ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kynurenine metabolic process (GO:0070189)	9.78470896
2	sulfate transport (GO:0008272)	9.29276637
3	indolalkylamine catabolic process (GO:0046218)	9.05056169
4	tryptophan catabolic process (GO:0006569)	9.05056169
5	indole-containing compound catabolic process (GO:0042436)	9.05056169
6	activated T cell proliferation (GO:0050798)	8.32269609
7	tryptophan metabolic process (GO:0006568)	7.11866567
8	arginine metabolic process (GO:0006525)	6.69621990
9	urea cycle (GO:0000050)	6.44201100
10	amine catabolic process (GO:0009310)	6.29662707
11	cellular biogenic amine catabolic process (GO:0042402)	6.29662707
12	platelet dense granule organization (GO:0060155)	6.09352973
13	urea metabolic process (GO:0019627)	5.82758813
14	female mating behavior (GO:0060180)	5.79464486
15	fatty acid transmembrane transport (GO:1902001)	5.58649666
16	neuron fate determination (GO:0048664)	5.54671288
17	inositol phosphate-mediated signaling (GO:0048016)	5.51573657
18	aromatic amino acid family catabolic process (GO:0009074)	5.27715867
19	snRNA transcription (GO:0009301)	5.25975032
20	nitrogen cycle metabolic process (GO:0071941)	5.14879200
21	indolalkylamine metabolic process (GO:0006586)	5.01923610
22	glutamine family amino acid biosynthetic process (GO:0009084)	4.97916339
23	cellular response to interferon-beta (GO:0035458)	4.96464519
24	cellular ketone body metabolic process (GO:0046950)	4.70727125
25	fucose metabolic process (GO:0006004)	4.53627085
26	sulfur compound transport (GO:0072348)	4.45931070
27	positive regulation of T cell apoptotic process (GO:0070234)	4.42704401
28	fucosylation (GO:0036065)	4.22177672
29	ketone body metabolic process (GO:1902224)	4.17064921
30	regulation of telomerase activity (GO:0051972)	4.01702176
31	DNA strand renaturation (GO:0000733)	4.01364368
32	benzene-containing compound metabolic process (GO:0042537)	3.98026319
33	polarized epithelial cell differentiation (GO:0030859)	3.90341836
34	regulation of histone deacetylation (GO:0031063)	3.88006353
35	positive regulation of protein homodimerization activity (GO:0090073)	3.77109935
36	brain morphogenesis (GO:0048854)	3.76308749
37	nephron epithelium morphogenesis (GO:0072088)	3.72606505
38	nephron tubule morphogenesis (GO:0072078)	3.72606505
39	DNA excision (GO:0044349)	3.67614481
40	nucleotide-excision repair, DNA damage removal (GO:0000718)	3.67614481
41	cerebral cortex radially oriented cell migration (GO:0021799)	3.65254100
42	lipopolysaccharide biosynthetic process (GO:0009103)	3.62249215
43	regulation of phospholipase A2 activity (GO:0032429)	3.58175234
44	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.57313513
45	metanephric tubule development (GO:0072170)	3.54691819
46	metanephric nephron tubule development (GO:0072234)	3.54691819
47	multicellular organismal reproductive behavior (GO:0033057)	3.53899320
48	replication fork processing (GO:0031297)	3.53816650
49	carnitine shuttle (GO:0006853)	3.49405374
50	indole-containing compound metabolic process (GO:0042430)	3.47707291
51	regulation of somitogenesis (GO:0014807)	3.45680821
52	outer ear morphogenesis (GO:0042473)	3.42402054
53	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.42276596
54	aromatic amino acid family metabolic process (GO:0009072)	3.38898515
55	pattern specification involved in kidney development (GO:0061004)	3.33972905
56	cell differentiation involved in metanephros development (GO:0072202)	3.33020804
57	positive regulation of histone deacetylation (GO:0031065)	3.27850882
58	auditory receptor cell differentiation (GO:0042491)	3.26407612
59	positive regulation of protein homooligomerization (GO:0032464)	3.24453691
60	cell wall macromolecule catabolic process (GO:0016998)	3.23699317
61	regulation of RIG-I signaling pathway (GO:0039535)	3.20626191
62	NLS-bearing protein import into nucleus (GO:0006607)	3.19084815
63	N-terminal protein amino acid acetylation (GO:0006474)	3.18524220
64	melanosome organization (GO:0032438)	3.13349540
65	regulation of fibroblast apoptotic process (GO:2000269)	3.12998168
66	positive regulation of protein oligomerization (GO:0032461)	3.12002536
67	metanephric nephron epithelium development (GO:0072243)	3.10865444
68	positive regulation of DNA biosynthetic process (GO:2000573)	3.09940439
69	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.08053649
70	GTP biosynthetic process (GO:0006183)	3.02772327
71	chaperone-mediated protein transport (GO:0072321)	3.02393271
72	lipopolysaccharide metabolic process (GO:0008653)	3.02143452
73	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	3.01506692
74	neuron remodeling (GO:0016322)	3.01296346
75	synaptic transmission, cholinergic (GO:0007271)	3.00244845
76	acrosome reaction (GO:0007340)	2.99921640
77	regulation of protein deacetylation (GO:0090311)	2.97748618
78	cellular response to exogenous dsRNA (GO:0071360)	2.94086934
79	response to interferon-beta (GO:0035456)	2.93745493
80	embryonic body morphogenesis (GO:0010172)	2.93206619
81	pigment granule organization (GO:0048753)	2.92047471
82	negative regulation of fibroblast apoptotic process (GO:2000270)	2.89258019
83	positive regulation of interferon-alpha production (GO:0032727)	2.87009844
84	anterograde synaptic vesicle transport (GO:0048490)	2.86854517
85	ribosomal small subunit assembly (GO:0000028)	2.86704485
86	protein autoprocessing (GO:0016540)	2.85219935
87	viral transcription (GO:0019083)	2.85024262
88	metanephric epithelium development (GO:0072207)	2.84292230
89	translational termination (GO:0006415)	2.79174801
90	dendritic spine morphogenesis (GO:0060997)	2.77319395
91	inner mitochondrial membrane organization (GO:0007007)	2.76561213
92	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.74835791
93	carnitine transmembrane transport (GO:1902603)	2.74319728
94	arachidonic acid secretion (GO:0050482)	2.73018530
95	icosanoid secretion (GO:0032309)	2.73018530
96	axonemal dynein complex assembly (GO:0070286)	2.72990123
97	body morphogenesis (GO:0010171)	2.72910858
98	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.72062624
99	cell wall macromolecule metabolic process (GO:0044036)	2.68726282
100	sulfate transmembrane transport (GO:1902358)	11.0837531

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.05902936
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.67967387
3	IRF1_19129219_ChIP-ChIP_H3396_Human	2.63056139
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.50581790
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.15883599
6	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.11720885
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.07439819
8	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.96918386
9	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.91473752
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91004982
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87455939
12	TP53_16413492_ChIP-PET_HCT116_Human	1.85995956
13	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.85880016
14	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.85010017
15	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.78755746
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.72142502
17	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.70685423
18	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.69944335
19	LXR_22292898_ChIP-Seq_THP-1_Human	1.68420657
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66126847
21	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.65019909
22	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.63002596
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.62509863
24	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.60721442
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.60415131
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56060086
27	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.56003439
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50784041
29	SOX2_21211035_ChIP-Seq_LN229_Human	1.49490218
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.44804104
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.43490227
32	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.42852063
33	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.42653827
34	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.41647786
35	SA1_27219007_Chip-Seq_Bcells_Human	1.38455850
36	KLF5_25053715_ChIP-Seq_YYC3_Human	1.36795653
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36404084
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34133382
39	P68_20966046_ChIP-Seq_HELA_Human	1.34029837
40	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.32773892
41	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.31620818
42	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.31258443
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.31258443
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29202883
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28960328
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26508621
47	OCT4_19829295_ChIP-Seq_ESCs_Human	1.26255362
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26183669
49	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.22560430
50	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.22485787
51	ERA_21632823_ChIP-Seq_H3396_Human	1.21462083
52	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18659562
53	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.18626204
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17092584
55	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.16844483
56	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.16835256
57	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.16753188
58	CTCF_27219007_Chip-Seq_Bcells_Human	1.16349383
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15936050
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15936050
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14676790
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13253884
63	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.10738105
64	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.10393159
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.08185857
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08183256
67	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.07842609
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07590295
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07576463
70	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06482807
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.05626944
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.05089260
73	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.04950854
74	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.03959107
75	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.03360128
76	E2F1_20622854_ChIP-Seq_HELA_Human	1.03336348
77	KLF4_19829295_ChIP-Seq_ESCs_Human	1.02558951
78	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01957826
79	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.01935499
80	RXR_22108803_ChIP-Seq_LS180_Human	1.01508492
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00371112
82	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99225195
83	IGF1R_20145208_ChIP-Seq_DFB_Human	0.98387570
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97606617
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.97419376
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95835840
87	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95797364
88	BCOR_27268052_Chip-Seq_Bcells_Human	0.95076104
89	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93694125
90	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.91157970
91	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.90581591
92	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.89935474
93	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.88933184
94	TP53_22127205_ChIP-Seq_IMR90_Human	0.88912773
95	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.88229373
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87834723
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.86718932
98	VDR_22108803_ChIP-Seq_LS180_Human	0.85911758
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.85657275
100	TP63_22573176_ChIP-Seq_HFKS_Human	0.83232950

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	9.68285433
2	MP0006292_abnormal_olfactory_placode	3.91927047
3	MP0002653_abnormal_ependyma_morphology	2.83504203
4	MP0008875_abnormal_xenobiotic_pharmacok	2.82370228
5	MP0005174_abnormal_tail_pigmentation	2.59024481
6	MP0002254_reproductive_system_inflammat	2.53115358
7	MP0001188_hyperpigmentation	2.31734409
8	MP0005409_darkened_coat_color	2.25543913
9	MP0004142_abnormal_muscle_tone	2.19431519
10	MP0004147_increased_porphyrin_level	2.18228836
11	MP0002837_dystrophic_cardiac_calcinosis	2.17136709
12	MP0002876_abnormal_thyroid_physiology	2.17011719
13	MP0004233_abnormal_muscle_weight	2.11635415
14	MP0001790_abnormal_immune_system	2.01518891
15	MP0005387_immune_system_phenotype	2.01518891
16	MP0005410_abnormal_fertilization	1.95233176
17	MP0002735_abnormal_chemical_nociception	1.91886150
18	MP0008789_abnormal_olfactory_epithelium	1.91782587
19	MP0006276_abnormal_autonomic_nervous	1.90544725
20	MP0004885_abnormal_endolymph	1.83229191
21	MP0005551_abnormal_eye_electrophysiolog	1.67531705
22	MP0000049_abnormal_middle_ear	1.64321525
23	MP0002736_abnormal_nociception_after	1.61372654
24	MP0005394_taste/olfaction_phenotype	1.57721410
25	MP0005499_abnormal_olfactory_system	1.57721410
26	MP0009046_muscle_twitch	1.55536080
27	MP0002163_abnormal_gland_morphology	1.53254743
28	MP0002168_other_aberrant_phenotype	1.51274782
29	MP0001968_abnormal_touch/_nociception	1.50670539
30	MP0000778_abnormal_nervous_system	1.49827920
31	MP0003646_muscle_fatigue	1.47822520
32	MP0004859_abnormal_synaptic_plasticity	1.46655939
33	MP0003011_delayed_dark_adaptation	1.45583719
34	MP0002638_abnormal_pupillary_reflex	1.42416008
35	MP0000015_abnormal_ear_pigmentation	1.42017757
36	MP0003959_abnormal_lean_body	1.41984247
37	MP0004130_abnormal_muscle_cell	1.40744858
38	MP0001502_abnormal_circadian_rhythm	1.40684012
39	MP0002095_abnormal_skin_pigmentation	1.39972516
40	MP0005167_abnormal_blood-brain_barrier	1.39897746
41	MP0002733_abnormal_thermal_nociception	1.28743427
42	MP0000383_abnormal_hair_follicle	1.27317476
43	MP0003045_fibrosis	1.23942655
44	MP0008058_abnormal_DNA_repair	1.22745498
45	MP0005448_abnormal_energy_balance	1.22081481
46	MP0003656_abnormal_erythrocyte_physiolo	1.21014277
47	MP0001348_abnormal_lacrimal_gland	1.20052400
48	MP0003638_abnormal_response/metabolism_	1.19850179
49	MP0005647_abnormal_sex_gland	1.16438979
50	MP0005085_abnormal_gallbladder_physiolo	1.16003480
51	MP0001905_abnormal_dopamine_level	1.14769395
52	MP0002090_abnormal_vision	1.07477212
53	MP0005195_abnormal_posterior_eye	1.07230168
54	MP0005379_endocrine/exocrine_gland_phen	1.04119353
55	MP0002234_abnormal_pharynx_morphology	0.97735489
56	MP0001485_abnormal_pinna_reflex	0.95484803
57	MP0005084_abnormal_gallbladder_morpholo	0.95158641
58	MP0002272_abnormal_nervous_system	0.94881193
59	MP0002233_abnormal_nose_morphology	0.94582093
60	MP0002557_abnormal_social/conspecific_i	0.93994342
61	MP0004924_abnormal_behavior	0.92863189
62	MP0005386_behavior/neurological_phenoty	0.92863189
63	MP0001963_abnormal_hearing_physiology	0.92034386
64	MP0004782_abnormal_surfactant_physiolog	0.91731793
65	MP0001853_heart_inflammation	0.90722887
66	MP0001293_anophthalmia	0.90237083
67	MP0005377_hearing/vestibular/ear_phenot	0.88945938
68	MP0003878_abnormal_ear_physiology	0.88945938
69	MP0004043_abnormal_pH_regulation	0.83466794
70	MP0001970_abnormal_pain_threshold	0.82907505
71	MP0001486_abnormal_startle_reflex	0.81616051
72	MP0009745_abnormal_behavioral_response	0.80985244
73	MP0005645_abnormal_hypothalamus_physiol	0.80777565
74	MP0002210_abnormal_sex_determination	0.79230282
75	MP0005395_other_phenotype	0.78341871
76	MP0009764_decreased_sensitivity_to	0.77918907
77	MP0000230_abnormal_systemic_arterial	0.77882435
78	MP0005595_abnormal_vascular_smooth	0.77490767
79	MP0005408_hypopigmentation	0.76946847
80	MP0001191_abnormal_skin_condition	0.74964745
81	MP0008770_decreased_survivor_rate	0.74338563
82	MP0002177_abnormal_outer_ear	0.74002470
83	MP0009697_abnormal_copulation	0.73977371
84	MP0001145_abnormal_male_reproductive	0.72897000
85	MP0003635_abnormal_synaptic_transmissio	0.72827118
86	MP0001929_abnormal_gametogenesis	0.72666583
87	MP0002752_abnormal_somatic_nervous	0.71987441
88	MP0005310_abnormal_salivary_gland	0.71019770
89	MP0003953_abnormal_hormone_level	0.70952164
90	MP0004264_abnormal_extraembryonic_tissu	0.70925754
91	MP0002229_neurodegeneration	0.69068253
92	MP0003880_abnormal_central_pattern	0.68321899
93	MP0000653_abnormal_sex_gland	0.67956930
94	MP0002160_abnormal_reproductive_system	0.65400748
95	MP0003938_abnormal_ear_development	0.65219599
96	MP0001661_extended_life_span	0.65079393
97	MP0001849_ear_inflammation	0.63553026
98	MP0003698_abnormal_male_reproductive	0.62299247
99	MP0002118_abnormal_lipid_homeostasis	0.62125373
100	MP0000631_abnormal_neuroendocrine_gland	0.61425499

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Entropion (HP:0000621)	9.70250590
2	Poikiloderma (HP:0001029)	8.21850077
3	Abnormality of DNA repair (HP:0003254)	7.90560999
4	Confusion (HP:0001289)	5.44594368
5	Type 2 muscle fiber atrophy (HP:0003554)	4.59069927
6	Ectropion (HP:0000656)	4.41788362
7	Papilledema (HP:0001085)	4.29379357
8	Muscle fiber atrophy (HP:0100295)	4.08587488
9	Type II lissencephaly (HP:0007260)	4.04994364
10	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.01017267
11	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.91839366
12	Rectal prolapse (HP:0002035)	3.75902376
13	Cerebellar dysplasia (HP:0007033)	3.58506381
14	Abnormality of the axillary hair (HP:0100134)	3.47784644
15	Abnormality of secondary sexual hair (HP:0009888)	3.47784644
16	Facial hemangioma (HP:0000329)	3.37092689
17	Anomalous pulmonary venous return (HP:0010772)	3.33613770
18	Increased cerebral lipofuscin (HP:0011813)	3.33108387
19	Respiratory distress (HP:0002098)	3.28813617
20	Selective tooth agenesis (HP:0001592)	3.12902951
21	Squamous cell carcinoma (HP:0002860)	3.10271580
22	Pancreatic fibrosis (HP:0100732)	3.10057636
23	Hyperammonemia (HP:0001987)	3.06467124
24	True hermaphroditism (HP:0010459)	3.06110226
25	Cortical visual impairment (HP:0100704)	3.01490264
26	Breast hypoplasia (HP:0003187)	2.99459002
27	Severe muscular hypotonia (HP:0006829)	2.90502198
28	Keratitis (HP:0000491)	2.89732904
29	Abnormality of the pulmonary veins (HP:0011718)	2.89303947
30	Molar tooth sign on MRI (HP:0002419)	2.79316531
31	Abnormality of midbrain morphology (HP:0002418)	2.79316531
32	Supernumerary nipples (HP:0002558)	2.76092738
33	Colon cancer (HP:0003003)	2.73286640
34	Hypoplasia of the pons (HP:0012110)	2.72097878
35	Pancreatic cysts (HP:0001737)	2.68751711
36	Abnormal biliary tract physiology (HP:0012439)	2.66433665
37	Bile duct proliferation (HP:0001408)	2.66433665
38	Visual hallucinations (HP:0002367)	2.62724586
39	Optic nerve coloboma (HP:0000588)	2.61738237
40	Cutaneous photosensitivity (HP:0000992)	2.52866348
41	Hydroureter (HP:0000072)	2.51766336
42	Poor eye contact (HP:0000817)	2.51274696
43	Sex reversal (HP:0012245)	2.50397465
44	Abnormal sex determination (HP:0012244)	2.50397465
45	Meningocele (HP:0002435)	2.48269935
46	Renal dysplasia (HP:0000110)	2.47883687
47	Abnormality of the neuromuscular junction (HP:0003398)	2.43649391
48	Fatigable weakness (HP:0003473)	2.43649391
49	Cystic liver disease (HP:0006706)	2.40426927
50	Sclerocornea (HP:0000647)	2.37691391
51	Poor suck (HP:0002033)	2.34928422
52	Abnormality of the pons (HP:0007361)	2.33259485
53	Abnormality of macular pigmentation (HP:0008002)	2.28381400
54	Non-midline cleft lip (HP:0100335)	2.25598543
55	Rough bone trabeculation (HP:0100670)	2.24741966
56	Asplenia (HP:0001746)	2.23753502
57	Nonprogressive disorder (HP:0003680)	2.21627994
58	Alopecia of scalp (HP:0002293)	2.20187349
59	Nephronophthisis (HP:0000090)	2.17339227
60	Duplicated collecting system (HP:0000081)	2.17076215
61	Conical tooth (HP:0000698)	2.15400592
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13893102
63	Stridor (HP:0010307)	2.13871823
64	Thick nail (HP:0001805)	2.11975711
65	Impaired social interactions (HP:0000735)	2.10802705
66	Abnormal social behavior (HP:0012433)	2.10802705
67	Amyloidosis (HP:0011034)	2.09840444
68	Abnormal rod and cone electroretinograms (HP:0008323)	2.05329977
69	Congenital stationary night blindness (HP:0007642)	2.04029963
70	Abnormal ciliary motility (HP:0012262)	2.03619872
71	Upper motor neuron abnormality (HP:0002127)	2.03522365
72	Attenuation of retinal blood vessels (HP:0007843)	2.03451665
73	Cupped ear (HP:0000378)	2.03053040
74	Lissencephaly (HP:0001339)	2.01902318
75	Abnormality of the renal collecting system (HP:0004742)	1.97934125
76	Megalencephaly (HP:0001355)	1.97923158
77	Pustule (HP:0200039)	1.92299483
78	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.91541881
79	Broad hallux (HP:0010055)	1.90710729
80	Furrowed tongue (HP:0000221)	1.89471285
81	Distal lower limb muscle weakness (HP:0009053)	1.89040338
82	Decreased muscle mass (HP:0003199)	1.88256129
83	Weak cry (HP:0001612)	1.88095485
84	Scanning speech (HP:0002168)	1.87009643
85	Premature graying of hair (HP:0002216)	1.84444155
86	Hypogonadotrophic hypogonadism (HP:0000044)	1.84219134
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83862770
88	Myokymia (HP:0002411)	1.83223422
89	Posterior subcapsular cataract (HP:0007787)	1.83189276
90	Male pseudohermaphroditism (HP:0000037)	1.80608257
91	High anterior hairline (HP:0009890)	1.80398720
92	Conjunctival telangiectasia (HP:0000524)	1.77214561
93	Anophthalmia (HP:0000528)	1.76790386
94	Abdominal situs inversus (HP:0003363)	1.75413634
95	Abnormality of abdominal situs (HP:0011620)	1.75413634
96	Buphthalmos (HP:0000557)	1.74715960
97	Aplastic anemia (HP:0001915)	1.74709920
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73935554
99	Ureteral duplication (HP:0000073)	1.73308064
100	Thyroid-stimulating hormone excess (HP:0002925)	1.72157851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	5.81242836
2	BRAF	4.43078663
3	PIM2	4.10429468
4	TNIK	3.81752991
5	WNK4	3.16510793
6	TGFBR1	2.97091843
7	EIF2AK1	2.79475487
8	WNK1	2.79223043
9	CAMK1D	2.59644439
10	TAF1	2.43756527
11	CAMK1G	2.20775687
12	VRK2	2.13701922
13	MAP2K2	1.92450763
14	TEC	1.64088795
15	MAP3K1	1.60594090
16	MAP3K11	1.58237012
17	STK16	1.56328412
18	RAF1	1.49295190
19	MAP3K9	1.44217068
20	MAP2K6	1.37952646
21	PTK2B	1.35427028
22	PLK2	1.35284600
23	RPS6KA2	1.35208560
24	SMG1	1.34378481
25	EIF2AK3	1.32674675
26	EPHB1	1.24531786
27	TLK1	1.14751816
28	HIPK2	1.13682144
29	FRK	1.11049375
30	ZAK	1.05047014
31	DYRK2	1.03826981
32	EPHA4	1.00813747
33	PRKCI	0.98371230
34	ADRBK2	0.96847299
35	STK39	0.96352520
36	MARK2	0.95987252
37	TRIM28	0.93985195
38	ITK	0.93083890
39	PAK1	0.91138020
40	DAPK2	0.89633978
41	LRRK2	0.87645475
42	MAPK12	0.86730510
43	WNK3	0.83433198
44	CSNK1G3	0.82591790
45	BTK	0.81945275
46	NUAK1	0.81750412
47	PIK3CA	0.80269149
48	PRKAA1	0.77337632
49	RPS6KL1	0.76448444
50	RPS6KC1	0.76448444
51	RPS6KA6	0.73823132
52	PRKG2	0.73526196
53	TYRO3	0.73314752
54	BMPR1B	0.70954338
55	INSRR	0.69950155
56	ATR	0.66788309
57	GRK5	0.66100448
58	PRKAA2	0.64509994
59	TIE1	0.63811432
60	DAPK3	0.63175217
61	CSNK1G2	0.63093026
62	CSNK1A1L	0.63007844
63	EIF2AK2	0.62352105
64	AKT2	0.61542931
65	VRK1	0.59858981
66	TYK2	0.59064946
67	MAPKAPK5	0.58334411
68	NTRK1	0.57964558
69	CAMK4	0.55752695
70	STK38L	0.53577686
71	OXSR1	0.53394878
72	NEK1	0.52660747
73	PRKCQ	0.52611349
74	PDK1	0.51819686
75	CAMK1	0.50966230
76	CSNK1G1	0.46244144
77	LMTK2	0.45134842
78	IKBKB	0.44169876
79	GRK1	0.42669660
80	NLK	0.41775783
81	ADRBK1	0.41328099
82	BLK	0.40490189
83	ERBB2	0.39261131
84	NTRK2	0.37863568
85	AURKA	0.36240916
86	MAP4K2	0.36226167
87	PDPK1	0.36174947
88	MAP2K4	0.36019162
89	PRKCZ	0.34509977
90	RPS6KA5	0.34404833
91	SGK1	0.33374566
92	PAK3	0.33093452
93	STK11	0.31846666
94	PIM1	0.31347356
95	PRKCG	0.31014720
96	PRKCE	0.30691744
97	MAP3K8	0.30049616
98	MINK1	0.29656926
99	PNCK	0.29553847
100	PRKACG	0.29175910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	5.68279020
2	Arginine biosynthesis_Homo sapiens_hsa00220	5.46043226
3	Sulfur relay system_Homo sapiens_hsa04122	4.16054766
4	African trypanosomiasis_Homo sapiens_hsa05143	3.29764397
5	Ribosome_Homo sapiens_hsa03010	3.08949146
6	Tryptophan metabolism_Homo sapiens_hsa00380	3.05452099
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.79342618
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.71777854
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.64684327
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40839410
11	Phototransduction_Homo sapiens_hsa04744	2.14310864
12	Regulation of autophagy_Homo sapiens_hsa04140	1.87950384
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.87225226
14	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.70489666
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.51375160
16	Parkinsons disease_Homo sapiens_hsa05012	1.49871770
17	Caffeine metabolism_Homo sapiens_hsa00232	1.48205678
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.43435615
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.42882051
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.40550934
21	Huntingtons disease_Homo sapiens_hsa05016	1.38945904
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.35032018
23	VEGF signaling pathway_Homo sapiens_hsa04370	1.34080725
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30678442
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27431250
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26936796
27	Notch signaling pathway_Homo sapiens_hsa04330	1.22393287
28	RNA polymerase_Homo sapiens_hsa03020	1.22288946
29	Alzheimers disease_Homo sapiens_hsa05010	1.20835064
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.18238396
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.08384893
32	Fatty acid degradation_Homo sapiens_hsa00071	1.07529800
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.07043393
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.03048280
35	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98875644
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98220694
37	Basal cell carcinoma_Homo sapiens_hsa05217	0.95580779
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85103574
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.84930820
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.84013631
41	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.81057415
42	Butanoate metabolism_Homo sapiens_hsa00650	0.80261473
43	GnRH signaling pathway_Homo sapiens_hsa04912	0.77856010
44	Axon guidance_Homo sapiens_hsa04360	0.70727895
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69226490
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68920311
47	PPAR signaling pathway_Homo sapiens_hsa03320	0.67419192
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66919552
49	Pancreatic secretion_Homo sapiens_hsa04972	0.65967485
50	Homologous recombination_Homo sapiens_hsa03440	0.64952029
51	Hippo signaling pathway_Homo sapiens_hsa04390	0.64313296
52	Retinol metabolism_Homo sapiens_hsa00830	0.62246796
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58012401
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56857889
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.56490373
56	Fatty acid elongation_Homo sapiens_hsa00062	0.56484002
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.54282675
58	Bile secretion_Homo sapiens_hsa04976	0.52576219
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50366968
60	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.46537227
61	Melanogenesis_Homo sapiens_hsa04916	0.46518167
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46139886
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44399222
64	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.42054658
65	Long-term depression_Homo sapiens_hsa04730	0.41951170
66	Prolactin signaling pathway_Homo sapiens_hsa04917	0.40700203
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40523764
68	Wnt signaling pathway_Homo sapiens_hsa04310	0.39916520
69	Metabolic pathways_Homo sapiens_hsa01100	0.38122090
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38016165
71	Protein export_Homo sapiens_hsa03060	0.37292437
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37206853
73	ABC transporters_Homo sapiens_hsa02010	0.36582842
74	Tight junction_Homo sapiens_hsa04530	0.35007206
75	Morphine addiction_Homo sapiens_hsa05032	0.34550147
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34150888
77	ErbB signaling pathway_Homo sapiens_hsa04012	0.32715058
78	Long-term potentiation_Homo sapiens_hsa04720	0.31714252
79	Insulin resistance_Homo sapiens_hsa04931	0.28472070
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.26767635
81	Salivary secretion_Homo sapiens_hsa04970	0.26541260
82	Mineral absorption_Homo sapiens_hsa04978	0.25469156
83	Lysine degradation_Homo sapiens_hsa00310	0.25069177
84	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23927040
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.23800441
86	Purine metabolism_Homo sapiens_hsa00230	0.23534306
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22089923
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.21675338
89	Insulin secretion_Homo sapiens_hsa04911	0.20821974
90	Peroxisome_Homo sapiens_hsa04146	0.20734959
91	Cocaine addiction_Homo sapiens_hsa05030	0.20490241
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.20489320
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.19567137
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.17298331
95	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.15037439
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.14822457
97	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.14754018
98	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.14468363
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.14018581
100	One carbon pool by folate_Homo sapiens_hsa00670	0.14009988

IPO7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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