IQSEC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.58659027
2synaptic vesicle maturation (GO:0016188)6.32990984
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.88947445
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75639338
5locomotory exploration behavior (GO:0035641)5.64255298
6synaptic vesicle exocytosis (GO:0016079)5.63335638
7vocalization behavior (GO:0071625)5.48143974
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.38495368
9glutamate secretion (GO:0014047)5.33678002
10regulation of synaptic vesicle exocytosis (GO:2000300)5.24863023
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10537711
12cerebellar granule cell differentiation (GO:0021707)5.08694847
13protein localization to synapse (GO:0035418)5.01758502
14regulation of glutamate receptor signaling pathway (GO:1900449)4.84782536
15neurotransmitter secretion (GO:0007269)4.71217648
16regulation of synaptic vesicle transport (GO:1902803)4.70043595
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.50215939
18cellular potassium ion homeostasis (GO:0030007)4.46004519
19exploration behavior (GO:0035640)4.39079603
20regulation of neuronal synaptic plasticity (GO:0048168)4.38390073
21sodium ion export (GO:0071436)4.34354031
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.28314276
23amino acid import (GO:0043090)4.27150793
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21228328
25regulation of synapse maturation (GO:0090128)4.20016439
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19297921
27neuronal action potential propagation (GO:0019227)4.17949994
28neuron cell-cell adhesion (GO:0007158)4.14834000
29layer formation in cerebral cortex (GO:0021819)4.09500795
30neuronal ion channel clustering (GO:0045161)4.09284063
31synaptic transmission, glutamatergic (GO:0035249)4.08621072
32regulation of synapse structural plasticity (GO:0051823)4.07183407
33axon ensheathment in central nervous system (GO:0032291)4.03017122
34central nervous system myelination (GO:0022010)4.03017122
35glutamate receptor signaling pathway (GO:0007215)4.02991137
36positive regulation of dendritic spine development (GO:0060999)3.99935003
37neurotransmitter-gated ion channel clustering (GO:0072578)3.99353741
38neurotransmitter transport (GO:0006836)3.97415852
39dendritic spine morphogenesis (GO:0060997)3.96337419
40gamma-aminobutyric acid transport (GO:0015812)3.96051747
41neuron-neuron synaptic transmission (GO:0007270)3.91906758
42positive regulation of membrane potential (GO:0045838)3.91804966
43long-term memory (GO:0007616)3.91465935
44retinal cone cell development (GO:0046549)3.84692661
45synaptic vesicle endocytosis (GO:0048488)3.83506012
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82901693
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.77885391
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.77494087
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76053837
50positive regulation of synapse maturation (GO:0090129)3.75035409
51proline transport (GO:0015824)3.74421425
52regulation of postsynaptic membrane potential (GO:0060078)3.68754909
53cerebellar Purkinje cell differentiation (GO:0021702)3.67101475
54negative regulation of dendrite morphogenesis (GO:0050774)3.66333190
55glycine transport (GO:0015816)3.63723921
56neuromuscular process controlling posture (GO:0050884)3.63676956
57regulation of neurotransmitter secretion (GO:0046928)3.63074755
58cell communication by electrical coupling (GO:0010644)3.55516914
59membrane hyperpolarization (GO:0060081)3.54425293
60regulation of neurotransmitter levels (GO:0001505)3.52766693
61positive regulation of neurotransmitter transport (GO:0051590)3.48218406
62regulation of synaptic plasticity (GO:0048167)3.44430969
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.43935778
64activation of protein kinase A activity (GO:0034199)3.42865096
65neurotransmitter uptake (GO:0001504)3.42351245
66L-amino acid import (GO:0043092)3.41623372
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.39488272
68regulation of vesicle fusion (GO:0031338)3.37091227
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36208822
70long-term synaptic potentiation (GO:0060291)3.35951542
71regulation of neurotransmitter transport (GO:0051588)3.35506552
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33554011
73innervation (GO:0060384)3.32328102
74dendritic spine organization (GO:0097061)3.30828932
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.29201544
76regulation of dendritic spine development (GO:0060998)3.29031664
77neuromuscular process controlling balance (GO:0050885)3.28463263
78cell differentiation in hindbrain (GO:0021533)3.28455221
79transmission of nerve impulse (GO:0019226)3.28283485
80* regulation of ARF protein signal transduction (GO:0032012)3.27901998
81membrane depolarization during action potential (GO:0086010)3.27123193
82cytoskeletal anchoring at plasma membrane (GO:0007016)3.26431242
83neuron recognition (GO:0008038)3.26318573
84potassium ion homeostasis (GO:0055075)3.26203496
85response to pheromone (GO:0019236)3.25301988
86positive regulation of neurotransmitter secretion (GO:0001956)3.24224094
87acidic amino acid transport (GO:0015800)3.22905580
88response to histamine (GO:0034776)3.22475384
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.21668281
90regulation of dendritic spine morphogenesis (GO:0061001)3.21642398
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21103771
92vesicle docking involved in exocytosis (GO:0006904)3.20461605
93neuromuscular synaptic transmission (GO:0007274)3.16867729
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16805005
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16358772
96membrane depolarization (GO:0051899)3.14759043
97regulation of voltage-gated calcium channel activity (GO:1901385)3.13469808
98response to auditory stimulus (GO:0010996)3.13451379
99regulation of exocytosis (GO:0017157)3.12702544
100regulation of clathrin-mediated endocytosis (GO:2000369)3.12654066
101potassium ion import (GO:0010107)3.11867009
102signal release (GO:0023061)3.11709618
103negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10836459
104detection of calcium ion (GO:0005513)3.09902458
105prepulse inhibition (GO:0060134)3.09604308
106dendrite morphogenesis (GO:0048813)3.09253043
107synaptic vesicle transport (GO:0048489)3.08902332
108establishment of synaptic vesicle localization (GO:0097480)3.08902332
109postsynaptic membrane organization (GO:0001941)3.06419823
110positive regulation of synaptic transmission (GO:0050806)3.04870582
111learning (GO:0007612)3.03602195
112cellular sodium ion homeostasis (GO:0006883)3.03274283
113synaptic transmission (GO:0007268)3.03218658
114chemosensory behavior (GO:0007635)3.02880469
115social behavior (GO:0035176)3.02110267
116intraspecies interaction between organisms (GO:0051703)3.02110267
117auditory behavior (GO:0031223)3.01980739
118establishment of mitochondrion localization (GO:0051654)3.00896632
119behavioral defense response (GO:0002209)2.98960886
120behavioral fear response (GO:0001662)2.98960886
121neuromuscular process (GO:0050905)2.98663751
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97670798
123axonal fasciculation (GO:0007413)2.96062592
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.95834530
125regulation of synaptic transmission (GO:0050804)2.95691182
126regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94780085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79712968
2GBX2_23144817_ChIP-Seq_PC3_Human3.46461957
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03850857
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00481354
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97469091
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.83245652
7DROSHA_22980978_ChIP-Seq_HELA_Human2.78439167
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72060910
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72060910
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65244576
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.59407832
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55351267
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53865697
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50937547
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50280573
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48792559
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.41530612
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35339077
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.33787105
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32684351
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31230424
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22396316
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19438674
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18244695
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.16925565
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07690066
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97485554
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96817893
29AR_21572438_ChIP-Seq_LNCaP_Human1.93419757
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87577553
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87421577
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69283362
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60794094
34SMAD4_21799915_ChIP-Seq_A2780_Human1.59421699
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.55877476
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47155681
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.39772009
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39491682
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37827646
40* TET1_21490601_ChIP-Seq_MESCs_Mouse1.30003016
41AR_19668381_ChIP-Seq_PC3_Human1.29424056
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.28451200
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.27503972
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26416353
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26018012
46ZNF274_21170338_ChIP-Seq_K562_Hela1.24799609
47TAF15_26573619_Chip-Seq_HEK293_Human1.24204784
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23279481
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22831269
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22213297
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21837273
52KDM2B_26808549_Chip-Seq_K562_Human1.20921007
53P300_19829295_ChIP-Seq_ESCs_Human1.19964269
54STAT3_23295773_ChIP-Seq_U87_Human1.19963952
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19794663
56AR_25329375_ChIP-Seq_VCAP_Human1.19449903
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17839612
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17812192
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.16627270
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.16571890
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.15438876
62IGF1R_20145208_ChIP-Seq_DFB_Human1.14205056
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13868832
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13257240
65LXR_22292898_ChIP-Seq_THP-1_Human1.13160224
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12788703
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10827846
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10487368
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09692900
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06867296
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06122632
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.05888327
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05600690
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05514592
75TCF4_23295773_ChIP-Seq_U87_Human1.04880003
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03989295
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03896805
78* OCT4_19829295_ChIP-Seq_ESCs_Human1.02989059
79RNF2_27304074_Chip-Seq_NSC_Mouse1.02286803
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02249342
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01464323
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.99276138
83ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99262125
84* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98849633
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98456189
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98124081
87DPY_21335234_ChIP-Seq_ESCs_Mouse0.98107930
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.97859095
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.97805532
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97793224
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97286373
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96229740
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.96198399
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96065379
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.93509899
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93417426
97AHR_22903824_ChIP-Seq_MCF-7_Human0.92736572
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92387550
99* SMC4_20622854_ChIP-Seq_HELA_Human0.92203375
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.91752241
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91664373
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90691391
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.89934012
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89674600
105CTCF_27219007_Chip-Seq_Bcells_Human0.89468034
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88926778
107* KLF4_19829295_ChIP-Seq_ESCs_Human0.87986717
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87481760
109RUNX2_22187159_ChIP-Seq_PCA_Human0.86303334
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85038845
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85038845
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84902297
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83003717
114TP53_16413492_ChIP-PET_HCT116_Human0.82759328
115CREB1_26743006_Chip-Seq_LNCaP_Human0.82685840
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82284495
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81972167
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81899070
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81705372
120KDM2B_26808549_Chip-Seq_DND41_Human0.78708111
121P68_20966046_ChIP-Seq_HELA_Human0.78411801
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.78304346
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.77687992
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77320632
125MYC_19915707_ChIP-ChIP_AK7_Human0.76712781
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76569716
127* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75378092
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74207440
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71906705
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70483537
131* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68891370
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.67283489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.41369175
2MP0003880_abnormal_central_pattern4.77084742
3MP0003635_abnormal_synaptic_transmissio4.07386693
4MP0004270_analgesia3.51780318
5MP0005423_abnormal_somatic_nervous3.46194260
6MP0009745_abnormal_behavioral_response3.29567353
7MP0002063_abnormal_learning/memory/cond3.19805062
8MP0002064_seizures3.16801264
9MP0009046_muscle_twitch3.10904225
10MP0005551_abnormal_eye_electrophysiolog2.91364819
11MP0001968_abnormal_touch/_nociception2.83917223
12MP0001486_abnormal_startle_reflex2.71749930
13MP0002572_abnormal_emotion/affect_behav2.66480909
14MP0002272_abnormal_nervous_system2.61623723
15MP0002734_abnormal_mechanical_nocicepti2.58985595
16MP0002822_catalepsy2.42480880
17MP0001501_abnormal_sleep_pattern2.28421261
18MP0002736_abnormal_nociception_after2.00329875
19MP0008569_lethality_at_weaning1.96296723
20MP0002067_abnormal_sensory_capabilities1.94699445
21MP0001440_abnormal_grooming_behavior1.93843676
22MP0002735_abnormal_chemical_nociception1.90584286
23MP0001970_abnormal_pain_threshold1.83532309
24MP0009780_abnormal_chondrocyte_physiolo1.78472586
25MP0006072_abnormal_retinal_apoptosis1.78381844
26MP0002733_abnormal_thermal_nociception1.77825802
27MP0002909_abnormal_adrenal_gland1.74019188
28MP0004811_abnormal_neuron_physiology1.73944411
29MP0002184_abnormal_innervation1.71722234
30MP0001984_abnormal_olfaction1.67885865
31MP0002557_abnormal_social/conspecific_i1.67343202
32MP0005253_abnormal_eye_physiology1.65708697
33MP0006276_abnormal_autonomic_nervous1.64405513
34MP0004924_abnormal_behavior1.63628341
35MP0005386_behavior/neurological_phenoty1.63628341
36MP0005646_abnormal_pituitary_gland1.62736564
37MP0004858_abnormal_nervous_system1.62316693
38MP0004885_abnormal_endolymph1.61009648
39MP0002882_abnormal_neuron_morphology1.60783676
40MP0000778_abnormal_nervous_system1.59462820
41MP0001502_abnormal_circadian_rhythm1.59180522
42MP0002090_abnormal_vision1.58962122
43MP0003123_paternal_imprinting1.56775651
44MP0003329_amyloid_beta_deposits1.56372007
45MP0000955_abnormal_spinal_cord1.51969473
46MP0003879_abnormal_hair_cell1.46898139
47MP0003787_abnormal_imprinting1.46216377
48MP0002229_neurodegeneration1.45570115
49MP0005645_abnormal_hypothalamus_physiol1.39392952
50MP0002066_abnormal_motor_capabilities/c1.38115402
51MP0004142_abnormal_muscle_tone1.31773403
52MP0003633_abnormal_nervous_system1.31577846
53MP0003122_maternal_imprinting1.31070680
54MP0004147_increased_porphyrin_level1.22603901
55MP0000751_myopathy1.12986824
56MP0003011_delayed_dark_adaptation1.12726673
57MP0003631_nervous_system_phenotype1.09441160
58MP0002638_abnormal_pupillary_reflex1.09087369
59MP0002752_abnormal_somatic_nervous1.08714498
60MP0000569_abnormal_digit_pigmentation1.07643480
61MP0001905_abnormal_dopamine_level1.06611810
62MP0002152_abnormal_brain_morphology1.06289504
63MP0004233_abnormal_muscle_weight1.05320203
64MP0008872_abnormal_physiological_respon1.02735599
65MP0004145_abnormal_muscle_electrophysio1.01337001
66MP0005195_abnormal_posterior_eye0.97881801
67MP0001529_abnormal_vocalization0.97366115
68MP0001177_atelectasis0.96418249
69MP0008961_abnormal_basal_metabolism0.96361203
70MP0001986_abnormal_taste_sensitivity0.94621346
71MP0003634_abnormal_glial_cell0.93533726
72MP0010386_abnormal_urinary_bladder0.93449503
73MP0003690_abnormal_glial_cell0.92762298
74MP0002069_abnormal_eating/drinking_beha0.91492096
75MP0005394_taste/olfaction_phenotype0.90988597
76MP0005499_abnormal_olfactory_system0.90988597
77MP0001348_abnormal_lacrimal_gland0.90494690
78MP0004742_abnormal_vestibular_system0.88662444
79MP0001188_hyperpigmentation0.86621813
80MP0003075_altered_response_to0.86157378
81MP0001963_abnormal_hearing_physiology0.84672921
82MP0004085_abnormal_heartbeat0.84113321
83MP0001485_abnormal_pinna_reflex0.82368815
84MP0008877_abnormal_DNA_methylation0.79911527
85MP0004215_abnormal_myocardial_fiber0.78264377
86MP0000631_abnormal_neuroendocrine_gland0.77503943
87MP0003632_abnormal_nervous_system0.77271567
88MP0008874_decreased_physiological_sensi0.75970390
89MP0003283_abnormal_digestive_organ0.75272926
90MP0000920_abnormal_myelination0.74566355
91MP0005535_abnormal_body_temperature0.74191053
92MP0001346_abnormal_lacrimal_gland0.73204538
93MP0003137_abnormal_impulse_conducting0.73078147
94MP0004130_abnormal_muscle_cell0.72355645
95MP0000013_abnormal_adipose_tissue0.68633955
96MP0003172_abnormal_lysosome_physiology0.61296565
97MP0003121_genomic_imprinting0.60253100
98MP0001299_abnormal_eye_distance/0.60236005
99MP0002653_abnormal_ependyma_morphology0.58883170
100MP0000604_amyloidosis0.57629748
101MP0005409_darkened_coat_color0.57451989
102MP0001664_abnormal_digestion0.55705349
103MP0004043_abnormal_pH_regulation0.55483170
104MP0005167_abnormal_blood-brain_barrier0.54859513
105MP0010769_abnormal_survival0.54057196
106MP0005623_abnormal_meninges_morphology0.52721066
107MP0001943_abnormal_respiration0.52210541
108MP0010768_mortality/aging0.51886447
109MP0001324_abnormal_eye_pigmentation0.51855704
110MP0002082_postnatal_lethality0.51368238
111MP0010770_preweaning_lethality0.51368238
112MP0003956_abnormal_body_size0.51250402
113MP0003045_fibrosis0.47468455
114MP0005166_decreased_susceptibility_to0.46480740
115MP0004510_myositis0.45499127
116MP0002873_normal_phenotype0.43778395
117MP0001765_abnormal_ion_homeostasis0.43327507
118MP0005448_abnormal_energy_balance0.43058588
119MP0002169_no_abnormal_phenotype0.42247076
120MP0000026_abnormal_inner_ear0.40711846

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.81352421
2Myokymia (HP:0002411)6.61187845
3Congenital stationary night blindness (HP:0007642)5.53850781
4Focal seizures (HP:0007359)5.22846378
5Visual hallucinations (HP:0002367)5.08215039
6Epileptic encephalopathy (HP:0200134)4.82546384
7Febrile seizures (HP:0002373)4.77245432
8Progressive cerebellar ataxia (HP:0002073)4.58847192
9Atonic seizures (HP:0010819)4.01595587
10Central scotoma (HP:0000603)4.00974879
11Absence seizures (HP:0002121)3.95141713
12Dyschromatopsia (HP:0007641)3.92913436
13Action tremor (HP:0002345)3.91366908
14Abnormality of macular pigmentation (HP:0008002)3.77853995
15Obstructive sleep apnea (HP:0002870)3.77437717
16Supranuclear gaze palsy (HP:0000605)3.74476903
17Cerebral hypomyelination (HP:0006808)3.68383071
18Generalized tonic-clonic seizures (HP:0002069)3.63477958
19Dialeptic seizures (HP:0011146)3.53298871
20Tetraplegia (HP:0002445)3.52299999
21Ankle clonus (HP:0011448)3.45133992
22Dysdiadochokinesis (HP:0002075)3.37986814
23Depression (HP:0000716)3.30991268
24Bony spicule pigmentary retinopathy (HP:0007737)3.25602081
25Broad-based gait (HP:0002136)3.19866982
26Gaze-evoked nystagmus (HP:0000640)3.16880686
27Abnormal rod and cone electroretinograms (HP:0008323)3.12920060
28Urinary bladder sphincter dysfunction (HP:0002839)3.12381314
29Mutism (HP:0002300)3.12224048
30Postural instability (HP:0002172)3.11242452
31Truncal ataxia (HP:0002078)3.09717342
32Genetic anticipation (HP:0003743)3.08182870
33Scotoma (HP:0000575)3.03115823
34Delusions (HP:0000746)3.02516683
35Impaired vibration sensation in the lower limbs (HP:0002166)3.00179420
36Dysmetria (HP:0001310)3.00035437
37Poor eye contact (HP:0000817)2.98546340
38Decreased central vision (HP:0007663)2.96953711
39Akinesia (HP:0002304)2.93335627
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92983897
41Anxiety (HP:0000739)2.87133513
42Neuronal loss in central nervous system (HP:0002529)2.86907705
43Abnormal eating behavior (HP:0100738)2.84210489
44Ventricular fibrillation (HP:0001663)2.81239855
45Abnormality of the lower motor neuron (HP:0002366)2.78047996
46Abnormal social behavior (HP:0012433)2.77177332
47Impaired social interactions (HP:0000735)2.77177332
48Sleep apnea (HP:0010535)2.76890017
49Impaired smooth pursuit (HP:0007772)2.69417355
50Abnormality of the corticospinal tract (HP:0002492)2.68585952
51Scanning speech (HP:0002168)2.64418183
52Hemiplegia (HP:0002301)2.58399190
53Papilledema (HP:0001085)2.58105649
54Apathy (HP:0000741)2.55034505
55Hemiparesis (HP:0001269)2.52437921
56Rigidity (HP:0002063)2.51331779
57Urinary urgency (HP:0000012)2.51004117
58Amblyopia (HP:0000646)2.50094067
59Hyperventilation (HP:0002883)2.47913972
60Peripheral hypomyelination (HP:0007182)2.47733120
61Intention tremor (HP:0002080)2.47129078
62Spastic gait (HP:0002064)2.45381140
63Torticollis (HP:0000473)2.44342231
64Excessive salivation (HP:0003781)2.43155873
65Drooling (HP:0002307)2.43155873
66Severe visual impairment (HP:0001141)2.40965161
67Choreoathetosis (HP:0001266)2.40531070
68Bradykinesia (HP:0002067)2.40525734
69Spastic tetraparesis (HP:0001285)2.39254118
70Abnormality of ocular smooth pursuit (HP:0000617)2.39099438
71Diminished motivation (HP:0000745)2.31163091
72Progressive inability to walk (HP:0002505)2.27052452
73CNS hypomyelination (HP:0003429)2.26422163
74Dysmetric saccades (HP:0000641)2.22289570
75Focal dystonia (HP:0004373)2.21075599
76Increased circulating renin level (HP:0000848)2.20711069
77Rapidly progressive (HP:0003678)2.18617962
78Pheochromocytoma (HP:0002666)2.15817356
79Insomnia (HP:0100785)2.15215606
80Fetal akinesia sequence (HP:0001989)2.14376289
81Morphological abnormality of the pyramidal tract (HP:0002062)2.13011528
82Epileptiform EEG discharges (HP:0011182)2.12646783
83Abnormality of binocular vision (HP:0011514)2.12411805
84Diplopia (HP:0000651)2.12411805
85Stereotypic behavior (HP:0000733)2.12026442
86Absent speech (HP:0001344)2.11970746
87Lower limb asymmetry (HP:0100559)2.11655984
88Status epilepticus (HP:0002133)2.10649070
89Choroideremia (HP:0001139)2.10628476
90Lower limb muscle weakness (HP:0007340)2.06677223
91Spinal canal stenosis (HP:0003416)2.06474404
92Abnormal EKG (HP:0003115)2.06221888
93EEG with generalized epileptiform discharges (HP:0011198)2.05510276
94Impaired vibratory sensation (HP:0002495)2.04948503
95Pendular nystagmus (HP:0012043)2.02547136
96Abolished electroretinogram (ERG) (HP:0000550)2.01491874
97Megalencephaly (HP:0001355)2.01119378
98Attenuation of retinal blood vessels (HP:0007843)2.01093977
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99574020
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.99574020
101Pigmentary retinal degeneration (HP:0001146)1.97617691
102Bundle branch block (HP:0011710)1.96218294
103Neurofibrillary tangles (HP:0002185)1.96041353
104Craniofacial dystonia (HP:0012179)1.95603617
105Agitation (HP:0000713)1.94754660
106Pointed chin (HP:0000307)1.94599150
107Polyphagia (HP:0002591)1.94408550
108Generalized myoclonic seizures (HP:0002123)1.94306892
109Prolonged QT interval (HP:0001657)1.93121743
110Photophobia (HP:0000613)1.91912035
111Hypsarrhythmia (HP:0002521)1.89766743
112Clonus (HP:0002169)1.86405840
113Type II diabetes mellitus (HP:0005978)1.85324447
114Abnormality of saccadic eye movements (HP:0000570)1.83471397
115Hypoventilation (HP:0002791)1.83203235
116Annular pancreas (HP:0001734)1.83125388
117Gait imbalance (HP:0002141)1.82478503
118Limb dystonia (HP:0002451)1.82112315
119Unsteady gait (HP:0002317)1.81966296
120Cerebral inclusion bodies (HP:0100314)1.79816655
121Memory impairment (HP:0002354)1.79036325
122Gait ataxia (HP:0002066)1.78048854
123Lower limb amyotrophy (HP:0007210)1.76891648
124Neuroendocrine neoplasm (HP:0100634)1.76384905
125Incomplete penetrance (HP:0003829)1.76239377
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75860265
127Amyotrophic lateral sclerosis (HP:0007354)1.75706787
128Heart block (HP:0012722)1.72449748
129Slow progression (HP:0003677)1.71066763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.50211808
2EPHA43.85972814
3MAP3K93.82371671
4MAP3K43.09654321
5MARK12.97654725
6MINK12.79237005
7PAK62.60914421
8MAP2K72.52564305
9PRKD32.35280588
10NTRK22.34452271
11DAPK22.32527692
12CAMKK12.01092389
13STK381.94793136
14MAP2K41.88632342
15MAP3K121.87399613
16PRPF4B1.73836542
17KSR21.72374551
18NTRK11.68754776
19CDK51.60013888
20TNIK1.52783118
21SIK21.50696475
22GRK51.37727078
23RIPK41.37612472
24KSR11.37609940
25DAPK11.34036010
26UHMK11.29980511
27MAPK131.29638706
28CASK1.25940365
29PLK21.25920132
30CDK191.24339661
31FES1.23749024
32PRKCG1.23199139
33PINK11.18488940
34PNCK1.15097753
35CAMK11.13711537
36PHKG11.13605541
37PHKG21.13605541
38SGK4941.07477547
39SGK2231.07477547
40TYRO30.99438910
41STK110.98445566
42PRKCH0.98154613
43MAP3K130.97804255
44CDK180.97278353
45TNK20.96987268
46CDK150.96650380
47TAOK10.95274942
48CAMK2A0.95104300
49ARAF0.91943987
50SGK20.90831648
51ALK0.90494411
52CDK140.89749697
53MAP3K20.89366080
54CAMKK20.88880042
55DYRK1A0.88656935
56CDK11A0.84880654
57LMTK20.83722128
58SGK30.82371095
59LATS20.81920486
60PAK30.78943498
61MARK20.78413690
62NEK10.77588251
63CAMK1G0.77123701
64MAP3K110.75797880
65GRK10.73255267
66RET0.72242441
67WNK10.72109945
68SGK10.71685427
69PKN10.70706543
70MAP3K70.69114933
71CAMK2B0.67920112
72DAPK30.66452222
73RIPK10.62992367
74CDC42BPA0.62935141
75FGFR20.61998829
76RPS6KA30.60093098
77PDK10.59607579
78OXSR10.57544186
79PRKCZ0.57433712
80MAPK100.56877535
81CAMK40.56514009
82CSNK1G20.55362154
83NEK60.54833940
84CAMK2D0.54182314
85RAF10.52332885
86PDPK10.49716142
87MAP3K10.49520605
88PTK2B0.49391942
89PRKG20.47781894
90BRAF0.46939374
91TAOK20.46101975
92CAMK2G0.45549393
93BRSK10.45343644
94LIMK10.45013691
95FYN0.43909896
96PRKCE0.41672497
97PRKCB0.40727163
98MAP2K60.40044931
99NME10.40008803
100BMPR20.39807408
101SIK30.39462153
102WNK30.39390304
103TESK10.37771505
104FER0.37388075
105SCYL20.36625876
106ROCK20.34675673
107PRKCA0.33187431
108RPS6KA20.32178178
109MAPKAPK50.31148327
110MAPK120.31106430
111ROCK10.29746575
112IRAK20.28464917
113PRKG10.27828209
114MAPK80.26954116
115ERBB20.26733095
116JAK20.26662949
117PRKACA0.25106199

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.75066477
2Phototransduction_Homo sapiens_hsa047443.59897974
3Synaptic vesicle cycle_Homo sapiens_hsa047213.56027736
4GABAergic synapse_Homo sapiens_hsa047272.93677512
5Olfactory transduction_Homo sapiens_hsa047402.81955985
6Circadian entrainment_Homo sapiens_hsa047132.69242553
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64813370
8Morphine addiction_Homo sapiens_hsa050322.57523405
9Glutamatergic synapse_Homo sapiens_hsa047242.54842858
10Long-term potentiation_Homo sapiens_hsa047202.30533749
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27097929
12Amphetamine addiction_Homo sapiens_hsa050312.16053277
13Salivary secretion_Homo sapiens_hsa049702.10502772
14Dopaminergic synapse_Homo sapiens_hsa047282.07092091
15Insulin secretion_Homo sapiens_hsa049112.05445774
16Cholinergic synapse_Homo sapiens_hsa047251.94043618
17Gastric acid secretion_Homo sapiens_hsa049711.83008016
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78639577
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66448249
20Oxytocin signaling pathway_Homo sapiens_hsa049211.62789348
21Serotonergic synapse_Homo sapiens_hsa047261.58726435
22Taste transduction_Homo sapiens_hsa047421.57002384
23Renin secretion_Homo sapiens_hsa049241.53807153
24Calcium signaling pathway_Homo sapiens_hsa040201.51734377
25Cocaine addiction_Homo sapiens_hsa050301.49474564
26Vitamin B6 metabolism_Homo sapiens_hsa007501.44773124
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44309191
28Long-term depression_Homo sapiens_hsa047301.43779529
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43134056
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42580740
31Nitrogen metabolism_Homo sapiens_hsa009101.41401536
32GnRH signaling pathway_Homo sapiens_hsa049121.32950101
33cAMP signaling pathway_Homo sapiens_hsa040241.25706176
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22255421
35Collecting duct acid secretion_Homo sapiens_hsa049661.20319507
36Type II diabetes mellitus_Homo sapiens_hsa049301.19583169
37Gap junction_Homo sapiens_hsa045401.18426545
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14459800
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10373738
40Cardiac muscle contraction_Homo sapiens_hsa042601.03173533
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01577548
42Glioma_Homo sapiens_hsa052141.00061971
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98213778
44Estrogen signaling pathway_Homo sapiens_hsa049150.97058385
45Axon guidance_Homo sapiens_hsa043600.94565897
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92969132
47ErbB signaling pathway_Homo sapiens_hsa040120.91870464
48Melanogenesis_Homo sapiens_hsa049160.86390211
49Dilated cardiomyopathy_Homo sapiens_hsa054140.84750683
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.82974094
51Pancreatic secretion_Homo sapiens_hsa049720.81582168
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.80099941
53Circadian rhythm_Homo sapiens_hsa047100.77287154
54Vibrio cholerae infection_Homo sapiens_hsa051100.76224628
55Oocyte meiosis_Homo sapiens_hsa041140.74162187
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72171695
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71741172
58Dorso-ventral axis formation_Homo sapiens_hsa043200.70545939
59MAPK signaling pathway_Homo sapiens_hsa040100.69354615
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65062956
61Choline metabolism in cancer_Homo sapiens_hsa052310.64771206
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62334943
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58595346
64Inositol phosphate metabolism_Homo sapiens_hsa005620.58179388
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56656580
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56441425
67Bile secretion_Homo sapiens_hsa049760.56235348
68mTOR signaling pathway_Homo sapiens_hsa041500.55186069
69Ras signaling pathway_Homo sapiens_hsa040140.54205806
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53268558
71Glucagon signaling pathway_Homo sapiens_hsa049220.52891113
72Type I diabetes mellitus_Homo sapiens_hsa049400.51041068
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.50961733
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48023755
75Alcoholism_Homo sapiens_hsa050340.47684909
76Rap1 signaling pathway_Homo sapiens_hsa040150.47434243
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46954020
78* Endocytosis_Homo sapiens_hsa041440.46568768
79VEGF signaling pathway_Homo sapiens_hsa043700.45570694
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45384260
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45052435
82Arginine and proline metabolism_Homo sapiens_hsa003300.43654781
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43276491
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42666740
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.41589119
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40241762
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39899810
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37852990
89Wnt signaling pathway_Homo sapiens_hsa043100.36853072
90Ovarian steroidogenesis_Homo sapiens_hsa049130.36659178
91Endometrial cancer_Homo sapiens_hsa052130.35769556
92Insulin signaling pathway_Homo sapiens_hsa049100.34048732
93Renal cell carcinoma_Homo sapiens_hsa052110.33734353
94Non-small cell lung cancer_Homo sapiens_hsa052230.33080848
95Chemokine signaling pathway_Homo sapiens_hsa040620.32650431
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31205411
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30966384
98Prion diseases_Homo sapiens_hsa050200.30473568
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.30164019
100Histidine metabolism_Homo sapiens_hsa003400.29303997
101Mineral absorption_Homo sapiens_hsa049780.28844350
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.28784113
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27641800
104Alzheimers disease_Homo sapiens_hsa050100.26616379
105Arginine biosynthesis_Homo sapiens_hsa002200.24753100
106AMPK signaling pathway_Homo sapiens_hsa041520.24600655
107Fatty acid biosynthesis_Homo sapiens_hsa000610.24483233
108beta-Alanine metabolism_Homo sapiens_hsa004100.22275967
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19948856
110HIF-1 signaling pathway_Homo sapiens_hsa040660.15216548
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13810363

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