoplasm of the oral cavity (HP:0100649)2.40442345
27Basal cell carcinoma (HP:0002671)2.35469995
28Hepatoblastoma (HP:0002884)2.31889509
29High anterior hairline (HP:0009890)2.27256270
30Chromsome breakage (HP:0040012)2.27062360
31Pelvic girdle muscle weakness (HP:0003749)2.23897771
32Abnormality of chromosome stability (HP:0003220)2.23254391
33Patellar aplasia (HP:0006443)2.22355275
34Aplasia/hypoplasia of the humerus (HP:0006507)2.21828850
35Abnormality of the lower motor neuron (HP:0002366)2.21560724
36Abnormality of the calcaneus (HP:0008364)2.21251863
37High pitched voice (HP:0001620)2.20455953
38Short humerus (HP:0005792)2.19680877
39Volvulus (HP:0002580)2.18803759
40Breast hypoplasia (HP:0003187)2.18474503
41Premature rupture of membranes (HP:0001788)2.17897770
42Supernumerary spleens (HP:0009799)2.17850306
43Abnormality of the 4th metacarpal (HP:0010012)2.15935965
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15572191
45Abnormal lung lobation (HP:0002101)2.14696030
46Aplasia/Hypoplasia of the patella (HP:0006498)2.12304562
47Overriding aorta (HP:0002623)2.11208446
48Calcaneovalgus deformity (HP:0001848)2.10936133
49Spastic diplegia (HP:0001264)2.10695520
50Neoplasm of the pancreas (HP:0002894)2.08355979
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08029577
52Absent radius (HP:0003974)2.07760887
53Abnormal number of incisors (HP:0011064)2.07471426
54Atresia of the external auditory canal (HP:0000413)2.06733684
55Reticulocytopenia (HP:0001896)2.06690753
56Heterotopia (HP:0002282)2.05842408
57Prominent nose (HP:0000448)2.04408755
58Insomnia (HP:0100785)2.04152046
59Meckel diverticulum (HP:0002245)2.03822612
60Duplication of thumb phalanx (HP:0009942)2.03731906
61Ectopic kidney (HP:0000086)2.03559783
62Renal duplication (HP:0000075)2.02154434
63Shoulder girdle muscle weakness (HP:0003547)2.00834142
64Carpal bone hypoplasia (HP:0001498)1.97028247
65Deep philtrum (HP:0002002)1.96377138
66Cafe-au-lait spot (HP:0000957)1.96353431
67Hyperacusis (HP:0010780)1.95178992
68Aplasia/Hypoplasia of the uvula (HP:0010293)1.94046208
69Malignant gastrointestinal tract tumors (HP:0006749)1.93916345
70Gastrointestinal carcinoma (HP:0002672)1.93916345
71Difficulty climbing stairs (HP:0003551)1.93754887
72Aplasia involving forearm bones (HP:0009822)1.93720781
73Absent forearm bone (HP:0003953)1.93720781
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.93061632
75Abnormality of the ileum (HP:0001549)1.91714874
76Ankle contracture (HP:0006466)1.89964027
77Skull defect (HP:0001362)1.89642226
78Shallow orbits (HP:0000586)1.87802265
79Sloping forehead (HP:0000340)1.87585613
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.87300045
81Absent/shortened dynein arms (HP:0200106)1.87300045
82Progressive external ophthalmoplegia (HP:0000590)1.86896102
83Multiple enchondromatosis (HP:0005701)1.86474744
84Small intestinal stenosis (HP:0012848)1.85563011
85Duodenal stenosis (HP:0100867)1.85563011
8611 pairs of ribs (HP:0000878)1.85358267
87Coronal craniosynostosis (HP:0004440)1.83075345
88Deformed tarsal bones (HP:0008119)1.82622872
89Abnormality of the musculature of the pelvis (HP:0001469)1.82305435
90Abnormality of the hip-girdle musculature (HP:0001445)1.82305435
91Facial hemangioma (HP:0000329)1.81315176
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.79151825
93Amaurosis fugax (HP:0100576)1.77606932
94Abnormality of the preputium (HP:0100587)1.76931397
95Embryonal neoplasm (HP:0002898)1.76868161
96Ovarian neoplasm (HP:0100615)1.76666399
97Choanal stenosis (HP:0000452)1.76406961
98Microvesicular hepatic steatosis (HP:0001414)1.75590295
99Absent thumb (HP:0009777)1.74746554
100Abnormality of abdominal situs (HP:0011620)1.74722797
101Abdominal situs inversus (HP:0003363)1.74722797
102Protrusio acetabuli (HP:0003179)1.74566863
103Sandal gap (HP:0001852)1.74058083
104Trismus (HP:0000211)1.73871968
105Ankyloglossia (HP:0010296)1.73222066
106Intestinal polyp (HP:0005266)1.71997691
107Abnormality of the carotid arteries (HP:0005344)1.71616642
108Overlapping toe (HP:0001845)1.71242086
109Progressive muscle weakness (HP:0003323)1.70939610
110Abnormality of the duodenum (HP:0002246)1.69774419
111Termporal pattern (HP:0011008)1.69414083
112Insidious onset (HP:0003587)1.69414083
113Arnold-Chiari malformation (HP:0002308)1.69011176
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68532773
115Elfin facies (HP:0004428)1.68529002
116Renovascular hypertension (HP:0100817)1.68375326
117Skin tags (HP:0010609)1.66528507
118Adenoma sebaceum (HP:0009720)1.65681813
119Angiofibromas (HP:0010615)1.65681813
120Chronic bronchitis (HP:0004469)1.65543853
121Choanal atresia (HP:0000453)1.65534293
122Neoplasm of the rectum (HP:0100743)1.65380019
123Myelodysplasia (HP:0002863)1.64711055
124Short ribs (HP:0000773)1.64510685
125Increased density of long bones (HP:0006392)1.64438144
126Facial cleft (HP:0002006)1.63847321
127Broad thumb (HP:0011304)1.63788484
128Bowel diverticulosis (HP:0005222)1.63521134
129Obsessive-compulsive behavior (HP:0000722)1.63002307
130Spinal muscular atrophy (HP:0007269)1.62971048
131Neoplasm of the colon (HP:0100273)1.62966201
132Urethral obstruction (HP:0000796)1.61950772
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.59995963
134Trigonocephaly (HP:0000243)1.58861940
135Abnormality of chromosome segregation (HP:0002916)1.52827967
136Esophageal atresia (HP:0002032)1.52024718
137Breech presentation (HP:0001623)1.51982753
138Triphalangeal thumb (HP:0001199)1.51480743
139Abnormality of cochlea (HP:0000375)1.51426041
140Relative macrocephaly (HP:0004482)1.50978610
141Pterygium (HP:0001059)1.50875536
142Omphalocele (HP:0001539)1.50708518
143Microglossia (HP:0000171)1.50430227
144Exercise-induced muscle cramps (HP:0003710)1.49680546
145Glossoptosis (HP:0000162)1.48623924
146Uterine leiomyosarcoma (HP:0002891)1.47992568
147Leiomyosarcoma (HP:0100243)1.47992568
148Anal stenosis (HP:0002025)1.46614789
149Generalized hypotonia (HP:0001290)1.45186813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.93086544
2WEE13.42619609
3NEK23.10645432
4BUB12.92324308
5PDK42.88189828
6PDK32.88189828
7CDK122.80764606
8EEF2K2.76697595
9NEK12.68454804
10PASK2.45538251
11TSSK62.44933834
12TTK2.37730634
13PKN22.24707361
14PBK2.14636225
15SMG11.96641272
16TESK11.95284248
17TAF11.93768907
18MAP3K101.91425426
19PNCK1.78085753
20PDK21.70558491
21PLK11.67948514
22TRIB31.67306156
23ICK1.60048585
24EIF2AK11.59833930
25EPHA21.56530103
26CDK41.52302962
27BRSK21.52215731
28SRPK11.51247696
29PRKD31.50610081
30SCYL21.49090759
31ALK1.48708344
32LATS11.48706623
33RPS6KB21.48675168
34ATR1.47630744
35PLK31.47152005
36CAMK1G1.45654813
37CHEK11.44095010
38TTN1.41265972
39MKNK11.38357997
40CHEK21.35376715
41TESK21.33296824
42AURKB1.32717262
43LATS21.30919379
44PLK41.30776048
45MAP3K81.30419302
46CDK71.29216340
47PAK41.21771678
48CAMK1D1.21765276
49STK31.19698020
50MTOR1.12179855
51CDK61.10557145
52STK101.10530775
53TGFBR11.08022075
54DYRK31.05769265
55BRD41.04715376
56VRK21.04448907
57RPS6KA41.02184840
58MKNK20.99888524
59ATM0.97700303
60FLT30.96177813
61ACVR1B0.94986009
62ERBB40.94572398
63BRSK10.94218754
64CDK20.93311673
65PAK20.93153199
66AURKA0.85731747
67MAP3K90.84419978
68BRAF0.82578442
69EIF2AK20.82544890
70FGFR10.81413778
71STK240.73295795
72STK38L0.70798382
73PDGFRA0.69584242
74VRK10.68827148
75CDK80.67368765
76CDK10.67151745
77MST1R0.66801641
78NTRK10.66753949
79PAK10.64539515
80MELK0.62696078
81STK40.62573264
82CLK10.62449240
83CSNK1E0.61185764
84CDK190.60860397
85CCNB10.60798819
86TLK10.59811907
87PTK20.59288637
88CSNK1D0.54600259
89CDK150.54281126
90CDK11A0.54086162
91PTK60.53884828
92CSNK2A20.53770716
93CDK180.53170572
94LRRK20.52375984
95FGFR20.51633131
96PIK3CG0.50713031
97PIM10.49524172
98KSR10.49416512
99PRKDC0.49008494
100TYRO30.48443798
101MAP2K30.43670665
102CDK140.43660340
103EIF2AK30.42936213
104AKT20.42707403
105BCR0.42103971
106BMX0.41598172
107DMPK0.39548770
108TNIK0.38869453
109PLK20.38549078
110WNK10.34240355
111CSNK2A10.33779866
112STK380.31861668
113NME20.31412205
114MAPK140.30834689
115CDK90.30665227
116FGFR40.29730247
117PRKCI0.28909061
118RPS6KA10.28566316
119DDR20.27004965
120RIPK10.26736210
121GSK3B0.26418435
122RPS6KB10.23831998
123MET0.23594499
124MAPK10.23309610
125MAP3K50.22803740
126ZAK0.22501155
127AKT10.21688488
128PDGFRB0.21178777
129DYRK1B0.19753606
130NEK90.17717858
131MAPK100.16694369

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24519652
2RNA transport_Homo sapiens_hsa030133.72226996
3Mismatch repair_Homo sapiens_hsa034303.68514611
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63225649
5Spliceosome_Homo sapiens_hsa030403.08230157
6Cell cycle_Homo sapiens_hsa041103.00183048
7One carbon pool by folate_Homo sapiens_hsa006702.86062706
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73383231
9mRNA surveillance pathway_Homo sapiens_hsa030152.46314034
10Base excision repair_Homo sapiens_hsa034102.36143705
11Nucleotide excision repair_Homo sapiens_hsa034202.34205190
12Homologous recombination_Homo sapiens_hsa034402.15017506
13Fanconi anemia pathway_Homo sapiens_hsa034602.00664263
14RNA polymerase_Homo sapiens_hsa030201.76876951
15RNA degradation_Homo sapiens_hsa030181.64828295
16p53 signaling pathway_Homo sapiens_hsa041151.62965508
17Oocyte meiosis_Homo sapiens_hsa041141.62286542
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61487486
19Vitamin B6 metabolism_Homo sapiens_hsa007501.57144786
20Pyrimidine metabolism_Homo sapiens_hsa002401.55753748
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54275659
22Basal transcription factors_Homo sapiens_hsa030221.53873098
23Non-homologous end-joining_Homo sapiens_hsa034501.47618938
24Biosynthesis of amino acids_Homo sapiens_hsa012301.36703194
25Viral carcinogenesis_Homo sapiens_hsa052031.32876466
26Proteasome_Homo sapiens_hsa030501.30469711
27Selenocompound metabolism_Homo sapiens_hsa004501.28385029
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.23371921
29MicroRNAs in cancer_Homo sapiens_hsa052061.17180322
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15694096
31Antigen processing and presentation_Homo sapiens_hsa046121.14723419
32Ribosome_Homo sapiens_hsa030101.14207270
33Epstein-Barr virus infection_Homo sapiens_hsa051691.14100791
34Systemic lupus erythematosus_Homo sapiens_hsa053221.13477727
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10182451
36Small cell lung cancer_Homo sapiens_hsa052221.09769105
37Hippo signaling pathway_Homo sapiens_hsa043901.07343103
38mTOR signaling pathway_Homo sapiens_hsa041501.06241596
39HTLV-I infection_Homo sapiens_hsa051661.05945616
40Basal cell carcinoma_Homo sapiens_hsa052171.02333613
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.01483766
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96128749
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95713558
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92469355
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90439490
46Carbon metabolism_Homo sapiens_hsa012000.89513206
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88199938
48Pentose phosphate pathway_Homo sapiens_hsa000300.87947230
49Purine metabolism_Homo sapiens_hsa002300.87615897
50Adherens junction_Homo sapiens_hsa045200.86881167
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86457745
52Chronic myeloid leukemia_Homo sapiens_hsa052200.86112785
53Hedgehog signaling pathway_Homo sapiens_hsa043400.85136107
54Thyroid cancer_Homo sapiens_hsa052160.79320077
55Colorectal cancer_Homo sapiens_hsa052100.77731716
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76763098
57Propanoate metabolism_Homo sapiens_hsa006400.75149209
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74200031
59HIF-1 signaling pathway_Homo sapiens_hsa040660.73015723
60Steroid biosynthesis_Homo sapiens_hsa001000.71814072
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71141477
62Herpes simplex infection_Homo sapiens_hsa051680.69858086
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69044387
64TGF-beta signaling pathway_Homo sapiens_hsa043500.67690756
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67655158
66Bladder cancer_Homo sapiens_hsa052190.66454685
67Viral myocarditis_Homo sapiens_hsa054160.65639301
68Legionellosis_Homo sapiens_hsa051340.65073861
69Proteoglycans in cancer_Homo sapiens_hsa052050.64145535
70Tight junction_Homo sapiens_hsa045300.62045842
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61859448
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.61758247
73Notch signaling pathway_Homo sapiens_hsa043300.60807634
74Lysine degradation_Homo sapiens_hsa003100.57063314
75N-Glycan biosynthesis_Homo sapiens_hsa005100.56963864
76Endometrial cancer_Homo sapiens_hsa052130.56555139
77Glucagon signaling pathway_Homo sapiens_hsa049220.56373755
78Folate biosynthesis_Homo sapiens_hsa007900.55446393
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52616716
80Non-small cell lung cancer_Homo sapiens_hsa052230.52511821
81Arginine biosynthesis_Homo sapiens_hsa002200.52264834
82Prostate cancer_Homo sapiens_hsa052150.51854546
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50964678
84Fructose and mannose metabolism_Homo sapiens_hsa000510.47251181
85AMPK signaling pathway_Homo sapiens_hsa041520.47222229
86Pathways in cancer_Homo sapiens_hsa052000.46490665
87Wnt signaling pathway_Homo sapiens_hsa043100.46107319
88Melanogenesis_Homo sapiens_hsa049160.45792287
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45754657
90Arginine and proline metabolism_Homo sapiens_hsa003300.45379815
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44106562
92Focal adhesion_Homo sapiens_hsa045100.42805451
93Acute myeloid leukemia_Homo sapiens_hsa052210.42094194
94Alcoholism_Homo sapiens_hsa050340.41449819
95Apoptosis_Homo sapiens_hsa042100.40813233
96Hepatitis B_Homo sapiens_hsa051610.39931108
97Protein export_Homo sapiens_hsa030600.37410264
98Dorso-ventral axis formation_Homo sapiens_hsa043200.35234177
99Axon guidance_Homo sapiens_hsa043600.33450321
100Fatty acid metabolism_Homo sapiens_hsa012120.33094071
101VEGF signaling pathway_Homo sapiens_hsa043700.33001765
102Estrogen signaling pathway_Homo sapiens_hsa049150.32985555
103Renal cell carcinoma_Homo sapiens_hsa052110.32822793
104Glioma_Homo sapiens_hsa052140.32725069
105ErbB signaling pathway_Homo sapiens_hsa040120.32311446
106Melanoma_Homo sapiens_hsa052180.32124651
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31850098
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31720533
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31697265
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.31096953
111Pyruvate metabolism_Homo sapiens_hsa006200.29726493
112Pancreatic cancer_Homo sapiens_hsa052120.28890615
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28857763
114Insulin signaling pathway_Homo sapiens_hsa049100.28207796
115FoxO signaling pathway_Homo sapiens_hsa040680.27685064
116Dilated cardiomyopathy_Homo sapiens_hsa054140.27552840
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27451006
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26258530
119Gap junction_Homo sapiens_hsa045400.25115284
120Fatty acid biosynthesis_Homo sapiens_hsa000610.24308823
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.24177460
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23550885
123ECM-receptor interaction_Homo sapiens_hsa045120.23202313

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