IRAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.44632809
2DNA deamination (GO:0045006)4.96647017
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26680891
4ribosomal small subunit assembly (GO:0000028)4.17638174
5protein localization to endosome (GO:0036010)4.16916247
6protein targeting to ER (GO:0045047)4.15966766
7ribosomal small subunit biogenesis (GO:0042274)4.14052780
8cotranslational protein targeting to membrane (GO:0006613)4.12992979
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.09304122
10signal peptide processing (GO:0006465)4.02157623
11activation of Rac GTPase activity (GO:0032863)4.01459524
12Golgi transport vesicle coating (GO:0048200)3.99954161
13COPI coating of Golgi vesicle (GO:0048205)3.99954161
14establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93222140
15protein localization to endoplasmic reticulum (GO:0070972)3.89204500
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85933939
17regulation of early endosome to late endosome transport (GO:2000641)3.78216466
18mitochondrial DNA replication (GO:0006264)3.76495526
19pentose-phosphate shunt (GO:0006098)3.75344174
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.74267007
21maturation of SSU-rRNA (GO:0030490)3.73968335
22telomere maintenance via semi-conservative replication (GO:0032201)3.69419799
23viral transcription (GO:0019083)3.67168014
24negative regulation of cell size (GO:0045792)3.67092453
25regulation of glucose import in response to insulin stimulus (GO:2001273)3.59317738
26mitotic chromosome condensation (GO:0007076)3.53597346
27apoptotic process involved in morphogenesis (GO:0060561)3.52714741
28glucose catabolic process (GO:0006007)3.52354198
29regulation of translational fidelity (GO:0006450)3.50906741
30DNA unwinding involved in DNA replication (GO:0006268)3.48978749
31translational termination (GO:0006415)3.48337899
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38945742
33ribosomal large subunit biogenesis (GO:0042273)3.36386217
34positive regulation of Cdc42 GTPase activity (GO:0043089)3.34663508
35telomere maintenance via recombination (GO:0000722)3.31697839
36DNA-dependent DNA replication (GO:0006261)3.31242913
37negative regulation of erythrocyte differentiation (GO:0045647)3.30849005
38glucose 6-phosphate metabolic process (GO:0051156)3.29849461
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21865679
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21865679
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21720514
42histone H4-K12 acetylation (GO:0043983)3.18034002
43cell-substrate adherens junction assembly (GO:0007045)3.17298360
44focal adhesion assembly (GO:0048041)3.17298360
45NADPH regeneration (GO:0006740)3.16898661
46regulation of translational termination (GO:0006449)3.16418255
47maternal placenta development (GO:0001893)3.15603361
48pinocytosis (GO:0006907)3.13819513
49DNA replication checkpoint (GO:0000076)3.13390219
50adherens junction assembly (GO:0034333)3.11939062
51translational elongation (GO:0006414)3.11411790
52antigen processing and presentation of endogenous antigen (GO:0019883)3.08161751
53translation (GO:0006412)3.06828229
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.06794317
55DNA strand elongation involved in DNA replication (GO:0006271)3.04756053
56RNA destabilization (GO:0050779)3.04092455
57cell-substrate junction assembly (GO:0007044)3.01676165
58protein retention in ER lumen (GO:0006621)3.00026474
59ribosome assembly (GO:0042255)2.99442314
60desmosome organization (GO:0002934)2.98531069
61hemidesmosome assembly (GO:0031581)2.96755364
62rRNA modification (GO:0000154)2.95684477
63ribonucleoprotein complex biogenesis (GO:0022613)2.95160175
64germinal center formation (GO:0002467)2.93798358
65epithelial cell-cell adhesion (GO:0090136)2.92901221
66positive regulation of keratinocyte differentiation (GO:0045618)2.90310772
67DNA strand elongation (GO:0022616)2.89779677
68translational initiation (GO:0006413)2.89444717
69GDP-mannose metabolic process (GO:0019673)2.87908421
70natural killer cell activation involved in immune response (GO:0002323)2.86126112
71mitotic recombination (GO:0006312)2.84925965
72modulation by symbiont of host cellular process (GO:0044068)2.84840107
73DNA damage response, detection of DNA damage (GO:0042769)2.82457649
74tRNA methylation (GO:0030488)2.81237968
75nuclear envelope reassembly (GO:0031468)2.80660884
76mitotic nuclear envelope reassembly (GO:0007084)2.80660884
77negative regulation of phagocytosis (GO:0050765)2.80482173
78cellular protein complex localization (GO:0034629)2.78349072
79valine metabolic process (GO:0006573)2.78217099
80regulation of antigen processing and presentation (GO:0002577)2.77560990
81branching involved in mammary gland duct morphogenesis (GO:0060444)2.77483449
82RNA methylation (GO:0001510)2.77034067
83mitochondrial DNA metabolic process (GO:0032042)2.76765681
84negative regulation of fatty acid transport (GO:2000192)2.76647508
85telomere maintenance via telomere lengthening (GO:0010833)2.75618244
86regulation of apoptotic process involved in morphogenesis (GO:1902337)2.74904545
87positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74875560
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74249116
89glycolipid catabolic process (GO:0019377)2.73780429
90viral life cycle (GO:0019058)2.72336017
91proteasome assembly (GO:0043248)2.72018172
92mannose metabolic process (GO:0006013)2.70747135
93mRNA modification (GO:0016556)2.68777538
94epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68732451
95negative regulation of viral release from host cell (GO:1902187)2.63453778
96folic acid-containing compound biosynthetic process (GO:0009396)2.62364409
97DNA synthesis involved in DNA repair (GO:0000731)2.61338652
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.61305908
99sequestering of metal ion (GO:0051238)2.60782628
100nucleobase-containing small molecule interconversion (GO:0015949)2.60775931
101DNA damage induced protein phosphorylation (GO:0006975)2.60716705
102ceramide catabolic process (GO:0046514)2.60191737
103endocrine pancreas development (GO:0031018)2.57975871
104stress fiber assembly (GO:0043149)2.57928987
105peptidyl-arginine omega-N-methylation (GO:0035247)2.57787237
106barbed-end actin filament capping (GO:0051016)2.57608601
1073-UTR-mediated mRNA stabilization (GO:0070935)2.56232957
108deoxyribonucleotide biosynthetic process (GO:0009263)2.56103002
109glycosphingolipid catabolic process (GO:0046479)2.54755923
110modulation by virus of host process (GO:0019054)2.53423594
111IMP biosynthetic process (GO:0006188)2.53024419
112pteridine-containing compound biosynthetic process (GO:0042559)2.52632191
113protein targeting to membrane (GO:0006612)2.52315643
114pentose metabolic process (GO:0019321)2.52069608
115embryonic process involved in female pregnancy (GO:0060136)2.51236328
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.51102367
117termination of RNA polymerase III transcription (GO:0006386)2.51102367
118skin morphogenesis (GO:0043589)2.49681991
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47951763
120DNA replication initiation (GO:0006270)2.47935151
121ER-nucleus signaling pathway (GO:0006984)2.47772055
122semaphorin-plexin signaling pathway (GO:0071526)2.47500766
123endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46494009
124protein complex localization (GO:0031503)2.46094718
125deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.46000504
126nuclear pore complex assembly (GO:0051292)2.45443702
127regulation of histone H3-K27 methylation (GO:0061085)2.45051266
128formation of translation preinitiation complex (GO:0001731)2.44960806
129heterochromatin organization (GO:0070828)2.44635882
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43450307
131activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42852458
132regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.42068342
133cellular protein complex disassembly (GO:0043624)2.41034112
134positive regulation of nuclease activity (GO:0032075)2.40918468
135basement membrane organization (GO:0071711)2.40770933
136NIK/NF-kappaB signaling (GO:0038061)2.40436516
137amyloid precursor protein catabolic process (GO:0042987)2.40422844
138modulation by virus of host morphology or physiology (GO:0019048)2.39956219
139regulation of integrin activation (GO:0033623)2.39917945
140positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39579055
141response to laminar fluid shear stress (GO:0034616)2.39513949
142regulation of mitochondrial translation (GO:0070129)2.39386523
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.39280453
144rRNA processing (GO:0006364)2.39045488
145protein localization to microtubule (GO:0035372)2.38861536
146pseudouridine synthesis (GO:0001522)2.38076013
147RNA stabilization (GO:0043489)2.35820164
148mRNA stabilization (GO:0048255)2.35820164
149activation of MAPKKK activity (GO:0000185)2.35581987
150positive regulation of histone deacetylation (GO:0031065)2.35349526
151negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.34968956
152UV protection (GO:0009650)2.34639695
153proline metabolic process (GO:0006560)2.33042215
154oligosaccharide catabolic process (GO:0009313)2.32588770
155protein maturation by protein folding (GO:0022417)2.32277333
156regulation of nuclease activity (GO:0032069)2.32122556
157positive regulation of DNA-dependent DNA replication (GO:2000105)2.31858125
158regulation of superoxide anion generation (GO:0032928)2.31757356
159ribosome biogenesis (GO:0042254)2.31480109
160cellular response to unfolded protein (GO:0034620)2.31130691
161rRNA metabolic process (GO:0016072)2.30125671
162COPII vesicle coating (GO:0048208)2.30052210
163nucleotide-excision repair, DNA gap filling (GO:0006297)2.29764461
164regulation of cholesterol biosynthetic process (GO:0045540)2.29374573
165regulation of NFAT protein import into nucleus (GO:0051532)2.28936410
166protein export from nucleus (GO:0006611)2.28793585
167exocrine pancreas development (GO:0031017)2.28594404
168vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28095421
169nuclear-transcribed mRNA catabolic process (GO:0000956)2.27209944
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.26506709
171folic acid metabolic process (GO:0046655)2.25810342
172intracellular estrogen receptor signaling pathway (GO:0030520)2.25744054
173transcription-coupled nucleotide-excision repair (GO:0006283)2.25439045
174regulation of chromatin binding (GO:0035561)2.23187133
175dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22291119
176negative regulation of bone resorption (GO:0045779)2.22222452
177regulation of translation in response to stress (GO:0043555)2.22191960
178endoplasmic reticulum unfolded protein response (GO:0030968)2.21503819
179cellular component biogenesis (GO:0044085)2.20009226
180neutrophil mediated immunity (GO:0002446)2.19109669
181glandular epithelial cell differentiation (GO:0002067)2.18152749
182proline biosynthetic process (GO:0006561)2.17979241
183mRNA catabolic process (GO:0006402)2.17817805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.00417069
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.41610969
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27181273
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18235504
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.13923389
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.04232332
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88556153
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.82649310
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.62939566
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57696440
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.41299838
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40141789
13ZNF263_19887448_ChIP-Seq_K562_Human2.38918436
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34857830
15LXR_22292898_ChIP-Seq_THP-1_Human2.31692723
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.31264223
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28122211
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27355087
19VDR_23849224_ChIP-Seq_CD4+_Human2.23543649
20GATA1_22025678_ChIP-Seq_K562_Human2.21627953
21RACK7_27058665_Chip-Seq_MCF-7_Human2.17969255
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10802572
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09285553
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08211425
25CIITA_25753668_ChIP-Seq_RAJI_Human2.06142176
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05770615
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04530815
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03275381
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.00910694
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99291220
31FOXP3_21729870_ChIP-Seq_TREG_Human1.97351268
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97303532
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96559845
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94555208
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92319068
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90856543
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87924558
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80962101
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80621734
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74198000
41XRN2_22483619_ChIP-Seq_HELA_Human1.71982070
42ELK1_19687146_ChIP-ChIP_HELA_Human1.71077956
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69856727
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69558403
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68956987
46* SPI1_23547873_ChIP-Seq_NB4_Human1.67201782
47TCF7_22412390_ChIP-Seq_EML_Mouse1.66686282
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.64901744
49DCP1A_22483619_ChIP-Seq_HELA_Human1.64899027
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64469910
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62038046
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60829338
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59925191
54VDR_21846776_ChIP-Seq_THP-1_Human1.57667621
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57635372
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56422078
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56317559
58KDM2B_26808549_Chip-Seq_DND41_Human1.55395546
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.54465386
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54115124
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53620145
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53509069
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.53247027
64ATF3_27146783_Chip-Seq_COLON_Human1.51963509
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51614787
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50231690
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49725768
68GABP_19822575_ChIP-Seq_HepG2_Human1.49505778
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46779395
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.46344470
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46109162
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45215285
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43623743
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40987510
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40736961
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40683877
77MYC_22102868_ChIP-Seq_BL_Human1.38094887
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37633559
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37616209
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36765205
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35932554
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.35848227
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.35417341
84TTF2_22483619_ChIP-Seq_HELA_Human1.35232335
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33974150
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33690012
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33522289
88KDM2B_26808549_Chip-Seq_K562_Human1.33385670
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32024853
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.31057785
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30242529
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30173157
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29554887
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.29107358
95CLOCK_20551151_ChIP-Seq_293T_Human1.28603528
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.28347766
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27963405
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27927232
99MYB_26560356_Chip-Seq_TH1_Human1.27757290
100KDM5A_27292631_Chip-Seq_BREAST_Human1.27747588
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27148365
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26983123
103NCOR1_26117541_ChIP-Seq_K562_Human1.26652467
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26364123
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26281085
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26185733
107* P68_20966046_ChIP-Seq_HELA_Human1.26022953
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23799990
109MYB_26560356_Chip-Seq_TH2_Human1.23231593
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23218885
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22432365
112SCL_19346495_ChIP-Seq_HPC-7_Human1.22043888
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21493643
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20168865
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18537134
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18273211
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17845003
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17279936
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16816604
120SA1_27219007_Chip-Seq_ERYTHROID_Human1.16563353
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16358569
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14298921
123TFEB_21752829_ChIP-Seq_HELA_Human1.13641585
124MAF_26560356_Chip-Seq_TH1_Human1.13324849
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13185914
126AR_21909140_ChIP-Seq_LNCAP_Human1.13183758
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10509496
128NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10468397
129TP53_22127205_ChIP-Seq_IMR90_Human1.09212640
130CREB1_26743006_Chip-Seq_LNCaP_Human1.09109195
131ELK1_22589737_ChIP-Seq_MCF10A_Human1.08451007
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08433762
133KDM2B_26808549_Chip-Seq_JURKAT_Human1.08327018
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07993296
135UTX_26944678_Chip-Seq_JUKART_Human1.07908829
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06866588
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06558473
138UBF1/2_26484160_Chip-Seq_HMECs_Human1.06314561
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05856260
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05670565
141HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05445365
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05120261
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04707793
144GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04609449
145SMC4_20622854_ChIP-Seq_HELA_Human1.04329479
146MAF_26560356_Chip-Seq_TH2_Human1.03151892
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03019026
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02952364
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02835117
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02542536
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02539496
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02193051
153VDR_24763502_ChIP-Seq_THP-1_Human1.01868101
154BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01580399
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01359967
156LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00807332
157ELF1_20517297_ChIP-Seq_JURKAT_Human1.00789300
158PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00122646
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99575495
160ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99227142
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98723587
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.98682139
163TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98541335
164TP63_19390658_ChIP-ChIP_HaCaT_Human0.98324994
165RUNX1_22412390_ChIP-Seq_EML_Mouse0.98053050
166THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96352346
167IRF8_27001747_Chip-Seq_BMDM_Mouse0.95854469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.43229270
2MP0005451_abnormal_body_composition3.70076943
3MP0010234_abnormal_vibrissa_follicle3.54993605
4MP0003693_abnormal_embryo_hatching2.86737747
5MP0005076_abnormal_cell_differentiation2.79507251
6MP0002877_abnormal_melanocyte_morpholog2.73758273
7MP0004185_abnormal_adipocyte_glucose2.57706669
8MP0001835_abnormal_antigen_presentation2.33711390
9MP0008057_abnormal_DNA_replication2.27019873
10MP0003453_abnormal_keratinocyte_physiol2.23169269
11MP0009840_abnormal_foam_cell2.22262137
12MP0002396_abnormal_hematopoietic_system2.15191352
13MP0003566_abnormal_cell_adhesion2.11103112
14MP0001849_ear_inflammation2.06255520
15MP0002693_abnormal_pancreas_physiology2.02897078
16MP0004858_abnormal_nervous_system1.93545171
17MP0008438_abnormal_cutaneous_collagen1.91096619
18MP0002796_impaired_skin_barrier1.88280199
19MP0003300_gastrointestinal_ulcer1.85586391
20MP0002138_abnormal_hepatobiliary_system1.84815841
21MP0000537_abnormal_urethra_morphology1.83298536
22MP0005220_abnormal_exocrine_pancreas1.83200096
23MP0004233_abnormal_muscle_weight1.81517763
24MP0003191_abnormal_cellular_cholesterol1.77793861
25MP0003436_decreased_susceptibility_to1.74926618
26MP0008260_abnormal_autophagy1.74691647
27MP0005670_abnormal_white_adipose1.74584277
28MP0003763_abnormal_thymus_physiology1.72905467
29MP0005501_abnormal_skin_physiology1.71119536
30MP0003111_abnormal_nucleus_morphology1.68443963
31MP0008007_abnormal_cellular_replicative1.65959385
32MP0001986_abnormal_taste_sensitivity1.57006207
33MP0005058_abnormal_lysosome_morphology1.55761858
34MP0001790_abnormal_immune_system1.52965827
35MP0005387_immune_system_phenotype1.52965827
36MP0002060_abnormal_skin_morphology1.51320271
37MP0004947_skin_inflammation1.51214807
38MP0001944_abnormal_pancreas_morphology1.50707129
39* MP0005000_abnormal_immune_tolerance1.50543228
40MP0001800_abnormal_humoral_immune1.48047029
41MP0005174_abnormal_tail_pigmentation1.47264366
42MP0003172_abnormal_lysosome_physiology1.46791516
43MP0005671_abnormal_response_to1.46680927
44MP0009278_abnormal_bone_marrow1.46029609
45MP0008058_abnormal_DNA_repair1.45150554
46MP0003091_abnormal_cell_migration1.44987310
47MP0005075_abnormal_melanosome_morpholog1.43548792
48MP0005025_abnormal_response_to1.43426354
49MP0003195_calcinosis1.42691262
50MP0000613_abnormal_salivary_gland1.41101551
51MP0004043_abnormal_pH_regulation1.40360792
52MP0009643_abnormal_urine_homeostasis1.39347424
53MP0000685_abnormal_immune_system1.39285034
54MP0000733_abnormal_muscle_development1.38875208
55MP0001730_embryonic_growth_arrest1.37694909
56MP0003077_abnormal_cell_cycle1.37551148
57MP0005464_abnormal_platelet_physiology1.36909562
58MP0004957_abnormal_blastocyst_morpholog1.36446968
59MP0005257_abnormal_intraocular_pressure1.34332828
60MP0009333_abnormal_splenocyte_physiolog1.33997949
61MP0002723_abnormal_immune_serum1.33941748
62* MP0002419_abnormal_innate_immunity1.32068553
63MP0000490_abnormal_crypts_of1.31557522
64MP0001666_abnormal_nutrient_absorption1.30608803
65* MP0002452_abnormal_antigen_presenting1.30427826
66MP0002166_altered_tumor_susceptibility1.29219967
67MP0005023_abnormal_wound_healing1.27542083
68* MP0002420_abnormal_adaptive_immunity1.27324657
69MP0005623_abnormal_meninges_morphology1.26263478
70MP0003186_abnormal_redox_activity1.26157024
71MP0001216_abnormal_epidermal_layer1.26028271
72* MP0001819_abnormal_immune_cell1.24721025
73MP0008469_abnormal_protein_level1.23618126
74MP0000689_abnormal_spleen_morphology1.22962175
75MP0005365_abnormal_bile_salt1.22955723
76MP0002148_abnormal_hypersensitivity_rea1.22180827
77MP0001348_abnormal_lacrimal_gland1.21297916
78MP0009785_altered_susceptibility_to1.21214393
79MP0005375_adipose_tissue_phenotype1.21204532
80MP0003868_abnormal_feces_composition1.20395125
81MP0000003_abnormal_adipose_tissue1.19066420
82MP0010155_abnormal_intestine_physiology1.18928119
83MP0002398_abnormal_bone_marrow1.18729873
84MP0000350_abnormal_cell_proliferation1.17714357
85MP0003724_increased_susceptibility_to1.17429915
86MP0005379_endocrine/exocrine_gland_phen1.16786392
87MP0000858_altered_metastatic_potential1.16048330
88MP0002876_abnormal_thyroid_physiology1.14953700
89MP0002722_abnormal_immune_system1.14337036
90MP0000566_synostosis1.13268482
91MP0000716_abnormal_immune_system1.12476898
92* MP0001845_abnormal_inflammatory_respons1.12311668
93MP0003866_abnormal_defecation1.12002552
94MP0002139_abnormal_hepatobiliary_system1.11031410
95MP0000678_abnormal_parathyroid_gland1.09859614
96MP0002249_abnormal_larynx_morphology1.08572497
97MP0005409_darkened_coat_color1.08078211
98MP0004381_abnormal_hair_follicle1.07307713
99MP0000371_diluted_coat_color1.06026804
100MP0000703_abnormal_thymus_morphology1.05369043
101MP0009053_abnormal_anal_canal1.04909213
102MP0000467_abnormal_esophagus_morphology1.04745757
103MP0010307_abnormal_tumor_latency1.04635500
104MP0003786_premature_aging1.03421585
105MP0010352_gastrointestinal_tract_polyps1.02971936
106MP0002277_abnormal_respiratory_mucosa1.02746747
107MP0002429_abnormal_blood_cell1.01395442
108MP0004808_abnormal_hematopoietic_stem1.00741321
109MP0002006_tumorigenesis0.99852873
110MP0004264_abnormal_extraembryonic_tissu0.99852075
111MP0010094_abnormal_chromosome_stability0.99751568
112MP0004510_myositis0.99050672
113MP0002080_prenatal_lethality0.98466804
114* MP0005621_abnormal_cell_physiology0.97491663
115MP0004272_abnormal_basement_membrane0.96478779
116MP0002098_abnormal_vibrissa_morphology0.94762876
117MP0001186_pigmentation_phenotype0.94546579
118MP0006036_abnormal_mitochondrial_physio0.94539577
119MP0003567_abnormal_fetal_cardiomyocyte0.93512800
120MP0002405_respiratory_system_inflammati0.93207564
121MP0002089_abnormal_postnatal_growth/wei0.93189170
122MP0009931_abnormal_skin_appearance0.92150530
123MP0003303_peritoneal_inflammation0.92036151
124MP0001661_extended_life_span0.91900586
125MP0002019_abnormal_tumor_incidence0.91420583
126MP0005408_hypopigmentation0.90536799
127MP0002086_abnormal_extraembryonic_tissu0.90500934
128MP0001764_abnormal_homeostasis0.90338820
129MP0003123_paternal_imprinting0.89241250
130MP0005389_reproductive_system_phenotype0.89191170
131MP0009379_abnormal_foot_pigmentation0.88805569
132MP0008932_abnormal_embryonic_tissue0.88453263
133MP0000465_gastrointestinal_hemorrhage0.87368898
134MP0002078_abnormal_glucose_homeostasis0.87069058
135MP0005332_abnormal_amino_acid0.86942789
136MP0001873_stomach_inflammation0.86711133
137MP0005310_abnormal_salivary_gland0.86689651
138MP0004782_abnormal_surfactant_physiolog0.86617840
139MP0002160_abnormal_reproductive_system0.85591504
140MP0002909_abnormal_adrenal_gland0.85320742
141MP0000609_abnormal_liver_physiology0.84364933
142MP0003828_pulmonary_edema0.84214678
143MP0000313_abnormal_cell_death0.84145092
144MP0003984_embryonic_growth_retardation0.83879408
145MP0003806_abnormal_nucleotide_metabolis0.83322159
146MP0006292_abnormal_olfactory_placode0.83283277
147MP0000015_abnormal_ear_pigmentation0.83261655
148MP0001672_abnormal_embryogenesis/_devel0.82576202
149MP0005380_embryogenesis_phenotype0.82576202
150MP0002998_abnormal_bone_remodeling0.82475723
151MP0009764_decreased_sensitivity_to0.81752272
152MP0000747_muscle_weakness0.81135365
153MP0003448_altered_tumor_morphology0.79280306
154MP0005666_abnormal_adipose_tissue0.78451697
155MP0005319_abnormal_enzyme/_coenzyme0.77633671
156MP0010771_integument_phenotype0.76581962
157MP0001756_abnormal_urination0.76229457
158MP0002088_abnormal_embryonic_growth/wei0.76119178
159MP0001919_abnormal_reproductive_system0.76032937
160MP0000759_abnormal_skeletal_muscle0.75537342
161MP0009672_abnormal_birth_weight0.75247534
162MP0000681_abnormal_thyroid_gland0.74322563
163MP0001697_abnormal_embryo_size0.73617004
164MP0000343_altered_response_to0.72819445
165MP0002896_abnormal_bone_mineralization0.71955818
166MP0002970_abnormal_white_adipose0.71495086
167* MP0005384_cellular_phenotype0.71235164
168MP0003075_altered_response_to0.70876028
169MP0010030_abnormal_orbit_morphology0.69654475
170MP0000627_abnormal_mammary_gland0.69508561
171MP0000750_abnormal_muscle_regeneration0.68099015
172MP0001881_abnormal_mammary_gland0.67978605
173MP0000762_abnormal_tongue_morphology0.67316015
174MP0000477_abnormal_intestine_morphology0.65737536
175MP0001915_intracranial_hemorrhage0.65697865
176MP0000579_abnormal_nail_morphology0.65678362

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)4.15104115
2Hyperacusis (HP:0010780)3.69792650
3Proximal tubulopathy (HP:0000114)3.56567938
4Progressive muscle weakness (HP:0003323)3.42271838
5Hypoglycemic coma (HP:0001325)3.37868058
6Vertebral compression fractures (HP:0002953)3.35360826
7Type I transferrin isoform profile (HP:0003642)3.29656120
8Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.28846012
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.28776447
10Achilles tendon contracture (HP:0001771)3.27729427
11Granulocytopenia (HP:0001913)3.23886501
12Distal lower limb amyotrophy (HP:0008944)3.13472240
13Broad face (HP:0000283)3.13077684
14IgM deficiency (HP:0002850)3.11618724
15Hyperinsulinemic hypoglycemia (HP:0000825)3.10570882
16Generalized aminoaciduria (HP:0002909)3.06172117
17Abnormality of T cell physiology (HP:0011840)2.98237788
18Abnormality of the Achilles tendon (HP:0005109)2.93441770
19Premature rupture of membranes (HP:0001788)2.90999954
20Reticulocytopenia (HP:0001896)2.89481362
21Aplastic anemia (HP:0001915)2.86698774
22Reduced antithrombin III activity (HP:0001976)2.85772599
23Ulnar bowing (HP:0003031)2.82340607
24Vacuolated lymphocytes (HP:0001922)2.78860627
25Abnormal number of erythroid precursors (HP:0012131)2.78297225
26Protrusio acetabuli (HP:0003179)2.77623462
27Abnormal protein glycosylation (HP:0012346)2.71577436
28Abnormal glycosylation (HP:0012345)2.71577436
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71577436
30Abnormal protein N-linked glycosylation (HP:0012347)2.71577436
31Short nail (HP:0001799)2.67860018
32Abnormality of cells of the erythroid lineage (HP:0012130)2.66081306
33Increased connective tissue (HP:0009025)2.64738619
34Thrombocytosis (HP:0001894)2.64347877
35Hypoglycemic seizures (HP:0002173)2.63286341
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62281809
37Testicular atrophy (HP:0000029)2.62084251
38Abnormality of the distal phalanges of the toes (HP:0010182)2.62080241
39Abnormality of the common coagulation pathway (HP:0010990)2.46607883
40Upper limb amyotrophy (HP:0009129)2.43108339
41Distal upper limb amyotrophy (HP:0007149)2.43108339
42Trismus (HP:0000211)2.43036930
43Asymmetry of the thorax (HP:0001555)2.39581585
44Fragile skin (HP:0001030)2.38674759
45Late onset (HP:0003584)2.36487979
46Macrocytic anemia (HP:0001972)2.36361885
47Breast hypoplasia (HP:0003187)2.34407217
48Hepatic necrosis (HP:0002605)2.33244823
49Thin bony cortex (HP:0002753)2.32589625
50Flat acetabular roof (HP:0003180)2.32491284
51Symptomatic seizures (HP:0011145)2.29249915
52Distal lower limb muscle weakness (HP:0009053)2.28589872
53Eosinophilia (HP:0001880)2.27123302
54Abnormality of the intrinsic pathway (HP:0010989)2.26885195
55J-shaped sella turcica (HP:0002680)2.26849476
56Increased cerebral lipofuscin (HP:0011813)2.26810680
57Glucose intolerance (HP:0000833)2.20737029
58Cerebral aneurysm (HP:0004944)2.20512939
59Abnormality of small intestinal villus morphology (HP:0011472)2.19794125
60Villous atrophy (HP:0011473)2.19794125
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.18788112
62Osteolytic defects of the hand bones (HP:0009699)2.18788112
63Inflammation of the large intestine (HP:0002037)2.18406902
64Unilateral renal agenesis (HP:0000122)2.17943490
65Long palpebral fissure (HP:0000637)2.16592659
66Abnormality of T cells (HP:0002843)2.15984908
67Disproportionate tall stature (HP:0001519)2.14859015
68Selective tooth agenesis (HP:0001592)2.13723644
6911 pairs of ribs (HP:0000878)2.11625452
70Hyperparathyroidism (HP:0000843)2.11424203
71Chromsome breakage (HP:0040012)2.11082526
72Axonal loss (HP:0003447)2.10112128
73Cervical subluxation (HP:0003308)2.07616115
74Recurrent abscess formation (HP:0002722)2.07470490
75Birth length less than 3rd percentile (HP:0003561)2.07209778
76Insomnia (HP:0100785)2.07090631
77Petechiae (HP:0000967)2.07009654
78Elbow flexion contracture (HP:0002987)2.05374229
79Hyperglycemia (HP:0003074)2.04613924
80Gastrointestinal inflammation (HP:0004386)2.02825335
81Micronodular cirrhosis (HP:0001413)2.02486058
82Patellar dislocation (HP:0002999)2.02456672
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.01343451
84Dysostosis multiplex (HP:0000943)2.01051564
85Abnormality of macrophages (HP:0004311)2.01011524
86Abnormality of the umbilical cord (HP:0010881)2.00674496
87Prolonged bleeding time (HP:0003010)1.99700061
88Large for gestational age (HP:0001520)1.98698538
89Broad distal phalanx of finger (HP:0009836)1.98622280
90Insulin-resistant diabetes mellitus (HP:0000831)1.98459170
91Hemorrhage of the eye (HP:0011885)1.96544946
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95004886
93Generalized amyotrophy (HP:0003700)1.94914836
94Exertional dyspnea (HP:0002875)1.94334331
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.93680413
96Abnormality of the thoracic spine (HP:0100711)1.93580879
97Eczematoid dermatitis (HP:0000976)1.93489609
98Ragged-red muscle fibers (HP:0003200)1.93226491
99Meningitis (HP:0001287)1.92445858
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.91533689
101Lower limb amyotrophy (HP:0007210)1.91063493
102Abnormality of oral frenula (HP:0000190)1.90404065
103Mitral regurgitation (HP:0001653)1.90387511
104Stridor (HP:0010307)1.89969422
105Premature skin wrinkling (HP:0100678)1.89624808
106Ankyloglossia (HP:0010296)1.88419978
107Spinal cord compression (HP:0002176)1.87756910
108Stomach cancer (HP:0012126)1.87756397
109Syringomyelia (HP:0003396)1.87222577
110Spinal cord lesions (HP:0100561)1.87222577
111Microretrognathia (HP:0000308)1.86825667
112Mildly elevated creatine phosphokinase (HP:0008180)1.86604487
113Hypertensive crisis (HP:0100735)1.86133859
114Nuclear cataract (HP:0100018)1.84247792
115Hypokinesia (HP:0002375)1.83539395
116Difficulty climbing stairs (HP:0003551)1.82946711
117Aplasia/hypoplasia of the uterus (HP:0008684)1.82854682
118Decreased circulating renin level (HP:0003351)1.82470128
119Recurrent bacterial skin infections (HP:0005406)1.82427359
120Spinal rigidity (HP:0003306)1.81387633
121Microvesicular hepatic steatosis (HP:0001414)1.80880879
122Pallor (HP:0000980)1.80708071
123Septate vagina (HP:0001153)1.79858609
124Bone pain (HP:0002653)1.79522372
125Pancytopenia (HP:0001876)1.78913669
126Advanced eruption of teeth (HP:0006288)1.78635798
127Reticulocytosis (HP:0001923)1.78615194
128Myositis (HP:0100614)1.78608935
129Sparse lateral eyebrow (HP:0005338)1.78453884
130Colitis (HP:0002583)1.77961193
131Myocardial infarction (HP:0001658)1.77958643
132Abnormality of the renal collecting system (HP:0004742)1.77783546
133Periodontitis (HP:0000704)1.77637453
134Multiple enchondromatosis (HP:0005701)1.77019005
135Reduced subcutaneous adipose tissue (HP:0003758)1.76989152
136Carpal bone hypoplasia (HP:0001498)1.76917803
137Chronic obstructive pulmonary disease (HP:0006510)1.75574322
138Obstructive lung disease (HP:0006536)1.75574322
139Abnormal ossification of hand bones (HP:0005921)1.75352764
140Conjugated hyperbilirubinemia (HP:0002908)1.75348413
141Blue sclerae (HP:0000592)1.75180487
142Recurrent viral infections (HP:0004429)1.74961634
143Rough bone trabeculation (HP:0100670)1.74936469
144Abnormality of the tricuspid valve (HP:0001702)1.74898668
145Cholecystitis (HP:0001082)1.74323796
146Abnormal gallbladder physiology (HP:0012438)1.74323796
147Natal tooth (HP:0000695)1.74244466
148Pustule (HP:0200039)1.73718274
149Prominent metopic ridge (HP:0005487)1.73331098
150Progressive neurologic deterioration (HP:0002344)1.73256467
151Elevated erythrocyte sedimentation rate (HP:0003565)1.73145703
152Duplicated collecting system (HP:0000081)1.72573333
153Subacute progressive viral hepatitis (HP:0006572)1.72414449
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72103621
155Insulin resistance (HP:0000855)1.71651932
156Joint hemorrhage (HP:0005261)1.71600856
157Encephalitis (HP:0002383)1.71570982
158Ankle contracture (HP:0006466)1.70638476
159Cheilitis (HP:0100825)1.70534495
160Deviation of the thumb (HP:0009603)1.70305944
161Abnormality of liposaccharide metabolism (HP:0010968)1.69999698
162Abnormality of glycosphingolipid metabolism (HP:0004343)1.69999698
163Abnormality of glycolipid metabolism (HP:0010969)1.69999698
164Back pain (HP:0003418)1.69954312
165Abnormality of carpal bone ossification (HP:0006257)1.69359864
166Ketoacidosis (HP:0001993)1.69286961
167IgA deficiency (HP:0002720)1.69084600
168Urinary glycosaminoglycan excretion (HP:0003541)1.68515181
169Mucopolysacchariduria (HP:0008155)1.68515181
170Interstitial pulmonary disease (HP:0006530)1.68331609
171Nausea (HP:0002018)1.68230587
172Bone marrow hypocellularity (HP:0005528)1.68092603
173Abnormality of fatty-acid metabolism (HP:0004359)1.67980867
174Abnormality of subcutaneous fat tissue (HP:0001001)1.67611070
175Agammaglobulinemia (HP:0004432)1.67581782
176Abdominal distention (HP:0003270)1.67498610
177Renal cortical cysts (HP:0000803)1.67223808
178Hepatocellular necrosis (HP:0001404)1.67112726
179Recurrent cutaneous fungal infections (HP:0011370)1.66766600
180Chronic mucocutaneous candidiasis (HP:0002728)1.66766600
181Ridged nail (HP:0001807)1.66363467
182Loss of speech (HP:0002371)1.65402422
183Bowed forearm bones (HP:0003956)1.63733102
184Bowing of the arm (HP:0006488)1.63733102
185Fatigue (HP:0012378)1.63251041
186Truncus arteriosus (HP:0001660)1.60352713
187Atrophic scars (HP:0001075)1.60311566
188Easy fatigability (HP:0003388)1.59884688
189Deep venous thrombosis (HP:0002625)1.59180495
190Multiple lipomas (HP:0001012)1.58398201
191Cerebral inclusion bodies (HP:0100314)1.57800496
192Cellulitis (HP:0100658)1.57444043
193Hyperthyroidism (HP:0000836)1.56978734
194Thoracic kyphosis (HP:0002942)1.56055574
195Congenital glaucoma (HP:0001087)1.56020349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.70524486
2PLK43.54015247
3ZAK3.44335991
4MST1R2.93746729
5EIF2AK32.79015593
6STK162.75026140
7TAOK32.72253311
8PRPF4B2.70097799
9ICK2.65962856
10EEF2K2.58323188
11BUB12.39626969
12ERN12.28825687
13MAP4K12.10323950
14INSRR2.03654943
15BCKDK2.02910077
16FLT31.98689745
17TTN1.96611600
18NME21.83640454
19PASK1.78442627
20CDK121.76873949
21TAOK21.69868700
22BLK1.69397206
23NLK1.67082467
24WEE11.61748204
25* IRAK41.57334674
26TEC1.55922898
27EPHA21.54978707
28SCYL21.52265069
29TYK21.50414402
30SRPK11.48802033
31TTK1.48521496
32JAK31.47224462
33BTK1.44979381
34ARAF1.44020458
35EIF2AK11.43456982
36MAP2K31.41717523
37BRSK21.38871639
38TESK11.38212204
39HIPK21.36783630
40PDGFRA1.35921454
41LMTK21.31762054
42RIPK11.30474657
43IKBKB1.27049397
44MET1.27016171
45ZAP701.20474465
46TAOK11.20098957
47DYRK31.20084924
48NEK91.19459557
49KIT1.17626972
50PTK21.16519587
51KDR1.15254977
52RPS6KA41.13729040
53MTOR1.09328216
54TESK21.09104168
55MAP3K141.08297979
56TSSK61.06241152
57TLK11.01236881
58PRKD30.99145118
59CDK80.97842476
60LRRK20.97698047
61PIK3CG0.97681839
62ILK0.97523664
63VRK10.97494817
64MAP3K130.95803137
65BRAF0.94455758
66RPS6KB20.92121857
67IKBKE0.92062975
68ATR0.91194111
69CHUK0.90977041
70CDC42BPA0.88884768
71CAMK1D0.88228358
72FRK0.87348148
73MAPK110.86899866
74JAK10.86219280
75KSR20.85709265
76PDPK10.84748087
77EPHA30.84380465
78STK100.84306030
79LATS20.84192662
80CDK40.82587803
81MAPK150.81867016
82BMX0.81852135
83MOS0.76816467
84PAK40.76547312
85TRIB30.75837961
86FGFR40.74150640
87MARK10.73444217
88PIM10.70802105
89MAPKAPK30.70736813
90TIE10.70734104
91TBK10.70273302
92EPHB10.70061119
93CLK10.70018844
94ABL20.69912442
95MAP2K20.69856484
96CSF1R0.69268393
97PIM20.68903066
98VRK20.68252675
99MAP3K30.67913339
100TGFBR20.65150054
101TXK0.64955903
102STK40.64331513
103MKNK20.64131183
104CSK0.63610794
105RPS6KA20.63336372
106DDR20.63286424
107PLK10.63239171
108PRKD20.63159570
109MAP3K110.62396672
110AURKB0.60853775
111SIK30.60136725
112ERBB40.59821971
113LCK0.58117885
114PKN20.58083046
115PRKG20.57881166
116AKT30.56829198
117STK38L0.56614794
118CDK70.56080558
119PTK60.56033075
120LYN0.55982641
121AURKA0.55038952
122NME10.54817215
123JAK20.54350189
124RPS6KC10.53853026
125RPS6KL10.53853026
126SYK0.53510831
127MAP3K80.53167267
128CHEK20.53010264
129MAP3K90.52808734
130* IRAK30.52690817
131PAK20.52374750
132STK240.52016671
133CDK60.52014708
134ITK0.51439611
135MARK20.51317451
136EIF2AK20.50615648
137MAP3K100.49899160
138BRD40.49749790
139NUAK10.48565637
140MAPKAPK20.47549372
141CDK90.46635436
142NTRK10.46267153
143TNK20.45796288
144CAMK1G0.45689309
145MAPK40.45372851
146SIK10.45288469
147MAPK70.44903053
148AKT20.42466146
149MELK0.42232789
150ATM0.42014669
151CSNK2A10.41920832
152MAP3K10.41309432
153MAP3K20.38395811
154DAPK10.36870096
155EPHB20.36696950
156LIMK10.36623949
157PAK10.36072739
158PBK0.36024451
159CHEK10.35927476
160BRSK10.35092604
161PDK10.34918430
162RPS6KA60.33145849

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.43707815
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.99687068
3Ribosome_Homo sapiens_hsa030103.42203640
4DNA replication_Homo sapiens_hsa030303.19752474
5RNA polymerase_Homo sapiens_hsa030202.45677622
6Bladder cancer_Homo sapiens_hsa052192.42445500
7Mismatch repair_Homo sapiens_hsa034302.35731513
8Chronic myeloid leukemia_Homo sapiens_hsa052202.35288619
9Other glycan degradation_Homo sapiens_hsa005112.30041457
10One carbon pool by folate_Homo sapiens_hsa006702.18546856
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15325779
12Central carbon metabolism in cancer_Homo sapiens_hsa052302.03071378
13Pyrimidine metabolism_Homo sapiens_hsa002401.98330129
14Proteasome_Homo sapiens_hsa030501.91237676
15Non-small cell lung cancer_Homo sapiens_hsa052231.89772984
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87642203
17Homologous recombination_Homo sapiens_hsa034401.83557050
18Pancreatic cancer_Homo sapiens_hsa052121.80652977
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72175456
20Fanconi anemia pathway_Homo sapiens_hsa034601.71790613
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64287284
22Spliceosome_Homo sapiens_hsa030401.62701924
23Base excision repair_Homo sapiens_hsa034101.60210385
24VEGF signaling pathway_Homo sapiens_hsa043701.56446521
25Folate biosynthesis_Homo sapiens_hsa007901.53152263
26Notch signaling pathway_Homo sapiens_hsa043301.51106382
27Nucleotide excision repair_Homo sapiens_hsa034201.51088790
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49866247
29Prion diseases_Homo sapiens_hsa050201.44806774
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44470612
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42248741
32Biosynthesis of amino acids_Homo sapiens_hsa012301.41154101
33Antigen processing and presentation_Homo sapiens_hsa046121.39729294
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37862622
35Renal cell carcinoma_Homo sapiens_hsa052111.35978028
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.33823005
37Primary immunodeficiency_Homo sapiens_hsa053401.28825583
38Endometrial cancer_Homo sapiens_hsa052131.27640986
39N-Glycan biosynthesis_Homo sapiens_hsa005101.27336769
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25547417
41p53 signaling pathway_Homo sapiens_hsa041151.22804175
42* NF-kappa B signaling pathway_Homo sapiens_hsa040641.21392537
43Glioma_Homo sapiens_hsa052141.20327631
44Shigellosis_Homo sapiens_hsa051311.20150660
45RNA transport_Homo sapiens_hsa030131.16502893
46mTOR signaling pathway_Homo sapiens_hsa041501.15332929
47Selenocompound metabolism_Homo sapiens_hsa004501.15013818
48Hepatitis B_Homo sapiens_hsa051611.13652433
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13261059
50Vitamin B6 metabolism_Homo sapiens_hsa007501.11340987
51Insulin signaling pathway_Homo sapiens_hsa049101.10540890
52RNA degradation_Homo sapiens_hsa030181.09701700
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08516329
54Salmonella infection_Homo sapiens_hsa051321.06393975
55TNF signaling pathway_Homo sapiens_hsa046681.06084624
56Proteoglycans in cancer_Homo sapiens_hsa052051.05359526
57ErbB signaling pathway_Homo sapiens_hsa040121.00870121
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.00612385
59Non-homologous end-joining_Homo sapiens_hsa034501.00301500
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00071700
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99680856
62Vibrio cholerae infection_Homo sapiens_hsa051100.98811971
63MicroRNAs in cancer_Homo sapiens_hsa052060.98052021
64* Neurotrophin signaling pathway_Homo sapiens_hsa047220.96142650
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96043096
66Focal adhesion_Homo sapiens_hsa045100.95159251
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92971508
68Herpes simplex infection_Homo sapiens_hsa051680.92294281
69Purine metabolism_Homo sapiens_hsa002300.90682812
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89948382
71Arachidonic acid metabolism_Homo sapiens_hsa005900.89404831
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88085609
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87859829
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87260281
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86970392
76Carbon metabolism_Homo sapiens_hsa012000.86638795
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85897771
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.84830888
79* Epstein-Barr virus infection_Homo sapiens_hsa051690.84810014
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83797212
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.83624438
82Sulfur metabolism_Homo sapiens_hsa009200.83362757
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83344641
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.83137815
85Glutathione metabolism_Homo sapiens_hsa004800.82976331
86Lysosome_Homo sapiens_hsa041420.82962901
87AMPK signaling pathway_Homo sapiens_hsa041520.82938726
88Acute myeloid leukemia_Homo sapiens_hsa052210.82518891
89* Measles_Homo sapiens_hsa051620.81655887
90Galactose metabolism_Homo sapiens_hsa000520.80333876
91Cell cycle_Homo sapiens_hsa041100.77132470
92Pentose phosphate pathway_Homo sapiens_hsa000300.77074867
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76359419
94Amoebiasis_Homo sapiens_hsa051460.75831728
95Hematopoietic cell lineage_Homo sapiens_hsa046400.73868971
96Insulin resistance_Homo sapiens_hsa049310.73585237
97Prolactin signaling pathway_Homo sapiens_hsa049170.73381456
98HIF-1 signaling pathway_Homo sapiens_hsa040660.72969388
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72480492
100Colorectal cancer_Homo sapiens_hsa052100.72415154
101Basal transcription factors_Homo sapiens_hsa030220.69711262
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69163694
103Sulfur relay system_Homo sapiens_hsa041220.68806015
104Tryptophan metabolism_Homo sapiens_hsa003800.68786568
105* Toxoplasmosis_Homo sapiens_hsa051450.67895702
106Starch and sucrose metabolism_Homo sapiens_hsa005000.67589622
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67497419
108beta-Alanine metabolism_Homo sapiens_hsa004100.67062214
109Melanoma_Homo sapiens_hsa052180.66892155
110Endocytosis_Homo sapiens_hsa041440.66854085
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.66376930
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66074067
113* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65087279
114* Leishmaniasis_Homo sapiens_hsa051400.64466627
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.62652847
116Fatty acid biosynthesis_Homo sapiens_hsa000610.62486900
117Peroxisome_Homo sapiens_hsa041460.62365565
118Phenylalanine metabolism_Homo sapiens_hsa003600.60049304
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59993271
120Estrogen signaling pathway_Homo sapiens_hsa049150.58996874
121B cell receptor signaling pathway_Homo sapiens_hsa046620.58740508
122ABC transporters_Homo sapiens_hsa020100.58119712
123Legionellosis_Homo sapiens_hsa051340.57553171
124Lysine degradation_Homo sapiens_hsa003100.56983147
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.56974786
126GnRH signaling pathway_Homo sapiens_hsa049120.56949915
127Fatty acid degradation_Homo sapiens_hsa000710.56559538
128Oxidative phosphorylation_Homo sapiens_hsa001900.56521308
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55937554
130Parkinsons disease_Homo sapiens_hsa050120.55063116
131Osteoclast differentiation_Homo sapiens_hsa043800.54995633
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54356889
133Adherens junction_Homo sapiens_hsa045200.53384326
134Thyroid cancer_Homo sapiens_hsa052160.52832167
135Sphingolipid metabolism_Homo sapiens_hsa006000.51376225
136Staphylococcus aureus infection_Homo sapiens_hsa051500.50993964
137Inositol phosphate metabolism_Homo sapiens_hsa005620.50671319
138Apoptosis_Homo sapiens_hsa042100.50447286
139Metabolic pathways_Homo sapiens_hsa011000.49546572
140Fat digestion and absorption_Homo sapiens_hsa049750.49043882
141mRNA surveillance pathway_Homo sapiens_hsa030150.48547035
142Influenza A_Homo sapiens_hsa051640.48064750
143Choline metabolism in cancer_Homo sapiens_hsa052310.47993788
144Histidine metabolism_Homo sapiens_hsa003400.47110365
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.46713154
146Regulation of autophagy_Homo sapiens_hsa041400.45187206
147Fructose and mannose metabolism_Homo sapiens_hsa000510.43759200
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43702599
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42875935
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42078249
151Huntingtons disease_Homo sapiens_hsa050160.40932661
152Tyrosine metabolism_Homo sapiens_hsa003500.39553938
153HTLV-I infection_Homo sapiens_hsa051660.39277763
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37948700
155Prostate cancer_Homo sapiens_hsa052150.36990051
156* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36168157
157Small cell lung cancer_Homo sapiens_hsa052220.36047540
158Viral carcinogenesis_Homo sapiens_hsa052030.35496803
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35474993
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35259978
161SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34936823
162Hepatitis C_Homo sapiens_hsa051600.34223201
163Arginine and proline metabolism_Homo sapiens_hsa003300.32251546

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