IQCF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.96385268
2reproduction (GO:0000003)9.76124415
3epithelial cilium movement (GO:0003351)9.67655528
4spermatid development (GO:0007286)9.60564745
5axonemal dynein complex assembly (GO:0070286)9.15511174
6motile cilium assembly (GO:0044458)8.97207887
7regulation of cilium movement (GO:0003352)7.70017812
8cilium movement (GO:0003341)7.68778873
9cilium or flagellum-dependent cell motility (GO:0001539)7.64207020
10response to pheromone (GO:0019236)7.34552173
11synaptonemal complex assembly (GO:0007130)7.24015205
12synaptonemal complex organization (GO:0070193)7.16328435
13single fertilization (GO:0007338)7.15774850
14sperm capacitation (GO:0048240)7.03693243
15negative regulation of inclusion body assembly (GO:0090084)6.94867096
16spermatid nucleus differentiation (GO:0007289)6.92422762
17male meiosis (GO:0007140)6.89303367
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.88647926
19microtubule depolymerization (GO:0007019)6.74604866
20spermatogenesis (GO:0007283)6.58281531
21male gamete generation (GO:0048232)6.56018533
22rRNA methylation (GO:0031167)6.41368490
23organic cation transport (GO:0015695)6.19927971
24piRNA metabolic process (GO:0034587)6.10925909
25gamete generation (GO:0007276)6.05906355
26fertilization (GO:0009566)6.00111603
27regulation of inclusion body assembly (GO:0090083)5.91174734
28rRNA modification (GO:0000154)5.88008988
29sexual reproduction (GO:0019953)5.85088150
30protein targeting to Golgi (GO:0000042)5.72643119
31chromosome condensation (GO:0030261)5.64201556
32single strand break repair (GO:0000012)5.63496043
33regulation of meiosis I (GO:0060631)5.58965248
34calcium ion-dependent exocytosis (GO:0017156)5.58571040
35establishment of protein localization to Golgi (GO:0072600)5.57130517
36germ cell development (GO:0007281)5.28834388
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.26583803
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.24271719
39DNA packaging (GO:0006323)5.23220122
40glycerol ether metabolic process (GO:0006662)5.02619816
41cell recognition (GO:0008037)4.96788940
42microtubule severing (GO:0051013)4.93271586
43chromosome organization involved in meiosis (GO:0070192)4.83599008
44cellular ketone body metabolic process (GO:0046950)4.81987216
45multicellular organismal reproductive process (GO:0048609)4.75095088
46negative regulation of response to food (GO:0032096)4.72146715
47negative regulation of appetite (GO:0032099)4.72146715
48drinking behavior (GO:0042756)4.67071700
49ether metabolic process (GO:0018904)4.64225964
50phosphatidylethanolamine biosynthetic process (GO:0006646)4.61898342
51ventricular system development (GO:0021591)4.59935365
52regulation of microtubule-based movement (GO:0060632)4.45118597
53ketone body metabolic process (GO:1902224)4.43533636
54phosphatidylethanolamine metabolic process (GO:0046337)4.37230632
55male meiosis I (GO:0007141)4.35582724
56positive regulation of vascular permeability (GO:0043117)4.31331895
57protein localization to Golgi apparatus (GO:0034067)4.28305939
58regulation of centriole replication (GO:0046599)4.18896086
59meiotic nuclear division (GO:0007126)4.18454809
60seminiferous tubule development (GO:0072520)4.17487821
61protein K11-linked deubiquitination (GO:0035871)4.12976897
62negative regulation of digestive system process (GO:0060457)4.11725227
63monoubiquitinated protein deubiquitination (GO:0035520)4.09221171
64DNA methylation involved in gamete generation (GO:0043046)4.04262774
65chaperone-mediated protein complex assembly (GO:0051131)3.98946930
66microtubule nucleation (GO:0007020)3.79176741
67sequestering of actin monomers (GO:0042989)3.76922528
68multicellular organismal development (GO:0007275)3.76850164
69regulation of appetite (GO:0032098)3.74989857
70hormone catabolic process (GO:0042447)3.74212880
71peptide catabolic process (GO:0043171)3.73657194
72positive regulation of meiosis (GO:0045836)3.73267912
73detection of light stimulus involved in sensory perception (GO:0050962)3.61812181
74detection of light stimulus involved in visual perception (GO:0050908)3.61812181
75microtubule polymerization or depolymerization (GO:0031109)3.59274288
76meiosis I (GO:0007127)3.59064918
77positive regulation of meiotic cell cycle (GO:0051446)3.53885123
78left/right pattern formation (GO:0060972)3.50341856
79nucleus organization (GO:0006997)3.45490190
80protein polyglutamylation (GO:0018095)3.31190536
81regulation of Rab GTPase activity (GO:0032313)3.30582450
82positive regulation of Rab GTPase activity (GO:0032851)3.30582450
83genitalia morphogenesis (GO:0035112)3.29407474
84chromatin silencing (GO:0006342)3.28660681
85regulation of spindle checkpoint (GO:0090231)3.28616436
86snRNA transcription (GO:0009301)3.26989209
87polyamine biosynthetic process (GO:0006596)3.22919420
88regulation of response to food (GO:0032095)3.18450821
89positive regulation of macrophage activation (GO:0043032)3.18164548
90meiotic cell cycle (GO:0051321)3.12366777
91grooming behavior (GO:0007625)3.12011241
92protein refolding (GO:0042026)3.09314470
93regulation of transcription involved in cell fate commitment (GO:0060850)3.08009726
94interferon-gamma secretion (GO:0072643)3.06441041
95cofactor catabolic process (GO:0051187)3.03538917
96mitotic sister chromatid cohesion (GO:0007064)3.02995867
97RNA destabilization (GO:0050779)3.00091471
98glycolytic process (GO:0006096)2.97085007
99photoreceptor cell maintenance (GO:0045494)2.95738370
100nucleoside diphosphate phosphorylation (GO:0006165)2.92801886
101polyol catabolic process (GO:0046174)2.91437187
102cellular response to ATP (GO:0071318)2.89653997
103meiotic cell cycle process (GO:1903046)2.87502226
104arginine catabolic process (GO:0006527)2.86723322
105nonmotile primary cilium assembly (GO:0035058)2.82561943
106musculoskeletal movement (GO:0050881)2.82010402
107multicellular organismal movement (GO:0050879)2.82010402
108amino-acid betaine transport (GO:0015838)2.80638106
109carnitine transport (GO:0015879)2.80638106
110coenzyme catabolic process (GO:0009109)2.79881092
111GTP biosynthetic process (GO:0006183)2.78275034
112alditol metabolic process (GO:0019400)2.78013794
113negative regulation of cell size (GO:0045792)2.75260980
114positive regulation of calcium ion import (GO:0090280)2.69890641
115histone exchange (GO:0043486)2.69871923
116determination of adult lifespan (GO:0008340)2.67549320
117centriole assembly (GO:0098534)2.66596928
118regulation of feeding behavior (GO:0060259)2.64877504
119protein localization to chromosome, centromeric region (GO:0071459)2.64795123
120carnitine transmembrane transport (GO:1902603)2.63861360
121cilium organization (GO:0044782)2.62394507
122nucleosome disassembly (GO:0006337)2.61341390
123protein-DNA complex disassembly (GO:0032986)2.61341390
124cellular response to arsenic-containing substance (GO:0071243)2.61015752
125synapsis (GO:0007129)2.59360032
126cellular component assembly involved in morphogenesis (GO:0010927)2.53199809
127cilium assembly (GO:0042384)2.52433789
128peptidyl-threonine dephosphorylation (GO:0035970)2.52183213
129negative regulation of gene expression, epigenetic (GO:0045814)2.51564589
130UTP biosynthetic process (GO:0006228)2.49691890
131microtubule-based movement (GO:0007018)2.46956825
132regulation of cilium assembly (GO:1902017)2.43830154
133cilium morphogenesis (GO:0060271)2.40979151
134centriole replication (GO:0007099)2.38402101
135gene silencing (GO:0016458)2.38096291
136cell wall macromolecule catabolic process (GO:0016998)15.4769109
137cell wall macromolecule metabolic process (GO:0044036)15.4769109
138sperm motility (GO:0030317)13.6720578
139fusion of sperm to egg plasma membrane (GO:0007342)13.0798229
140acrosome reaction (GO:0007340)11.8397022
141acrosome assembly (GO:0001675)11.8110184
142sperm-egg recognition (GO:0035036)11.5171254
143multicellular organism reproduction (GO:0032504)10.8784906
144binding of sperm to zona pellucida (GO:0007339)10.4577395
145cell-cell recognition (GO:0009988)10.3116192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.24040247
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.05549433
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.16356695
4EZH2_22144423_ChIP-Seq_EOC_Human3.12013587
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09029147
6IGF1R_20145208_ChIP-Seq_DFB_Human2.67942834
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64164123
8TAF15_26573619_Chip-Seq_HEK293_Human2.62861314
9FUS_26573619_Chip-Seq_HEK293_Human2.61975991
10GBX2_23144817_ChIP-Seq_PC3_Human2.60015537
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58061135
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57132986
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51607780
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.43596316
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.38763401
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.37450332
17VDR_22108803_ChIP-Seq_LS180_Human2.34137522
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.32305729
19P300_19829295_ChIP-Seq_ESCs_Human2.15325020
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.14358708
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.12546082
22ER_23166858_ChIP-Seq_MCF-7_Human2.06572295
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04732850
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04032815
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02547602
26KAP1_22055183_ChIP-Seq_ESCs_Mouse2.02323915
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.94454244
28ZNF274_21170338_ChIP-Seq_K562_Hela1.88654992
29AR_25329375_ChIP-Seq_VCAP_Human1.81968661
30STAT1_17558387_ChIP-Seq_HELA_Human1.80534482
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79902083
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.75159712
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73792580
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73071722
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71837321
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71417271
37GATA3_21867929_ChIP-Seq_CD8_Mouse1.69588033
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.68810604
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.68227757
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.68136073
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66365083
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.66082446
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65362949
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.64396391
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.63411303
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62704458
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.61573482
48SMAD4_21799915_ChIP-Seq_A2780_Human1.60961577
49KDM2B_26808549_Chip-Seq_REH_Human1.59121201
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.58443780
51STAT3_23295773_ChIP-Seq_U87_Human1.57171219
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.54300780
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.44261227
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41769466
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41617365
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.41101988
57GATA3_21867929_ChIP-Seq_TH1_Mouse1.40865477
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.40717003
59AR_21572438_ChIP-Seq_LNCaP_Human1.40591741
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.40123142
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39931212
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39160722
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39009812
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.38343720
65SOX2_19829295_ChIP-Seq_ESCs_Human1.38327170
66NANOG_19829295_ChIP-Seq_ESCs_Human1.38327170
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38046357
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37618487
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37388805
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36779355
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35832834
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35717546
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35486576
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.35486576
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35175676
76RUNX2_22187159_ChIP-Seq_PCA_Human1.34798155
77* TCF4_23295773_ChIP-Seq_U87_Human1.33523798
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.33099319
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30996028
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30707573
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.30250527
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30076411
83CBP_20019798_ChIP-Seq_JUKART_Human1.30015058
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30015058
85MYC_19829295_ChIP-Seq_ESCs_Human1.29447500
86NCOR_22424771_ChIP-Seq_293T_Human1.29215605
87TBL1_22424771_ChIP-Seq_293T_Human1.28641411
88NANOG_20526341_ChIP-Seq_ESCs_Human1.28316224
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28232280
90* P53_21459846_ChIP-Seq_SAOS-2_Human1.28151139
91ERA_21632823_ChIP-Seq_H3396_Human1.26508063
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26474082
93GF1_26923725_Chip-Seq_HPCs_Mouse1.26316846
94PHF8_20622853_ChIP-Seq_HELA_Human1.26117970
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.25027135
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24610107
97REST_21632747_ChIP-Seq_MESCs_Mouse1.23607082
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.23374720
99HOXB7_26014856_ChIP-Seq_BT474_Human1.22944040
100CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22890317
101ETV1_20927104_ChIP-Seq_GIST48_Human1.22826041
102BCAT_22108803_ChIP-Seq_LS180_Human1.22592528
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.21986852
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21851000
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21080534
106EWS_26573619_Chip-Seq_HEK293_Human1.20943696
107NFYA_21822215_ChIP-Seq_K562_Human1.20412396
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.20045392
109RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19991586
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19622487
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18404587
112RBPJ_21746931_ChIP-Seq_IB4_Human1.17853951
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17489819
114CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16587728
115CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16082516
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15813369
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14680954
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14393472
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14303703
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14303703
121RAC3_21632823_ChIP-Seq_H3396_Human1.14171603
122OCT4_18555785_Chip-Seq_ESCs_Mouse1.14078842
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13805791
124ESET_19884257_ChIP-Seq_ESCs_Mouse1.13570678
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.12819720
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11858273
127PIAS1_25552417_ChIP-Seq_VCAP_Human1.11784241
128P53_22387025_ChIP-Seq_ESCs_Mouse1.11516453
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10546236
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10321614
131KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10010497
132TCF4_22108803_ChIP-Seq_LS180_Human1.09993439
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09286263
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09037318
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08894976
136TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08783331
137* OCT4_20526341_ChIP-Seq_ESCs_Human1.08496316
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.07559723
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07331133
140RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06145028
141GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06133154
142GATA6_21074721_ChIP-Seq_CACO-2_Human1.05740567
143SALL4_22934838_ChIP-ChIP_CD34+_Human1.03922951
144P300_18555785_Chip-Seq_ESCs_Mouse1.03373912
145CEBPB_22108803_ChIP-Seq_LS180_Human1.03142790
146ERG_20517297_ChIP-Seq_VCAP_Human1.02520419
147CDX2_22108803_ChIP-Seq_LS180_Human1.02451292
148RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02372107
149KLF4_18555785_Chip-Seq_ESCs_Mouse1.01949253
150RARA_24833708_ChIP-Seq_LIVER_Mouse1.01879999
151FLI1_21867929_ChIP-Seq_CD8_Mouse1.01811423
152OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00688645
153* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99819232
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99653913
155ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98578171
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98339730
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97721760
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97229139
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97192785
160EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96589308
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.96545084
162SOX9_26525672_Chip-Seq_HEART_Mouse0.96137914
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.95162189
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.95122853
165GF1B_26923725_Chip-Seq_HPCs_Mouse0.94600070
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.94590784
167JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93778720
168NFYB_21822215_ChIP-Seq_K562_Human0.93487727
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.92654079
170RNF2_27304074_Chip-Seq_NSC_Mouse0.92622446
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91070278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.13327069
2MP0001929_abnormal_gametogenesis5.76559520
3MP0008877_abnormal_DNA_methylation4.03051823
4MP0002210_abnormal_sex_determination3.52756285
5MP0002161_abnormal_fertility/fecundity3.40536737
6MP0001145_abnormal_male_reproductive2.99705267
7MP0000653_abnormal_sex_gland2.64662994
8MP0005670_abnormal_white_adipose2.63327777
9MP0000678_abnormal_parathyroid_gland2.58303838
10MP0002837_dystrophic_cardiac_calcinosis2.50055030
11MP0005379_endocrine/exocrine_gland_phen2.42416716
12MP0002653_abnormal_ependyma_morphology2.42390697
13MP0000569_abnormal_digit_pigmentation2.34099380
14MP0002396_abnormal_hematopoietic_system2.23730915
15MP0001486_abnormal_startle_reflex2.20337015
16MP0005410_abnormal_fertilization16.2488391
17MP0005174_abnormal_tail_pigmentation1.85281622
18MP0003136_yellow_coat_color1.84760920
19MP0006072_abnormal_retinal_apoptosis1.71991816
20MP0000372_irregular_coat_pigmentation1.64773426
21MP0002160_abnormal_reproductive_system1.62371930
22MP0003646_muscle_fatigue1.57831123
23MP0004233_abnormal_muscle_weight1.51296036
24MP0000749_muscle_degeneration1.49165720
25MP0001485_abnormal_pinna_reflex1.47049944
26MP0000015_abnormal_ear_pigmentation1.46646813
27MP0005084_abnormal_gallbladder_morpholo1.44951007
28MP0001905_abnormal_dopamine_level1.39578080
29MP0008058_abnormal_DNA_repair1.36315048
30MP0009697_abnormal_copulation1.34547485
31MP0001348_abnormal_lacrimal_gland1.33888707
32MP0002138_abnormal_hepatobiliary_system1.29064610
33MP0005167_abnormal_blood-brain_barrier1.26438018
34MP0005645_abnormal_hypothalamus_physiol1.22244181
35MP0002735_abnormal_chemical_nociception1.18541063
36MP0000013_abnormal_adipose_tissue1.17369976
37MP0005623_abnormal_meninges_morphology1.16729640
38MP0005395_other_phenotype1.16375396
39MP0001963_abnormal_hearing_physiology1.15840917
40MP0008789_abnormal_olfactory_epithelium1.14074855
41MP0002572_abnormal_emotion/affect_behav1.11605683
42MP0004381_abnormal_hair_follicle1.10545667
43MP0001765_abnormal_ion_homeostasis1.09329783
44MP0000026_abnormal_inner_ear1.09168847
45MP0002557_abnormal_social/conspecific_i1.08213295
46MP0002272_abnormal_nervous_system1.07364403
47MP0005171_absent_coat_pigmentation1.06261967
48MP0002254_reproductive_system_inflammat1.05926623
49MP0002127_abnormal_cardiovascular_syste1.03019952
50MP0004742_abnormal_vestibular_system1.01194271
51MP0002234_abnormal_pharynx_morphology1.00561381
52MP0005310_abnormal_salivary_gland0.98087092
53MP0002282_abnormal_trachea_morphology0.97787785
54MP0009745_abnormal_behavioral_response0.95983495
55MP0002229_neurodegeneration0.92842924
56MP0002102_abnormal_ear_morphology0.92449044
57MP0001984_abnormal_olfaction0.92274839
58MP0002067_abnormal_sensory_capabilities0.90262950
59MP0003880_abnormal_central_pattern0.86966030
60MP0005647_abnormal_sex_gland0.85937617
61MP0010094_abnormal_chromosome_stability0.85546633
62MP0003632_abnormal_nervous_system0.85155870
63MP0003656_abnormal_erythrocyte_physiolo0.84756430
64MP0005389_reproductive_system_phenotype0.83561028
65MP0002822_catalepsy0.82608881
66MP0003111_abnormal_nucleus_morphology0.81130443
67MP0000516_abnormal_urinary_system0.80030911
68MP0005367_renal/urinary_system_phenotyp0.80030911
69MP0004924_abnormal_behavior0.80030239
70MP0005386_behavior/neurological_phenoty0.80030239
71MP0008875_abnormal_xenobiotic_pharmacok0.79876672
72MP0005075_abnormal_melanosome_morpholog0.79519583
73MP0009046_muscle_twitch0.77600067
74MP0000383_abnormal_hair_follicle0.76802140
75MP0010368_abnormal_lymphatic_system0.74943606
76MP0004085_abnormal_heartbeat0.74368799
77MP0004215_abnormal_myocardial_fiber0.73468089
78MP0002733_abnormal_thermal_nociception0.72760974
79MP0002095_abnormal_skin_pigmentation0.72709770
80MP0005332_abnormal_amino_acid0.72328368
81MP0005408_hypopigmentation0.71931583
82MP0005423_abnormal_somatic_nervous0.71334379
83MP0000371_diluted_coat_color0.71129601
84MP0002938_white_spotting0.69547141
85MP0000230_abnormal_systemic_arterial0.66255198
86MP0006292_abnormal_olfactory_placode0.65980674
87MP0003699_abnormal_female_reproductive0.64619464
88MP0005636_abnormal_mineral_homeostasis0.63414502
89MP0003115_abnormal_respiratory_system0.63074250
90MP0008872_abnormal_physiological_respon0.62799524
91MP0008995_early_reproductive_senescence0.62472392
92MP0000427_abnormal_hair_cycle0.61773353
93MP0008057_abnormal_DNA_replication0.55337391
94MP0005666_abnormal_adipose_tissue0.54337430
95MP0001730_embryonic_growth_arrest0.53299521
96MP0004036_abnormal_muscle_relaxation0.52495368
97MP0001764_abnormal_homeostasis0.52379707
98MP0005451_abnormal_body_composition0.50612623
99MP0001119_abnormal_female_reproductive0.49206454
100MP0006036_abnormal_mitochondrial_physio0.48282432
101MP0010307_abnormal_tumor_latency0.47868645
102MP0003693_abnormal_embryo_hatching0.47693756
103MP0000358_abnormal_cell_content/0.46468645
104MP0003077_abnormal_cell_cycle0.45814650
105MP0001293_anophthalmia0.45572655
106MP0002269_muscular_atrophy0.44418933
107MP0001324_abnormal_eye_pigmentation0.42657312
108MP0002736_abnormal_nociception_after0.41645258
109MP0003878_abnormal_ear_physiology0.41090703
110MP0005377_hearing/vestibular/ear_phenot0.41090703
111MP0003011_delayed_dark_adaptation0.37979919
112MP0003329_amyloid_beta_deposits0.37490077
113MP0001545_abnormal_hematopoietic_system0.36728478
114MP0005397_hematopoietic_system_phenotyp0.36728478
115MP0002928_abnormal_bile_duct0.36497422
116MP0004019_abnormal_vitamin_homeostasis0.36043457
117MP0009115_abnormal_fat_cell0.35453500
118MP0002132_abnormal_respiratory_system0.34605768
119MP0005551_abnormal_eye_electrophysiolog0.33592128
120MP0003718_maternal_effect0.33481172
121MP0004957_abnormal_blastocyst_morpholog0.33379194
122MP0001672_abnormal_embryogenesis/_devel0.33010778
123MP0005380_embryogenesis_phenotype0.33010778
124MP0002084_abnormal_developmental_patter0.32472067
125MP0003950_abnormal_plasma_membrane0.31886299
126MP0001849_ear_inflammation0.30874334
127MP0001697_abnormal_embryo_size0.30359715
128MP0003861_abnormal_nervous_system0.30215749
129MP0002169_no_abnormal_phenotype0.29225708
130MP0005253_abnormal_eye_physiology0.28891586
131MP0002873_normal_phenotype0.28877137
132MP0002971_abnormal_brown_adipose0.28272107
133MP0003786_premature_aging0.27991980
134MP0008007_abnormal_cellular_replicative0.27636784
135MP0005391_vision/eye_phenotype0.26228918
136MP0002085_abnormal_embryonic_tissue0.25403270
137MP0003984_embryonic_growth_retardation0.25278985
138MP0003315_abnormal_perineum_morphology0.25142202
139MP0002163_abnormal_gland_morphology0.24020124
140MP0004084_abnormal_cardiac_muscle0.23679254
141MP0004145_abnormal_muscle_electrophysio0.23487879
142MP0000313_abnormal_cell_death0.23369193
143MP0006035_abnormal_mitochondrial_morpho0.23354593
144MP0000534_abnormal_ureter_morphology0.22880426
145MP0002088_abnormal_embryonic_growth/wei0.22501161
146MP0005187_abnormal_penis_morphology0.22180905
147MP0002080_prenatal_lethality0.22057498
148MP0002152_abnormal_brain_morphology0.21921478
149MP0000462_abnormal_digestive_system0.21788641
150MP0009250_abnormal_appendicular_skeleto0.21114756
151MP0001968_abnormal_touch/_nociception0.21097822
152MP0003879_abnormal_hair_cell0.19911213
153MP0004811_abnormal_neuron_physiology0.18812790
154MP0000001_mammalian_phenotype0.18197432
155MP0003633_abnormal_nervous_system0.18151408
156MP0001529_abnormal_vocalization0.17735859
157MP0002092_abnormal_eye_morphology0.17101317
158MP0002139_abnormal_hepatobiliary_system0.16904737
159MP0002693_abnormal_pancreas_physiology0.16785492
160MP0001661_extended_life_span0.16658186
161MP0000579_abnormal_nail_morphology0.16401741
162MP0009672_abnormal_birth_weight0.16380261
163MP0003631_nervous_system_phenotype0.16353649

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.40482672
2Abnormal respiratory motile cilium morphology (HP:0005938)9.25191106
3Abnormal respiratory epithelium morphology (HP:0012253)9.25191106
4Chronic bronchitis (HP:0004469)7.64720430
5Rhinitis (HP:0012384)7.48639851
6Abnormal ciliary motility (HP:0012262)7.45581531
7Infertility (HP:0000789)6.83974166
8Nasal polyposis (HP:0100582)6.15499175
9Severe visual impairment (HP:0001141)5.70793229
10Generalized aminoaciduria (HP:0002909)5.08215594
11Male infertility (HP:0003251)5.07907294
12Abnormality of the nasal mucosa (HP:0000433)5.01686978
13Abnormality of the costochondral junction (HP:0000919)4.74107083
14Hypophosphatemic rickets (HP:0004912)4.71726943
15Renal Fanconi syndrome (HP:0001994)4.53833423
16Bronchitis (HP:0012387)4.45526919
17Bronchiectasis (HP:0002110)4.37198090
18Failure to thrive in infancy (HP:0001531)4.09635523
19Abnormal spermatogenesis (HP:0008669)3.90781199
20Nephronophthisis (HP:0000090)3.80818798
21Chronic hepatic failure (HP:0100626)3.75350758
22Abnormality of macular pigmentation (HP:0008002)3.66536581
23Attenuation of retinal blood vessels (HP:0007843)3.65288662
24Hyperkalemia (HP:0002153)3.63410833
25Portal hypertension (HP:0001409)3.37100865
26Tetany (HP:0001281)3.35375340
27Polyuria (HP:0000103)3.33365530
28Recurrent sinusitis (HP:0011108)3.31176327
29Recurrent otitis media (HP:0000403)3.24798712
30Bony spicule pigmentary retinopathy (HP:0007737)3.16836093
31Abnormality of renal resorption (HP:0011038)3.06020965
32Recurrent corneal erosions (HP:0000495)3.05577164
33Abnormality of the hepatic vasculature (HP:0006707)3.05326415
34Abnormality of potassium homeostasis (HP:0011042)3.01367191
35Hyponatremia (HP:0002902)2.98623296
36Medial flaring of the eyebrow (HP:0010747)2.83308151
37Abnormality of the renal medulla (HP:0100957)2.82078336
38Molar tooth sign on MRI (HP:0002419)2.72814638
39Abnormality of midbrain morphology (HP:0002418)2.72814638
40Abnormal rod and cone electroretinograms (HP:0008323)2.72393732
41Azoospermia (HP:0000027)2.71613733
42Impulsivity (HP:0100710)2.69097951
43Tubulointerstitial nephritis (HP:0001970)2.60070138
44Glycosuria (HP:0003076)2.60010424
45Abnormality of urine glucose concentration (HP:0011016)2.60010424
46Amelogenesis imperfecta (HP:0000705)2.58519618
47Hypokalemia (HP:0002900)2.45865644
48Horizontal nystagmus (HP:0000666)2.43712799
49Tubular atrophy (HP:0000092)2.41843414
50Recurrent bronchitis (HP:0002837)2.32731245
51Rickets (HP:0002748)2.32677953
52Hypoglycemic seizures (HP:0002173)2.30849806
53Delayed puberty (HP:0000823)2.29630761
54Cone-rod dystrophy (HP:0000548)2.28170254
55Abnormality of sodium homeostasis (HP:0010931)2.25079700
56Enlarged epiphyses (HP:0010580)2.22911088
57Hypoplastic ischia (HP:0003175)2.22462507
58Tubulointerstitial abnormality (HP:0001969)2.18580188
59Median cleft lip (HP:0000161)2.17834226
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.16155586
61Congenital malformation of the right heart (HP:0011723)2.13617872
62Double outlet right ventricle (HP:0001719)2.13617872
63Exocrine pancreatic insufficiency (HP:0001738)2.12259359
64Potter facies (HP:0002009)2.09936653
65Facial shape deformation (HP:0011334)2.09936653
66Progressive cerebellar ataxia (HP:0002073)2.09739046
67Hypoplasia of the thymus (HP:0000778)2.08777395
68Aplasia/Hypoplasia of the earlobes (HP:0009906)2.08343088
69Absent/shortened dynein arms (HP:0200106)13.1965847
70Dynein arm defect of respiratory motile cilia (HP:0012255)13.1965847
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1696725
72Resting tremor (HP:0002322)1.99293022
73Truncal obesity (HP:0001956)1.99076046
74Photophobia (HP:0000613)1.96317790
75Type II lissencephaly (HP:0007260)1.95089201
76Abnormal gallbladder physiology (HP:0012438)1.94060510
77Cholecystitis (HP:0001082)1.94060510
78Increased circulating renin level (HP:0000848)1.93724825
79Scotoma (HP:0000575)1.87485674
80Abnormality of alanine metabolism (HP:0010916)1.86656635
81Hyperalaninemia (HP:0003348)1.86656635
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86656635
83Volvulus (HP:0002580)1.86220046
84Pendular nystagmus (HP:0012043)1.86012966
85Congenital stationary night blindness (HP:0007642)1.85914929
86Intellectual disability, moderate (HP:0002342)1.84388188
87Bundle branch block (HP:0011710)1.83537982
88Dyschromatopsia (HP:0007641)1.81615185
89Abnormality of the ischium (HP:0003174)1.80314352
90Congenital sensorineural hearing impairment (HP:0008527)1.80189396
91Decreased central vision (HP:0007663)1.79143519
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.79075527
93Acute lymphatic leukemia (HP:0006721)1.78421607
94Congenital primary aphakia (HP:0007707)1.77269186
95Gait imbalance (HP:0002141)1.76592498
96Type I diabetes mellitus (HP:0100651)1.76353100
97Osteomalacia (HP:0002749)1.75852248
98Tubulointerstitial fibrosis (HP:0005576)1.72021276
99Insulin-resistant diabetes mellitus (HP:0000831)1.71051159
100Gonadotropin excess (HP:0000837)1.70262771
101Pancreatic fibrosis (HP:0100732)1.69575786
102Postaxial foot polydactyly (HP:0001830)1.69220833
103Gaze-evoked nystagmus (HP:0000640)1.69176082
104Asymmetric septal hypertrophy (HP:0001670)1.69000966
105Spastic tetraparesis (HP:0001285)1.68274325
106Aplasia/Hypoplasia of the lens (HP:0008063)1.66828450
107Abnormality of chloride homeostasis (HP:0011422)1.66568430
108Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62615012
109Abnormal drinking behavior (HP:0030082)1.61411752
110Polydipsia (HP:0001959)1.61411752
111Abnormality of renal excretion (HP:0011036)1.58790251
112Heterotopia (HP:0002282)1.58609048
113Choroideremia (HP:0001139)1.55079963
114Congenital hepatic fibrosis (HP:0002612)1.54227394
115Stage 5 chronic kidney disease (HP:0003774)1.53501702
116Bile duct proliferation (HP:0001408)1.51503049
117Abnormal biliary tract physiology (HP:0012439)1.51503049
118Abnormality of permanent molar morphology (HP:0011071)1.50491689
119Abnormality of the dental root (HP:0006486)1.50491689
120Taurodontia (HP:0000679)1.50491689
121Tongue fasciculations (HP:0001308)1.50329126
122Optic nerve hypoplasia (HP:0000609)1.49056766
123Nephrogenic diabetes insipidus (HP:0009806)1.48454077
124Facial cleft (HP:0002006)1.45786411
125Chronic sinusitis (HP:0011109)1.45781231
126Fatigable weakness (HP:0003473)1.45587813
127Abnormality of the neuromuscular junction (HP:0003398)1.45587813
128Oculomotor apraxia (HP:0000657)1.44158950
129Postaxial hand polydactyly (HP:0001162)1.44125274
130Easy fatigability (HP:0003388)1.43197669
131Type 2 muscle fiber atrophy (HP:0003554)1.42986702
132Poor coordination (HP:0002370)1.42187274
133Constricted visual fields (HP:0001133)1.39633930
134Abnormality of saccadic eye movements (HP:0000570)1.39533476
135Genital tract atresia (HP:0001827)1.39399413
136Abnormality of the dental pulp (HP:0006479)1.39141752
137Muscle fibrillation (HP:0010546)1.39105466
138Abnormality of molar (HP:0011077)1.38990835
139Abnormality of molar morphology (HP:0011070)1.38990835
140Vaginal atresia (HP:0000148)1.38915550
141Sensory axonal neuropathy (HP:0003390)1.38023111
142Abnormality of the renal cortex (HP:0011035)1.37589928
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.37165584
144Hemorrhage of the eye (HP:0011885)1.37103476
145Short ribs (HP:0000773)1.33771598
146Cystic liver disease (HP:0006706)1.33725920
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.31687757
148Microglossia (HP:0000171)1.29231085
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.29168376
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27028020
151Supernumerary spleens (HP:0009799)1.27004666
152Impaired smooth pursuit (HP:0007772)1.25893176
153Abnormality of ocular smooth pursuit (HP:0000617)1.25478347
154Bell-shaped thorax (HP:0001591)1.24878679
155Renal dysplasia (HP:0000110)1.24331310
156True hermaphroditism (HP:0010459)1.24304610
157Abnormal urine output (HP:0012590)1.23472806
158Neurofibrillary tangles (HP:0002185)1.23286961
159Pancreatic cysts (HP:0001737)1.21988192
160Cerebellar dysplasia (HP:0007033)1.19786189
161Muscle fiber atrophy (HP:0100295)1.17870676
162Decreased muscle mass (HP:0003199)1.17094964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.99031761
2PDK48.99031761
3PDK25.86492944
4TESK15.08739384
5PRKD33.81310484
6ICK3.62076575
7FLT33.51723537
8MAP4K23.08152945
9INSRR3.03181230
10PLK22.82729880
11FRK2.07975255
12BRD42.02550924
13STK381.92045570
14KIT1.89895385
15PTK2B1.83726819
16DDR21.79600280
17BLK1.78998702
18ADRBK21.75856720
19TNIK1.75410435
20STK391.74802375
21NEK21.74613988
22WNK41.65649085
23SCYL21.54062835
24BMPR1B1.48456817
25GRK11.47704857
26WNK31.32279376
27STK38L1.30817269
28PIK3CG1.29144280
29PNCK1.26590306
30PDK11.23235611
31DYRK1B1.18392163
32DYRK31.18381031
33MKNK21.02801250
34CSF1R0.99905005
35MST1R0.97423176
36STK30.91129686
37MST40.86729960
38PAK30.86414786
39WEE10.85145669
40IRAK10.83974521
41CHEK20.83429071
42EIF2AK30.82688741
43CASK0.82232366
44PKN10.81991244
45PBK0.81507001
46LATS10.81027838
47CDK70.79836057
48BCR0.79526835
49MKNK10.78649328
50ZAK0.78113439
51TTK0.77262726
52PLK40.76856041
53IKBKE0.75120340
54TRIM280.74178776
55PDPK10.73555457
56CCNB10.72872801
57NLK0.72094895
58FER0.70627357
59LMTK20.70377242
60RIPK40.69108248
61TYRO30.68860327
62BRSK20.65448548
63LATS20.62058735
64EPHA40.61856429
65CAMK10.59597954
66NTRK30.59472579
67MUSK0.58959128
68OXSR10.53435489
69MAP2K60.50311774
70MAPK130.49605703
71PINK10.48336543
72NUAK10.48089432
73AKT30.48032530
74PRKAA20.47781018
75PASK0.47546677
76WNK10.47317055
77EIF2AK10.46670866
78CHEK10.46485525
79EEF2K0.45104886
80TESK20.43682662
81MARK10.43498044
82PRKCE0.42034090
83MAP3K10.40440859
84VRK10.39221013
85PAK10.38376435
86IRAK20.38191850
87MAPK150.37949326
88MAP2K20.37814163
89TAOK30.37751367
90PLK10.36733947
91CDC70.34759799
92PRKCG0.34334251
93BRSK10.32187888
94PRKCB0.29983219
95KSR20.29893343
96PRKACB0.29267619
97NTRK20.28991844
98ERBB30.27953924
99MARK30.27574725
100PRKACA0.27097878
101ATM0.27045170
102MAPK10.26714032
103TIE10.26499054
104PHKG10.24704840
105PHKG20.24704840
106MAP2K10.23939845
107PRKAA10.23797339
108DAPK20.23074036
109BRAF0.20410356
110BUB10.20361650
111MAPKAPK50.18801230
112ATR0.18225598
113CAMK1G0.18103821
114PAK20.17921575
115PRKCZ0.17121072
116MARK20.16148006
117AURKA0.14148447
118CDK150.14137263
119MTOR0.13745657
120CDK40.13608334
121MAP3K50.12642207
122NEK60.11872384
123ACVR1B0.11522199
124CDK180.10906808
125CDK11A0.10754527
126CSNK2A10.10145341
127CDK20.09806893
128AURKB0.09288015
129PAK60.09093240
130MAP3K100.08802042
131STK100.08285860
132CDK10.07174255
133CDK60.07123308
134GSK3B0.06974432
135PRKCQ0.06866397
136PIM10.06835323
137CAMKK10.06787902
138CDK140.06730733
139CDK30.06360562
140PRKG20.06107705
141PDGFRB0.05845308
142CSNK2A20.05683596
143TAOK10.05181861
144ZAP700.04508467
145DYRK20.04009122
146STK110.03872728
147RPS6KB10.03481680
148RPS6KA10.03022241
149MELK0.02880431
150CDK120.02016808
151PAK40.01680707
152CAMK2A0.01666664
153MAPK100.01501466
154PLK30.00787116
155MAP3K60.00687638
156MAP3K40.00657443
157GSK3A0.00607375
158MAP2K70.00593437
159PRKG10.00574347

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.14620216
2Vitamin B6 metabolism_Homo sapiens_hsa007504.65840617
3Fatty acid biosynthesis_Homo sapiens_hsa000614.15660914
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.13113138
5Olfactory transduction_Homo sapiens_hsa047403.61727483
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10471846
7Linoleic acid metabolism_Homo sapiens_hsa005913.09401695
8Phototransduction_Homo sapiens_hsa047443.08780013
9Basal transcription factors_Homo sapiens_hsa030223.04780751
10Pyruvate metabolism_Homo sapiens_hsa006203.02642389
11Butanoate metabolism_Homo sapiens_hsa006502.77397097
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65048172
13Glucagon signaling pathway_Homo sapiens_hsa049222.45114493
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14783810
15Propanoate metabolism_Homo sapiens_hsa006402.14321523
16Pentose phosphate pathway_Homo sapiens_hsa000302.11542367
17Oocyte meiosis_Homo sapiens_hsa041142.08884575
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.99304089
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94986802
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.87989181
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81837268
22Glycerolipid metabolism_Homo sapiens_hsa005611.81668215
23Selenocompound metabolism_Homo sapiens_hsa004501.81225894
24Mineral absorption_Homo sapiens_hsa049781.71147903
25Nitrogen metabolism_Homo sapiens_hsa009101.67843617
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64651846
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63609567
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61017981
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59888795
30Fanconi anemia pathway_Homo sapiens_hsa034601.54734957
31Ether lipid metabolism_Homo sapiens_hsa005651.54032920
32Nicotine addiction_Homo sapiens_hsa050331.50529442
33PPAR signaling pathway_Homo sapiens_hsa033201.50336866
34One carbon pool by folate_Homo sapiens_hsa006701.47138721
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43879155
36Purine metabolism_Homo sapiens_hsa002301.41063645
37Fat digestion and absorption_Homo sapiens_hsa049751.40134977
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39803062
39Caffeine metabolism_Homo sapiens_hsa002321.38875610
40Carbon metabolism_Homo sapiens_hsa012001.37759996
41RNA transport_Homo sapiens_hsa030131.36175695
42Amphetamine addiction_Homo sapiens_hsa050311.35219841
43Fructose and mannose metabolism_Homo sapiens_hsa000511.33015651
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19456502
45Cardiac muscle contraction_Homo sapiens_hsa042601.17052331
46Glutathione metabolism_Homo sapiens_hsa004801.16946236
47Non-homologous end-joining_Homo sapiens_hsa034501.16219659
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14857184
49mRNA surveillance pathway_Homo sapiens_hsa030151.14690393
50Long-term depression_Homo sapiens_hsa047301.13611344
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13362867
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.08588706
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05236054
54Dorso-ventral axis formation_Homo sapiens_hsa043201.04812737
55Biosynthesis of amino acids_Homo sapiens_hsa012301.04180405
56Collecting duct acid secretion_Homo sapiens_hsa049661.01394175
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.99122439
58Fatty acid metabolism_Homo sapiens_hsa012120.98639626
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97080257
60Fatty acid degradation_Homo sapiens_hsa000710.95387407
61Antigen processing and presentation_Homo sapiens_hsa046120.94478963
62Hedgehog signaling pathway_Homo sapiens_hsa043400.93444070
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91464895
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90928104
65Morphine addiction_Homo sapiens_hsa050320.90700098
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89430464
67Huntingtons disease_Homo sapiens_hsa050160.88787754
68Protein export_Homo sapiens_hsa030600.84520619
69Arachidonic acid metabolism_Homo sapiens_hsa005900.83697071
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81653150
71Folate biosynthesis_Homo sapiens_hsa007900.80338468
72Tyrosine metabolism_Homo sapiens_hsa003500.79042938
73Renin secretion_Homo sapiens_hsa049240.78607734
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78220109
75Pyrimidine metabolism_Homo sapiens_hsa002400.77585684
76Serotonergic synapse_Homo sapiens_hsa047260.77343985
77Inositol phosphate metabolism_Homo sapiens_hsa005620.74684578
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72281377
79Chemical carcinogenesis_Homo sapiens_hsa052040.70920920
80N-Glycan biosynthesis_Homo sapiens_hsa005100.70188044
81Insulin secretion_Homo sapiens_hsa049110.70154934
82Type I diabetes mellitus_Homo sapiens_hsa049400.68511773
83Long-term potentiation_Homo sapiens_hsa047200.67939981
84Base excision repair_Homo sapiens_hsa034100.67651755
85Estrogen signaling pathway_Homo sapiens_hsa049150.66824467
86Thyroid hormone synthesis_Homo sapiens_hsa049180.65969120
87Cell cycle_Homo sapiens_hsa041100.65920576
88Renin-angiotensin system_Homo sapiens_hsa046140.65316854
89Bile secretion_Homo sapiens_hsa049760.64769329
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64455283
91Systemic lupus erythematosus_Homo sapiens_hsa053220.63650701
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.63293396
93Phenylalanine metabolism_Homo sapiens_hsa003600.59037401
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58714996
95Glutamatergic synapse_Homo sapiens_hsa047240.58575148
96Regulation of autophagy_Homo sapiens_hsa041400.56771646
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55893454
98Retinol metabolism_Homo sapiens_hsa008300.55832470
99Pancreatic secretion_Homo sapiens_hsa049720.55787339
100Mismatch repair_Homo sapiens_hsa034300.55554219
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.55194683
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55183970
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53254961
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52416022
105Arginine and proline metabolism_Homo sapiens_hsa003300.51820444
106beta-Alanine metabolism_Homo sapiens_hsa004100.50525388
107RNA polymerase_Homo sapiens_hsa030200.49982849
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49691758
109Steroid biosynthesis_Homo sapiens_hsa001000.48860622
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.48634500
111GABAergic synapse_Homo sapiens_hsa047270.47249782
112Salivary secretion_Homo sapiens_hsa049700.46608750
113Metabolic pathways_Homo sapiens_hsa011000.46540694
114Calcium signaling pathway_Homo sapiens_hsa040200.44633256
115Nucleotide excision repair_Homo sapiens_hsa034200.44336542
116Synaptic vesicle cycle_Homo sapiens_hsa047210.43000224
117AMPK signaling pathway_Homo sapiens_hsa041520.42133864
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.40444685
119Endocytosis_Homo sapiens_hsa041440.40280928
120Protein digestion and absorption_Homo sapiens_hsa049740.40165955
121Allograft rejection_Homo sapiens_hsa053300.39688890
122Autoimmune thyroid disease_Homo sapiens_hsa053200.39075398
123Gap junction_Homo sapiens_hsa045400.38207619
124Type II diabetes mellitus_Homo sapiens_hsa049300.36973199
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.36577511
126Legionellosis_Homo sapiens_hsa051340.36330130
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36021171
128Sulfur metabolism_Homo sapiens_hsa009200.34686489
129Gastric acid secretion_Homo sapiens_hsa049710.34013923
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31131655
131Tryptophan metabolism_Homo sapiens_hsa003800.30401781
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29409641
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29179588
134cAMP signaling pathway_Homo sapiens_hsa040240.28251179
135Oxytocin signaling pathway_Homo sapiens_hsa049210.28202564
136Graft-versus-host disease_Homo sapiens_hsa053320.27655419
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26804818
138Taste transduction_Homo sapiens_hsa047420.24753614
139RNA degradation_Homo sapiens_hsa030180.24741728
140VEGF signaling pathway_Homo sapiens_hsa043700.23106452
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21470119
142Alcoholism_Homo sapiens_hsa050340.20745730
143ABC transporters_Homo sapiens_hsa020100.19231345
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16676461
145Wnt signaling pathway_Homo sapiens_hsa043100.13941192
146Epstein-Barr virus infection_Homo sapiens_hsa051690.12965004
147DNA replication_Homo sapiens_hsa030300.11734448
148Homologous recombination_Homo sapiens_hsa034400.11445995
149Circadian entrainment_Homo sapiens_hsa047130.09682938
150HIF-1 signaling pathway_Homo sapiens_hsa040660.09620535
151Vitamin digestion and absorption_Homo sapiens_hsa049770.09097578

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