IQCF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.99316351
2epithelial cilium movement (GO:0003351)9.90706962
3axonemal dynein complex assembly (GO:0070286)9.68883255
4reproduction (GO:0000003)9.54197082
5motile cilium assembly (GO:0044458)9.29892453
6regulation of cilium movement (GO:0003352)8.86745290
7cilium or flagellum-dependent cell motility (GO:0001539)8.79009960
8cilium movement (GO:0003341)7.99279256
9negative regulation of inclusion body assembly (GO:0090084)7.57450036
10single fertilization (GO:0007338)7.54233053
11sperm capacitation (GO:0048240)7.44466105
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.35938261
13synaptonemal complex organization (GO:0070193)6.95489669
14spermatogenesis (GO:0007283)6.90977875
15male gamete generation (GO:0048232)6.88519346
16male meiosis (GO:0007140)6.84173373
17synaptonemal complex assembly (GO:0007130)6.79439358
18organic cation transport (GO:0015695)6.74756030
19microtubule depolymerization (GO:0007019)6.74103591
20piRNA metabolic process (GO:0034587)6.61440650
21fertilization (GO:0009566)6.38788733
22gamete generation (GO:0007276)6.33001036
23regulation of inclusion body assembly (GO:0090083)6.22647202
24calcium ion-dependent exocytosis (GO:0017156)5.76680060
25chromosome condensation (GO:0030261)5.56757407
26germ cell development (GO:0007281)5.52394665
27spermatid nucleus differentiation (GO:0007289)5.46724979
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.41871825
29regulation of memory T cell differentiation (GO:0043380)5.35791268
30glycerol ether metabolic process (GO:0006662)5.33980724
31DNA packaging (GO:0006323)5.25203230
32regulation of microtubule-based movement (GO:0060632)5.24758317
33indole-containing compound catabolic process (GO:0042436)5.21050548
34indolalkylamine catabolic process (GO:0046218)5.21050548
35tryptophan catabolic process (GO:0006569)5.21050548
36ventricular system development (GO:0021591)5.14855622
37cell recognition (GO:0008037)5.04035283
38multicellular organismal reproductive process (GO:0048609)4.98902081
39ether metabolic process (GO:0018904)4.93564307
40kynurenine metabolic process (GO:0070189)4.83871483
41male meiosis I (GO:0007141)4.76175649
42negative regulation of multicellular organism growth (GO:0040015)4.71137208
43microtubule severing (GO:0051013)4.70136008
44chromosome organization involved in meiosis (GO:0070192)4.65275593
45sexual reproduction (GO:0019953)4.65103816
46seminiferous tubule development (GO:0072520)4.60538858
47indolalkylamine metabolic process (GO:0006586)4.50371742
48regulation of establishment of cell polarity (GO:2000114)4.49405829
49single strand break repair (GO:0000012)4.45645572
50tryptophan metabolic process (GO:0006568)4.39499102
51cytoplasmic mRNA processing body assembly (GO:0033962)4.34982323
52DNA methylation involved in gamete generation (GO:0043046)4.25664592
53neural tube formation (GO:0001841)4.25173943
54left/right pattern formation (GO:0060972)4.24919141
55chaperone-mediated protein complex assembly (GO:0051131)4.20206397
56sex differentiation (GO:0007548)4.18820738
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.11296407
58regulation of MHC class I biosynthetic process (GO:0045343)4.10389610
59meiotic nuclear division (GO:0007126)4.06602232
60multicellular organismal development (GO:0007275)4.01198384
61cellular ketone body metabolic process (GO:0046950)3.98898725
62response to pheromone (GO:0019236)3.84773500
63detection of light stimulus involved in sensory perception (GO:0050962)3.80945573
64detection of light stimulus involved in visual perception (GO:0050908)3.80945573
65meiosis I (GO:0007127)3.77333128
66fucose catabolic process (GO:0019317)3.75458464
67L-fucose metabolic process (GO:0042354)3.75458464
68L-fucose catabolic process (GO:0042355)3.75458464
69regulation of establishment or maintenance of cell polarity (GO:0032878)3.74193075
70establishment of protein localization to Golgi (GO:0072600)3.65822886
71ketone body metabolic process (GO:1902224)3.62887777
72genitalia morphogenesis (GO:0035112)3.53238334
73microtubule polymerization or depolymerization (GO:0031109)3.51196633
74protein polyglutamylation (GO:0018095)3.46656243
75sequestering of actin monomers (GO:0042989)3.44629789
76protein refolding (GO:0042026)3.41699537
77amine catabolic process (GO:0009310)3.38786986
78cellular biogenic amine catabolic process (GO:0042402)3.38786986
79protein K11-linked deubiquitination (GO:0035871)3.36893126
80photoreceptor cell maintenance (GO:0045494)3.35890806
81regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.35064000
82positive regulation of vasculogenesis (GO:2001214)3.34150049
83regulation of spindle checkpoint (GO:0090231)3.33073165
84glycolytic process (GO:0006096)3.31003514
85nucleus organization (GO:0006997)3.22136221
86reflex (GO:0060004)3.21539647
87meiotic cell cycle (GO:0051321)3.21297019
88nucleoside diphosphate catabolic process (GO:0009134)3.21100441
89ADP metabolic process (GO:0046031)3.20229814
90aromatic amino acid family catabolic process (GO:0009074)3.17542331
91indole-containing compound metabolic process (GO:0042430)3.15595954
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13595733
93monoubiquitinated protein deubiquitination (GO:0035520)3.13416870
94signal peptide processing (GO:0006465)3.13345048
95nucleoside diphosphate phosphorylation (GO:0006165)3.12878098
96sterol catabolic process (GO:0016127)3.10251774
97cholesterol catabolic process (GO:0006707)3.10251774
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07910220
99protein targeting to Golgi (GO:0000042)3.05608808
100mitotic sister chromatid cohesion (GO:0007064)3.02869431
101regulation of action potential (GO:0098900)3.02794366
102amino-acid betaine transport (GO:0015838)3.00843893
103carnitine transport (GO:0015879)3.00843893
104behavioral response to ethanol (GO:0048149)2.97732201
105auditory receptor cell stereocilium organization (GO:0060088)2.96109983
106DNA double-strand break processing (GO:0000729)2.95912659
107polyol catabolic process (GO:0046174)2.95299196
108polyamine biosynthetic process (GO:0006596)2.95021695
109NAD biosynthetic process (GO:0009435)2.94908463
110protein localization to cilium (GO:0061512)2.94672636
111central nervous system neuron axonogenesis (GO:0021955)2.93307078
112RNA localization (GO:0006403)2.91560879
113GTP biosynthetic process (GO:0006183)2.91388905
114centrosome duplication (GO:0051298)2.90965454
115alditol metabolic process (GO:0019400)2.90943051
116regulation of meiosis I (GO:0060631)2.90923064
117centriole replication (GO:0007099)2.87430946
118positive regulation of macrophage activation (GO:0043032)2.86121966
119benzene-containing compound metabolic process (GO:0042537)2.85028735
120interferon-gamma secretion (GO:0072643)2.83986969
121RNA destabilization (GO:0050779)2.83921378
122neuronal action potential propagation (GO:0019227)2.82076706
123synapsis (GO:0007129)2.81943567
124carnitine transmembrane transport (GO:1902603)2.80344655
125inner ear receptor stereocilium organization (GO:0060122)2.78855517
126somite rostral/caudal axis specification (GO:0032525)2.78716794
127cerebellar Purkinje cell differentiation (GO:0021702)2.78485217
128cilium organization (GO:0044782)2.78076469
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78023141
130negative regulation of mast cell activation (GO:0033004)2.77934565
131chromatin silencing (GO:0006342)2.76687650
132retinal cone cell development (GO:0046549)2.76670499
133regulation of vasculogenesis (GO:2001212)2.75436997
134platelet dense granule organization (GO:0060155)2.74383480
135righting reflex (GO:0060013)2.73831849
136gamma-aminobutyric acid transport (GO:0015812)2.72432193
137meiotic cell cycle process (GO:1903046)2.71472393
138lipid particle organization (GO:0034389)2.70513624
139tachykinin receptor signaling pathway (GO:0007217)2.69479883
140dopamine transport (GO:0015872)2.68381324
141microtubule-based movement (GO:0007018)2.68281990
142regulation of glucokinase activity (GO:0033131)2.67793148
143regulation of hexokinase activity (GO:1903299)2.67793148
144cilium assembly (GO:0042384)2.67195679
145sphingoid metabolic process (GO:0046519)2.66735360
146mitochondrion degradation (GO:0000422)2.66415213
147regulation of hippo signaling (GO:0035330)2.66335592
148regulation of sarcomere organization (GO:0060297)2.66291186
149behavioral response to nicotine (GO:0035095)2.65062298
150regulation of cilium assembly (GO:1902017)2.64845705
151cellular component assembly involved in morphogenesis (GO:0010927)2.64486730
152aromatic amino acid family metabolic process (GO:0009072)2.64471448
153bile acid biosynthetic process (GO:0006699)2.64298234
154protein localization to Golgi apparatus (GO:0034067)2.62957084
155nonmotile primary cilium assembly (GO:0035058)2.61579867
156detection of mechanical stimulus involved in sensory perception (GO:0050974)2.61102474
157negative regulation of translation, ncRNA-mediated (GO:0040033)2.61095233
158regulation of translation, ncRNA-mediated (GO:0045974)2.61095233
159negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61095233
160phosphatidylethanolamine metabolic process (GO:0046337)2.60424464
161lactate metabolic process (GO:0006089)2.59888740
162UTP biosynthetic process (GO:0006228)2.59759638
163regulation of collateral sprouting (GO:0048670)2.59717482
164cilium morphogenesis (GO:0060271)2.56460097
165intraciliary transport (GO:0042073)2.53618953
166positive regulation of glycolytic process (GO:0045821)2.53062505
167axoneme assembly (GO:0035082)2.51405118
168negative regulation of organelle assembly (GO:1902116)2.44317020
169centriole assembly (GO:0098534)2.39571940
170sperm motility (GO:0030317)14.6290571
171fusion of sperm to egg plasma membrane (GO:0007342)13.4250665
172cell wall macromolecule catabolic process (GO:0016998)12.8575725
173cell wall macromolecule metabolic process (GO:0044036)12.8575725
174acrosome reaction (GO:0007340)12.6114753
175sperm-egg recognition (GO:0035036)11.6163567
176acrosome assembly (GO:0001675)11.5162504
177multicellular organism reproduction (GO:0032504)10.9393801
178binding of sperm to zona pellucida (GO:0007339)10.5328221
179cell-cell recognition (GO:0009988)10.3960957
180plasma membrane fusion (GO:0045026)10.2338457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.79035854
2EZH2_22144423_ChIP-Seq_EOC_Human4.19495233
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92126630
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37977666
5GBX2_23144817_ChIP-Seq_PC3_Human3.35651172
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.25755855
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88023697
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81396977
9VDR_22108803_ChIP-Seq_LS180_Human2.66371182
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59050889
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58003221
12IGF1R_20145208_ChIP-Seq_DFB_Human2.53676308
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40916057
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32006441
15FUS_26573619_Chip-Seq_HEK293_Human2.25421118
16P300_19829295_ChIP-Seq_ESCs_Human2.23511115
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.19391995
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18273375
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15473152
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.15253887
21ER_23166858_ChIP-Seq_MCF-7_Human2.11997772
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07131292
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06549440
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00141446
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.97895037
26ZNF274_21170338_ChIP-Seq_K562_Hela1.97810120
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96419892
28BCAT_22108803_ChIP-Seq_LS180_Human1.94150339
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.86929158
30SMAD4_21799915_ChIP-Seq_A2780_Human1.83096756
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80617985
32EWS_26573619_Chip-Seq_HEK293_Human1.80310060
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79822586
34STAT3_23295773_ChIP-Seq_U87_Human1.79702217
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73837516
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73631729
37STAT1_17558387_ChIP-Seq_HELA_Human1.72956759
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72746268
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72286731
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70225337
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68265695
42AR_25329375_ChIP-Seq_VCAP_Human1.67281995
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66332175
44TCF4_23295773_ChIP-Seq_U87_Human1.64231710
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.60364812
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58010548
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.55323982
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53430639
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.52823435
50KDM2B_26808549_Chip-Seq_REH_Human1.50783372
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.50471367
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50005744
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.47138883
54TCF4_22108803_ChIP-Seq_LS180_Human1.45953974
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45702475
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44387299
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44185105
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43393495
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42932562
60FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41159438
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37437574
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36841481
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.36662055
64P53_21459846_ChIP-Seq_SAOS-2_Human1.36162126
65RUNX2_22187159_ChIP-Seq_PCA_Human1.35855391
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.35854442
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35551893
68CDX2_22108803_ChIP-Seq_LS180_Human1.34754188
69LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34113681
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.29638561
71* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28743775
72* CBP_20019798_ChIP-Seq_JUKART_Human1.28743775
73TAF15_26573619_Chip-Seq_HEK293_Human1.28205021
74SOX2_19829295_ChIP-Seq_ESCs_Human1.27596460
75NANOG_19829295_ChIP-Seq_ESCs_Human1.27596460
76* REST_21632747_ChIP-Seq_MESCs_Mouse1.27198534
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26717982
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.26032577
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.26006450
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25901664
81RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24897877
82GF1_26923725_Chip-Seq_HPCs_Mouse1.24741508
83* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24264643
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23976116
85AR_21572438_ChIP-Seq_LNCaP_Human1.22769638
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.22398066
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22144860
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21955626
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21153237
90TP53_22573176_ChIP-Seq_HFKS_Human1.21093345
91CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20711384
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20681570
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20232487
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20232487
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.19802726
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19106384
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16022721
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15336753
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15298707
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14026514
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13197432
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.13197432
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.13085798
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12993626
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12685798
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10411711
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10254659
108ERG_20517297_ChIP-Seq_VCAP_Human1.09724979
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09022833
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08640492
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.07699225
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.07670463
113* SPI1_26923725_Chip-Seq_HPCs_Mouse1.07659928
114* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07501096
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06573695
116RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06309964
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05523549
118MYC_27129775_Chip-Seq_CORNEA_Mouse1.05135305
119ESET_19884257_ChIP-Seq_ESCs_Mouse1.05081778
120TP53_18474530_ChIP-ChIP_U2OS_Human1.05001567
121TBL1_22424771_ChIP-Seq_293T_Human1.04618000
122GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04497517
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.04077471
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.03428910
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03178646
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02395506
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02344364
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.01965332
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01914415
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01232333
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01181820
132IRF1_19129219_ChIP-ChIP_H3396_Human1.00883054
133AHR_22903824_ChIP-Seq_MCF-7_Human1.00689327
134YY1_22570637_ChIP-Seq_MALME-3M_Human1.00494051
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00277626
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.99501696
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99089253
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99038893
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.98421164
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98365501
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98208034
142CTCF_20526341_ChIP-Seq_ESCs_Human0.97265022
143* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96878765
144P53_22387025_ChIP-Seq_ESCs_Mouse0.96455729
145SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95895331
146NFYB_21822215_ChIP-Seq_K562_Human0.94337986
147LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94217600
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.94035902
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93954406
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92258506
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90854880
152NANOG_20526341_ChIP-Seq_ESCs_Human0.90793172
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90510753
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90501154
155P300_18555785_Chip-Seq_ESCs_Mouse0.89484305
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.88711009
157SOX9_26525672_Chip-Seq_HEART_Mouse0.88611661
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88215081
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.88133570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11502272
2MP0001929_abnormal_gametogenesis5.53673726
3MP0008877_abnormal_DNA_methylation3.89588251
4MP0003195_calcinosis3.53057892
5MP0002161_abnormal_fertility/fecundity3.34377693
6MP0002210_abnormal_sex_determination3.31555525
7MP0005670_abnormal_white_adipose3.14990108
8MP0003252_abnormal_bile_duct2.83825987
9MP0001145_abnormal_male_reproductive2.79642265
10MP0002837_dystrophic_cardiac_calcinosis2.53983039
11MP0005646_abnormal_pituitary_gland2.50327054
12MP0000653_abnormal_sex_gland2.42115182
13MP0002653_abnormal_ependyma_morphology2.14313305
14MP0005410_abnormal_fertilization16.7555015
15MP0001501_abnormal_sleep_pattern1.98293077
16MP0009745_abnormal_behavioral_response1.90368973
17MP0006072_abnormal_retinal_apoptosis1.83664911
18MP0001986_abnormal_taste_sensitivity1.82390628
19MP0001486_abnormal_startle_reflex1.74866519
20MP0000427_abnormal_hair_cycle1.73219894
21MP0003718_maternal_effect1.65157299
22MP0000372_irregular_coat_pigmentation1.58462285
23MP0002876_abnormal_thyroid_physiology1.57821372
24MP0008057_abnormal_DNA_replication1.56745611
25MP0005174_abnormal_tail_pigmentation1.56045843
26MP0003880_abnormal_central_pattern1.52864356
27MP0002938_white_spotting1.47062900
28MP0002163_abnormal_gland_morphology1.46605947
29MP0002160_abnormal_reproductive_system1.43526200
30MP0005379_endocrine/exocrine_gland_phen1.43435775
31MP0000371_diluted_coat_color1.42769663
32MP0002272_abnormal_nervous_system1.42521669
33MP0008872_abnormal_physiological_respon1.41257934
34MP0004147_increased_porphyrin_level1.39639212
35MP0005623_abnormal_meninges_morphology1.38701608
36MP0005171_absent_coat_pigmentation1.37490609
37MP0001485_abnormal_pinna_reflex1.34998571
38MP0003137_abnormal_impulse_conducting1.34861738
39MP0005075_abnormal_melanosome_morpholog1.34446909
40MP0000631_abnormal_neuroendocrine_gland1.32398321
41MP0003646_muscle_fatigue1.31575562
42MP0004233_abnormal_muscle_weight1.31042178
43MP0002138_abnormal_hepatobiliary_system1.23952894
44MP0005645_abnormal_hypothalamus_physiol1.23319348
45MP0000516_abnormal_urinary_system1.23019449
46MP0005367_renal/urinary_system_phenotyp1.23019449
47MP0002638_abnormal_pupillary_reflex1.22079155
48MP0004142_abnormal_muscle_tone1.20287960
49MP0002064_seizures1.18674920
50MP0006292_abnormal_olfactory_placode1.18134619
51MP0001765_abnormal_ion_homeostasis1.15917948
52MP0002282_abnormal_trachea_morphology1.15262992
53MP0005386_behavior/neurological_phenoty1.14877811
54MP0004924_abnormal_behavior1.14877811
55MP0004215_abnormal_myocardial_fiber1.10742016
56MP0005395_other_phenotype1.09495779
57MP0000015_abnormal_ear_pigmentation1.08221377
58MP0002067_abnormal_sensory_capabilities1.07078355
59MP0000383_abnormal_hair_follicle1.06493653
60MP0002572_abnormal_emotion/affect_behav1.06244900
61MP0009697_abnormal_copulation1.03623880
62MP0002751_abnormal_autonomic_nervous1.03375031
63MP0001529_abnormal_vocalization1.02185705
64MP0006054_spinal_hemorrhage1.01768625
65MP0003136_yellow_coat_color1.01627730
66MP0002735_abnormal_chemical_nociception0.98545134
67MP0001984_abnormal_olfaction0.97575542
68MP0008995_early_reproductive_senescence0.95460616
69MP0001970_abnormal_pain_threshold0.94551317
70MP0006276_abnormal_autonomic_nervous0.93562168
71MP0005310_abnormal_salivary_gland0.92303869
72MP0002557_abnormal_social/conspecific_i0.91645735
73MP0005647_abnormal_sex_gland0.91441917
74MP0002733_abnormal_thermal_nociception0.90435635
75MP0002168_other_aberrant_phenotype0.89847712
76MP0002234_abnormal_pharynx_morphology0.89664562
77MP0002254_reproductive_system_inflammat0.86953793
78MP0010386_abnormal_urinary_bladder0.81890106
79MP0008058_abnormal_DNA_repair0.81479927
80MP0003121_genomic_imprinting0.81342884
81MP0002095_abnormal_skin_pigmentation0.79383705
82MP0003635_abnormal_synaptic_transmissio0.79342309
83MP0008875_abnormal_xenobiotic_pharmacok0.79056625
84MP0003943_abnormal_hepatobiliary_system0.77707853
85MP0005085_abnormal_gallbladder_physiolo0.76903421
86MP0003878_abnormal_ear_physiology0.75605701
87MP0005377_hearing/vestibular/ear_phenot0.75605701
88MP0009046_muscle_twitch0.75214347
89MP0003119_abnormal_digestive_system0.75203342
90MP0003937_abnormal_limbs/digits/tail_de0.75106474
91MP0005389_reproductive_system_phenotype0.74500313
92MP0003115_abnormal_respiratory_system0.71200295
93MP0005636_abnormal_mineral_homeostasis0.65574701
94MP0005666_abnormal_adipose_tissue0.65432418
95MP0003011_delayed_dark_adaptation0.56118789
96MP0001764_abnormal_homeostasis0.55590224
97MP0003329_amyloid_beta_deposits0.54707035
98MP0001324_abnormal_eye_pigmentation0.51694803
99MP0002736_abnormal_nociception_after0.48710855
100MP0000569_abnormal_digit_pigmentation0.48542718
101MP0003699_abnormal_female_reproductive0.46984643
102MP0004036_abnormal_muscle_relaxation0.46648057
103MP0001293_anophthalmia0.44130509
104MP0000358_abnormal_cell_content/0.43148875
105MP0002269_muscular_atrophy0.41870321
106MP0005253_abnormal_eye_physiology0.39440338
107MP0009115_abnormal_fat_cell0.39108257
108MP0000534_abnormal_ureter_morphology0.39093581
109MP0009278_abnormal_bone_marrow0.38557665
110MP0005551_abnormal_eye_electrophysiolog0.38538944
111MP0010094_abnormal_chromosome_stability0.38242795
112MP0003950_abnormal_plasma_membrane0.37796607
113MP0001545_abnormal_hematopoietic_system0.35128691
114MP0005397_hematopoietic_system_phenotyp0.35128691
115MP0002928_abnormal_bile_duct0.34922595
116MP0006036_abnormal_mitochondrial_physio0.32816704
117MP0003942_abnormal_urinary_system0.31632346
118MP0002971_abnormal_brown_adipose0.31255362
119MP0003111_abnormal_nucleus_morphology0.29608499
120MP0005391_vision/eye_phenotype0.29350802
121MP0004133_heterotaxia0.29270802
122MP0004742_abnormal_vestibular_system0.29020893
123MP0003633_abnormal_nervous_system0.28455271
124MP0000604_amyloidosis0.26623082
125MP0001968_abnormal_touch/_nociception0.26081135
126MP0001119_abnormal_female_reproductive0.26057179
127MP0004811_abnormal_neuron_physiology0.25793522
128MP0003786_premature_aging0.24296411
129MP0003879_abnormal_hair_cell0.24038888
130MP0003948_abnormal_gas_homeostasis0.23136940
131MP0003631_nervous_system_phenotype0.22951117
132MP0004270_analgesia0.22466794
133MP0003861_abnormal_nervous_system0.22013876
134MP0002139_abnormal_hepatobiliary_system0.21930664
135MP0002169_no_abnormal_phenotype0.21621495
136MP0003787_abnormal_imprinting0.21565240
137MP0002873_normal_phenotype0.21425152
138MP0002152_abnormal_brain_morphology0.21374345
139MP0005375_adipose_tissue_phenotype0.20962678
140MP0004019_abnormal_vitamin_homeostasis0.20891892
141MP0001730_embryonic_growth_arrest0.20166499
142MP0002295_abnormal_pulmonary_circulatio0.19940586
143MP0000920_abnormal_myelination0.19389476
144MP0008961_abnormal_basal_metabolism0.19137060
145MP0001727_abnormal_embryo_implantation0.18575544
146MP0002102_abnormal_ear_morphology0.18176907
147MP0000462_abnormal_digestive_system0.17854209
148MP0002229_neurodegeneration0.16641083
149MP0001348_abnormal_lacrimal_gland0.15278586
150MP0006035_abnormal_mitochondrial_morpho0.14513493
151MP0001849_ear_inflammation0.14360266
152MP0002092_abnormal_eye_morphology0.14272011
153MP0008569_lethality_at_weaning0.14106762
154MP0002693_abnormal_pancreas_physiology0.13786150
155MP0000001_mammalian_phenotype0.13584696
156MP0004145_abnormal_muscle_electrophysio0.13269652
157MP0004043_abnormal_pH_regulation0.12820392
158MP0000751_myopathy0.12578800
159MP0002118_abnormal_lipid_homeostasis0.12360464
160MP0001661_extended_life_span0.11633555
161MP0003959_abnormal_lean_body0.11376191
162MP0005195_abnormal_posterior_eye0.11354635
163MP0002405_respiratory_system_inflammati0.11197997
164MP0005535_abnormal_body_temperature0.10744626
165MP0004130_abnormal_muscle_cell0.10692586
166MP0008007_abnormal_cellular_replicative0.10681175

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.40008075
2Abnormal respiratory motile cilium morphology (HP:0005938)9.40008075
3Abnormal respiratory motile cilium physiology (HP:0012261)9.35260748
4Abnormal ciliary motility (HP:0012262)7.49310776
5Rhinitis (HP:0012384)7.34836380
6Chronic bronchitis (HP:0004469)7.15691517
7Infertility (HP:0000789)7.03801830
8Nasal polyposis (HP:0100582)6.31762623
9Genetic anticipation (HP:0003743)5.51790054
10Abnormality of the nasal mucosa (HP:0000433)5.18268934
11Male infertility (HP:0003251)5.16699307
12Progressive cerebellar ataxia (HP:0002073)4.86344883
13Bronchitis (HP:0012387)4.52893230
14Bronchiectasis (HP:0002110)4.38521380
15Gaze-evoked nystagmus (HP:0000640)4.31985393
16Pancreatic cysts (HP:0001737)4.23063038
17Nephronophthisis (HP:0000090)4.09306541
18Abnormality of macular pigmentation (HP:0008002)4.04907372
19Severe visual impairment (HP:0001141)3.97151224
20Abnormal spermatogenesis (HP:0008669)3.83266119
21True hermaphroditism (HP:0010459)3.68572289
22Action tremor (HP:0002345)3.61689336
23Pendular nystagmus (HP:0012043)3.60051529
24Hyperventilation (HP:0002883)3.38743485
25Recurrent sinusitis (HP:0011108)3.36450987
26Congenital stationary night blindness (HP:0007642)3.33871498
27Attenuation of retinal blood vessels (HP:0007843)3.26803712
28Recurrent otitis media (HP:0000403)3.26396764
29Focal seizures (HP:0007359)3.17892085
30Dysmetric saccades (HP:0000641)3.16694179
31Prostate neoplasm (HP:0100787)3.14167664
32Abnormality of the renal medulla (HP:0100957)3.08010897
33Dialeptic seizures (HP:0011146)3.06001578
34Absence seizures (HP:0002121)2.95569155
35Chronic hepatic failure (HP:0100626)2.92301072
36Tubulointerstitial nephritis (HP:0001970)2.87287884
37Focal motor seizures (HP:0011153)2.79772359
38Recurrent bronchitis (HP:0002837)2.77694372
39Impulsivity (HP:0100710)2.72182615
40Bony spicule pigmentary retinopathy (HP:0007737)2.63633579
41Abnormal rod and cone electroretinograms (HP:0008323)2.62789291
42Tubular atrophy (HP:0000092)2.60975023
43Abolished electroretinogram (ERG) (HP:0000550)2.59116271
44Central scotoma (HP:0000603)2.55122915
45Increased corneal curvature (HP:0100692)2.54946929
46Keratoconus (HP:0000563)2.54946929
47Abnormality of the hepatic vasculature (HP:0006707)2.54824956
48Hypoplasia of the fovea (HP:0007750)2.51064265
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.51064265
50Febrile seizures (HP:0002373)2.50022204
51Urinary bladder sphincter dysfunction (HP:0002839)2.49386661
52Abnormal gallbladder physiology (HP:0012438)2.49162739
53Cholecystitis (HP:0001082)2.49162739
54Abnormality of midbrain morphology (HP:0002418)2.48427307
55Molar tooth sign on MRI (HP:0002419)2.48427307
56Tubulointerstitial abnormality (HP:0001969)2.46962821
57Absent speech (HP:0001344)2.39697557
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.34916128
59Intestinal atresia (HP:0011100)2.33206276
60Sclerocornea (HP:0000647)2.32324829
61Medial flaring of the eyebrow (HP:0010747)2.31062375
62Azoospermia (HP:0000027)2.29193913
63Dysdiadochokinesis (HP:0002075)2.28632909
64Congenital sensorineural hearing impairment (HP:0008527)2.24822960
65Gonadotropin excess (HP:0000837)2.23525215
66Abnormality of the fovea (HP:0000493)2.23497345
67Dyschromatopsia (HP:0007641)2.23075749
68Renal cortical cysts (HP:0000803)2.20787535
69Chorioretinal atrophy (HP:0000533)2.12876079
70Retinitis pigmentosa (HP:0000510)2.12670832
71Postural instability (HP:0002172)2.09146628
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.06706057
73Genital tract atresia (HP:0001827)2.05699474
74Choroideremia (HP:0001139)2.04096365
75Type II lissencephaly (HP:0007260)2.03580087
76Impaired vibratory sensation (HP:0002495)2.03285898
77Inability to walk (HP:0002540)2.01919330
78Anencephaly (HP:0002323)2.01113472
79Decreased central vision (HP:0007663)2.00705137
80Tubulointerstitial fibrosis (HP:0005576)2.00031324
81Absent/shortened dynein arms (HP:0200106)13.7035031
82Dynein arm defect of respiratory motile cilia (HP:0012255)13.7035031
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8671800
84Spastic tetraparesis (HP:0001285)1.98082299
85Fair hair (HP:0002286)1.97538381
86Nephrogenic diabetes insipidus (HP:0009806)1.93652553
87Albinism (HP:0001022)1.93121143
88Hypothermia (HP:0002045)1.90942971
89Vaginal atresia (HP:0000148)1.90139746
90Hypochromic microcytic anemia (HP:0004840)1.89559866
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.85124820
92Small hand (HP:0200055)1.85096292
93Male pseudohermaphroditism (HP:0000037)1.84789642
94Progressive inability to walk (HP:0002505)1.84572452
95Scotoma (HP:0000575)1.83837813
96Preaxial hand polydactyly (HP:0001177)1.83572557
97Furrowed tongue (HP:0000221)1.83468555
98Disproportionate short-trunk short stature (HP:0003521)1.83302318
99Atonic seizures (HP:0010819)1.82398509
100Broad-based gait (HP:0002136)1.79276020
101Protruding tongue (HP:0010808)1.78653764
102Aplasia/Hypoplasia of the macula (HP:0008059)1.78631193
103Abnormal drinking behavior (HP:0030082)1.77431038
104Polydipsia (HP:0001959)1.77431038
105Hemorrhage of the eye (HP:0011885)1.76391232
106Stage 5 chronic kidney disease (HP:0003774)1.75494847
107Postaxial foot polydactyly (HP:0001830)1.73540623
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73418483
109Macular degeneration (HP:0000608)1.72040752
110Bile duct proliferation (HP:0001408)1.71463665
111Abnormal biliary tract physiology (HP:0012439)1.71463665
112Astigmatism (HP:0000483)1.70387265
113Heterotopia (HP:0002282)1.69968374
114Proximal tubulopathy (HP:0000114)1.68316944
115Drooling (HP:0002307)1.67836917
116Bell-shaped thorax (HP:0001591)1.65808845
117Abnormality of the renal cortex (HP:0011035)1.64121032
118Neurofibrillary tangles (HP:0002185)1.64100989
119Congenital malformation of the right heart (HP:0011723)1.64099310
120Double outlet right ventricle (HP:0001719)1.64099310
121Congenital hepatic fibrosis (HP:0002612)1.63171883
122Abnormality of renal excretion (HP:0011036)1.62068999
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.59638965
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58187117
125Abnormality of dentin (HP:0010299)1.52087174
126Asymmetric septal hypertrophy (HP:0001670)1.51448125
127Short ribs (HP:0000773)1.50617992
128Oculomotor apraxia (HP:0000657)1.45341472
129Taurodontia (HP:0000679)1.43851613
130Abnormality of permanent molar morphology (HP:0011071)1.43851613
131Abnormality of the dental root (HP:0006486)1.43851613
132Aplasia/Hypoplasia of the lens (HP:0008063)1.43566331
133Bundle branch block (HP:0011710)1.43369895
134Fibular hypoplasia (HP:0003038)1.42119921
135Renal dysplasia (HP:0000110)1.38418439
136Abnormal urine output (HP:0012590)1.38269214
137Abnormality of the dental pulp (HP:0006479)1.36773588
138Postaxial hand polydactyly (HP:0001162)1.36211056
139Sensory axonal neuropathy (HP:0003390)1.35658434
140Easy fatigability (HP:0003388)1.35580413
141Exercise-induced myalgia (HP:0003738)1.33590267
142Cystic liver disease (HP:0006706)1.33443494
143Abnormality of molar morphology (HP:0011070)1.32810927
144Abnormality of molar (HP:0011077)1.32810927
145Cerebral inclusion bodies (HP:0100314)1.32314533
146Constricted visual fields (HP:0001133)1.32214655
147Facial cleft (HP:0002006)1.29208757
148Chronic sinusitis (HP:0011109)1.28999549
149Deformed sella turcica (HP:0002681)1.27291530
150Absent epiphyses (HP:0010577)1.25428878
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25428878
152Hemiparesis (HP:0001269)1.25327283
153Absent frontal sinuses (HP:0002688)1.23914252
154Hypercholesterolemia (HP:0003124)1.23223741
155Myoglobinuria (HP:0002913)1.23008703
156Abnormality of the neuromuscular junction (HP:0003398)1.22898999
157Fatigable weakness (HP:0003473)1.22898999
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20493397
159Cerebellar dysplasia (HP:0007033)1.19933585
160Broad distal phalanx of finger (HP:0009836)1.19766292
161Abnormality of the lower motor neuron (HP:0002366)1.18634854
162Congenital primary aphakia (HP:0007707)1.16533268
163Gait imbalance (HP:0002141)1.16439169
164Pancreatic fibrosis (HP:0100732)1.15978866
165Loss of speech (HP:0002371)1.15704519
166Nephropathy (HP:0000112)1.15185209
167Truncal obesity (HP:0001956)1.13021622
168Retinal dysplasia (HP:0007973)1.12518448
169Polyuria (HP:0000103)1.12260221
170Abnormality of saccadic eye movements (HP:0000570)1.11734995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.34609113
2PDK48.11922298
3PDK38.11922298
4TESK16.25317985
5PDK25.25791375
6PRKD35.21312007
7ICK4.78812016
8CDK193.12013731
9OXSR12.93839349
10ACVR1B2.85582664
11BMPR1B2.82827778
12NUAK12.33372459
13MAP4K22.29214989
14PTK2B2.21019484
15WNK42.15288358
16STK392.14057130
17TRIM282.12511192
18GRK12.12205279
19PNCK2.06088451
20CASK1.97908389
21ADRBK21.97697672
22INSRR1.84034122
23STK381.73812023
24ZAK1.73539831
25DYRK1B1.67627182
26MKNK21.64157668
27MAP3K41.58221436
28BCR1.53048195
29MAPK131.51812249
30NEK21.38598398
31TNIK1.35161768
32EIF2AK31.24599026
33TNK21.23969696
34PDK11.21885945
35PLK21.21243476
36PAK31.14308763
37TAOK31.09177176
38PIK3CG1.07021249
39EPHA41.06032282
40NTRK31.05156366
41ERBB31.02879024
42CSNK1G10.95927885
43MAPK150.94674326
44FER0.93769968
45CSNK1G20.92965003
46CSNK1G30.91404938
47MAP2K70.89762428
48LATS10.88462494
49PRKCE0.87813738
50DYRK30.87799980
51MARK10.87513747
52FGFR20.87417554
53TGFBR10.86493857
54TXK0.86395946
55AKT30.85941571
56MKNK10.85636672
57TYRO30.85492741
58CSNK1A1L0.85365078
59WNK10.84707101
60BRD40.84381356
61ADRBK10.81691317
62MAP3K70.81448635
63IRAK10.80886662
64MST40.77931864
65PDPK10.75947260
66DAPK20.75726666
67CAMKK20.72308162
68RIPK40.70750940
69NLK0.65141295
70TTK0.64761043
71CAMK1G0.64086941
72PLK30.63125918
73PASK0.61857087
74TEC0.61602781
75MAP2K60.61584043
76CCNB10.61182638
77STK30.60973913
78PRKAA20.60300635
79TESK20.58618142
80PINK10.57350971
81CHEK20.56993249
82EEF2K0.56808017
83MUSK0.56801949
84IRAK20.47339377
85EIF2AK10.44412205
86DYRK20.44076640
87STK38L0.42205314
88LMTK20.41986274
89NTRK20.41878348
90PAK10.41292094
91GRK50.39627662
92CSNK1A10.37501222
93CHEK10.37466085
94PRKCG0.36596941
95MAPKAPK50.35361757
96TIE10.34867099
97TAF10.32375272
98SGK20.32179784
99PAK20.30954584
100CDK30.29225333
101SIK30.28380183
102PBK0.28025536
103ATM0.26948198
104OBSCN0.26023856
105NEK60.25346403
106ATR0.24077999
107MARK20.24031588
108PAK40.23961720
109CLK10.22716693
110MTOR0.22627099
111PLK40.22592069
112MINK10.21413282
113BRSK20.21338747
114MAP3K100.21310062
115CDC70.20301358
116DYRK1A0.19149365
117CDK50.19062993
118EIF2AK20.19016133
119EPHA30.18729233
120PRKCZ0.18199460
121CDK150.17631396
122CAMKK10.17300407
123PRKCQ0.15972664
124PRKAA10.15041197
125CDK180.14941933
126WEE10.14123060
127CDK11A0.13358731
128RPS6KB10.12855069
129BRSK10.12386324
130PLK10.09735211
131CDK140.09312027
132PRKG20.08465267
133PKN10.08128826
134GSK3B0.08006653
135CSNK2A10.07863560
136MARK30.07196091
137CSNK1D0.06572567
138RPS6KA10.05783838
139CSF1R0.04800532
140PRKG10.04362152
141PRKCD0.03637727
142CAMK2A0.03535224
143CDK10.03151121
144CDK60.02819660
145PIM10.02754733
146CDK20.02693249
147PRKCB0.02162847
148STK100.02146058
149PRKACG0.01957214
150MAPK80.01941166
151STK110.01932889
152BRAF0.01412504
153CSNK2A20.01068124
154PRKCA0.00942543
155YES10.00515473
156CSK-0.0316215
157CDK4-0.0299486
158RPS6KA3-0.0290737
159PRKDC-0.0290172
160PRKACA-0.0288868
161MAP3K1-0.0232052
162WNK3-0.0189454
163EPHB1-0.0186259
164PRKACB-0.0185308
165AURKA-0.0180461
166CDK12-0.0125794
167EGFR-0.0108808

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.89251586
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.63233123
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.73900413
4Pyruvate metabolism_Homo sapiens_hsa006203.31397364
5Vitamin B6 metabolism_Homo sapiens_hsa007503.31075707
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.23993899
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16235888
8Linoleic acid metabolism_Homo sapiens_hsa005913.13889238
9Butanoate metabolism_Homo sapiens_hsa006503.07599933
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.93339669
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.90635067
12Phototransduction_Homo sapiens_hsa047442.67394008
13Propanoate metabolism_Homo sapiens_hsa006402.56275804
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.48316025
15Glucagon signaling pathway_Homo sapiens_hsa049222.47031485
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.46056432
17Tryptophan metabolism_Homo sapiens_hsa003802.27098717
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22930324
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11571985
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10877000
21Basal transcription factors_Homo sapiens_hsa030222.10192390
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.08592274
23Caffeine metabolism_Homo sapiens_hsa002321.99741600
24Glycerolipid metabolism_Homo sapiens_hsa005611.94872167
25PPAR signaling pathway_Homo sapiens_hsa033201.89213292
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87149913
27Selenocompound metabolism_Homo sapiens_hsa004501.84728571
28Olfactory transduction_Homo sapiens_hsa047401.83554196
29Nicotine addiction_Homo sapiens_hsa050331.82542118
30Nitrogen metabolism_Homo sapiens_hsa009101.81365507
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75200051
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.73374040
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.71049901
34Mineral absorption_Homo sapiens_hsa049781.66523257
35Protein export_Homo sapiens_hsa030601.61967990
36Fructose and mannose metabolism_Homo sapiens_hsa000511.61516273
37Homologous recombination_Homo sapiens_hsa034401.61005225
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.60727511
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59089134
40Ether lipid metabolism_Homo sapiens_hsa005651.53238515
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51006777
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49864589
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49600483
44Non-homologous end-joining_Homo sapiens_hsa034501.49190198
45Oocyte meiosis_Homo sapiens_hsa041141.48325145
46Fatty acid metabolism_Homo sapiens_hsa012121.47940452
47Fat digestion and absorption_Homo sapiens_hsa049751.45520811
48Fatty acid degradation_Homo sapiens_hsa000711.44170365
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.43531617
50RNA polymerase_Homo sapiens_hsa030201.43434398
51Dorso-ventral axis formation_Homo sapiens_hsa043201.41956430
52Pentose phosphate pathway_Homo sapiens_hsa000301.41696508
53Retinol metabolism_Homo sapiens_hsa008301.40989915
54Amphetamine addiction_Homo sapiens_hsa050311.40657724
55Morphine addiction_Homo sapiens_hsa050321.34860915
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32818816
57Carbon metabolism_Homo sapiens_hsa012001.31182233
58Cardiac muscle contraction_Homo sapiens_hsa042601.30941816
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23713715
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23023439
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22919593
62Fanconi anemia pathway_Homo sapiens_hsa034601.12726619
63Antigen processing and presentation_Homo sapiens_hsa046121.11792973
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.10826800
65beta-Alanine metabolism_Homo sapiens_hsa004101.09119935
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07897013
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07094844
68Purine metabolism_Homo sapiens_hsa002301.02945595
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02699229
70Sphingolipid metabolism_Homo sapiens_hsa006001.02019401
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00981793
72GABAergic synapse_Homo sapiens_hsa047271.00680862
73Renin secretion_Homo sapiens_hsa049241.00667123
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00053382
75Peroxisome_Homo sapiens_hsa041460.98683147
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97981262
77Circadian rhythm_Homo sapiens_hsa047100.97579367
78Glutathione metabolism_Homo sapiens_hsa004800.96792292
79Collecting duct acid secretion_Homo sapiens_hsa049660.95479249
80Serotonergic synapse_Homo sapiens_hsa047260.94069494
81Arachidonic acid metabolism_Homo sapiens_hsa005900.93693858
82mRNA surveillance pathway_Homo sapiens_hsa030150.93651826
83Hedgehog signaling pathway_Homo sapiens_hsa043400.92889356
84Huntingtons disease_Homo sapiens_hsa050160.88835764
85Insulin secretion_Homo sapiens_hsa049110.85846631
86Chemical carcinogenesis_Homo sapiens_hsa052040.84925026
87Biosynthesis of amino acids_Homo sapiens_hsa012300.82175873
88Regulation of autophagy_Homo sapiens_hsa041400.81848705
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.80881715
90Thyroid hormone synthesis_Homo sapiens_hsa049180.79553402
91Bile secretion_Homo sapiens_hsa049760.76799249
92Ovarian steroidogenesis_Homo sapiens_hsa049130.71043463
93RNA transport_Homo sapiens_hsa030130.70693965
94Estrogen signaling pathway_Homo sapiens_hsa049150.70209020
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66591821
96Legionellosis_Homo sapiens_hsa051340.66362303
97Long-term potentiation_Homo sapiens_hsa047200.61715497
98Long-term depression_Homo sapiens_hsa047300.60384713
99Pancreatic secretion_Homo sapiens_hsa049720.59026868
100Fatty acid elongation_Homo sapiens_hsa000620.58613989
101Protein digestion and absorption_Homo sapiens_hsa049740.58232611
102Salivary secretion_Homo sapiens_hsa049700.58180405
103RNA degradation_Homo sapiens_hsa030180.57386919
104Lysine degradation_Homo sapiens_hsa003100.56889324
105Renin-angiotensin system_Homo sapiens_hsa046140.53983872
106Histidine metabolism_Homo sapiens_hsa003400.52684062
107Dopaminergic synapse_Homo sapiens_hsa047280.52267242
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.50696139
109Sulfur metabolism_Homo sapiens_hsa009200.50301597
110One carbon pool by folate_Homo sapiens_hsa006700.50028590
111ABC transporters_Homo sapiens_hsa020100.49819019
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48586235
113Calcium signaling pathway_Homo sapiens_hsa040200.47622143
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45607547
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.45332869
116N-Glycan biosynthesis_Homo sapiens_hsa005100.45288464
117Gastric acid secretion_Homo sapiens_hsa049710.45195433
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44401657
119Synaptic vesicle cycle_Homo sapiens_hsa047210.43289330
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.42450548
121Endocytosis_Homo sapiens_hsa041440.42378203
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41879072
123Metabolic pathways_Homo sapiens_hsa011000.39360516
124Inositol phosphate metabolism_Homo sapiens_hsa005620.39242119
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37726142
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37563589
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36896778
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35005207
129Pyrimidine metabolism_Homo sapiens_hsa002400.33809829
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33434015
131Cholinergic synapse_Homo sapiens_hsa047250.33291450
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33000359
133Systemic lupus erythematosus_Homo sapiens_hsa053220.32971154
134AMPK signaling pathway_Homo sapiens_hsa041520.32672810
135Taste transduction_Homo sapiens_hsa047420.30959018
136Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30107965
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29859562
138cAMP signaling pathway_Homo sapiens_hsa040240.29767842
139Oxytocin signaling pathway_Homo sapiens_hsa049210.27955453
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27502403
141Circadian entrainment_Homo sapiens_hsa047130.24824651
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.24778333
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24595698
144VEGF signaling pathway_Homo sapiens_hsa043700.24123171
145Type I diabetes mellitus_Homo sapiens_hsa049400.23793961
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23453210
147Cocaine addiction_Homo sapiens_hsa050300.21955211
148Alcoholism_Homo sapiens_hsa050340.13812146
149Basal cell carcinoma_Homo sapiens_hsa052170.10761268
150Wnt signaling pathway_Homo sapiens_hsa043100.07636742
151Salmonella infection_Homo sapiens_hsa051320.07011534
152HIF-1 signaling pathway_Homo sapiens_hsa040660.06508919
153B cell receptor signaling pathway_Homo sapiens_hsa046620.06198463
154Glutamatergic synapse_Homo sapiens_hsa047240.04451419
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03953841
156Measles_Homo sapiens_hsa051620.03552960

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