IRAK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.50711214
2regulation of vitamin metabolic process (GO:0030656)5.25302079
3positive regulation by symbiont of host defense response (GO:0052509)5.20827455
4modulation by symbiont of host defense response (GO:0052031)5.20827455
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.20827455
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.20827455
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.20827455
8modulation by symbiont of host immune response (GO:0052553)5.20827455
9response to peptidoglycan (GO:0032494)4.45157255
10response to muramyl dipeptide (GO:0032495)4.30964341
11regulation of chronic inflammatory response (GO:0002676)4.24583351
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18663092
13regulation of podosome assembly (GO:0071801)4.13827515
14positive regulation of interferon-alpha production (GO:0032727)4.06826246
15regulation of cytokine secretion involved in immune response (GO:0002739)4.06327949
16macrophage activation involved in immune response (GO:0002281)4.04984753
17neutrophil activation involved in immune response (GO:0002283)4.04096578
18regulation of interferon-beta biosynthetic process (GO:0045357)3.93728470
19positive regulation of gamma-delta T cell activation (GO:0046645)3.93044958
20positive regulation of heat generation (GO:0031652)3.91447223
21regulation of interferon-alpha production (GO:0032647)3.89569527
22regulation of mononuclear cell migration (GO:0071675)3.86624479
23regulation of T-helper 1 cell differentiation (GO:0045625)3.84000746
24positive regulation of cellular amide metabolic process (GO:0034250)3.80176500
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.75006915
26NIK/NF-kappaB signaling (GO:0038061)3.60288427
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42514203
28response to host immune response (GO:0052572)3.42514203
29antigen processing and presentation of endogenous antigen (GO:0019883)3.38681411
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.36659791
31negative regulation of cytokine production involved in immune response (GO:0002719)3.35755359
32positive regulation of chemokine biosynthetic process (GO:0045080)3.34927807
33positive regulation of nitric oxide biosynthetic process (GO:0045429)3.31619357
34monocyte chemotaxis (GO:0002548)3.31090913
35microglial cell activation (GO:0001774)3.30922362
36immunoglobulin mediated immune response (GO:0016064)3.28299312
37granulocyte activation (GO:0036230)3.28254909
38positive regulation of antigen processing and presentation (GO:0002579)3.28149888
39regulation of fever generation (GO:0031620)3.27774874
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27508692
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27508692
42* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23699507
43negative regulation of interleukin-12 production (GO:0032695)3.22732260
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22719706
45positive regulation of acute inflammatory response (GO:0002675)3.20890715
46positive regulation of type 2 immune response (GO:0002830)3.20812214
47neutrophil activation (GO:0042119)3.19077700
48regulation of nitric oxide biosynthetic process (GO:0045428)3.17633238
49response to protozoan (GO:0001562)3.17407525
50low-density lipoprotein particle clearance (GO:0034383)3.16647139
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15204777
52response to host (GO:0075136)3.14239156
53response to host defenses (GO:0052200)3.14239156
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14239156
55positive regulation of interferon-beta production (GO:0032728)3.11498963
56* cellular response to lipopolysaccharide (GO:0071222)3.11469845
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09105824
58respiratory burst (GO:0045730)3.08503029
59positive regulation of interleukin-6 production (GO:0032755)3.07946768
60positive regulation of interleukin-12 production (GO:0032735)3.07633448
61regulation of NF-kappaB import into nucleus (GO:0042345)3.07229742
62regulation of immunoglobulin secretion (GO:0051023)3.04436254
63negative regulation of nitric oxide biosynthetic process (GO:0045019)3.03312848
64detection of molecule of bacterial origin (GO:0032490)3.03193569
65* cellular response to molecule of bacterial origin (GO:0071219)3.03107853
66negative regulation of lipid storage (GO:0010888)3.02782779
67macrophage activation (GO:0042116)3.02072052
68regulation of B cell receptor signaling pathway (GO:0050855)2.99164769
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98738984
70regulation of T-helper 2 cell differentiation (GO:0045628)2.98630636
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96904416
72regulation of activation of Janus kinase activity (GO:0010533)2.96361659
73interferon-gamma-mediated signaling pathway (GO:0060333)2.94591251
74regulation of gamma-delta T cell activation (GO:0046643)2.94038125
75regulation of heat generation (GO:0031650)2.93163695
76cellular response to nicotine (GO:0071316)2.92788331
77hydrogen peroxide biosynthetic process (GO:0050665)2.90973392
78response to type I interferon (GO:0034340)2.90220033
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89453714
80cellular response to type I interferon (GO:0071357)2.89330946
81type I interferon signaling pathway (GO:0060337)2.89330946
82regulation of heterotypic cell-cell adhesion (GO:0034114)2.87213479
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86946039
84positive regulation of T-helper cell differentiation (GO:0045624)2.86850235
85positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84043697
86regulation of cholesterol storage (GO:0010885)2.83355682
87regulation of vascular endothelial growth factor production (GO:0010574)2.83171403
88germinal center formation (GO:0002467)2.83016296
89negative regulation of myeloid cell apoptotic process (GO:0033033)2.82134071
90cytokine secretion (GO:0050663)2.81816324
91regulation of antigen processing and presentation (GO:0002577)2.81753452
92cellular response to ethanol (GO:0071361)2.80869220
93superoxide anion generation (GO:0042554)2.80695456
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.80389993
95regulation of interleukin-12 production (GO:0032655)2.80086563
96myeloid cell activation involved in immune response (GO:0002275)2.79610058
97modulation of growth of symbiont involved in interaction with host (GO:0044144)2.79380350
98regulation of growth of symbiont in host (GO:0044126)2.79380350
99negative regulation of growth of symbiont in host (GO:0044130)2.79380350
100negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.79380350
101oligosaccharide catabolic process (GO:0009313)2.77956732
102regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77681931
103positive regulation of chemokine production (GO:0032722)2.76821230
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76346557
105leukocyte aggregation (GO:0070486)2.75839863
106regulation of prostaglandin secretion (GO:0032306)2.74703821
107I-kappaB phosphorylation (GO:0007252)2.74318724
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.73798753
109positive regulation of transcription factor import into nucleus (GO:0042993)2.72603604
110positive regulation of interleukin-17 production (GO:0032740)2.72364468
111T-helper 1 type immune response (GO:0042088)2.72286146
112tolerance induction (GO:0002507)2.70344842
113regulation of T-helper cell differentiation (GO:0045622)2.69548221
114regulation of interleukin-6 production (GO:0032675)2.69278033
115regulation of chemokine biosynthetic process (GO:0045073)2.66696665
116myeloid dendritic cell differentiation (GO:0043011)2.66659183
117positive regulation of NF-kappaB import into nucleus (GO:0042346)2.66243739
118negative regulation of production of molecular mediator of immune response (GO:0002701)2.64432634
119cellular response to arsenic-containing substance (GO:0071243)2.64389250
120* cellular response to biotic stimulus (GO:0071216)2.63595956
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.62024147
122JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61026662
123positive regulation of B cell differentiation (GO:0045579)2.60396285
124positive regulation vascular endothelial growth factor production (GO:0010575)2.60335465
125cellular extravasation (GO:0045123)2.60130611
126detection of other organism (GO:0098543)2.59381108
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.59295794
128positive regulation of humoral immune response (GO:0002922)2.58903865
129eosinophil chemotaxis (GO:0048245)2.58801074
130regulation of lymphocyte chemotaxis (GO:1901623)2.58600531
131glycosphingolipid catabolic process (GO:0046479)2.57531401
132positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57226488
133mature B cell differentiation (GO:0002335)2.57067823
134natural killer cell mediated immunity (GO:0002228)2.56953468
135natural killer cell mediated cytotoxicity (GO:0042267)2.56953468
136T cell migration (GO:0072678)2.56800613
137positive regulation of lipid storage (GO:0010884)2.56730969
138regulation of mast cell degranulation (GO:0043304)2.53807590
139regulation of gamma-delta T cell differentiation (GO:0045586)2.52870467
140defense response to protozoan (GO:0042832)2.52061245
141myeloid dendritic cell activation (GO:0001773)2.50252768
142reactive oxygen species biosynthetic process (GO:1903409)2.49610131
143detection of external biotic stimulus (GO:0098581)2.49300075
144regulation of interleukin-17 production (GO:0032660)2.48532277
145cellular response to virus (GO:0098586)2.45415602
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45216244
147regulation of interleukin-8 biosynthetic process (GO:0045414)2.43207090
148positive regulation of cytokine biosynthetic process (GO:0042108)2.43075724
149leukocyte cell-cell adhesion (GO:0007159)2.42808821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.69684428
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.12407258
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.27867564
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.77327791
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66506690
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50165947
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49087843
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41479539
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37471856
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.26559156
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16962719
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.16014463
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76793909
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68128911
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61099788
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58442462
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.52091654
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49256529
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.31656235
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26480715
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22235291
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.20601744
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13509235
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11751669
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11040400
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10538976
27* LXR_22158963_ChIP-Seq_LIVER_Mouse2.00011993
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99749465
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98292158
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97917138
31RUNX_20019798_ChIP-Seq_JUKART_Human1.95777653
32SCL_19346495_ChIP-Seq_HPC-7_Human1.91478709
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84839894
34GATA1_22025678_ChIP-Seq_K562_Human1.75987904
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74186985
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71189843
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66154281
38SPI1_23547873_ChIP-Seq_NB4_Human1.65498885
39VDR_24787735_ChIP-Seq_THP-1_Human1.63220860
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62931781
41MYB_26560356_Chip-Seq_TH2_Human1.60703996
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59136414
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58938018
44VDR_24763502_ChIP-Seq_THP-1_Human1.57908162
45MAF_26560356_Chip-Seq_TH1_Human1.57776818
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55544789
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.54625913
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.50217161
49MYB_26560356_Chip-Seq_TH1_Human1.50037204
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48927435
51PU_27001747_Chip-Seq_BMDM_Mouse1.48590574
52SPI1_23127762_ChIP-Seq_K562_Human1.45210019
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35555623
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34971173
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29273484
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.26963449
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26282850
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26222383
59VDR_21846776_ChIP-Seq_THP-1_Human1.25195075
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21545922
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19616340
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16987108
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14206826
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11858966
65* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09893517
66* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08207852
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08107750
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08068149
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.07790641
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07684397
71* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06862076
72* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06580677
73GATA3_27048872_Chip-Seq_THYMUS_Human1.05407576
74TFEB_21752829_ChIP-Seq_HELA_Human1.04820462
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04710046
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.03779870
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03450959
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.02235123
79UTX_26944678_Chip-Seq_JUKART_Human1.02153038
80* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02090017
81GATA2_19941826_ChIP-Seq_K562_Human1.01540360
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01200897
83TCF7_22412390_ChIP-Seq_EML_Mouse0.99870289
84CLOCK_20551151_ChIP-Seq_293T_Human0.99792617
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.98610430
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.98419676
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97238495
88* GATA3_26560356_Chip-Seq_TH2_Human0.97228476
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.97103079
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96847721
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95411555
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95411555
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94288801
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.92099921
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91884034
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91410793
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89885316
98* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88157904
99GATA1_19941826_ChIP-Seq_K562_Human0.87555265
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86536495
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85684134
102* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85289143
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84745777
104SOX2_20726797_ChIP-Seq_SW620_Human0.84624029
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84221205
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82335648
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82084427
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81784103
109STAT1_20625510_ChIP-Seq_HELA_Human0.81686015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.65758512
2MP0003436_decreased_susceptibility_to3.23513455
3MP0009785_altered_susceptibility_to3.14455398
4MP0003303_peritoneal_inflammation2.89398840
5MP0005387_immune_system_phenotype2.83299771
6MP0001790_abnormal_immune_system2.83299771
7* MP0002419_abnormal_innate_immunity2.73521979
8MP0005000_abnormal_immune_tolerance2.72947215
9MP0000685_abnormal_immune_system2.62770411
10MP0003724_increased_susceptibility_to2.61854882
11MP0002148_abnormal_hypersensitivity_rea2.59061025
12MP0006082_CNS_inflammation2.55694743
13MP0001800_abnormal_humoral_immune2.53959382
14MP0005025_abnormal_response_to2.48846288
15MP0005671_abnormal_response_to2.45478263
16* MP0002452_abnormal_antigen_presenting2.43546719
17MP0009840_abnormal_foam_cell2.34216146
18* MP0002723_abnormal_immune_serum2.30832907
19MP0004510_myositis2.18521693
20MP0005058_abnormal_lysosome_morphology2.17905058
21MP0004947_skin_inflammation2.10409740
22* MP0001819_abnormal_immune_cell2.00700233
23MP0008004_abnormal_stomach_pH1.99929188
24MP0001853_heart_inflammation1.99589891
25* MP0002420_abnormal_adaptive_immunity1.98494101
26MP0005464_abnormal_platelet_physiology1.96950710
27MP0002254_reproductive_system_inflammat1.93214384
28MP0003195_calcinosis1.91502589
29MP0002405_respiratory_system_inflammati1.86436878
30MP0003191_abnormal_cellular_cholesterol1.86182324
31MP0002332_abnormal_exercise_endurance1.84915774
32MP0010155_abnormal_intestine_physiology1.80851955
33* MP0009764_decreased_sensitivity_to1.80150340
34* MP0001845_abnormal_inflammatory_respons1.79220946
35MP0001533_abnormal_skeleton_physiology1.79081311
36MP0006054_spinal_hemorrhage1.69704356
37MP0003300_gastrointestinal_ulcer1.68300705
38* MP0008469_abnormal_protein_level1.67953473
39MP0005360_urolithiasis1.67744476
40MP0002138_abnormal_hepatobiliary_system1.66203565
41MP0009278_abnormal_bone_marrow1.66153988
42MP0000343_altered_response_to1.57143155
43MP0001873_stomach_inflammation1.52956995
44MP0003448_altered_tumor_morphology1.49295529
45MP0003172_abnormal_lysosome_physiology1.48945822
46MP0000716_abnormal_immune_system1.45905525
47MP0002139_abnormal_hepatobiliary_system1.44999064
48MP0005397_hematopoietic_system_phenotyp1.40698390
49MP0001545_abnormal_hematopoietic_system1.40698390
50MP0002006_tumorigenesis1.40631474
51MP0003075_altered_response_to1.38870175
52MP0002998_abnormal_bone_remodeling1.38202941
53MP0002398_abnormal_bone_marrow1.36507600
54MP0009333_abnormal_splenocyte_physiolog1.35996701
55MP0005167_abnormal_blood-brain_barrier1.29775894
56MP0000689_abnormal_spleen_morphology1.27370350
57MP0003806_abnormal_nucleotide_metabolis1.24237725
58MP0000604_amyloidosis1.24145944
59MP0000858_altered_metastatic_potential1.23840426
60MP0002166_altered_tumor_susceptibility1.23035427
61MP0003950_abnormal_plasma_membrane1.21913616
62MP0003183_abnormal_peptide_metabolism1.18748385
63MP0000609_abnormal_liver_physiology1.18017774
64MP0002429_abnormal_blood_cell1.16693246
65MP0000569_abnormal_digit_pigmentation1.16340065
66MP0004782_abnormal_surfactant_physiolog1.13189888
67MP0002722_abnormal_immune_system1.12482454
68MP0005166_decreased_susceptibility_to1.12347254
69MP0008260_abnormal_autophagy1.11628268
70MP0009763_increased_sensitivity_to1.10759639
71MP0003453_abnormal_keratinocyte_physiol1.09823738
72MP0005310_abnormal_salivary_gland1.08975006
73MP0003566_abnormal_cell_adhesion1.08543622
74MP0005365_abnormal_bile_salt1.06249655
75MP0010329_abnormal_lipoprotein_level1.03867466
76MP0003690_abnormal_glial_cell1.02391060
77MP0003828_pulmonary_edema1.00484912
78MP0003656_abnormal_erythrocyte_physiolo1.00378404
79MP0003763_abnormal_thymus_physiology1.00217521
80MP0002933_joint_inflammation0.99953659
81MP0002877_abnormal_melanocyte_morpholog0.99368003
82MP0003186_abnormal_redox_activity0.98251661
83MP0004019_abnormal_vitamin_homeostasis0.98180179
84MP0002136_abnormal_kidney_physiology0.96662773
85MP0005164_abnormal_response_to0.96162541
86MP0003646_muscle_fatigue0.95712698
87MP0005085_abnormal_gallbladder_physiolo0.95532729
88MP0003252_abnormal_bile_duct0.95349008
89MP0002277_abnormal_respiratory_mucosa0.94872963
90MP0000249_abnormal_blood_vessel0.94223400
91MP0005165_increased_susceptibility_to0.90682364
92MP0000465_gastrointestinal_hemorrhage0.86272390
93MP0005076_abnormal_cell_differentiation0.86147771
94MP0005670_abnormal_white_adipose0.85084360
95MP0001851_eye_inflammation0.83907055
96MP0003091_abnormal_cell_migration0.82954904
97MP0005319_abnormal_enzyme/_coenzyme0.82582539
98MP0005390_skeleton_phenotype0.82054155
99MP0003045_fibrosis0.81807180
100MP0001881_abnormal_mammary_gland0.79806254
101MP0005451_abnormal_body_composition0.79234419
102MP0000920_abnormal_myelination0.78771468
103MP0010352_gastrointestinal_tract_polyps0.77676594
104MP0003866_abnormal_defecation0.76428954
105MP0005083_abnormal_biliary_tract0.75746961
106MP0005023_abnormal_wound_healing0.74893830
107MP0008874_decreased_physiological_sensi0.73463236
108MP0001501_abnormal_sleep_pattern0.72940943
109MP0005535_abnormal_body_temperature0.71638507
110MP0009643_abnormal_urine_homeostasis0.71364350
111MP0001663_abnormal_digestive_system0.69521959
112MP0002118_abnormal_lipid_homeostasis0.68951937
113MP0009765_abnormal_xenobiotic_induced0.68145810
114MP0000371_diluted_coat_color0.67961303
115MP0004808_abnormal_hematopoietic_stem0.67559948
116MP0005647_abnormal_sex_gland0.61680345
117MP0003221_abnormal_cardiomyocyte_apopto0.61419104
118MP0003795_abnormal_bone_structure0.60982647
119MP0004883_abnormal_blood_vessel0.57707082
120MP0005266_abnormal_metabolism0.53881942

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.70832558
2Eczematoid dermatitis (HP:0000976)5.53167465
3Recurrent bacterial skin infections (HP:0005406)5.50990095
4Recurrent gram-negative bacterial infections (HP:0005420)4.79569489
5Orchitis (HP:0100796)4.75380739
6Retrobulbar optic neuritis (HP:0100654)4.70037977
7Optic neuritis (HP:0100653)4.70037977
8Myositis (HP:0100614)4.52245766
9Abnormality of macrophages (HP:0004311)4.35498930
10Stomatitis (HP:0010280)4.25431279
11Mediastinal lymphadenopathy (HP:0100721)4.09141166
12Autoimmune thrombocytopenia (HP:0001973)4.06817236
13Loss of speech (HP:0002371)3.90974625
14Elevated erythrocyte sedimentation rate (HP:0003565)3.86846331
15Systemic lupus erythematosus (HP:0002725)3.84232082
16Recurrent skin infections (HP:0001581)3.76342326
17Recurrent fungal infections (HP:0002841)3.69919663
18Myocardial infarction (HP:0001658)3.64895504
19Vasculitis (HP:0002633)3.46488897
20Vacuolated lymphocytes (HP:0001922)3.43497642
21Gingivitis (HP:0000230)3.28270254
22Pustule (HP:0200039)3.20440453
23Disinhibition (HP:0000734)3.18514755
24Gangrene (HP:0100758)3.16773314
25Recurrent viral infections (HP:0004429)3.15131147
26Pulmonary infiltrates (HP:0002113)3.12044933
27Keratoconjunctivitis sicca (HP:0001097)3.05706126
28Recurrent cutaneous fungal infections (HP:0011370)2.98561480
29Chronic mucocutaneous candidiasis (HP:0002728)2.98561480
30Arterial thrombosis (HP:0004420)2.97510544
31Neurofibrillary tangles (HP:0002185)2.96968168
32Colitis (HP:0002583)2.88893877
33Keratoconjunctivitis (HP:0001096)2.88194516
34Interstitial pulmonary disease (HP:0006530)2.85709503
35Increased cerebral lipofuscin (HP:0011813)2.82224436
36Mutism (HP:0002300)2.78595339
37Glomerulonephritis (HP:0000099)2.76841046
38Obstructive lung disease (HP:0006536)2.75047666
39Chronic obstructive pulmonary disease (HP:0006510)2.75047666
40Periodontitis (HP:0000704)2.74069521
41Tetraparesis (HP:0002273)2.72425649
42Urticaria (HP:0001025)2.70276980
43Gingival bleeding (HP:0000225)2.67167025
44Autoimmune hemolytic anemia (HP:0001890)2.66481779
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.61763653
46Axonal loss (HP:0003447)2.61274977
47Meningitis (HP:0001287)2.59920398
48Prostate neoplasm (HP:0100787)2.59831277
49Joint hemorrhage (HP:0005261)2.58979694
50Premature loss of primary teeth (HP:0006323)2.54361044
51Nuclear cataract (HP:0100018)2.52875408
52Cellulitis (HP:0100658)2.49880849
53Abnormality of iron homeostasis (HP:0011031)2.49432692
54Anorexia (HP:0002039)2.48363445
55Episodic fever (HP:0001954)2.48005654
56Purpura (HP:0000979)2.47483748
57Abnormality of proline metabolism (HP:0010907)2.44575800
58Hydroxyprolinuria (HP:0003080)2.44575800
59Apathy (HP:0000741)2.43001844
60Polyneuropathy (HP:0001271)2.42765140
61Inflammation of the large intestine (HP:0002037)2.42306527
62Parakeratosis (HP:0001036)2.40314579
63Hematochezia (HP:0002573)2.39985927
64Basal ganglia calcification (HP:0002135)2.38945346
65Thick nail (HP:0001805)2.38057854
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37960760
67Complement deficiency (HP:0004431)2.37827243
68Osteomyelitis (HP:0002754)2.36999438
69Diminished motivation (HP:0000745)2.35163878
70Amyloidosis (HP:0011034)2.35103008
71Leukocytosis (HP:0001974)2.31761812
72Hemoptysis (HP:0002105)2.31273331
73Gastrointestinal stroma tumor (HP:0100723)2.30835757
74Abnormality of liposaccharide metabolism (HP:0010968)2.30462228
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.30462228
76Abnormality of glycolipid metabolism (HP:0010969)2.30462228
77Increased IgE level (HP:0003212)2.29433464
78Chronic otitis media (HP:0000389)2.28046923
79Dysostosis multiplex (HP:0000943)2.27645847
80Encephalitis (HP:0002383)2.26706554
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25180050
82Gastrointestinal inflammation (HP:0004386)2.20824251
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.18322066
84IgM deficiency (HP:0002850)2.17924945
85Xanthomatosis (HP:0000991)2.17908126
86Progressive neurologic deterioration (HP:0002344)2.16161619
87Hepatosplenomegaly (HP:0001433)2.15481216
88Nephritis (HP:0000123)2.15263975
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14596787
90Abnormality of complement system (HP:0005339)2.14254229
91Esophageal varix (HP:0002040)2.13494428
92Cerebral inclusion bodies (HP:0100314)2.13022802
93Recurrent pneumonia (HP:0006532)2.12460534
94Abnormality of transition element cation homeostasis (HP:0011030)2.11924085
95Joint swelling (HP:0001386)2.10754862
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08888480
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.04079402
98Osteolytic defects of the hand bones (HP:0009699)2.04079402
99Gastrointestinal infarctions (HP:0005244)2.04043879
100Neuronal loss in central nervous system (HP:0002529)2.03905748
101Mucopolysacchariduria (HP:0008155)2.03348090
102Urinary glycosaminoglycan excretion (HP:0003541)2.03348090
103Metaphyseal irregularity (HP:0003025)2.03159894
104Abnormality of the pleura (HP:0002103)2.01991187
105Nausea (HP:0002018)2.01501999
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00484054
107Abnormality of polysaccharide metabolism (HP:0011012)2.00484054
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00484054
109Petechiae (HP:0000967)2.00261737
110Emphysema (HP:0002097)2.00256582
111Arthralgia (HP:0002829)1.98038610
112Agammaglobulinemia (HP:0004432)1.97449705
113Vertigo (HP:0002321)1.97352435
114Epistaxis (HP:0000421)1.95656082
115Pulmonary embolism (HP:0002204)1.95656020
116Bone pain (HP:0002653)1.95157650
117Hypergammaglobulinemia (HP:0010702)1.94547122
118Asymmetric septal hypertrophy (HP:0001670)1.94335652
119Abnormality of the pericardium (HP:0001697)1.93555582
120Glomerulopathy (HP:0100820)1.93313402
121T lymphocytopenia (HP:0005403)1.93181403
122Prolonged neonatal jaundice (HP:0006579)1.92397376
123Increased serum ferritin (HP:0003281)1.92094773
124Cheilitis (HP:0100825)1.91850126
125Eosinophilia (HP:0001880)1.91647737
126Abnormality of T cell number (HP:0011839)1.91537576
127Chronic diarrhea (HP:0002028)1.90637722
128Vertebral compression fractures (HP:0002953)1.90528923
129Increased IgM level (HP:0003496)1.90132130
130IgA deficiency (HP:0002720)1.90129467
131Recurrent lower respiratory tract infections (HP:0002783)1.89658518
132Fatigue (HP:0012378)1.83779745
133Acne (HP:0001061)1.83290680
134Segmental peripheral demyelination/remyelination (HP:0003481)1.82472296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.69814137
2TBK13.53443655
3MAP4K13.39133146
4TYK23.29774570
5TXK3.11450839
6DDR22.92159736
7IKBKE2.78120099
8IRAK42.71590935
9RIPK42.67054449
10IKBKB2.65029768
11BLK2.58358478
12JAK12.48053964
13ERN12.45632952
14JAK32.40695770
15PRPF4B2.36660905
16TAOK32.30604380
17TAOK12.21884255
18TGFBR21.98285205
19RIPK11.95671013
20* IRAK31.91230546
21CHUK1.84083128
22MOS1.77057770
23ADRBK21.76984334
24KIT1.73472593
25EPHB11.68033104
26MST41.64058152
27ZAP701.53313422
28CSK1.52199229
29FGFR41.48339547
30STK101.48330154
31MAP3K131.44283398
32PBK1.42063684
33PIM11.41596358
34CDC42BPA1.40235232
35PIM21.39685519
36CSF1R1.35746564
37HCK1.35258879
38IRAK21.32865282
39RPS6KA41.30315342
40TEC1.28363772
41MAP3K11.27654530
42NEK91.22858404
43SYK1.20475612
44BTK1.18715061
45JAK21.15790081
46FGFR31.15313779
47EPHA31.12663454
48MARK31.12027237
49ITK1.09665662
50LYN1.08668447
51SIK11.08660497
52CAMK1D1.08344576
53LCK1.02094348
54LATS21.01155570
55MST1R0.99891139
56TYRO30.97426958
57PTK60.95986171
58MAP2K30.94422697
59BMX0.94255025
60ARAF0.93775041
61FGR0.91325110
62EIF2AK20.88209616
63ACVR1B0.87585127
64MATK0.86208687
65GRK60.84110678
66MAP3K30.78861542
67IRAK10.78418463
68TESK20.78134267
69TRPM70.75714871
70SIK30.74528428
71TRIB30.71100813
72NLK0.70570312
73ABL10.69304306
74FES0.67483927
75PDGFRA0.63813944
76CAMKK20.63565880
77PRKG20.63110713
78LRRK20.61941062
79ABL20.59181210
80DAPK20.59012007
81CDK60.58879069
82SIK20.58720973
83CDK120.57927703
84STK30.57196406
85EGFR0.56183447
86MAP3K50.53469588
87NME20.52159572
88STK40.51221820
89PRKCD0.50288240
90NUAK10.50042407
91PRKAA20.49335684
92MAP3K100.49189128
93GRK70.47396232
94MAPK150.47260281
95CLK10.45187360
96PIK3CG0.44872129
97PDGFRB0.44086946
98MAP2K60.44011448
99HIPK20.43960209
100GSK3A0.42625860
101PRKCQ0.41630012
102CAMK1G0.41467995
103YES10.41041953
104IGF1R0.40714589
105BMPR20.40554367
106MAP3K110.40357175
107MAPKAPK20.40188083
108GRK10.39858929
109MAPK70.38570072
110MAPK110.36997025
111MAPK120.36005890
112ERBB40.35879160
113MAPK40.35817884
114KDR0.35433161
115SGK30.34422013
116TIE10.33907033
117PAK40.33891090
118DYRK30.32850600
119PKN10.31935028
120TAOK20.30982828
121INSR0.30737371
122PDK10.30049013
123PDPK10.30024029
124STK240.28656369
125KSR20.27714546
126MELK0.24100704
127TTN0.21828239
128ICK0.21544324
129DAPK30.18533014
130TESK10.17807776
131MAP3K90.16538865
132MAP3K80.16007972

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.20211691
2Leishmaniasis_Homo sapiens_hsa051402.98695354
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.84401234
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78359580
5Osteoclast differentiation_Homo sapiens_hsa043802.51689370
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38744333
7Graft-versus-host disease_Homo sapiens_hsa053322.36333399
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31002254
9Legionellosis_Homo sapiens_hsa051342.18765686
10Malaria_Homo sapiens_hsa051442.06579085
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01030447
12Measles_Homo sapiens_hsa051621.99777741
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96952937
14TNF signaling pathway_Homo sapiens_hsa046681.95774720
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.95215964
16Pertussis_Homo sapiens_hsa051331.90829097
17Allograft rejection_Homo sapiens_hsa053301.83519448
18B cell receptor signaling pathway_Homo sapiens_hsa046621.80562279
19* Tuberculosis_Homo sapiens_hsa051521.79800902
20Rheumatoid arthritis_Homo sapiens_hsa053231.69196294
21Influenza A_Homo sapiens_hsa051641.68287123
22Hematopoietic cell lineage_Homo sapiens_hsa046401.66898320
23Lysosome_Homo sapiens_hsa041421.53669668
24Caffeine metabolism_Homo sapiens_hsa002321.52401833
25Complement and coagulation cascades_Homo sapiens_hsa046101.51570654
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.51269134
27Toxoplasmosis_Homo sapiens_hsa051451.49867927
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44442048
29African trypanosomiasis_Homo sapiens_hsa051431.38295259
30Primary immunodeficiency_Homo sapiens_hsa053401.37783793
31Herpes simplex infection_Homo sapiens_hsa051681.33553346
32Apoptosis_Homo sapiens_hsa042101.29119558
33Asthma_Homo sapiens_hsa053101.27554396
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.25646154
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22735560
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20852816
37Antigen processing and presentation_Homo sapiens_hsa046121.19091658
38Bladder cancer_Homo sapiens_hsa052191.17038425
39Other glycan degradation_Homo sapiens_hsa005111.16688206
40Vitamin digestion and absorption_Homo sapiens_hsa049771.14747002
41Salmonella infection_Homo sapiens_hsa051321.14464979
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11129482
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.10329399
44Hepatitis C_Homo sapiens_hsa051601.08246796
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.00470065
46PPAR signaling pathway_Homo sapiens_hsa033200.99754544
47Chemokine signaling pathway_Homo sapiens_hsa040620.99603696
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96641812
49Hepatitis B_Homo sapiens_hsa051610.94955809
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94439663
51Shigellosis_Homo sapiens_hsa051310.93858696
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93568291
53T cell receptor signaling pathway_Homo sapiens_hsa046600.93336371
54Phagosome_Homo sapiens_hsa041450.92860127
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92140938
56Autoimmune thyroid disease_Homo sapiens_hsa053200.90427832
57Arginine biosynthesis_Homo sapiens_hsa002200.89040847
58Type I diabetes mellitus_Homo sapiens_hsa049400.86985178
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.83662652
60Acute myeloid leukemia_Homo sapiens_hsa052210.74700412
61Nitrogen metabolism_Homo sapiens_hsa009100.71708415
62ABC transporters_Homo sapiens_hsa020100.71589663
63Amoebiasis_Homo sapiens_hsa051460.70645339
64VEGF signaling pathway_Homo sapiens_hsa043700.69097753
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67641491
66Histidine metabolism_Homo sapiens_hsa003400.66419504
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65553367
68Sulfur metabolism_Homo sapiens_hsa009200.64705362
69Peroxisome_Homo sapiens_hsa041460.63873328
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63257110
71Retinol metabolism_Homo sapiens_hsa008300.62155477
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61291737
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61108870
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.58735740
75Collecting duct acid secretion_Homo sapiens_hsa049660.56378754
76Fatty acid degradation_Homo sapiens_hsa000710.55496021
77Insulin resistance_Homo sapiens_hsa049310.55146164
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55132748
79Mineral absorption_Homo sapiens_hsa049780.54917259
80Viral myocarditis_Homo sapiens_hsa054160.52749469
81Tryptophan metabolism_Homo sapiens_hsa003800.51554919
82Prolactin signaling pathway_Homo sapiens_hsa049170.51278313
83Small cell lung cancer_Homo sapiens_hsa052220.51165412
84Folate biosynthesis_Homo sapiens_hsa007900.48458555
85beta-Alanine metabolism_Homo sapiens_hsa004100.47808838
86Type II diabetes mellitus_Homo sapiens_hsa049300.47102343
87Chronic myeloid leukemia_Homo sapiens_hsa052200.45748739
88Fat digestion and absorption_Homo sapiens_hsa049750.44355113
89Epstein-Barr virus infection_Homo sapiens_hsa051690.43848209
90Sphingolipid metabolism_Homo sapiens_hsa006000.43696974
91Fatty acid biosynthesis_Homo sapiens_hsa000610.42606351
92Prion diseases_Homo sapiens_hsa050200.42568977
93Pancreatic cancer_Homo sapiens_hsa052120.41922121
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41209399
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38999555
96Starch and sucrose metabolism_Homo sapiens_hsa005000.38697391
97Platelet activation_Homo sapiens_hsa046110.38605968
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37763736
99Dorso-ventral axis formation_Homo sapiens_hsa043200.36909667
100Glycerolipid metabolism_Homo sapiens_hsa005610.36213571
101Renin-angiotensin system_Homo sapiens_hsa046140.34442099
102Viral carcinogenesis_Homo sapiens_hsa052030.34185836
103HIF-1 signaling pathway_Homo sapiens_hsa040660.33989549
104Chemical carcinogenesis_Homo sapiens_hsa052040.33987718
105* Neurotrophin signaling pathway_Homo sapiens_hsa047220.33320458
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33052343
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32460362
108Renal cell carcinoma_Homo sapiens_hsa052110.31838504
109HTLV-I infection_Homo sapiens_hsa051660.30973332
110Vibrio cholerae infection_Homo sapiens_hsa051100.29900316
111MAPK signaling pathway_Homo sapiens_hsa040100.27166961
112Galactose metabolism_Homo sapiens_hsa000520.26970999
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25393119
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25267749
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24263840
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24162964
117Endocytosis_Homo sapiens_hsa041440.23503867
118FoxO signaling pathway_Homo sapiens_hsa040680.22597752
119Notch signaling pathway_Homo sapiens_hsa043300.21175462
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20870340
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20504903
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17146059
123Proteoglycans in cancer_Homo sapiens_hsa052050.15645173

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