IQGAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.92162690
2daunorubicin metabolic process (GO:0044597)6.54925797
3polyketide metabolic process (GO:0030638)6.54925797
4doxorubicin metabolic process (GO:0044598)6.54925797
5mitotic sister chromatid segregation (GO:0000070)6.12576427
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.50537816
7protein localization to chromosome, centromeric region (GO:0071459)5.48126480
8sister chromatid segregation (GO:0000819)5.47900017
9regulation of telomere maintenance via telomerase (GO:0032210)5.30024670
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.07618206
11nuclear pore complex assembly (GO:0051292)4.99345601
12regulation of mitotic spindle organization (GO:0060236)4.90383557
13DNA replication-dependent nucleosome assembly (GO:0006335)4.80565186
14DNA replication-dependent nucleosome organization (GO:0034723)4.80565186
15DNA replication checkpoint (GO:0000076)4.77529947
16nuclear pore organization (GO:0006999)4.68716190
17negative regulation of cell cycle G2/M phase transition (GO:1902750)4.63250873
18mitotic chromosome condensation (GO:0007076)4.62708575
19negative regulation of epidermis development (GO:0045683)4.49803813
20heterochromatin organization (GO:0070828)4.45179266
21positive regulation of DNA-dependent DNA replication (GO:2000105)4.38822059
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.35210427
23negative regulation of telomerase activity (GO:0051974)4.34780116
24telomere maintenance via semi-conservative replication (GO:0032201)4.31612335
25maintenance of protein location in nucleus (GO:0051457)4.26843495
26histone H4-K8 acetylation (GO:0043982)4.21386143
27histone H4-K5 acetylation (GO:0043981)4.21386143
28DNA unwinding involved in DNA replication (GO:0006268)4.16261232
29histone H4-K12 acetylation (GO:0043983)4.16066214
30DNA topological change (GO:0006265)4.13255780
31chromatin assembly (GO:0031497)4.09444322
32somite rostral/caudal axis specification (GO:0032525)4.05185946
33notochord development (GO:0030903)4.03276671
34regulation of response to osmotic stress (GO:0047484)4.00716712
35mitotic sister chromatid cohesion (GO:0007064)4.00544684
36aminoglycoside antibiotic metabolic process (GO:0030647)3.98933582
37negative regulation of telomere maintenance (GO:0032205)3.91763134
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.90368715
39pore complex assembly (GO:0046931)3.90214140
40rRNA transcription (GO:0009303)3.86222247
41positive regulation of chromosome segregation (GO:0051984)3.82032133
42regulation of translational fidelity (GO:0006450)3.78777469
43regulation of sister chromatid cohesion (GO:0007063)3.78466425
44DNA replication initiation (GO:0006270)3.77257131
45negative regulation of epidermal cell differentiation (GO:0045605)3.64986310
46rRNA methylation (GO:0031167)3.64104285
47telomere maintenance via recombination (GO:0000722)3.63422404
48mitotic metaphase plate congression (GO:0007080)3.61938631
49DNA duplex unwinding (GO:0032508)3.61125146
50rRNA modification (GO:0000154)3.60804630
51DNA geometric change (GO:0032392)3.60325139
52regulation of translation in response to stress (GO:0043555)3.60219610
53spindle assembly involved in mitosis (GO:0090307)3.55005501
54attachment of spindle microtubules to kinetochore (GO:0008608)3.52228031
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50934991
56mitotic cytokinesis (GO:0000281)3.45970184
57mitotic nuclear envelope disassembly (GO:0007077)3.41940068
58protein localization to chromosome (GO:0034502)3.36776485
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35586286
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35586286
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.35586286
62mitotic G2/M transition checkpoint (GO:0044818)3.33072356
63muscle organ morphogenesis (GO:0048644)3.32603985
64regulation of telomere maintenance (GO:0032204)3.31568514
65regulation of DNA-dependent DNA replication (GO:0090329)3.30369738
66kinetochore organization (GO:0051383)3.30001032
67regulation of MHC class I biosynthetic process (GO:0045343)3.29340654
68regulation of centrosome cycle (GO:0046605)3.27480064
69chromosome condensation (GO:0030261)3.25432924
70spindle assembly (GO:0051225)3.24982621
71chromatin assembly or disassembly (GO:0006333)3.24019853
72microtubule depolymerization (GO:0007019)3.23653382
73regulation of double-strand break repair (GO:2000779)3.20065080
74pre-miRNA processing (GO:0031054)3.20063595
75* regulation of mammary gland epithelial cell proliferation (GO:0033599)3.18922510
76regulation of centriole replication (GO:0046599)3.16922364
77chromosome segregation (GO:0007059)3.16156140
78nuclear envelope organization (GO:0006998)3.12820320
79nuclear envelope disassembly (GO:0051081)3.12668555
80membrane disassembly (GO:0030397)3.12668555
81formation of translation preinitiation complex (GO:0001731)3.11614415
82protein complex localization (GO:0031503)3.11603888
83DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.11559195
84metaphase plate congression (GO:0051310)3.11151114
85histone H4-K16 acetylation (GO:0043984)3.09455654
86cell fate commitment involved in formation of primary germ layer (GO:0060795)3.08081451
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.07880209
88spindle assembly checkpoint (GO:0071173)3.07716557
89DNA conformation change (GO:0071103)3.07218011
90DNA damage response, detection of DNA damage (GO:0042769)3.06999019
91regulation of gene silencing by RNA (GO:0060966)3.06481203
92regulation of posttranscriptional gene silencing (GO:0060147)3.06481203
93regulation of gene silencing by miRNA (GO:0060964)3.06481203
94establishment of mitotic spindle localization (GO:0040001)3.06468112
95DNA ligation (GO:0006266)3.06402945
96ribosome biogenesis (GO:0042254)3.06134301
97spindle organization (GO:0007051)3.06050219
98branching involved in mammary gland duct morphogenesis (GO:0060444)3.05655142
99spindle checkpoint (GO:0031577)3.04365128
100microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.03791067
101mRNA stabilization (GO:0048255)3.00589182
102RNA stabilization (GO:0043489)3.00589182
103kinetochore assembly (GO:0051382)2.98386950
104regulation of mitotic sister chromatid separation (GO:0010965)2.97694824
105regulation of mitotic sister chromatid segregation (GO:0033047)2.97694824
106regulation of sister chromatid segregation (GO:0033045)2.97694824
107mitotic spindle checkpoint (GO:0071174)2.96609067
108DNA synthesis involved in DNA repair (GO:0000731)2.95998837
109regulation of chromosome segregation (GO:0051983)2.95402773
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94194213
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94194213
112DNA strand elongation involved in DNA replication (GO:0006271)2.93661338
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.92072601
114regulation of DNA endoreduplication (GO:0032875)2.91939273
115CENP-A containing nucleosome assembly (GO:0034080)2.91756578
116ventricular cardiac muscle cell development (GO:0055015)2.91626315
117meiotic chromosome segregation (GO:0045132)2.90673347
118mitotic spindle assembly checkpoint (GO:0007094)2.89483012
119mitotic recombination (GO:0006312)2.89273946
120protein K6-linked ubiquitination (GO:0085020)2.88837626
121negative regulation of chromosome segregation (GO:0051985)2.88036439
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87400524
123chromatin remodeling at centromere (GO:0031055)2.86225374
124DNA replication-independent nucleosome organization (GO:0034724)2.84373397
125DNA replication-independent nucleosome assembly (GO:0006336)2.84373397
126establishment of integrated proviral latency (GO:0075713)2.83356639
127regulation of spindle organization (GO:0090224)2.82980307
128regulation of centrosome duplication (GO:0010824)2.82829426
129mitotic spindle organization (GO:0007052)2.82142094
130activation of Rac GTPase activity (GO:0032863)2.81647174
131cytoskeleton-dependent cytokinesis (GO:0061640)2.81175310
132DNA damage response, signal transduction resulting in transcription (GO:0042772)2.80722711
133regulation of telomerase activity (GO:0051972)2.80716069
134establishment of chromosome localization (GO:0051303)2.80322169
135mitotic cell cycle (GO:0000278)2.80130357
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.79965294
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79965294
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79965294
139negative regulation of sister chromatid segregation (GO:0033046)2.79965294
140DNA strand elongation (GO:0022616)2.79437622
141DNA packaging (GO:0006323)2.79261740
142telomere maintenance via telomere lengthening (GO:0010833)2.78058378
143cellular protein complex localization (GO:0034629)2.76709370
144chromosome organization (GO:0051276)2.75822634
145double-strand break repair via nonhomologous end joining (GO:0006303)2.73987439
146non-recombinational repair (GO:0000726)2.73987439
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73060355
148nucleobase-containing small molecule interconversion (GO:0015949)2.72502559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75749254
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.25776616
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.60104014
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.60104014
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.60104014
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10414030
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.94438188
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44632523
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38049641
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.93815869
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.81462678
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55623601
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32896889
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28125536
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.27396588
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17864882
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15836267
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14662322
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08157884
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.02031063
21TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01725441
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00673350
23TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98354876
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98073213
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97747042
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92332364
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92076843
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88660389
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88004489
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86168864
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82441231
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81550894
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74964886
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73420420
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.71955747
36NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70451847
37* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70148256
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68259592
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67496590
40ZNF263_19887448_ChIP-Seq_K562_Human1.63810560
41* AR_21909140_ChIP-Seq_LNCAP_Human1.60056270
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59794974
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58127701
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57778744
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56292316
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53594864
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50902350
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48434379
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.47668017
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.45384365
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.39363022
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37728634
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37129304
54IRF1_19129219_ChIP-ChIP_H3396_Human1.34370637
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32696790
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32395924
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30769285
58XRN2_22483619_ChIP-Seq_HELA_Human1.30744708
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30539045
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29730262
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.29327187
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28837395
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26802268
64FOXP3_21729870_ChIP-Seq_TREG_Human1.26141013
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25215831
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23228947
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22674608
68MYC_22102868_ChIP-Seq_BL_Human1.22181841
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21693376
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21079523
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21030814
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20269777
73* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18545884
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.18191489
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17893559
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.17060576
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17059362
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16130701
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15779766
80RACK7_27058665_Chip-Seq_MCF-7_Human1.15344738
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15149809
82TTF2_22483619_ChIP-Seq_HELA_Human1.13527124
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13430271
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13085973
85* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12595739
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12416268
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.12382775
88VDR_23849224_ChIP-Seq_CD4+_Human1.11774926
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11166172
90* ATF3_27146783_Chip-Seq_COLON_Human1.10178583
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09567134
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.09046742
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.08186777
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06620812
95KDM5A_27292631_Chip-Seq_BREAST_Human1.05763882
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05586531
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04935262
98VDR_21846776_ChIP-Seq_THP-1_Human1.04794629
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04517625
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04085479
101CIITA_25753668_ChIP-Seq_RAJI_Human1.02885877
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02313547
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01540775
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01466930
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01291147
106CHD1_26751641_Chip-Seq_LNCaP_Human0.97174649
107* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96227707
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95755672
109PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95718869
110ELK1_19687146_ChIP-ChIP_HELA_Human0.95704083
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.94957245
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93823943
113DCP1A_22483619_ChIP-Seq_HELA_Human0.92944331
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92719099
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.91803952
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.91575805
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91562917
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91127438
119GABP_19822575_ChIP-Seq_HepG2_Human0.90451201
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.90144800
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87903376
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87319753
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87171720
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87154358
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86854292
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86572481
127ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86252341
128E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86150547
129TFEB_21752829_ChIP-Seq_HELA_Human0.84421836
130ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81815796
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81495479
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81447230
133NANOG_16518401_ChIP-PET_MESCs_Mouse0.81366593
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80608669
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79688992
136TP53_22127205_ChIP-Seq_IMR90_Human0.78730196
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78138994
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78083400
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.77808680
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77777876
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77072002
142GATA6_25053715_ChIP-Seq_YYC3_Human0.76823444
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76590819
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76590819
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75730478
146LXR_22292898_ChIP-Seq_THP-1_Human0.75723746
147NCOR1_26117541_ChIP-Seq_K562_Human0.75650973
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75540134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.85500130
2MP0004957_abnormal_blastocyst_morpholog3.45298195
3MP0006292_abnormal_olfactory_placode3.38482461
4MP0003111_abnormal_nucleus_morphology3.21190433
5MP0010094_abnormal_chromosome_stability2.98741669
6MP0002877_abnormal_melanocyte_morpholog2.92421654
7MP0003077_abnormal_cell_cycle2.87815872
8MP0004264_abnormal_extraembryonic_tissu2.84544117
9MP0003890_abnormal_embryonic-extraembry2.79746823
10MP0003693_abnormal_embryo_hatching2.78150171
11MP0002254_reproductive_system_inflammat2.54121429
12MP0003121_genomic_imprinting2.44888142
13MP0000537_abnormal_urethra_morphology2.32165326
14MP0010352_gastrointestinal_tract_polyps2.32020670
15MP0005499_abnormal_olfactory_system2.30638926
16MP0005394_taste/olfaction_phenotype2.30638926
17MP0005075_abnormal_melanosome_morpholog2.29495669
18MP0005257_abnormal_intraocular_pressure2.26317088
19MP0003011_delayed_dark_adaptation2.21536799
20MP0010030_abnormal_orbit_morphology2.19744850
21MP0003123_paternal_imprinting2.14473819
22MP0003705_abnormal_hypodermis_morpholog2.07447447
23MP0001672_abnormal_embryogenesis/_devel2.03865296
24MP0005380_embryogenesis_phenotype2.03865296
25MP0008932_abnormal_embryonic_tissue1.93988581
26MP0000350_abnormal_cell_proliferation1.93027464
27MP0002088_abnormal_embryonic_growth/wei1.82964219
28MP0003984_embryonic_growth_retardation1.82877256
29MP0003122_maternal_imprinting1.79907622
30MP0008007_abnormal_cellular_replicative1.77374627
31MP0008058_abnormal_DNA_repair1.74162827
32MP0002396_abnormal_hematopoietic_system1.73214464
33MP0001293_anophthalmia1.71190160
34MP0003938_abnormal_ear_development1.63962443
35MP0002085_abnormal_embryonic_tissue1.61745817
36MP0004272_abnormal_basement_membrane1.61111588
37MP0009053_abnormal_anal_canal1.60663358
38MP0001730_embryonic_growth_arrest1.58860995
39MP0004185_abnormal_adipocyte_glucose1.56703892
40MP0002086_abnormal_extraembryonic_tissu1.53082840
41MP0008438_abnormal_cutaneous_collagen1.48695308
42MP0002653_abnormal_ependyma_morphology1.48486594
43MP0004858_abnormal_nervous_system1.46756533
44MP0002084_abnormal_developmental_patter1.44938900
45MP0004233_abnormal_muscle_weight1.43079416
46MP0002332_abnormal_exercise_endurance1.41573987
47MP0000490_abnormal_crypts_of1.39775316
48MP0010234_abnormal_vibrissa_follicle1.39587491
49MP0005171_absent_coat_pigmentation1.36803160
50MP0002277_abnormal_respiratory_mucosa1.35938814
51MP0004197_abnormal_fetal_growth/weight/1.35538891
52MP0002092_abnormal_eye_morphology1.35459408
53MP0001697_abnormal_embryo_size1.33944008
54MP0003941_abnormal_skin_development1.30717247
55MP0003787_abnormal_imprinting1.28161816
56MP0000678_abnormal_parathyroid_gland1.27340640
57MP0008789_abnormal_olfactory_epithelium1.25813442
58MP0002932_abnormal_joint_morphology1.23635324
59MP0000049_abnormal_middle_ear1.23554621
60MP0001849_ear_inflammation1.22126047
61MP0003786_premature_aging1.21170161
62MP0000313_abnormal_cell_death1.20588300
63MP0000733_abnormal_muscle_development1.19933277
64MP0003937_abnormal_limbs/digits/tail_de1.19680543
65MP0003942_abnormal_urinary_system1.19561805
66MP0002080_prenatal_lethality1.18273354
67MP0000566_synostosis1.18251208
68MP0003385_abnormal_body_wall1.17602611
69MP0009697_abnormal_copulation1.17045967
70MP0001661_extended_life_span1.16776546
71MP0000432_abnormal_head_morphology1.16773952
72MP0000428_abnormal_craniofacial_morphol1.14361918
73MP0000762_abnormal_tongue_morphology1.14346929
74MP0000534_abnormal_ureter_morphology1.14117779
75MP0010307_abnormal_tumor_latency1.12363901
76MP0002060_abnormal_skin_morphology1.12062460
77MP0003755_abnormal_palate_morphology1.11697556
78MP0000003_abnormal_adipose_tissue1.10077364
79MP0003315_abnormal_perineum_morphology1.09778478
80MP0002233_abnormal_nose_morphology1.06463091
81MP0004133_heterotaxia1.04786833
82MP0003935_abnormal_craniofacial_develop1.04364175
83MP0009672_abnormal_birth_weight1.03330472
84MP0002127_abnormal_cardiovascular_syste1.02929563
85MP0001348_abnormal_lacrimal_gland1.02453534
86MP0006035_abnormal_mitochondrial_morpho1.02063607
87MP0002114_abnormal_axial_skeleton1.01188090
88MP0001346_abnormal_lacrimal_gland0.98279587
89MP0003115_abnormal_respiratory_system0.97426660
90MP0003119_abnormal_digestive_system0.97165595
91MP0000383_abnormal_hair_follicle0.95497196
92MP0005501_abnormal_skin_physiology0.95080763
93MP0005409_darkened_coat_color0.94114902
94MP0005408_hypopigmentation0.92187719
95MP0009250_abnormal_appendicular_skeleto0.89822687
96MP0005197_abnormal_uvea_morphology0.89657750
97MP0009703_decreased_birth_body0.89412099
98MP0005023_abnormal_wound_healing0.88443155
99MP0000467_abnormal_esophagus_morphology0.88271270
100MP0004808_abnormal_hematopoietic_stem0.88096454
101MP0002019_abnormal_tumor_incidence0.87989316
102MP0000579_abnormal_nail_morphology0.87365756
103MP0002925_abnormal_cardiovascular_devel0.87063644
104MP0001286_abnormal_eye_development0.86200879
105MP0003136_yellow_coat_color0.85311181
106MP0002111_abnormal_tail_morphology0.85239558
107MP0004381_abnormal_hair_follicle0.84757379
108MP0002249_abnormal_larynx_morphology0.83425879
109MP0002938_white_spotting0.82627414
110MP0005508_abnormal_skeleton_morphology0.81595809
111MP0000358_abnormal_cell_content/0.79595899
112MP0003861_abnormal_nervous_system0.79418360
113MP0002116_abnormal_craniofacial_bone0.78952085
114MP0008770_decreased_survivor_rate0.77833490
115MP0003718_maternal_effect0.77503388
116MP0005391_vision/eye_phenotype0.77069932
117MP0003566_abnormal_cell_adhesion0.75984622
118MP0002160_abnormal_reproductive_system0.75864320
119MP0002697_abnormal_eye_size0.75390467
120MP0003448_altered_tumor_morphology0.74862210
121MP0006082_CNS_inflammation0.74787790
122MP0003943_abnormal_hepatobiliary_system0.74751351
123MP0005384_cellular_phenotype0.74517309
124MP0001340_abnormal_eyelid_morphology0.74273163
125MP0002751_abnormal_autonomic_nervous0.74066783
126MP0005076_abnormal_cell_differentiation0.73977793
127MP0001299_abnormal_eye_distance/0.73054155
128MP0003453_abnormal_keratinocyte_physiol0.72977639
129MP0002098_abnormal_vibrissa_morphology0.72560597
130MP0005248_abnormal_Harderian_gland0.72529344
131MP0002089_abnormal_postnatal_growth/wei0.72363990
132MP0002075_abnormal_coat/hair_pigmentati0.71408717
133MP0000858_altered_metastatic_potential0.70631389
134MP0003283_abnormal_digestive_organ0.69923556
135MP0003183_abnormal_peptide_metabolism0.68785133
136MP0002132_abnormal_respiratory_system0.68073207
137MP0005623_abnormal_meninges_morphology0.66763439
138MP0003950_abnormal_plasma_membrane0.65948389
139MP0005621_abnormal_cell_physiology0.65817754

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.38495877
2Bilateral microphthalmos (HP:0007633)5.36817340
3Chromsome breakage (HP:0040012)4.97600849
4Hypochromic microcytic anemia (HP:0004840)4.38250163
5Rib fusion (HP:0000902)4.11927269
6Hepatoblastoma (HP:0002884)3.90998589
7Ependymoma (HP:0002888)3.86572852
8Nephroblastoma (Wilms tumor) (HP:0002667)3.85963538
9Embryonal renal neoplasm (HP:0011794)3.60990846
10Meckel diverticulum (HP:0002245)3.49370276
11Multiple enchondromatosis (HP:0005701)3.43545681
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.33672406
13Abnormality of the ileum (HP:0001549)3.30571032
14Impulsivity (HP:0100710)3.23417781
15Rhabdomyosarcoma (HP:0002859)3.23323444
16Neoplasm of striated muscle (HP:0009728)3.19970356
17Abnormal lung lobation (HP:0002101)3.19247457
18Fused cervical vertebrae (HP:0002949)2.97645496
19Hyperacusis (HP:0010780)2.97139810
20Premature rupture of membranes (HP:0001788)2.92809488
21Aplasia/hypoplasia of the humerus (HP:0006507)2.88484061
22Ulnar bowing (HP:0003031)2.84207260
23Small intestinal stenosis (HP:0012848)2.84155604
24Duodenal stenosis (HP:0100867)2.84155604
25Abnormality of the astrocytes (HP:0100707)2.83087008
26Astrocytoma (HP:0009592)2.83087008
27Rectal fistula (HP:0100590)2.81095826
28Rectovaginal fistula (HP:0000143)2.81095826
29Short humerus (HP:0005792)2.78931506
30Abnormality of the preputium (HP:0100587)2.72835991
31Abnormality of chromosome stability (HP:0003220)2.71838542
32Deviation of the thumb (HP:0009603)2.69247073
33Intestinal fistula (HP:0100819)2.63368699
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.60894555
35Hypoplasia of the fovea (HP:0007750)2.60894555
36Supernumerary spleens (HP:0009799)2.60162124
37Trismus (HP:0000211)2.56922847
38Abnormality of the lower motor neuron (HP:0002366)2.55834696
39Proximal placement of thumb (HP:0009623)2.53975139
40Reticulocytopenia (HP:0001896)2.46583109
41Abnormality of chromosome segregation (HP:0002916)2.41033765
42Large earlobe (HP:0009748)2.38882137
43Partial duplication of thumb phalanx (HP:0009944)2.37521290
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.36973204
45Selective tooth agenesis (HP:0001592)2.36655410
46Medulloblastoma (HP:0002885)2.36582830
47Abnormality of the distal phalanges of the toes (HP:0010182)2.35385845
48Preauricular skin tag (HP:0000384)2.33095077
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.32841840
50Glioma (HP:0009733)2.32225017
51Abnormality of the salivary glands (HP:0010286)2.31156139
52Abnormality of the duodenum (HP:0002246)2.30941899
53Myelodysplasia (HP:0002863)2.30788357
54Sloping forehead (HP:0000340)2.30684304
55Shawl scrotum (HP:0000049)2.28590916
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28434735
57Abnormality of the phalanges of the hallux (HP:0010057)2.27827589
58Short nail (HP:0001799)2.26258608
59Vaginal fistula (HP:0004320)2.24935035
60Abnormality of the proximal phalanges of the hand (HP:0009834)2.24164089
61Abnormality of the calcaneus (HP:0008364)2.22096607
62Duplication of thumb phalanx (HP:0009942)2.21591327
63Volvulus (HP:0002580)2.21449299
64Absent radius (HP:0003974)2.21346065
65Bifid tongue (HP:0010297)2.19720548
66Abnormality of the umbilical cord (HP:0010881)2.16850866
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15926159
68Absent epiphyses (HP:0010577)2.15926159
69Abnormality of the labia minora (HP:0012880)2.15462603
70Atresia of the external auditory canal (HP:0000413)2.15245702
71Broad face (HP:0000283)2.14905843
72Renal duplication (HP:0000075)2.14484158
73Short thumb (HP:0009778)2.11805650
74Partial duplication of the phalanx of hand (HP:0009999)2.11680698
75Skin tags (HP:0010609)2.10593182
76Testicular atrophy (HP:0000029)2.09168468
77Abnormality of cochlea (HP:0000375)2.09014544
78Ectopic kidney (HP:0000086)2.08921665
79Abnormal number of incisors (HP:0011064)2.08750102
80Aplasia involving forearm bones (HP:0009822)2.08581928
81Absent forearm bone (HP:0003953)2.08581928
82Birth length less than 3rd percentile (HP:0003561)2.07398748
83Broad distal phalanx of finger (HP:0009836)2.05924852
84Increased nuchal translucency (HP:0010880)2.05725804
85High anterior hairline (HP:0009890)2.04640743
86Periauricular skin pits (HP:0100277)2.03935704
87Preauricular pit (HP:0004467)2.03935704
88Bone marrow hypocellularity (HP:0005528)2.02960231
89Triphalangeal thumb (HP:0001199)2.00492685
90Protrusio acetabuli (HP:0003179)2.00388224
91Supernumerary ribs (HP:0005815)2.00134110
92Abnormality of the fetal cardiovascular system (HP:0010948)1.98692983
93Abnormal umbilical cord blood vessels (HP:0011403)1.98692983
94Single umbilical artery (HP:0001195)1.98692983
95Upper limb muscle weakness (HP:0003484)1.98246363
96Breast hypoplasia (HP:0003187)1.98102184
97Missing ribs (HP:0000921)1.97814839
98Tracheoesophageal fistula (HP:0002575)1.97497872
9911 pairs of ribs (HP:0000878)1.96097551
100Duplicated collecting system (HP:0000081)1.95714217
101Pendular nystagmus (HP:0012043)1.95496504
102Short 5th finger (HP:0009237)1.95346119
103Supernumerary bones of the axial skeleton (HP:0009144)1.94153014
104Anomalous pulmonary venous return (HP:0010772)1.93711034
105Hypochromic anemia (HP:0001931)1.93511773
106Embryonal neoplasm (HP:0002898)1.92321580
107Abnormality of DNA repair (HP:0003254)1.91854661
108Glossoptosis (HP:0000162)1.91829031
109Hypopigmentation of the fundus (HP:0007894)1.90236857
110High pitched voice (HP:0001620)1.89754440
111Insomnia (HP:0100785)1.89225882
112Flat acetabular roof (HP:0003180)1.89192514
113Abnormality of the carotid arteries (HP:0005344)1.87104959
114Patellar aplasia (HP:0006443)1.86594041
115Overlapping toe (HP:0001845)1.85613867
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85567158
117Aplasia/Hypoplasia of the macula (HP:0008059)1.85528814
118Distal lower limb amyotrophy (HP:0008944)1.85247015
119Shallow orbits (HP:0000586)1.84918730
120Clubbing of toes (HP:0100760)1.84874735
121Premature ovarian failure (HP:0008209)1.83676784
122Ankyloglossia (HP:0010296)1.83453138
123Entropion (HP:0000621)1.82423145
124Abnormality of the fovea (HP:0000493)1.82241007
125Ureteral duplication (HP:0000073)1.82113481
126Squamous cell carcinoma (HP:0002860)1.81444312
127Vertebral fusion (HP:0002948)1.81073476
128Flared metaphyses (HP:0003015)1.81053011
129Facial cleft (HP:0002006)1.80663120
130Prominent occiput (HP:0000269)1.78707378
131Nasolacrimal duct obstruction (HP:0000579)1.78399163
132Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78358714
133Choanal atresia (HP:0000453)1.78264808
134Absent thumb (HP:0009777)1.77429708
135Cortical dysplasia (HP:0002539)1.77237098
136Neoplasm of the oral cavity (HP:0100649)1.76866144
137Heterotopia (HP:0002282)1.76781630
138Ankle contracture (HP:0006466)1.75676060
139Deep philtrum (HP:0002002)1.74732245
140Horseshoe kidney (HP:0000085)1.74718589
141Abnormality of oral frenula (HP:0000190)1.73949374
142Natal tooth (HP:0000695)1.73615797
143Amyotrophic lateral sclerosis (HP:0007354)1.72845605
144Limited elbow extension (HP:0001377)1.72823543
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.72714885
146Osteolytic defects of the hand bones (HP:0009699)1.72714885
147Abnormality of the renal collecting system (HP:0004742)1.72062676
148Sensory axonal neuropathy (HP:0003390)1.71310281
149Arteriovenous malformation (HP:0100026)1.70689928
150Fragile skin (HP:0001030)1.70588831
151Aplasia/Hypoplasia of the patella (HP:0006498)1.70260541
152Disproportionate tall stature (HP:0001519)1.68330612
153Abnormal foot bone ossification (HP:0010675)1.68193993
154Cafe-au-lait spot (HP:0000957)1.67701883
155Poikiloderma (HP:0001029)1.65613580
156Urethral obstruction (HP:0000796)1.63671539
157Dislocated radial head (HP:0003083)1.63386037
158Asymmetry of the thorax (HP:0001555)1.62554510
159Patellar dislocation (HP:0002999)1.60085687
160Small epiphyses (HP:0010585)1.58820078
161Short 1st metacarpal (HP:0010034)1.58584464
162Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58584464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.84249345
2TTK3.85819716
3GRK53.36831605
4MST1R3.35790791
5GRK62.95396536
6CDC72.86655508
7SMG12.80849528
8TRIB32.79450582
9BUB12.57998916
10STK102.49537580
11EPHA22.48755341
12ERN12.42090109
13NEK22.41251334
14WEE12.37253427
15CSF1R2.30322684
16GRK12.22446771
17ADRBK22.21215938
18CDK72.11248646
19MET2.08430254
20PLK12.07465985
21PBK2.00356152
22CHEK21.95796085
23IRAK31.87535542
24NME21.80022999
25VRK21.68154917
26TYRO31.64109426
27TGFBR21.61582693
28MATK1.60676347
29MAPK71.58438511
30MOS1.56108245
31PAK41.51614275
32GRK71.48031838
33AURKB1.39461887
34SRPK11.34958790
35CHEK11.30339723
36PLK41.28975410
37SIK11.24970213
38PKN21.23599866
39MAP3K101.23242527
40WNK11.22281770
41EIF2AK21.18676395
42SCYL21.15805297
43RPS6KB21.12170609
44PDGFRA1.11289918
45ATR1.08589159
46STK41.07680835
47NEK11.05229133
48AURKA1.04755472
49CDK41.03804701
50BRSK21.00137395
51AKT30.98107412
52TAF10.97742267
53ERBB40.97343817
54CAMK40.94823902
55PRKG20.94034711
56ZAK0.92924182
57BRD40.90241571
58ATM0.90064727
59STK30.88547148
60BRAF0.85651703
61TLK10.83285602
62CDK20.82364576
63LMTK20.80062986
64CDK90.78448673
65AKT20.78260041
66MAP3K80.77670803
67LATS10.77162984
68MTOR0.73464512
69FLT30.68973272
70MARK20.68903144
71MKNK10.68462973
72BRSK10.68228931
73PLK30.67142801
74ALK0.66891427
75VRK10.65681529
76LATS20.65425162
77MELK0.65317658
78CDK10.63670216
79PRKCI0.62604294
80HIPK20.60931792
81CAMK1D0.60347086
82PAK10.59807649
83DYRK30.59537057
84CAMK1G0.58425958
85STK38L0.57827772
86ADRBK10.56916103
87MKNK20.53801216
88PNCK0.51992482
89EIF2AK10.51770581
90PTK60.49648827
91CSK0.49007507
92TTN0.47237333
93MAPK110.46345192
94CDK150.44772895
95CLK10.43888850
96CDK180.43331917
97CDK11A0.43244637
98ILK0.42673270
99PIM10.41528604
100CDK80.41027270
101FGFR30.40323021
102PRKD30.39531504
103EPHB20.39311046
104EIF2AK30.38576425
105TESK20.37772857
106NEK90.37323510
107ACVR1B0.37242971
108TSSK60.36645901
109MAPK140.35060260
110CSNK1E0.34972216
111IKBKB0.34633627
112CHUK0.33622477
113ERBB20.32465030
114PRKDC0.31903117
115MAPK10.30769384
116PASK0.30701131
117RPS6KA40.29394904
118NTRK10.29183880
119BMX0.29175835
120GSK3B0.28801987
121DDR20.28460263
122AKT10.27570283
123CDK140.26723166
124MAP3K60.25365960
125CDK60.24991922
126FGFR10.24825238
127EEF2K0.24543618
128ICK0.24164064
129YES10.23754638
130PTK20.23562062
131PAK20.23434587
132CCNB10.23311933
133DMPK0.22572766
134MAPK100.21016093
135CSNK2A10.20768273
136FGFR40.20596519
137CSNK1D0.20342949
138MAPKAPK20.18837356

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94156997
2DNA replication_Homo sapiens_hsa030303.76171467
3Vitamin B6 metabolism_Homo sapiens_hsa007503.56005869
4Mismatch repair_Homo sapiens_hsa034303.26747204
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.08560403
6Fanconi anemia pathway_Homo sapiens_hsa034602.97402412
7Homologous recombination_Homo sapiens_hsa034402.84879741
8Cell cycle_Homo sapiens_hsa041102.83421398
9RNA transport_Homo sapiens_hsa030132.69305557
10Base excision repair_Homo sapiens_hsa034102.39609616
11Spliceosome_Homo sapiens_hsa030402.30260340
12One carbon pool by folate_Homo sapiens_hsa006702.19603910
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06838129
14Nucleotide excision repair_Homo sapiens_hsa034201.99648193
15Ribosome_Homo sapiens_hsa030101.93340523
16RNA polymerase_Homo sapiens_hsa030201.90372522
17mRNA surveillance pathway_Homo sapiens_hsa030151.88881091
18p53 signaling pathway_Homo sapiens_hsa041151.79041467
19RNA degradation_Homo sapiens_hsa030181.74728211
20Biosynthesis of amino acids_Homo sapiens_hsa012301.74562110
21Fructose and mannose metabolism_Homo sapiens_hsa000511.70682821
22Non-homologous end-joining_Homo sapiens_hsa034501.65614805
23Arachidonic acid metabolism_Homo sapiens_hsa005901.50839957
24Pyrimidine metabolism_Homo sapiens_hsa002401.39672363
25Basal transcription factors_Homo sapiens_hsa030221.36818851
26MicroRNAs in cancer_Homo sapiens_hsa052061.31808803
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25217585
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22838614
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22747487
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17585244
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13930761
32Galactose metabolism_Homo sapiens_hsa000521.13902068
33N-Glycan biosynthesis_Homo sapiens_hsa005101.13619503
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11236285
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.11143633
36Sulfur relay system_Homo sapiens_hsa041221.11120025
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09674401
38Systemic lupus erythematosus_Homo sapiens_hsa053221.09443783
39Linoleic acid metabolism_Homo sapiens_hsa005911.04611111
40Basal cell carcinoma_Homo sapiens_hsa052171.03202596
41Herpes simplex infection_Homo sapiens_hsa051681.03180651
42Viral carcinogenesis_Homo sapiens_hsa052030.99017747
43Selenocompound metabolism_Homo sapiens_hsa004500.96825993
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.95992773
45mTOR signaling pathway_Homo sapiens_hsa041500.94443090
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93775362
47Carbon metabolism_Homo sapiens_hsa012000.92921577
48Small cell lung cancer_Homo sapiens_hsa052220.91016273
49Thyroid cancer_Homo sapiens_hsa052160.89461198
50Proteasome_Homo sapiens_hsa030500.84789261
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82006514
52Notch signaling pathway_Homo sapiens_hsa043300.81919062
53Hedgehog signaling pathway_Homo sapiens_hsa043400.80243246
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79727372
55Hippo signaling pathway_Homo sapiens_hsa043900.79152494
56HTLV-I infection_Homo sapiens_hsa051660.77619986
57Pathways in cancer_Homo sapiens_hsa052000.76932685
58Apoptosis_Homo sapiens_hsa042100.74875445
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73340150
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.70782525
61Pyruvate metabolism_Homo sapiens_hsa006200.70735657
62Oocyte meiosis_Homo sapiens_hsa041140.69512531
63Epstein-Barr virus infection_Homo sapiens_hsa051690.69072780
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68345298
65Glioma_Homo sapiens_hsa052140.67198952
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66368817
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66297113
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62875853
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60062402
70Other glycan degradation_Homo sapiens_hsa005110.58869850
71* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57978228
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57893658
73Adherens junction_Homo sapiens_hsa045200.57882704
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56967967
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56935026
76Bladder cancer_Homo sapiens_hsa052190.56689642
77Purine metabolism_Homo sapiens_hsa002300.54995544
78Endometrial cancer_Homo sapiens_hsa052130.53153421
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.52355398
80Ether lipid metabolism_Homo sapiens_hsa005650.51517983
81Inositol phosphate metabolism_Homo sapiens_hsa005620.50649311
82TGF-beta signaling pathway_Homo sapiens_hsa043500.50110711
83Colorectal cancer_Homo sapiens_hsa052100.49394782
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48494631
85Acute myeloid leukemia_Homo sapiens_hsa052210.48201258
86Proteoglycans in cancer_Homo sapiens_hsa052050.47735409
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.46086475
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45559852
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45113722
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44453811
91Ovarian steroidogenesis_Homo sapiens_hsa049130.44323467
92AMPK signaling pathway_Homo sapiens_hsa041520.43693888
93Pancreatic cancer_Homo sapiens_hsa052120.43258991
94ErbB signaling pathway_Homo sapiens_hsa040120.42983004
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.42534208
96Melanogenesis_Homo sapiens_hsa049160.42288191
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41912537
98Non-small cell lung cancer_Homo sapiens_hsa052230.41004392
99Influenza A_Homo sapiens_hsa051640.40954188
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40803398
101Tight junction_Homo sapiens_hsa045300.39837643
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39345951
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38924130
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38539918
105Pentose phosphate pathway_Homo sapiens_hsa000300.38483014
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38480610
107Hematopoietic cell lineage_Homo sapiens_hsa046400.38207940
108Wnt signaling pathway_Homo sapiens_hsa043100.38135091
109Insulin signaling pathway_Homo sapiens_hsa049100.37449133
110Lysine degradation_Homo sapiens_hsa003100.36665796
111ECM-receptor interaction_Homo sapiens_hsa045120.36367671
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.36182164
113Renal cell carcinoma_Homo sapiens_hsa052110.35227208
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34584531
115Rap1 signaling pathway_Homo sapiens_hsa040150.33999990
116Prostate cancer_Homo sapiens_hsa052150.33923913
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33428197
118Choline metabolism in cancer_Homo sapiens_hsa052310.33178644
119Melanoma_Homo sapiens_hsa052180.32587870
120Glutathione metabolism_Homo sapiens_hsa004800.31479292
121Steroid biosynthesis_Homo sapiens_hsa001000.31073858
122Folate biosynthesis_Homo sapiens_hsa007900.30718537
123Chronic myeloid leukemia_Homo sapiens_hsa052200.30596596
124Legionellosis_Homo sapiens_hsa051340.29683136
125Alcoholism_Homo sapiens_hsa050340.29279504
126Hepatitis B_Homo sapiens_hsa051610.28221322
127Antigen processing and presentation_Homo sapiens_hsa046120.27999998
128Renin-angiotensin system_Homo sapiens_hsa046140.27771662
129Measles_Homo sapiens_hsa051620.27539743
130Focal adhesion_Homo sapiens_hsa045100.25738088
131Viral myocarditis_Homo sapiens_hsa054160.25316800
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.25244002

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