IPO5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.94003037
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.73087805
3pyrimidine nucleobase catabolic process (GO:0006208)4.21486632
4epithelial cilium movement (GO:0003351)4.14532393
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.64679778
6regulation of translation, ncRNA-mediated (GO:0045974)3.64679778
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64679778
8response to pheromone (GO:0019236)3.49797071
9somite development (GO:0061053)3.46719636
10cilium movement (GO:0003341)3.41270288
11DNA double-strand break processing (GO:0000729)3.41094585
12axoneme assembly (GO:0035082)3.39332666
13limb bud formation (GO:0060174)3.39230306
14nucleobase catabolic process (GO:0046113)3.38894343
15fucose catabolic process (GO:0019317)3.38175790
16L-fucose metabolic process (GO:0042354)3.38175790
17L-fucose catabolic process (GO:0042355)3.38175790
18replication fork processing (GO:0031297)3.32471074
19indolalkylamine catabolic process (GO:0046218)3.31930502
20tryptophan catabolic process (GO:0006569)3.31930502
21indole-containing compound catabolic process (GO:0042436)3.31930502
22hindbrain development (GO:0030902)3.22762962
23kidney morphogenesis (GO:0060993)3.14254747
24neural tube formation (GO:0001841)3.13587276
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.11931122
26indolalkylamine metabolic process (GO:0006586)3.05708235
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.04174090
28nonmotile primary cilium assembly (GO:0035058)3.02608784
29presynaptic membrane assembly (GO:0097105)3.00698005
30nephron tubule morphogenesis (GO:0072078)2.96928433
31nephron epithelium morphogenesis (GO:0072088)2.96928433
32cornea development in camera-type eye (GO:0061303)2.96056986
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95274059
34neuron fate determination (GO:0048664)2.92400152
35cilium or flagellum-dependent cell motility (GO:0001539)2.92193139
36protein complex biogenesis (GO:0070271)2.88246731
37protein K11-linked deubiquitination (GO:0035871)2.86945124
38retinal cone cell development (GO:0046549)2.86837191
39mitochondrial respiratory chain complex I assembly (GO:0032981)2.85002114
40NADH dehydrogenase complex assembly (GO:0010257)2.85002114
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85002114
42cilium morphogenesis (GO:0060271)2.84710130
43protein-cofactor linkage (GO:0018065)2.84492251
44cilium organization (GO:0044782)2.83371459
45protein polyglutamylation (GO:0018095)2.82848245
46regulation of glucokinase activity (GO:0033131)2.81830135
47regulation of hexokinase activity (GO:1903299)2.81830135
48detection of light stimulus involved in visual perception (GO:0050908)2.79039542
49detection of light stimulus involved in sensory perception (GO:0050962)2.79039542
50S-adenosylmethionine metabolic process (GO:0046500)2.77305652
51tryptophan metabolic process (GO:0006568)2.77106941
52establishment of protein localization to mitochondrial membrane (GO:0090151)2.76625427
53cilium assembly (GO:0042384)2.75052751
54centriole replication (GO:0007099)2.74961660
55kynurenine metabolic process (GO:0070189)2.71601139
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70733463
57mitochondrial respiratory chain complex assembly (GO:0033108)2.70268757
58recombinational repair (GO:0000725)2.68333686
59photoreceptor cell maintenance (GO:0045494)2.68296680
60negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67586721
61regulation of action potential (GO:0098900)2.67245141
62double-strand break repair via homologous recombination (GO:0000724)2.66664482
63intraciliary transport (GO:0042073)2.66496678
64presynaptic membrane organization (GO:0097090)2.64518596
65mannosylation (GO:0097502)2.62679947
66cellular ketone body metabolic process (GO:0046950)2.61586475
67head development (GO:0060322)2.58913458
68regulation of telomere maintenance (GO:0032204)2.57848086
69spinal cord motor neuron differentiation (GO:0021522)2.57473727
70single strand break repair (GO:0000012)2.56032000
71retinal ganglion cell axon guidance (GO:0031290)2.55716914
72DNA deamination (GO:0045006)2.54556072
73regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53655723
74regulation of mitotic spindle checkpoint (GO:1903504)2.52926602
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52926602
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52265545
77positive regulation of oligodendrocyte differentiation (GO:0048714)2.50952003
78peptidyl-histidine modification (GO:0018202)2.50771886
79amine catabolic process (GO:0009310)2.50625182
80cellular biogenic amine catabolic process (GO:0042402)2.50625182
81renal tubule morphogenesis (GO:0061333)2.50392890
82respiratory chain complex IV assembly (GO:0008535)2.48647143
83olfactory bulb development (GO:0021772)2.47587772
84reciprocal DNA recombination (GO:0035825)2.47575822
85reciprocal meiotic recombination (GO:0007131)2.47575822
86regulation of cilium movement (GO:0003352)2.46981241
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46854452
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46733603
89somite rostral/caudal axis specification (GO:0032525)2.46729705
90microtubule depolymerization (GO:0007019)2.46023389
91piRNA metabolic process (GO:0034587)2.45732083
92platelet dense granule organization (GO:0060155)2.45589050
93behavioral response to ethanol (GO:0048149)2.45092187
94regulation of posttranscriptional gene silencing (GO:0060147)2.44912121
95regulation of gene silencing by miRNA (GO:0060964)2.44912121
96regulation of gene silencing by RNA (GO:0060966)2.44912121
97otic vesicle formation (GO:0030916)2.44531284
98axonemal dynein complex assembly (GO:0070286)2.44320925
99regulation of non-canonical Wnt signaling pathway (GO:2000050)2.43902419
100transmission of nerve impulse (GO:0019226)2.43710029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.94397339
2GBX2_23144817_ChIP-Seq_PC3_Human3.21039523
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87783194
4VDR_22108803_ChIP-Seq_LS180_Human2.71331034
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.60209346
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50639331
7FUS_26573619_Chip-Seq_HEK293_Human2.44200024
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43364358
9IGF1R_20145208_ChIP-Seq_DFB_Human2.43026148
10EZH2_22144423_ChIP-Seq_EOC_Human2.40774797
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32422903
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26469844
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26098571
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21627910
15EWS_26573619_Chip-Seq_HEK293_Human2.17165173
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16049475
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13237942
18TAF15_26573619_Chip-Seq_HEK293_Human2.12710653
19P300_19829295_ChIP-Seq_ESCs_Human2.12690209
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04232879
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.97830835
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89978137
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85102015
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81725332
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79897352
26IRF1_19129219_ChIP-ChIP_H3396_Human1.79258867
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70958760
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.69357531
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64345743
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63979983
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.61503241
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.61182387
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60092603
34ER_23166858_ChIP-Seq_MCF-7_Human1.59169698
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59056719
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59030586
37BCAT_22108803_ChIP-Seq_LS180_Human1.58022305
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.57787016
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57388862
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57388862
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52374964
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52198498
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52176281
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.51983513
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51791265
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48325741
47CBP_20019798_ChIP-Seq_JUKART_Human1.48325741
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47275591
49RNF2_27304074_Chip-Seq_NSC_Mouse1.46977356
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44363515
51STAT3_23295773_ChIP-Seq_U87_Human1.43277644
52MYC_18940864_ChIP-ChIP_HL60_Human1.43189300
53REST_21632747_ChIP-Seq_MESCs_Mouse1.42983197
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.42350781
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41275433
56AR_25329375_ChIP-Seq_VCAP_Human1.38833046
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37843986
58TP53_22573176_ChIP-Seq_HFKS_Human1.35764574
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35387896
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33063675
61TCF4_22108803_ChIP-Seq_LS180_Human1.30855409
62TCF4_23295773_ChIP-Seq_U87_Human1.30779788
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29485237
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27122403
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26884494
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26871605
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25106368
68RUNX2_22187159_ChIP-Seq_PCA_Human1.21733113
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20550927
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.20071254
71SOX2_19829295_ChIP-Seq_ESCs_Human1.20052267
72NANOG_19829295_ChIP-Seq_ESCs_Human1.20052267
73ELK1_19687146_ChIP-ChIP_HELA_Human1.17516868
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.16739029
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.14216517
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.12284253
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11989944
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.11848507
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.07827919
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06838215
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06453505
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.06453505
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04413991
84VDR_23849224_ChIP-Seq_CD4+_Human1.02532964
85P53_22387025_ChIP-Seq_ESCs_Mouse1.01505227
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.01466256
87AR_21572438_ChIP-Seq_LNCaP_Human1.01449488
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.00929244
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00697825
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99760193
91NCOR_22424771_ChIP-Seq_293T_Human0.99289492
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.95904574
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95445522
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93160164
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.92896599
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.92109721
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91845833
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91681954
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91659456
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.90907113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.52625391
2MP0008877_abnormal_DNA_methylation3.29167917
3MP0003787_abnormal_imprinting3.18270439
4MP0002102_abnormal_ear_morphology3.08704430
5MP0002638_abnormal_pupillary_reflex2.33899196
6MP0002938_white_spotting2.31403595
7MP0003880_abnormal_central_pattern2.30683708
8MP0006072_abnormal_retinal_apoptosis2.18568832
9MP0004133_heterotaxia2.08395733
10MP0005551_abnormal_eye_electrophysiolog2.05272857
11MP0003195_calcinosis2.03454096
12MP0002837_dystrophic_cardiac_calcinosis1.95906407
13MP0003121_genomic_imprinting1.93056851
14MP0003122_maternal_imprinting1.89435235
15MP0001968_abnormal_touch/_nociception1.85160849
16MP0003136_yellow_coat_color1.85121835
17MP0002653_abnormal_ependyma_morphology1.75251048
18MP0000569_abnormal_digit_pigmentation1.73301430
19MP0000631_abnormal_neuroendocrine_gland1.73209827
20MP0002736_abnormal_nociception_after1.70470902
21MP0005253_abnormal_eye_physiology1.69542214
22MP0000778_abnormal_nervous_system1.68844510
23MP0008789_abnormal_olfactory_epithelium1.67605663
24MP0002254_reproductive_system_inflammat1.60793381
25MP0002160_abnormal_reproductive_system1.56884698
26MP0004885_abnormal_endolymph1.56818670
27MP0001984_abnormal_olfaction1.55048207
28MP0001529_abnormal_vocalization1.54841537
29MP0006276_abnormal_autonomic_nervous1.52574350
30MP0003890_abnormal_embryonic-extraembry1.52132791
31MP0002876_abnormal_thyroid_physiology1.46429627
32MP0008872_abnormal_physiological_respon1.45901833
33MP0001486_abnormal_startle_reflex1.45487669
34MP0003283_abnormal_digestive_organ1.42870609
35MP0004742_abnormal_vestibular_system1.42080596
36MP0009745_abnormal_behavioral_response1.39667889
37MP0004142_abnormal_muscle_tone1.39386493
38MP0008058_abnormal_DNA_repair1.38751575
39MP0001293_anophthalmia1.38349180
40MP0000372_irregular_coat_pigmentation1.37048368
41MP0001919_abnormal_reproductive_system1.36099430
42MP0005394_taste/olfaction_phenotype1.35044704
43MP0005499_abnormal_olfactory_system1.35044704
44MP0001485_abnormal_pinna_reflex1.31824926
45MP0005645_abnormal_hypothalamus_physiol1.30488359
46MP0003119_abnormal_digestive_system1.29828760
47MP0002272_abnormal_nervous_system1.29480796
48MP0001986_abnormal_taste_sensitivity1.28845007
49MP0009046_muscle_twitch1.28681100
50MP0005389_reproductive_system_phenotype1.28519086
51MP0003718_maternal_effect1.28320012
52MP0002557_abnormal_social/conspecific_i1.26622246
53MP0002735_abnormal_chemical_nociception1.24170062
54MP0000427_abnormal_hair_cycle1.21701477
55MP0002751_abnormal_autonomic_nervous1.20424824
56MP0002928_abnormal_bile_duct1.20401141
57MP0008995_early_reproductive_senescence1.19016408
58MP0003937_abnormal_limbs/digits/tail_de1.17736706
59MP0002234_abnormal_pharynx_morphology1.17733279
60MP0005084_abnormal_gallbladder_morpholo1.16959586
61MP0005646_abnormal_pituitary_gland1.14185753
62MP0003011_delayed_dark_adaptation1.10589692
63MP0005195_abnormal_posterior_eye1.10102853
64MP0005386_behavior/neurological_phenoty1.09757484
65MP0004924_abnormal_behavior1.09757484
66MP0004147_increased_porphyrin_level1.08898120
67MP0001188_hyperpigmentation1.03597305
68MP0000049_abnormal_middle_ear1.02215898
69MP0002572_abnormal_emotion/affect_behav1.01527200
70MP0002752_abnormal_somatic_nervous0.99457736
71MP0003938_abnormal_ear_development0.98540728
72MP0008875_abnormal_xenobiotic_pharmacok0.97984813
73MP0001286_abnormal_eye_development0.97701914
74MP0000647_abnormal_sebaceous_gland0.96655862
75MP0002064_seizures0.95936262
76MP0005391_vision/eye_phenotype0.95753896
77MP0002163_abnormal_gland_morphology0.95726276
78MP0005377_hearing/vestibular/ear_phenot0.95550384
79MP0003878_abnormal_ear_physiology0.95550384
80MP0002233_abnormal_nose_morphology0.94957663
81MP0002067_abnormal_sensory_capabilities0.94864675
82MP0000955_abnormal_spinal_cord0.90366766
83MP0000383_abnormal_hair_follicle0.90266987
84MP0004043_abnormal_pH_regulation0.89934993
85MP0003635_abnormal_synaptic_transmissio0.88795963
86MP0003646_muscle_fatigue0.88538190
87MP0002277_abnormal_respiratory_mucosa0.88489196
88MP0000026_abnormal_inner_ear0.87670150
89MP0000566_synostosis0.87224379
90MP0003698_abnormal_male_reproductive0.86608633
91MP0005075_abnormal_melanosome_morpholog0.86271361
92MP0001929_abnormal_gametogenesis0.85756240
93MP0005423_abnormal_somatic_nervous0.85476710
94MP0002734_abnormal_mechanical_nocicepti0.84757740
95MP0002184_abnormal_innervation0.84721089
96MP0005379_endocrine/exocrine_gland_phen0.84391890
97MP0001970_abnormal_pain_threshold0.83535347
98MP0002063_abnormal_learning/memory/cond0.83181292
99MP0008057_abnormal_DNA_replication0.82697012
100MP0001324_abnormal_eye_pigmentation0.82476854

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.93833698
2Pancreatic fibrosis (HP:0100732)3.93609941
3Abnormality of midbrain morphology (HP:0002418)3.83280908
4Molar tooth sign on MRI (HP:0002419)3.83280908
5True hermaphroditism (HP:0010459)3.63649475
6Nephronophthisis (HP:0000090)3.38568693
7Type II lissencephaly (HP:0007260)3.08213466
8Congenital stationary night blindness (HP:0007642)3.00576706
9Abnormality of the renal medulla (HP:0100957)2.94267823
10Chronic hepatic failure (HP:0100626)2.93397602
11Abnormality of the labia minora (HP:0012880)2.90434966
12Hyperventilation (HP:0002883)2.89980104
13Medial flaring of the eyebrow (HP:0010747)2.80374827
14Abnormality of the renal cortex (HP:0011035)2.79350281
15Colon cancer (HP:0003003)2.62656344
16Lissencephaly (HP:0001339)2.50469638
17Cerebellar dysplasia (HP:0007033)2.49952911
18Optic nerve hypoplasia (HP:0000609)2.43873256
19Cystic liver disease (HP:0006706)2.43168284
20Pendular nystagmus (HP:0012043)2.42400853
21Abolished electroretinogram (ERG) (HP:0000550)2.34799842
22Abnormal respiratory epithelium morphology (HP:0012253)2.33851558
23Abnormal respiratory motile cilium morphology (HP:0005938)2.33851558
24Attenuation of retinal blood vessels (HP:0007843)2.33662689
25Intestinal atresia (HP:0011100)2.30658629
26Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30112092
27Gait imbalance (HP:0002141)2.23820825
28Sclerocornea (HP:0000647)2.21570344
29Anencephaly (HP:0002323)2.20204212
30Inability to walk (HP:0002540)2.20014979
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.19463069
32Absent/shortened dynein arms (HP:0200106)2.19463069
33Genital tract atresia (HP:0001827)2.19033506
34Congenital primary aphakia (HP:0007707)2.17666099
35Tubular atrophy (HP:0000092)2.17423173
36Septo-optic dysplasia (HP:0100842)2.16536498
37Abnormal biliary tract physiology (HP:0012439)2.14158421
38Bile duct proliferation (HP:0001408)2.14158421
39Hypoplasia of the pons (HP:0012110)2.11239032
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.10418224
41Vaginal atresia (HP:0000148)2.09758968
42Abnormal ciliary motility (HP:0012262)2.09162120
43Renal cortical cysts (HP:0000803)2.08228580
44Broad-based gait (HP:0002136)2.06954364
45Pachygyria (HP:0001302)2.06657961
46Abnormal rod and cone electroretinograms (HP:0008323)2.06427533
47Stomach cancer (HP:0012126)2.04675394
48Oligodactyly (hands) (HP:0001180)2.02893455
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.02719359
50Male pseudohermaphroditism (HP:0000037)2.00329663
51Aplasia/Hypoplasia of the uvula (HP:0010293)1.99209137
52Aplasia/Hypoplasia of the spleen (HP:0010451)1.98870502
53Abnormality of the pons (HP:0007361)1.98261866
54Anophthalmia (HP:0000528)1.98066516
55Nephrogenic diabetes insipidus (HP:0009806)1.98039762
56Postaxial foot polydactyly (HP:0001830)1.97688387
57Polydipsia (HP:0001959)1.95006857
58Abnormal drinking behavior (HP:0030082)1.95006857
59Postaxial hand polydactyly (HP:0001162)1.94041193
60Tubulointerstitial nephritis (HP:0001970)1.93740368
61Supernumerary spleens (HP:0009799)1.92449866
62Preaxial hand polydactyly (HP:0001177)1.90535027
63Occipital encephalocele (HP:0002085)1.89821657
64Meckel diverticulum (HP:0002245)1.89312305
65Drooling (HP:0002307)1.89153789
66Narrow forehead (HP:0000341)1.88979484
67Abnormality of the ileum (HP:0001549)1.88298757
68Neoplasm of the adrenal cortex (HP:0100641)1.88025322
69Asplenia (HP:0001746)1.87180960
70Protruding tongue (HP:0010808)1.87009185
71Methylmalonic acidemia (HP:0002912)1.86925829
72Acute necrotizing encephalopathy (HP:0006965)1.86420586
73Congenital hepatic fibrosis (HP:0002612)1.86245986
74Dandy-Walker malformation (HP:0001305)1.84179448
75Bony spicule pigmentary retinopathy (HP:0007737)1.83496534
76Patellar aplasia (HP:0006443)1.81350874
77Gaze-evoked nystagmus (HP:0000640)1.81243240
78Progressive inability to walk (HP:0002505)1.80943598
79Ectopic kidney (HP:0000086)1.80505643
80Congenital, generalized hypertrichosis (HP:0004540)1.78603384
81Hypothermia (HP:0002045)1.77844866
82Acute encephalopathy (HP:0006846)1.77324687
83Hyperglycinuria (HP:0003108)1.74022443
84Bilateral microphthalmos (HP:0007633)1.73048577
85Febrile seizures (HP:0002373)1.72778744
86Abnormal respiratory motile cilium physiology (HP:0012261)1.72731639
87Short tibia (HP:0005736)1.72470332
88Absent speech (HP:0001344)1.72432128
89Tented upper lip vermilion (HP:0010804)1.72140355
90Retinal dysplasia (HP:0007973)1.72061655
91Hyperglycinemia (HP:0002154)1.70910113
92Increased corneal curvature (HP:0100692)1.70369741
93Keratoconus (HP:0000563)1.70369741
94Methylmalonic aciduria (HP:0012120)1.69975158
95Concave nail (HP:0001598)1.69025172
96Abnormality of chromosome stability (HP:0003220)1.67679299
97Aplasia/Hypoplasia of the patella (HP:0006498)1.67299464
98Increased CSF lactate (HP:0002490)1.66483124
99Excessive salivation (HP:0003781)1.66310523
100Progressive macrocephaly (HP:0004481)1.65604905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.18484823
2WNK32.87961186
3MAP4K22.76351922
4CASK2.62370468
5GRK12.60655366
6ZAK2.52506047
7TNIK2.43846906
8NUAK12.35122960
9PNCK2.25757970
10TRIM282.17072978
11ADRBK22.10703891
12BMPR1B2.07667411
13MAPK132.03070182
14PINK12.03005967
15MAP3K41.84116937
16DYRK21.72982720
17MKNK21.69394847
18WEE11.61617140
19ACVR1B1.60647345
20WNK41.57427961
21AKT31.52630254
22PLK41.49760537
23INSRR1.47573622
24VRK11.45992049
25BRSK21.44527029
26MARK11.38325625
27FGFR21.35872920
28STK38L1.30769596
29PAK31.25927416
30PASK1.24225597
31NLK1.21246258
32MAP2K71.19700306
33EPHA41.16160045
34DAPK21.15699519
35PLK21.15369059
36CSNK1G11.15008611
37CSNK1G21.12906215
38TLK11.12795822
39MKNK11.12303261
40TSSK61.08780326
41DYRK31.07499822
42PLK31.06023055
43BCR1.04956655
44CSNK1G31.00563934
45OXSR11.00439736
46PRKCG1.00403650
47PRKCE0.95269157
48CDC70.94300076
49VRK20.91165093
50STK390.88953217
51CSNK1A1L0.86932097
52PIK3CA0.86770362
53CAMKK20.85389735
54TAOK30.80605409
55ERBB30.78852486
56MAPK150.78041478
57STK30.77442134
58SGK20.72996198
59TGFBR10.66152444
60ADRBK10.63428402
61SGK2230.63195366
62SGK4940.63195366
63BCKDK0.62037038
64PLK10.60379133
65CAMK1G0.59229332
66NTRK30.57517767
67TAF10.57116480
68NTRK20.56176609
69CDK90.56014317
70SRPK10.54702382
71DYRK1A0.53580315
72PKN10.53086708
73ATR0.53030578
74MAP2K40.52103856
75EPHB20.46651270
76ATM0.46165289
77CSNK1A10.44651450
78CDK30.44537513
79CDK190.42977370
80CSNK1D0.42957230
81CHEK20.41346875
82MUSK0.40487464
83MAP2K20.40486776
84PRKACA0.40027570
85PRKCQ0.39290935
86TYRO30.38850876
87TTK0.38233958
88STK110.37402350
89NEK20.37329349
90MINK10.37163288
91GRK70.36755100
92PTK2B0.36210793
93CAMK10.35883960
94CAMK1D0.35114430
95RPS6KA50.34347571
96CAMK40.33193627
97MST40.33074653
98CSNK1E0.32896213
99PRKCZ0.32681167
100TIE10.32170508

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85892645
2Phototransduction_Homo sapiens_hsa047442.72561955
3Butanoate metabolism_Homo sapiens_hsa006502.55482956
4Protein export_Homo sapiens_hsa030602.35601426
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.31862291
6Fanconi anemia pathway_Homo sapiens_hsa034602.26582361
7Homologous recombination_Homo sapiens_hsa034402.25725393
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24582465
9Oxidative phosphorylation_Homo sapiens_hsa001902.18255490
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05027603
11Nicotine addiction_Homo sapiens_hsa050331.92103639
12RNA polymerase_Homo sapiens_hsa030201.90582561
13Basal transcription factors_Homo sapiens_hsa030221.87683138
14Linoleic acid metabolism_Homo sapiens_hsa005911.84065232
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80481915
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78977430
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78130738
18Parkinsons disease_Homo sapiens_hsa050121.76958134
19Selenocompound metabolism_Homo sapiens_hsa004501.74314699
20RNA degradation_Homo sapiens_hsa030181.71113391
21Nitrogen metabolism_Homo sapiens_hsa009101.69739624
22Propanoate metabolism_Homo sapiens_hsa006401.66248661
23Non-homologous end-joining_Homo sapiens_hsa034501.64855090
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64626178
25Tryptophan metabolism_Homo sapiens_hsa003801.60844080
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59246497
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56389427
28Caffeine metabolism_Homo sapiens_hsa002321.44007150
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36115017
30Peroxisome_Homo sapiens_hsa041461.34432481
31Ether lipid metabolism_Homo sapiens_hsa005651.31867888
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31225333
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30713286
34Huntingtons disease_Homo sapiens_hsa050161.30091616
35Chemical carcinogenesis_Homo sapiens_hsa052041.29337067
36Basal cell carcinoma_Homo sapiens_hsa052171.28358679
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27991842
38Steroid biosynthesis_Homo sapiens_hsa001001.22707521
39Retinol metabolism_Homo sapiens_hsa008301.16300744
40Taste transduction_Homo sapiens_hsa047421.15195766
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.14750717
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.06273125
43One carbon pool by folate_Homo sapiens_hsa006701.05265854
44beta-Alanine metabolism_Homo sapiens_hsa004101.04716404
45Alzheimers disease_Homo sapiens_hsa050101.02809130
46Hedgehog signaling pathway_Homo sapiens_hsa043400.99404606
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99226582
48Olfactory transduction_Homo sapiens_hsa047400.98326396
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97488124
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96197060
51Morphine addiction_Homo sapiens_hsa050320.94025126
52Cardiac muscle contraction_Homo sapiens_hsa042600.93872871
53Insulin secretion_Homo sapiens_hsa049110.91767404
54Mismatch repair_Homo sapiens_hsa034300.91766774
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87951322
56ABC transporters_Homo sapiens_hsa020100.83585210
57Regulation of autophagy_Homo sapiens_hsa041400.82142102
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81112729
59Fat digestion and absorption_Homo sapiens_hsa049750.79493379
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78225730
61Serotonergic synapse_Homo sapiens_hsa047260.74050438
62RNA transport_Homo sapiens_hsa030130.73989396
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.73469716
64Circadian entrainment_Homo sapiens_hsa047130.70933685
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70347985
66Glutamatergic synapse_Homo sapiens_hsa047240.69976815
67Vitamin digestion and absorption_Homo sapiens_hsa049770.69080082
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68394823
69Fatty acid degradation_Homo sapiens_hsa000710.67436106
70Hippo signaling pathway_Homo sapiens_hsa043900.66671283
71GABAergic synapse_Homo sapiens_hsa047270.66662090
72Nucleotide excision repair_Homo sapiens_hsa034200.66393771
73Purine metabolism_Homo sapiens_hsa002300.66071108
74Dopaminergic synapse_Homo sapiens_hsa047280.66023548
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65043826
76Proteasome_Homo sapiens_hsa030500.64409824
77Lysine degradation_Homo sapiens_hsa003100.62517819
78Arachidonic acid metabolism_Homo sapiens_hsa005900.62431324
79Metabolic pathways_Homo sapiens_hsa011000.62240438
80Histidine metabolism_Homo sapiens_hsa003400.57502672
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54095777
82Amphetamine addiction_Homo sapiens_hsa050310.51140895
83Ribosome_Homo sapiens_hsa030100.50279040
84Glycerolipid metabolism_Homo sapiens_hsa005610.49824975
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49549674
86Spliceosome_Homo sapiens_hsa030400.49047244
87Pyrimidine metabolism_Homo sapiens_hsa002400.48955825
88Circadian rhythm_Homo sapiens_hsa047100.48685409
89Base excision repair_Homo sapiens_hsa034100.48297651
90Cocaine addiction_Homo sapiens_hsa050300.45965852
91Wnt signaling pathway_Homo sapiens_hsa043100.45763559
92Ovarian steroidogenesis_Homo sapiens_hsa049130.41888725
93Fatty acid metabolism_Homo sapiens_hsa012120.40447531
94Vitamin B6 metabolism_Homo sapiens_hsa007500.38641460
95Axon guidance_Homo sapiens_hsa043600.38289100
96Collecting duct acid secretion_Homo sapiens_hsa049660.38058171
97TGF-beta signaling pathway_Homo sapiens_hsa043500.37848804
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36511448
99Pyruvate metabolism_Homo sapiens_hsa006200.36394662
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.34788518

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