IQSEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.20914141
2locomotory exploration behavior (GO:0035641)4.95646228
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.95402470
4negative regulation of cell killing (GO:0031342)4.95402470
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95268681
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.69807735
7neuronal action potential propagation (GO:0019227)4.45511954
8vocalization behavior (GO:0071625)4.36264768
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34634924
10positive regulation of gamma-delta T cell activation (GO:0046645)4.25866915
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24060588
12synaptic vesicle exocytosis (GO:0016079)4.18641631
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.07413858
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06667342
15sodium ion export (GO:0071436)4.04638080
16regulation of synaptic vesicle exocytosis (GO:2000300)4.04146326
17regulation of glutamate receptor signaling pathway (GO:1900449)4.00345903
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96685210
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.96685210
20modulation by symbiont of host immune response (GO:0052553)3.96685210
21positive regulation by symbiont of host defense response (GO:0052509)3.96685210
22modulation by symbiont of host defense response (GO:0052031)3.96685210
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96685210
24glutamate secretion (GO:0014047)3.96490821
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96067330
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.91743560
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89811560
28gamma-aminobutyric acid transport (GO:0015812)3.88605851
29cellular potassium ion homeostasis (GO:0030007)3.86081475
30glycine transport (GO:0015816)3.78105614
31L-amino acid import (GO:0043092)3.75248172
32macrophage activation involved in immune response (GO:0002281)3.70461218
33neurotransmitter secretion (GO:0007269)3.69861514
34negative regulation of erythrocyte differentiation (GO:0045647)3.67762246
35regulation of synapse structural plasticity (GO:0051823)3.66414101
36regulation of synaptic vesicle transport (GO:1902803)3.63814676
37protein localization to synapse (GO:0035418)3.62711972
38detection of other organism (GO:0098543)3.58780607
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55209238
40regulation of neuronal synaptic plasticity (GO:0048168)3.53075692
41cell communication by electrical coupling (GO:0010644)3.52398734
42regulation of B cell receptor signaling pathway (GO:0050855)3.51120835
43antigen processing and presentation of endogenous antigen (GO:0019883)3.49586147
44exploration behavior (GO:0035640)3.49246075
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45920329
46glutamate receptor signaling pathway (GO:0007215)3.44103690
47dendritic spine morphogenesis (GO:0060997)3.42684572
48long-term memory (GO:0007616)3.40945099
49potassium ion import (GO:0010107)3.40819590
50neurotransmitter-gated ion channel clustering (GO:0072578)3.40573172
51detection of bacterium (GO:0016045)3.40563610
52positive regulation of Rap GTPase activity (GO:0032854)3.39361268
53neuromuscular process controlling posture (GO:0050884)3.38006059
54cellular extravasation (GO:0045123)3.36928125
55synaptic transmission, glutamatergic (GO:0035249)3.32534771
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.29401629
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28616296
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26648670
59detection of molecule of bacterial origin (GO:0032490)3.26188494
60regulation of gamma-delta T cell activation (GO:0046643)3.25891964
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25049013
62activation of protein kinase A activity (GO:0034199)3.24461031
63cerebellar Purkinje cell differentiation (GO:0021702)3.21885244
64leukocyte aggregation (GO:0070486)3.20839629
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19290908
66positive regulation of membrane potential (GO:0045838)3.18795203
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16967946
68detection of external biotic stimulus (GO:0098581)3.15308442
69proline transport (GO:0015824)3.12122727
70layer formation in cerebral cortex (GO:0021819)3.11660560
71response to peptidoglycan (GO:0032494)3.11470571
72neurotransmitter transport (GO:0006836)3.09392925
73regulation of postsynaptic membrane potential (GO:0060078)3.08008750
74neuron-neuron synaptic transmission (GO:0007270)3.07840998
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06749026
76membrane depolarization during action potential (GO:0086010)3.05531524
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05293608
78neuron cell-cell adhesion (GO:0007158)3.05259312
79negative regulation of leukocyte mediated immunity (GO:0002704)3.04037770
80response to muramyl dipeptide (GO:0032495)3.00445680
81amino acid import (GO:0043090)2.99944104
82auditory behavior (GO:0031223)2.99922894
83neuromuscular process controlling balance (GO:0050885)2.99399664
84signal complex assembly (GO:0007172)2.99337543
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96165644
86postsynaptic membrane organization (GO:0001941)2.94620034
87regulation of Rap GTPase activity (GO:0032317)2.91808384
88positive thymic T cell selection (GO:0045059)2.91104344
89neutrophil activation involved in immune response (GO:0002283)2.90667578
90potassium ion homeostasis (GO:0055075)2.88090108
91adult walking behavior (GO:0007628)2.87760927
92regulation of gamma-delta T cell differentiation (GO:0045586)2.87445017
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87290161
94regulation of voltage-gated calcium channel activity (GO:1901385)2.86835270
95positive regulation of cellular amide metabolic process (GO:0034250)2.86124607
96regulation of T-helper 2 cell differentiation (GO:0045628)2.85150293
97response to auditory stimulus (GO:0010996)2.84185889
98microglial cell activation (GO:0001774)2.83616459
99regulation of neurotransmitter levels (GO:0001505)2.83492028
100response to interleukin-15 (GO:0070672)2.83472685
101membrane depolarization (GO:0051899)2.82069211
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81918681
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80183527
104negative regulation of interleukin-12 production (GO:0032695)2.77857993
105regulation of regulated secretory pathway (GO:1903305)2.77605421
106negative regulation of T cell mediated immunity (GO:0002710)2.77472101
107regulation of synaptic plasticity (GO:0048167)2.77381835
108detection of biotic stimulus (GO:0009595)2.77216088
109macrophage activation (GO:0042116)2.77120813
110leukocyte migration involved in inflammatory response (GO:0002523)2.76474237
111membrane hyperpolarization (GO:0060081)2.76145259
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75982155
113B cell receptor signaling pathway (GO:0050853)2.75559794
114regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74886785
115cellular sodium ion homeostasis (GO:0006883)2.72691896
116prepulse inhibition (GO:0060134)2.72620462
117regulation of neurotransmitter secretion (GO:0046928)2.71675486
118regulation of dendritic spine morphogenesis (GO:0061001)2.71621529
119regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71506163
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.70637973
121negative regulation of toll-like receptor signaling pathway (GO:0034122)2.69727326
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68800316
123negative thymic T cell selection (GO:0045060)2.66935580
124regulation of mast cell degranulation (GO:0043304)2.66671710
125dendrite morphogenesis (GO:0048813)2.66289312
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66174967
127cell communication involved in cardiac conduction (GO:0086065)2.66128533
128regulation of beta-amyloid formation (GO:1902003)2.65568031
129regulation of synaptic transmission, glutamatergic (GO:0051966)2.65264149
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64878656
131germinal center formation (GO:0002467)2.64583083
132regulation of leukocyte degranulation (GO:0043300)2.64111808
133regulation of ARF GTPase activity (GO:0032312)2.64053578
134synaptic vesicle endocytosis (GO:0048488)2.62989692
135positive regulation of dendritic spine development (GO:0060999)2.62525020
136* regulation of ARF protein signal transduction (GO:0032012)2.62161751
137positive regulation of neurotransmitter transport (GO:0051590)2.61951255
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61826513
139long-term synaptic potentiation (GO:0060291)2.60715484
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60510333
141response to host immune response (GO:0052572)2.60297180
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60297180
143presynaptic membrane assembly (GO:0097105)2.59922395
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59224730
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.58832935
146regulation of amyloid precursor protein catabolic process (GO:1902991)2.58679634
147transmission of nerve impulse (GO:0019226)2.58506197
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.56398945
149negative T cell selection (GO:0043383)2.56176827
150cerebellar granule cell differentiation (GO:0021707)2.55820696
151regulation of neurotransmitter transport (GO:0051588)2.55750079
152activated T cell proliferation (GO:0050798)2.55413897
153positive T cell selection (GO:0043368)2.55057748
154myeloid cell activation involved in immune response (GO:0002275)2.53904222
155regulation of dendritic spine development (GO:0060998)2.52268435
156negative regulation of type 2 immune response (GO:0002829)2.52055720
157regulation of cellular amide metabolic process (GO:0034248)2.51913595
158regulation of macrophage cytokine production (GO:0010935)2.51543278
159positive regulation of neurotransmitter secretion (GO:0001956)2.51460402
160neuromuscular process (GO:0050905)2.51139773
161positive regulation of mast cell activation (GO:0033005)2.51064030
162regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50902462
163regulation of calcium ion transmembrane transport (GO:1903169)2.48501759
164regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48501759
165cerebellar Purkinje cell layer development (GO:0021680)2.47634283
166thymic T cell selection (GO:0045061)2.47237642
167T cell selection (GO:0045058)2.46965406
168response to host (GO:0075136)2.46484637
169response to host defenses (GO:0052200)2.46484637
170response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46484637
171positive regulation of macrophage cytokine production (GO:0060907)2.45821325
172regulation of interferon-beta biosynthetic process (GO:0045357)2.41139779
173actin filament polymerization (GO:0030041)2.38811312
174regulation of mast cell activation involved in immune response (GO:0033006)2.38492421
175neutrophil activation (GO:0042119)2.37797072
176cellular response to interleukin-15 (GO:0071350)2.37152845
177respiratory burst (GO:0045730)2.37052252
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36108472
179positive regulation of synapse maturation (GO:0090129)2.33022630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36637828
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74945031
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73579923
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70240585
5DROSHA_22980978_ChIP-Seq_HELA_Human2.60487317
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60374493
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60374493
8GBX2_23144817_ChIP-Seq_PC3_Human2.54974687
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.45339958
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38244731
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38067148
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.31654393
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30883468
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28651817
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25065474
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24700006
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19037255
18VDR_21846776_ChIP-Seq_THP-1_Human2.13896257
19TCF7_22412390_ChIP-Seq_EML_Mouse2.13366469
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.11262367
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.10797915
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09826880
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08103514
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02672610
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.01998655
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99259902
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96706767
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.95258995
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.95068201
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92815063
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91413036
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90006736
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88627760
34VDR_24763502_ChIP-Seq_THP-1_Human1.82633764
35* RUNX_20019798_ChIP-Seq_JUKART_Human1.81726333
36* SPI1_23127762_ChIP-Seq_K562_Human1.81537649
37AR_21572438_ChIP-Seq_LNCaP_Human1.78125429
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.75060055
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72112073
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70845960
41* MYC_22102868_ChIP-Seq_BL_Human1.69705755
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.64975893
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62824316
44* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60276050
45MAF_26560356_Chip-Seq_TH1_Human1.60172778
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58637216
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57820031
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57047469
49SCL_19346495_ChIP-Seq_HPC-7_Human1.52168672
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.51947911
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47106937
52* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44204385
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.44156606
54* KDM2B_26808549_Chip-Seq_K562_Human1.44123074
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44114822
56* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43222085
57* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42716661
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.39284786
59UTX_26944678_Chip-Seq_JUKART_Human1.37091230
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36021193
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35258318
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35139994
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31705703
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30569179
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29992787
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.29423490
67* GATA1_19941826_ChIP-Seq_K562_Human1.29006575
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.28841242
69MAF_26560356_Chip-Seq_TH2_Human1.26911804
70SMC4_20622854_ChIP-Seq_HELA_Human1.24729955
71SMAD4_21799915_ChIP-Seq_A2780_Human1.21180077
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21138710
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20508200
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19919223
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19548235
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.19511379
77* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18873234
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15475998
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15470401
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15232694
81VDR_24787735_ChIP-Seq_THP-1_Human1.14542241
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12381134
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12125864
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11844330
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11768332
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10192755
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10076325
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09927019
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09726669
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09205813
91* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09061287
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08978098
93* AR_19668381_ChIP-Seq_PC3_Human1.08757633
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07457525
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.04421568
96P68_20966046_ChIP-Seq_HELA_Human1.04391813
97RACK7_27058665_Chip-Seq_MCF-7_Human1.04148600
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02639566
99* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02405636
100* OCT4_19829295_ChIP-Seq_ESCs_Human1.02276270
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02100635
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01849028
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.01555131
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01491908
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.00947256
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00479289
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.00010828
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99984919
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98953199
110RING1B_27294783_Chip-Seq_NPCs_Mouse0.98224120
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97823003
112CREB1_26743006_Chip-Seq_LNCaP_Human0.97645204
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97588294
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96672727
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96656959
116* STAT3_23295773_ChIP-Seq_U87_Human0.95925367
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95477700
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95371997
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94764613
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.94302492
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93286856
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.93138304
123* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92907572
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92861746
125RXR_22108803_ChIP-Seq_LS180_Human0.92769270
126AR_25329375_ChIP-Seq_VCAP_Human0.92489521
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92359745
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92069920
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.91719643
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91500701
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91226834
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.91129520
133MYB_26560356_Chip-Seq_TH2_Human0.90534510
134TP53_16413492_ChIP-PET_HCT116_Human0.90037609
135CTCF_27219007_Chip-Seq_Bcells_Human0.89791095
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88907984
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87567010
138KDM2B_26808549_Chip-Seq_DND41_Human0.86492648
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86382343
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86074656
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85894164
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85260284
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84705291
144* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84426902
145* TCF4_23295773_ChIP-Seq_U87_Human0.84409704
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83952255
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83782494
148LXR_22292898_ChIP-Seq_THP-1_Human0.83230816
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.81692790
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81292492
151* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79567668
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78657212
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.78376628
154* KLF4_19829295_ChIP-Seq_ESCs_Human0.77908189
155* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77210208
156TAF15_26573619_Chip-Seq_HEK293_Human0.76698336
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.75025816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01072290
2MP0003880_abnormal_central_pattern4.20447079
3* MP0003635_abnormal_synaptic_transmissio3.73568260
4MP0009046_muscle_twitch3.40985661
5MP0003436_decreased_susceptibility_to3.32363389
6MP0003724_increased_susceptibility_to3.27643555
7MP0004270_analgesia3.14087988
8MP0009745_abnormal_behavioral_response3.08749112
9MP0002064_seizures3.04066318
10MP0002063_abnormal_learning/memory/cond2.71035429
11MP0005423_abnormal_somatic_nervous2.64581704
12MP0002272_abnormal_nervous_system2.54218200
13MP0001486_abnormal_startle_reflex2.53806265
14MP0008569_lethality_at_weaning2.49777478
15MP0001968_abnormal_touch/_nociception2.38010875
16MP0002572_abnormal_emotion/affect_behav2.30800645
17MP0001501_abnormal_sleep_pattern2.19815116
18MP0002419_abnormal_innate_immunity2.15240939
19MP0000751_myopathy2.13560925
20MP0008260_abnormal_autophagy2.12712691
21MP0002734_abnormal_mechanical_nocicepti2.06655087
22MP0002822_catalepsy2.05404547
23MP0001835_abnormal_antigen_presentation2.03387377
24MP0003191_abnormal_cellular_cholesterol1.99919778
25MP0001790_abnormal_immune_system1.96787845
26MP0005387_immune_system_phenotype1.96787845
27MP0005000_abnormal_immune_tolerance1.96494049
28MP0005025_abnormal_response_to1.93697539
29MP0002067_abnormal_sensory_capabilities1.93447390
30MP0001800_abnormal_humoral_immune1.91973434
31MP0003646_muscle_fatigue1.88252282
32MP0000685_abnormal_immune_system1.86385042
33MP0005671_abnormal_response_to1.83714039
34MP0002909_abnormal_adrenal_gland1.75169975
35MP0003300_gastrointestinal_ulcer1.72856586
36MP0004510_myositis1.72614818
37MP0004858_abnormal_nervous_system1.69346294
38MP0002723_abnormal_immune_serum1.68831748
39MP0006082_CNS_inflammation1.66701024
40MP0002420_abnormal_adaptive_immunity1.66655285
41MP0004885_abnormal_endolymph1.65037422
42MP0001970_abnormal_pain_threshold1.63418664
43MP0001819_abnormal_immune_cell1.63407880
44MP0004145_abnormal_muscle_electrophysio1.62766071
45MP0002736_abnormal_nociception_after1.62335228
46MP0003690_abnormal_glial_cell1.62122066
47MP0003329_amyloid_beta_deposits1.61827823
48MP0001440_abnormal_grooming_behavior1.61390960
49MP0009780_abnormal_chondrocyte_physiolo1.59915429
50MP0003633_abnormal_nervous_system1.59447044
51MP0002837_dystrophic_cardiac_calcinosis1.59401243
52MP0001533_abnormal_skeleton_physiology1.55274873
53MP0003879_abnormal_hair_cell1.53830406
54MP0002452_abnormal_antigen_presenting1.53805544
55MP0002733_abnormal_thermal_nociception1.52606711
56MP0002735_abnormal_chemical_nociception1.51565334
57MP0003763_abnormal_thymus_physiology1.51275442
58MP0000920_abnormal_myelination1.48088387
59MP0005451_abnormal_body_composition1.43289732
60MP0005386_behavior/neurological_phenoty1.43009234
61MP0004924_abnormal_behavior1.43009234
62MP0004130_abnormal_muscle_cell1.42224783
63MP0009278_abnormal_bone_marrow1.40206352
64MP0004811_abnormal_neuron_physiology1.40044500
65MP0004142_abnormal_muscle_tone1.39160578
66MP0009785_altered_susceptibility_to1.38115573
67MP0002557_abnormal_social/conspecific_i1.37767103
68MP0003183_abnormal_peptide_metabolism1.36618358
69MP0002184_abnormal_innervation1.33371225
70MP0000955_abnormal_spinal_cord1.32081688
71MP0005058_abnormal_lysosome_morphology1.31860661
72MP0005464_abnormal_platelet_physiology1.30920080
73MP0000778_abnormal_nervous_system1.30846456
74MP0002066_abnormal_motor_capabilities/c1.29863693
75MP0008961_abnormal_basal_metabolism1.26234856
76MP0003828_pulmonary_edema1.25891939
77MP0004947_skin_inflammation1.25029955
78MP0005167_abnormal_blood-brain_barrier1.24331896
79MP0004215_abnormal_myocardial_fiber1.21880472
80MP0000716_abnormal_immune_system1.21762017
81MP0003631_nervous_system_phenotype1.21656656
82MP0001502_abnormal_circadian_rhythm1.21569245
83MP0002882_abnormal_neuron_morphology1.21397479
84MP0002398_abnormal_bone_marrow1.20788580
85MP0000569_abnormal_digit_pigmentation1.20478466
86MP0002405_respiratory_system_inflammati1.19528898
87MP0001851_eye_inflammation1.19364407
88MP0003075_altered_response_to1.17606993
89MP0005166_decreased_susceptibility_to1.16089986
90MP0005623_abnormal_meninges_morphology1.14958385
91MP0005409_darkened_coat_color1.14899475
92MP0005646_abnormal_pituitary_gland1.11084230
93MP0003137_abnormal_impulse_conducting1.10980842
94MP0004484_altered_response_of1.10891394
95MP0008874_decreased_physiological_sensi1.10201232
96MP0002229_neurodegeneration1.09953618
97MP0002998_abnormal_bone_remodeling1.09591118
98MP0003866_abnormal_defecation1.07471159
99MP0002148_abnormal_hypersensitivity_rea1.07180204
100MP0003303_peritoneal_inflammation1.04671071
101MP0003634_abnormal_glial_cell1.04584424
102MP0005551_abnormal_eye_electrophysiolog1.04540293
103MP0000749_muscle_degeneration1.04210180
104MP0005535_abnormal_body_temperature1.03904718
105MP0005310_abnormal_salivary_gland1.03890978
106MP0004085_abnormal_heartbeat1.00193431
107MP0005670_abnormal_white_adipose0.99627038
108MP0004883_abnormal_blood_vessel0.99548643
109MP0002132_abnormal_respiratory_system0.99323821
110MP0004036_abnormal_muscle_relaxation0.98920280
111MP0005645_abnormal_hypothalamus_physiol0.98779959
112MP0001845_abnormal_inflammatory_respons0.96558868
113MP0001986_abnormal_taste_sensitivity0.94202957
114MP0004381_abnormal_hair_follicle0.94046258
115MP0003122_maternal_imprinting0.93497481
116MP0001177_atelectasis0.92856309
117MP0000013_abnormal_adipose_tissue0.91936857
118MP0003045_fibrosis0.91045677
119MP0010155_abnormal_intestine_physiology0.89827327
120MP0000703_abnormal_thymus_morphology0.87321990
121MP0002722_abnormal_immune_system0.85990239
122MP0006276_abnormal_autonomic_nervous0.84745904
123MP0002429_abnormal_blood_cell0.83922573
124MP0002152_abnormal_brain_morphology0.83443468
125MP0000689_abnormal_spleen_morphology0.83258036
126MP0004084_abnormal_cardiac_muscle0.82639870
127MP0003787_abnormal_imprinting0.82159372
128MP0000747_muscle_weakness0.82071888
129MP0003656_abnormal_erythrocyte_physiolo0.80862190
130MP0002090_abnormal_vision0.80815021
131MP0004742_abnormal_vestibular_system0.80533570
132MP0003091_abnormal_cell_migration0.80408389
133MP0003705_abnormal_hypodermis_morpholog0.80279437
134MP0003172_abnormal_lysosome_physiology0.79351588
135MP0000604_amyloidosis0.79224847
136MP0001545_abnormal_hematopoietic_system0.78939632
137MP0005397_hematopoietic_system_phenotyp0.78939632
138MP0005620_abnormal_muscle_contractility0.78327738
139MP0005388_respiratory_system_phenotype0.78190322
140MP0002133_abnormal_respiratory_system0.78190322
141MP0009333_abnormal_splenocyte_physiolog0.78177289
142MP0008469_abnormal_protein_level0.77304916
143MP0004087_abnormal_muscle_fiber0.75634005
144MP0003632_abnormal_nervous_system0.75560862
145MP0001905_abnormal_dopamine_level0.75129621
146MP0002069_abnormal_eating/drinking_beha0.74836556
147MP0005076_abnormal_cell_differentiation0.71939904
148MP0002972_abnormal_cardiac_muscle0.71429007
149MP0008872_abnormal_physiological_respon0.69865215
150MP0001984_abnormal_olfaction0.68627505
151MP0005375_adipose_tissue_phenotype0.67354710
152MP0000759_abnormal_skeletal_muscle0.65957600
153MP0001188_hyperpigmentation0.64224921
154MP0005666_abnormal_adipose_tissue0.63300618
155MP0002752_abnormal_somatic_nervous0.61505546
156MP0001963_abnormal_hearing_physiology0.60834787
157MP0008775_abnormal_heart_ventricle0.60793316
158MP0002106_abnormal_muscle_physiology0.59494185
159MP0005330_cardiomyopathy0.59115344

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.68849316
2Myokymia (HP:0002411)5.94309431
3Focal seizures (HP:0007359)4.96431575
4Eczematoid dermatitis (HP:0000976)4.94375310
5Action tremor (HP:0002345)4.67198570
6Visual hallucinations (HP:0002367)4.30351148
7Progressive cerebellar ataxia (HP:0002073)4.27955153
8Febrile seizures (HP:0002373)4.19142696
9Supranuclear gaze palsy (HP:0000605)3.89630007
10Recurrent gram-negative bacterial infections (HP:0005420)3.85954949
11Recurrent bacterial skin infections (HP:0005406)3.83997381
12Hemiplegia (HP:0002301)3.83435264
13Recurrent abscess formation (HP:0002722)3.77390384
14Myositis (HP:0100614)3.75132885
15Abnormality of macrophages (HP:0004311)3.64346022
16Orchitis (HP:0100796)3.60593366
17Gaze-evoked nystagmus (HP:0000640)3.58654748
18Epileptic encephalopathy (HP:0200134)3.53703555
19Dysdiadochokinesis (HP:0002075)3.49906448
20Atonic seizures (HP:0010819)3.49483979
21Optic neuritis (HP:0100653)3.47519310
22Retrobulbar optic neuritis (HP:0100654)3.47519310
23Genetic anticipation (HP:0003743)3.38191500
24Dysmetria (HP:0001310)3.33025298
25Depression (HP:0000716)3.26921172
26Broad-based gait (HP:0002136)3.26529166
27Generalized tonic-clonic seizures (HP:0002069)3.26392609
28Dysmetric saccades (HP:0000641)3.15389356
29Absence seizures (HP:0002121)3.11738026
30Ventricular fibrillation (HP:0001663)3.10033916
31Postural instability (HP:0002172)3.07116140
32Ankle clonus (HP:0011448)3.07000793
33Abnormal eating behavior (HP:0100738)3.02571807
34Scanning speech (HP:0002168)2.95702399
35Dialeptic seizures (HP:0011146)2.94851384
36Gastrointestinal infarctions (HP:0005244)2.94041476
37Urinary bladder sphincter dysfunction (HP:0002839)2.86117126
38Bundle branch block (HP:0011710)2.85015429
39Anxiety (HP:0000739)2.83417365
40Spontaneous hematomas (HP:0007420)2.77378251
41Impaired social interactions (HP:0000735)2.76078995
42Abnormal social behavior (HP:0012433)2.76078995
43Sudden death (HP:0001699)2.75516656
44Hemiparesis (HP:0001269)2.75355240
45Poor eye contact (HP:0000817)2.74630873
46Truncal ataxia (HP:0002078)2.73951864
47Meningitis (HP:0001287)2.73198792
48Cellulitis (HP:0100658)2.72367627
49Intention tremor (HP:0002080)2.72188981
50Mediastinal lymphadenopathy (HP:0100721)2.71375211
51Abnormality of binocular vision (HP:0011514)2.68880757
52Diplopia (HP:0000651)2.68880757
53Prolonged QT interval (HP:0001657)2.65081099
54Stomatitis (HP:0010280)2.63939758
55Annular pancreas (HP:0001734)2.63470504
56Mutism (HP:0002300)2.62073432
57Obstructive lung disease (HP:0006536)2.59245615
58Chronic obstructive pulmonary disease (HP:0006510)2.59245615
59Gingivitis (HP:0000230)2.58607151
60Elevated erythrocyte sedimentation rate (HP:0003565)2.56364703
61Amyloidosis (HP:0011034)2.55357361
62Increased IgE level (HP:0003212)2.55238111
63Recurrent fungal infections (HP:0002841)2.53321669
64Keratoconjunctivitis sicca (HP:0001097)2.51598649
65Torticollis (HP:0000473)2.50571709
66Progressive inability to walk (HP:0002505)2.49689590
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.47311093
68Atrial fibrillation (HP:0005110)2.47252381
69Recurrent skin infections (HP:0001581)2.46308908
70Obstructive sleep apnea (HP:0002870)2.45209598
71Abnormal EKG (HP:0003115)2.43143856
72Vasculitis (HP:0002633)2.39500912
73Primary atrial arrhythmia (HP:0001692)2.37482918
74Prolonged bleeding time (HP:0003010)2.36236657
75Episodic fever (HP:0001954)2.35320158
76Abnormality of saccadic eye movements (HP:0000570)2.34134990
77Impaired vibration sensation in the lower limbs (HP:0002166)2.33001129
78Urinary urgency (HP:0000012)2.31801443
79Impaired smooth pursuit (HP:0007772)2.28433877
80Lower limb amyotrophy (HP:0007210)2.28313804
81Status epilepticus (HP:0002133)2.25440599
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.24125572
83Onion bulb formation (HP:0003383)2.23966401
84Papilledema (HP:0001085)2.22774206
85Neurofibrillary tangles (HP:0002185)2.22719199
86Syncope (HP:0001279)2.22125692
87Keratoconjunctivitis (HP:0001096)2.20615245
88Exercise-induced myalgia (HP:0003738)2.19924600
89Stereotypic behavior (HP:0000733)2.19036302
90Difficulty running (HP:0009046)2.18159937
91Pulmonary embolism (HP:0002204)2.17686288
92Supraventricular tachycardia (HP:0004755)2.17308814
93Hypercortisolism (HP:0001578)2.16798139
94Focal dystonia (HP:0004373)2.15699167
95Hypochromic microcytic anemia (HP:0004840)2.13259932
96Encephalitis (HP:0002383)2.13006362
97Supraventricular arrhythmia (HP:0005115)2.12593349
98Neuronal loss in central nervous system (HP:0002529)2.11004370
99Peripheral hypomyelination (HP:0007182)2.08874083
100Amblyopia (HP:0000646)2.08645835
101Spastic gait (HP:0002064)2.08094665
102Agitation (HP:0000713)2.07681388
103Gingival bleeding (HP:0000225)2.07200921
104Urticaria (HP:0001025)2.06588637
105Segmental peripheral demyelination/remyelination (HP:0003481)2.05388582
106Chest pain (HP:0100749)2.05309227
107Peritonitis (HP:0002586)2.03284704
108Hypochromic anemia (HP:0001931)2.02399442
109Abnormality of ocular smooth pursuit (HP:0000617)2.02383609
110Heart block (HP:0012722)2.02154948
111Increased variability in muscle fiber diameter (HP:0003557)2.01828198
112Rapidly progressive (HP:0003678)2.01772051
113Lower limb muscle weakness (HP:0007340)2.01336867
114Bradykinesia (HP:0002067)2.00756076
115Chronic mucocutaneous candidiasis (HP:0002728)2.00342101
116Recurrent cutaneous fungal infections (HP:0011370)2.00342101
117Excessive salivation (HP:0003781)1.98396311
118Drooling (HP:0002307)1.98396311
119Megalencephaly (HP:0001355)1.96309557
120Colitis (HP:0002583)1.96173701
121Nonprogressive disorder (HP:0003680)1.95053766
122Slow saccadic eye movements (HP:0000514)1.94655510
123Epistaxis (HP:0000421)1.93792600
124Insomnia (HP:0100785)1.93642661
125Gastrointestinal inflammation (HP:0004386)1.93584676
126Pulmonary infiltrates (HP:0002113)1.93141105
127Polycythemia (HP:0001901)1.92334528
128Inflammation of the large intestine (HP:0002037)1.91274316
129Craniofacial dystonia (HP:0012179)1.90759267
130Broad metatarsal (HP:0001783)1.90524411
131Hemoptysis (HP:0002105)1.88354931
132Increased cerebral lipofuscin (HP:0011813)1.88269560
133Impaired vibratory sensation (HP:0002495)1.87775204
134Vertigo (HP:0002321)1.87729337
135Memory impairment (HP:0002354)1.87033786
136Abnormality of the fingertips (HP:0001211)1.86894244
137Bradycardia (HP:0001662)1.86882011
138Pointed chin (HP:0000307)1.86709588
139Psychosis (HP:0000709)1.85412126
140Abnormal atrioventricular conduction (HP:0005150)1.84786075
141Purpura (HP:0000979)1.84094390
142Lower limb asymmetry (HP:0100559)1.83351621
143Rigidity (HP:0002063)1.83334617
144Myotonia (HP:0002486)1.83286713
145Arterial thrombosis (HP:0004420)1.82066805
146Ventricular arrhythmia (HP:0004308)1.79933085
147Deep venous thrombosis (HP:0002625)1.79893873
148Systemic lupus erythematosus (HP:0002725)1.79537552
149Gait ataxia (HP:0002066)1.78831355
150Cerebral inclusion bodies (HP:0100314)1.77036330
151Aplasia involving bones of the extremities (HP:0009825)1.76718901
152Aplasia involving bones of the upper limbs (HP:0009823)1.76718901
153Aplasia of the phalanges of the hand (HP:0009802)1.76718901
154Gastrointestinal stroma tumor (HP:0100723)1.76309182
155Calf muscle hypertrophy (HP:0008981)1.76286818
156Osteomyelitis (HP:0002754)1.76169266
157Macroorchidism (HP:0000053)1.75934795
158Cerebral aneurysm (HP:0004944)1.75862268
159Incomplete penetrance (HP:0003829)1.75706653
160Dysostosis multiplex (HP:0000943)1.75037614
161Apathy (HP:0000741)1.74379698
162Muscle fiber splitting (HP:0003555)1.73765673
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73142011
164Decreased motor nerve conduction velocity (HP:0003431)1.73034501
165Atrioventricular block (HP:0001678)1.72461324
166Spinal canal stenosis (HP:0003416)1.72341359
167Horizontal nystagmus (HP:0000666)1.71396731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.38315883
2EPHA42.89034724
3MAP3K92.71892217
4DAPK22.23943572
5ERN12.23064842
6STK382.21236468
7MAP3K42.20353554
8MAP4K12.19814419
9PRKD32.16683563
10PAK62.15923514
11CAMKK12.12470569
12MAP2K72.02342254
13BLK1.98466647
14MINK11.96089393
15TNIK1.87938849
16RIPK41.86919351
17NTRK21.85306057
18MAP2K31.81538530
19FES1.78900558
20MUSK1.74304567
21TYK21.69541709
22PRPF4B1.65570007
23CAMK1G1.64045322
24MARK11.62883065
25MAP2K41.60072276
26IRAK41.59981741
27PHKG11.54093612
28PHKG21.54093612
29PINK11.53847414
30CSK1.53159494
31SIK21.52077710
32LMTK21.49643841
33CAMKK21.48211910
34NTRK11.47640165
35CAMK11.46642487
36MAP3K111.45685465
37WNK11.44113386
38EPHB11.43326565
39STK111.38758511
40CDK51.37585269
41CASK1.32541006
42KSR21.30940470
43PRKCH1.30788137
44ZAP701.29002150
45CDK191.28642217
46UHMK11.27486672
47TNK21.25803805
48SGK4941.22801314
49SGK2231.22801314
50RIPK11.20867151
51GRK61.18763869
52PRKD21.11702532
53SGK31.11681354
54SYK1.11250027
55FGFR41.10247834
56JAK21.05948716
57CAMK1D1.02864086
58MARK21.02190728
59GRK51.01891893
60MAP3K121.01716077
61MAP3K130.99489817
62SGK20.99271706
63MAP3K70.98870825
64MAP3K30.97839987
65ICK0.97146964
66TAOK10.96622023
67MAPK130.96620524
68DMPK0.94638513
69TRIB30.93718233
70FGR0.93600994
71IRAK20.92313871
72CDC42BPA0.92151986
73PDK10.91658158
74BTK0.88934159
75FGFR30.88151269
76PDPK10.88067176
77CAMK2A0.87828476
78CDK120.86717644
79CAMK40.83742745
80BMX0.82887851
81SGK10.82221492
82PRKCG0.79316802
83IKBKE0.77627055
84ARAF0.76634055
85MAPK120.74733311
86MAPK70.74248747
87JAK30.73130624
88RET0.72204329
89OXSR10.71795202
90PRKD10.71343483
91MAP3K140.71001463
92PKN10.69060652
93CAMK2B0.69047490
94MAP3K10.68234964
95DAPK10.67999113
96TYRO30.67958552
97ALK0.67284943
98TAOK20.66134266
99SMG10.65493585
100TBK10.65463164
101SIK30.65452658
102PTK2B0.65173871
103CAMK2D0.65112295
104DYRK1B0.64875812
105BMPR20.64010421
106PAK30.61151775
107HIPK20.60357638
108LYN0.60143909
109ITK0.59825414
110JAK10.59433698
111LCK0.58258365
112FYN0.57549623
113ROCK10.56752615
114ROCK20.56155403
115CAMK2G0.54678889
116RPS6KA30.54082584
117RAF10.53215305
118PLK20.52059382
119DAPK30.51369794
120KSR10.49884369
121MAPK100.49342680
122PTK60.49311275
123MAP3K20.48847149
124SIK10.47897391
125MARK30.47888350
126RPS6KA20.47468409
127CDK150.47364599
128TTN0.46572311
129MAPKAPK50.46395086
130NEK60.46332019
131YES10.46244952
132STK390.46198324
133PRKG20.44564714
134PRKCE0.44484625
135PRKCZ0.43391809
136CDK180.43279340
137PNCK0.43118401
138LATS20.42942768
139DYRK1A0.42352115
140HCK0.41244519
141WNK40.40641344
142CDK11A0.40631397

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.77286566
2Synaptic vesicle cycle_Homo sapiens_hsa047212.60942222
3Olfactory transduction_Homo sapiens_hsa047402.33400540
4Circadian entrainment_Homo sapiens_hsa047132.32185919
5GABAergic synapse_Homo sapiens_hsa047272.28858407
6Glutamatergic synapse_Homo sapiens_hsa047242.27936706
7Morphine addiction_Homo sapiens_hsa050322.15336965
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13296395
9Salivary secretion_Homo sapiens_hsa049702.04842174
10Long-term potentiation_Homo sapiens_hsa047202.04827038
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00479062
12Gastric acid secretion_Homo sapiens_hsa049711.87849970
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77527572
14Nitrogen metabolism_Homo sapiens_hsa009101.74654410
15Cholinergic synapse_Homo sapiens_hsa047251.70076743
16Leishmaniasis_Homo sapiens_hsa051401.69357790
17Amphetamine addiction_Homo sapiens_hsa050311.67960902
18Insulin secretion_Homo sapiens_hsa049111.67106364
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66568923
20Staphylococcus aureus infection_Homo sapiens_hsa051501.62242364
21Dopaminergic synapse_Homo sapiens_hsa047281.56476961
22Renin secretion_Homo sapiens_hsa049241.51911050
23Long-term depression_Homo sapiens_hsa047301.46802532
24Calcium signaling pathway_Homo sapiens_hsa040201.46427249
25Oxytocin signaling pathway_Homo sapiens_hsa049211.46074144
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42068970
27Tuberculosis_Homo sapiens_hsa051521.40268261
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38771838
29Taste transduction_Homo sapiens_hsa047421.36878737
30Acute myeloid leukemia_Homo sapiens_hsa052211.34792419
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34418538
32GnRH signaling pathway_Homo sapiens_hsa049121.31712741
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31320163
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31112660
35cAMP signaling pathway_Homo sapiens_hsa040241.31069175
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29109536
37Cocaine addiction_Homo sapiens_hsa050301.25127761
38T cell receptor signaling pathway_Homo sapiens_hsa046601.25054235
39Type II diabetes mellitus_Homo sapiens_hsa049301.24346700
40Dilated cardiomyopathy_Homo sapiens_hsa054141.20207554
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19855607
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19354236
43Serotonergic synapse_Homo sapiens_hsa047261.17160162
44Gap junction_Homo sapiens_hsa045401.11583374
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09666109
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08340783
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.05209187
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03997110
49Cardiac muscle contraction_Homo sapiens_hsa042601.00505067
50Phototransduction_Homo sapiens_hsa047440.98648419
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98011164
52Endometrial cancer_Homo sapiens_hsa052130.96059795
53Glioma_Homo sapiens_hsa052140.95674954
54Malaria_Homo sapiens_hsa051440.95672513
55Estrogen signaling pathway_Homo sapiens_hsa049150.92806324
56Melanogenesis_Homo sapiens_hsa049160.92478655
57Collecting duct acid secretion_Homo sapiens_hsa049660.91068812
58Toxoplasmosis_Homo sapiens_hsa051450.90565737
59Prolactin signaling pathway_Homo sapiens_hsa049170.90236133
60Graft-versus-host disease_Homo sapiens_hsa053320.90086316
61Chronic myeloid leukemia_Homo sapiens_hsa052200.90059639
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.87700898
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.86920749
64Allograft rejection_Homo sapiens_hsa053300.86392314
65ErbB signaling pathway_Homo sapiens_hsa040120.86083140
66Axon guidance_Homo sapiens_hsa043600.85975856
67Notch signaling pathway_Homo sapiens_hsa043300.82648548
68Pancreatic secretion_Homo sapiens_hsa049720.82042624
69Other glycan degradation_Homo sapiens_hsa005110.80894342
70Autoimmune thyroid disease_Homo sapiens_hsa053200.80072941
71Prion diseases_Homo sapiens_hsa050200.79023849
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78578158
73Phagosome_Homo sapiens_hsa041450.78516642
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78506615
75Pancreatic cancer_Homo sapiens_hsa052120.76694874
76TNF signaling pathway_Homo sapiens_hsa046680.76682475
77Influenza A_Homo sapiens_hsa051640.76009336
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74435320
79Measles_Homo sapiens_hsa051620.73841489
80African trypanosomiasis_Homo sapiens_hsa051430.72658958
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72147573
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.71444537
83Hepatitis B_Homo sapiens_hsa051610.71281301
84MAPK signaling pathway_Homo sapiens_hsa040100.71250916
85Primary immunodeficiency_Homo sapiens_hsa053400.71122732
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71065526
87Choline metabolism in cancer_Homo sapiens_hsa052310.70960114
88Hepatitis C_Homo sapiens_hsa051600.70124557
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69601510
90HIF-1 signaling pathway_Homo sapiens_hsa040660.67971848
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.67900283
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67709397
93Type I diabetes mellitus_Homo sapiens_hsa049400.66704976
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.66579921
95Pertussis_Homo sapiens_hsa051330.66340540
96Thyroid hormone synthesis_Homo sapiens_hsa049180.66266545
97FoxO signaling pathway_Homo sapiens_hsa040680.66042055
98Viral myocarditis_Homo sapiens_hsa054160.65921568
99Inositol phosphate metabolism_Homo sapiens_hsa005620.65646711
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65478447
101Bile secretion_Homo sapiens_hsa049760.62908560
102Rap1 signaling pathway_Homo sapiens_hsa040150.62822431
103Chemokine signaling pathway_Homo sapiens_hsa040620.59268215
104Fatty acid biosynthesis_Homo sapiens_hsa000610.58896200
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.58722132
106VEGF signaling pathway_Homo sapiens_hsa043700.57294588
107Ras signaling pathway_Homo sapiens_hsa040140.56429965
108Ovarian steroidogenesis_Homo sapiens_hsa049130.56257700
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56109153
110Glucagon signaling pathway_Homo sapiens_hsa049220.55962008
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55014570
112B cell receptor signaling pathway_Homo sapiens_hsa046620.54040558
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53783410
114Insulin signaling pathway_Homo sapiens_hsa049100.53682857
115* Endocytosis_Homo sapiens_hsa041440.53591876
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53590342
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52926467
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.52748265
119Platelet activation_Homo sapiens_hsa046110.52668541
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52630263
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50421602
122Non-small cell lung cancer_Homo sapiens_hsa052230.47357567
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46891458
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46199035
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45749351
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44650167
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43965423
128Renal cell carcinoma_Homo sapiens_hsa052110.43389256
129mTOR signaling pathway_Homo sapiens_hsa041500.40351938
130Circadian rhythm_Homo sapiens_hsa047100.39315297
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37586670
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.36091005
133Osteoclast differentiation_Homo sapiens_hsa043800.35913621
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35452971
135Insulin resistance_Homo sapiens_hsa049310.35105976
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34265760
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34169157

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