IPO8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleoside monophosphate metabolic process (GO:0009129)9.29265643
2pentose-phosphate shunt (GO:0006098)7.98591725
3CTP metabolic process (GO:0046036)7.66987935
4CTP biosynthetic process (GO:0006241)7.66987935
5NADPH regeneration (GO:0006740)7.66581390
6pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)7.14536012
7keratinocyte development (GO:0003334)7.00932797
8pentose metabolic process (GO:0019321)6.93162520
9diterpenoid biosynthetic process (GO:0016102)6.90350070
10pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)6.62088569
11purine nucleotide salvage (GO:0032261)6.32267124
12pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)6.21514656
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.09004856
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.09004856
15glucose catabolic process (GO:0006007)5.80902021
16pyrimidine ribonucleoside biosynthetic process (GO:0046132)5.66179052
17cellular metabolic compound salvage (GO:0043094)5.51049423
18activation of NF-kappaB-inducing kinase activity (GO:0007250)5.50170606
19pyrimidine nucleoside triphosphate metabolic process (GO:0009147)5.49740129
20pyrimidine ribonucleotide biosynthetic process (GO:0009220)5.43077693
21terpenoid biosynthetic process (GO:0016114)5.40380777
22purine nucleobase biosynthetic process (GO:0009113)5.20465079
23centrosome duplication (GO:0051298)5.14872546
24negative regulation of JAK-STAT cascade (GO:0046426)5.12352849
25negative regulation of keratinocyte proliferation (GO:0010839)5.09843599
26DNA ligation (GO:0006266)5.00437666
27pyrimidine ribonucleotide metabolic process (GO:0009218)4.83667541
28regulation of activation of Janus kinase activity (GO:0010533)4.66505749
29positive regulation of NIK/NF-kappaB signaling (GO:1901224)4.64980293
30regulation of glycogen (starch) synthase activity (GO:2000465)4.57642869
31nucleobase biosynthetic process (GO:0046112)4.38577621
32pyrimidine nucleotide biosynthetic process (GO:0006221)4.34477765
33tRNA modification (GO:0006400)4.30448249
34peptidyl-cysteine modification (GO:0018198)4.28402278
35peptidyl-lysine dimethylation (GO:0018027)4.24016263
36pyrimidine nucleoside biosynthetic process (GO:0046134)4.12413257
37regulation of NIK/NF-kappaB signaling (GO:1901222)4.01864127
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.94304535
39pyrimidine ribonucleoside metabolic process (GO:0046131)3.83303191
40DNA synthesis involved in DNA repair (GO:0000731)3.74612474
41interleukin-6-mediated signaling pathway (GO:0070102)3.73257797
42neutrophil mediated immunity (GO:0002446)3.67126014
43response to nitric oxide (GO:0071731)3.63479585
44translesion synthesis (GO:0019985)3.62620828
45response to folic acid (GO:0051593)3.61388125
46AMP metabolic process (GO:0046033)3.54265784
47catecholamine transport (GO:0051937)3.52827373
48positive regulation of epidermal cell differentiation (GO:0045606)3.49893779
49retinal metabolic process (GO:0042574)3.46409970
50pyrimidine-containing compound biosynthetic process (GO:0072528)3.44938127
51negative regulation of stem cell proliferation (GO:2000647)3.43142912
52non-recombinational repair (GO:0000726)3.35605417
53double-strand break repair via nonhomologous end joining (GO:0006303)3.35605417
54NADP metabolic process (GO:0006739)3.31331997
55amino acid salvage (GO:0043102)3.21417349
56L-methionine salvage (GO:0071267)3.21417349
57L-methionine biosynthetic process (GO:0071265)3.21417349
58grooming behavior (GO:0007625)3.19777109
59purine-containing compound salvage (GO:0043101)3.09066873
60protein-chromophore linkage (GO:0018298)3.07890231
61DNA dealkylation (GO:0035510)3.05149070
62establishment of skin barrier (GO:0061436)3.04498168
63pyrimidine nucleotide metabolic process (GO:0006220)2.98570869
64polyketide metabolic process (GO:0030638)2.93470811
65doxorubicin metabolic process (GO:0044598)2.93470811
66daunorubicin metabolic process (GO:0044597)2.93470811
67translational elongation (GO:0006414)2.92664462
68postreplication repair (GO:0006301)2.91330645
69heparin metabolic process (GO:0030202)2.90954418
70heparin biosynthetic process (GO:0030210)2.90954418
71negative regulation of interleukin-8 production (GO:0032717)2.88147575
72myeloid leukocyte mediated immunity (GO:0002444)2.87952756
73telomere maintenance via semi-conservative replication (GO:0032201)2.87569421
74regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80782621
75ribonucleoside monophosphate biosynthetic process (GO:0009156)2.79270345
76translational termination (GO:0006415)2.78685322
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77302731
78regulation of spindle organization (GO:0090224)2.72142417
79hexose catabolic process (GO:0019320)2.70258894
80extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.69952226
81tRNA processing (GO:0008033)2.67033533
82ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67011377
83aminoglycoside antibiotic metabolic process (GO:0030647)2.65059372
84peroxisome fission (GO:0016559)2.61026860
85viral transcription (GO:0019083)2.60871153
86cytokinetic process (GO:0032506)2.60683994
87pyrimidine nucleoside metabolic process (GO:0006213)2.57044432
88nucleoside monophosphate biosynthetic process (GO:0009124)2.55748052
89positive regulation of actin filament depolymerization (GO:0030836)2.53031975
90regulation of translational termination (GO:0006449)2.52807271
91isoprenoid biosynthetic process (GO:0008299)2.52315160
92nucleotide salvage (GO:0043173)12.7342381
93pyrimidine-containing compound salvage (GO:0008655)12.7067595
94pyrimidine nucleoside salvage (GO:0043097)12.7067595
95nucleoside salvage (GO:0043174)12.0276863
96pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)11.9769351
97UMP biosynthetic process (GO:0006222)11.9769351
98pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)11.9769351
99UMP metabolic process (GO:0046049)11.9769351
100pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)10.0923969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60481321
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.14084335
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62305814
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.05440135
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00981988
6ELK1_19687146_ChIP-ChIP_HELA_Human2.81266732
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.77405969
8POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.67299153
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.54668486
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47094656
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.44689594
12TAF15_26573619_Chip-Seq_HEK293_Human2.43260627
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.35344625
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34476836
15IGF1R_20145208_ChIP-Seq_DFB_Human2.19372921
16POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.12612272
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10776117
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02315194
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98047402
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94788297
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91988573
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83936166
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.80439474
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.79768095
25IRF1_19129219_ChIP-ChIP_H3396_Human1.79477373
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70917412
27FUS_26573619_Chip-Seq_HEK293_Human1.66730913
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64795852
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63671079
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.59569058
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59499510
32GBX2_23144817_ChIP-Seq_PC3_Human1.57462944
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.57074005
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55088824
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53860945
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50808330
37P300_19829295_ChIP-Seq_ESCs_Human1.48374440
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48108297
39ZNF274_21170338_ChIP-Seq_K562_Hela1.46728506
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45105222
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.42420171
42P53_22127205_ChIP-Seq_FIBROBLAST_Human1.40365349
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39848026
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.38384367
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.38147377
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37695512
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37180183
48VDR_23849224_ChIP-Seq_CD4+_Human1.34340999
49HTT_18923047_ChIP-ChIP_STHdh_Human1.32612933
50VDR_22108803_ChIP-Seq_LS180_Human1.30468491
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30161336
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30008558
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.28506951
54SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25727829
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24106351
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20441161
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19932901
58EWS_26573619_Chip-Seq_HEK293_Human1.17638783
59BCAT_22108803_ChIP-Seq_LS180_Human1.16971210
60CBP_20019798_ChIP-Seq_JUKART_Human1.16243730
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16243730
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.14429418
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13830276
64FOXP3_21729870_ChIP-Seq_TREG_Human1.13489487
65TP53_22573176_ChIP-Seq_HFKS_Human1.13011487
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12165938
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.10652286
68JUN_21703547_ChIP-Seq_K562_Human1.08250578
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.07151999
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05746576
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.05466347
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04262915
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04232924
74NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03718027
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03410877
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02243470
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01942181
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01401501
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01171289
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98963779
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97789285
82SRF_21415370_ChIP-Seq_HL-1_Mouse0.96780149
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.96760896
84SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96456142
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95675161
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95204264
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95204133
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94505547
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94129045
90NANOG_19829295_ChIP-Seq_ESCs_Human0.93148885
91SOX2_19829295_ChIP-Seq_ESCs_Human0.93148885
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93101129
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93101129
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93101129
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92867143
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.92601252
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92497492
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91589812
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.90677240
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90455801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology6.32478471
2MP0001348_abnormal_lacrimal_gland4.03000100
3MP0001346_abnormal_lacrimal_gland3.94383913
4MP0003806_abnormal_nucleotide_metabolis3.87197925
5MP0005379_endocrine/exocrine_gland_phen3.69146798
6MP0003950_abnormal_plasma_membrane3.68227261
7MP0000372_irregular_coat_pigmentation3.14164055
8MP0008875_abnormal_xenobiotic_pharmacok2.98439970
9MP0010094_abnormal_chromosome_stability2.58560133
10MP0000538_abnormal_urinary_bladder2.57683312
11MP0001873_stomach_inflammation2.56943121
12MP0003646_muscle_fatigue2.54245485
13MP0006292_abnormal_olfactory_placode2.50811054
14MP0002234_abnormal_pharynx_morphology2.50671553
15MP0005360_urolithiasis2.19202132
16MP0003724_increased_susceptibility_to2.11210385
17MP0008872_abnormal_physiological_respon2.03392541
18MP0000383_abnormal_hair_follicle1.89183459
19MP0005167_abnormal_blood-brain_barrier1.89124869
20MP0006082_CNS_inflammation1.78385565
21MP0003279_aneurysm1.75976502
22MP0008058_abnormal_DNA_repair1.75549458
23MP0010678_abnormal_skin_adnexa1.70983010
24MP0008057_abnormal_DNA_replication1.66017276
25MP0005171_absent_coat_pigmentation1.57258912
26MP0006072_abnormal_retinal_apoptosis1.56307017
27MP0005310_abnormal_salivary_gland1.55205972
28MP0003119_abnormal_digestive_system1.53005147
29MP0001529_abnormal_vocalization1.51968071
30MP0009697_abnormal_copulation1.47145478
31MP0002938_white_spotting1.45783623
32MP0002638_abnormal_pupillary_reflex1.45308121
33MP0005503_abnormal_tendon_morphology1.44126789
34MP0001293_anophthalmia1.41779205
35MP0003693_abnormal_embryo_hatching1.36148321
36MP0004147_increased_porphyrin_level1.34084625
37MP0008877_abnormal_DNA_methylation1.33055203
38MP0010386_abnormal_urinary_bladder1.25588649
39MP0000751_myopathy1.21807535
40MP0004957_abnormal_blastocyst_morpholog1.21416910
41MP0002102_abnormal_ear_morphology1.19252290
42MP0000467_abnormal_esophagus_morphology1.17304380
43MP0003077_abnormal_cell_cycle1.17165591
44MP0006054_spinal_hemorrhage1.17070995
45MP0003567_abnormal_fetal_cardiomyocyte1.14734532
46MP0008873_increased_physiological_sensi1.12963640
47MP0003315_abnormal_perineum_morphology1.11953797
48MP0000613_abnormal_salivary_gland1.11367899
49MP0002095_abnormal_skin_pigmentation1.10658987
50MP0001756_abnormal_urination1.03216469
51MP0003195_calcinosis1.02797754
52MP0008932_abnormal_embryonic_tissue0.97146461
53MP0005084_abnormal_gallbladder_morpholo0.94474608
54MP0002933_joint_inflammation0.91963822
55MP0005408_hypopigmentation0.90935617
56MP0001663_abnormal_digestive_system0.90005705
57MP0005165_increased_susceptibility_to0.86757588
58MP0006276_abnormal_autonomic_nervous0.84972956
59MP0005075_abnormal_melanosome_morpholog0.84181628
60MP0000749_muscle_degeneration0.83384904
61MP0001177_atelectasis0.83129179
62MP0004036_abnormal_muscle_relaxation0.82805296
63MP0002751_abnormal_autonomic_nervous0.82496513
64MP0002108_abnormal_muscle_morphology0.82258319
65MP0003890_abnormal_embryonic-extraembry0.81168882
66MP0000647_abnormal_sebaceous_gland0.80385267
67MP0003718_maternal_effect0.80074626
68MP0003136_yellow_coat_color0.79574476
69MP0010234_abnormal_vibrissa_follicle0.78061219
70MP0002932_abnormal_joint_morphology0.76052342
71MP0002090_abnormal_vision0.74649278
72MP0009250_abnormal_appendicular_skeleto0.74560187
73MP0010329_abnormal_lipoprotein_level0.74222420
74MP0002277_abnormal_respiratory_mucosa0.71422607
75MP0003787_abnormal_imprinting0.70588638
76MP0001664_abnormal_digestion0.69018927
77MP0003943_abnormal_hepatobiliary_system0.68210856
78MP0002160_abnormal_reproductive_system0.66259079
79MP0001944_abnormal_pancreas_morphology0.64487200
80MP0002837_dystrophic_cardiac_calcinosis0.63571651
81MP0001286_abnormal_eye_development0.63032991
82MP0002396_abnormal_hematopoietic_system0.61968394
83MP0008770_decreased_survivor_rate0.61361422
84MP0001299_abnormal_eye_distance/0.61289335
85MP0005266_abnormal_metabolism0.60383529
86MP0003123_paternal_imprinting0.60001470
87MP0005381_digestive/alimentary_phenotyp0.57578745
88MP0001188_hyperpigmentation0.57485311
89MP0005257_abnormal_intraocular_pressure0.57334824
90MP0001905_abnormal_dopamine_level0.56928931
91MP0003880_abnormal_central_pattern0.56011499
92MP0003111_abnormal_nucleus_morphology0.55620622
93MP0004215_abnormal_myocardial_fiber0.54308233
94MP0004085_abnormal_heartbeat0.54179885
95MP0001191_abnormal_skin_condition0.54001775
96MP0002184_abnormal_innervation0.51652394
97MP0005253_abnormal_eye_physiology0.50760332
98MP0001879_abnormal_lymphatic_vessel0.50696009
99MP0002233_abnormal_nose_morphology0.48899395
100MP0003252_abnormal_bile_duct0.48314929

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)8.77716253
2Hip dysplasia (HP:0001385)7.75717501
3Abnormality of the pons (HP:0007361)7.17332636
4Hypoplasia of the pons (HP:0012110)6.77777392
5Achilles tendon contracture (HP:0001771)6.30881463
6Abnormality of the Achilles tendon (HP:0005109)5.66123727
7Hip contracture (HP:0003273)5.28337540
8Opisthotonus (HP:0002179)5.03628109
9Poor suck (HP:0002033)4.92137872
10Limited hip movement (HP:0008800)4.77751346
11Hyperglycinemia (HP:0002154)3.77145016
12Dyskinesia (HP:0100660)3.50013293
13Scapular winging (HP:0003691)3.49104473
14Carpal bone hypoplasia (HP:0001498)3.45248719
15Degeneration of anterior horn cells (HP:0002398)3.37631310
16Abnormality of the anterior horn cell (HP:0006802)3.37631310
17Knee flexion contracture (HP:0006380)3.34957833
18Gowers sign (HP:0003391)3.29431249
19Abnormality of chromosome stability (HP:0003220)3.29424988
20Poor eye contact (HP:0000817)3.21015409
21Impaired smooth pursuit (HP:0007772)3.08408523
22Increased hepatocellular lipid droplets (HP:0006565)2.92919933
23Rhabdomyosarcoma (HP:0002859)2.88819873
24Abnormal biliary tract physiology (HP:0012439)2.86739616
25Bile duct proliferation (HP:0001408)2.86739616
26Abnormality of the shoulder girdle musculature (HP:0001435)2.86024758
27Supernumerary spleens (HP:0009799)2.84155909
28Fasciculations (HP:0002380)2.71827219
29Asplenia (HP:0001746)2.70228223
30Prominent metopic ridge (HP:0005487)2.63209313
31Spondylolisthesis (HP:0003302)2.59672514
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.59472421
33Parakeratosis (HP:0001036)2.58565115
34Restlessness (HP:0000711)2.58391443
35Lipid accumulation in hepatocytes (HP:0006561)2.54381503
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52951850
37Brushfield spots (HP:0001088)2.35242101
38Fibular aplasia (HP:0002990)2.33917313
39Potter facies (HP:0002009)2.31268115
40Facial shape deformation (HP:0011334)2.31268115
41Autoimmune thrombocytopenia (HP:0001973)2.27097539
42Death in childhood (HP:0003819)2.25962497
43Wide intermamillary distance (HP:0006610)2.25638221
44Abnormality of the metopic suture (HP:0005556)2.24712715
45Mesomelia (HP:0003027)2.24022335
46Symphalangism affecting the phalanges of the hand (HP:0009773)2.23685200
47Abnormal social behavior (HP:0012433)2.15691811
48Impaired social interactions (HP:0000735)2.15691811
49Waddling gait (HP:0002515)2.15690968
50Renal Fanconi syndrome (HP:0001994)2.14994733
51Long clavicles (HP:0000890)2.13991839
52Small epiphyses (HP:0010585)2.12167630
53Severe global developmental delay (HP:0011344)2.11131302
54Aplasia/Hypoplasia of the fibula (HP:0006492)2.10897286
55Progressive microcephaly (HP:0000253)2.07464143
56Nasal speech (HP:0001611)2.04692361
57Irregular epiphyses (HP:0010582)2.02894460
58Sacral dimple (HP:0000960)2.02727546
59Abnormality of the periventricular white matter (HP:0002518)2.02519940
60Thick nail (HP:0001805)2.00129839
61Tubular atrophy (HP:0000092)1.99038857
62Broad ribs (HP:0000885)1.95894027
63Congenital, generalized hypertrichosis (HP:0004540)1.90731136
64Female pseudohermaphroditism (HP:0010458)1.89879999
65Abnormality of ocular smooth pursuit (HP:0000617)1.88968269
66Abnormality of the vocal cords (HP:0008777)1.87612416
67Clubbing of toes (HP:0100760)1.86882572
68Submucous cleft hard palate (HP:0000176)1.85071249
69Neoplasm of head and neck (HP:0012288)1.82782709
70Esophageal neoplasm (HP:0100751)1.82782709
71Progressive hearing impairment (HP:0001730)1.81150819
72Urethral obstruction (HP:0000796)1.80982448
73Abnormal drinking behavior (HP:0030082)1.80547634
74Polydipsia (HP:0001959)1.80547634
75Pancreatic cysts (HP:0001737)1.80170676
76Adrenal hypoplasia (HP:0000835)1.78683421
77Acute necrotizing encephalopathy (HP:0006965)1.77250254
78Tubulointerstitial fibrosis (HP:0005576)1.76600669
79Microglossia (HP:0000171)1.76007615
80Pancreatic fibrosis (HP:0100732)1.75554947
81Vitreoretinal degeneration (HP:0000655)1.74145068
82Exertional dyspnea (HP:0002875)1.73634840
83Neonatal respiratory distress (HP:0002643)1.70282778
84Aplasia/hypoplasia of the uterus (HP:0008684)1.69513611
85Short femoral neck (HP:0100864)1.69289049
86Poor speech (HP:0002465)1.68302405
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.68109058
88Type 2 muscle fiber atrophy (HP:0003554)1.68086323
89Ulnar deviation of the wrist (HP:0003049)1.67272258
90Sensorimotor neuropathy (HP:0007141)1.67148132
91Palmoplantar hyperkeratosis (HP:0000972)1.65916114
92Dyschromatopsia (HP:0007641)1.65477902
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65114451
94Abnormality of serine family amino acid metabolism (HP:0010894)1.63107676
95Abnormality of glycine metabolism (HP:0010895)1.63107676
96Abnormality of the line of Schwalbe (HP:0008048)1.63066492
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62455990
98Hypoplasia of the brainstem (HP:0002365)1.62455990
99Posterior embryotoxon (HP:0000627)1.58509181
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58135848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK16.75608415
2TSSK64.05258112
3ACVR1B2.97801578
4EIF2AK32.89075485
5EIF2AK12.79905846
6NLK2.76004678
7BUB12.66480891
8TESK12.57499823
9PLK22.37161874
10MAP4K12.06987960
11TRIM281.95814075
12BMPR1B1.87570908
13PLK31.75943041
14NUAK11.73931453
15MUSK1.66087647
16ZAK1.65633000
17TGFBR11.55664864
18PBK1.46693007
19SGK21.43684517
20CSNK1G11.35069261
21WEE11.34190886
22ADRBK21.33372808
23PLK41.31593046
24TIE11.29744582
25AKT31.28891777
26NEK11.26005813
27MAP4K21.22889913
28MKNK21.22303765
29TXK1.20265845
30MINK11.16823497
31PASK1.12218004
32PRKCG1.11463977
33MYLK1.10562927
34SRPK11.08660507
35ERBB41.03941003
36WNK31.01632909
37FRK1.00638095
38PLK11.00463400
39BCKDK0.96622201
40GRK70.93322798
41PKN10.91017606
42MST40.89566037
43CDC70.88506937
44PAK10.84582763
45GRK10.83835895
46EIF2AK20.81280486
47MKNK10.80213812
48MAP3K40.79560761
49SGK2230.79398195
50SGK4940.79398195
51STK390.78707997
52CSNK2A20.77532470
53VRK10.77256495
54DYRK1A0.74150550
55CSF1R0.72148701
56TLK10.70743090
57MAP2K70.70298808
58ADRBK10.69428343
59TTK0.69347365
60SGK30.69185268
61RPS6KA50.66546689
62LMTK20.65856391
63CSNK2A10.64710104
64WNK40.64658730
65PRKCQ0.64504718
66INSRR0.64170661
67FLT30.62023451
68ROCK20.58954598
69ERBB30.56157448
70CSNK1A10.51839605
71BCR0.51705898
72TGFBR20.51616353
73IKBKE0.48997324
74OBSCN0.48873661
75GRK50.48768214
76CDK40.45926550
77STK100.43557896
78MOS0.41967294
79STK160.41234184
80IGF1R0.41044778
81SCYL20.39255220
82MAP3K120.39236158
83VRK20.39117965
84PAK20.37588767
85PRKCA0.36366873
86CDC42BPA0.36185220
87GSK3A0.35089236
88AURKA0.34858315
89PRKG10.34100721
90ROCK10.33426285
91CHEK20.32122853
92EGFR0.31947850
93ATM0.31570294
94EPHA40.31142329
95PRKCB0.30830941
96AURKB0.30828684
97BRD40.29946748
98CDK80.29944059
99LCK0.29934396
100MAPK90.29425733

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041227.58253569
2Pentose phosphate pathway_Homo sapiens_hsa000304.68391070
3Drug metabolism - other enzymes_Homo sapiens_hsa009833.86267773
4Ribosome_Homo sapiens_hsa030103.33568468
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.11860023
6DNA replication_Homo sapiens_hsa030302.79868129
7Proteasome_Homo sapiens_hsa030502.73023926
8Pyrimidine metabolism_Homo sapiens_hsa002402.57153487
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20561465
10Non-homologous end-joining_Homo sapiens_hsa034502.13817181
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70575210
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66159507
13Carbon metabolism_Homo sapiens_hsa012001.54060698
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.52931542
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49447762
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44747667
17Measles_Homo sapiens_hsa051621.44571277
18Butanoate metabolism_Homo sapiens_hsa006501.43098336
19Fat digestion and absorption_Homo sapiens_hsa049751.42504457
20Hematopoietic cell lineage_Homo sapiens_hsa046401.40947853
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33567743
22Mismatch repair_Homo sapiens_hsa034301.32126548
23One carbon pool by folate_Homo sapiens_hsa006701.28787788
24Sulfur metabolism_Homo sapiens_hsa009201.22660955
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21875265
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18655531
27RNA transport_Homo sapiens_hsa030131.16898943
28RNA degradation_Homo sapiens_hsa030181.13992669
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10211819
30Purine metabolism_Homo sapiens_hsa002301.08065599
31Caffeine metabolism_Homo sapiens_hsa002321.03706560
32Steroid biosynthesis_Homo sapiens_hsa001001.01779105
33Protein export_Homo sapiens_hsa030600.99643348
34Homologous recombination_Homo sapiens_hsa034400.94052542
35Glycerolipid metabolism_Homo sapiens_hsa005610.93605797
36Thyroid cancer_Homo sapiens_hsa052160.93268805
37Propanoate metabolism_Homo sapiens_hsa006400.91920526
38Primary immunodeficiency_Homo sapiens_hsa053400.91302189
39Fanconi anemia pathway_Homo sapiens_hsa034600.84760321
40RNA polymerase_Homo sapiens_hsa030200.84507193
41Systemic lupus erythematosus_Homo sapiens_hsa053220.83326450
42Apoptosis_Homo sapiens_hsa042100.82300554
43Cell cycle_Homo sapiens_hsa041100.81364787
44Tryptophan metabolism_Homo sapiens_hsa003800.76973286
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73109636
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72367504
47Fatty acid elongation_Homo sapiens_hsa000620.70506285
48Taste transduction_Homo sapiens_hsa047420.69697800
49Phototransduction_Homo sapiens_hsa047440.67968189
50Nicotine addiction_Homo sapiens_hsa050330.67385869
51Vitamin B6 metabolism_Homo sapiens_hsa007500.66598262
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65495890
53Metabolic pathways_Homo sapiens_hsa011000.65440789
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64589395
55Legionellosis_Homo sapiens_hsa051340.63114277
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58300342
57Peroxisome_Homo sapiens_hsa041460.58156455
58Oxidative phosphorylation_Homo sapiens_hsa001900.55975039
59Glutathione metabolism_Homo sapiens_hsa004800.54656253
60p53 signaling pathway_Homo sapiens_hsa041150.53397152
61Parkinsons disease_Homo sapiens_hsa050120.53348898
62mRNA surveillance pathway_Homo sapiens_hsa030150.48426356
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48323343
64Alcoholism_Homo sapiens_hsa050340.47864256
65Folate biosynthesis_Homo sapiens_hsa007900.45797915
66Olfactory transduction_Homo sapiens_hsa047400.45503723
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.44865697
68Gastric acid secretion_Homo sapiens_hsa049710.44713828
69Alzheimers disease_Homo sapiens_hsa050100.44651851
70beta-Alanine metabolism_Homo sapiens_hsa004100.44156610
71Spliceosome_Homo sapiens_hsa030400.41961750
72Biosynthesis of amino acids_Homo sapiens_hsa012300.41831938
73Protein digestion and absorption_Homo sapiens_hsa049740.40630191
74Cardiac muscle contraction_Homo sapiens_hsa042600.38786710
75Huntingtons disease_Homo sapiens_hsa050160.37203368
76Retinol metabolism_Homo sapiens_hsa008300.36993139
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35788480
78Nitrogen metabolism_Homo sapiens_hsa009100.33141230
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32357262
80Chemical carcinogenesis_Homo sapiens_hsa052040.32249503
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31359486
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31257557
83Hippo signaling pathway_Homo sapiens_hsa043900.31241654
84Base excision repair_Homo sapiens_hsa034100.30151962
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.29174749
86Tight junction_Homo sapiens_hsa045300.27859556
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26367459
88Oocyte meiosis_Homo sapiens_hsa041140.25317459
89Basal transcription factors_Homo sapiens_hsa030220.24055334
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23771677
91Influenza A_Homo sapiens_hsa051640.20867982
92Pyruvate metabolism_Homo sapiens_hsa006200.19394408
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16108280
94Salivary secretion_Homo sapiens_hsa049700.15687852
95Nucleotide excision repair_Homo sapiens_hsa034200.15432214
96Mineral absorption_Homo sapiens_hsa049780.14619183
97Selenocompound metabolism_Homo sapiens_hsa004500.14203785
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13538763
99TGF-beta signaling pathway_Homo sapiens_hsa043500.13114709
100Ether lipid metabolism_Homo sapiens_hsa005650.10741616

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