ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.30635723
2	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	8.83693991
3	sperm motility (GO:0030317)	8.83001248
4	positive regulation of catecholamine secretion (GO:0033605)	8.66830629
5	regulation of phosphoprotein phosphatase activity (GO:0043666)	7.68866326
6	multicellular organism reproduction (GO:0032504)	7.45912359
7	organic cation transport (GO:0015695)	7.44018084
8	male meiosis (GO:0007140)	7.15407885
9	spermatid development (GO:0007286)	6.78609913
10	regulation of oxidative stress-induced neuron death (GO:1903203)	6.40363668
11	binding of sperm to zona pellucida (GO:0007339)	6.19939677
12	motile cilium assembly (GO:0044458)	6.16919367
13	cilium or flagellum-dependent cell motility (GO:0001539)	6.10966256
14	fusion of sperm to egg plasma membrane (GO:0007342)	6.03255935
15	sperm-egg recognition (GO:0035036)	5.83756133
16	ventricular system development (GO:0021591)	5.35355971
17	axonemal dynein complex assembly (GO:0070286)	5.25163392
18	reproduction (GO:0000003)	5.21772999
19	single fertilization (GO:0007338)	5.20616432
20	cell-cell recognition (GO:0009988)	5.18981743
21	potassium ion export (GO:0071435)	5.11013473
22	protein-DNA complex disassembly (GO:0032986)	5.06595603
23	nucleosome disassembly (GO:0006337)	5.06595603
24	regulation of oxidative phosphorylation (GO:0002082)	4.80232522
25	regulation of dopamine secretion (GO:0014059)	4.64812781
26	plasma membrane fusion (GO:0045026)	4.62346088
27	relaxation of smooth muscle (GO:0044557)	4.60063085
28	regulation of synaptic transmission, dopaminergic (GO:0032225)	4.60052855
29	polyamine biosynthetic process (GO:0006596)	4.59258634
30	negative regulation of granulocyte differentiation (GO:0030853)	4.57430449
31	cGMP-mediated signaling (GO:0019934)	4.56143708
32	epithelial cilium movement (GO:0003351)	4.43163025
33	calcium ion-dependent exocytosis (GO:0017156)	4.31013826
34	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	4.23913076
35	activation of protein kinase B activity (GO:0032148)	4.19356310
36	centriole assembly (GO:0098534)	4.14750995
37	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	4.10322110
38	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.06759125
39	protein targeting to Golgi (GO:0000042)	4.01185448
40	mitochondrion degradation (GO:0000422)	3.99417532
41	cilium movement (GO:0003341)	3.98273776
42	establishment of protein localization to Golgi (GO:0072600)	3.95266713
43	male sex determination (GO:0030238)	3.95144144
44	protein polyglutamylation (GO:0018095)	3.87738502
45	coenzyme catabolic process (GO:0009109)	3.87553642
46	germ cell development (GO:0007281)	3.86419053
47	Leydig cell differentiation (GO:0033327)	3.84730651
48	fertilization (GO:0009566)	3.83219443
49	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.83143977
50	phosphatidylethanolamine metabolic process (GO:0046337)	3.80336175
51	cellular biogenic amine biosynthetic process (GO:0042401)	3.78625987
52	regulation of cellular respiration (GO:0043457)	3.78076712
53	TOR signaling (GO:0031929)	3.77038885
54	amine biosynthetic process (GO:0009309)	3.76477231
55	male gamete generation (GO:0048232)	3.73760324
56	negative regulation of response to reactive oxygen species (GO:1901032)	3.70892892
57	spermatogenesis (GO:0007283)	3.68667221
58	negative regulation of JNK cascade (GO:0046329)	3.64657221
59	microtubule nucleation (GO:0007020)	3.64379832
60	tongue development (GO:0043586)	3.63725896
61	regulation of ARF GTPase activity (GO:0032312)	3.61270405
62	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.58908709
63	synapsis (GO:0007129)	3.57414675
64	androgen biosynthetic process (GO:0006702)	3.54871154
65	ADP metabolic process (GO:0046031)	3.52732841
66	cellular response to pH (GO:0071467)	3.48647970
67	meiotic nuclear division (GO:0007126)	3.48313806
68	gamete generation (GO:0007276)	3.47364931
69	response to acidic pH (GO:0010447)	3.45599602
70	synaptonemal complex assembly (GO:0007130)	3.44484561
71	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.44289951
72	rRNA methylation (GO:0031167)	3.42030691
73	centriole replication (GO:0007099)	3.41658887
74	cellular response to toxic substance (GO:0097237)	3.38531981
75	chromosome organization involved in meiosis (GO:0070192)	3.35910252
76	oogenesis (GO:0048477)	3.34447226
77	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.34256808
78	acrosome assembly (GO:0001675)	3.24229590
79	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	3.22671732
80	negative regulation of stress-activated MAPK cascade (GO:0032873)	3.22671732
81	sleep (GO:0030431)	3.20968092
82	glycogen metabolic process (GO:0005977)	3.20906938
83	glucan metabolic process (GO:0044042)	3.17558172
84	cellular glucan metabolic process (GO:0006073)	3.17558172
85	protein polymerization (GO:0051258)	3.14621066
86	DNA methylation involved in gamete generation (GO:0043046)	3.14128118
87	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.10771458
88	positive regulation of glycolytic process (GO:0045821)	3.10590457
89	glutamine family amino acid catabolic process (GO:0009065)	3.09620371
90	synaptonemal complex organization (GO:0070193)	3.08805859
91	oligosaccharide biosynthetic process (GO:0009312)	3.08558916
92	histone exchange (GO:0043486)	3.05410121
93	sex determination (GO:0007530)	3.01530554
94	membrane repolarization during action potential (GO:0086011)	3.00382470
95	tachykinin receptor signaling pathway (GO:0007217)	2.99460192
96	negative regulation of macrophage differentiation (GO:0045650)	2.97052358
97	negative regulation of inclusion body assembly (GO:0090084)	2.94979490
98	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.94900046
99	positive regulation of amine transport (GO:0051954)	2.93971228
100	regulation of phosphatase activity (GO:0010921)	2.93867930

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.57254855
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.92390068
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.17294112
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.69562091
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.17645923
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.01304977
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.83776914
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.78613103
9	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.41135021
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.38676128
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07814227
12	FUS_26573619_Chip-Seq_HEK293_Human	2.02534472
13	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.97743511
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96836864
15	OCT4_20526341_ChIP-Seq_ESCs_Human	1.87914303
16	RAC3_21632823_ChIP-Seq_H3396_Human	1.83415695
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82558077
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81053598
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81053598
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.79419653
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.79419653
22	CTCF_27219007_Chip-Seq_Bcells_Human	1.76189120
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.70457015
24	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.65096281
25	ERA_21632823_ChIP-Seq_H3396_Human	1.64792059
26	SMC4_20622854_ChIP-Seq_HELA_Human	1.64712490
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.64307258
28	ERG_20517297_ChIP-Seq_VCAP_Human	1.59508068
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55919469
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.53325553
31	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.50551534
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49211965
33	MYC_19829295_ChIP-Seq_ESCs_Human	1.48327621
34	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.45880998
35	VDR_22108803_ChIP-Seq_LS180_Human	1.45444843
36	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44029587
37	P68_20966046_ChIP-Seq_HELA_Human	1.43293119
38	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.42960335
39	TBL1_22424771_ChIP-Seq_293T_Human	1.40879449
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39104717
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37501246
42	CTCF_20526341_ChIP-Seq_ESCs_Human	1.36974184
43	PHF8_20622854_ChIP-Seq_HELA_Human	1.36435905
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.36433292
45	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.35746448
46	SPI1_20517297_ChIP-Seq_HL60_Human	1.35326399
47	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.31558359
48	HOXB7_26014856_ChIP-Seq_BT474_Human	1.30626837
49	E2F1_20622854_ChIP-Seq_HELA_Human	1.29445920
50	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.29297019
51	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.28759128
52	P300_27268052_Chip-Seq_Bcells_Human	1.28441818
53	BCOR_27268052_Chip-Seq_Bcells_Human	1.27319674
54	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.26930541
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24059770
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23782891
57	BCL6_27268052_Chip-Seq_Bcells_Human	1.21123480
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18087217
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17557968
60	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.17195302
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16389342
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16333392
63	LXR_22292898_ChIP-Seq_THP-1_Human	1.13418976
64	OCT4_19829295_ChIP-Seq_ESCs_Human	1.12131517
65	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.11071444
66	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.10391614
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.09962219
68	NFYB_21822215_ChIP-Seq_K562_Human	1.09891400
69	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.09066856
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08713172
71	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.07483852
72	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.07223223
73	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07179983
74	AHR_22903824_ChIP-Seq_MCF-7_Human	1.05656675
75	PHF8_20622853_ChIP-Seq_HELA_Human	1.05526901
76	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.04172192
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03871766
78	RXR_22108803_ChIP-Seq_LS180_Human	1.02554022
79	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01582039
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.00471543
81	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.99894743
82	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.99357519
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97562579
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96558289
85	TP63_22573176_ChIP-Seq_HFKS_Human	0.96472792
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96366940
87	KLF4_19829295_ChIP-Seq_ESCs_Human	0.95622783
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94446274
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94255537
90	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.93073413
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92547921
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.92274927
93	STAT3_23295773_ChIP-Seq_U87_Human	0.91454953
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91239860
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89966313
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.88845252
97	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.88322785
98	MAF_26560356_Chip-Seq_TH2_Human	0.87112428
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86826003
100	NFYA_21822215_ChIP-Seq_K562_Human	0.85982620

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.25440174
2	MP0003806_abnormal_nucleotide_metabolis	7.24583817
3	MP0008004_abnormal_stomach_pH	5.97747816
4	MP0003315_abnormal_perineum_morphology	5.16903695
5	MP0003950_abnormal_plasma_membrane	3.24883196
6	MP0003698_abnormal_male_reproductive	2.97067305
7	MP0002160_abnormal_reproductive_system	2.88598984
8	MP0005360_urolithiasis	2.79472826
9	MP0001929_abnormal_gametogenesis	2.74038207
10	MP0001905_abnormal_dopamine_level	2.02593626
11	MP0005171_absent_coat_pigmentation	1.96395465
12	MP0005377_hearing/vestibular/ear_phenot	1.92452728
13	MP0003878_abnormal_ear_physiology	1.92452728
14	MP0005058_abnormal_lysosome_morphology	1.90841549
15	MP0000537_abnormal_urethra_morphology	1.81498178
16	MP0001984_abnormal_olfaction	1.77903793
17	MP0002132_abnormal_respiratory_system	1.73616325
18	MP0001664_abnormal_digestion	1.72709485
19	MP0008995_early_reproductive_senescence	1.65194705
20	MP0003136_yellow_coat_color	1.57012795
21	MP0009697_abnormal_copulation	1.56370591
22	MP0004084_abnormal_cardiac_muscle	1.54448405
23	MP0000749_muscle_degeneration	1.54312034
24	MP0005647_abnormal_sex_gland	1.53808832
25	MP0002210_abnormal_sex_determination	1.52097857
26	MP0002161_abnormal_fertility/fecundity	1.46220505
27	MP0003718_maternal_effect	1.39129107
28	MP0003045_fibrosis	1.31216467
29	MP0000470_abnormal_stomach_morphology	1.29071624
30	MP0002837_dystrophic_cardiac_calcinosis	1.28212498
31	MP0001145_abnormal_male_reproductive	1.27291365
32	MP0004036_abnormal_muscle_relaxation	1.26069743
33	MP0001501_abnormal_sleep_pattern	1.24765939
34	MP0005389_reproductive_system_phenotype	1.22848184
35	MP0003385_abnormal_body_wall	1.22814179
36	MP0003646_muscle_fatigue	1.21572603
37	MP0010386_abnormal_urinary_bladder	1.21163035
38	MP0005330_cardiomyopathy	1.19443328
39	MP0002249_abnormal_larynx_morphology	1.13398084
40	MP0005423_abnormal_somatic_nervous	1.12506273
41	MP0000538_abnormal_urinary_bladder	1.11893778
42	MP0000653_abnormal_sex_gland	1.11354446
43	MP0002102_abnormal_ear_morphology	1.10909346
44	MP0004885_abnormal_endolymph	1.10152737
45	MP0006276_abnormal_autonomic_nervous	1.06972005
46	MP0001968_abnormal_touch/_nociception	1.05733763
47	MP0001661_extended_life_span	1.04253342
48	MP0005174_abnormal_tail_pigmentation	1.02695476
49	MP0005253_abnormal_eye_physiology	1.01633778
50	MP0001188_hyperpigmentation	1.00463439
51	MP0005499_abnormal_olfactory_system	1.00136169
52	MP0005394_taste/olfaction_phenotype	1.00136169
53	MP0006072_abnormal_retinal_apoptosis	0.98576470
54	MP0001486_abnormal_startle_reflex	0.92880203
55	MP0006036_abnormal_mitochondrial_physio	0.92217468
56	MP0005551_abnormal_eye_electrophysiolog	0.90366141
57	MP0008058_abnormal_DNA_repair	0.89685486
58	MP0003879_abnormal_hair_cell	0.86832478
59	MP0010368_abnormal_lymphatic_system	0.85643382
60	MP0001529_abnormal_vocalization	0.84371094
61	MP0005266_abnormal_metabolism	0.83168361
62	MP0002928_abnormal_bile_duct	0.80036978
63	MP0003632_abnormal_nervous_system	0.75924657
64	MP0005646_abnormal_pituitary_gland	0.75537902
65	MP0005620_abnormal_muscle_contractility	0.75376348
66	MP0000747_muscle_weakness	0.75213700
67	MP0008875_abnormal_xenobiotic_pharmacok	0.72209634
68	MP0002127_abnormal_cardiovascular_syste	0.72084591
69	MP0003936_abnormal_reproductive_system	0.71184020
70	MP0001270_distended_abdomen	0.70432494
71	MP0001919_abnormal_reproductive_system	0.69952556
72	MP0005187_abnormal_penis_morphology	0.69738668
73	MP0000230_abnormal_systemic_arterial	0.69114766
74	MP0004085_abnormal_heartbeat	0.68173548
75	MP0001986_abnormal_taste_sensitivity	0.68049414
76	MP0005670_abnormal_white_adipose	0.63622043
77	MP0002269_muscular_atrophy	0.63142792
78	MP0003633_abnormal_nervous_system	0.62806821
79	MP0001485_abnormal_pinna_reflex	0.62581425
80	MP0003631_nervous_system_phenotype	0.62467797
81	MP0009745_abnormal_behavioral_response	0.62049768
82	MP0000026_abnormal_inner_ear	0.61633299
83	MP0009250_abnormal_appendicular_skeleto	0.61477785
84	MP0008775_abnormal_heart_ventricle	0.59402819
85	MP0000678_abnormal_parathyroid_gland	0.59021155
86	MP0004215_abnormal_myocardial_fiber	0.58624610
87	MP0002572_abnormal_emotion/affect_behav	0.58037079
88	MP0000343_altered_response_to	0.57204142
89	MP0002067_abnormal_sensory_capabilities	0.55341549
90	MP0005409_darkened_coat_color	0.54815995
91	MP0004145_abnormal_muscle_electrophysio	0.54056030
92	MP0003635_abnormal_synaptic_transmissio	0.53773873
93	MP0002108_abnormal_muscle_morphology	0.53584646
94	MP0001963_abnormal_hearing_physiology	0.53065198
95	MP0004087_abnormal_muscle_fiber	0.50082879
96	MP0002272_abnormal_nervous_system	0.49385713
97	MP0001849_ear_inflammation	0.47686308
98	MP0000631_abnormal_neuroendocrine_gland	0.46442339
99	MP0000759_abnormal_skeletal_muscle	0.44688062
100	MP0005395_other_phenotype	0.44621166

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Resting tremor (HP:0002322)	5.55570700
2	Abnormal sex determination (HP:0012244)	5.00597480
3	Sex reversal (HP:0012245)	5.00597480
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.86367829
5	Aplasia cutis congenita (HP:0001057)	4.74034327
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.68364033
7	Absent/shortened dynein arms (HP:0200106)	4.68364033
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.49712748
9	Abnormal ciliary motility (HP:0012262)	4.39478167
10	Facial hemangioma (HP:0000329)	4.28987532
11	Hypoplasia of the uterus (HP:0000013)	4.05669170
12	Postural instability (HP:0002172)	4.05047894
13	Reduced antithrombin III activity (HP:0001976)	4.04039639
14	Abnormality of the columella (HP:0009929)	3.88902096
15	Infertility (HP:0000789)	3.86452516
16	Germ cell neoplasia (HP:0100728)	3.77838911
17	Male pseudohermaphroditism (HP:0000037)	3.75874444
18	Colitis (HP:0002583)	3.62038140
19	Ventricular fibrillation (HP:0001663)	3.57999798
20	Gonadal dysgenesis (HP:0000133)	3.57372896
21	Congenital sensorineural hearing impairment (HP:0008527)	3.38556762
22	Abnormal respiratory motile cilium morphology (HP:0005938)	3.35862438
23	Abnormal respiratory epithelium morphology (HP:0012253)	3.35862438
24	Abnormality of the intrinsic pathway (HP:0010989)	3.30768007
25	Tubulointerstitial nephritis (HP:0001970)	3.23221000
26	Aplasia/hypoplasia of the uterus (HP:0008684)	3.17581093
27	Retinal dysplasia (HP:0007973)	3.16075472
28	Capillary hemangiomas (HP:0005306)	3.15344867
29	Chronic hepatic failure (HP:0100626)	3.11465867
30	Abnormality of lateral ventricle (HP:0030047)	3.07436501
31	Abnormality of the parietal bone (HP:0002696)	3.01908870
32	Vaginal fistula (HP:0004320)	2.88469950
33	Protruding tongue (HP:0010808)	2.73140154
34	Rectal fistula (HP:0100590)	2.72612780
35	Rectovaginal fistula (HP:0000143)	2.72612780
36	Abnormality of the aortic arch (HP:0012303)	2.69795003
37	Attenuation of retinal blood vessels (HP:0007843)	2.68851415
38	Exercise-induced myalgia (HP:0003738)	2.65261073
39	Abnormality of the thoracic spine (HP:0100711)	2.61671737
40	Type II lissencephaly (HP:0007260)	2.57881458
41	Intestinal fistula (HP:0100819)	2.57735565
42	Rhinitis (HP:0012384)	2.57217358
43	Cerebellar dysplasia (HP:0007033)	2.54190687
44	Atonic seizures (HP:0010819)	2.52879560
45	Ulnar bowing (HP:0003031)	2.51870695
46	Abnormality of macular pigmentation (HP:0008002)	2.49410762
47	Exercise-induced muscle cramps (HP:0003710)	2.48570433
48	Median cleft lip (HP:0000161)	2.47255857
49	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.40690076
50	Thoracic kyphosis (HP:0002942)	2.38506022
51	Calf muscle hypertrophy (HP:0008981)	2.36545491
52	Midline defect of the nose (HP:0004122)	2.36400408
53	Prolonged QT interval (HP:0001657)	2.35006375
54	Self-mutilation (HP:0000742)	2.34032358
55	Nasal polyposis (HP:0100582)	2.30465683
56	Muscle hypertrophy of the lower extremities (HP:0008968)	2.29707113
57	Pancreatic fibrosis (HP:0100732)	2.27463056
58	Inflammation of the large intestine (HP:0002037)	2.25106617
59	Clumsiness (HP:0002312)	2.24910449
60	Pancreatic cysts (HP:0001737)	2.20852930
61	Abnormality of the pons (HP:0007361)	2.17432694
62	Hypoplasia of the pons (HP:0012110)	2.17258393
63	Abnormality of cochlea (HP:0000375)	2.15981454
64	Gastrointestinal inflammation (HP:0004386)	2.15744381
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12826428
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.12826428
67	Abnormal protein glycosylation (HP:0012346)	2.12826428
68	Abnormal glycosylation (HP:0012345)	2.12826428
69	Urinary urgency (HP:0000012)	2.11486731
70	Bony spicule pigmentary retinopathy (HP:0007737)	2.09419049
71	Thoracolumbar scoliosis (HP:0002944)	2.06101853
72	Turricephaly (HP:0000262)	2.06027217
73	Absent thumb (HP:0009777)	2.03770418
74	Annular pancreas (HP:0001734)	2.00439373
75	Abnormality of male internal genitalia (HP:0000022)	1.99962502
76	Male infertility (HP:0003251)	1.99028226
77	Abnormality of the nasal mucosa (HP:0000433)	1.96897751
78	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.96832305
79	Acute lymphatic leukemia (HP:0006721)	1.95752660
80	Squamous cell carcinoma (HP:0002860)	1.95552497
81	Abnormality of the renal collecting system (HP:0004742)	1.92416727
82	Unsteady gait (HP:0002317)	1.91843861
83	Abnormality of dental color (HP:0011073)	1.90628007
84	Autoimmune thrombocytopenia (HP:0001973)	1.88504840
85	Cerebral hypomyelination (HP:0006808)	1.88235669
86	Hyporeflexia of lower limbs (HP:0002600)	1.85672453
87	Decreased central vision (HP:0007663)	1.85283724
88	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.82643088
89	Duplicated collecting system (HP:0000081)	1.80156555
90	Tinnitus (HP:0000360)	1.78689874
91	Syncope (HP:0001279)	1.78163649
92	Facial diplegia (HP:0001349)	1.77724789
93	Rhabdomyolysis (HP:0003201)	1.76605639
94	Sensory axonal neuropathy (HP:0003390)	1.75990948
95	EMG: myopathic abnormalities (HP:0003458)	1.74639421
96	Aplasia of the musculature (HP:0100854)	1.73071329
97	Myoglobinuria (HP:0002913)	1.71985393
98	Atrial fibrillation (HP:0005110)	1.71023513
99	Chronic bronchitis (HP:0004469)	1.69488476
100	Impulsivity (HP:0100710)	1.69176381

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.55261760
2	MARK3	5.08794957
3	TLK1	2.87036193
4	ZAK	2.64917094
5	OBSCN	2.43190059
6	PLK4	2.02288509
7	PINK1	10.7363240
8	MYLK	1.98793527
9	RPS6KA5	1.94301055
10	MAPK15	1.91535350
11	NEK2	1.80569596
12	STK16	1.72957745
13	LATS1	1.64631214
14	FRK	1.48777162
15	BRD4	1.32930277
16	INSRR	1.24720127
17	STK38	1.21289654
18	EEF2K	1.20180921
19	PDPK1	1.19229870
20	CDK3	1.08401801
21	STK38L	1.05874781
22	ADRBK2	1.05311210
23	PRKCQ	0.99691388
24	PDK1	0.95549495
25	ARAF	0.93218885
26	CDK12	0.92678858
27	MAPK13	0.89843491
28	LATS2	0.78958144
29	MAP3K9	0.78246922
30	MAPK12	0.77120860
31	IKBKE	0.76241602
32	BMPR1B	0.72166545
33	MUSK	0.70979498
34	TIE1	0.69198096
35	SGK223	0.65141227
36	SGK494	0.65141227
37	MST1R	0.63302618
38	MAP2K7	0.59591582
39	EIF2AK3	0.58759889
40	CDK14	0.58059770
41	PNCK	0.53854043
42	CAMK1	0.53621479
43	MAPK11	0.52157439
44	RPS6KB1	0.49059552
45	MAP3K1	0.47938546
46	PKN1	0.47471093
47	FGFR2	0.47041279
48	PRKG2	0.46499209
49	NME2	0.45946205
50	PAK1	0.45859302
51	PAK2	0.45813933
52	MAP3K13	0.45203506
53	VRK1	0.44454663
54	CSNK1A1	0.44191220
55	MAP3K7	0.42716562
56	PRKG1	0.42250721
57	MAPKAPK3	0.42070803
58	CAMK1G	0.41910566
59	DYRK3	0.40346177
60	GRK1	0.38629095
61	PRKAA1	0.38142208
62	PIK3CG	0.38080690
63	KDR	0.37999847
64	ROCK1	0.37114346
65	MTOR	0.36465151
66	MAP3K5	0.35527621
67	ATM	0.34569880
68	PRKD3	0.34342816
69	PLK2	0.34148421
70	MELK	0.33300928
71	RPS6KA1	0.31372245
72	MAP3K10	0.30828323
73	CHEK2	0.30683731
74	TEC	0.30469486
75	PTK2B	0.30319522
76	TNK2	0.29852669
77	CDC42BPA	0.29498797
78	AKT2	0.28598723
79	CDK8	0.28022896
80	CSNK1D	0.27253376
81	MAPK1	0.26036652
82	MAP2K6	0.25424871
83	CSNK1A1L	0.25135265
84	PASK	0.24384703
85	GSK3B	0.24224582
86	WNK1	0.23770798
87	EGFR	0.23125138
88	CCNB1	0.22855621
89	TRPM7	0.22816141
90	PLK1	0.20562562
91	RPS6KA2	0.20187594
92	RPS6KA3	0.19597750
93	BTK	0.19458407
94	CSNK1E	0.19116505
95	AURKA	0.18780736
96	CDK5	0.18630096
97	PRKAA2	0.18618422
98	RPS6KA4	0.18327799
99	MOS	0.17824420
100	TYRO3	0.17187712

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	5.42961662
2	Gap junction_Homo sapiens_hsa04540	4.11844265
3	Olfactory transduction_Homo sapiens_hsa04740	3.87131513
4	Nitrogen metabolism_Homo sapiens_hsa00910	3.42051248
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.70575129
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.70518816
7	Alcoholism_Homo sapiens_hsa05034	2.29771373
8	Apoptosis_Homo sapiens_hsa04210	2.23055013
9	Arginine biosynthesis_Homo sapiens_hsa00220	1.97593738
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91984452
11	Taste transduction_Homo sapiens_hsa04742	1.90811497
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.81637839
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.75496986
14	Phagosome_Homo sapiens_hsa04145	1.67267364
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.60808866
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.59381824
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.50885872
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.49814922
19	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.48810458
20	Sulfur relay system_Homo sapiens_hsa04122	1.40460521
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34176196
22	Basal transcription factors_Homo sapiens_hsa03022	1.32033965
23	Glutathione metabolism_Homo sapiens_hsa00480	1.31322288
24	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.28230722
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.24898583
26	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24107055
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22080420
28	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.20889928
29	RNA transport_Homo sapiens_hsa03013	1.19424293
30	Propanoate metabolism_Homo sapiens_hsa00640	1.17929408
31	Butanoate metabolism_Homo sapiens_hsa00650	1.17684975
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15694788
33	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.12614651
34	Regulation of autophagy_Homo sapiens_hsa04140	1.07439570
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.04133487
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02105526
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98201234
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.98194755
39	Purine metabolism_Homo sapiens_hsa00230	0.94714723
40	Phototransduction_Homo sapiens_hsa04744	0.92362698
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87736921
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87396381
43	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.85473173
44	Homologous recombination_Homo sapiens_hsa03440	0.85010591
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83929457
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83199051
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.83111320
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79212727
49	Gastric acid secretion_Homo sapiens_hsa04971	0.78095461
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73065178
51	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.68751028
52	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68412785
53	Glucagon signaling pathway_Homo sapiens_hsa04922	0.68319581
54	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66798484
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65701649
56	Oocyte meiosis_Homo sapiens_hsa04114	0.63985067
57	Parkinsons disease_Homo sapiens_hsa05012	0.63941834
58	Cholinergic synapse_Homo sapiens_hsa04725	0.59491252
59	GABAergic synapse_Homo sapiens_hsa04727	0.56608940
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52003225
61	PPAR signaling pathway_Homo sapiens_hsa03320	0.51701876
62	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51693505
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.51497585
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51194759
65	Circadian rhythm_Homo sapiens_hsa04710	0.50797336
66	Morphine addiction_Homo sapiens_hsa05032	0.50536244
67	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50495320
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.49373190
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47781562
70	Nicotine addiction_Homo sapiens_hsa05033	0.46913657
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46787179
72	Renin secretion_Homo sapiens_hsa04924	0.46674023
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.44885325
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.44053122
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42691513
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42526848
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42196847
78	Pancreatic secretion_Homo sapiens_hsa04972	0.41094073
79	Circadian entrainment_Homo sapiens_hsa04713	0.39134730
80	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.37491183
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.37467856
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.35034177
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.34495116
84	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.33626867
85	Phenylalanine metabolism_Homo sapiens_hsa00360	0.33281348
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33031483
87	Retinol metabolism_Homo sapiens_hsa00830	0.30737890
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.30609381
89	Metabolic pathways_Homo sapiens_hsa01100	0.30579525
90	AMPK signaling pathway_Homo sapiens_hsa04152	0.29768144
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28869168
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27976113
93	Amphetamine addiction_Homo sapiens_hsa05031	0.27337355
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26983237
95	Cocaine addiction_Homo sapiens_hsa05030	0.26710287
96	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.25912112
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.25578576
98	Fatty acid degradation_Homo sapiens_hsa00071	0.24809445
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.23206782
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.22985383

IQCA1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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