IQCF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.91795776
2spermatid development (GO:0007286)9.77399358
3axonemal dynein complex assembly (GO:0070286)9.54061830
4motile cilium assembly (GO:0044458)9.33556295
5response to pheromone (GO:0019236)9.06828139
6cilium or flagellum-dependent cell motility (GO:0001539)8.34078724
7cilium movement (GO:0003341)8.13873065
8regulation of cilium movement (GO:0003352)7.88951892
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.49778017
10single fertilization (GO:0007338)7.48446208
11sperm capacitation (GO:0048240)7.17537166
12negative regulation of inclusion body assembly (GO:0090084)7.04402566
13synaptonemal complex organization (GO:0070193)6.95952256
14synaptonemal complex assembly (GO:0007130)6.93370879
15male meiosis (GO:0007140)6.79988274
16spermatogenesis (GO:0007283)6.68536880
17male gamete generation (GO:0048232)6.66125227
18microtubule depolymerization (GO:0007019)6.66012490
19organic cation transport (GO:0015695)6.39716415
20rRNA methylation (GO:0031167)6.39690778
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.39295868
22piRNA metabolic process (GO:0034587)6.31321574
23spermatid nucleus differentiation (GO:0007289)6.29810322
24fertilization (GO:0009566)6.27751105
25gamete generation (GO:0007276)6.12587229
26regulation of inclusion body assembly (GO:0090083)5.92418484
27phosphatidylethanolamine metabolic process (GO:0046337)5.87654967
28protein targeting to Golgi (GO:0000042)5.82410020
29calcium ion-dependent exocytosis (GO:0017156)5.68505344
30cellular ketone body metabolic process (GO:0046950)5.67027832
31establishment of protein localization to Golgi (GO:0072600)5.57202769
32sexual reproduction (GO:0019953)5.50103070
33glycerol ether metabolic process (GO:0006662)5.39437415
34retrograde transport, vesicle recycling within Golgi (GO:0000301)5.37474281
35germ cell development (GO:0007281)5.37250742
36rRNA modification (GO:0000154)5.32052783
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.31390475
38chromosome condensation (GO:0030261)5.23014605
39cell recognition (GO:0008037)5.10371579
40single strand break repair (GO:0000012)5.01173276
41ketone body metabolic process (GO:1902224)5.00508568
42ether metabolic process (GO:0018904)4.98726775
43ventricular system development (GO:0021591)4.97952124
44centriole replication (GO:0007099)4.97420100
45RNA destabilization (GO:0050779)4.94165023
46regulation of Rab GTPase activity (GO:0032313)4.90794317
47positive regulation of Rab GTPase activity (GO:0032851)4.90794317
48DNA packaging (GO:0006323)4.88694786
49multicellular organismal reproductive process (GO:0048609)4.81711883
50chromosome organization involved in meiosis (GO:0070192)4.73647565
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64687685
52regulation of microtubule-based movement (GO:0060632)4.63909732
53microtubule severing (GO:0051013)4.49314470
54regulation of transcription involved in cell fate commitment (GO:0060850)4.46876290
55seminiferous tubule development (GO:0072520)4.37648051
56male meiosis I (GO:0007141)4.25975644
57protein localization to Golgi apparatus (GO:0034067)4.21018083
58DNA methylation involved in gamete generation (GO:0043046)4.18031943
59protein K11-linked deubiquitination (GO:0035871)4.17589302
60chaperone-mediated protein complex assembly (GO:0051131)4.15611650
61meiotic nuclear division (GO:0007126)4.00194646
62sequestering of actin monomers (GO:0042989)3.96413183
63coenzyme catabolic process (GO:0009109)3.90516366
64multicellular organismal development (GO:0007275)3.88794330
65regulation of centriole replication (GO:0046599)3.86367155
66left/right pattern formation (GO:0060972)3.86022926
67response to acidic pH (GO:0010447)3.67469617
68genitalia morphogenesis (GO:0035112)3.63429180
69nucleosome disassembly (GO:0006337)3.61112559
70monoubiquitinated protein deubiquitination (GO:0035520)3.60769860
71glomerular visceral epithelial cell development (GO:0072015)3.60411855
72peptidyl-threonine dephosphorylation (GO:0035970)3.56374187
73negative regulation of Rho protein signal transduction (GO:0035024)3.52632437
74microtubule polymerization or depolymerization (GO:0031109)3.46821567
75glomerular epithelial cell development (GO:0072310)3.46477149
76musculoskeletal movement (GO:0050881)3.40462243
77multicellular organismal movement (GO:0050879)3.40462243
78cellular response to pH (GO:0071467)3.38853536
79NAD biosynthetic process (GO:0009435)3.38180608
80regulation of phosphoprotein phosphatase activity (GO:0043666)3.38042956
81meiosis I (GO:0007127)3.38036073
82histone H3-K9 demethylation (GO:0033169)3.37450240
83protein depolymerization (GO:0051261)3.33587333
84glycolytic process (GO:0006096)3.25688032
85regulation of somitogenesis (GO:0014807)3.23230755
86cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22558003
87negative regulation of gene expression, epigenetic (GO:0045814)3.19770153
88protein refolding (GO:0042026)3.19045513
89GTP biosynthetic process (GO:0006183)3.14083657
90nucleoside diphosphate phosphorylation (GO:0006165)3.13936996
91nucleus organization (GO:0006997)3.13214401
92protein polyglutamylation (GO:0018095)3.11876774
93cerebral cortex neuron differentiation (GO:0021895)3.11229919
94polyol catabolic process (GO:0046174)3.10071500
95alditol metabolic process (GO:0019400)3.08005455
96meiotic cell cycle (GO:0051321)3.07648657
97cranial nerve morphogenesis (GO:0021602)3.05484478
98regulation of interleukin-13 production (GO:0032656)3.05125738
99regulation of spindle checkpoint (GO:0090231)3.04427036
100positive regulation of macrophage activation (GO:0043032)3.02395394
101negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.02092458
102chromatin silencing (GO:0006342)2.92112007
103carnitine transport (GO:0015879)2.88784498
104amino-acid betaine transport (GO:0015838)2.88784498
105mitotic sister chromatid cohesion (GO:0007064)2.87423150
106regulation of T-helper 2 cell differentiation (GO:0045628)2.86585457
107homeostasis of number of cells within a tissue (GO:0048873)2.85572744
108membrane protein intracellular domain proteolysis (GO:0031293)2.84855490
109interferon-gamma secretion (GO:0072643)2.83839390
110UTP biosynthetic process (GO:0006228)2.81304375
111protein localization to cilium (GO:0061512)2.80602110
112mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77527111
113mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77527111
114polyamine biosynthetic process (GO:0006596)2.76528580
115cilium organization (GO:0044782)2.75439717
116cellular biogenic amine biosynthetic process (GO:0042401)2.73017320
117histone exchange (GO:0043486)2.71565004
118carnitine transmembrane transport (GO:1902603)2.70363733
119peptidyl-proline hydroxylation (GO:0019511)2.69816343
120DNA conformation change (GO:0071103)2.69806777
121synapsis (GO:0007129)2.69702955
122cellular component assembly involved in morphogenesis (GO:0010927)2.67256845
123lactate metabolic process (GO:0006089)2.66415252
124cilium assembly (GO:0042384)2.66035643
125microtubule-based movement (GO:0007018)2.63389792
126centriole assembly (GO:0098534)2.62551166
127meiotic cell cycle process (GO:1903046)2.62449448
128glycerol metabolic process (GO:0006071)2.60553846
129cilium morphogenesis (GO:0060271)2.57198402
130UTP metabolic process (GO:0046051)2.56209836
131regulation of cilium assembly (GO:1902017)2.51257746
132intraciliary transport (GO:0042073)2.47176757
133cell redox homeostasis (GO:0045454)2.44794775
134axoneme assembly (GO:0035082)2.43335171
135RNA localization (GO:0006403)2.38033118
136protein-DNA complex disassembly (GO:0032986)2.31689447
137cell wall macromolecule metabolic process (GO:0044036)14.8232297
138cell wall macromolecule catabolic process (GO:0016998)14.8232297
139sperm motility (GO:0030317)14.2009044
140fusion of sperm to egg plasma membrane (GO:0007342)14.0779257
141acrosome assembly (GO:0001675)12.2216629
142acrosome reaction (GO:0007340)12.0381330
143sperm-egg recognition (GO:0035036)11.7547035
144multicellular organism reproduction (GO:0032504)11.1799369
145binding of sperm to zona pellucida (GO:0007339)10.7835708
146plasma membrane fusion (GO:0045026)10.7328123
147cell-cell recognition (GO:0009988)10.5341456
148epithelial cilium movement (GO:0003351)10.1942595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.15019527
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.35193654
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91204375
4EZH2_22144423_ChIP-Seq_EOC_Human3.83416933
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.81670175
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47008904
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22113818
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95638206
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84109554
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57523761
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.40302107
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32264999
13VDR_22108803_ChIP-Seq_LS180_Human2.26513607
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12670477
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10666736
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09779013
17ZNF274_21170338_ChIP-Seq_K562_Hela2.07557910
18DROSHA_22980978_ChIP-Seq_HELA_Human2.02874015
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.02752732
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01143591
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.99100060
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98174679
23ERA_21632823_ChIP-Seq_H3396_Human1.97296211
24FUS_26573619_Chip-Seq_HEK293_Human1.96292568
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.93530600
26RAC3_21632823_ChIP-Seq_H3396_Human1.89252373
27CTCF_27219007_Chip-Seq_Bcells_Human1.81506224
28NANOG_20526341_ChIP-Seq_ESCs_Human1.80635220
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80593336
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79002256
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77877426
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.77294408
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77072494
34STAT1_17558387_ChIP-Seq_HELA_Human1.76679979
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76606843
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.76502854
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71259349
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70150557
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69391484
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65124965
41KDM2B_26808549_Chip-Seq_REH_Human1.64314906
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62644275
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61943534
44TAF2_19829295_ChIP-Seq_ESCs_Human1.61866367
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61775989
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60720721
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59511425
48E2F1_20622854_ChIP-Seq_HELA_Human1.57979385
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.57661832
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.57373418
51ER_23166858_ChIP-Seq_MCF-7_Human1.56999593
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56587965
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55294312
54BCL6_27268052_Chip-Seq_Bcells_Human1.54934276
55MYC_19829295_ChIP-Seq_ESCs_Human1.54809402
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54620370
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.54024858
58SMC4_20622854_ChIP-Seq_HELA_Human1.53426358
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.52456893
60PHF8_20622854_ChIP-Seq_HELA_Human1.49259455
61CTCF_20526341_ChIP-Seq_ESCs_Human1.48043637
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47032493
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46444768
64P68_20966046_ChIP-Seq_HELA_Human1.45040234
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.44724739
66OCT4_20526341_ChIP-Seq_ESCs_Human1.44467341
67AR_25329375_ChIP-Seq_VCAP_Human1.44286564
68TP63_22573176_ChIP-Seq_HFKS_Human1.41905313
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41438537
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.40453432
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40040915
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37850096
73CBP_20019798_ChIP-Seq_JUKART_Human1.37850096
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37040986
75P300_27268052_Chip-Seq_Bcells_Human1.35550458
76BCOR_27268052_Chip-Seq_Bcells_Human1.35371350
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35269848
78P53_21459846_ChIP-Seq_SAOS-2_Human1.35106327
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.34288597
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33697268
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33293742
82REST_21632747_ChIP-Seq_MESCs_Mouse1.33122163
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32479008
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30921900
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30143184
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.29883739
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29577073
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.29267049
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.29014541
90LXR_22292898_ChIP-Seq_THP-1_Human1.28774223
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.28720400
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28530353
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28350647
94RBPJ_21746931_ChIP-Seq_IB4_Human1.28080983
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27232703
96TP53_18474530_ChIP-ChIP_U2OS_Human1.26481161
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26248163
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25719608
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25478652
100ETV1_20927104_ChIP-Seq_GIST48_Human1.25070105
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.24774417
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.23801064
103CEBPB_22108803_ChIP-Seq_LS180_Human1.23443829
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22682634
105GF1_26923725_Chip-Seq_HPCs_Mouse1.22387155
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22351902
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.21773004
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21295224
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.20122534
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.19909496
111P300_19829295_ChIP-Seq_ESCs_Human1.19698035
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19307859
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19018556
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16645280
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16645280
116TBL1_22424771_ChIP-Seq_293T_Human1.15788590
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14627308
118TAF15_26573619_Chip-Seq_HEK293_Human1.14377642
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14053087
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13638546
121SA1_27219007_Chip-Seq_Bcells_Human1.13393462
122SMRT_27268052_Chip-Seq_Bcells_Human1.12804481
123CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12579368
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12161118
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11999264
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10889835
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.10698431
128P53_22387025_ChIP-Seq_ESCs_Mouse1.10529317
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.10276139
130SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10145876
131RUNX2_22187159_ChIP-Seq_PCA_Human1.09730739
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09465138
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.09256015
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.09031181
135PHF8_20622853_ChIP-Seq_HELA_Human1.08086857
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07886363
137ESET_19884257_ChIP-Seq_ESCs_Mouse1.07718571
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05964334
139SMAD4_21799915_ChIP-Seq_A2780_Human1.05353764
140OCT1_27270436_Chip-Seq_PROSTATE_Human1.04679797
141BP1_19119308_ChIP-ChIP_Hs578T_Human1.04406836
142RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03585081
143P300_18555785_Chip-Seq_ESCs_Mouse1.02625062
144HOXB7_26014856_ChIP-Seq_BT474_Human1.02045873
145ERG_20517297_ChIP-Seq_VCAP_Human1.01290795
146GATA6_21074721_ChIP-Seq_CACO-2_Human1.00792630
147RUNX_20019798_ChIP-Seq_JUKART_Human1.00459315
148NFYA_21822215_ChIP-Seq_K562_Human1.00006160
149NANOG_19829295_ChIP-Seq_ESCs_Human0.99864885
150SOX2_19829295_ChIP-Seq_ESCs_Human0.99864885
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99620339
152CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99540449
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99539429
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98850151
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98792140
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.98016071
157SOX9_26525672_Chip-Seq_HEART_Mouse0.97549209
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97171027
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97087859
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96744047
161EZH2_27294783_Chip-Seq_NPCs_Mouse0.95926131
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.95187200
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94456345
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.94232787
165RNF2_27304074_Chip-Seq_NSC_Mouse0.94226840
166FLI1_21867929_ChIP-Seq_CD8_Mouse0.94038990
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93942398
168RARA_24833708_ChIP-Seq_LIVER_Mouse0.93770133
169ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93609507
170SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92982576
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92956444
172NFYB_21822215_ChIP-Seq_K562_Human0.92760684
173PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92498426
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.90454846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.18139213
2MP0001929_abnormal_gametogenesis5.66780605
3MP0008877_abnormal_DNA_methylation3.89477206
4MP0002210_abnormal_sex_determination3.40356522
5MP0002161_abnormal_fertility/fecundity3.35678884
6MP0001348_abnormal_lacrimal_gland3.24199256
7MP0005670_abnormal_white_adipose2.91587212
8MP0001145_abnormal_male_reproductive2.89590645
9MP0000653_abnormal_sex_gland2.50871889
10MP0000678_abnormal_parathyroid_gland2.48566687
11MP0003718_maternal_effect2.17452479
12MP0005410_abnormal_fertilization16.6922875
13MP0002653_abnormal_ependyma_morphology1.97290949
14MP0005423_abnormal_somatic_nervous1.70220860
15MP0005379_endocrine/exocrine_gland_phen1.62509872
16MP0001485_abnormal_pinna_reflex1.62303009
17MP0002249_abnormal_larynx_morphology1.51692509
18MP0001486_abnormal_startle_reflex1.48702055
19MP0002160_abnormal_reproductive_system1.44400624
20MP0005248_abnormal_Harderian_gland1.42306287
21MP0004233_abnormal_muscle_weight1.39009486
22MP0009053_abnormal_anal_canal1.32774245
23MP0001765_abnormal_ion_homeostasis1.25964415
24MP0003646_muscle_fatigue1.21834988
25MP0005623_abnormal_meninges_morphology1.21575862
26MP0002735_abnormal_chemical_nociception1.19173817
27MP0002282_abnormal_trachea_morphology1.16805214
28MP0002822_catalepsy1.16401965
29MP0002127_abnormal_cardiovascular_syste1.16361200
30MP0004510_myositis1.15606550
31MP0004859_abnormal_synaptic_plasticity1.13918383
32MP0001905_abnormal_dopamine_level1.12499280
33MP0001963_abnormal_hearing_physiology1.12087302
34MP0005310_abnormal_salivary_gland1.09424931
35MP0005395_other_phenotype1.07940737
36MP0000026_abnormal_inner_ear1.03771825
37MP0002234_abnormal_pharynx_morphology0.99214457
38MP0008058_abnormal_DNA_repair0.99018290
39MP0002733_abnormal_thermal_nociception0.97808510
40MP0005647_abnormal_sex_gland0.93864964
41MP0001984_abnormal_olfaction0.93842779
42MP0002138_abnormal_hepatobiliary_system0.93741400
43MP0002067_abnormal_sensory_capabilities0.90234100
44MP0000955_abnormal_spinal_cord0.89590364
45MP0000049_abnormal_middle_ear0.86981809
46MP0004085_abnormal_heartbeat0.80430472
47MP0002557_abnormal_social/conspecific_i0.80269842
48MP0000681_abnormal_thyroid_gland0.75908739
49MP0005636_abnormal_mineral_homeostasis0.74814906
50MP0009046_muscle_twitch0.71980546
51MP0005389_reproductive_system_phenotype0.70961067
52MP0008995_early_reproductive_senescence0.70501501
53MP0003011_delayed_dark_adaptation0.69725656
54MP0005083_abnormal_biliary_tract0.68284335
55MP0002572_abnormal_emotion/affect_behav0.66579505
56MP0001879_abnormal_lymphatic_vessel0.64261341
57MP0001970_abnormal_pain_threshold0.63967766
58MP0003115_abnormal_respiratory_system0.59524920
59MP0002272_abnormal_nervous_system0.58503291
60MP0005666_abnormal_adipose_tissue0.57497830
61MP0002736_abnormal_nociception_after0.57139052
62MP0009745_abnormal_behavioral_response0.56680013
63MP0001764_abnormal_homeostasis0.55324891
64MP0005367_renal/urinary_system_phenotyp0.55014009
65MP0000516_abnormal_urinary_system0.55014009
66MP0003119_abnormal_digestive_system0.54127508
67MP0003635_abnormal_synaptic_transmissio0.53953186
68MP0005167_abnormal_blood-brain_barrier0.53501376
69MP0004484_altered_response_of0.53358954
70MP0003632_abnormal_nervous_system0.53227356
71MP0001324_abnormal_eye_pigmentation0.52676736
72MP0004036_abnormal_muscle_relaxation0.51422765
73MP0000249_abnormal_blood_vessel0.51087909
74MP0000566_synostosis0.50049993
75MP0001501_abnormal_sleep_pattern0.49737250
76MP0000470_abnormal_stomach_morphology0.49546022
77MP0005451_abnormal_body_composition0.48740114
78MP0005377_hearing/vestibular/ear_phenot0.48660596
79MP0003878_abnormal_ear_physiology0.48660596
80MP0003137_abnormal_impulse_conducting0.48254590
81MP0010094_abnormal_chromosome_stability0.46899069
82MP0001666_abnormal_nutrient_absorption0.46886115
83MP0002102_abnormal_ear_morphology0.46850607
84MP0005394_taste/olfaction_phenotype0.46551118
85MP0005499_abnormal_olfactory_system0.46551118
86MP0002928_abnormal_bile_duct0.46038877
87MP0005551_abnormal_eye_electrophysiolog0.45885593
88MP0001293_anophthalmia0.45658341
89MP0004019_abnormal_vitamin_homeostasis0.45385185
90MP0002139_abnormal_hepatobiliary_system0.45126480
91MP0006036_abnormal_mitochondrial_physio0.44982895
92MP0003699_abnormal_female_reproductive0.44259698
93MP0000358_abnormal_cell_content/0.43528676
94MP0000569_abnormal_digit_pigmentation0.43473871
95MP0002269_muscular_atrophy0.43027864
96MP0005253_abnormal_eye_physiology0.42328571
97MP0001440_abnormal_grooming_behavior0.41939445
98MP0002734_abnormal_mechanical_nocicepti0.41564214
99MP0005535_abnormal_body_temperature0.41258669
100MP0003329_amyloid_beta_deposits0.41206961
101MP0003936_abnormal_reproductive_system0.40219802
102MP0000230_abnormal_systemic_arterial0.40098525
103MP0002882_abnormal_neuron_morphology0.38486743
104MP0002168_other_aberrant_phenotype0.38025184
105MP0000003_abnormal_adipose_tissue0.37427067
106MP0003136_yellow_coat_color0.36376226
107MP0000613_abnormal_salivary_gland0.36269111
108MP0008961_abnormal_basal_metabolism0.36078426
109MP0003880_abnormal_central_pattern0.35488988
110MP0009115_abnormal_fat_cell0.35208821
111MP0001968_abnormal_touch/_nociception0.34963271
112MP0002932_abnormal_joint_morphology0.33742664
113MP0001545_abnormal_hematopoietic_system0.33387027
114MP0005397_hematopoietic_system_phenotyp0.33387027
115MP0004133_heterotaxia0.31057499
116MP0002971_abnormal_brown_adipose0.30860383
117MP0001119_abnormal_female_reproductive0.30837505
118MP0005391_vision/eye_phenotype0.30383750
119MP0003633_abnormal_nervous_system0.29279710
120MP0003950_abnormal_plasma_membrane0.29242558
121MP0000534_abnormal_ureter_morphology0.27207110
122MP0000462_abnormal_digestive_system0.26670733
123MP0003111_abnormal_nucleus_morphology0.25558477
124MP0002169_no_abnormal_phenotype0.23666433
125MP0009278_abnormal_bone_marrow0.23596775
126MP0002873_normal_phenotype0.23397441
127MP0008057_abnormal_DNA_replication0.23343734
128MP0000604_amyloidosis0.23102477
129MP0004811_abnormal_neuron_physiology0.23032778
130MP0005365_abnormal_bile_salt0.22205531
131MP0006035_abnormal_mitochondrial_morpho0.21335040
132MP0003786_premature_aging0.21187988
133MP0003631_nervous_system_phenotype0.21046813
134MP0003861_abnormal_nervous_system0.20281717
135MP0002693_abnormal_pancreas_physiology0.19936402
136MP0005319_abnormal_enzyme/_coenzyme0.19884006
137MP0003948_abnormal_gas_homeostasis0.19806283
138MP0001849_ear_inflammation0.19253902
139MP0004742_abnormal_vestibular_system0.19151990
140MP0004043_abnormal_pH_regulation0.19013183
141MP0001730_embryonic_growth_arrest0.18786102
142MP0002152_abnormal_brain_morphology0.18370150
143MP0003942_abnormal_urinary_system0.18269311
144MP0004145_abnormal_muscle_electrophysio0.17703676
145MP0010307_abnormal_tumor_latency0.17619148
146MP0006072_abnormal_retinal_apoptosis0.16725135
147MP0009697_abnormal_copulation0.15976684
148MP0002132_abnormal_respiratory_system0.15650540
149MP0008569_lethality_at_weaning0.15650075
150MP0008875_abnormal_xenobiotic_pharmacok0.15452559
151MP0004084_abnormal_cardiac_muscle0.14536458
152MP0003879_abnormal_hair_cell0.13820801
153MP0002092_abnormal_eye_morphology0.13794772
154MP0002295_abnormal_pulmonary_circulatio0.13709437
155MP0005375_adipose_tissue_phenotype0.13702747
156MP0005503_abnormal_tendon_morphology0.13480224
157MP0000001_mammalian_phenotype0.13402146
158MP0001270_distended_abdomen0.13351669
159MP0003283_abnormal_digestive_organ0.12616919
160MP0001727_abnormal_embryo_implantation0.12469259
161MP0005195_abnormal_posterior_eye0.12413435
162MP0002229_neurodegeneration0.12380970
163MP0009250_abnormal_appendicular_skeleto0.12164042

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.60764686
2Abnormal respiratory epithelium morphology (HP:0012253)9.58306870
3Abnormal respiratory motile cilium morphology (HP:0005938)9.58306870
4Severe visual impairment (HP:0001141)7.84888935
5Abnormal ciliary motility (HP:0012262)7.83205811
6Chronic bronchitis (HP:0004469)7.63013170
7Rhinitis (HP:0012384)7.48105548
8Infertility (HP:0000789)6.76201018
9Nasal polyposis (HP:0100582)6.31096049
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.37661138
11Abnormality of the nasal mucosa (HP:0000433)5.18381981
12Bony spicule pigmentary retinopathy (HP:0007737)4.85763466
13Attenuation of retinal blood vessels (HP:0007843)4.81695203
14Resting tremor (HP:0002322)4.59783653
15Male infertility (HP:0003251)4.59546685
16Bronchitis (HP:0012387)4.46386872
17Hyperkalemia (HP:0002153)4.46351817
18Bronchiectasis (HP:0002110)4.34584411
19Enlarged epiphyses (HP:0010580)4.22028318
20Abnormal rod and cone electroretinograms (HP:0008323)4.00474436
21Chronic hepatic failure (HP:0100626)3.93316374
22Nephronophthisis (HP:0000090)3.83867558
23Facial shape deformation (HP:0011334)3.80068587
24Potter facies (HP:0002009)3.80068587
25Abnormality of macular pigmentation (HP:0008002)3.75185181
26Hypoplastic ischia (HP:0003175)3.62225298
27Recurrent sinusitis (HP:0011108)3.59532522
28Abnormal spermatogenesis (HP:0008669)3.40644343
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.22274482
30Recurrent otitis media (HP:0000403)3.21356718
31Abnormality of the ischium (HP:0003174)3.21191987
32Postural instability (HP:0002172)3.14709696
33Cone-rod dystrophy (HP:0000548)3.08889500
34Abnormality of the aortic arch (HP:0012303)2.99927492
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.95817353
36Abnormality of the renal medulla (HP:0100957)2.90609936
37Unilateral renal agenesis (HP:0000122)2.87853513
38Hypoplasia of the thymus (HP:0000778)2.87152742
39Tubulointerstitial nephritis (HP:0001970)2.82277412
40Progressive cerebellar ataxia (HP:0002073)2.62676732
41Abnormality of potassium homeostasis (HP:0011042)2.58956885
42Progressive sensorineural hearing impairment (HP:0000408)2.58522541
43Medial flaring of the eyebrow (HP:0010747)2.57773960
44Molar tooth sign on MRI (HP:0002419)2.48064798
45Abnormality of midbrain morphology (HP:0002418)2.48064798
46Generalized aminoaciduria (HP:0002909)2.44698022
47Hypoalphalipoproteinemia (HP:0003233)2.43888999
48Abnormality of the pubic bones (HP:0003172)2.43107578
49Renovascular hypertension (HP:0100817)2.42835313
50Tubular atrophy (HP:0000092)2.42477784
51Focal segmental glomerulosclerosis (HP:0000097)2.37190718
52Recurrent bronchitis (HP:0002837)2.35302674
53Myokymia (HP:0002411)2.30977811
54Abnormality of the costochondral junction (HP:0000919)2.29023225
55Tubulointerstitial abnormality (HP:0001969)2.26083121
56Flattened epiphyses (HP:0003071)2.25873115
57Tetany (HP:0001281)2.25751537
58Truncal obesity (HP:0001956)2.25143097
59Amelogenesis imperfecta (HP:0000705)2.22129321
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.21067391
61Impulsivity (HP:0100710)2.18565723
62Insulin-resistant diabetes mellitus (HP:0000831)2.18395557
63Epiphyseal dysplasia (HP:0002656)2.15947328
64Ventricular tachycardia (HP:0004756)2.14684739
65Polyuria (HP:0000103)2.13274477
66Azoospermia (HP:0000027)2.13263150
67Abnormality of the parathyroid morphology (HP:0011766)2.12280033
68Bradycardia (HP:0001662)2.11682407
69Abnormal gallbladder physiology (HP:0012438)2.10819506
70Cholecystitis (HP:0001082)2.10819506
71Dyschromatopsia (HP:0007641)2.09197871
72Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.06827884
73Abnormality of femoral epiphyses (HP:0006499)2.06827884
74Portal hypertension (HP:0001409)2.05197773
75Gonadotropin excess (HP:0000837)2.02055491
76Menstrual irregularities (HP:0000858)2.00333297
77Absent/shortened dynein arms (HP:0200106)13.9974141
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.9974141
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1238599
80Abnormality of dental color (HP:0011073)1.97667083
81Abnormality of the femoral head (HP:0003368)1.95227027
82Flat capital femoral epiphysis (HP:0003370)1.93234104
83Recurrent pneumonia (HP:0006532)1.92093231
84Decreased central vision (HP:0007663)1.90649458
85Osteomalacia (HP:0002749)1.89025497
86Hyperthyroidism (HP:0000836)1.86889549
87Abnormality of the hepatic vasculature (HP:0006707)1.86774521
88Widely patent fontanelles and sutures (HP:0004492)1.85505219
89Congenital sensorineural hearing impairment (HP:0008527)1.84180034
90Preauricular pit (HP:0004467)1.83425888
91Periauricular skin pits (HP:0100277)1.83425888
92Hyponatremia (HP:0002902)1.83036032
93Neoplasm of the heart (HP:0100544)1.82360604
94Increased purine levels (HP:0004368)1.82192428
95Hyperuricemia (HP:0002149)1.82192428
96Recurrent corneal erosions (HP:0000495)1.80571715
97Abnormal ventriculo-arterial connection (HP:0011563)1.78324503
98Transposition of the great arteries (HP:0001669)1.78324503
99Abnormal connection of the cardiac segments (HP:0011545)1.78324503
100Glomerulosclerosis (HP:0000096)1.77021842
101Asymmetric septal hypertrophy (HP:0001670)1.72883844
102Postaxial foot polydactyly (HP:0001830)1.70702216
103Tubulointerstitial fibrosis (HP:0005576)1.70548876
104Stage 5 chronic kidney disease (HP:0003774)1.68515536
105Abnormality of renal excretion (HP:0011036)1.64790394
106Choroideremia (HP:0001139)1.64362468
107Spastic tetraparesis (HP:0001285)1.61997855
108Double outlet right ventricle (HP:0001719)1.61237435
109Congenital malformation of the right heart (HP:0011723)1.61237435
110Abnormality of permanent molar morphology (HP:0011071)1.58123038
111Abnormality of the dental root (HP:0006486)1.58123038
112Taurodontia (HP:0000679)1.58123038
113Abnormality of the renal cortex (HP:0011035)1.58077231
114Congenital primary aphakia (HP:0007707)1.55846836
115Gait imbalance (HP:0002141)1.55749772
116Aplasia/Hypoplasia of the lens (HP:0008063)1.55506516
117Congenital hepatic fibrosis (HP:0002612)1.54046086
118Abnormal drinking behavior (HP:0030082)1.52129916
119Polydipsia (HP:0001959)1.52129916
120Abnormal biliary tract physiology (HP:0012439)1.51610250
121Bile duct proliferation (HP:0001408)1.51610250
122Bundle branch block (HP:0011710)1.51349928
123Heterotopia (HP:0002282)1.48659995
124Hemorrhage of the eye (HP:0011885)1.48229970
125Abnormality of the dental pulp (HP:0006479)1.47035114
126Abnormality of molar (HP:0011077)1.46360297
127Abnormality of molar morphology (HP:0011070)1.46360297
128Chronic sinusitis (HP:0011109)1.42098729
129Short ribs (HP:0000773)1.40981634
130Oculomotor apraxia (HP:0000657)1.40878326
131Postaxial hand polydactyly (HP:0001162)1.40852268
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.40339797
133Constricted visual fields (HP:0001133)1.39623530
134Fibular hypoplasia (HP:0003038)1.38737520
135Cystic liver disease (HP:0006706)1.38095914
136Bell-shaped thorax (HP:0001591)1.37149180
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.35943152
138Vascular calcification (HP:0004934)1.33092089
139Nephrogenic diabetes insipidus (HP:0009806)1.31541175
140Abnormality of dentin (HP:0010299)1.30820359
141Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29412000
142Neurofibrillary tangles (HP:0002185)1.28580530
143Pancreatic fibrosis (HP:0100732)1.28083354
144Sensory axonal neuropathy (HP:0003390)1.27478526
145Abnormal urine output (HP:0012590)1.25859357
146Vaginal atresia (HP:0000148)1.24157668
147Easy fatigability (HP:0003388)1.24016137
148Abnormality of the neuromuscular junction (HP:0003398)1.23549587
149Fatigable weakness (HP:0003473)1.23549587
150Renal dysplasia (HP:0000110)1.23537201
151Facial cleft (HP:0002006)1.23198385
152Cerebellar dysplasia (HP:0007033)1.22620581
153Genital tract atresia (HP:0001827)1.20796508
154Exercise-induced myalgia (HP:0003738)1.20677806
155Cardiovascular calcification (HP:0011915)1.19354487
156True hermaphroditism (HP:0010459)1.18451325
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.17809024
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.16208379
159Absent epiphyses (HP:0010577)1.16208379
160Myoglobinuria (HP:0002913)1.16077272
161Poor coordination (HP:0002370)1.15315458
162Optic nerve hypoplasia (HP:0000609)1.14913645
163Abnormality of the lower motor neuron (HP:0002366)1.12808311
164Abnormality of saccadic eye movements (HP:0000570)1.12807862
165Deformed sella turcica (HP:0002681)1.10141807
166Supernumerary spleens (HP:0009799)1.08971734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.22090043
2PDK49.22090043
3PDK26.00633831
4TESK15.09800854
5DDR24.82828446
6PRKD33.85359408
7ICK3.71086542
8MAP4K23.37775688
9INSRR3.32899278
10PLK22.65970506
11BRD42.51302682
12WNK41.88772579
13PTK2B1.88311083
14STK391.85486709
15MST1R1.70848174
16STK381.51937743
17PNCK1.48785602
18DYRK1B1.37923774
19LATS21.37600715
20NEK21.37023266
21CAMK1D1.32743370
22PDK11.23248288
23MAP3K91.20922295
24CDK71.18780505
25ARAF1.15743082
26IRAK10.97924506
27PASK0.86239075
28DYRK30.84096343
29LMTK20.83027045
30KSR20.82313215
31UHMK10.78795751
32RPS6KA20.77473412
33MARK10.71879612
34CCNB10.69388150
35PDPK10.68601469
36TYRO30.68590728
37AKT30.65786362
38WNK10.65296152
39RIPK40.64674727
40MAPK150.62546439
41MAP2K60.62243163
42CDK30.61480464
43PRKAA20.61003049
44ROCK10.59408276
45MAP2K20.58552833
46CAMK10.57199554
47STK30.52957963
48CHEK20.52790884
49STK38L0.50442125
50MAP3K80.50130618
51EEF2K0.49853310
52TTK0.49768263
53TESK20.48147753
54IRAK20.47349828
55ZAK0.47307603
56BMPR1B0.46758744
57PINK10.43942200
58SGK2230.43611930
59SGK4940.43611930
60MAP3K20.41610639
61MAPK10.40865196
62MUSK0.39323405
63CAMK40.37938932
64RPS6KL10.37501731
65RPS6KC10.37501731
66RPS6KA60.37455892
67MAP3K110.37007071
68SIK20.36979182
69PLK40.36849901
70CAMK1G0.36066985
71LATS10.35542052
72CHEK10.34860925
73PAK10.32956347
74NTRK20.32216031
75PRKCG0.32111618
76MAPK130.32029541
77MAP3K100.30932982
78RPS6KA50.30276364
79SGK10.26138562
80NUAK10.25846196
81CAMKK10.25378996
82MAPK140.24829712
83BRSK20.24643336
84MAPKAPK50.22936390
85PAK20.22811753
86ATM0.22368757
87NTRK30.21432898
88PRKG20.21059049
89MAP3K40.20621822
90WEE10.20045334
91MAPK100.19695402
92TAOK30.19014094
93PRKCZ0.18776860
94AKT10.18180958
95MET0.18138919
96MAP3K10.17748611
97TIE10.17536493
98ATR0.17532723
99NEK60.16705246
100MAPK110.16176197
101MARK20.15729588
102ACVR1B0.15624920
103CDK150.15415506
104MTOR0.15373316
105PRKCQ0.13943707
106JAK30.13187763
107MARK30.12916419
108MYLK0.12911222
109PRKAA10.12767833
110CDK180.12709678
111MAP2K70.12400950
112TLK10.12372938
113PLK10.12093211
114CDK11A0.11758794
115PAK40.11094537
116PKN10.10845450
117BRSK10.09935545
118RPS6KB10.09917660
119CDK140.08418515
120BRAF0.08094162
121CSNK2A10.07631958
122PRKG10.07022526
123PRKACG0.05471594
124GSK3B0.04143153
125RPS6KA10.04118501
126CDC70.03731670
127CSNK2A20.03111958
128STK100.03045106
129PIK3CG0.03017311
130YES10.02810822
131PRKCD0.02596782
132CAMK2A0.02196000
133PRKCB0.01579855
134CSNK1D0.01479299
135PRKCA0.01140372
136CDK120.00997888
137PIM10.00977460
138CDK10.00669589
139CDK60.00621754
140RIPK10.00377342
141MAPK80.00324237
142CDK20.00302189
143CSF1R0.00176170
144STK110.00108148
145CDK4-0.0435334
146PRKDC-0.0407037
147AURKA-0.0309698
148RPS6KA3-0.0234196
149PRKACA-0.0224483
150MAP3K5-0.0215076
151EGFR-0.0184133
152GSK3A-0.0179810
153PRKACB-0.0117640
154WNK3-0.0087480

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.56275031
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.61353866
3Fatty acid biosynthesis_Homo sapiens_hsa000614.34419443
4Vitamin B6 metabolism_Homo sapiens_hsa007504.08520360
5Pyruvate metabolism_Homo sapiens_hsa006203.63515473
6Olfactory transduction_Homo sapiens_hsa047403.40554066
7Butanoate metabolism_Homo sapiens_hsa006503.28551774
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92486663
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.90092394
10Propanoate metabolism_Homo sapiens_hsa006402.84780935
11Linoleic acid metabolism_Homo sapiens_hsa005912.83827552
12Glucagon signaling pathway_Homo sapiens_hsa049222.63621839
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25815433
14Basal transcription factors_Homo sapiens_hsa030222.23185825
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.07608339
16Selenocompound metabolism_Homo sapiens_hsa004502.01547987
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95811821
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94512020
19Glycerolipid metabolism_Homo sapiens_hsa005611.90496864
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89839702
21PPAR signaling pathway_Homo sapiens_hsa033201.82538034
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82151670
23Type I diabetes mellitus_Homo sapiens_hsa049401.71709847
24Oocyte meiosis_Homo sapiens_hsa041141.68943195
25Type II diabetes mellitus_Homo sapiens_hsa049301.66393657
26Pentose phosphate pathway_Homo sapiens_hsa000301.63968502
27Mineral absorption_Homo sapiens_hsa049781.63390691
28Phenylalanine metabolism_Homo sapiens_hsa003601.63172074
29Allograft rejection_Homo sapiens_hsa053301.61252508
30Autoimmune thyroid disease_Homo sapiens_hsa053201.57015138
31Phototransduction_Homo sapiens_hsa047441.56883212
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.51092484
33Graft-versus-host disease_Homo sapiens_hsa053321.50323573
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48827188
35Fructose and mannose metabolism_Homo sapiens_hsa000511.48476938
36Carbon metabolism_Homo sapiens_hsa012001.43524214
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42667639
38Amphetamine addiction_Homo sapiens_hsa050311.41885283
39Fat digestion and absorption_Homo sapiens_hsa049751.39786513
40Cardiac muscle contraction_Homo sapiens_hsa042601.36841405
41Arginine and proline metabolism_Homo sapiens_hsa003301.32594543
42Morphine addiction_Homo sapiens_hsa050321.31828310
43Fatty acid degradation_Homo sapiens_hsa000711.30614437
44Ether lipid metabolism_Homo sapiens_hsa005651.29344467
45Fatty acid metabolism_Homo sapiens_hsa012121.27785204
46Tyrosine metabolism_Homo sapiens_hsa003501.21911793
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21290603
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.17338614
49Fanconi anemia pathway_Homo sapiens_hsa034601.14300558
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12182435
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11254608
52Nicotine addiction_Homo sapiens_hsa050331.10910030
53Collecting duct acid secretion_Homo sapiens_hsa049661.07744999
54Purine metabolism_Homo sapiens_hsa002301.07633949
55Glutathione metabolism_Homo sapiens_hsa004801.06858431
56Dorso-ventral axis formation_Homo sapiens_hsa043201.06080543
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05472349
58Renin secretion_Homo sapiens_hsa049241.05421411
59Viral myocarditis_Homo sapiens_hsa054161.01308672
60Arginine biosynthesis_Homo sapiens_hsa002200.99766559
61Antigen processing and presentation_Homo sapiens_hsa046120.99745566
62Huntingtons disease_Homo sapiens_hsa050160.96692031
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96559303
64Biosynthesis of amino acids_Homo sapiens_hsa012300.90834935
65Chemical carcinogenesis_Homo sapiens_hsa052040.89690466
66Insulin secretion_Homo sapiens_hsa049110.87767496
67Hedgehog signaling pathway_Homo sapiens_hsa043400.86928461
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84420421
69Bile secretion_Homo sapiens_hsa049760.83384807
70Thyroid hormone synthesis_Homo sapiens_hsa049180.80864133
71Cholinergic synapse_Homo sapiens_hsa047250.80614196
72Arachidonic acid metabolism_Homo sapiens_hsa005900.77664018
73mRNA surveillance pathway_Homo sapiens_hsa030150.74467805
74Nitrogen metabolism_Homo sapiens_hsa009100.69395486
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68364577
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.67062891
77GABAergic synapse_Homo sapiens_hsa047270.66255174
78Estrogen signaling pathway_Homo sapiens_hsa049150.65573804
79Long-term potentiation_Homo sapiens_hsa047200.62970444
80Protein digestion and absorption_Homo sapiens_hsa049740.62646574
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62109789
82RNA transport_Homo sapiens_hsa030130.61639428
83Serotonergic synapse_Homo sapiens_hsa047260.60490348
84Influenza A_Homo sapiens_hsa051640.60290180
85Pancreatic secretion_Homo sapiens_hsa049720.59241342
86Tryptophan metabolism_Homo sapiens_hsa003800.58897413
87Salivary secretion_Homo sapiens_hsa049700.58592646
88Inositol phosphate metabolism_Homo sapiens_hsa005620.57579427
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.56605148
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55871171
91Calcium signaling pathway_Homo sapiens_hsa040200.55592037
92Sulfur metabolism_Homo sapiens_hsa009200.55028645
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54252061
94ABC transporters_Homo sapiens_hsa020100.54111629
95Legionellosis_Homo sapiens_hsa051340.52835220
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51665878
97Prolactin signaling pathway_Homo sapiens_hsa049170.50857009
98Gastric acid secretion_Homo sapiens_hsa049710.49998319
99Systemic lupus erythematosus_Homo sapiens_hsa053220.49077420
100Renin-angiotensin system_Homo sapiens_hsa046140.48941388
101Synaptic vesicle cycle_Homo sapiens_hsa047210.48201213
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.48007301
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46837623
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45058164
105MAPK signaling pathway_Homo sapiens_hsa040100.45007516
106Metabolic pathways_Homo sapiens_hsa011000.44615960
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.44167951
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43724563
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42634550
110Viral carcinogenesis_Homo sapiens_hsa052030.38911631
111Acute myeloid leukemia_Homo sapiens_hsa052210.38443814
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.38290305
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37769442
114Tight junction_Homo sapiens_hsa045300.37230155
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36751672
116AMPK signaling pathway_Homo sapiens_hsa041520.36218429
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.34680713
118Oxytocin signaling pathway_Homo sapiens_hsa049210.34285275
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33686105
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33168347
121Endocytosis_Homo sapiens_hsa041440.32994031
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31890793
123cAMP signaling pathway_Homo sapiens_hsa040240.30873513
124Pyrimidine metabolism_Homo sapiens_hsa002400.30220821
125VEGF signaling pathway_Homo sapiens_hsa043700.28754896
126Taste transduction_Homo sapiens_hsa047420.26835520
127Circadian entrainment_Homo sapiens_hsa047130.25394083
128Gap junction_Homo sapiens_hsa045400.22306761
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18448750
130Dopaminergic synapse_Homo sapiens_hsa047280.17364831
131Alcoholism_Homo sapiens_hsa050340.16980044
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.16255189
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.15828979
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.14790951
135Cocaine addiction_Homo sapiens_hsa050300.12312038
136Wnt signaling pathway_Homo sapiens_hsa043100.10618180
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08557798
138HIF-1 signaling pathway_Homo sapiens_hsa040660.08432929
139N-Glycan biosynthesis_Homo sapiens_hsa005100.08179909
140B cell receptor signaling pathway_Homo sapiens_hsa046620.07471130
141Retinol metabolism_Homo sapiens_hsa008300.05593677
142Basal cell carcinoma_Homo sapiens_hsa052170.04021915
143Glutamatergic synapse_Homo sapiens_hsa047240.00407344

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