IRAK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.99158150
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96474437
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93340962
4negative regulation of cell killing (GO:0031342)4.93340962
5* response to peptidoglycan (GO:0032494)4.67486602
6positive regulation by symbiont of host defense response (GO:0052509)4.64097310
7modulation by symbiont of host defense response (GO:0052031)4.64097310
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64097310
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64097310
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.64097310
11modulation by symbiont of host immune response (GO:0052553)4.64097310
12microglial cell activation (GO:0001774)4.56708808
13detection of bacterium (GO:0016045)4.46585481
14respiratory burst (GO:0045730)4.41115160
15positive regulation of gamma-delta T cell activation (GO:0046645)4.34178661
16immunoglobulin mediated immune response (GO:0016064)4.34038409
17leukocyte aggregation (GO:0070486)4.21951883
18macrophage activation (GO:0042116)4.07306643
19detection of biotic stimulus (GO:0009595)4.06667375
20hydrogen peroxide biosynthetic process (GO:0050665)4.05651160
21reactive oxygen species biosynthetic process (GO:1903409)3.99618754
22granulocyte activation (GO:0036230)3.88732126
23neutrophil activation (GO:0042119)3.82650868
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81853585
25neutrophil mediated immunity (GO:0002446)3.79770647
26negative regulation of erythrocyte differentiation (GO:0045647)3.75030892
27B cell mediated immunity (GO:0019724)3.74829763
28positive regulation of chemokine biosynthetic process (GO:0045080)3.65525747
29regulation of chemokine biosynthetic process (GO:0045073)3.61265072
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.59344091
31defense response to protozoan (GO:0042832)3.58117792
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57552278
33response to interferon-alpha (GO:0035455)3.56634470
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.56129208
35superoxide anion generation (GO:0042554)3.55844018
36NIK/NF-kappaB signaling (GO:0038061)3.55593682
37macrophage activation involved in immune response (GO:0002281)3.53108496
38negative regulation of T cell mediated immunity (GO:0002710)3.52306783
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.50994677
40response to host immune response (GO:0052572)3.49537449
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49537449
42regulation of leukocyte degranulation (GO:0043300)3.48667370
43response to muramyl dipeptide (GO:0032495)3.46485570
44production of molecular mediator involved in inflammatory response (GO:0002532)3.46284824
45B cell receptor signaling pathway (GO:0050853)3.42586092
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.39875712
47positive regulation of mast cell degranulation (GO:0043306)3.39875712
48response to protozoan (GO:0001562)3.38948032
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37841303
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37841303
51positive regulation of interferon-alpha production (GO:0032727)3.36355957
52negative regulation of viral genome replication (GO:0045071)3.36326487
53leukocyte migration involved in inflammatory response (GO:0002523)3.35368023
54T-helper 1 type immune response (GO:0042088)3.31880400
55regulation of mast cell degranulation (GO:0043304)3.31720385
56regulation of podosome assembly (GO:0071801)3.30830132
57regulation of interferon-beta biosynthetic process (GO:0045357)3.30178612
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28038150
59germinal center formation (GO:0002467)3.24367212
60regulation of interferon-alpha production (GO:0032647)3.23281081
61myeloid cell activation involved in immune response (GO:0002275)3.21771398
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21649233
63response to host (GO:0075136)3.21649233
64response to host defenses (GO:0052200)3.21649233
65negative regulation of leukocyte mediated immunity (GO:0002704)3.20978894
66positive regulation of B cell differentiation (GO:0045579)3.19210629
67positive regulation of mast cell activation (GO:0033005)3.18656900
68antigen processing and presentation of endogenous antigen (GO:0019883)3.16692070
69response to interferon-beta (GO:0035456)3.16435204
70regulation of mast cell activation (GO:0033003)3.14225531
71leukocyte mediated cytotoxicity (GO:0001909)3.14075223
72regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12619977
73cellular extravasation (GO:0045123)3.12616679
74regulation of mast cell activation involved in immune response (GO:0033006)3.11605319
75leukocyte degranulation (GO:0043299)3.09424204
76regulation of gamma-delta T cell activation (GO:0046643)3.09010837
77myeloid dendritic cell differentiation (GO:0043011)3.08597245
78* negative regulation of interleukin-12 production (GO:0032695)3.08532772
79type I interferon signaling pathway (GO:0060337)3.08154920
80cellular response to type I interferon (GO:0071357)3.08154920
81myeloid dendritic cell activation (GO:0001773)3.08095716
82response to type I interferon (GO:0034340)3.07767213
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.06664903
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05056702
85regulation of interleukin-8 biosynthetic process (GO:0045414)3.04623353
86positive regulation of cellular amide metabolic process (GO:0034250)3.04469059
87detection of other organism (GO:0098543)3.03757932
88interferon-gamma-mediated signaling pathway (GO:0060333)2.98282904
89regulation of gamma-delta T cell differentiation (GO:0045586)2.97483276
90regulation of B cell receptor signaling pathway (GO:0050855)2.97402326
91myeloid leukocyte mediated immunity (GO:0002444)2.96713203
92detection of molecule of bacterial origin (GO:0032490)2.95707716
93regulation of regulated secretory pathway (GO:1903305)2.95165688
94antigen processing and presentation via MHC class Ib (GO:0002475)2.94753376
95positive regulation of NF-kappaB import into nucleus (GO:0042346)2.92745824
96positive regulation of heat generation (GO:0031652)2.91698612
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91644461
98neutrophil chemotaxis (GO:0030593)2.91501227
99myeloid leukocyte activation (GO:0002274)2.90254362
100natural killer cell mediated cytotoxicity (GO:0042267)2.89377891
101natural killer cell mediated immunity (GO:0002228)2.89377891
102negative regulation of interleukin-17 production (GO:0032700)2.87647164
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87645089
104positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87632244
105positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87571989
106positive thymic T cell selection (GO:0045059)2.87000025
107neutrophil migration (GO:1990266)2.84081344
108response to fungus (GO:0009620)2.82785289
109regulation of B cell differentiation (GO:0045577)2.81985667
110negative regulation of growth of symbiont in host (GO:0044130)2.81157195
111negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81157195
112modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81157195
113regulation of growth of symbiont in host (GO:0044126)2.81157195
114mature B cell differentiation (GO:0002335)2.81090647
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79498045
116cytokine secretion (GO:0050663)2.78235425
117response to interleukin-15 (GO:0070672)2.77274107
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77248150
119negative regulation of T-helper cell differentiation (GO:0045623)2.77248150
120mast cell activation (GO:0045576)2.77196284
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.76553464
122regulation of fever generation (GO:0031620)2.76406729
123positive regulation of leukocyte degranulation (GO:0043302)2.75504086
124detection of external biotic stimulus (GO:0098581)2.75393473
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75111678
126regulation of T-helper 2 cell differentiation (GO:0045628)2.74844879
127regulation of interleukin-6 biosynthetic process (GO:0045408)2.74816129
128positive regulation of interferon-beta production (GO:0032728)2.74622330
129T cell migration (GO:0072678)2.74290022
130negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.74095110
131positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72693238
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.71575475
133leukocyte cell-cell adhesion (GO:0007159)2.70930316
134regulation of interleukin-12 biosynthetic process (GO:0045075)2.70902117
135positive regulation of antigen processing and presentation (GO:0002579)2.70128911
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69666580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.47169083
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.02257113
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.76334954
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.63855251
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.62514895
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62062828
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44399957
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.21513630
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17312917
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08134658
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94410151
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94303249
13SCL_19346495_ChIP-Seq_HPC-7_Human2.93886381
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70336935
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68927437
16E2F7_22180533_ChIP-Seq_HELA_Human2.59473123
17SPI1_23547873_ChIP-Seq_NB4_Human2.56919606
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42768956
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40905288
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36175052
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35123118
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29454336
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24555024
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20028258
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16006609
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13182806
27VDR_21846776_ChIP-Seq_THP-1_Human2.09257358
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.06515398
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02158737
30GATA1_22025678_ChIP-Seq_K562_Human2.02036080
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.99534507
32VDR_24763502_ChIP-Seq_THP-1_Human1.96515833
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93396663
34MYB_26560356_Chip-Seq_TH2_Human1.91976188
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82586566
36MAF_26560356_Chip-Seq_TH1_Human1.78736411
37MYC_22102868_ChIP-Seq_BL_Human1.78339409
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76572337
39MYB_26560356_Chip-Seq_TH1_Human1.74349935
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73801502
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67010400
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.60609746
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58100629
44RUNX_20019798_ChIP-Seq_JUKART_Human1.55385102
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54866460
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53211312
47UTX_26944678_Chip-Seq_JUKART_Human1.52653629
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51274765
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50601414
50* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50139620
51* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50036458
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49572577
53SPI1_23127762_ChIP-Seq_K562_Human1.49424758
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49325111
55* PU_27001747_Chip-Seq_BMDM_Mouse1.44107874
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43046422
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40610023
58* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39582166
59TCF7_22412390_ChIP-Seq_EML_Mouse1.39308266
60GATA1_19941826_ChIP-Seq_K562_Human1.37026135
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33716522
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30987071
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29721530
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29467991
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.24266753
66* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20081813
67GATA2_19941826_ChIP-Seq_K562_Human1.16887291
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13865585
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13857104
70MAF_26560356_Chip-Seq_TH2_Human1.13786850
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12202439
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11602968
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.11529832
74* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10189347
75GATA3_27048872_Chip-Seq_THYMUS_Human1.09422981
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09070660
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08179095
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06773733
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06426076
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02434024
81TFEB_21752829_ChIP-Seq_HELA_Human1.01405634
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01275374
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01000302
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99823983
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99270004
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97631957
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97201010
88FOXM1_23109430_ChIP-Seq_U2OS_Human0.96809376
89VDR_24787735_ChIP-Seq_THP-1_Human0.96031933
90* GATA3_26560356_Chip-Seq_TH2_Human0.95992331
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93490751
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93067914
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92625480
94* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92607658
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90915503
96SPI1_20517297_ChIP-Seq_HL60_Human0.88732941
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.88439355
98TP63_17297297_ChIP-ChIP_HaCaT_Human0.88330067
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88111505
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84182869
101NCOR1_26117541_ChIP-Seq_K562_Human0.83836051
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.82475285
103BCL6_27268052_Chip-Seq_Bcells_Human0.81838004
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81448246
105STAT1_20625510_ChIP-Seq_HELA_Human0.80842470
106SMRT_27268052_Chip-Seq_Bcells_Human0.80277676
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79364943
108MYC_18555785_ChIP-Seq_MESCs_Mouse0.78668074
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78383775
110BCOR_27268052_Chip-Seq_Bcells_Human0.75993886
111P300_27268052_Chip-Seq_Bcells_Human0.74361825
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74295002
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73786097
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73111544
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.71503910
116VDR_23849224_ChIP-Seq_CD4+_Human0.71270189
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71174555
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68715688
119KDM2B_26808549_Chip-Seq_DND41_Human0.67807172
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.65915222
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65784274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to3.70947641
2MP0001835_abnormal_antigen_presentation3.61280076
3MP0003436_decreased_susceptibility_to3.53155204
4MP0003724_increased_susceptibility_to3.24369163
5MP0003303_peritoneal_inflammation3.19032533
6MP0002148_abnormal_hypersensitivity_rea3.00281022
7* MP0002419_abnormal_innate_immunity2.99121950
8MP0005000_abnormal_immune_tolerance2.86538281
9MP0005025_abnormal_response_to2.83738704
10MP0004510_myositis2.59167983
11MP0006082_CNS_inflammation2.55399453
12MP0009278_abnormal_bone_marrow2.53908328
13MP0005671_abnormal_response_to2.52392101
14MP0001800_abnormal_humoral_immune2.52341267
15* MP0002452_abnormal_antigen_presenting2.51166124
16MP0005387_immune_system_phenotype2.49525099
17MP0001790_abnormal_immune_system2.49525099
18MP0005464_abnormal_platelet_physiology2.48328352
19* MP0000685_abnormal_immune_system2.42689715
20* MP0002723_abnormal_immune_serum2.39928436
21* MP0002420_abnormal_adaptive_immunity2.23579248
22* MP0001819_abnormal_immune_cell2.23366156
23MP0001545_abnormal_hematopoietic_system2.22400907
24MP0005397_hematopoietic_system_phenotyp2.22400907
25MP0001533_abnormal_skeleton_physiology2.06347039
26MP0002405_respiratory_system_inflammati1.99450360
27MP0004808_abnormal_hematopoietic_stem1.98179816
28MP0004947_skin_inflammation1.95689278
29MP0008260_abnormal_autophagy1.88703214
30* MP0001845_abnormal_inflammatory_respons1.84924025
31MP0002006_tumorigenesis1.84905619
32MP0000343_altered_response_to1.83030397
33MP0002398_abnormal_bone_marrow1.81786033
34MP0010155_abnormal_intestine_physiology1.76856750
35* MP0000716_abnormal_immune_system1.74114411
36MP0005058_abnormal_lysosome_morphology1.73310431
37MP0001853_heart_inflammation1.63489009
38MP0000858_altered_metastatic_potential1.57123166
39MP0002396_abnormal_hematopoietic_system1.55879666
40MP0000689_abnormal_spleen_morphology1.54359721
41MP0008469_abnormal_protein_level1.53403628
42* MP0002429_abnormal_blood_cell1.48881405
43MP0000465_gastrointestinal_hemorrhage1.48612567
44MP0003448_altered_tumor_morphology1.47729322
45MP0009333_abnormal_splenocyte_physiolog1.44724124
46* MP0002722_abnormal_immune_system1.43247584
47MP0009764_decreased_sensitivity_to1.43239180
48MP0002166_altered_tumor_susceptibility1.42963934
49MP0003172_abnormal_lysosome_physiology1.40505546
50MP0002132_abnormal_respiratory_system1.39721308
51MP0008004_abnormal_stomach_pH1.38333411
52MP0001851_eye_inflammation1.38193353
53MP0005174_abnormal_tail_pigmentation1.35168453
54MP0002254_reproductive_system_inflammat1.31757722
55MP0005167_abnormal_blood-brain_barrier1.31457013
56MP0003075_altered_response_to1.30141204
57MP0001873_stomach_inflammation1.26553951
58MP0000490_abnormal_crypts_of1.21835918
59MP0002933_joint_inflammation1.21419424
60MP0005310_abnormal_salivary_gland1.19359135
61* MP0002998_abnormal_bone_remodeling1.18334559
62MP0003763_abnormal_thymus_physiology1.18142320
63MP0003300_gastrointestinal_ulcer1.17334099
64MP0005451_abnormal_body_composition1.16332822
65MP0010352_gastrointestinal_tract_polyps1.15379608
66MP0003690_abnormal_glial_cell1.12883318
67MP0002277_abnormal_respiratory_mucosa1.09957191
68MP0003186_abnormal_redox_activity1.08654649
69MP0005076_abnormal_cell_differentiation1.06099878
70MP0005390_skeleton_phenotype1.05810222
71MP0003183_abnormal_peptide_metabolism1.03384459
72MP0005023_abnormal_wound_healing0.99397745
73MP0003828_pulmonary_edema0.99294118
74MP0004381_abnormal_hair_follicle0.95811269
75MP0000604_amyloidosis0.95173157
76MP0002009_preneoplasia0.94901391
77MP0005164_abnormal_response_to0.94821687
78MP0008438_abnormal_cutaneous_collagen0.92228257
79MP0003566_abnormal_cell_adhesion0.91800883
80MP0000703_abnormal_thymus_morphology0.89236337
81MP0010307_abnormal_tumor_latency0.89082186
82MP0001958_emphysema0.86946834
83MP0009763_increased_sensitivity_to0.86156319
84MP0003866_abnormal_defecation0.86142799
85MP0002877_abnormal_melanocyte_morpholog0.84941053
86MP0005166_decreased_susceptibility_to0.83953823
87MP0008057_abnormal_DNA_replication0.83732502
88MP0004130_abnormal_muscle_cell0.83684961
89MP0002019_abnormal_tumor_incidence0.82322620
90MP0000249_abnormal_blood_vessel0.81736560
91MP0002332_abnormal_exercise_endurance0.80700581
92MP0009765_abnormal_xenobiotic_induced0.79246460
93MP0003453_abnormal_keratinocyte_physiol0.77943979
94MP0005075_abnormal_melanosome_morpholog0.76344811
95MP0004484_altered_response_of0.75613881
96MP0003091_abnormal_cell_migration0.74666184
97MP0003191_abnormal_cellular_cholesterol0.74345200
98MP0003045_fibrosis0.74078094
99MP0006054_spinal_hemorrhage0.72595084
100MP0003221_abnormal_cardiomyocyte_apopto0.72324726
101* MP0003795_abnormal_bone_structure0.69577493
102MP0000371_diluted_coat_color0.66846640
103MP0000767_abnormal_smooth_muscle0.66060574
104MP0003705_abnormal_hypodermis_morpholog0.66036811
105MP0009840_abnormal_foam_cell0.65569665
106MP0002133_abnormal_respiratory_system0.63784026
107MP0005388_respiratory_system_phenotype0.63784026
108MP0000569_abnormal_digit_pigmentation0.60489599
109MP0004883_abnormal_blood_vessel0.60013797
110MP0003806_abnormal_nucleotide_metabolis0.59261789
111MP0001191_abnormal_skin_condition0.58395715
112MP0002138_abnormal_hepatobiliary_system0.58363649
113MP0003656_abnormal_erythrocyte_physiolo0.57471635
114MP0008873_increased_physiological_sensi0.57199852
115MP0003693_abnormal_embryo_hatching0.56250451
116MP0000313_abnormal_cell_death0.55950449
117MP0001663_abnormal_digestive_system0.55599436
118MP0000015_abnormal_ear_pigmentation0.54868800
119MP0009931_abnormal_skin_appearance0.54045662
120MP0005376_homeostasis/metabolism_phenot0.53471690
121MP0008874_decreased_physiological_sensi0.51307554

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.12123803
2Eczematoid dermatitis (HP:0000976)6.62864083
3Recurrent bacterial skin infections (HP:0005406)6.41458221
4Recurrent gram-negative bacterial infections (HP:0005420)5.55244111
5Mediastinal lymphadenopathy (HP:0100721)4.81410864
6Abnormality of macrophages (HP:0004311)4.69203780
7Myositis (HP:0100614)4.42600393
8Elevated erythrocyte sedimentation rate (HP:0003565)4.34483504
9Stomatitis (HP:0010280)4.25433966
10Obstructive lung disease (HP:0006536)4.13492558
11Chronic obstructive pulmonary disease (HP:0006510)4.13492558
12Orchitis (HP:0100796)4.02585294
13Recurrent skin infections (HP:0001581)3.93409519
14Cellulitis (HP:0100658)3.84877720
15Gingivitis (HP:0000230)3.75631566
16Optic neuritis (HP:0100653)3.73320772
17Retrobulbar optic neuritis (HP:0100654)3.73320772
18Recurrent fungal infections (HP:0002841)3.59414775
19Petechiae (HP:0000967)3.50528616
20Autoimmune thrombocytopenia (HP:0001973)3.46914827
21Thrombocytosis (HP:0001894)3.45557571
22Vasculitis (HP:0002633)3.31409768
23Amyloidosis (HP:0011034)3.27412615
24Abnormality of the nasal mucosa (HP:0000433)3.16359524
25Periodontitis (HP:0000704)3.14828519
26Urticaria (HP:0001025)3.14658576
27Spontaneous hematomas (HP:0007420)3.13286012
28Meningitis (HP:0001287)3.12290689
29Recurrent viral infections (HP:0004429)3.09949968
30Nasal polyposis (HP:0100582)3.06317180
31Prolonged bleeding time (HP:0003010)2.97212942
32T lymphocytopenia (HP:0005403)2.95291843
33Chronic otitis media (HP:0000389)2.91379057
34Abnormality of T cell number (HP:0011839)2.90604032
35Peritonitis (HP:0002586)2.86844831
36Vacuolated lymphocytes (HP:0001922)2.85307686
37Interstitial pulmonary disease (HP:0006530)2.84637647
38Hematochezia (HP:0002573)2.80707032
39Epistaxis (HP:0000421)2.79327255
40Episodic fever (HP:0001954)2.77840817
41Pustule (HP:0200039)2.73583021
42Gingival bleeding (HP:0000225)2.71349278
43Vertebral compression fractures (HP:0002953)2.68280566
44Arterial thrombosis (HP:0004420)2.66118782
45Abnormality of liposaccharide metabolism (HP:0010968)2.64944188
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.64944188
47Abnormality of glycolipid metabolism (HP:0010969)2.64944188
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.62877998
49Granulocytopenia (HP:0001913)2.60378084
50Increased cerebral lipofuscin (HP:0011813)2.59181606
51Pulmonary embolism (HP:0002204)2.58367129
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.56592373
53Osteomyelitis (HP:0002754)2.55844878
54Pulmonary infiltrates (HP:0002113)2.53285680
55Panhypogammaglobulinemia (HP:0003139)2.51748888
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50750386
57IgM deficiency (HP:0002850)2.50702809
58Recurrent bronchitis (HP:0002837)2.49312931
59Systemic lupus erythematosus (HP:0002725)2.47551443
60Tetraparesis (HP:0002273)2.46686266
61Purpura (HP:0000979)2.46081663
62Leukocytosis (HP:0001974)2.45457230
63Gangrene (HP:0100758)2.42098841
64Anorexia (HP:0002039)2.40761732
65Recurrent cutaneous fungal infections (HP:0011370)2.38087817
66Chronic mucocutaneous candidiasis (HP:0002728)2.38087817
67Keratoconjunctivitis sicca (HP:0001097)2.35381559
68Gastrointestinal stroma tumor (HP:0100723)2.33415647
69Agnosia (HP:0010524)2.30273137
70Inflammation of the large intestine (HP:0002037)2.29663985
71Abnormality of T cell physiology (HP:0011840)2.29599558
72Recurrent pneumonia (HP:0006532)2.28908981
73Hemoptysis (HP:0002105)2.28606625
74Recurrent lower respiratory tract infections (HP:0002783)2.28075660
75Vertigo (HP:0002321)2.27344868
76Chest pain (HP:0100749)2.26873844
77Eosinophilia (HP:0001880)2.26394300
78Abnormality of the pleura (HP:0002103)2.24971792
79Gastrointestinal inflammation (HP:0004386)2.20689705
80Abnormality of the peritoneum (HP:0002585)2.18787566
81Colitis (HP:0002583)2.17856337
82Abnormal platelet volume (HP:0011876)2.12407714
83Basal ganglia calcification (HP:0002135)2.11895053
84Sepsis (HP:0100806)2.11818749
85Keratoconjunctivitis (HP:0001096)2.11198151
86Viral hepatitis (HP:0006562)2.10924320
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.10303247
88Hypergammaglobulinemia (HP:0010702)2.10220535
89Autoimmune hemolytic anemia (HP:0001890)2.09675421
90Amaurosis fugax (HP:0100576)2.06824537
91Hypochromic anemia (HP:0001931)2.05436186
92Abnormality of the endocardium (HP:0004306)2.05128354
93Hypochromic microcytic anemia (HP:0004840)2.04503821
94Glomerulopathy (HP:0100820)2.04332552
95Agammaglobulinemia (HP:0004432)2.04183733
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03855958
97Abnormality of iron homeostasis (HP:0011031)2.03592731
98Mucopolysacchariduria (HP:0008155)2.02351338
99Urinary glycosaminoglycan excretion (HP:0003541)2.02351338
100Prostate neoplasm (HP:0100787)2.02279183
101Lymphopenia (HP:0001888)2.01575529
102Gastrointestinal infarctions (HP:0005244)2.01003023
103Skin ulcer (HP:0200042)2.00847144
104Increased IgM level (HP:0003496)2.00306168
105Dysostosis multiplex (HP:0000943)2.00185901
106Thrombophlebitis (HP:0004418)1.98909372
107Thick nail (HP:0001805)1.98792654
108Increased IgE level (HP:0003212)1.97932211
109Abnormality of the prostate (HP:0008775)1.96868352
110Impaired platelet aggregation (HP:0003540)1.96454136
111Abnormal platelet function (HP:0011869)1.96454136
112Myocardial infarction (HP:0001658)1.96060293
113Polyneuropathy (HP:0001271)1.94220401
114Microcytic anemia (HP:0001935)1.93078720
115Emphysema (HP:0002097)1.92631063
116Encephalitis (HP:0002383)1.91486930
117Hepatosplenomegaly (HP:0001433)1.90358734
118Deformed sella turcica (HP:0002681)1.89462719
119Acute hepatic failure (HP:0006554)1.88072432
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87736532
121Osteolytic defects of the hand bones (HP:0009699)1.87176495
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.87176495
123Glomerulonephritis (HP:0000099)1.86017268
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84267738
125Abnormality of the pericardium (HP:0001697)1.83089129
126Fatigue (HP:0012378)1.83046317
127Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82984278
128Abnormality of polysaccharide metabolism (HP:0011012)1.82984278
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82984278
130Premature loss of primary teeth (HP:0006323)1.82586800
131J-shaped sella turcica (HP:0002680)1.81703674
132Abnormality of T cells (HP:0002843)1.81367076
133Recurrent sinusitis (HP:0011108)1.80265136
134Increased serum ferritin (HP:0003281)1.80034162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.29314506
2BLK3.54998980
3IRAK43.16740919
4MAP3K143.08974183
5MAP4K12.97583726
6KIT2.95348804
7TBK12.75365346
8IRAK32.72690485
9MAP2K32.69319054
10IKBKB2.30424247
11ERN12.27192181
12IKBKE2.24572762
13PRPF4B2.15957897
14TYK22.13786561
15JAK32.09004958
16TGFBR21.93463354
17STK101.91035946
18TXK1.84469546
19ZAP701.80133829
20BTK1.78258200
21PIM21.67397941
22MATK1.61923423
23CSK1.58202263
24TEC1.53086539
25TNK21.52973856
26RPS6KA41.51863722
27PIM11.44428986
28SYK1.41934324
29IRAK11.37372586
30NME21.36020731
31TRIB31.35525046
32CHUK1.29370903
33MAP3K31.28638426
34TGFBR11.28253653
35LRRK21.26198691
36CSF1R1.21535908
37PBK1.20723567
38MAP3K131.19893704
39JAK11.19646762
40HCK1.17830847
41IRAK21.14775470
42ITK1.12999727
43LYN1.12454472
44TESK11.08866335
45MARK31.08571494
46TESK21.06642410
47EPHB11.06577541
48TAOK11.05285306
49LCK0.99344489
50FES0.98407147
51PRKG20.94327793
52MAP3K110.86940802
53MAP3K20.84444401
54JAK20.84035424
55MAP3K120.82981569
56TAOK30.82524313
57STK40.82121205
58NLK0.81643736
59NEK20.81548092
60EIF2AK20.81132668
61YES10.80182497
62MST40.79341812
63MARK20.77816089
64KSR20.76894196
65CDK120.76519639
66MAPK70.75980536
67PDPK10.72716091
68MAPK120.72383578
69GRK70.71860833
70CDK40.71291568
71PTK2B0.71057877
72KDR0.69893571
73NEK90.67758103
74MAP3K60.66870441
75WEE10.66240862
76FGR0.65777570
77DAPK20.63812441
78HIPK20.61236650
79GRK60.60425424
80PAK40.60410684
81CLK10.59508088
82TAOK20.59295513
83MAP3K70.59172235
84WNK10.57588276
85MAP2K40.57094895
86CDC42BPA0.55516517
87SGK30.55439307
88MOS0.55207130
89ABL10.55107925
90TIE10.54967789
91FYN0.53258950
92PRKCD0.52491227
93ALK0.51931621
94EGFR0.51822455
95CDK60.51669349
96MAP3K100.51416390
97SGK20.50417994
98BMX0.49547877
99TRPM70.49348886
100SIK30.48832590
101EEF2K0.48815890
102MAPK40.47249345
103SRPK10.47234025
104PRKCQ0.46846387
105RET0.46017299
106MAP3K50.45814458
107TTN0.45749456
108MAPKAPK20.45686370
109BRSK20.45171586
110PKN20.45082447
111CDK190.44654984
112MAP3K10.44329292
113ABL20.43612886
114PRKD20.42770533
115CDK70.42753798
116EPHA30.41041366
117RPS6KA60.40684680
118CAMKK20.40528670
119STK110.39964191
120MAP2K60.39552349
121BMPR20.38981365
122PDK10.38773075
123STK30.36211537
124PTK60.36205113
125PIK3CG0.36177083
126RPS6KB20.35650468
127ATR0.34996891
128EIF2AK30.34121140
129PDGFRB0.33381852
130RAF10.32369071
131DYRK1B0.31019312
132MAP3K80.30502068
133FRK0.30092413
134FGFR30.29874075
135FLT30.28747388
136SIK20.28085362
137RPS6KC10.27995899
138RPS6KL10.27995899
139PRKAA20.26845886

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.60432934
2Asthma_Homo sapiens_hsa053102.98854287
3Staphylococcus aureus infection_Homo sapiens_hsa051502.61159109
4Legionellosis_Homo sapiens_hsa051342.55783419
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.45546539
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.40678566
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39884440
8Graft-versus-host disease_Homo sapiens_hsa053322.37351310
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37323653
10Osteoclast differentiation_Homo sapiens_hsa043802.34787909
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30067742
12Malaria_Homo sapiens_hsa051442.23552844
13Pertussis_Homo sapiens_hsa051332.12790599
14Allograft rejection_Homo sapiens_hsa053302.10380828
15Measles_Homo sapiens_hsa051622.02618082
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97771411
17Hematopoietic cell lineage_Homo sapiens_hsa046401.96531147
18B cell receptor signaling pathway_Homo sapiens_hsa046621.95634739
19Tuberculosis_Homo sapiens_hsa051521.90217560
20TNF signaling pathway_Homo sapiens_hsa046681.82561364
21Salmonella infection_Homo sapiens_hsa051321.69989977
22Herpes simplex infection_Homo sapiens_hsa051681.65687191
23Influenza A_Homo sapiens_hsa051641.62078576
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.56979525
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.51144177
26Toxoplasmosis_Homo sapiens_hsa051451.48408943
27Shigellosis_Homo sapiens_hsa051311.46387155
28Type I diabetes mellitus_Homo sapiens_hsa049401.46168138
29Rheumatoid arthritis_Homo sapiens_hsa053231.45839708
30African trypanosomiasis_Homo sapiens_hsa051431.41432872
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40867202
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36686359
33Antigen processing and presentation_Homo sapiens_hsa046121.34282410
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30138038
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28765266
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28752196
37Apoptosis_Homo sapiens_hsa042101.26652620
38Chemokine signaling pathway_Homo sapiens_hsa040621.23980986
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.23805747
40Acute myeloid leukemia_Homo sapiens_hsa052211.21696428
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18741305
42Primary immunodeficiency_Homo sapiens_hsa053401.17202322
43Non-small cell lung cancer_Homo sapiens_hsa052231.14073160
44Other glycan degradation_Homo sapiens_hsa005111.10862913
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09756735
46Phagosome_Homo sapiens_hsa041451.08986598
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.07044730
48Lysosome_Homo sapiens_hsa041421.06706857
49Hepatitis B_Homo sapiens_hsa051611.04698852
50Platelet activation_Homo sapiens_hsa046111.00028368
51Dorso-ventral axis formation_Homo sapiens_hsa043200.95748248
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95496347
53Ribosome_Homo sapiens_hsa030100.89734435
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88764891
55Chronic myeloid leukemia_Homo sapiens_hsa052200.87342034
56DNA replication_Homo sapiens_hsa030300.85961429
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85328388
58Amoebiasis_Homo sapiens_hsa051460.85172253
59Epstein-Barr virus infection_Homo sapiens_hsa051690.83189421
60Hepatitis C_Homo sapiens_hsa051600.78416049
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77736553
62Renal cell carcinoma_Homo sapiens_hsa052110.75611844
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75312813
64* Neurotrophin signaling pathway_Homo sapiens_hsa047220.73639852
65T cell receptor signaling pathway_Homo sapiens_hsa046600.70430376
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69213329
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69002277
68p53 signaling pathway_Homo sapiens_hsa041150.68165910
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65484318
70Pentose phosphate pathway_Homo sapiens_hsa000300.65434047
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.63047709
72Autoimmune thyroid disease_Homo sapiens_hsa053200.60907581
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.60649366
74GnRH signaling pathway_Homo sapiens_hsa049120.60341380
75Base excision repair_Homo sapiens_hsa034100.59961249
76Small cell lung cancer_Homo sapiens_hsa052220.58068621
77Pancreatic cancer_Homo sapiens_hsa052120.57826370
78Viral carcinogenesis_Homo sapiens_hsa052030.56932081
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56218227
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55254350
81HIF-1 signaling pathway_Homo sapiens_hsa040660.54843968
82Choline metabolism in cancer_Homo sapiens_hsa052310.54838556
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54237647
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52974672
85mTOR signaling pathway_Homo sapiens_hsa041500.52923585
86Viral myocarditis_Homo sapiens_hsa054160.52889719
87Caffeine metabolism_Homo sapiens_hsa002320.52618625
88Prolactin signaling pathway_Homo sapiens_hsa049170.49125074
89Endocytosis_Homo sapiens_hsa041440.48076650
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47510963
91MAPK signaling pathway_Homo sapiens_hsa040100.45104291
92Type II diabetes mellitus_Homo sapiens_hsa049300.44794580
93Regulation of autophagy_Homo sapiens_hsa041400.44324078
94Inositol phosphate metabolism_Homo sapiens_hsa005620.43839647
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42900537
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42253700
97Endometrial cancer_Homo sapiens_hsa052130.41416518
98HTLV-I infection_Homo sapiens_hsa051660.40778313
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40505746
100VEGF signaling pathway_Homo sapiens_hsa043700.37857951
101Mismatch repair_Homo sapiens_hsa034300.36883315
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.36116793
103Proteasome_Homo sapiens_hsa030500.35219914
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.34960726
105Colorectal cancer_Homo sapiens_hsa052100.33944600
106Prion diseases_Homo sapiens_hsa050200.32224212
107Prostate cancer_Homo sapiens_hsa052150.32081863
108Systemic lupus erythematosus_Homo sapiens_hsa053220.30913285
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30592388
110Arachidonic acid metabolism_Homo sapiens_hsa005900.29834576
111Insulin resistance_Homo sapiens_hsa049310.29324447
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28050988
113Complement and coagulation cascades_Homo sapiens_hsa046100.27009158
114Proteoglycans in cancer_Homo sapiens_hsa052050.27004798
115Notch signaling pathway_Homo sapiens_hsa043300.26716750
116Homologous recombination_Homo sapiens_hsa034400.26547704
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26348208
118Pyrimidine metabolism_Homo sapiens_hsa002400.25766117
119MicroRNAs in cancer_Homo sapiens_hsa052060.23408033
120Fanconi anemia pathway_Homo sapiens_hsa034600.22895566
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22865993
122FoxO signaling pathway_Homo sapiens_hsa040680.21814232
123Selenocompound metabolism_Homo sapiens_hsa004500.20578507

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