ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	folic acid-containing compound biosynthetic process (GO:0009396)	7.56009733
2	cysteine metabolic process (GO:0006534)	7.13327422
3	sulfur amino acid catabolic process (GO:0000098)	6.26656270
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.24992127
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.24992127
6	regulation of gonadotropin secretion (GO:0032276)	6.20948149
7	homocysteine metabolic process (GO:0050667)	5.95451564
8	regulation of plasminogen activation (GO:0010755)	5.95200857
9	IMP biosynthetic process (GO:0006188)	5.64164220
10	adenosine metabolic process (GO:0046085)	5.48994265
11	pteridine-containing compound biosynthetic process (GO:0042559)	5.22393646
12	primary amino compound metabolic process (GO:1901160)	5.18276199
13	purine nucleotide salvage (GO:0032261)	5.05694336
14	microtubule nucleation (GO:0007020)	5.05655047
15	white fat cell differentiation (GO:0050872)	5.04825121
16	L-serine metabolic process (GO:0006563)	4.89187086
17	IMP metabolic process (GO:0046040)	4.71415320
18	serine family amino acid biosynthetic process (GO:0009070)	4.37236474
19	cochlea development (GO:0090102)	4.35212634
20	inner ear receptor cell development (GO:0060119)	4.30241865
21	cartilage morphogenesis (GO:0060536)	4.29511475
22	tetrahydrofolate metabolic process (GO:0046653)	4.18258116
23	alternative mRNA splicing, via spliceosome (GO:0000380)	4.17455358
24	negative regulation of Ras GTPase activity (GO:0034261)	4.09599295
25	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.07558566
26	regulation of sequestering of triglyceride (GO:0010889)	4.04589392
27	rRNA methylation (GO:0031167)	3.96915562
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.94166768
29	negative regulation of DNA biosynthetic process (GO:2000279)	3.93700927
30	innervation (GO:0060384)	3.92912937
31	toxin transport (GO:1901998)	3.91539934
32	folic acid-containing compound metabolic process (GO:0006760)	3.89250235
33	prenylation (GO:0097354)	3.88910590
34	protein prenylation (GO:0018342)	3.88910590
35	response to lipoprotein particle (GO:0055094)	3.84829067
36	protein-chromophore linkage (GO:0018298)	3.81028140
37	regulation of endothelial cell differentiation (GO:0045601)	3.80894139
38	sulfur amino acid biosynthetic process (GO:0000097)	3.79735243
39	CENP-A containing nucleosome assembly (GO:0034080)	3.77095974
40	dicarboxylic acid biosynthetic process (GO:0043650)	3.76341420
41	acrosome assembly (GO:0001675)	3.69226736
42	auditory behavior (GO:0031223)	3.68525935
43	desmosome organization (GO:0002934)	3.65633409
44	polyamine metabolic process (GO:0006595)	3.61535775
45	chromatin remodeling at centromere (GO:0031055)	3.61525905
46	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.54309170
47	mitochondrial RNA metabolic process (GO:0000959)	3.52861344
48	regulation of chemokine secretion (GO:0090196)	3.51487946
49	positive regulation of endothelial cell differentiation (GO:0045603)	3.47889025
50	G-protein coupled receptor internalization (GO:0002031)	3.44132274
51	ribosome biogenesis (GO:0042254)	3.42422140
52	polyamine biosynthetic process (GO:0006596)	3.41736428
53	mechanosensory behavior (GO:0007638)	3.39255371
54	regulation of oxidative phosphorylation (GO:0002082)	3.31617113
55	rRNA modification (GO:0000154)	3.30737356
56	cellular response to cholesterol (GO:0071397)	3.28617698
57	pteridine-containing compound metabolic process (GO:0042558)	3.27584140
58	galactose catabolic process (GO:0019388)	3.25316938
59	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.21502619
60	purine nucleobase biosynthetic process (GO:0009113)	3.21125643
61	cellular response to sterol (GO:0036315)	3.20684894
62	leukotriene biosynthetic process (GO:0019370)	3.20479714
63	negative regulation of keratinocyte proliferation (GO:0010839)	3.19634486
64	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.17765822
65	positive regulation of histone acetylation (GO:0035066)	3.16353635
66	drug transport (GO:0015893)	3.15589706
67	pyrimidine nucleobase catabolic process (GO:0006208)	3.06655168
68	postsynaptic membrane organization (GO:0001941)	3.03451884
69	negative regulation of catenin import into nucleus (GO:0035414)	3.02817186
70	adaptation of signaling pathway (GO:0023058)	2.99103146
71	photoreceptor cell differentiation (GO:0046530)	2.98228566
72	eye photoreceptor cell differentiation (GO:0001754)	2.98228566
73	tRNA modification (GO:0006400)	2.97177665
74	protein-cofactor linkage (GO:0018065)	2.92466742
75	phosphatidylglycerol biosynthetic process (GO:0006655)	2.90568372
76	regulation of smooth muscle cell apoptotic process (GO:0034391)	2.89191761
77	negative regulation of GTP catabolic process (GO:0033125)	2.88865867
78	negative regulation of GTPase activity (GO:0034260)	2.88865867
79	sulfur amino acid metabolic process (GO:0000096)	2.87699021
80	folic acid transport (GO:0015884)	2.87284879
81	histone exchange (GO:0043486)	2.85003090
82	presynaptic membrane organization (GO:0097090)	2.84941307
83	activin receptor signaling pathway (GO:0032924)	2.83702092
84	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.82591025
85	galactose metabolic process (GO:0006012)	2.81044606
86	alpha-amino acid biosynthetic process (GO:1901607)	2.80200015
87	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79255606
88	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79255606
89	NADH dehydrogenase complex assembly (GO:0010257)	2.79255606
90	L-methionine salvage (GO:0071267)	2.77409174
91	L-methionine biosynthetic process (GO:0071265)	2.77409174
92	amino acid salvage (GO:0043102)	2.77409174
93	positive regulation of chemokine secretion (GO:0090197)	2.75773379
94	DNA replication-independent nucleosome assembly (GO:0006336)	2.75590898
95	DNA replication-independent nucleosome organization (GO:0034724)	2.75590898
96	axonemal dynein complex assembly (GO:0070286)	2.72857632
97	cytoskeleton-dependent cytokinesis (GO:0061640)	2.72417473
98	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.69359214
99	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.69359214
100	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.69359214

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.59351846
2	VDR_22108803_ChIP-Seq_LS180_Human	3.17789508
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.06982688
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.93461537
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.75310707
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73114443
7	FUS_26573619_Chip-Seq_HEK293_Human	2.50645631
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44992014
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21708701
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.08605882
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03177494
12	GBX2_23144817_ChIP-Seq_PC3_Human	1.99330024
13	BCAT_22108803_ChIP-Seq_LS180_Human	1.99169249
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96094800
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.95064243
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93879331
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.92092849
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91922387
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.90716505
20	EWS_26573619_Chip-Seq_HEK293_Human	1.89823294
21	CDX2_22108803_ChIP-Seq_LS180_Human	1.87548969
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81737554
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81664195
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80823484
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.74001278
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73792311
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72984752
28	STAT3_23295773_ChIP-Seq_U87_Human	1.70541782
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.69826183
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68548317
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66667569
32	TP53_16413492_ChIP-PET_HCT116_Human	1.66359659
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66307640
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63533551
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63478311
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.61254642
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60588367
38	P300_19829295_ChIP-Seq_ESCs_Human	1.60192213
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59238463
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56797048
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56050906
42	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.54375628
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51785177
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.50944098
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50042068
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.49043192
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48715008
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47511997
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46853139
50	AR_25329375_ChIP-Seq_VCAP_Human	1.43384969
51	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.40819334
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38001601
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.32841525
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32841525
55	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.30971524
56	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30361300
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30325300
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.29133023
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28775206
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27970656
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27644371
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.27278557
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26765005
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26169835
65	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25611776
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22921786
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22717206
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21728390
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21524212
70	ZNF274_21170338_ChIP-Seq_K562_Hela	1.20861350
71	E2F7_22180533_ChIP-Seq_HELA_Human	1.20102995
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20011454
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18614254
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18298657
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16489755
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15276675
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.13866007
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13579487
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13579487
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13204496
81	KDM2B_26808549_Chip-Seq_REH_Human	1.13117944
82	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12619084
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09852134
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08724317
85	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.07786158
86	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07268635
87	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.05668785
88	TCF4_23295773_ChIP-Seq_U87_Human	1.05397394
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04083666
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03996627
91	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03012235
92	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.01729811
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.00538179
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00419352
95	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.99495395
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98575215
97	NCOR_22424771_ChIP-Seq_293T_Human	0.97516119
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.95932608
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95188757
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95096619

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	4.69476820
2	MP0005646_abnormal_pituitary_gland	4.18919812
3	MP0005360_urolithiasis	4.10332854
4	MP0005670_abnormal_white_adipose	3.96637361
5	MP0005187_abnormal_penis_morphology	3.87346517
6	MP0002163_abnormal_gland_morphology	3.60725858
7	MP0002938_white_spotting	3.34343703
8	MP0003183_abnormal_peptide_metabolism	3.21620567
9	MP0001968_abnormal_touch/_nociception	2.95180226
10	MP0000013_abnormal_adipose_tissue	2.89284565
11	MP0003011_delayed_dark_adaptation	2.67606367
12	MP0006054_spinal_hemorrhage	2.55256563
13	MP0000372_irregular_coat_pigmentation	2.48182868
14	MP0010234_abnormal_vibrissa_follicle	2.19260178
15	MP0005171_absent_coat_pigmentation	2.01456574
16	MP0005379_endocrine/exocrine_gland_phen	1.98982689
17	MP0005551_abnormal_eye_electrophysiolog	1.93094323
18	MP0009697_abnormal_copulation	1.89819163
19	MP0000647_abnormal_sebaceous_gland	1.87580433
20	MP0008995_early_reproductive_senescence	1.81603739
21	MP0001661_extended_life_span	1.71221847
22	MP0002095_abnormal_skin_pigmentation	1.68099499
23	MP0005253_abnormal_eye_physiology	1.67414693
24	MP0003315_abnormal_perineum_morphology	1.61207993
25	MP0000613_abnormal_salivary_gland	1.59064634
26	MP0008057_abnormal_DNA_replication	1.53850969
27	MP0005248_abnormal_Harderian_gland	1.53092525
28	MP0003252_abnormal_bile_duct	1.48238194
29	MP0001502_abnormal_circadian_rhythm	1.43753942
30	MP0002638_abnormal_pupillary_reflex	1.37014652
31	MP0000631_abnormal_neuroendocrine_gland	1.32353775
32	MP0002098_abnormal_vibrissa_morphology	1.31748748
33	MP0000371_diluted_coat_color	1.28725628
34	MP0003705_abnormal_hypodermis_morpholog	1.28368597
35	MP0000747_muscle_weakness	1.26983177
36	MP0008872_abnormal_physiological_respon	1.25682001
37	MP0004885_abnormal_endolymph	1.23940904
38	MP0003942_abnormal_urinary_system	1.23112292
39	MP0002735_abnormal_chemical_nociception	1.19829226
40	MP0001764_abnormal_homeostasis	1.16477763
41	MP0002396_abnormal_hematopoietic_system	1.14119040
42	MP0002733_abnormal_thermal_nociception	1.12044571
43	MP0003935_abnormal_craniofacial_develop	1.09917890
44	MP0009053_abnormal_anal_canal	1.09264463
45	MP0005645_abnormal_hypothalamus_physiol	1.08481742
46	MP0005332_abnormal_amino_acid	1.05817813
47	MP0000534_abnormal_ureter_morphology	1.05350034
48	MP0001879_abnormal_lymphatic_vessel	1.04441863
49	MP0005084_abnormal_gallbladder_morpholo	1.03402254
50	MP0005367_renal/urinary_system_phenotyp	1.02174095
51	MP0000516_abnormal_urinary_system	1.02174095
52	MP0006292_abnormal_olfactory_placode	1.01519845
53	MP0002233_abnormal_nose_morphology	0.99416546
54	MP0004185_abnormal_adipocyte_glucose	0.97757654
55	MP0003755_abnormal_palate_morphology	0.94409027
56	MP0003937_abnormal_limbs/digits/tail_de	0.94296713
57	MP0005220_abnormal_exocrine_pancreas	0.92707311
58	MP0003868_abnormal_feces_composition	0.91414534
59	MP0005391_vision/eye_phenotype	0.91187681
60	MP0003186_abnormal_redox_activity	0.88676231
61	MP0003385_abnormal_body_wall	0.84096946
62	MP0000566_synostosis	0.83845690
63	MP0002295_abnormal_pulmonary_circulatio	0.83398096
64	MP0000163_abnormal_cartilage_morphology	0.82031305
65	MP0003806_abnormal_nucleotide_metabolis	0.80664234
66	MP0005174_abnormal_tail_pigmentation	0.77655194
67	MP0004233_abnormal_muscle_weight	0.76189251
68	MP0004147_increased_porphyrin_level	0.75633691
69	MP0005410_abnormal_fertilization	0.74297099
70	MP0001293_anophthalmia	0.73572338
71	MP0008789_abnormal_olfactory_epithelium	0.71744578
72	MP0009250_abnormal_appendicular_skeleto	0.71684812
73	MP0005319_abnormal_enzyme/_coenzyme	0.70940105
74	MP0000026_abnormal_inner_ear	0.70473530
75	MP0002160_abnormal_reproductive_system	0.67277867
76	MP0000003_abnormal_adipose_tissue	0.66447958
77	MP0002822_catalepsy	0.66100843
78	MP0002177_abnormal_outer_ear	0.65797942
79	MP0002269_muscular_atrophy	0.65736290
80	MP0005408_hypopigmentation	0.63330498
81	MP0000749_muscle_degeneration	0.61559804
82	MP0001440_abnormal_grooming_behavior	0.61447210
83	MP0005195_abnormal_posterior_eye	0.61200221
84	MP0003936_abnormal_reproductive_system	0.60533951
85	MP0004145_abnormal_muscle_electrophysio	0.60442686
86	MP0000432_abnormal_head_morphology	0.60255682
87	MP0001970_abnormal_pain_threshold	0.59865563
88	MP0002249_abnormal_larynx_morphology	0.59708264
89	MP0005085_abnormal_gallbladder_physiolo	0.59249383
90	MP0003890_abnormal_embryonic-extraembry	0.58761300
91	MP0002971_abnormal_brown_adipose	0.57768858
92	MP0005083_abnormal_biliary_tract	0.57628120
93	MP0005376_homeostasis/metabolism_phenot	0.57535287
94	MP0001944_abnormal_pancreas_morphology	0.57166245
95	MP0004133_heterotaxia	0.56990792
96	MP0004043_abnormal_pH_regulation	0.56644932
97	MP0005499_abnormal_olfactory_system	0.56332455
98	MP0005394_taste/olfaction_phenotype	0.56332455
99	MP0005636_abnormal_mineral_homeostasis	0.55175724
100	MP0000428_abnormal_craniofacial_morphol	0.54441458

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.32315381
2	Abnormality of alanine metabolism (HP:0010916)	7.32315381
3	Hyperalaninemia (HP:0003348)	7.32315381
4	Constricted visual fields (HP:0001133)	5.85676490
5	Fatigue (HP:0012378)	4.77363419
6	Congenital sensorineural hearing impairment (HP:0008527)	4.10129108
7	Action tremor (HP:0002345)	4.02899785
8	Birth length less than 3rd percentile (HP:0003561)	3.82350617
9	White forelock (HP:0002211)	3.81753223
10	Chronic hepatic failure (HP:0100626)	3.81468768
11	Long clavicles (HP:0000890)	3.70034036
12	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.61090830
13	Patchy hypopigmentation of hair (HP:0011365)	3.56830996
14	Spontaneous hematomas (HP:0007420)	3.48828027
15	Insulin-resistant diabetes mellitus (HP:0000831)	3.38659744
16	Attenuation of retinal blood vessels (HP:0007843)	3.32493724
17	Poor speech (HP:0002465)	3.25744505
18	Esophageal varix (HP:0002040)	3.22255598
19	Hypoalphalipoproteinemia (HP:0003233)	3.17353257
20	Hypopigmentation of the fundus (HP:0007894)	3.15582828
21	Progressive external ophthalmoplegia (HP:0000590)	3.10234696
22	Increased corneal curvature (HP:0100692)	3.10094368
23	Keratoconus (HP:0000563)	3.10094368
24	Abnormality of serum amino acid levels (HP:0003112)	2.98988362
25	Hyperglycemia (HP:0003074)	2.97803820
26	Pendular nystagmus (HP:0012043)	2.80396566
27	Tubulointerstitial nephritis (HP:0001970)	2.80009748
28	Large for gestational age (HP:0001520)	2.77800979
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.77505322
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.77505322
31	Absent/shortened dynein arms (HP:0200106)	2.76973019
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.76973019
33	Hyperuricemia (HP:0002149)	2.75615216
34	Increased purine levels (HP:0004368)	2.75615216
35	Progressive inability to walk (HP:0002505)	2.71569687
36	Epidermoid cyst (HP:0200040)	2.70239943
37	Abnormal umbilical cord blood vessels (HP:0011403)	2.68176443
38	Single umbilical artery (HP:0001195)	2.68176443
39	Abnormality of the fetal cardiovascular system (HP:0010948)	2.68176443
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.67375442
41	Short tibia (HP:0005736)	2.60980946
42	Abnormality of the carotid arteries (HP:0005344)	2.59758289
43	Conjugated hyperbilirubinemia (HP:0002908)	2.59703015
44	Progressive muscle weakness (HP:0003323)	2.56400061
45	Maternal diabetes (HP:0009800)	2.53077755
46	Homocystinuria (HP:0002156)	2.52913996
47	Abnormality of homocysteine metabolism (HP:0010919)	2.52913996
48	Pancreatic fibrosis (HP:0100732)	2.45616630
49	Tetany (HP:0001281)	2.44547583
50	Myocardial infarction (HP:0001658)	2.43216132
51	Conjunctival telangiectasia (HP:0000524)	2.37207967
52	Pancreatic islet-cell hyperplasia (HP:0004510)	2.35760927
53	Metaphyseal dysplasia (HP:0100255)	2.34967992
54	Premature ovarian failure (HP:0008209)	2.34593140
55	Chorioretinal atrophy (HP:0000533)	2.32012031
56	Myelomeningocele (HP:0002475)	2.30844584
57	Oligomenorrhea (HP:0000876)	2.29397725
58	Sensory axonal neuropathy (HP:0003390)	2.28259375
59	Arterial tortuosity (HP:0005116)	2.25551450
60	Increased serum pyruvate (HP:0003542)	2.24044644
61	Cone-rod dystrophy (HP:0000548)	2.16297114
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15912681
63	Hepatoblastoma (HP:0002884)	2.15845373
64	Symptomatic seizures (HP:0011145)	2.15258690
65	Inability to walk (HP:0002540)	2.10471856
66	Hypoplastic left heart (HP:0004383)	2.05492598
67	Abnormality of purine metabolism (HP:0004352)	2.02111694
68	Hyperphosphatemia (HP:0002905)	2.00963502
69	True hermaphroditism (HP:0010459)	1.99497004
70	Abnormal ciliary motility (HP:0012262)	1.99049853
71	Type II diabetes mellitus (HP:0005978)	1.97140464
72	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96900706
73	Anorexia (HP:0002039)	1.91679928
74	Toxemia of pregnancy (HP:0100603)	1.91509349
75	Hyperinsulinemic hypoglycemia (HP:0000825)	1.90555529
76	Vascular tortuosity (HP:0004948)	1.88238816
77	Abnormality of the phalanges of the hallux (HP:0010057)	1.86066811
78	Heterochromia iridis (HP:0001100)	1.82947237
79	Hypolipoproteinemia (HP:0010981)	1.82159768
80	Abnormality of glycolysis (HP:0004366)	1.81405809
81	Gout (HP:0001997)	1.80632057
82	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.80598728
83	Abnormality of the metopic suture (HP:0005556)	1.78300861
84	Cavernous hemangioma (HP:0001048)	1.78179768
85	Abnormality of the umbilical cord (HP:0010881)	1.76993522
86	Diaphragmatic weakness (HP:0009113)	1.75220705
87	Occipital encephalocele (HP:0002085)	1.73148549
88	Anencephaly (HP:0002323)	1.71482533
89	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.70872201
90	Hypoplastic scapulae (HP:0000882)	1.70872201
91	Hemiparesis (HP:0001269)	1.70741247
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.68966557
93	Proximal tubulopathy (HP:0000114)	1.68193876
94	Hypergonadotropic hypogonadism (HP:0000815)	1.68108828
95	Small hand (HP:0200055)	1.66412026
96	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.65851810
97	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.65198353
98	Arteriovenous malformation (HP:0100026)	1.64604299
99	Athetosis (HP:0002305)	1.64590148
100	Fibular hypoplasia (HP:0003038)	1.64299292

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DYRK3	4.25972478
2	MST4	3.61304416
3	MAP3K3	3.50140003
4	ACVR1B	3.00497091
5	CASK	2.83179647
6	SGK2	2.76454466
7	STK10	2.42679300
8	SGK494	2.36946208
9	SGK223	2.36946208
10	MAP4K2	2.33533090
11	RPS6KB2	2.31744949
12	TSSK6	2.27084683
13	NTRK3	2.21563514
14	AKT3	2.01192643
15	CDK9	1.86336632
16	EPHB2	1.81574532
17	MAP3K14	1.81258185
18	YES1	1.79904800
19	MAP3K4	1.77696254
20	PNCK	1.75240982
21	MAP2K7	1.70948245
22	DYRK2	1.64606298
23	PHKG1	1.57121751
24	PHKG2	1.57121751
25	ZAK	1.56344421
26	BMPR1B	1.55146519
27	SGK3	1.54721089
28	MAP2K3	1.49921067
29	MAP3K2	1.48710820
30	PRKD3	1.43869033
31	OBSCN	1.36518228
32	FGR	1.30258997
33	AKT2	1.27784614
34	JAK3	1.18776685
35	CSNK1G1	1.18628574
36	NTRK2	1.16952594
37	PLK2	1.10967334
38	TNIK	1.06352412
39	EIF2AK1	1.05493418
40	CAMK2D	0.97823586
41	CLK1	0.97076174
42	MAP2K1	0.96093445
43	ADRBK1	0.88164025
44	LIMK1	0.86173867
45	WNK1	0.85651698
46	TAOK1	0.83077652
47	GSK3A	0.78896722
48	FRK	0.77907307
49	EIF2AK3	0.77441047
50	TRPM7	0.74593884
51	CSNK1A1	0.72934405
52	SGK1	0.72109270
53	CAMK2G	0.68627117
54	RPS6KA5	0.68040576
55	NLK	0.65400098
56	PLK4	0.63966946
57	RPS6KA4	0.63923586
58	RPS6KB1	0.62211575
59	NEK6	0.60812884
60	ROCK1	0.60298419
61	CHEK1	0.56814063
62	TLK1	0.56643453
63	CAMK2B	0.55067636
64	CAMK1D	0.55045749
65	PLK1	0.53458877
66	WEE1	0.53371618
67	CAMK1	0.53274183
68	LATS1	0.50748914
69	STK3	0.49776328
70	NUAK1	0.49208831
71	CAMK4	0.48643880
72	CSNK1A1L	0.47899090
73	MKNK2	0.47770331
74	ROCK2	0.45935319
75	PRKCE	0.44595052
76	MAP2K4	0.43951938
77	CAMK2A	0.42180428
78	MAP3K8	0.41654240
79	AURKB	0.40921240
80	NEK1	0.37391152
81	CAMK1G	0.37034683
82	WNK4	0.36990507
83	BCKDK	0.36987973
84	EEF2K	0.36145020
85	TRIM28	0.35851958
86	PRKCQ	0.33363997
87	PRKCI	0.32403471
88	TAF1	0.30747549
89	PRKACB	0.30686822
90	TYK2	0.30519949
91	EIF2AK2	0.29253595
92	PLK3	0.29188000
93	AURKA	0.28787588
94	CCNB1	0.28374261
95	CSNK2A2	0.28067738
96	INSR	0.27327124
97	CSNK1E	0.27310032
98	INSRR	0.27146461
99	MAPKAPK2	0.26722846
100	DDR2	0.26697921

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	4.01487338
2	Sulfur metabolism_Homo sapiens_hsa00920	3.28574128
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.26777045
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.22210642
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.76268221
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.65784488
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.50613100
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.49632819
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.38239845
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.05381020
11	Morphine addiction_Homo sapiens_hsa05032	1.87949818
12	Basal transcription factors_Homo sapiens_hsa03022	1.87237193
13	Nicotine addiction_Homo sapiens_hsa05033	1.83392667
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79993201
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.79649284
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.76381735
17	Butanoate metabolism_Homo sapiens_hsa00650	1.69751682
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59493899
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.57952414
20	Regulation of autophagy_Homo sapiens_hsa04140	1.54471150
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.54302855
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.54152080
23	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.52207581
24	GABAergic synapse_Homo sapiens_hsa04727	1.50589080
25	Olfactory transduction_Homo sapiens_hsa04740	1.50456093
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45687111
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.44826924
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39743039
29	Sulfur relay system_Homo sapiens_hsa04122	1.37508669
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.33829421
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.27100285
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25668078
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23849459
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.23037418
35	Propanoate metabolism_Homo sapiens_hsa00640	1.22463973
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.17325647
37	RNA polymerase_Homo sapiens_hsa03020	1.16793426
38	Galactose metabolism_Homo sapiens_hsa00052	1.15911299
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.14664724
40	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.12779266
41	RNA degradation_Homo sapiens_hsa03018	1.11626092
42	Retinol metabolism_Homo sapiens_hsa00830	1.07443745
43	Serotonergic synapse_Homo sapiens_hsa04726	1.04977821
44	Taste transduction_Homo sapiens_hsa04742	1.01915517
45	Alcoholism_Homo sapiens_hsa05034	1.01395420
46	Circadian rhythm_Homo sapiens_hsa04710	0.98309448
47	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.94357209
48	Circadian entrainment_Homo sapiens_hsa04713	0.94101425
49	RNA transport_Homo sapiens_hsa03013	0.93448585
50	Carbon metabolism_Homo sapiens_hsa01200	0.92709335
51	Purine metabolism_Homo sapiens_hsa00230	0.86140066
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84370228
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.83483750
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83004450
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82330699
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.82167646
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.81491796
58	Glutathione metabolism_Homo sapiens_hsa00480	0.80858144
59	Spliceosome_Homo sapiens_hsa03040	0.80019480
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.77662349
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77226924
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.76422555
63	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.75471767
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72342020
65	Huntingtons disease_Homo sapiens_hsa05016	0.69307726
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67680570
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64105754
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63840842
69	Proteasome_Homo sapiens_hsa03050	0.63162050
70	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.62568967
71	Wnt signaling pathway_Homo sapiens_hsa04310	0.61774183
72	Adherens junction_Homo sapiens_hsa04520	0.60280080
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58503656
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54492304
75	Metabolic pathways_Homo sapiens_hsa01100	0.53670179
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52816190
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52552192
78	Folate biosynthesis_Homo sapiens_hsa00790	0.49949901
79	ABC transporters_Homo sapiens_hsa02010	0.49856381
80	Renin secretion_Homo sapiens_hsa04924	0.47917289
81	Mismatch repair_Homo sapiens_hsa03430	0.47419138
82	Fatty acid degradation_Homo sapiens_hsa00071	0.47378308
83	Cholinergic synapse_Homo sapiens_hsa04725	0.46040693
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43936932
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.43472307
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.42410973
87	Thyroid cancer_Homo sapiens_hsa05216	0.41382433
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40755774
89	Peroxisome_Homo sapiens_hsa04146	0.40735953
90	Phototransduction_Homo sapiens_hsa04744	0.39852691
91	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38370930
92	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37838632
93	Insulin secretion_Homo sapiens_hsa04911	0.37016379
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35493775
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33971816
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.32492904
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.30913174
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30189676
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29443297
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28234956

IPO7P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »