IQCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)6.23019727
2fatty acid elongation (GO:0030497)6.21726140
3ensheathment of neurons (GO:0007272)5.93462495
4axon ensheathment (GO:0008366)5.93462495
5myelination (GO:0042552)5.90127988
6intraciliary transport (GO:0042073)5.19045816
7long-chain fatty acid biosynthetic process (GO:0042759)5.14603164
8regulation of cilium movement (GO:0003352)4.56158144
9photoreceptor cell differentiation (GO:0046530)4.52970641
10eye photoreceptor cell differentiation (GO:0001754)4.52970641
11negative regulation of neurotransmitter transport (GO:0051589)4.45757647
12regulation of timing of cell differentiation (GO:0048505)4.23688277
13cilium morphogenesis (GO:0060271)4.22796924
14negative regulation of neurotransmitter secretion (GO:0046929)4.19376166
15oligodendrocyte differentiation (GO:0048709)4.14106452
16motile cilium assembly (GO:0044458)4.13524366
17limb bud formation (GO:0060174)4.11635321
18cilium organization (GO:0044782)3.98845043
19presynaptic membrane organization (GO:0097090)3.93093424
20cilium assembly (GO:0042384)3.92914156
21regulation of development, heterochronic (GO:0040034)3.91458565
22protein localization to cilium (GO:0061512)3.90547462
23positive regulation of oligodendrocyte differentiation (GO:0048714)3.86580166
24L-amino acid import (GO:0043092)3.85462929
25neuron cell-cell adhesion (GO:0007158)3.82895873
26establishment of mitochondrion localization (GO:0051654)3.82883332
27regulation of collateral sprouting (GO:0048670)3.80325616
28negative regulation of protein localization to cell surface (GO:2000009)3.79074820
29myelin maintenance (GO:0043217)3.78364685
30hindbrain development (GO:0030902)3.65044819
31asymmetric protein localization (GO:0008105)3.62976069
32cerebral cortex radially oriented cell migration (GO:0021799)3.58473160
33presynaptic membrane assembly (GO:0097105)3.57545931
34response to methylmercury (GO:0051597)3.55816398
35apical protein localization (GO:0045176)3.54114083
36astrocyte development (GO:0014002)3.45539215
37lateral sprouting from an epithelium (GO:0060601)3.35497759
38cilium movement (GO:0003341)3.33735191
39retinal ganglion cell axon guidance (GO:0031290)3.30882853
40neural tube formation (GO:0001841)3.28954273
41dorsal/ventral axis specification (GO:0009950)3.28549457
42smoothened signaling pathway (GO:0007224)3.28442410
43glycerophospholipid catabolic process (GO:0046475)3.28421639
44microtubule depolymerization (GO:0007019)3.26726428
45axon development (GO:0061564)3.24524989
46negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21258278
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.15400304
48neurotransmitter uptake (GO:0001504)3.13343015
49photoreceptor cell development (GO:0042461)3.12418344
50import into cell (GO:0098657)3.11139656
51left/right pattern formation (GO:0060972)3.11119750
52response to redox state (GO:0051775)3.10898745
53epithelial cilium movement (GO:0003351)3.09834430
54long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.09805834
55centriole replication (GO:0007099)3.08897244
56cellular component assembly involved in morphogenesis (GO:0010927)3.07662209
57myelination in peripheral nervous system (GO:0022011)3.06206870
58peripheral nervous system axon ensheathment (GO:0032292)3.06206870
59somite development (GO:0061053)3.05686419
60peptidyl-tyrosine autophosphorylation (GO:0038083)3.04412859
61axonemal dynein complex assembly (GO:0070286)3.02452384
62negative regulation of execution phase of apoptosis (GO:1900118)3.00220578
63amino acid import (GO:0043090)2.99703238
64GPI anchor biosynthetic process (GO:0006506)2.98736821
65left/right axis specification (GO:0070986)2.97109373
66protein polyglutamylation (GO:0018095)2.95023663
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94849301
68creatine metabolic process (GO:0006600)2.94189838
69adult walking behavior (GO:0007628)2.94008652
70regulation of microtubule-based movement (GO:0060632)2.91596204
71GPI anchor metabolic process (GO:0006505)2.89586227
72transmission of nerve impulse (GO:0019226)2.89412184
73short-term memory (GO:0007614)2.88780340
74cranial nerve development (GO:0021545)2.88578483
75neuron remodeling (GO:0016322)2.88344207
76membrane tubulation (GO:0097320)2.87840511
77otic vesicle formation (GO:0030916)2.85900045
78cholesterol biosynthetic process (GO:0006695)2.83629958
79resolution of meiotic recombination intermediates (GO:0000712)2.83469515
80microtubule bundle formation (GO:0001578)2.82067061
81preassembly of GPI anchor in ER membrane (GO:0016254)2.81968493
82long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.81857974
83substantia nigra development (GO:0021762)2.80522861
84neuronal action potential propagation (GO:0019227)2.80332779
85neuron recognition (GO:0008038)2.79586856
86eye photoreceptor cell development (GO:0042462)2.78871727
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77845227
88substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76968441
89substrate-independent telencephalic tangential migration (GO:0021826)2.76968441
90regulation of somitogenesis (GO:0014807)2.76345197
91magnesium ion transport (GO:0015693)2.75228317
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74065820
93protein palmitoylation (GO:0018345)2.73963881
94limb development (GO:0060173)2.73700014
95appendage development (GO:0048736)2.73700014
96positive regulation of neuroblast proliferation (GO:0002052)2.73645705
97pyrimidine nucleobase catabolic process (GO:0006208)2.71864922
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70741540
99microtubule polymerization or depolymerization (GO:0031109)2.67426018
100astrocyte differentiation (GO:0048708)2.67286856
101neuron fate determination (GO:0048664)2.67083193
102sterol biosynthetic process (GO:0016126)2.67042814
103protein complex biogenesis (GO:0070271)2.66517711
104negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64243936
105cell proliferation in forebrain (GO:0021846)2.64100213
106cilium or flagellum-dependent cell motility (GO:0001539)2.64023533
107regulation of glucokinase activity (GO:0033131)2.63997061
108regulation of hexokinase activity (GO:1903299)2.63997061
109fatty-acyl-CoA biosynthetic process (GO:0046949)2.62749937
110aldehyde catabolic process (GO:0046185)2.61138228
111positive regulation of glial cell differentiation (GO:0045687)2.61096076
112behavioral response to nicotine (GO:0035095)2.60419147
113regulation of lipoprotein metabolic process (GO:0050746)2.60235427
114pituitary gland development (GO:0021983)2.59419517
115organ growth (GO:0035265)2.58890031
116amyloid precursor protein metabolic process (GO:0042982)2.58728369
117photoreceptor cell maintenance (GO:0045494)2.57567197
118determination of left/right symmetry (GO:0007368)2.57351166
119regulation of feeding behavior (GO:0060259)2.57078576
120replication fork processing (GO:0031297)2.55776822
121synapsis (GO:0007129)2.55260816
122retina layer formation (GO:0010842)2.54133889
123isoprenoid biosynthetic process (GO:0008299)2.53375659
124protein neddylation (GO:0045116)2.53323532
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53122526
126ATP synthesis coupled proton transport (GO:0015986)2.53122526
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53113194
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.53113194
129NADH dehydrogenase complex assembly (GO:0010257)2.53113194
130dorsal/ventral pattern formation (GO:0009953)2.52690173
131negative regulation of axonogenesis (GO:0050771)2.52689210
132microtubule-based movement (GO:0007018)2.51470453
133positive regulation of cell fate commitment (GO:0010455)2.49355411
134negative regulation of inclusion body assembly (GO:0090084)2.49270236
135determination of bilateral symmetry (GO:0009855)2.49023523
136axonal fasciculation (GO:0007413)2.48223947
137regulation of dopamine metabolic process (GO:0042053)2.47965934
138regulation of catecholamine metabolic process (GO:0042069)2.47965934
139artery development (GO:0060840)2.46150680
140cerebellar granule cell differentiation (GO:0021707)2.45816724
141virion attachment to host cell (GO:0019062)2.45632672
142adhesion of symbiont to host cell (GO:0044650)2.45632672
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45616915
144nonmotile primary cilium assembly (GO:0035058)2.45341685
145ventricular system development (GO:0021591)2.44179876
146centriole assembly (GO:0098534)2.43959327
147cell projection assembly (GO:0030031)2.43603167
148negative regulation of axon guidance (GO:1902668)2.43134045
149specification of symmetry (GO:0009799)2.42944090
150axoneme assembly (GO:0035082)2.42632897
151spinal cord motor neuron differentiation (GO:0021522)2.42210098
152glial cell development (GO:0021782)2.41380300
153C4-dicarboxylate transport (GO:0015740)2.41272513
154mitochondrial respiratory chain complex assembly (GO:0033108)2.41165958
155very long-chain fatty acid metabolic process (GO:0000038)2.40848792
156positive regulation of action potential (GO:0045760)2.40512101
157platelet dense granule organization (GO:0060155)2.40445346
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.40213415
159postsynaptic membrane organization (GO:0001941)2.39340566
160fatty-acyl-CoA metabolic process (GO:0035337)2.38560623
161regulation of pigment cell differentiation (GO:0050932)2.36272438
162enteric nervous system development (GO:0048484)2.36225158
163sperm motility (GO:0030317)2.36142225
164regulation of oligodendrocyte differentiation (GO:0048713)2.35502935
165inner ear receptor stereocilium organization (GO:0060122)2.35375876
166peripheral nervous system development (GO:0007422)2.35055702
167positive regulation of cellular amine metabolic process (GO:0033240)2.34994309
168negative regulation of astrocyte differentiation (GO:0048712)2.34135511
169leukocyte migration involved in inflammatory response (GO:0002523)2.34099739
170olfactory bulb development (GO:0021772)2.33447127
171chaperone-mediated protein transport (GO:0072321)2.31350438
172startle response (GO:0001964)2.31121502
173response to pheromone (GO:0019236)2.29471328
174DNA damage response, detection of DNA damage (GO:0042769)2.29311845
175retinal rod cell development (GO:0046548)2.28283782
176retinal cone cell development (GO:0046549)2.26939357
177respiratory chain complex IV assembly (GO:0008535)2.23538503
178electron transport chain (GO:0022900)2.23348691
179DNA double-strand break processing (GO:0000729)2.22256501
180central nervous system myelination (GO:0022010)11.3231631
181axon ensheathment in central nervous system (GO:0032291)11.3231631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59996520
2GBX2_23144817_ChIP-Seq_PC3_Human3.45800812
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43424779
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42202248
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39461847
6TAF15_26573619_Chip-Seq_HEK293_Human2.37941973
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33126374
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.31120962
9EWS_26573619_Chip-Seq_HEK293_Human2.22028201
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.19057635
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17194975
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16544968
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16544968
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13893792
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12062473
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08861093
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07405247
18VDR_22108803_ChIP-Seq_LS180_Human2.04095211
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.03546219
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.03025863
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.99090473
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97382657
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.95913223
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95407540
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.89875168
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88656707
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84804628
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.83305917
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82833192
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82651398
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82233816
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78848587
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.77373960
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77295070
35AR_21572438_ChIP-Seq_LNCaP_Human1.76316149
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73397669
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70590813
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68156050
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66921264
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66123315
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65695814
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65314868
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64419325
44ER_23166858_ChIP-Seq_MCF-7_Human1.64101399
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61916100
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61759076
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61362997
48P300_19829295_ChIP-Seq_ESCs_Human1.60699802
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.58317413
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55655908
51DROSHA_22980978_ChIP-Seq_HELA_Human1.52615486
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50281938
53CBP_20019798_ChIP-Seq_JUKART_Human1.50281938
54BCAT_22108803_ChIP-Seq_LS180_Human1.48589240
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.47523371
56FUS_26573619_Chip-Seq_HEK293_Human1.43301894
57AR_25329375_ChIP-Seq_VCAP_Human1.41313044
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41105915
59MYC_18940864_ChIP-ChIP_HL60_Human1.34832747
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34748686
61RNF2_27304074_Chip-Seq_NSC_Mouse1.34730472
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34545505
63ELK1_19687146_ChIP-ChIP_HELA_Human1.32915766
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.30928468
65SMAD4_21799915_ChIP-Seq_A2780_Human1.29392870
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29022523
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28746921
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27673529
69IGF1R_20145208_ChIP-Seq_DFB_Human1.25678865
70REST_21632747_ChIP-Seq_MESCs_Mouse1.25338099
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24939251
72TCF4_22108803_ChIP-Seq_LS180_Human1.24350735
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22902977
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22407727
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.22374086
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21026568
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20433708
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.20423626
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19631901
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18902677
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18621496
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.16479400
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16245228
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15989413
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15331728
86* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15020642
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14925284
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14620469
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.14497485
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.11782601
91NANOG_19829295_ChIP-Seq_ESCs_Human1.11331495
92SOX2_19829295_ChIP-Seq_ESCs_Human1.11331495
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11082635
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10952160
95IRF1_19129219_ChIP-ChIP_H3396_Human1.10791832
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.09900874
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08273534
98* STAT3_23295773_ChIP-Seq_U87_Human1.08044657
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07853982
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07160543
101TP53_22573176_ChIP-Seq_HFKS_Human1.06450479
102AHR_22903824_ChIP-Seq_MCF-7_Human1.05785543
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.05627637
104P300_18555785_Chip-Seq_ESCs_Mouse1.05038950
105P53_22387025_ChIP-Seq_ESCs_Mouse1.04921799
106ZNF274_21170338_ChIP-Seq_K562_Hela1.04910551
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03924116
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03706397
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03375013
110TP53_18474530_ChIP-ChIP_U2OS_Human1.03333124
111SOX2_16153702_ChIP-ChIP_HESCs_Human1.01794338
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.01498267
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.01426958
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.00883065
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00085416
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.99862714
117* TCF4_23295773_ChIP-Seq_U87_Human0.99720229
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99309770
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99238077
120* RUNX2_22187159_ChIP-Seq_PCA_Human0.99207308
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.99167602
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97815161
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97815161
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.97784184
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97650713
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97061558
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97043113
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96729586
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96658109
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96075157
131TBL1_22424771_ChIP-Seq_293T_Human0.95661782
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.94859352
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94382507
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94382507
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.94153474
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93505401
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92833737
138KDM2B_26808549_Chip-Seq_REH_Human0.92675703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.01138957
2MP0003136_yellow_coat_color4.08216350
3MP0003880_abnormal_central_pattern3.98384971
4MP0000920_abnormal_myelination3.93191349
5MP0008789_abnormal_olfactory_epithelium3.53130544
6MP0002638_abnormal_pupillary_reflex3.48622325
7MP0004270_analgesia3.07470172
8MP0005394_taste/olfaction_phenotype2.90228078
9MP0005499_abnormal_olfactory_system2.90228078
10MP0003950_abnormal_plasma_membrane2.76468181
11MP0003690_abnormal_glial_cell2.72739791
12MP0008877_abnormal_DNA_methylation2.63515537
13MP0003787_abnormal_imprinting2.54401813
14MP0004885_abnormal_endolymph2.46935366
15MP0005171_absent_coat_pigmentation2.46712677
16MP0004742_abnormal_vestibular_system2.44683940
17MP0001486_abnormal_startle_reflex2.39182965
18MP0005410_abnormal_fertilization2.35781573
19MP0005423_abnormal_somatic_nervous2.34998770
20MP0001529_abnormal_vocalization2.31598809
21MP0000778_abnormal_nervous_system2.30511920
22MP0002272_abnormal_nervous_system2.27256950
23MP0005257_abnormal_intraocular_pressure2.25467589
24MP0001905_abnormal_dopamine_level2.18983481
25MP0001984_abnormal_olfaction2.13695096
26MP0001485_abnormal_pinna_reflex2.13566617
27MP0002064_seizures2.12153166
28MP0002102_abnormal_ear_morphology2.09164203
29MP0004142_abnormal_muscle_tone2.01997703
30MP0003329_amyloid_beta_deposits1.99952252
31MP0003634_abnormal_glial_cell1.99662022
32MP0009046_muscle_twitch1.95380076
33MP0004043_abnormal_pH_regulation1.92828380
34MP0004859_abnormal_synaptic_plasticity1.92582757
35MP0009745_abnormal_behavioral_response1.85538027
36MP0000566_synostosis1.85153660
37MP0003635_abnormal_synaptic_transmissio1.80177335
38MP0005409_darkened_coat_color1.79096863
39MP0005551_abnormal_eye_electrophysiolog1.76465536
40MP0001293_anophthalmia1.64266754
41MP0003121_genomic_imprinting1.63898171
42MP0001440_abnormal_grooming_behavior1.62444220
43MP0002734_abnormal_mechanical_nocicepti1.58235471
44MP0002234_abnormal_pharynx_morphology1.53377193
45MP0004381_abnormal_hair_follicle1.50202328
46MP0002572_abnormal_emotion/affect_behav1.50143242
47MP0000462_abnormal_digestive_system1.48895137
48MP0002229_neurodegeneration1.45746325
49MP0003122_maternal_imprinting1.43713094
50MP0005623_abnormal_meninges_morphology1.43092262
51MP0002160_abnormal_reproductive_system1.42038887
52MP0001963_abnormal_hearing_physiology1.41267076
53MP0002233_abnormal_nose_morphology1.40614941
54MP0002063_abnormal_learning/memory/cond1.40079218
55MP0002282_abnormal_trachea_morphology1.33954620
56MP0002653_abnormal_ependyma_morphology1.33868234
57MP0004134_abnormal_chest_morphology1.33715477
58MP0002882_abnormal_neuron_morphology1.33577915
59MP0001970_abnormal_pain_threshold1.32530646
60MP0010030_abnormal_orbit_morphology1.31881368
61MP0003938_abnormal_ear_development1.30392567
62MP0008569_lethality_at_weaning1.30157013
63MP0005646_abnormal_pituitary_gland1.28438355
64MP0008875_abnormal_xenobiotic_pharmacok1.28038195
65MP0001346_abnormal_lacrimal_gland1.26979583
66MP0001502_abnormal_circadian_rhythm1.25411817
67MP0002752_abnormal_somatic_nervous1.24734938
68MP0003632_abnormal_nervous_system1.24664027
69MP0002067_abnormal_sensory_capabilities1.24409677
70MP0001324_abnormal_eye_pigmentation1.23927845
71MP0000955_abnormal_spinal_cord1.22184804
72MP0004145_abnormal_muscle_electrophysio1.20644019
73MP0003633_abnormal_nervous_system1.19829070
74MP0001286_abnormal_eye_development1.19218604
75MP0002733_abnormal_thermal_nociception1.18253948
76MP0000569_abnormal_digit_pigmentation1.18035599
77MP0005253_abnormal_eye_physiology1.17421188
78MP0003890_abnormal_embryonic-extraembry1.17331332
79MP0000383_abnormal_hair_follicle1.17036376
80MP0003631_nervous_system_phenotype1.16868053
81MP0005391_vision/eye_phenotype1.16591775
82MP0003755_abnormal_palate_morphology1.15885684
83MP0010678_abnormal_skin_adnexa1.15701292
84MP0000026_abnormal_inner_ear1.15567563
85MP0004147_increased_porphyrin_level1.13202676
86MP0002751_abnormal_autonomic_nervous1.12875071
87MP0002697_abnormal_eye_size1.12646026
88MP0008058_abnormal_DNA_repair1.11488785
89MP0008260_abnormal_autophagy1.10204099
90MP0003011_delayed_dark_adaptation1.09408560
91MP0001501_abnormal_sleep_pattern1.09045525
92MP0003937_abnormal_limbs/digits/tail_de1.08412789
93MP0009250_abnormal_appendicular_skeleto1.07967504
94MP0001968_abnormal_touch/_nociception1.07693881
95MP0005195_abnormal_posterior_eye1.07632977
96MP0005248_abnormal_Harderian_gland1.07292982
97MP0002066_abnormal_motor_capabilities/c1.06957636
98MP0000372_irregular_coat_pigmentation1.04122645
99MP0005084_abnormal_gallbladder_morpholo1.03864779
100MP0001299_abnormal_eye_distance/1.03717145
101MP0000613_abnormal_salivary_gland1.03625596
102MP0006072_abnormal_retinal_apoptosis1.03027838
103MP0000647_abnormal_sebaceous_gland1.02987926
104MP0002822_catalepsy1.02925059
105MP0000631_abnormal_neuroendocrine_gland1.02496258
106MP0002557_abnormal_social/conspecific_i0.99924367
107MP0005386_behavior/neurological_phenoty0.97225963
108MP0004924_abnormal_behavior0.97225963
109MP0002928_abnormal_bile_duct0.95920833
110MP0002938_white_spotting0.95501316
111MP0000762_abnormal_tongue_morphology0.93270947
112MP0002152_abnormal_brain_morphology0.92445323
113MP0006276_abnormal_autonomic_nervous0.91493986
114MP0004133_heterotaxia0.89898016
115MP0003718_maternal_effect0.87657810
116MP0005389_reproductive_system_phenotype0.87484312
117MP0002736_abnormal_nociception_after0.86474847
118MP0001851_eye_inflammation0.85900548
119MP0003137_abnormal_impulse_conducting0.85677780
120MP0003119_abnormal_digestive_system0.85525563
121MP0002184_abnormal_innervation0.85273352
122MP0000049_abnormal_middle_ear0.85133938
123MP0010386_abnormal_urinary_bladder0.85074851
124MP0000604_amyloidosis0.84206973
125MP0005187_abnormal_penis_morphology0.83189450
126MP0001929_abnormal_gametogenesis0.82072902
127MP0002092_abnormal_eye_morphology0.80950672
128MP0002735_abnormal_chemical_nociception0.80254384
129MP0003698_abnormal_male_reproductive0.79854662
130MP0002295_abnormal_pulmonary_circulatio0.77916073
131MP0005645_abnormal_hypothalamus_physiol0.75370761
132MP0002210_abnormal_sex_determination0.75223717
133MP0003195_calcinosis0.72086937
134MP0002249_abnormal_larynx_morphology0.71843281
135MP0001177_atelectasis0.71621107
136MP0001188_hyperpigmentation0.71533899
137MP0009384_cardiac_valve_regurgitation0.70839355
138MP0001986_abnormal_taste_sensitivity0.70480442
139MP0003935_abnormal_craniofacial_develop0.69626609
140MP0005377_hearing/vestibular/ear_phenot0.69438342
141MP0003878_abnormal_ear_physiology0.69438342
142MP0000467_abnormal_esophagus_morphology0.67975048
143MP0000537_abnormal_urethra_morphology0.67868331
144MP0001340_abnormal_eyelid_morphology0.65411857
145MP0000579_abnormal_nail_morphology0.65092150
146MP0003861_abnormal_nervous_system0.63283225
147MP0001661_extended_life_span0.61567335

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.33472082
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.97824545
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.97824545
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.51992088
5Pancreatic cysts (HP:0001737)4.07652920
6Peripheral hypomyelination (HP:0007182)4.03362463
7Molar tooth sign on MRI (HP:0002419)3.98353406
8Abnormality of midbrain morphology (HP:0002418)3.98353406
9Parakeratosis (HP:0001036)3.93410654
10Abnormal respiratory motile cilium physiology (HP:0012261)3.93269009
11Abnormal ciliary motility (HP:0012262)3.89520307
12Hypoplasia of the fovea (HP:0007750)3.81063594
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.81063594
14Nephronophthisis (HP:0000090)3.77155723
15Cerebral inclusion bodies (HP:0100314)3.72748716
16Abnormality of the corticospinal tract (HP:0002492)3.44056200
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.39519569
18Absent/shortened dynein arms (HP:0200106)3.39519569
19Abnormality of the fovea (HP:0000493)3.35133282
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.32628663
21Chronic bronchitis (HP:0004469)3.26599710
22Aplasia involving bones of the upper limbs (HP:0009823)3.23112545
23Aplasia of the phalanges of the hand (HP:0009802)3.23112545
24Aplasia involving bones of the extremities (HP:0009825)3.23112545
25Abnormal respiratory motile cilium morphology (HP:0005938)3.08829634
26Abnormal respiratory epithelium morphology (HP:0012253)3.08829634
27Synostosis involving the elbow (HP:0003938)3.08082688
28Humeroradial synostosis (HP:0003041)3.08082688
29Cystic liver disease (HP:0006706)3.07229597
30Abnormality of the renal medulla (HP:0100957)3.06001843
31Split foot (HP:0001839)3.02508770
32Onion bulb formation (HP:0003383)2.98338149
33Chronic hepatic failure (HP:0100626)2.96170588
34Occipital encephalocele (HP:0002085)2.95684209
35Bronchiectasis (HP:0002110)2.86933996
36Retinal dysplasia (HP:0007973)2.78902530
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.74433482
38Postaxial foot polydactyly (HP:0001830)2.74104206
39Optic nerve hypoplasia (HP:0000609)2.73037950
40Genital tract atresia (HP:0001827)2.67909681
41Abnormality of the middle phalanges of the toes (HP:0010183)2.65865619
42Anencephaly (HP:0002323)2.65843354
43Rhinitis (HP:0012384)2.65405270
44Sensory axonal neuropathy (HP:0003390)2.65027265
45Supranuclear gaze palsy (HP:0000605)2.64550395
46Absent septum pellucidum (HP:0001331)2.62702123
47Vaginal atresia (HP:0000148)2.61929546
48Congenital hepatic fibrosis (HP:0002612)2.61130154
49Sclerocornea (HP:0000647)2.60831570
50Alacrima (HP:0000522)2.59267410
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55246684
52Dysmetria (HP:0001310)2.54930162
53Leukodystrophy (HP:0002415)2.54656500
54Spastic gait (HP:0002064)2.53995335
55Medial flaring of the eyebrow (HP:0010747)2.53858435
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53750910
57Thickened helices (HP:0000391)2.49410029
58Intention tremor (HP:0002080)2.45687644
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43016400
60Hypoplastic pelvis (HP:0008839)2.42598470
61Tubulointerstitial nephritis (HP:0001970)2.42080053
62Postaxial hand polydactyly (HP:0001162)2.41984965
63Tubular atrophy (HP:0000092)2.40677567
64Gait imbalance (HP:0002141)2.37059459
65Optic nerve coloboma (HP:0000588)2.35168305
66Metabolic alkalosis (HP:0200114)2.33004041
67Hypoplasia of the iris (HP:0007676)2.31372716
68Anteriorly placed anus (HP:0001545)2.30795992
69Anophthalmia (HP:0000528)2.30336316
70Coronal craniosynostosis (HP:0004440)2.29795465
71Hypomagnesemia (HP:0002917)2.29345513
72Male pseudohermaphroditism (HP:0000037)2.28865721
73Myokymia (HP:0002411)2.26968342
74Abnormality of the septum pellucidum (HP:0007375)2.26048770
75Abnormal auditory evoked potentials (HP:0006958)2.26023020
76Cerebral hypomyelination (HP:0006808)2.24124831
77Aplasia/Hypoplasia of the macula (HP:0008059)2.23935375
78Poor coordination (HP:0002370)2.23558308
79Megalencephaly (HP:0001355)2.22265697
80Oligodactyly (hands) (HP:0001180)2.20034212
81Clumsiness (HP:0002312)2.19971754
82Abnormality of the labia minora (HP:0012880)2.19664734
83Congenital primary aphakia (HP:0007707)2.19139991
84Preaxial hand polydactyly (HP:0001177)2.19104555
85Scanning speech (HP:0002168)2.18263255
86Septo-optic dysplasia (HP:0100842)2.14541345
87Focal motor seizures (HP:0011153)2.14194530
88Ankle clonus (HP:0011448)2.13964148
89Acute encephalopathy (HP:0006846)2.11567553
90Congenital ichthyosiform erythroderma (HP:0007431)2.10619373
91Abnormality of the renal cortex (HP:0011035)2.08506699
92Patchy hypopigmentation of hair (HP:0011365)2.07257075
93White forelock (HP:0002211)2.06755220
94Long nose (HP:0003189)2.06683078
95Abolished electroretinogram (ERG) (HP:0000550)2.06620127
96Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05956077
97Morphological abnormality of the inner ear (HP:0011390)2.05073733
98Median cleft lip (HP:0000161)2.03765788
99Bile duct proliferation (HP:0001408)2.02160550
100Abnormal biliary tract physiology (HP:0012439)2.02160550
101Decreased lacrimation (HP:0000633)2.01893817
102Intestinal atresia (HP:0011100)2.00672080
103Oculomotor apraxia (HP:0000657)1.99742328
104Cupped ear (HP:0000378)1.99598435
105Segmental peripheral demyelination/remyelination (HP:0003481)1.99228397
106Nephrogenic diabetes insipidus (HP:0009806)1.98333583
107Narrow forehead (HP:0000341)1.98237788
108Adrenal hypoplasia (HP:0000835)1.97557341
109Bifid tongue (HP:0010297)1.96807114
110Increased circulating renin level (HP:0000848)1.96774426
111Decreased central vision (HP:0007663)1.96370635
112Hip dysplasia (HP:0001385)1.96075688
113Hemiparesis (HP:0001269)1.95294438
114Progressive macrocephaly (HP:0004481)1.94214152
115Broad-based gait (HP:0002136)1.93533329
116Symphalangism affecting the phalanges of the hand (HP:0009773)1.92006252
117Aplasia/Hypoplasia of the lens (HP:0008063)1.91600575
118Mitochondrial inheritance (HP:0001427)1.91520995
119True hermaphroditism (HP:0010459)1.90303990
120Abnormal mitochondria in muscle tissue (HP:0008316)1.88593682
121Slow saccadic eye movements (HP:0000514)1.87642635
122Bell-shaped thorax (HP:0001591)1.86158411
123Lower limb muscle weakness (HP:0007340)1.84757029
124Esophageal atresia (HP:0002032)1.84490349
125Aganglionic megacolon (HP:0002251)1.83634273
126Partial duplication of thumb phalanx (HP:0009944)1.83482644
127Short hallux (HP:0010109)1.80712844
128Abnormality of magnesium homeostasis (HP:0004921)1.80224364
129Abnormal rod and cone electroretinograms (HP:0008323)1.79872616
130Furrowed tongue (HP:0000221)1.79531244
131Hypoplastic left heart (HP:0004383)1.79088469
132Diplopia (HP:0000651)1.78430720
133Abnormality of binocular vision (HP:0011514)1.78430720
134Broad foot (HP:0001769)1.78339119
135Keratoconus (HP:0000563)1.78004003
136Increased corneal curvature (HP:0100692)1.78004003
137Pancreatic fibrosis (HP:0100732)1.77383767
138Abnormality of the axillary hair (HP:0100134)1.76220564
139Abnormality of secondary sexual hair (HP:0009888)1.76220564
140Hypokalemic alkalosis (HP:0001949)1.75238375
141Mixed hearing impairment (HP:0000410)1.75183301
142Epileptic encephalopathy (HP:0200134)1.74960374
143Termporal pattern (HP:0011008)1.74607699
144Insidious onset (HP:0003587)1.74607699
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74098806
146Hyperventilation (HP:0002883)1.73824606
147Duplicated collecting system (HP:0000081)1.73600866
148Congenital stationary night blindness (HP:0007642)1.73268066
149Supernumerary spleens (HP:0009799)1.73146608
150Type II lissencephaly (HP:0007260)1.72958161
151Duplication of thumb phalanx (HP:0009942)1.72918002
152Increased CSF lactate (HP:0002490)1.72485999
153Acute necrotizing encephalopathy (HP:0006965)1.72066957
154Dandy-Walker malformation (HP:0001305)1.71578717
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70564626
156Pendular nystagmus (HP:0012043)1.70490182
157Asplenia (HP:0001746)1.70381089
158Holoprosencephaly (HP:0001360)1.69253404
159Abnormality of macular pigmentation (HP:0008002)1.69240413
160Specific learning disability (HP:0001328)1.68940457
161Nasal polyposis (HP:0100582)1.67272800
162Tubulointerstitial abnormality (HP:0001969)1.67123267
163Prominent nasal bridge (HP:0000426)1.66633683
164Astigmatism (HP:0000483)1.66124105
165Hyperglycinemia (HP:0002154)1.64805353
166Cerebral edema (HP:0002181)1.63709052
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.62479022
168Chronic sinusitis (HP:0011109)1.60261980
169Colon cancer (HP:0003003)1.60208684
170Congenital, generalized hypertrichosis (HP:0004540)1.58708309
171Abnormal drinking behavior (HP:0030082)1.57540200
172Polydipsia (HP:0001959)1.57540200
173Oligodactyly (HP:0012165)1.56595087
174Growth hormone deficiency (HP:0000824)1.52761723
175Iris coloboma (HP:0000612)1.52754823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.35836579
2OXSR13.85373541
3WNK33.19825441
4CASK2.82086540
5FRK2.80426239
6FGFR22.73761397
7PNCK2.59293943
8MAPK152.51054626
9PKN12.46905940
10EPHB12.42813695
11BCR2.42147116
12WEE12.20596353
13MAP3K42.19376998
14TRIM282.15836305
15TNIK2.07396219
16MAPKAPK52.07147562
17WNK41.87928030
18MUSK1.82355627
19CDK191.77158703
20MAP4K21.76287839
21VRK21.69866445
22PBK1.68821826
23CAMK2B1.68392801
24NUAK11.66116869
25MST41.61824100
26NTRK21.60104166
27NEK61.57533879
28CSNK1G31.56977239
29LIMK11.56569389
30UHMK11.55551352
31NEK11.55338134
32ROCK21.52977286
33WNK11.51277399
34MET1.51183352
35CSNK1A1L1.50328356
36ZAK1.49908448
37VRK11.40542986
38FGR1.37878591
39CAMK2D1.34937636
40EPHA41.31502540
41MKNK21.30342657
42DYRK31.30036418
43CSNK1G11.29010635
44EPHB21.28462730
45ACVR1B1.28380925
46TESK21.28095153
47BCKDK1.26457884
48CSNK1G21.25430247
49MARK11.22418530
50SGK4941.18819854
51SGK2231.18819854
52ERBB31.18606261
53SRPK11.17450301
54PLK31.14997029
55STK38L1.14017026
56DYRK21.13699521
57NTRK11.13603427
58CLK11.11273274
59BRSK21.08119075
60INSRR1.06709969
61PHKG21.01858340
62PHKG11.01858340
63BUB11.01502953
64CAMK2A1.01374544
65MARK21.01051522
66PRKCE1.00465854
67ICK1.00376118
68PLK40.99427082
69CAMK2G0.99369482
70TTK0.98251751
71BMPR1B0.94045243
72MKNK10.91198279
73NEK20.90523820
74CDC70.89219290
75STK160.88837021
76CCNB10.84392435
77MAPK130.83661038
78PLK10.83533035
79TGFBR10.81662735
80PAK60.81567268
81ARAF0.79932064
82GRK10.79901361
83PRPF4B0.76829021
84CDK50.75885149
85CDK30.74897823
86TYRO30.74500740
87BLK0.71752335
88STK30.70096030
89PRKD10.67427818
90DMPK0.66551954
91EIF2AK30.65647158
92ERBB40.65300252
93PRKCQ0.64723830
94ADRBK20.63561263
95TSSK60.63102834
96MINK10.62350181
97CDK140.61896186
98PRKG10.61702748
99CAMK1G0.61615894
100MAP2K20.61341706
101PTK2B0.61133716
102TAF10.59722356
103PAK30.59199757
104PINK10.58733090
105ADRBK10.57020887
106DYRK1A0.55131208
107CDK180.51981309
108GSK3A0.51735513
109CDK150.51187240
110STK240.50631276
111CSNK1D0.49204096
112TRPM70.48997475
113IRAK10.48944113
114PIK3CA0.48930404
115MAPK70.48718359
116RPS6KA50.47786712
117FER0.47530406
118CSNK1A10.46403301
119BMPR20.45791449
120PDPK10.45321199
121FYN0.45177104
122NME10.45059666
123CDK11A0.44047333
124PRKACA0.42953708
125CHEK20.42386331
126FES0.42300982
127MAP2K70.41343408
128PRKACB0.40806897
129LATS10.40762098
130PLK20.39019878
131BRSK10.37817077
132PRKCG0.36974351
133HIPK20.36793302
134GRK50.36479586
135MAPK120.36067249
136GRK70.35255814
137EPHA20.34638043
138ATM0.34322988
139TIE10.32249847
140DDR20.32078990
141SIK30.31071369
142ATR0.30347646
143TLK10.29958445
144ERBB20.29348338
145AKT30.28521562
146EIF2AK10.28505563
147SGK20.28482036
148NTRK30.28376225
149PRKCH0.28024615
150CSNK1E0.27953666
151MAP2K40.27463532
152FGFR10.27414721
153AURKB0.27361427

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.99186683
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.72098307
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95930837
4Steroid biosynthesis_Homo sapiens_hsa001002.88215654
5Ether lipid metabolism_Homo sapiens_hsa005652.84680876
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35398851
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29857114
8Oxidative phosphorylation_Homo sapiens_hsa001902.01450908
9Fanconi anemia pathway_Homo sapiens_hsa034602.01232530
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.00135894
11Sulfur metabolism_Homo sapiens_hsa009201.86812064
12Propanoate metabolism_Homo sapiens_hsa006401.85939760
13GABAergic synapse_Homo sapiens_hsa047271.84355147
14Vitamin B6 metabolism_Homo sapiens_hsa007501.83517723
15Glutamatergic synapse_Homo sapiens_hsa047241.74387029
16Sphingolipid metabolism_Homo sapiens_hsa006001.73171527
17Protein export_Homo sapiens_hsa030601.72153012
18Axon guidance_Homo sapiens_hsa043601.70367175
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68894257
20Proteasome_Homo sapiens_hsa030501.65115450
21Nicotine addiction_Homo sapiens_hsa050331.64483620
22Homologous recombination_Homo sapiens_hsa034401.61265688
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59134922
24Histidine metabolism_Homo sapiens_hsa003401.58146725
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57336427
26Basal transcription factors_Homo sapiens_hsa030221.57335178
27Serotonergic synapse_Homo sapiens_hsa047261.55793480
28Nitrogen metabolism_Homo sapiens_hsa009101.54266992
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50802151
30Ribosome_Homo sapiens_hsa030101.50373440
31Non-homologous end-joining_Homo sapiens_hsa034501.49434951
32RNA polymerase_Homo sapiens_hsa030201.47226635
33Linoleic acid metabolism_Homo sapiens_hsa005911.46021942
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45726826
35Alzheimers disease_Homo sapiens_hsa050101.42175679
36Phototransduction_Homo sapiens_hsa047441.39667840
37Morphine addiction_Homo sapiens_hsa050321.37084396
38Chemical carcinogenesis_Homo sapiens_hsa052041.35481347
39RNA degradation_Homo sapiens_hsa030181.32517444
40Parkinsons disease_Homo sapiens_hsa050121.31969533
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24034996
42Taste transduction_Homo sapiens_hsa047421.23406452
43Long-term depression_Homo sapiens_hsa047301.21164465
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19559076
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19327038
46Circadian entrainment_Homo sapiens_hsa047131.17997996
47Mismatch repair_Homo sapiens_hsa034301.16939309
48Cocaine addiction_Homo sapiens_hsa050301.15361050
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14547004
50Dorso-ventral axis formation_Homo sapiens_hsa043201.09633134
51Collecting duct acid secretion_Homo sapiens_hsa049661.07309875
52beta-Alanine metabolism_Homo sapiens_hsa004101.07051434
53Peroxisome_Homo sapiens_hsa041461.05205029
54Salivary secretion_Homo sapiens_hsa049701.02825131
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00546122
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.98518962
57Gastric acid secretion_Homo sapiens_hsa049710.97615062
58Fatty acid biosynthesis_Homo sapiens_hsa000610.97388433
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96795755
60Huntingtons disease_Homo sapiens_hsa050160.95698769
61Mineral absorption_Homo sapiens_hsa049780.95139033
62Caffeine metabolism_Homo sapiens_hsa002320.94975661
63Arachidonic acid metabolism_Homo sapiens_hsa005900.94727217
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94515207
65Vibrio cholerae infection_Homo sapiens_hsa051100.93056505
66Renal cell carcinoma_Homo sapiens_hsa052110.91908207
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91599915
68Arginine and proline metabolism_Homo sapiens_hsa003300.90812854
69Butanoate metabolism_Homo sapiens_hsa006500.89862991
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.89616691
71Nucleotide excision repair_Homo sapiens_hsa034200.89315763
72Cardiac muscle contraction_Homo sapiens_hsa042600.89154177
73Dopaminergic synapse_Homo sapiens_hsa047280.88553574
74Pyruvate metabolism_Homo sapiens_hsa006200.85339401
75Tyrosine metabolism_Homo sapiens_hsa003500.84557979
76Hippo signaling pathway_Homo sapiens_hsa043900.83505110
77Tryptophan metabolism_Homo sapiens_hsa003800.82414210
78RNA transport_Homo sapiens_hsa030130.81703772
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81464664
80Rheumatoid arthritis_Homo sapiens_hsa053230.81343674
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.80060693
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79852473
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.79828184
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78881417
85Regulation of autophagy_Homo sapiens_hsa041400.78186756
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77863347
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77740136
88Renin secretion_Homo sapiens_hsa049240.76860871
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.76695653
90Folate biosynthesis_Homo sapiens_hsa007900.76480479
91Pancreatic secretion_Homo sapiens_hsa049720.75334945
92Ras signaling pathway_Homo sapiens_hsa040140.74976325
93Cholinergic synapse_Homo sapiens_hsa047250.74199162
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72979155
95Hedgehog signaling pathway_Homo sapiens_hsa043400.72452560
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70847287
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69664373
98Amphetamine addiction_Homo sapiens_hsa050310.68471878
99Base excision repair_Homo sapiens_hsa034100.68299492
100Autoimmune thyroid disease_Homo sapiens_hsa053200.68297307
101Ovarian steroidogenesis_Homo sapiens_hsa049130.67865098
102Purine metabolism_Homo sapiens_hsa002300.67487397
103cAMP signaling pathway_Homo sapiens_hsa040240.67437674
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66377758
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.65552125
106Tight junction_Homo sapiens_hsa045300.65239286
107Pyrimidine metabolism_Homo sapiens_hsa002400.64652605
108Insulin secretion_Homo sapiens_hsa049110.64035144
109Oocyte meiosis_Homo sapiens_hsa041140.63385553
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62968840
111Fatty acid degradation_Homo sapiens_hsa000710.62071090
112Circadian rhythm_Homo sapiens_hsa047100.59426353
113Synaptic vesicle cycle_Homo sapiens_hsa047210.58341109
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.57059971
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56863062
116Spliceosome_Homo sapiens_hsa030400.56325604
117Calcium signaling pathway_Homo sapiens_hsa040200.55847652
118Fatty acid metabolism_Homo sapiens_hsa012120.54853664
119ErbB signaling pathway_Homo sapiens_hsa040120.53405218
120Phenylalanine metabolism_Homo sapiens_hsa003600.51629890
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51169862
122Glutathione metabolism_Homo sapiens_hsa004800.50613720
123Melanogenesis_Homo sapiens_hsa049160.49991893
124Glycerolipid metabolism_Homo sapiens_hsa005610.48257654
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47872949
126TGF-beta signaling pathway_Homo sapiens_hsa043500.47835813
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47024856
128Choline metabolism in cancer_Homo sapiens_hsa052310.46828410
129One carbon pool by folate_Homo sapiens_hsa006700.46811171
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46084559
131Phagosome_Homo sapiens_hsa041450.45922953
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45746938
133Malaria_Homo sapiens_hsa051440.45716364
134Wnt signaling pathway_Homo sapiens_hsa043100.45207655
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44916627
136Gap junction_Homo sapiens_hsa045400.43596724
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40858237
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40726077
139Endocytosis_Homo sapiens_hsa041440.39270626
140Metabolic pathways_Homo sapiens_hsa011000.36544235
141Long-term potentiation_Homo sapiens_hsa047200.35415140
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35091419
143Retinol metabolism_Homo sapiens_hsa008300.34699144
144ECM-receptor interaction_Homo sapiens_hsa045120.33638942
145Basal cell carcinoma_Homo sapiens_hsa052170.32832426
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32719508
147Olfactory transduction_Homo sapiens_hsa047400.31836346

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