IPO8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)5.82629223
2regulation of female gonad development (GO:2000194)4.98745366
3positive regulation of chromosome segregation (GO:0051984)4.89423393
4regulation of histone H3-K9 methylation (GO:0051570)4.65863718
5protein localization to kinetochore (GO:0034501)4.56104959
6urea cycle (GO:0000050)4.53667791
7urea metabolic process (GO:0019627)4.53667791
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47841472
9L-phenylalanine catabolic process (GO:0006559)4.47841472
10cysteine metabolic process (GO:0006534)4.41900621
11regulation of acrosome reaction (GO:0060046)4.36166222
12positive regulation of histone H3-K4 methylation (GO:0051571)4.30389253
13oocyte development (GO:0048599)4.28209493
14establishment of chromosome localization (GO:0051303)4.22634207
15L-phenylalanine metabolic process (GO:0006558)4.17395380
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.17395380
17nuclear pore complex assembly (GO:0051292)4.12797423
18serine family amino acid catabolic process (GO:0009071)4.03316636
19nitrogen cycle metabolic process (GO:0071941)3.97902285
20meiotic cell cycle (GO:0051321)3.96853802
21alpha-linolenic acid metabolic process (GO:0036109)3.94892204
22aromatic amino acid family catabolic process (GO:0009074)3.93115164
23dicarboxylic acid biosynthetic process (GO:0043650)3.90837185
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87179403
25nuclear pore organization (GO:0006999)3.86823726
26mitotic chromosome condensation (GO:0007076)3.85686985
27folic acid-containing compound biosynthetic process (GO:0009396)3.85219050
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.82437773
29regulation of RNA export from nucleus (GO:0046831)3.80524638
30sulfur amino acid catabolic process (GO:0000098)3.76599376
31monoubiquitinated protein deubiquitination (GO:0035520)3.73905809
32kynurenine metabolic process (GO:0070189)3.71781875
33DNA unwinding involved in DNA replication (GO:0006268)3.69834815
34homocysteine metabolic process (GO:0050667)3.69481135
35mitotic sister chromatid cohesion (GO:0007064)3.63771828
36nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.61306611
37glycine metabolic process (GO:0006544)3.60394372
38pre-miRNA processing (GO:0031054)3.60207723
39one-carbon metabolic process (GO:0006730)3.57952790
40chromosome condensation (GO:0030261)3.57829998
41regulation of protein activation cascade (GO:2000257)3.57092744
42complement activation, alternative pathway (GO:0006957)3.56076018
43lysine catabolic process (GO:0006554)3.51603935
44lysine metabolic process (GO:0006553)3.51603935
45bile acid biosynthetic process (GO:0006699)3.48043029
46tryptophan metabolic process (GO:0006568)3.47887285
47negative regulation of fibrinolysis (GO:0051918)3.47162609
48tyrosine metabolic process (GO:0006570)3.46770908
49protein localization to chromosome, centromeric region (GO:0071459)3.45103255
50tryptophan catabolic process (GO:0006569)3.45077783
51indole-containing compound catabolic process (GO:0042436)3.45077783
52indolalkylamine catabolic process (GO:0046218)3.45077783
53protein carboxylation (GO:0018214)3.41192682
54peptidyl-glutamic acid carboxylation (GO:0017187)3.41192682
55high-density lipoprotein particle remodeling (GO:0034375)3.40678840
56negative regulation of DNA repair (GO:0045738)3.35188832
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34388010
58amino-acid betaine metabolic process (GO:0006577)3.34356348
59regulation of complement activation (GO:0030449)3.34299417
60histone phosphorylation (GO:0016572)3.31428228
61histone H2A monoubiquitination (GO:0035518)3.30103868
62membrane disassembly (GO:0030397)3.28511723
63nuclear envelope disassembly (GO:0051081)3.28511723
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.28035468
65serine family amino acid metabolic process (GO:0009069)3.24585423
66glutamate metabolic process (GO:0006536)3.22476930
67labyrinthine layer development (GO:0060711)3.21504337
68regulation of mitotic spindle organization (GO:0060236)3.21407668
69regulation of histone methylation (GO:0031060)3.19879887
70histone H2B ubiquitination (GO:0033523)3.18437731
71drug catabolic process (GO:0042737)3.16944387
72regulation of cholesterol homeostasis (GO:2000188)3.16623427
73histone H3-K9 demethylation (GO:0033169)3.15348197
74regulation of nucleobase-containing compound transport (GO:0032239)3.13260630
75positive regulation of histone methylation (GO:0031062)3.13010721
76bile acid metabolic process (GO:0008206)3.12708913
77cellular modified amino acid catabolic process (GO:0042219)3.10687180
78gene silencing by RNA (GO:0031047)3.10546030
79reverse cholesterol transport (GO:0043691)3.08609527
80nucleus organization (GO:0006997)3.07420893
81cytoplasmic mRNA processing body assembly (GO:0033962)3.07249884
82sister chromatid cohesion (GO:0007062)3.07082298
83citrulline biosynthetic process (GO:0019240)3.06636315
84regulation of fibrinolysis (GO:0051917)3.05888006
85RNA stabilization (GO:0043489)3.04945144
86mRNA stabilization (GO:0048255)3.04945144
87regulation of histone H3-K4 methylation (GO:0051569)3.04918708
88regulation of histone H3-K27 methylation (GO:0061085)3.04688344
89stress granule assembly (GO:0034063)3.03683996
90mitotic metaphase plate congression (GO:0007080)3.03297373
91regulation of sister chromatid cohesion (GO:0007063)3.02449157
92serine family amino acid biosynthetic process (GO:0009070)3.01919841
93negative regulation of histone methylation (GO:0031061)3.01235234
94interkinetic nuclear migration (GO:0022027)3.01197287
95mitotic sister chromatid segregation (GO:0000070)3.00809421
96alpha-amino acid catabolic process (GO:1901606)3.00535420
97negative regulation of histone modification (GO:0031057)3.00436090
98protein kinase C signaling (GO:0070528)2.99256514
99negative regulation of cholesterol transport (GO:0032375)2.99112820
100negative regulation of sterol transport (GO:0032372)2.99112820
101regulation of spindle organization (GO:0090224)2.98354022
102DNA packaging (GO:0006323)2.98346124
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98015047
104positive regulation of fatty acid beta-oxidation (GO:0032000)2.97754161
105female gamete generation (GO:0007292)2.96439180
106regulation of steroid hormone biosynthetic process (GO:0090030)2.96050191
107regulation of meiosis I (GO:0060631)2.95886065
108urate metabolic process (GO:0046415)2.95851182
109glyoxylate metabolic process (GO:0046487)2.94456759
110aromatic amino acid family metabolic process (GO:0009072)2.92495246
111histone H3-K36 demethylation (GO:0070544)2.92309387
112regulation of chromatin binding (GO:0035561)2.91409329
113protein localization to chromosome (GO:0034502)2.90592113
114mitotic G2/M transition checkpoint (GO:0044818)2.90361894
115bile acid and bile salt transport (GO:0015721)2.90197679
116triglyceride homeostasis (GO:0070328)2.89054528
117acylglycerol homeostasis (GO:0055090)2.89054528
118centrosome duplication (GO:0051298)2.89049351
119phospholipid homeostasis (GO:0055091)2.87783905
120attachment of spindle microtubules to kinetochore (GO:0008608)2.84529499
121regulation of fatty acid beta-oxidation (GO:0031998)2.84345081
122protein-lipid complex remodeling (GO:0034368)2.83869849
123macromolecular complex remodeling (GO:0034367)2.83869849
124plasma lipoprotein particle remodeling (GO:0034369)2.83869849
125negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.82957423
126N-terminal protein amino acid acetylation (GO:0006474)2.80467950
127cytolysis (GO:0019835)2.79449375
128phospholipid efflux (GO:0033700)2.79290093
129histone-serine phosphorylation (GO:0035404)2.79150548
130sister chromatid segregation (GO:0000819)2.78662872
131regulation of steroid hormone secretion (GO:2000831)2.77983310
132regulation of cell maturation (GO:1903429)2.77804047
133fatty acid transmembrane transport (GO:1902001)2.77674450
134histone lysine demethylation (GO:0070076)2.76875095
135cellular amino acid catabolic process (GO:0009063)2.75347649
136negative regulation of reproductive process (GO:2000242)2.75176679
137cellular ketone body metabolic process (GO:0046950)2.74973262
138positive regulation of DNA-dependent DNA replication (GO:2000105)2.74116177
139nuclear envelope organization (GO:0006998)2.73875287
140response to UV-C (GO:0010225)2.73575653
141DNA replication checkpoint (GO:0000076)2.72790477
142paraxial mesoderm development (GO:0048339)2.72374937
143regulation of hippo signaling (GO:0035330)2.71898194
144ethanol oxidation (GO:0006069)2.71766788
145negative regulation of fibroblast apoptotic process (GO:2000270)2.71270501
146pore complex assembly (GO:0046931)2.70388469
147regulation of chromosome segregation (GO:0051983)2.69388199
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67622241
149positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67622241
150positive regulation of mitotic sister chromatid separation (GO:1901970)2.67622241
151metaphase plate congression (GO:0051310)2.66920177
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.64979747
153plasma lipoprotein particle clearance (GO:0034381)2.64765588
154mitotic nuclear envelope disassembly (GO:0007077)2.64750268
155citrulline metabolic process (GO:0000052)2.64523813
156response to nitrosative stress (GO:0051409)2.63944000
157regulation of NFAT protein import into nucleus (GO:0051532)2.63239697
158positive regulation of humoral immune response (GO:0002922)2.61970619
159negative regulation of chromatin modification (GO:1903309)2.58470829
160regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56891963
161regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56891963
162positive regulation of cytokinesis (GO:0032467)2.55332381
163histone monoubiquitination (GO:0010390)2.55133379
164DNA damage induced protein phosphorylation (GO:0006975)2.55001398
165inner cell mass cell proliferation (GO:0001833)2.54846251
166regulation of double-strand break repair (GO:2000779)2.54305636
167DNA duplex unwinding (GO:0032508)2.54038869
168regulation of DNA endoreduplication (GO:0032875)2.54006675
169histone demethylation (GO:0016577)2.52383281
170establishment of mitotic spindle localization (GO:0040001)2.52262074
171activation of Rac GTPase activity (GO:0032863)2.52210176
172regulation of mitotic sister chromatid separation (GO:0010965)2.50352323
173regulation of mitotic sister chromatid segregation (GO:0033047)2.50352323
174regulation of sister chromatid segregation (GO:0033045)2.50352323
175hippo signaling (GO:0035329)2.50233692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.65306595
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.68646178
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.93016085
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.42629482
5EZH2_22144423_ChIP-Seq_EOC_Human3.94767301
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.87489783
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.77469710
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.67683992
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.46841688
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.24624006
11AR_21909140_ChIP-Seq_LNCAP_Human3.02424373
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85617058
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76411068
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75834608
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66125923
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.63195865
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.50520038
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43893648
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28257322
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21366844
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15280473
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06668432
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00120911
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.99165048
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.99165048
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.99165048
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96609439
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.87122948
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.84907883
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83037112
31CLOCK_20551151_ChIP-Seq_293T_Human1.80796819
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78219267
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67855732
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.66968183
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60189822
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59377447
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56030476
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.51701667
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51272287
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48519743
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45834242
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44044505
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43525385
44SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37974972
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.36997768
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33660460
47FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.32270117
48MYC_22102868_ChIP-Seq_BL_Human1.31820544
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31025787
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30941438
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29754325
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28782732
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28735595
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28409889
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27752838
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27461685
57TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27203335
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26754893
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26442961
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26141786
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.24797035
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24690307
63* TFEB_21752829_ChIP-Seq_HELA_Human1.24034015
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20822993
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20668273
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.20008716
67TP53_16413492_ChIP-PET_HCT116_Human1.19060181
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17721078
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17302173
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14647490
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14054718
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12336552
73GATA6_25053715_ChIP-Seq_YYC3_Human1.12046460
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10190179
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09536710
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08894081
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07139632
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06570015
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05389002
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05032939
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.04448638
82GATA1_22025678_ChIP-Seq_K562_Human1.04303639
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04175733
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04054146
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03630630
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03283538
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02513040
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02468914
89CDX2_22108803_ChIP-Seq_LS180_Human1.02066928
90PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01525795
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01477731
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01462951
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00690148
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98859346
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98859346
96POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98855462
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98848299
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.98735303
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98300654
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98180301
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98152497
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.97168223
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96110990
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95403354
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94231199
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92762041
107* BRD4_25478319_ChIP-Seq_HGPS_Human0.92007121
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91918382
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91135148
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91069550
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90248546
112* CHD1_26751641_Chip-Seq_LNCaP_Human0.90027590
113AHR_22903824_ChIP-Seq_MCF-7_Human0.89759755
114ZNF263_19887448_ChIP-Seq_K562_Human0.89640554
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89115499
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.87729353
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87562758
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87516622
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86960691
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86657516
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85964276
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85868015
123NANOG_16518401_ChIP-PET_MESCs_Mouse0.85705287
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85409426
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85284915
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85222895
127TCF7_22412390_ChIP-Seq_EML_Mouse0.84999805
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83790495
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83540216
130* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83120824
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.82763190
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82648585
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.82364528
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82071280
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.81980820
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.81890029
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.81890029
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81160591
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.80733318
140ATF3_27146783_Chip-Seq_COLON_Human0.79077505
141STAT3_23295773_ChIP-Seq_U87_Human0.78334515
142GATA4_25053715_ChIP-Seq_YYC3_Human0.77957769
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77641042
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73872276
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.72631795
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71903630
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71237670
148* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71223605
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71098167
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70351724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.10350178
2MP0005360_urolithiasis5.54941701
3MP0005365_abnormal_bile_salt4.44556996
4MP0005085_abnormal_gallbladder_physiolo4.23901433
5MP0003705_abnormal_hypodermis_morpholog3.82235932
6MP0003252_abnormal_bile_duct3.13408361
7MP0008875_abnormal_xenobiotic_pharmacok3.04112692
8MP0005451_abnormal_body_composition2.87633295
9MP0003806_abnormal_nucleotide_metabolis2.70657275
10MP0002396_abnormal_hematopoietic_system2.46787318
11MP0010329_abnormal_lipoprotein_level2.43610114
12MP0010234_abnormal_vibrissa_follicle2.19390800
13MP0010352_gastrointestinal_tract_polyps2.16104444
14MP0003868_abnormal_feces_composition2.03085147
15MP0009697_abnormal_copulation1.94395931
16MP0005076_abnormal_cell_differentiation1.93785278
17MP0002009_preneoplasia1.91820057
18MP0009840_abnormal_foam_cell1.88139085
19MP0008057_abnormal_DNA_replication1.80776525
20MP0000609_abnormal_liver_physiology1.80721186
21MP0004185_abnormal_adipocyte_glucose1.76639867
22MP0001666_abnormal_nutrient_absorption1.76143457
23MP0003111_abnormal_nucleus_morphology1.75523384
24MP0005332_abnormal_amino_acid1.71860666
25MP0010094_abnormal_chromosome_stability1.71062097
26MP0010307_abnormal_tumor_latency1.70687594
27MP0003718_maternal_effect1.65998636
28MP0003077_abnormal_cell_cycle1.65198514
29MP0003950_abnormal_plasma_membrane1.62239407
30MP0005408_hypopigmentation1.60179445
31MP0008877_abnormal_DNA_methylation1.56984571
32MP0008932_abnormal_embryonic_tissue1.55747216
33MP0005647_abnormal_sex_gland1.54650612
34MP0005409_darkened_coat_color1.53167550
35MP0002877_abnormal_melanocyte_morpholog1.52016027
36MP0005666_abnormal_adipose_tissue1.50264519
37MP0001730_embryonic_growth_arrest1.46948669
38MP0004264_abnormal_extraembryonic_tissu1.40589686
39MP0003123_paternal_imprinting1.39301823
40MP0008961_abnormal_basal_metabolism1.37860444
41MP0001915_intracranial_hemorrhage1.37834650
42MP0005083_abnormal_biliary_tract1.37619950
43MP0003890_abnormal_embryonic-extraembry1.35561024
44MP0004233_abnormal_muscle_weight1.34352980
45MP0000428_abnormal_craniofacial_morphol1.34110818
46MP0008058_abnormal_DNA_repair1.31081381
47MP0002118_abnormal_lipid_homeostasis1.28025065
48MP0003191_abnormal_cellular_cholesterol1.27484708
49MP0002138_abnormal_hepatobiliary_system1.27388250
50MP0000569_abnormal_digit_pigmentation1.27174872
51MP0010030_abnormal_orbit_morphology1.25491465
52MP0002796_impaired_skin_barrier1.23476500
53MP0008438_abnormal_cutaneous_collagen1.23251447
54MP0003941_abnormal_skin_development1.19927750
55MP0005670_abnormal_white_adipose1.19218683
56MP0004808_abnormal_hematopoietic_stem1.17745879
57MP0003699_abnormal_female_reproductive1.17117742
58MP0001672_abnormal_embryogenesis/_devel1.16941430
59MP0005380_embryogenesis_phenotype1.16941430
60MP0005621_abnormal_cell_physiology1.16784639
61MP0004130_abnormal_muscle_cell1.15975762
62MP0006292_abnormal_olfactory_placode1.15466753
63MP0003693_abnormal_embryo_hatching1.13249722
64MP0002084_abnormal_developmental_patter1.12849894
65MP0009672_abnormal_birth_weight1.12710509
66MP0004957_abnormal_blastocyst_morpholog1.11639527
67MP0000350_abnormal_cell_proliferation1.11328218
68MP0000733_abnormal_muscle_development1.11121923
69MP0002086_abnormal_extraembryonic_tissu1.09338707
70MP0005395_other_phenotype1.06942526
71MP0005187_abnormal_penis_morphology1.06629878
72MP0002166_altered_tumor_susceptibility1.06087455
73MP0000598_abnormal_liver_morphology1.05700610
74MP0001849_ear_inflammation1.04648106
75MP0002006_tumorigenesis1.00041385
76MP0002060_abnormal_skin_morphology0.98476259
77MP0001119_abnormal_female_reproductive0.97470799
78MP0003984_embryonic_growth_retardation0.97423744
79MP0002085_abnormal_embryonic_tissue0.97322027
80MP0003300_gastrointestinal_ulcer0.97193883
81MP0003183_abnormal_peptide_metabolism0.96701962
82MP0002088_abnormal_embryonic_growth/wei0.96570672
83MP0005248_abnormal_Harderian_gland0.95306027
84MP0005220_abnormal_exocrine_pancreas0.94720857
85MP0001697_abnormal_embryo_size0.93081468
86MP0000566_synostosis0.92154728
87MP0002254_reproductive_system_inflammat0.91152849
88MP0000762_abnormal_tongue_morphology0.90152339
89MP0000377_abnormal_hair_follicle0.90020327
90MP0009703_decreased_birth_body0.88232782
91MP0006138_congestive_heart_failure0.88023116
92MP0005319_abnormal_enzyme/_coenzyme0.87178178
93MP0000627_abnormal_mammary_gland0.86921305
94MP0005384_cellular_phenotype0.86747883
95MP0003566_abnormal_cell_adhesion0.86551862
96MP0005501_abnormal_skin_physiology0.86235027
97MP0010368_abnormal_lymphatic_system0.86006237
98MP0000427_abnormal_hair_cycle0.85050382
99MP0001293_anophthalmia0.83984921
100MP0002697_abnormal_eye_size0.81952728
101MP0004197_abnormal_fetal_growth/weight/0.81875894
102MP0001929_abnormal_gametogenesis0.80126878
103MP0000015_abnormal_ear_pigmentation0.80044430
104MP0000313_abnormal_cell_death0.79345983
105MP0002928_abnormal_bile_duct0.78974093
106MP0005266_abnormal_metabolism0.78512640
107MP0000678_abnormal_parathyroid_gland0.78396578
108MP0001661_extended_life_span0.77909687
109MP0000537_abnormal_urethra_morphology0.77563793
110MP0005375_adipose_tissue_phenotype0.77521380
111MP0003935_abnormal_craniofacial_develop0.77114282
112MP0002896_abnormal_bone_mineralization0.75192566
113MP0002210_abnormal_sex_determination0.74275808
114MP0004019_abnormal_vitamin_homeostasis0.73728341
115MP0002092_abnormal_eye_morphology0.73444919
116MP0002653_abnormal_ependyma_morphology0.72772264
117MP0008789_abnormal_olfactory_epithelium0.72723919
118MP0003937_abnormal_limbs/digits/tail_de0.72722955
119MP0002080_prenatal_lethality0.72208401
120MP0000432_abnormal_head_morphology0.71923004
121MP0009763_increased_sensitivity_to0.71864029
122MP0005623_abnormal_meninges_morphology0.71473714
123MP0003121_genomic_imprinting0.67937071
124MP0002161_abnormal_fertility/fecundity0.67572956
125MP0009384_cardiac_valve_regurgitation0.67570445
126MP0002971_abnormal_brown_adipose0.67494584
127MP0010678_abnormal_skin_adnexa0.66873778
128MP0005499_abnormal_olfactory_system0.65991114
129MP0005394_taste/olfaction_phenotype0.65991114
130MP0004272_abnormal_basement_membrane0.65908452
131MP0003115_abnormal_respiratory_system0.64966509
132MP0000639_abnormal_adrenal_gland0.64426211
133MP0001881_abnormal_mammary_gland0.64028575
134MP0003453_abnormal_keratinocyte_physiol0.63864811
135MP0005334_abnormal_fat_pad0.62698522
136MP0005023_abnormal_wound_healing0.61714513
137MP0002970_abnormal_white_adipose0.60463743
138MP0009643_abnormal_urine_homeostasis0.59867095
139MP0001764_abnormal_homeostasis0.59519418
140MP0002078_abnormal_glucose_homeostasis0.59227617
141MP0008007_abnormal_cellular_replicative0.58245615
142MP0003091_abnormal_cell_migration0.57811106
143MP0002019_abnormal_tumor_incidence0.57501930
144MP0009053_abnormal_anal_canal0.56996761

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.50567596
2Intrahepatic cholestasis (HP:0001406)5.39135108
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36868492
4Hypobetalipoproteinemia (HP:0003563)3.90608296
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.80981568
6Xanthomatosis (HP:0000991)3.61072921
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49788171
8Complement deficiency (HP:0004431)3.45089054
9Hypolipoproteinemia (HP:0010981)3.38239015
10Hypoalphalipoproteinemia (HP:0003233)3.32452997
11Abnormality of sulfur amino acid metabolism (HP:0004339)3.31337432
12Hyperlipoproteinemia (HP:0010980)3.09290431
13Myocardial infarction (HP:0001658)3.07972970
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07156913
15Spastic diplegia (HP:0001264)3.05422576
16Papillary thyroid carcinoma (HP:0002895)3.03647036
17Dysmetric saccades (HP:0000641)2.98018308
18Abnormality of the common coagulation pathway (HP:0010990)2.96881720
19Epidermoid cyst (HP:0200040)2.96505654
20Hypochromic microcytic anemia (HP:0004840)2.95417317
21Lip pit (HP:0100267)2.87071371
22Hyperglycinemia (HP:0002154)2.81661580
23Hepatocellular carcinoma (HP:0001402)2.81256065
24Fat malabsorption (HP:0002630)2.80424544
25Nephroblastoma (Wilms tumor) (HP:0002667)2.80342618
26Pseudobulbar signs (HP:0002200)2.79097730
27Capillary hemangiomas (HP:0005306)2.76516101
28Prolonged partial thromboplastin time (HP:0003645)2.72935725
29Abnormality of the fingertips (HP:0001211)2.72132014
30Hyperammonemia (HP:0001987)2.71277946
31Ependymoma (HP:0002888)2.67617959
32Abnormality of methionine metabolism (HP:0010901)2.66772694
33Hypoglycemic coma (HP:0001325)2.66374753
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63932364
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61157629
36Hyperglycinuria (HP:0003108)2.60395991
37Embryonal renal neoplasm (HP:0011794)2.60052402
38Flat acetabular roof (HP:0003180)2.56562458
39Osteomalacia (HP:0002749)2.54452387
40Lower limb hyperreflexia (HP:0002395)2.53794159
41Abnormality of the phalanges of the hallux (HP:0010057)2.50933906
42Volvulus (HP:0002580)2.49672839
43Overlapping toe (HP:0001845)2.49413513
44Abnormality of pyrimidine metabolism (HP:0004353)2.48409034
45Sensorimotor neuropathy (HP:0007141)2.46112769
46Abnormality of the intrinsic pathway (HP:0010989)2.45276873
47Abnormality of glycine metabolism (HP:0010895)2.44060172
48Abnormality of serine family amino acid metabolism (HP:0010894)2.44060172
49Rhabdomyosarcoma (HP:0002859)2.41016823
50Astrocytoma (HP:0009592)2.41003526
51Abnormality of the astrocytes (HP:0100707)2.41003526
52Increased nuchal translucency (HP:0010880)2.39090126
53Cubitus valgus (HP:0002967)2.38739165
54Deep philtrum (HP:0002002)2.36499754
55Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.34771796
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.34676975
57Osteolytic defects of the hand bones (HP:0009699)2.34676975
58Uterine leiomyosarcoma (HP:0002891)2.34342382
59Leiomyosarcoma (HP:0100243)2.34342382
60Abnormality of nucleobase metabolism (HP:0010932)2.34040193
61Abnormality of complement system (HP:0005339)2.33420562
62Ankle contracture (HP:0006466)2.31887351
63Spontaneous abortion (HP:0005268)2.30026646
64Transitional cell carcinoma of the bladder (HP:0006740)2.29852440
65Ketosis (HP:0001946)2.28855287
66Biliary tract neoplasm (HP:0100574)2.27180504
67Abnormality of purine metabolism (HP:0004352)2.26855773
68Esophageal varix (HP:0002040)2.25591990
69Spinal cord compression (HP:0002176)2.25511520
70Hyperglycemia (HP:0003074)2.23771983
71Urethral obstruction (HP:0000796)2.23683051
72Asymmetry of the thorax (HP:0001555)2.23327077
73Sandal gap (HP:0001852)2.22942798
74Abnormality of abdominal situs (HP:0011620)2.22308273
75Abdominal situs inversus (HP:0003363)2.22308273
76Shallow orbits (HP:0000586)2.21543735
77Impulsivity (HP:0100710)2.19359100
78Spinal cord lesions (HP:0100561)2.15759453
79Syringomyelia (HP:0003396)2.15759453
80Subacute progressive viral hepatitis (HP:0006572)2.14595575
81Acanthocytosis (HP:0001927)2.14089490
82Heterotopia (HP:0002282)2.14060416
83Bladder neoplasm (HP:0009725)2.13046807
84Bladder carcinoma (HP:0002862)2.13046807
85Hypercholesterolemia (HP:0003124)2.12518759
86Abnormal foot bone ossification (HP:0010675)2.11158952
87Cortical dysplasia (HP:0002539)2.09371058
88Supernumerary spleens (HP:0009799)2.09159080
89Male infertility (HP:0003251)2.08671438
90Hypoglycemic seizures (HP:0002173)2.08183710
91Abnormal biliary tract morphology (HP:0012440)2.08177800
92Ankyloglossia (HP:0010296)2.07906451
93Protrusio acetabuli (HP:0003179)2.02894055
94Facial hemangioma (HP:0000329)2.00975934
95Hypopigmentation of the fundus (HP:0007894)1.99594441
96Insidious onset (HP:0003587)1.98886484
97Termporal pattern (HP:0011008)1.98886484
98Abnormality of the labia minora (HP:0012880)1.98858432
99Skin nodule (HP:0200036)1.98682684
100Relative macrocephaly (HP:0004482)1.97866936
101Deep palmar crease (HP:0006191)1.97714341
102Steatorrhea (HP:0002570)1.96463927
103Acute myeloid leukemia (HP:0004808)1.95451841
104Gout (HP:0001997)1.94422628
105Deviation of the thumb (HP:0009603)1.94391113
106Periodontitis (HP:0000704)1.93044908
107Increased mean platelet volume (HP:0011877)1.91584302
108Enlarged penis (HP:0000040)1.90598274
109Neoplasm of striated muscle (HP:0009728)1.90369675
110Malnutrition (HP:0004395)1.89590925
111Shawl scrotum (HP:0000049)1.88408541
112Joint hemorrhage (HP:0005261)1.87467904
113Neoplasm of the oral cavity (HP:0100649)1.86989165
114Cafe-au-lait spot (HP:0000957)1.86426759
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85848532
116Conjunctival telangiectasia (HP:0000524)1.84416840
117Renal cell carcinoma (HP:0005584)1.84279979
118Abnormal cartilage morphology (HP:0002763)1.82350613
119Abnormality of the salivary glands (HP:0010286)1.80725924
120Abnormality of the lower motor neuron (HP:0002366)1.80584005
121Chromsome breakage (HP:0040012)1.80540919
122Abnormality of lateral ventricle (HP:0030047)1.80485386
123Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79368973
124Turricephaly (HP:0000262)1.78606542
125Aneurysm (HP:0002617)1.77986815
126Abnormality of chromosome stability (HP:0003220)1.76971697
127Hypophosphatemic rickets (HP:0004912)1.75693270
128Proximal placement of thumb (HP:0009623)1.75437798
129Depressed nasal tip (HP:0000437)1.75266236
130Cystic hygroma (HP:0000476)1.75175405
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.74090478
132Upper motor neuron abnormality (HP:0002127)1.73992027
133Thyroid carcinoma (HP:0002890)1.73738892
134Malignant gastrointestinal tract tumors (HP:0006749)1.72396378
135Gastrointestinal carcinoma (HP:0002672)1.72396378
136Microglossia (HP:0000171)1.71894108
137Embryonal neoplasm (HP:0002898)1.71461841
138Abnormality of carpal bone ossification (HP:0006257)1.70261193
139Limb hypertonia (HP:0002509)1.68249050
140Hyperinsulinemic hypoglycemia (HP:0000825)1.67154572
141Increased connective tissue (HP:0009025)1.67096358
142Long eyelashes (HP:0000527)1.66773178
143Blepharitis (HP:0000498)1.66420488
144Selective tooth agenesis (HP:0001592)1.65204214
145Long toe (HP:0010511)1.64958472
146Macroorchidism (HP:0000053)1.63923450
147Premature rupture of membranes (HP:0001788)1.63264525
148Truncal obesity (HP:0001956)1.62263391
149Delayed puberty (HP:0000823)1.61869602
150Fair hair (HP:0002286)1.61821511
151Abnormality of serum amino acid levels (HP:0003112)1.61727536
152Arterial tortuosity (HP:0005116)1.61088084
153Clitoromegaly (HP:0000057)1.59795667
154Glioma (HP:0009733)1.59095854
155Vertebral arch anomaly (HP:0008438)1.58859866
156Abnormality of oral frenula (HP:0000190)1.58126808
157Diastasis recti (HP:0001540)1.57980112
158Cholecystitis (HP:0001082)1.57803306
159Abnormal gallbladder physiology (HP:0012438)1.57803306
160Oligodactyly (hands) (HP:0001180)1.57583082
161Abnormality of chromosome segregation (HP:0002916)1.57551205
162Low anterior hairline (HP:0000294)1.56935170
163Overgrowth (HP:0001548)1.56883234
164Cranial hyperostosis (HP:0004437)1.56412239
165Increased purine levels (HP:0004368)1.56246941
166Hyperuricemia (HP:0002149)1.56246941
167Enlarged kidneys (HP:0000105)1.56088851
168Stillbirth (HP:0003826)1.55964347
169Uterine neoplasm (HP:0010784)1.55447470
170Vascular tortuosity (HP:0004948)1.53644368
171Abnormal ossification of hand bones (HP:0005921)1.51178124
172Apathy (HP:0000741)1.50230149
173Complete atrioventricular canal defect (HP:0001674)1.49447444
174Gonadotropin excess (HP:0000837)1.49040946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.47026671
2LATS23.11449056
3CDK123.09270175
4CDC72.71498163
5EEF2K2.60197177
6PKN22.60174974
7ARAF2.58892513
8STK38L2.56759655
9STK102.48836418
10ERBB42.27940480
11STK242.16893506
12STK32.16596290
13TAOK32.01421939
14TRIB31.99428754
15ICK1.86627732
16TTK1.84045327
17NEK91.83363267
18BRAF1.81167040
19FRK1.77241686
20SMG11.75892223
21SIK11.68325430
22KSR21.66150448
23NEK61.63255484
24MAP3K61.59048081
25PRPF4B1.58682982
26PRKD31.51304776
27MAP3K131.49122382
28CAMK1D1.44720539
29MUSK1.43666745
30MOS1.42204174
31NEK21.40095963
32DMPK1.39926436
33MAP3K91.32069432
34FGFR21.24374357
35MAP3K141.22428700
36FGFR41.18726089
37WNK11.18594053
38PTK61.18520659
39MARK31.15395818
40CDK61.11688461
41STK381.08133414
42KSR11.07743167
43MELK1.06721770
44PTK21.06474146
45MAP3K81.04722927
46RET0.99544586
47CDK40.99358576
48MAP3K40.99299223
49PDGFRA0.98390909
50TAOK10.97688129
51TRPM70.95554620
52FGFR30.95070208
53RIPK10.93897146
54MTOR0.92176432
55FLT30.91387014
56MAPK110.91340087
57BCKDK0.90159523
58NEK10.89362195
59MST40.89051193
60SGK30.88092057
61RPS6KB20.87923030
62TYRO30.86638796
63PLK40.86054258
64JAK30.84614587
65CDK90.82600886
66MAPKAPK30.77903066
67MAP2K40.77127556
68CSNK1D0.77039646
69AURKA0.76975215
70AURKB0.76315240
71PAK60.75699763
72ATM0.75604299
73BRD40.75421564
74NUAK10.75319773
75TNIK0.74518225
76PRKAA20.74369267
77CHEK20.74095846
78PDGFRB0.73321574
79AKT30.73241865
80SGK20.72785312
81PRKAA10.72224317
82EIF2AK30.72142147
83CHEK10.71487347
84YES10.70467002
85EIF2AK10.69189157
86PLK30.69147138
87BRSK10.68809572
88CAMK1G0.68526391
89ATR0.64275753
90ALK0.64186902
91CSNK1G10.63446027
92JAK20.63259446
93PLK10.63254322
94TTN0.62561487
95RAF10.62236306
96TSSK60.60563853
97MAP3K50.59703281
98MAP3K100.55665536
99MST1R0.55590828
100TYK20.55143490
101SCYL20.55119216
102SRPK10.52965199
103ERBB20.52584871
104BUB10.52114461
105CDK20.51805318
106PBK0.50460042
107JAK10.50144504
108CLK10.49700165
109NLK0.48360008
110NTRK10.48092143
111TAF10.47725341
112EPHA20.47673379
113CSNK1G20.46766760
114PIM10.45905882
115CDK70.41752363
116WEE10.41614551
117PAK40.41487042
118MET0.41002932
119AKT20.40992988
120ERN10.40025390
121ABL20.39750304
122PAK20.39733423
123CDK10.39270861
124CDK80.39047800
125FGFR10.38987407
126ABL10.38760193
127MAPK140.37876672
128CSNK1E0.36926350
129MKNK10.36719602
130PRKCI0.36247911
131LRRK20.35838787
132BRSK20.34394144
133MAP3K10.34150658
134PNCK0.34090451
135STK40.33832278
136PASK0.33507550
137MAPK100.33212763
138EIF2AK20.32629089
139CHUK0.32310719
140MAP3K70.31930369

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.21475303
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.38801088
3Arginine biosynthesis_Homo sapiens_hsa002203.09295963
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87304815
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81068104
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.26639602
7Fatty acid degradation_Homo sapiens_hsa000712.22252027
8Complement and coagulation cascades_Homo sapiens_hsa046102.12553643
9Tryptophan metabolism_Homo sapiens_hsa003802.08144512
10Selenocompound metabolism_Homo sapiens_hsa004501.96462736
11Lysine degradation_Homo sapiens_hsa003101.94174862
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90962116
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89160852
14Mismatch repair_Homo sapiens_hsa034301.78944265
15DNA replication_Homo sapiens_hsa030301.76849751
16PPAR signaling pathway_Homo sapiens_hsa033201.68179509
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67935927
18mRNA surveillance pathway_Homo sapiens_hsa030151.67740277
19Fatty acid metabolism_Homo sapiens_hsa012121.59512287
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59033764
21Fatty acid biosynthesis_Homo sapiens_hsa000611.56407253
22One carbon pool by folate_Homo sapiens_hsa006701.53870929
23Butanoate metabolism_Homo sapiens_hsa006501.52766817
24Bile secretion_Homo sapiens_hsa049761.47845167
25Basal transcription factors_Homo sapiens_hsa030221.44953657
26Peroxisome_Homo sapiens_hsa041461.43597880
27Caffeine metabolism_Homo sapiens_hsa002321.42848306
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.42149740
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41613843
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41268424
31Renal cell carcinoma_Homo sapiens_hsa052111.41023515
32Biosynthesis of amino acids_Homo sapiens_hsa012301.40489048
33Propanoate metabolism_Homo sapiens_hsa006401.32401913
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25009562
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23959028
36Proteoglycans in cancer_Homo sapiens_hsa052051.23251718
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17585430
38Acute myeloid leukemia_Homo sapiens_hsa052211.16380377
39Nucleotide excision repair_Homo sapiens_hsa034201.14784453
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.14156619
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13618270
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12663728
43Glioma_Homo sapiens_hsa052141.12414189
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11319352
45Gap junction_Homo sapiens_hsa045401.08834052
46B cell receptor signaling pathway_Homo sapiens_hsa046621.07983110
47Focal adhesion_Homo sapiens_hsa045101.07727246
48ErbB signaling pathway_Homo sapiens_hsa040121.07720021
49Staphylococcus aureus infection_Homo sapiens_hsa051501.05213437
50beta-Alanine metabolism_Homo sapiens_hsa004101.03100295
51Tyrosine metabolism_Homo sapiens_hsa003501.01626482
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01106394
53Base excision repair_Homo sapiens_hsa034101.00236328
54Retinol metabolism_Homo sapiens_hsa008301.00132501
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.99705146
56ABC transporters_Homo sapiens_hsa020100.98900651
57Chemical carcinogenesis_Homo sapiens_hsa052040.97711383
58Hepatitis B_Homo sapiens_hsa051610.96786449
59Cell cycle_Homo sapiens_hsa041100.96197464
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95076055
61Viral carcinogenesis_Homo sapiens_hsa052030.91269946
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90824964
63Starch and sucrose metabolism_Homo sapiens_hsa005000.89585745
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.88672117
65Histidine metabolism_Homo sapiens_hsa003400.87548777
66Carbon metabolism_Homo sapiens_hsa012000.87479292
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87217293
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86622448
69Long-term potentiation_Homo sapiens_hsa047200.86334245
70Insulin resistance_Homo sapiens_hsa049310.83886814
71Phenylalanine metabolism_Homo sapiens_hsa003600.83823684
72Prion diseases_Homo sapiens_hsa050200.83776950
73mTOR signaling pathway_Homo sapiens_hsa041500.83364604
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82331902
75Amoebiasis_Homo sapiens_hsa051460.82096849
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.79940543
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.78774512
78VEGF signaling pathway_Homo sapiens_hsa043700.77444609
79HTLV-I infection_Homo sapiens_hsa051660.76150903
80Circadian rhythm_Homo sapiens_hsa047100.75957381
81Folate biosynthesis_Homo sapiens_hsa007900.74944688
82Glucagon signaling pathway_Homo sapiens_hsa049220.74601197
83MicroRNAs in cancer_Homo sapiens_hsa052060.73558914
84Notch signaling pathway_Homo sapiens_hsa043300.72798258
85Hippo signaling pathway_Homo sapiens_hsa043900.72599780
86Dorso-ventral axis formation_Homo sapiens_hsa043200.72587172
87ECM-receptor interaction_Homo sapiens_hsa045120.72252610
88Spliceosome_Homo sapiens_hsa030400.72111781
89Pathways in cancer_Homo sapiens_hsa052000.70209186
90Fat digestion and absorption_Homo sapiens_hsa049750.69787880
91Estrogen signaling pathway_Homo sapiens_hsa049150.69705142
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68656303
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.66758485
94Tight junction_Homo sapiens_hsa045300.66244583
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.65943273
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65872913
97Homologous recombination_Homo sapiens_hsa034400.65785007
98HIF-1 signaling pathway_Homo sapiens_hsa040660.65434475
99Vitamin B6 metabolism_Homo sapiens_hsa007500.65056418
100Herpes simplex infection_Homo sapiens_hsa051680.63562913
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63383109
102Ovarian steroidogenesis_Homo sapiens_hsa049130.63237114
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62937932
104Pyruvate metabolism_Homo sapiens_hsa006200.62384642
105Fanconi anemia pathway_Homo sapiens_hsa034600.61794612
106AMPK signaling pathway_Homo sapiens_hsa041520.61193107
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60470223
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.60043215
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59764111
110Pentose phosphate pathway_Homo sapiens_hsa000300.59752276
111Melanoma_Homo sapiens_hsa052180.59322368
112Sulfur relay system_Homo sapiens_hsa041220.59312983
113Endometrial cancer_Homo sapiens_hsa052130.57987000
114Pancreatic cancer_Homo sapiens_hsa052120.56661227
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56023067
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55754962
117Wnt signaling pathway_Homo sapiens_hsa043100.55710927
118Adherens junction_Homo sapiens_hsa045200.54884769
119GnRH signaling pathway_Homo sapiens_hsa049120.54115678
120Glycerolipid metabolism_Homo sapiens_hsa005610.53312051
121Melanogenesis_Homo sapiens_hsa049160.53065924
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.52935054
123p53 signaling pathway_Homo sapiens_hsa041150.52513826
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52459425
125Sulfur metabolism_Homo sapiens_hsa009200.51900566
126Long-term depression_Homo sapiens_hsa047300.51518137
127Non-small cell lung cancer_Homo sapiens_hsa052230.51274869
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51082157
129Thyroid cancer_Homo sapiens_hsa052160.50082477
130TGF-beta signaling pathway_Homo sapiens_hsa043500.49793690
131Insulin signaling pathway_Homo sapiens_hsa049100.49377782
132Thyroid hormone synthesis_Homo sapiens_hsa049180.48970793
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48795483
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.47937955
135Arginine and proline metabolism_Homo sapiens_hsa003300.46704910
136T cell receptor signaling pathway_Homo sapiens_hsa046600.45592071
137RNA degradation_Homo sapiens_hsa030180.45331499
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45010126
139Apoptosis_Homo sapiens_hsa042100.44898515
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44822226
141Prolactin signaling pathway_Homo sapiens_hsa049170.42790936
142Chronic myeloid leukemia_Homo sapiens_hsa052200.41034239
143Vitamin digestion and absorption_Homo sapiens_hsa049770.40835335
144Non-homologous end-joining_Homo sapiens_hsa034500.40355818
145RNA transport_Homo sapiens_hsa030130.40024979
146Steroid biosynthesis_Homo sapiens_hsa001000.36733759
147Small cell lung cancer_Homo sapiens_hsa052220.36708982
148Colorectal cancer_Homo sapiens_hsa052100.36167481
149Prostate cancer_Homo sapiens_hsa052150.35458439
150FoxO signaling pathway_Homo sapiens_hsa040680.33860759
151Inositol phosphate metabolism_Homo sapiens_hsa005620.33337940
152Choline metabolism in cancer_Homo sapiens_hsa052310.32965875
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31773693
154Oocyte meiosis_Homo sapiens_hsa041140.31389980
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31104410
156Systemic lupus erythematosus_Homo sapiens_hsa053220.30681237
157Bladder cancer_Homo sapiens_hsa052190.30185879
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28517060
159Type II diabetes mellitus_Homo sapiens_hsa049300.28408822

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