IQUB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.88475691
2plasma membrane fusion (GO:0045026)9.68722108
3sperm-egg recognition (GO:0035036)9.53360547
4cell-cell recognition (GO:0009988)8.48066442
5acrosome reaction (GO:0007340)8.45533371
6binding of sperm to zona pellucida (GO:0007339)8.45011413
7reproduction (GO:0000003)8.25374335
8regulation of cilium movement (GO:0003352)7.91818010
9spermatid development (GO:0007286)7.70236440
10piRNA metabolic process (GO:0034587)7.58039154
11ventricular system development (GO:0021591)7.30420874
12male meiosis (GO:0007140)7.02359074
13single fertilization (GO:0007338)6.95693557
14axoneme assembly (GO:0035082)6.78713772
15synaptonemal complex organization (GO:0070193)6.41260157
16regulation of DNA methylation (GO:0044030)6.04647946
17synaptonemal complex assembly (GO:0007130)5.98490800
18fertilization (GO:0009566)5.72920710
19regulation of female gonad development (GO:2000194)5.72078532
20negative regulation of inclusion body assembly (GO:0090084)5.60222432
21retinal cone cell development (GO:0046549)5.36202680
22sperm capacitation (GO:0048240)5.35313705
23nucleoside diphosphate phosphorylation (GO:0006165)5.33234404
24male meiosis I (GO:0007141)5.27920183
25microtubule severing (GO:0051013)5.26551104
26intraciliary transport (GO:0042073)5.23950043
27spermatogenesis (GO:0007283)5.19524944
28male gamete generation (GO:0048232)5.17474931
29GTP biosynthetic process (GO:0006183)5.12845139
30microtubule depolymerization (GO:0007019)5.03004070
31DNA methylation involved in gamete generation (GO:0043046)4.88905035
32gamete generation (GO:0007276)4.78665433
33regulation of inclusion body assembly (GO:0090083)4.74878815
34spermatid nucleus differentiation (GO:0007289)4.73386647
35protein localization to cilium (GO:0061512)4.66047542
36regulation of microtubule-based movement (GO:0060632)4.60404736
37UTP biosynthetic process (GO:0006228)4.59916946
38cilium organization (GO:0044782)4.53181331
39female gamete generation (GO:0007292)4.50718394
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.40929511
41meiosis I (GO:0007127)4.40656715
42regulation of acrosome reaction (GO:0060046)4.33376850
43cell recognition (GO:0008037)4.32314312
44cilium assembly (GO:0042384)4.31228733
45germ cell development (GO:0007281)4.30599200
46calcium ion-dependent exocytosis (GO:0017156)4.26580138
47chromosome organization involved in meiosis (GO:0070192)4.22285303
48meiotic nuclear division (GO:0007126)4.18761780
49protein polyglutamylation (GO:0018095)4.18707836
50UTP metabolic process (GO:0046051)4.13949150
51meiotic cell cycle (GO:0051321)4.12116268
52microtubule-based movement (GO:0007018)3.99666041
53left/right axis specification (GO:0070986)3.99556440
54regulation of histone H3-K9 methylation (GO:0051570)3.98572844
55organic cation transport (GO:0015695)3.97081302
56cellular component assembly involved in morphogenesis (GO:0010927)3.96048921
57neuron fate determination (GO:0048664)3.95977600
58positive regulation of gastrulation (GO:2000543)3.94163296
59relaxation of smooth muscle (GO:0044557)3.91869653
60regulation of cell maturation (GO:1903429)3.90365914
61guanosine-containing compound biosynthetic process (GO:1901070)3.85961212
62left/right pattern formation (GO:0060972)3.83924094
63multicellular organismal reproductive process (GO:0048609)3.76377898
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.69691982
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69691982
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69691982
67centriole replication (GO:0007099)3.68460190
68monoubiquitinated protein deubiquitination (GO:0035520)3.66438850
69centriole assembly (GO:0098534)3.65452230
70oocyte development (GO:0048599)3.62672832
71* cilium morphogenesis (GO:0060271)3.59530809
72microtubule bundle formation (GO:0001578)3.59099032
73regulation of steroid hormone secretion (GO:2000831)3.52987307
74chaperone-mediated protein complex assembly (GO:0051131)3.52793761
75negative regulation of reproductive process (GO:2000242)3.48833428
76positive regulation of histone H3-K4 methylation (GO:0051571)3.35819404
77CTP biosynthetic process (GO:0006241)3.34299959
78CTP metabolic process (GO:0046036)3.34299959
79seminiferous tubule development (GO:0072520)3.29817349
80pyrimidine-containing compound transmembrane transport (GO:0072531)3.26999269
81primitive streak formation (GO:0090009)3.23152451
82regulation of centriole replication (GO:0046599)3.19497037
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.15614201
84determination of left/right symmetry (GO:0007368)3.12273840
85determination of bilateral symmetry (GO:0009855)3.08623373
86pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.07388963
87specification of symmetry (GO:0009799)3.04926528
88regulation of meiosis (GO:0040020)3.03369133
89somite rostral/caudal axis specification (GO:0032525)2.97903626
90nucleotide phosphorylation (GO:0046939)2.96892439
91glycine transport (GO:0015816)2.95872153
92negative regulation of histone methylation (GO:0031061)2.95856850
93genitalia morphogenesis (GO:0035112)2.93940712
94oogenesis (GO:0048477)2.88439883
95establishment of chromosome localization (GO:0051303)2.86568930
96multicellular organismal development (GO:0007275)2.84416425
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.82446115
98mitotic metaphase plate congression (GO:0007080)2.81592226
99cell projection assembly (GO:0030031)2.81521795
100glycerol ether metabolic process (GO:0006662)2.80501689
101alditol metabolic process (GO:0019400)2.78241235
102polyol catabolic process (GO:0046174)2.75197673
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74800510
104regulation of meiosis I (GO:0060631)2.73484692
105meiotic cell cycle process (GO:1903046)2.73251202
106peptidyl-threonine dephosphorylation (GO:0035970)2.72873373
107* smoothened signaling pathway (GO:0007224)2.68038910
108regulation of meiotic cell cycle (GO:0051445)2.67283440
109photoreceptor cell maintenance (GO:0045494)2.67187916
110reproductive system development (GO:0061458)2.66244891
111synapsis (GO:0007129)2.66186176
112organelle assembly (GO:0070925)2.65879792
113nonmotile primary cilium assembly (GO:0035058)2.65834969
114histone H2A acetylation (GO:0043968)2.65701917
115metaphase plate congression (GO:0051310)2.63959897
116negative regulation of organelle assembly (GO:1902116)2.63364250
117positive regulation of chromosome segregation (GO:0051984)2.62835739
118DNA alkylation (GO:0006305)2.61697213
119DNA methylation (GO:0006306)2.61697213
120nucleus organization (GO:0006997)2.61625303
121histone H3-K9 demethylation (GO:0033169)2.61170742
122gene silencing by RNA (GO:0031047)2.60386981
123nucleoside diphosphate metabolic process (GO:0009132)2.60056087
124ether metabolic process (GO:0018904)2.59800073
125microtubule polymerization or depolymerization (GO:0031109)2.59201506
126regulation of spindle checkpoint (GO:0090231)2.52914582
127protein refolding (GO:0042026)2.46184627
128glycerol metabolic process (GO:0006071)2.43620384
129microtubule-based process (GO:0007017)2.39419154
130protein K11-linked deubiquitination (GO:0035871)2.38252061
131cilium or flagellum-dependent cell motility (GO:0001539)15.4004810
132axonemal dynein complex assembly (GO:0070286)13.6617932
133fusion of sperm to egg plasma membrane (GO:0007342)12.6830255
134cilium movement (GO:0003341)11.6993493
135epithelial cilium movement (GO:0003351)11.3471450
136acrosome assembly (GO:0001675)10.7294086
137cell wall macromolecule metabolic process (GO:0044036)10.4084536
138cell wall macromolecule catabolic process (GO:0016998)10.4084536
139multicellular organism reproduction (GO:0032504)10.2578721
140motile cilium assembly (GO:0044458)10.2036124
141sperm motility (GO:0030317)10.0538648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.26632111
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.49117603
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.38636463
4EZH2_22144423_ChIP-Seq_EOC_Human4.38298500
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18752764
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.07051990
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.70594702
8GBX2_23144817_ChIP-Seq_PC3_Human3.00312329
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.88086876
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73915168
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.56514626
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35137242
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26458837
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.15949101
15ZNF274_21170338_ChIP-Seq_K562_Hela2.10889862
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01905952
17KAP1_22055183_ChIP-Seq_ESCs_Mouse2.00717628
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99454141
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.97524061
20EWS_26573619_Chip-Seq_HEK293_Human1.92707342
21P300_19829295_ChIP-Seq_ESCs_Human1.87628539
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87568517
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86288937
24* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.84916297
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.82430165
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.77863079
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76581431
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75561682
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74520840
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73867891
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.73410803
32* STAT3_23295773_ChIP-Seq_U87_Human1.68619328
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67923892
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67106176
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.67045121
36RNF2_27304074_Chip-Seq_NSC_Mouse1.65850894
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64322759
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62899815
39AR_25329375_ChIP-Seq_VCAP_Human1.62657664
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61857559
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.61559154
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58756361
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.57017243
44VDR_22108803_ChIP-Seq_LS180_Human1.54506192
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51514469
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50800760
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.50769827
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49533980
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49028232
50RUNX2_22187159_ChIP-Seq_PCA_Human1.48442142
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47016565
52* WDR5_24793694_ChIP-Seq_LNCAP_Human1.46290622
53IGF1R_20145208_ChIP-Seq_DFB_Human1.45901504
54AHR_22903824_ChIP-Seq_MCF-7_Human1.43800232
55STAT1_17558387_ChIP-Seq_HELA_Human1.41978444
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.40691243
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.40402790
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39990968
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.39213531
60REST_21632747_ChIP-Seq_MESCs_Mouse1.37890045
61GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37346620
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37075958
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36983029
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36983029
65P53_22387025_ChIP-Seq_ESCs_Mouse1.36972234
66KDM2B_26808549_Chip-Seq_REH_Human1.36528249
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36455315
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34940408
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.34930513
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.34864781
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.34859320
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33622063
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33155848
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33155848
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33155848
76TP53_16413492_ChIP-PET_HCT116_Human1.30631960
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29921394
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28971346
79CBP_20019798_ChIP-Seq_JUKART_Human1.27563861
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27563861
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27041901
82GATA3_21867929_ChIP-Seq_CD8_Mouse1.27001653
83TCF4_22108803_ChIP-Seq_LS180_Human1.26362937
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.23594706
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.23567654
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22978689
87P300_18555785_Chip-Seq_ESCs_Mouse1.22278951
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.21739630
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21536437
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20618664
91TAF15_26573619_Chip-Seq_HEK293_Human1.20531095
92SOX2_19829295_ChIP-Seq_ESCs_Human1.19599040
93NANOG_19829295_ChIP-Seq_ESCs_Human1.19599040
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.18820772
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17572781
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.17564840
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17537487
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17432453
99ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16126176
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16071949
101SMAD4_21799915_ChIP-Seq_A2780_Human1.15933495
102CDX2_22108803_ChIP-Seq_LS180_Human1.14683811
103ER_23166858_ChIP-Seq_MCF-7_Human1.13982396
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13715131
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.13294889
106DROSHA_22980978_ChIP-Seq_HELA_Human1.12025849
107LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11170561
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10771469
109GF1_26923725_Chip-Seq_HPCs_Mouse1.10622485
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.10144380
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10069980
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10065342
113GATA3_21867929_ChIP-Seq_TH1_Mouse1.09740447
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.08825270
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08509419
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08012063
117CBP_21632823_ChIP-Seq_H3396_Human1.06290969
118CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05915075
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04896251
120PU1_27457419_Chip-Seq_LIVER_Mouse1.04825491
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04684409
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.04524400
123BCAT_22108803_ChIP-Seq_LS180_Human1.04519903
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04495462
125TP53_18474530_ChIP-ChIP_U2OS_Human1.04046530
126FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03087760
127POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02714220
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02543580
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02508527
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.01701276
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01656549
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01375661
133SOX9_26525672_Chip-Seq_HEART_Mouse1.01022322
134IRF1_19129219_ChIP-ChIP_H3396_Human1.00632253
135AR_20517297_ChIP-Seq_VCAP_Human0.99610406
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99244484
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99190948
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.98933973
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.98800721
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98034174
141FUS_26573619_Chip-Seq_HEK293_Human0.97489221
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97298434
143TBL1_22424771_ChIP-Seq_293T_Human0.96584694
144ERG_20517297_ChIP-Seq_VCAP_Human0.96228304
145NFYB_21822215_ChIP-Seq_K562_Human0.95672835
146ESR1_20079471_ChIP-ChIP_T-47D_Human0.95069107
147* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94494007
148SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94490494
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94361822
150RXR_22108803_ChIP-Seq_LS180_Human0.94349284
151LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93849176
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.92922694
153TCF4_23295773_ChIP-Seq_U87_Human0.92431651
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92245941
155* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90774592
156* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89532303
157* FOXA1_25329375_ChIP-Seq_VCAP_Human0.89532303
158SALL4_22934838_ChIP-ChIP_CD34+_Human0.88304354
159JUN_21703547_ChIP-Seq_K562_Human0.87501500
160PHF8_20622853_ChIP-Seq_HELA_Human0.86809700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.22412048
2MP0001929_abnormal_gametogenesis4.78009919
3MP0002653_abnormal_ependyma_morphology4.75041734
4MP0008877_abnormal_DNA_methylation4.30017639
5MP0001984_abnormal_olfaction3.80867010
6MP0003136_yellow_coat_color3.78965249
7MP0002210_abnormal_sex_determination3.36062789
8MP0010030_abnormal_orbit_morphology3.22965165
9MP0005623_abnormal_meninges_morphology2.90031251
10MP0002161_abnormal_fertility/fecundity2.86719381
11MP0001145_abnormal_male_reproductive2.83645205
12MP0000653_abnormal_sex_gland2.52897048
13MP0002160_abnormal_reproductive_system2.42321102
14MP0000566_synostosis2.30764442
15MP0003890_abnormal_embryonic-extraembry2.29296860
16MP0005395_other_phenotype2.17898921
17MP0005410_abnormal_fertilization12.2885504
18MP0009046_muscle_twitch1.86395216
19MP0002139_abnormal_hepatobiliary_system1.72870458
20MP0002282_abnormal_trachea_morphology1.66671877
21MP0002102_abnormal_ear_morphology1.57684189
22MP0008057_abnormal_DNA_replication1.52378517
23MP0000631_abnormal_neuroendocrine_gland1.46784473
24MP0000383_abnormal_hair_follicle1.45981440
25MP0010678_abnormal_skin_adnexa1.43477022
26MP0008995_early_reproductive_senescence1.41378954
27MP0005389_reproductive_system_phenotype1.37360790
28MP0005670_abnormal_white_adipose1.29698767
29MP0008058_abnormal_DNA_repair1.25194967
30MP0000049_abnormal_middle_ear1.24840167
31MP0004133_heterotaxia1.20869725
32MP0008004_abnormal_stomach_pH1.19663041
33MP0003646_muscle_fatigue1.17989727
34MP0008875_abnormal_xenobiotic_pharmacok1.17961895
35MP0002138_abnormal_hepatobiliary_system1.15042473
36MP0004043_abnormal_pH_regulation1.14724700
37MP0003878_abnormal_ear_physiology1.13824580
38MP0005377_hearing/vestibular/ear_phenot1.13824580
39MP0003119_abnormal_digestive_system1.12531941
40MP0006276_abnormal_autonomic_nervous1.09736332
41MP0002928_abnormal_bile_duct1.08168160
42MP0001765_abnormal_ion_homeostasis1.06919968
43MP0005647_abnormal_sex_gland1.06837758
44MP0003183_abnormal_peptide_metabolism1.04830486
45MP0004142_abnormal_muscle_tone1.02288322
46MP0004233_abnormal_muscle_weight1.02106168
47MP0003950_abnormal_plasma_membrane1.01106924
48MP0000427_abnormal_hair_cycle0.99030208
49MP0003786_premature_aging0.98631403
50MP0000678_abnormal_parathyroid_gland0.96614519
51MP0002234_abnormal_pharynx_morphology0.95677798
52MP0003077_abnormal_cell_cycle0.95621274
53MP0001485_abnormal_pinna_reflex0.91596082
54MP0010234_abnormal_vibrissa_follicle0.89783355
55MP0001324_abnormal_eye_pigmentation0.89538514
56MP0002277_abnormal_respiratory_mucosa0.89307832
57MP0005551_abnormal_eye_electrophysiolog0.88138776
58MP0003121_genomic_imprinting0.84118664
59MP0005248_abnormal_Harderian_gland0.83863337
60MP0003195_calcinosis0.81352330
61MP0005360_urolithiasis0.80966168
62MP0002249_abnormal_larynx_morphology0.79619819
63MP0000762_abnormal_tongue_morphology0.77474907
64MP0003755_abnormal_palate_morphology0.76004533
65MP0004742_abnormal_vestibular_system0.74463313
66MP0002084_abnormal_developmental_patter0.74346888
67MP0005646_abnormal_pituitary_gland0.74149301
68MP0003283_abnormal_digestive_organ0.73933407
69MP0005085_abnormal_gallbladder_physiolo0.73594774
70MP0003011_delayed_dark_adaptation0.72599985
71MP0010094_abnormal_chromosome_stability0.72430611
72MP0003937_abnormal_limbs/digits/tail_de0.72301865
73MP0009780_abnormal_chondrocyte_physiolo0.70270784
74MP0004019_abnormal_vitamin_homeostasis0.70186170
75MP0004381_abnormal_hair_follicle0.70112307
76MP0000778_abnormal_nervous_system0.70034017
77MP0003252_abnormal_bile_duct0.68564265
78MP0001661_extended_life_span0.68412615
79MP0001293_anophthalmia0.68193347
80MP0003879_abnormal_hair_cell0.68161427
81MP0001529_abnormal_vocalization0.67770322
82MP0003861_abnormal_nervous_system0.67069171
83MP0003718_maternal_effect0.66673533
84MP0002152_abnormal_brain_morphology0.66027140
85MP0002751_abnormal_autonomic_nervous0.65477820
86MP0001486_abnormal_startle_reflex0.65287647
87MP0004858_abnormal_nervous_system0.64993543
88MP0008789_abnormal_olfactory_epithelium0.64963874
89MP0003938_abnormal_ear_development0.64740146
90MP0001440_abnormal_grooming_behavior0.64220899
91MP0005499_abnormal_olfactory_system0.63988169
92MP0005394_taste/olfaction_phenotype0.63988169
93MP0005423_abnormal_somatic_nervous0.63219261
94MP0002557_abnormal_social/conspecific_i0.62539105
95MP0001286_abnormal_eye_development0.62374181
96MP0005187_abnormal_penis_morphology0.60408784
97MP0001502_abnormal_circadian_rhythm0.59401647
98MP0005171_absent_coat_pigmentation0.59371978
99MP0003935_abnormal_craniofacial_develop0.59170482
100MP0002752_abnormal_somatic_nervous0.59114951
101MP0006292_abnormal_olfactory_placode0.57888183
102MP0002572_abnormal_emotion/affect_behav0.57280302
103MP0004270_analgesia0.56761321
104MP0002734_abnormal_mechanical_nocicepti0.56167767
105MP0005391_vision/eye_phenotype0.56039664
106MP0003699_abnormal_female_reproductive0.55862389
107MP0002971_abnormal_brown_adipose0.54743882
108MP0003635_abnormal_synaptic_transmissio0.54742464
109MP0000026_abnormal_inner_ear0.53377721
110MP0003111_abnormal_nucleus_morphology0.52801990
111MP0005253_abnormal_eye_physiology0.52383271
112MP0001119_abnormal_female_reproductive0.52015323
113MP0000647_abnormal_sebaceous_gland0.51791000
114MP0009745_abnormal_behavioral_response0.51268897
115MP0005636_abnormal_mineral_homeostasis0.49342079
116MP0003634_abnormal_glial_cell0.49221222
117MP0001919_abnormal_reproductive_system0.49212821
118MP0004859_abnormal_synaptic_plasticity0.49101141
119MP0008007_abnormal_cellular_replicative0.46856871
120MP0002272_abnormal_nervous_system0.46840711
121MP0002092_abnormal_eye_morphology0.45780507
122MP0002233_abnormal_nose_morphology0.45643197
123MP0002132_abnormal_respiratory_system0.45230605
124MP0005388_respiratory_system_phenotype0.44650320
125MP0002133_abnormal_respiratory_system0.44650320
126MP0001963_abnormal_hearing_physiology0.44229066
127MP0001968_abnormal_touch/_nociception0.44207730
128MP0002882_abnormal_neuron_morphology0.43093984
129MP0003115_abnormal_respiratory_system0.43014912
130MP0000432_abnormal_head_morphology0.42823468
131MP0002067_abnormal_sensory_capabilities0.42668084
132MP0002064_seizures0.42005168
133MP0003693_abnormal_embryo_hatching0.41396432
134MP0005195_abnormal_posterior_eye0.40993889
135MP0002638_abnormal_pupillary_reflex0.40904465
136MP0003942_abnormal_urinary_system0.38941976
137MP0001986_abnormal_taste_sensitivity0.38929986
138MP0006072_abnormal_retinal_apoptosis0.37906021
139MP0002938_white_spotting0.36949360
140MP0003329_amyloid_beta_deposits0.36913888
141MP0002063_abnormal_learning/memory/cond0.36591309

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.46919795
2Abnormal respiratory epithelium morphology (HP:0012253)9.46919795
3Rhinitis (HP:0012384)9.12552344
4Chronic bronchitis (HP:0004469)7.29034095
5Nasal polyposis (HP:0100582)5.95247780
6Bronchiectasis (HP:0002110)5.34667559
7Infertility (HP:0000789)5.12124334
8Abnormality of the nasal mucosa (HP:0000433)4.83661631
9Bronchitis (HP:0012387)4.13262567
10Nephronophthisis (HP:0000090)3.89959803
11Recurrent sinusitis (HP:0011108)3.75562795
12Medial flaring of the eyebrow (HP:0010747)3.25189494
13Pancreatic fibrosis (HP:0100732)3.17176437
14Recurrent otitis media (HP:0000403)3.16668919
15Abnormality of midbrain morphology (HP:0002418)3.12388729
16Molar tooth sign on MRI (HP:0002419)3.12388729
17Abnormality of abdominal situs (HP:0011620)3.02299390
18Abdominal situs inversus (HP:0003363)3.02299390
19Abnormality of the renal medulla (HP:0100957)2.98695573
20Male infertility (HP:0003251)2.87460430
21Tubulointerstitial nephritis (HP:0001970)2.80830069
22Facial hemangioma (HP:0000329)2.70633797
23True hermaphroditism (HP:0010459)2.69451935
24Gait imbalance (HP:0002141)2.59462298
25Septo-optic dysplasia (HP:0100842)2.58680016
26Congenital primary aphakia (HP:0007707)2.57668518
27Fibular hypoplasia (HP:0003038)2.57110864
28Chronic sinusitis (HP:0011109)2.54865970
29Oligodactyly (hands) (HP:0001180)2.46113822
30Median cleft lip (HP:0000161)2.42407012
31Postaxial foot polydactyly (HP:0001830)2.41382172
32Short tibia (HP:0005736)2.37863452
33Abnormality of the labia minora (HP:0012880)2.36932176
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.30541458
35Abnormal spermatogenesis (HP:0008669)2.25800721
36Supernumerary spleens (HP:0009799)2.25634931
37Nephrogenic diabetes insipidus (HP:0009806)2.22713611
38Congenital hepatic fibrosis (HP:0002612)2.21284096
39Absent septum pellucidum (HP:0001331)2.15175506
40Pancreatic cysts (HP:0001737)2.14848382
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.13666410
42Facial cleft (HP:0002006)2.13418333
43Poor coordination (HP:0002370)2.07839729
44Papillary thyroid carcinoma (HP:0002895)2.07726470
45Osteomalacia (HP:0002749)2.06164530
46Abnormality of permanent molar morphology (HP:0011071)2.05391215
47Abnormality of the dental root (HP:0006486)2.05391215
48Taurodontia (HP:0000679)2.05391215
49Genital tract atresia (HP:0001827)2.03666867
50Recurrent bronchitis (HP:0002837)2.02748214
51Cystic liver disease (HP:0006706)2.01962218
52Tubulointerstitial abnormality (HP:0001969)2.00749588
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8400618
54Abnormal respiratory motile cilium physiology (HP:0012261)11.2244852
55Dynein arm defect of respiratory motile cilia (HP:0012255)11.1680975
56Absent/shortened dynein arms (HP:0200106)11.1680975
57Abnormal ciliary motility (HP:0012262)10.2674114
58Postaxial hand polydactyly (HP:0001162)1.98612693
59Impulsivity (HP:0100710)1.97614686
60Abnormality of the dental pulp (HP:0006479)1.94985296
61Occipital encephalocele (HP:0002085)1.92836165
62Tubular atrophy (HP:0000092)1.92498305
63Abnormality of molar (HP:0011077)1.92098842
64Abnormality of molar morphology (HP:0011070)1.92098842
65Vaginal atresia (HP:0000148)1.90215229
66Lip pit (HP:0100267)1.86739290
67Maternal diabetes (HP:0009800)1.85944246
68Abnormality of the septum pellucidum (HP:0007375)1.84878474
69Stage 5 chronic kidney disease (HP:0003774)1.82668317
70Oculomotor apraxia (HP:0000657)1.82184184
71Azoospermia (HP:0000027)1.81937161
72Furrowed tongue (HP:0000221)1.78994950
73Aplasia/Hypoplasia of the fibula (HP:0006492)1.77029955
74Anterior segment dysgenesis (HP:0007700)1.76243740
75Abnormality of dentin (HP:0010299)1.72520891
76Microglossia (HP:0000171)1.69750633
77Optic nerve hypoplasia (HP:0000609)1.69294959
78Abnormal biliary tract physiology (HP:0012439)1.69004117
79Bile duct proliferation (HP:0001408)1.69004117
80Aplasia/Hypoplasia of the lens (HP:0008063)1.67349026
81Oligodactyly (HP:0012165)1.67261738
82Hypoplasia of the fovea (HP:0007750)1.65692909
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.65692909
84Hypophosphatemic rickets (HP:0004912)1.65555452
85Bifid tongue (HP:0010297)1.65233578
86Chronic otitis media (HP:0000389)1.62788590
87Narrow forehead (HP:0000341)1.60104992
88Hyperactive renin-angiotensin system (HP:0000841)1.60001507
89Anencephaly (HP:0002323)1.57811122
90Gonadotropin excess (HP:0000837)1.55350341
91Chronic hepatic failure (HP:0100626)1.55135598
92Abnormality of the fovea (HP:0000493)1.51286565
93Abnormality of the lower motor neuron (HP:0002366)1.49976826
94Bony spicule pigmentary retinopathy (HP:0007737)1.48457202
95Cone-rod dystrophy (HP:0000548)1.47993612
96Prominent nasal bridge (HP:0000426)1.47674427
97Renal dysplasia (HP:0000110)1.46696249
98Amyotrophic lateral sclerosis (HP:0007354)1.45676256
99Multicystic kidney dysplasia (HP:0000003)1.44139796
100Abnormality of the labia (HP:0000058)1.43452011
101Short ribs (HP:0000773)1.43082027
102Short nail (HP:0001799)1.42655306
103Retinal dysplasia (HP:0007973)1.42597345
104Anophthalmia (HP:0000528)1.42514597
105Decreased central vision (HP:0007663)1.42062889
106Hypoplastic labia majora (HP:0000059)1.41882730
107Fair hair (HP:0002286)1.41469593
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.41332981
109Male pseudohermaphroditism (HP:0000037)1.40785523
110Preaxial hand polydactyly (HP:0001177)1.38069670
111Bicornuate uterus (HP:0000813)1.37925438
112Abnormality of the renal cortex (HP:0011035)1.37922042
113Holoprosencephaly (HP:0001360)1.37129862
114Tubulointerstitial fibrosis (HP:0005576)1.37116852
115Highly arched eyebrow (HP:0002553)1.36680494
116Ventricular fibrillation (HP:0001663)1.29501690
117Sclerocornea (HP:0000647)1.29462590
118Nephropathy (HP:0000112)1.26527064
11911 pairs of ribs (HP:0000878)1.22750231
120Polydipsia (HP:0001959)1.22527897
121Abnormal drinking behavior (HP:0030082)1.22527897
122Abnormality of renal excretion (HP:0011036)1.21619715
123Broad distal phalanx of finger (HP:0009836)1.21182484
124Atelectasis (HP:0100750)1.21117440
125Broad foot (HP:0001769)1.20285721
126Dental crowding (HP:0000678)1.20262123
127Bell-shaped thorax (HP:0001591)1.18884230
128Abnormality of macular pigmentation (HP:0008002)1.16419832
129Retinitis pigmentosa (HP:0000510)1.14261335
130J-shaped sella turcica (HP:0002680)1.13691686
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.12853832
132Hypodontia (HP:0000668)1.11666325
133Aganglionic megacolon (HP:0002251)1.11260681
134Transposition of the great arteries (HP:0001669)1.10423054
135Abnormal connection of the cardiac segments (HP:0011545)1.10423054
136Abnormal ventriculo-arterial connection (HP:0011563)1.10423054
137Short thorax (HP:0010306)1.07946486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.18441555
2PDK38.18441555
3PDK25.32419131
4PNCK4.06832184
5MAPK153.54720775
6TESK13.10380223
7ARAF2.86968449
8PRKD32.82168155
9MAP4K22.63790677
10MAP3K92.49655214
11STK392.45045380
12CDK192.44155210
13TNIK2.25787888
14MET2.18837287
15WNK42.17668788
16STK242.15520526
17CDK92.04437191
18PTK2B2.00777713
19ICK1.94256957
20WEE11.76237141
21NEK21.66053747
22MAP3K131.61683703
23BMPR1B1.59734894
24ZAK1.55878827
25WNK31.50318925
26DYRK31.49755968
27MAPKAPK31.47003882
28TRIM281.40076964
29NEK91.39230859
30FRK1.35108300
31TAOK31.33442945
32MOS1.32586266
33LATS11.24734762
34IRAK11.24394343
35STK381.16069338
36RAF11.15810584
37EIF2AK31.12730594
38TSSK61.12148219
39NUAK11.08074927
40NTRK21.04032086
41MAPK131.00197908
42TLK10.98137462
43PLK40.97662777
44INSRR0.96716965
45ACVR1B0.96170429
46PLK20.93970628
47KSR20.92823661
48PINK10.92168200
49LMTK20.91551724
50BCR0.90181945
51WNK10.88514728
52TTK0.87702937
53STK38L0.86594513
54CDK120.86458117
55STK30.85149074
56BRD40.83834661
57CDK30.82297043
58CHEK20.80555919
59BRSK20.79840113
60KSR10.79522847
61GRK10.79138546
62BUB10.78484381
63OXSR10.72489284
64ERBB30.72473230
65CCNB10.71321600
66PDK10.71058022
67TYRO30.70700071
68PRKCG0.69220063
69TGFBR10.67199121
70TIE10.67158799
71CASK0.63602267
72PAK20.62400935
73MKNK20.61845205
74CDK80.58755238
75DYRK1B0.55052943
76MST40.54816029
77CDK70.54589231
78MELK0.53812435
79PLK10.53496889
80AURKA0.50805706
81MAP3K20.50671616
82NTRK30.49217310
83AKT30.47656053
84CHEK10.46171327
85MAP2K70.46055251
86CAMK1G0.43961129
87CAMKK10.43604311
88NEK60.43193464
89NME10.42979566
90PLK30.42944282
91CDC70.42161844
92CSNK1G30.41569961
93DMPK0.39927043
94CHUK0.39266972
95MUSK0.39020653
96PBK0.38823496
97AKT20.38157344
98CDK20.37739166
99EPHA40.37322283
100PHKG10.36713439
101PHKG20.36713439
102CDK10.36619669
103MARK10.36001493
104CSNK1A1L0.35110000
105MAP2K20.34990978
106STK100.34214266
107STK160.33802366
108PRKACB0.33457337
109MAP3K40.32745636
110TESK20.31524424
111PRKAA10.30437558
112PAK10.29897976
113ATM0.28865984
114VRK10.28805519
115BRSK10.28612871
116IRAK20.26289811
117PASK0.25071010
118PDPK10.24432703
119CAMK2B0.23320740
120ATR0.22672928
121MAPK100.22661303
122CAMK2A0.22611677
123GSK3A0.22452635
124MARK30.21743226
125PRKG10.20983168
126CSNK1E0.20568680
127GRK50.18963289
128CAMKK20.18740032
129CAMK2G0.17755430
130BRAF0.17570087
131SRPK10.17068913
132DYRK1A0.16790874
133AURKB0.16629992
134CSNK1G10.15780082
135CSNK1G20.15535700
136YES10.14726749
137PRKACA0.13677152
138RIPK40.13563392
139LATS20.13515603
140STK110.13391866
141PRKACG0.13331489
142MAPKAPK50.13114647
143DYRK20.12844401
144PRKCI0.12356073
145CSNK1D0.12330041
146CSNK2A10.11830786
147PRKAA20.11583408
148CAMK2D0.11412241
149PKN10.11180646
150PAK30.10984051
151CSNK2A20.10033244

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.18277466
2Basal transcription factors_Homo sapiens_hsa030222.95917443
3Pyruvate metabolism_Homo sapiens_hsa006202.95424991
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.73575332
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.65969454
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.48985422
7Olfactory transduction_Homo sapiens_hsa047402.48455166
8Propanoate metabolism_Homo sapiens_hsa006402.43748756
9Caffeine metabolism_Homo sapiens_hsa002322.41119386
10Fatty acid biosynthesis_Homo sapiens_hsa000612.40843403
11Pentose phosphate pathway_Homo sapiens_hsa000302.26423867
12Fanconi anemia pathway_Homo sapiens_hsa034602.19715212
13Glucagon signaling pathway_Homo sapiens_hsa049222.18992984
14Huntingtons disease_Homo sapiens_hsa050162.18990828
15Amphetamine addiction_Homo sapiens_hsa050312.02216874
16Oocyte meiosis_Homo sapiens_hsa041142.02090602
17Mismatch repair_Homo sapiens_hsa034301.89394614
18ABC transporters_Homo sapiens_hsa020101.86988968
19RNA degradation_Homo sapiens_hsa030181.79068562
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.74624439
21Purine metabolism_Homo sapiens_hsa002301.71586519
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64805730
23Glycerolipid metabolism_Homo sapiens_hsa005611.57731602
24Linoleic acid metabolism_Homo sapiens_hsa005911.57423394
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.57018688
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53414161
27Mineral absorption_Homo sapiens_hsa049781.52196616
28Dorso-ventral axis formation_Homo sapiens_hsa043201.49771462
29Nitrogen metabolism_Homo sapiens_hsa009101.48691327
30Gap junction_Homo sapiens_hsa045401.46935108
31Butanoate metabolism_Homo sapiens_hsa006501.44447592
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38427305
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37011036
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.36809632
35PPAR signaling pathway_Homo sapiens_hsa033201.34398544
36Renin secretion_Homo sapiens_hsa049241.31491237
37RNA transport_Homo sapiens_hsa030131.31478498
38Selenocompound metabolism_Homo sapiens_hsa004501.29938715
39Steroid biosynthesis_Homo sapiens_hsa001001.29423919
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.24349635
41Histidine metabolism_Homo sapiens_hsa003401.24099514
42Calcium signaling pathway_Homo sapiens_hsa040201.20968581
43Ether lipid metabolism_Homo sapiens_hsa005651.15004407
44Taste transduction_Homo sapiens_hsa047421.10228308
45Cardiac muscle contraction_Homo sapiens_hsa042601.06305862
46Phototransduction_Homo sapiens_hsa047441.06240272
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05087370
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03217084
49Phenylalanine metabolism_Homo sapiens_hsa003601.02640664
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01975356
51Long-term potentiation_Homo sapiens_hsa047201.01531640
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00597656
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99736084
54Pyrimidine metabolism_Homo sapiens_hsa002400.98911057
55Insulin secretion_Homo sapiens_hsa049110.98100683
56Hedgehog signaling pathway_Homo sapiens_hsa043400.97486587
57beta-Alanine metabolism_Homo sapiens_hsa004100.96996204
58Tyrosine metabolism_Homo sapiens_hsa003500.94495610
59Gastric acid secretion_Homo sapiens_hsa049710.94060306
60TGF-beta signaling pathway_Homo sapiens_hsa043500.93504197
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93193944
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.93015237
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.92469894
64Glutamatergic synapse_Homo sapiens_hsa047240.90437052
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.88389039
66p53 signaling pathway_Homo sapiens_hsa041150.86954071
67Circadian entrainment_Homo sapiens_hsa047130.86884927
68Basal cell carcinoma_Homo sapiens_hsa052170.86109269
69RNA polymerase_Homo sapiens_hsa030200.83868261
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83151795
71GABAergic synapse_Homo sapiens_hsa047270.82834572
72mRNA surveillance pathway_Homo sapiens_hsa030150.82418782
73Hippo signaling pathway_Homo sapiens_hsa043900.81455784
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81295104
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80880176
76Circadian rhythm_Homo sapiens_hsa047100.80337185
77Carbon metabolism_Homo sapiens_hsa012000.80198489
78Salivary secretion_Homo sapiens_hsa049700.79843735
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79291250
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79047780
81Estrogen signaling pathway_Homo sapiens_hsa049150.77370991
82Nicotine addiction_Homo sapiens_hsa050330.77107507
83Glutathione metabolism_Homo sapiens_hsa004800.73994292
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73409648
85Arachidonic acid metabolism_Homo sapiens_hsa005900.72013398
86Arginine and proline metabolism_Homo sapiens_hsa003300.72010081
87cAMP signaling pathway_Homo sapiens_hsa040240.71480245
88Folate biosynthesis_Homo sapiens_hsa007900.71137880
89Morphine addiction_Homo sapiens_hsa050320.70021433
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69656707
91Wnt signaling pathway_Homo sapiens_hsa043100.69543123
92Serotonergic synapse_Homo sapiens_hsa047260.67441607
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65683285
94Homologous recombination_Homo sapiens_hsa034400.65667802
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65501428
96Regulation of autophagy_Homo sapiens_hsa041400.64805810
97Inositol phosphate metabolism_Homo sapiens_hsa005620.64492538
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64467284
99Nucleotide excision repair_Homo sapiens_hsa034200.63640016
100Cocaine addiction_Homo sapiens_hsa050300.63545860
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62555764
102Cell cycle_Homo sapiens_hsa041100.60428321
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59491725
104Thyroid hormone synthesis_Homo sapiens_hsa049180.59161762
105Biosynthesis of amino acids_Homo sapiens_hsa012300.58332008
106Fructose and mannose metabolism_Homo sapiens_hsa000510.58070212
107Vitamin digestion and absorption_Homo sapiens_hsa049770.57667579
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57352763
109Sphingolipid metabolism_Homo sapiens_hsa006000.56370117
110Collecting duct acid secretion_Homo sapiens_hsa049660.54601900
111Tight junction_Homo sapiens_hsa045300.52894714
112Antigen processing and presentation_Homo sapiens_hsa046120.52654403
113Peroxisome_Homo sapiens_hsa041460.52575718
114Base excision repair_Homo sapiens_hsa034100.51072823
115Dopaminergic synapse_Homo sapiens_hsa047280.51033931
116Metabolic pathways_Homo sapiens_hsa011000.50884473
117Retinol metabolism_Homo sapiens_hsa008300.48385927
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47582312
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47183276
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46025063
121Pancreatic secretion_Homo sapiens_hsa049720.45710205
122Renin-angiotensin system_Homo sapiens_hsa046140.44315104
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42678183
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42435967
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42385649
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42107885
127Chemical carcinogenesis_Homo sapiens_hsa052040.41504274
128Adherens junction_Homo sapiens_hsa045200.41214517
129Parkinsons disease_Homo sapiens_hsa050120.40992070
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40692005
131Oxidative phosphorylation_Homo sapiens_hsa001900.39857672
132Alcoholism_Homo sapiens_hsa050340.39476788
133Synaptic vesicle cycle_Homo sapiens_hsa047210.38602529
134Bile secretion_Homo sapiens_hsa049760.37776115
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37658822
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.36856385
137Protein export_Homo sapiens_hsa030600.35885056
138Ovarian steroidogenesis_Homo sapiens_hsa049130.35856316
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35274520
140Fat digestion and absorption_Homo sapiens_hsa049750.34968584
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32067258
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31377851
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31077990
144AMPK signaling pathway_Homo sapiens_hsa041520.30104603
145Oxytocin signaling pathway_Homo sapiens_hsa049210.29791275
146Systemic lupus erythematosus_Homo sapiens_hsa053220.28593305
147N-Glycan biosynthesis_Homo sapiens_hsa005100.28433987

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