IQCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.93597645
2epithelial cilium movement (GO:0003351)9.39298983
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.16858884
4motile cilium assembly (GO:0044458)8.94835972
5axoneme assembly (GO:0035082)6.09045729
6regulation of cilium movement (GO:0003352)5.72709618
7sperm motility (GO:0030317)5.59256758
8sperm capacitation (GO:0048240)5.27271693
9centriole replication (GO:0007099)5.19138859
10centriole assembly (GO:0098534)5.18028029
11ventricular system development (GO:0021591)4.83911648
12negative regulation of inclusion body assembly (GO:0090084)4.83812608
13microtubule polymerization or depolymerization (GO:0031109)4.74557261
14left/right pattern formation (GO:0060972)4.69616602
15left/right axis specification (GO:0070986)4.44269326
16microtubule depolymerization (GO:0007019)4.41887829
17cilium organization (GO:0044782)4.40790906
18intraciliary transport (GO:0042073)4.39834188
19spermatid development (GO:0007286)4.37990357
20cilium assembly (GO:0042384)4.30985390
21regulation of microtubule-based movement (GO:0060632)4.23190282
22retinal cone cell development (GO:0046549)4.13704610
23microtubule bundle formation (GO:0001578)4.11098942
24multicellular organism reproduction (GO:0032504)4.04706896
25protein polyglutamylation (GO:0018095)3.92761678
26single strand break repair (GO:0000012)3.91702479
27acrosome reaction (GO:0007340)3.88071671
28central nervous system myelination (GO:0022010)3.68597226
29axon ensheathment in central nervous system (GO:0032291)3.68597226
30microtubule severing (GO:0051013)3.61189617
31microtubule-based movement (GO:0007018)3.52211645
32cellular component assembly involved in morphogenesis (GO:0010927)3.46531348
33sperm-egg recognition (GO:0035036)3.43181170
34regulation of inclusion body assembly (GO:0090083)3.33927626
35cilium morphogenesis (GO:0060271)3.32976030
36binding of sperm to zona pellucida (GO:0007339)3.32231004
37reproduction (GO:0000003)3.25794696
38regulation of meiosis I (GO:0060631)3.22961485
39regulation of female gonad development (GO:2000194)3.21880248
40fusion of sperm to egg plasma membrane (GO:0007342)3.17422662
41piRNA metabolic process (GO:0034587)3.16534578
42single fertilization (GO:0007338)3.13955392
43calcium ion-dependent exocytosis (GO:0017156)3.11029014
44cochlea development (GO:0090102)3.07611154
45meiotic cell cycle (GO:0051321)3.04277762
46spermatogenesis (GO:0007283)3.03070835
47primary alcohol catabolic process (GO:0034310)3.02214691
48cell projection assembly (GO:0030031)3.02114467
49male gamete generation (GO:0048232)3.01821978
50fertilization (GO:0009566)2.92307202
51protein localization to cilium (GO:0061512)2.91084061
52gamete generation (GO:0007276)2.90854027
53germ cell development (GO:0007281)2.87541494
54lateral sprouting from an epithelium (GO:0060601)2.87282238
55sleep (GO:0030431)2.82426608
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82251088
57establishment of tissue polarity (GO:0007164)2.79289790
58establishment of planar polarity (GO:0001736)2.79289790
59DNA methylation involved in gamete generation (GO:0043046)2.78794030
60cell-cell recognition (GO:0009988)2.76891927
61phosphatidylethanolamine biosynthetic process (GO:0006646)2.76159790
62one-carbon compound transport (GO:0019755)2.72926038
63smoothened signaling pathway (GO:0007224)2.69763454
64chromosome condensation (GO:0030261)2.69100583
65acrosome assembly (GO:0001675)2.64038159
66glomerular epithelial cell development (GO:0072310)2.63174853
67DNA packaging (GO:0006323)2.62699923
68L-amino acid import (GO:0043092)2.60821452
69notochord development (GO:0030903)2.58798065
70cellular process involved in reproduction in multicellular organism (GO:0022412)2.56315665
71histone exchange (GO:0043486)2.56206389
72spermatid nucleus differentiation (GO:0007289)2.54441095
73male meiosis (GO:0007140)2.54370063
74regulation of DNA methylation (GO:0044030)2.52209877
75determination of left/right symmetry (GO:0007368)2.51950458
76establishment of apical/basal cell polarity (GO:0035089)2.51945465
77phosphatidylethanolamine metabolic process (GO:0046337)2.50102497
78relaxation of smooth muscle (GO:0044557)2.46423199
79plasma membrane fusion (GO:0045026)2.46340692
80vitamin transmembrane transport (GO:0035461)2.45001444
81cerebral cortex neuron differentiation (GO:0021895)2.44526310
82limb development (GO:0060173)2.42463010
83appendage development (GO:0048736)2.42463010
84female gamete generation (GO:0007292)2.40730485
85retinal rod cell development (GO:0046548)2.38923590
86cytoplasmic microtubule organization (GO:0031122)2.38861542
87determination of bilateral symmetry (GO:0009855)2.37210781
88male meiosis I (GO:0007141)2.35256775
89apical protein localization (GO:0045176)2.35187205
90lung epithelium development (GO:0060428)2.34624530
91retina layer formation (GO:0010842)2.33974422
92negative regulation of astrocyte differentiation (GO:0048712)2.33763987
93protein refolding (GO:0042026)2.33087410
94specification of symmetry (GO:0009799)2.32386289
95regulation of mesoderm development (GO:2000380)2.32230499
96microtubule-based process (GO:0007017)2.31654187
97hyperosmotic salinity response (GO:0042538)2.30172552
98metanephric mesenchyme development (GO:0072075)2.29220386
99axonemal dynein complex assembly (GO:0070286)12.5880889
100cilium or flagellum-dependent cell motility (GO:0001539)10.7122718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.24686966
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72061342
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75711586
4GBX2_23144817_ChIP-Seq_PC3_Human2.67893803
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.36672402
6FUS_26573619_Chip-Seq_HEK293_Human2.26072829
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22203338
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21989998
9DROSHA_22980978_ChIP-Seq_HELA_Human2.17968876
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13076907
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10999233
12TOP2B_26459242_ChIP-Seq_MCF-7_Human1.82742289
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82549292
14TAF15_26573619_Chip-Seq_HEK293_Human1.80244038
15P300_19829295_ChIP-Seq_ESCs_Human1.79339299
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.75337998
17* SMAD3_21741376_ChIP-Seq_EPCs_Human1.75103012
18SMAD4_21799915_ChIP-Seq_A2780_Human1.73427417
19* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73302384
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71783671
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70942063
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70942063
23VDR_22108803_ChIP-Seq_LS180_Human1.61150538
24CBP_20019798_ChIP-Seq_JUKART_Human1.60761265
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60761265
26AR_21572438_ChIP-Seq_LNCaP_Human1.58959651
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56151937
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55497392
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.54057681
30CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51775745
31REST_21632747_ChIP-Seq_MESCs_Mouse1.49967780
32* SMAD4_21741376_ChIP-Seq_EPCs_Human1.49778209
33TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47997026
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.44051534
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42918154
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42560162
37* AR_25329375_ChIP-Seq_VCAP_Human1.40428761
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40202938
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.39634822
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39386246
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37054215
42RUNX2_22187159_ChIP-Seq_PCA_Human1.36432042
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33142786
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32074949
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.30699655
46SMAD3_21741376_ChIP-Seq_ESCs_Human1.29452173
47* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29061062
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.28994925
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28919946
50STAT3_23295773_ChIP-Seq_U87_Human1.28776533
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27037744
52SMAD4_21741376_ChIP-Seq_HESCs_Human1.25136750
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24598409
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23325898
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22488310
56* TCF4_23295773_ChIP-Seq_U87_Human1.20764597
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.20520732
58TP53_18474530_ChIP-ChIP_U2OS_Human1.20008108
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19235473
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19067533
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18529915
62TCF4_22108803_ChIP-Seq_LS180_Human1.18248364
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16532078
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15759003
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15332435
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15332435
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15051818
68AHR_22903824_ChIP-Seq_MCF-7_Human1.14904284
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.14699457
70TBL1_22424771_ChIP-Seq_293T_Human1.14332470
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13603812
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.13343402
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12391833
74RNF2_27304074_Chip-Seq_NSC_Mouse1.10092751
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09750666
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09532314
77ER_23166858_ChIP-Seq_MCF-7_Human1.08922030
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08781790
79EWS_26573619_Chip-Seq_HEK293_Human1.08528473
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.08128638
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.07820164
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07669439
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06959746
84ETV1_20927104_ChIP-Seq_GIST48_Human1.05596598
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.04803884
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04115339
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02915004
88NFYB_21822215_ChIP-Seq_K562_Human1.00728455
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99748485
90PHF8_20622853_ChIP-Seq_HELA_Human0.99573640
91SOX2_19829295_ChIP-Seq_ESCs_Human0.98795439
92NANOG_19829295_ChIP-Seq_ESCs_Human0.98795439
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98528694
94BCAT_22108803_ChIP-Seq_LS180_Human0.98266306
95CBP_21632823_ChIP-Seq_H3396_Human0.97920165
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.97042571
97TP63_23658742_ChIP-Seq_EP156T_Human0.96073806
98RBPJ_21746931_ChIP-Seq_IB4_Human0.95292310
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95101492
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93590178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.77332750
2MP0002653_abnormal_ependyma_morphology3.30339151
3MP0005377_hearing/vestibular/ear_phenot3.20471639
4MP0003878_abnormal_ear_physiology3.20471639
5MP0001984_abnormal_olfaction3.04655746
6MP0003136_yellow_coat_color2.74492219
7MP0003718_maternal_effect2.64984708
8MP0008877_abnormal_DNA_methylation2.64489116
9MP0003890_abnormal_embryonic-extraembry2.53441941
10MP0000566_synostosis2.39986983
11MP0008789_abnormal_olfactory_epithelium2.31873644
12MP0001485_abnormal_pinna_reflex2.19252557
13MP0001929_abnormal_gametogenesis2.08846089
14MP0006292_abnormal_olfactory_placode2.04724524
15MP0005499_abnormal_olfactory_system2.03814337
16MP0005394_taste/olfaction_phenotype2.03814337
17MP0003698_abnormal_male_reproductive2.02144470
18MP0002272_abnormal_nervous_system1.99005193
19MP0010030_abnormal_orbit_morphology1.94109778
20MP0003880_abnormal_central_pattern1.94068147
21MP0004133_heterotaxia1.94060151
22MP0004885_abnormal_endolymph1.86997868
23MP0004859_abnormal_synaptic_plasticity1.84854151
24MP0001486_abnormal_startle_reflex1.82555193
25MP0008875_abnormal_xenobiotic_pharmacok1.81160750
26MP0002734_abnormal_mechanical_nocicepti1.74747539
27MP0009745_abnormal_behavioral_response1.67457844
28MP0002735_abnormal_chemical_nociception1.58013968
29MP0003635_abnormal_synaptic_transmissio1.56648156
30MP0002132_abnormal_respiratory_system1.52928539
31MP0009379_abnormal_foot_pigmentation1.52274687
32MP0009046_muscle_twitch1.51967484
33MP0002160_abnormal_reproductive_system1.48017381
34MP0001293_anophthalmia1.46142579
35MP0002282_abnormal_trachea_morphology1.44973228
36MP0003879_abnormal_hair_cell1.42821287
37MP0002277_abnormal_respiratory_mucosa1.40485307
38MP0001968_abnormal_touch/_nociception1.40187851
39MP0002161_abnormal_fertility/fecundity1.38739512
40MP0002064_seizures1.38398070
41MP0001963_abnormal_hearing_physiology1.38396295
42MP0002210_abnormal_sex_determination1.38312162
43MP0002572_abnormal_emotion/affect_behav1.37569661
44MP0009780_abnormal_chondrocyte_physiolo1.36212997
45MP0000579_abnormal_nail_morphology1.35599214
46MP0004043_abnormal_pH_regulation1.35578385
47MP0000049_abnormal_middle_ear1.34086296
48MP0005551_abnormal_eye_electrophysiolog1.33512017
49MP0002233_abnormal_nose_morphology1.30903416
50MP0000762_abnormal_tongue_morphology1.30124058
51MP0000026_abnormal_inner_ear1.26483298
52MP0003119_abnormal_digestive_system1.24001032
53MP0002234_abnormal_pharynx_morphology1.22968577
54MP0001299_abnormal_eye_distance/1.21876815
55MP0002249_abnormal_larynx_morphology1.20965691
56MP0004270_analgesia1.14118644
57MP0005395_other_phenotype1.12117320
58MP0002638_abnormal_pupillary_reflex1.11511131
59MP0005423_abnormal_somatic_nervous1.11078838
60MP0002063_abnormal_learning/memory/cond1.10904564
61MP0000653_abnormal_sex_gland1.10358416
62MP0005623_abnormal_meninges_morphology1.08722371
63MP0005646_abnormal_pituitary_gland1.06456287
64MP0001145_abnormal_male_reproductive1.05448266
65MP0002557_abnormal_social/conspecific_i1.04848933
66MP0002736_abnormal_nociception_after1.03938796
67MP0002067_abnormal_sensory_capabilities1.03240499
68MP0000631_abnormal_neuroendocrine_gland1.02771608
69MP0000955_abnormal_spinal_cord1.01598115
70MP0003941_abnormal_skin_development0.99817940
71MP0000778_abnormal_nervous_system0.96628613
72MP0001970_abnormal_pain_threshold0.96626967
73MP0004742_abnormal_vestibular_system0.94240050
74MP0004019_abnormal_vitamin_homeostasis0.90769554
75MP0003937_abnormal_limbs/digits/tail_de0.90646574
76MP0001905_abnormal_dopamine_level0.90589947
77MP0010386_abnormal_urinary_bladder0.90443061
78MP0001502_abnormal_circadian_rhythm0.88824347
79MP0000678_abnormal_parathyroid_gland0.87363090
80MP0008569_lethality_at_weaning0.87246912
81MP0004142_abnormal_muscle_tone0.85667001
82MP0005253_abnormal_eye_physiology0.84963369
83MP0000383_abnormal_hair_follicle0.84319585
84MP0002882_abnormal_neuron_morphology0.83506022
85MP0002752_abnormal_somatic_nervous0.83283252
86MP0002229_neurodegeneration0.82261907
87MP0006276_abnormal_autonomic_nervous0.81995066
88MP0003861_abnormal_nervous_system0.81195101
89MP0002733_abnormal_thermal_nociception0.79069162
90MP0002928_abnormal_bile_duct0.78052665
91MP0010368_abnormal_lymphatic_system0.77812047
92MP0002139_abnormal_hepatobiliary_system0.77244436
93MP0001501_abnormal_sleep_pattern0.77225144
94MP0002152_abnormal_brain_morphology0.73340384
95MP0005389_reproductive_system_phenotype0.72699763
96MP0002084_abnormal_developmental_patter0.72366100
97MP0001188_hyperpigmentation0.72349074
98MP0006072_abnormal_retinal_apoptosis0.69777970
99MP0003938_abnormal_ear_development0.68948758
100MP0001286_abnormal_eye_development0.68481581

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.78365663
2Abnormal respiratory motile cilium physiology (HP:0012261)8.98398023
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.83464764
4Absent/shortened dynein arms (HP:0200106)8.83464764
5Abnormal ciliary motility (HP:0012262)8.80888509
6Abnormal respiratory motile cilium morphology (HP:0005938)8.59871984
7Abnormal respiratory epithelium morphology (HP:0012253)8.59871984
8Rhinitis (HP:0012384)7.78865212
9Chronic bronchitis (HP:0004469)6.00103465
10Bronchiectasis (HP:0002110)5.27813097
11Infertility (HP:0000789)4.55586610
12Nasal polyposis (HP:0100582)4.34727283
13Male infertility (HP:0003251)4.27004613
14Chronic hepatic failure (HP:0100626)3.99971267
15Pancreatic fibrosis (HP:0100732)3.69184935
16Tubulointerstitial nephritis (HP:0001970)3.53453698
17True hermaphroditism (HP:0010459)3.50036846
18Abnormality of the nasal mucosa (HP:0000433)3.44789795
19Occipital encephalocele (HP:0002085)3.29438718
20Nephronophthisis (HP:0000090)3.13113870
21Molar tooth sign on MRI (HP:0002419)3.00274555
22Abnormality of midbrain morphology (HP:0002418)3.00274555
23Chronic sinusitis (HP:0011109)2.79965192
24Pancreatic cysts (HP:0001737)2.75556347
25Bronchitis (HP:0012387)2.68330712
26Cystic liver disease (HP:0006706)2.64932097
27Abnormality of the renal medulla (HP:0100957)2.58971910
28Myokymia (HP:0002411)2.51955688
29Median cleft lip (HP:0000161)2.46496274
30Supernumerary spleens (HP:0009799)2.39291533
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.37772380
32Recurrent sinusitis (HP:0011108)2.36027719
33Medial flaring of the eyebrow (HP:0010747)2.30105154
34Recurrent otitis media (HP:0000403)2.29516567
35Postaxial foot polydactyly (HP:0001830)2.27311750
36Anencephaly (HP:0002323)2.25001472
37Bell-shaped thorax (HP:0001591)2.19088268
38Male pseudohermaphroditism (HP:0000037)2.14522636
39Congenital hepatic fibrosis (HP:0002612)2.06832600
40Progressive cerebellar ataxia (HP:0002073)2.04323230
41Septo-optic dysplasia (HP:0100842)2.04133274
42Sclerocornea (HP:0000647)2.03710172
43Gait imbalance (HP:0002141)2.01447250
44Tubular atrophy (HP:0000092)1.99724528
45Genital tract atresia (HP:0001827)1.99131373
46Tubulointerstitial abnormality (HP:0001969)1.97502827
47Atonic seizures (HP:0010819)1.96552527
48Congenital primary aphakia (HP:0007707)1.96156534
49Nephrogenic diabetes insipidus (HP:0009806)1.89336860
50Abnormal drinking behavior (HP:0030082)1.86036504
51Polydipsia (HP:0001959)1.86036504
52Vaginal atresia (HP:0000148)1.85754091
53Postaxial hand polydactyly (HP:0001162)1.84577079
54Anophthalmia (HP:0000528)1.83126149
55Hyperkalemia (HP:0002153)1.80090447
56Abnormality of the labia minora (HP:0012880)1.79258762
57Atelectasis (HP:0100750)1.78004600
58Action tremor (HP:0002345)1.72747912
59Hyperactive renin-angiotensin system (HP:0000841)1.70991162
60Maternal diabetes (HP:0009800)1.69361622
61Focal motor seizures (HP:0011153)1.68931020
62Preaxial hand polydactyly (HP:0001177)1.67029222
63Abnormality of macular pigmentation (HP:0008002)1.66553251
64Osteomalacia (HP:0002749)1.65595419
65Oculomotor apraxia (HP:0000657)1.64437929
66Stage 5 chronic kidney disease (HP:0003774)1.63850851
67Poor coordination (HP:0002370)1.59904938
68Abdominal situs inversus (HP:0003363)1.58797813
69Abnormality of abdominal situs (HP:0011620)1.58797813
70Abnormality of permanent molar morphology (HP:0011071)1.58480669
71Abnormality of the dental root (HP:0006486)1.58480669
72Taurodontia (HP:0000679)1.58480669
73Chronic otitis media (HP:0000389)1.57196658
74Oligodactyly (hands) (HP:0001180)1.55218093
75Esophageal atresia (HP:0002032)1.54876537
76Renal dysplasia (HP:0000110)1.53853759
77Optic nerve hypoplasia (HP:0000609)1.52033525
78Abnormality of the dental pulp (HP:0006479)1.50339897
79Gastrointestinal atresia (HP:0002589)1.49643698
80Severe visual impairment (HP:0001141)1.49594403
81Abnormality of the middle phalanges of the toes (HP:0010183)1.49464635
82Cone-rod dystrophy (HP:0000548)1.47189147
83Absent septum pellucidum (HP:0001331)1.47181406
84Abnormality of molar (HP:0011077)1.46075127
85Abnormality of molar morphology (HP:0011070)1.46075127
86Abnormal biliary tract physiology (HP:0012439)1.44724518
87Bile duct proliferation (HP:0001408)1.44724518
88Impulsivity (HP:0100710)1.41130215
89Bifid scrotum (HP:0000048)1.40640645
90Lip pit (HP:0100267)1.39935046
91Hyperaldosteronism (HP:0000859)1.39624740
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.38418149
93Labial hypoplasia (HP:0000066)1.38122306
94Polyuria (HP:0000103)1.36596134
95Furrowed tongue (HP:0000221)1.36074820
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.35979188
97Hypoplastic labia majora (HP:0000059)1.35355438
98Bony spicule pigmentary retinopathy (HP:0007737)1.35296760
99Recurrent corneal erosions (HP:0000495)1.34937922
100Partial duplication of thumb phalanx (HP:0009944)1.33600955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.94928797
2PNCK4.57667606
3PLK43.05066141
4MAP3K92.54254620
5MST42.37828396
6EPHA42.17748944
7TSSK62.14585852
8NEK62.06524830
9STK38L1.88938286
10TTK1.83348839
11ARAF1.79638188
12PLK21.73021163
13PRKD31.60162103
14PINK11.49959628
15MAP4K21.44005830
16STK381.41611730
17EIF2AK31.41032159
18TNIK1.40156037
19BMPR1B1.38089746
20NTRK31.36635861
21STK391.35414941
22MAPKAPK51.26231260
23WEE11.22994424
24CASK1.20734908
25CDK191.20302693
26MAP3K121.19667078
27MAP3K41.18728109
28CDC71.13276175
29INSRR1.13065727
30NTRK21.07347138
31VRK11.07330581
32MET1.05264044
33STK241.05138855
34PBK1.02279308
35LATS20.99761677
36EPHA20.98742345
37PRKCG0.98198159
38PTK2B0.97348791
39MKNK10.92640249
40TIE10.90838136
41OXSR10.89245828
42AURKA0.87430943
43PLK10.86481549
44PLK30.86290592
45BRAF0.85409900
46DMPK0.83900320
47TGFBR10.83390511
48LATS10.83239923
49MAP3K20.83010700
50ACVR1B0.81848723
51TYRO30.80455801
52ZAK0.79716393
53CAMK1G0.79621733
54CAMK2A0.77651307
55MUSK0.75185101
56UHMK10.73904864
57WNK30.73682803
58TESK10.73436240
59NLK0.68935994
60CDK30.68602834
61MAPKAPK30.67277125
62WNK40.66829404
63SGK2230.66199952
64SGK4940.66199952
65PRKCI0.63896147
66PRKG10.63705854
67TLK10.62530063
68MAP2K70.60681220
69CAMK10.60080505
70PRKCQ0.59239293
71WNK10.58817358
72SGK10.57416512
73MINK10.55003825
74MAPK130.54825182
75LMTK20.53021067
76NME10.52911567
77ROCK10.51700875
78MAP3K130.51261232
79DYRK1A0.50256705
80BRSK20.48945770
81CSNK1E0.46924970
82CDK50.46380307
83PRKCE0.46365995
84MKNK20.45740119
85PRKCZ0.43651580
86MST1R0.43394421
87BRSK10.41291467
88GRK50.40689866
89DDR20.39996198
90KSR20.38616827
91FGFR20.38020541
92ADRBK20.37748347
93CAMK2G0.37431155
94PRKACA0.37125577
95PAK60.35707093
96NTRK10.33640383
97CSNK1G10.33316586
98SGK20.32520747
99BRD40.32216320
100RPS6KA30.31339650

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09892982
2Olfactory transduction_Homo sapiens_hsa047402.41817682
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.37460066
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33297556
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.29074678
6Histidine metabolism_Homo sapiens_hsa003402.19958890
7Huntingtons disease_Homo sapiens_hsa050162.15673875
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07710399
9Chemical carcinogenesis_Homo sapiens_hsa052042.02501062
10Taste transduction_Homo sapiens_hsa047421.90193064
11Phenylalanine metabolism_Homo sapiens_hsa003601.83461946
12Basal transcription factors_Homo sapiens_hsa030221.81702164
13beta-Alanine metabolism_Homo sapiens_hsa004101.76195236
14Phototransduction_Homo sapiens_hsa047441.67450222
15Salivary secretion_Homo sapiens_hsa049701.62070146
16Circadian entrainment_Homo sapiens_hsa047131.60430037
17Fatty acid biosynthesis_Homo sapiens_hsa000611.60112246
18GABAergic synapse_Homo sapiens_hsa047271.57553024
19Tyrosine metabolism_Homo sapiens_hsa003501.53873951
20Morphine addiction_Homo sapiens_hsa050321.51066082
21Glutamatergic synapse_Homo sapiens_hsa047241.46830320
22Synaptic vesicle cycle_Homo sapiens_hsa047211.42349093
23Cardiac muscle contraction_Homo sapiens_hsa042601.38696568
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38136993
25Tight junction_Homo sapiens_hsa045301.37854426
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37733206
27Amphetamine addiction_Homo sapiens_hsa050311.35798666
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34979804
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34329388
30Oocyte meiosis_Homo sapiens_hsa041141.30594360
31Insulin secretion_Homo sapiens_hsa049111.28535650
32Gastric acid secretion_Homo sapiens_hsa049711.27161043
33Glutathione metabolism_Homo sapiens_hsa004801.24484517
34Fatty acid degradation_Homo sapiens_hsa000711.18514324
35Butanoate metabolism_Homo sapiens_hsa006501.18472885
36Retinol metabolism_Homo sapiens_hsa008301.18032620
37Calcium signaling pathway_Homo sapiens_hsa040201.16030587
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14687789
39Serotonergic synapse_Homo sapiens_hsa047261.14263041
40cAMP signaling pathway_Homo sapiens_hsa040241.11515324
41Circadian rhythm_Homo sapiens_hsa047101.10431153
42Linoleic acid metabolism_Homo sapiens_hsa005911.09488996
43Hedgehog signaling pathway_Homo sapiens_hsa043401.07052114
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05525543
45Caffeine metabolism_Homo sapiens_hsa002321.04499838
46Wnt signaling pathway_Homo sapiens_hsa043101.03580906
47Hippo signaling pathway_Homo sapiens_hsa043900.99225048
48Propanoate metabolism_Homo sapiens_hsa006400.97016348
49Cocaine addiction_Homo sapiens_hsa050300.96582595
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.92918441
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89416819
52Gap junction_Homo sapiens_hsa045400.88460207
53TGF-beta signaling pathway_Homo sapiens_hsa043500.87587894
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85930186
55Oxidative phosphorylation_Homo sapiens_hsa001900.85608473
56Bile secretion_Homo sapiens_hsa049760.85403307
57Long-term potentiation_Homo sapiens_hsa047200.85393967
58Dopaminergic synapse_Homo sapiens_hsa047280.83989892
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83536994
60Basal cell carcinoma_Homo sapiens_hsa052170.82982806
61Fanconi anemia pathway_Homo sapiens_hsa034600.82110634
62Ovarian steroidogenesis_Homo sapiens_hsa049130.81470931
63Oxytocin signaling pathway_Homo sapiens_hsa049210.81034750
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79973983
65Adherens junction_Homo sapiens_hsa045200.79357038
66RNA degradation_Homo sapiens_hsa030180.76649856
67ABC transporters_Homo sapiens_hsa020100.76425731
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75023988
69Parkinsons disease_Homo sapiens_hsa050120.73855311
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.71474028
71Arginine and proline metabolism_Homo sapiens_hsa003300.71467727
72Long-term depression_Homo sapiens_hsa047300.70490198
73Protein digestion and absorption_Homo sapiens_hsa049740.69768659
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69750531
75Pancreatic secretion_Homo sapiens_hsa049720.68341239
76Mismatch repair_Homo sapiens_hsa034300.68320320
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67732947
78Dorso-ventral axis formation_Homo sapiens_hsa043200.67322426
79ECM-receptor interaction_Homo sapiens_hsa045120.66934042
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65827148
81RNA transport_Homo sapiens_hsa030130.64521066
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.64022690
83Cell cycle_Homo sapiens_hsa041100.62898331
84Alzheimers disease_Homo sapiens_hsa050100.62396817
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60534759
86Nucleotide excision repair_Homo sapiens_hsa034200.60465747
87Melanogenesis_Homo sapiens_hsa049160.60416502
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59802165
89Nitrogen metabolism_Homo sapiens_hsa009100.59411219
90Ribosome_Homo sapiens_hsa030100.57170900
91Cholinergic synapse_Homo sapiens_hsa047250.56666992
92Axon guidance_Homo sapiens_hsa043600.54925936
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54269804
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.53908035
95Renin secretion_Homo sapiens_hsa049240.52270479
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51493768
97Peroxisome_Homo sapiens_hsa041460.49176980
98Base excision repair_Homo sapiens_hsa034100.49106438
99Pyruvate metabolism_Homo sapiens_hsa006200.47746863
100Thyroid hormone synthesis_Homo sapiens_hsa049180.47485441

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