IRAK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.85317465
2negative regulation of cell killing (GO:0031342)5.55936076
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.55936076
4neutrophil activation involved in immune response (GO:0002283)4.66169008
5antigen processing and presentation of endogenous antigen (GO:0019883)4.55291783
6negative T cell selection (GO:0043383)4.53141049
7negative thymic T cell selection (GO:0045060)4.45763669
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41394816
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41394816
10cellular response to interleukin-15 (GO:0071350)4.32302843
11response to interleukin-15 (GO:0070672)4.29618316
12regulation of gamma-delta T cell differentiation (GO:0045586)4.07799039
13negative regulation of T cell mediated immunity (GO:0002710)4.03838986
14microglial cell activation (GO:0001774)4.00926195
15response to peptidoglycan (GO:0032494)3.93546834
16positive regulation of gamma-delta T cell activation (GO:0046645)3.85947394
17positive T cell selection (GO:0043368)3.85609306
18production of molecular mediator involved in inflammatory response (GO:0002532)3.83431890
19immunoglobulin mediated immune response (GO:0016064)3.83038894
20respiratory burst (GO:0045730)3.78565367
21regulation of B cell receptor signaling pathway (GO:0050855)3.74459410
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.74102995
23negative regulation of phagocytosis (GO:0050765)3.63091560
24activated T cell proliferation (GO:0050798)3.62390798
25positive regulation of granulocyte differentiation (GO:0030854)3.61129697
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.59983158
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57396796
28positive regulation of B cell differentiation (GO:0045579)3.56486590
29regulation of T cell mediated cytotoxicity (GO:0001914)3.50487820
30positive regulation of interferon-alpha production (GO:0032727)3.49445749
31T cell selection (GO:0045058)3.49385059
32positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48256441
33positive thymic T cell selection (GO:0045059)3.46447090
34neutrophil activation (GO:0042119)3.46265977
35autophagic vacuole fusion (GO:0000046)3.45966701
36regulation of alpha-beta T cell proliferation (GO:0046640)3.45605931
37regulation of interferon-beta biosynthetic process (GO:0045357)3.41254661
38response to interferon-beta (GO:0035456)3.41124040
39leukocyte aggregation (GO:0070486)3.39222281
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36831093
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.36831093
42modulation by symbiont of host immune response (GO:0052553)3.36831093
43positive regulation by symbiont of host defense response (GO:0052509)3.36831093
44modulation by symbiont of host defense response (GO:0052031)3.36831093
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36831093
46positive regulation of natural killer cell differentiation (GO:0032825)3.36055015
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34581504
48regulation of regulatory T cell differentiation (GO:0045589)3.34293555
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34228784
50cellular response to interferon-beta (GO:0035458)3.33606273
51regulation of interferon-alpha production (GO:0032647)3.33193833
52negative regulation of leukocyte mediated immunity (GO:0002704)3.29743273
53myeloid dendritic cell activation (GO:0001773)3.25213351
54response to type I interferon (GO:0034340)3.24981453
55regulation of T cell tolerance induction (GO:0002664)3.24703328
56type I interferon signaling pathway (GO:0060337)3.24509357
57cellular response to type I interferon (GO:0071357)3.24509357
58positive regulation of antigen processing and presentation (GO:0002579)3.23355065
59granulocyte activation (GO:0036230)3.23295993
60regulation of B cell differentiation (GO:0045577)3.19627727
61tolerance induction (GO:0002507)3.16952386
62dendritic cell chemotaxis (GO:0002407)3.16867929
63detection of bacterium (GO:0016045)3.15562230
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14814101
65negative regulation of T-helper cell differentiation (GO:0045623)3.14814101
66antigen processing and presentation via MHC class Ib (GO:0002475)3.12145326
67cellular defense response (GO:0006968)3.10823013
68cellular response to zinc ion (GO:0071294)3.09715106
69T cell migration (GO:0072678)3.09050401
70regulation of tolerance induction (GO:0002643)3.08634997
71negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08104049
72positive regulation of defense response to virus by host (GO:0002230)3.08000937
73interferon-gamma-mediated signaling pathway (GO:0060333)3.07671777
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07445376
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06087216
76organelle membrane fusion (GO:0090174)3.05389863
77mast cell activation (GO:0045576)3.05356168
78macrophage activation (GO:0042116)3.05072063
79thymic T cell selection (GO:0045061)3.01791143
80dendritic cell migration (GO:0036336)3.01190838
81regulation of interleukin-12 biosynthetic process (GO:0045075)3.00787147
82superoxide anion generation (GO:0042554)3.00378028
83myeloid cell activation involved in immune response (GO:0002275)2.96152928
84mature B cell differentiation involved in immune response (GO:0002313)2.95605565
85B cell mediated immunity (GO:0019724)2.95420209
86regulation of RIG-I signaling pathway (GO:0039535)2.95080500
87regulation of mast cell activation involved in immune response (GO:0033006)2.94979776
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94196688
89regulation of leukocyte mediated cytotoxicity (GO:0001910)2.94191882
90pinocytosis (GO:0006907)2.93933573
91definitive hemopoiesis (GO:0060216)2.93565191
92cellular extravasation (GO:0045123)2.92569317
93negative regulation of alpha-beta T cell activation (GO:0046636)2.92230642
94regulation of natural killer cell mediated immunity (GO:0002715)2.92188617
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92188617
96positive regulation of tolerance induction (GO:0002645)2.90729200
97regulation of antigen processing and presentation (GO:0002577)2.89248813
98NIK/NF-kappaB signaling (GO:0038061)2.88702385
99neutrophil mediated immunity (GO:0002446)2.88261454
100defense response to protozoan (GO:0042832)2.86116955
101reactive oxygen species biosynthetic process (GO:1903409)2.84742136
102positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84617441
103detection of external biotic stimulus (GO:0098581)2.82795439
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.82087154
105response to protozoan (GO:0001562)2.80549616
106negative regulation of interleukin-6 production (GO:0032715)2.80547615
107negative regulation of adaptive immune response (GO:0002820)2.79974767
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79899853
109cytidine catabolic process (GO:0006216)2.78796512
110response to interferon-alpha (GO:0035455)2.78552452
111cellular response to exogenous dsRNA (GO:0071360)2.77701927
112positive regulation of interferon-beta production (GO:0032728)2.76754734
113megakaryocyte development (GO:0035855)2.76225920
114interferon-gamma production (GO:0032609)2.75566091
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74824017
116response to muramyl dipeptide (GO:0032495)2.73970487
117actin nucleation (GO:0045010)2.73598108
118hepatocyte apoptotic process (GO:0097284)2.69712288
119regulation of mast cell activation (GO:0033003)2.69366154
120macrophage activation involved in immune response (GO:0002281)2.69026824
121negative regulation of interleukin-12 production (GO:0032695)2.68737479
122mature B cell differentiation (GO:0002335)2.66430655
123detection of other organism (GO:0098543)2.66289163
124B cell receptor signaling pathway (GO:0050853)2.65633004
125hydrogen peroxide biosynthetic process (GO:0050665)2.63581832
126myeloid leukocyte activation (GO:0002274)2.63053918
127regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62177764
128lipoxygenase pathway (GO:0019372)2.61766399
129myeloid dendritic cell differentiation (GO:0043011)2.61475060
130regulation of natural killer cell differentiation (GO:0032823)2.60793344
131leukocyte degranulation (GO:0043299)2.59704685
132germinal center formation (GO:0002467)2.57255673
133angiogenesis involved in wound healing (GO:0060055)2.56742543
134leukocyte mediated cytotoxicity (GO:0001909)2.55395111
135negative regulation of granulocyte differentiation (GO:0030853)2.55381645
136positive regulation of T cell migration (GO:2000406)2.55164694
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49581607
138positive regulation of macrophage differentiation (GO:0045651)2.49288002
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48956317
140response to host immune response (GO:0052572)2.48956317
141regulation of growth of symbiont in host (GO:0044126)2.48775092
142negative regulation of growth of symbiont in host (GO:0044130)2.48775092
143negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.48775092
144modulation of growth of symbiont involved in interaction with host (GO:0044144)2.48775092
145response to fungus (GO:0009620)2.48688229
146regulation of gamma-delta T cell activation (GO:0046643)2.47334358
147regulation of mast cell degranulation (GO:0043304)2.46373347
148positive regulation of mast cell activation (GO:0033005)2.45869825
149negative regulation of mast cell activation (GO:0033004)2.45410690
150regulation of T cell receptor signaling pathway (GO:0050856)2.45309251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.58700134
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.68429845
3E2F7_22180533_ChIP-Seq_HELA_Human4.63440217
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.22642882
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89730255
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83501978
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37808471
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.29483047
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23913443
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17367698
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07661060
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96620898
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94234705
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81236985
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.77938276
16SCL_19346495_ChIP-Seq_HPC-7_Human2.74331956
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55005075
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54238054
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52487096
20* SPI1_23547873_ChIP-Seq_NB4_Human2.46518433
21GATA1_22025678_ChIP-Seq_K562_Human2.43897497
22* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39619285
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38698619
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12239836
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07956898
26MYB_26560356_Chip-Seq_TH2_Human2.06617402
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06351013
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99510745
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99221610
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.92446471
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88419204
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.85470417
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84050118
34MYB_26560356_Chip-Seq_TH1_Human1.80171710
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79832319
36RUNX_20019798_ChIP-Seq_JUKART_Human1.79381693
37MAF_26560356_Chip-Seq_TH1_Human1.74781442
38VDR_21846776_ChIP-Seq_THP-1_Human1.72167658
39VDR_24763502_ChIP-Seq_THP-1_Human1.70639429
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63259672
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62949064
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61381774
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61136205
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59862866
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59657221
46PU_27001747_Chip-Seq_BMDM_Mouse1.57637320
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50686846
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.50654972
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47843508
50UTX_26944678_Chip-Seq_JUKART_Human1.40832388
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40466515
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39488759
53MYC_22102868_ChIP-Seq_BL_Human1.39296688
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37990771
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33675471
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33290775
57SPI1_23127762_ChIP-Seq_K562_Human1.31727426
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30864962
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30820511
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29685486
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23910264
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23592226
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19850979
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19035985
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15989628
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15102496
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14555657
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14523513
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.13643212
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13643013
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12473101
72GATA3_27048872_Chip-Seq_THYMUS_Human1.11672018
73SMRT_27268052_Chip-Seq_Bcells_Human1.10855518
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09758023
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09647983
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08416341
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07810074
78* GATA3_26560356_Chip-Seq_TH2_Human1.07359199
79GATA1_19941826_ChIP-Seq_K562_Human1.07061891
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06551319
81ELK1_19687146_ChIP-ChIP_HELA_Human1.03321546
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03098567
83TCF7_22412390_ChIP-Seq_EML_Mouse1.02537451
84VDR_23849224_ChIP-Seq_CD4+_Human1.01987202
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00680051
86MAF_26560356_Chip-Seq_TH2_Human1.00091638
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99473895
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98167711
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.96866528
90FOXM1_23109430_ChIP-Seq_U2OS_Human0.96389525
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95118651
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94780929
93ZNF274_21170338_ChIP-Seq_K562_Hela0.94581953
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93834948
95FOXP3_21729870_ChIP-Seq_TREG_Human0.93513785
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93120785
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.92641930
98ER_23166858_ChIP-Seq_MCF-7_Human0.90299888
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89908920
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88338394
101GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88264065
102* GATA3_26560356_Chip-Seq_TH1_Human0.87333959
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87248501
104* GATA1_19941827_ChIP-Seq_MEL_Mouse0.87158280
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85100927
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.84832969
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.84542486
108TFEB_21752829_ChIP-Seq_HELA_Human0.83849607
109VDR_24787735_ChIP-Seq_THP-1_Human0.83110520
110AR_20517297_ChIP-Seq_VCAP_Human0.81960745
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80988360
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80729705
113GABP_17652178_ChIP-ChIP_JURKAT_Human0.80728768
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80413456
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78978325
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78835012
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78638775
118BCAT_22108803_ChIP-Seq_LS180_Human0.77690543
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77288859
120IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76876810
121* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75259718
122STAT1_20625510_ChIP-Seq_HELA_Human0.74796440
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.74156612
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73844632
125TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73767692
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73577179
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73560135
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.72816110
129FOXA1_21572438_ChIP-Seq_LNCaP_Human0.72276360
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.72160588
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71831497
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70698997
133ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70392159
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69920976
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.69815399
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.69698596
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.68299086
138GATA2_19941826_ChIP-Seq_K562_Human0.66234460
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.64711462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45499442
2MP0003436_decreased_susceptibility_to3.34986649
3MP0009785_altered_susceptibility_to3.27094343
4MP0002148_abnormal_hypersensitivity_rea2.98930631
5* MP0002419_abnormal_innate_immunity2.86503769
6MP0005671_abnormal_response_to2.84728010
7MP0005000_abnormal_immune_tolerance2.76240637
8* MP0005025_abnormal_response_to2.75602057
9MP0003724_increased_susceptibility_to2.67448965
10MP0000685_abnormal_immune_system2.65522195
11MP0001800_abnormal_humoral_immune2.61153375
12MP0002396_abnormal_hematopoietic_system2.59871335
13* MP0002452_abnormal_antigen_presenting2.53188852
14MP0005387_immune_system_phenotype2.52624040
15MP0001790_abnormal_immune_system2.52624040
16* MP0002723_abnormal_immune_serum2.36233824
17* MP0002420_abnormal_adaptive_immunity2.31897820
18* MP0001819_abnormal_immune_cell2.31146427
19MP0005464_abnormal_platelet_physiology2.26680108
20MP0001853_heart_inflammation2.17046244
21MP0002166_altered_tumor_susceptibility2.08018274
22* MP0002398_abnormal_bone_marrow1.93480840
23MP0002405_respiratory_system_inflammati1.93300959
24MP0010155_abnormal_intestine_physiology1.87933785
25MP0002006_tumorigenesis1.84904156
26MP0006082_CNS_inflammation1.83692941
27* MP0000716_abnormal_immune_system1.83419850
28MP0003763_abnormal_thymus_physiology1.83010218
29MP0001533_abnormal_skeleton_physiology1.78123232
30MP0005174_abnormal_tail_pigmentation1.74882011
31MP0005058_abnormal_lysosome_morphology1.73746097
32MP0009333_abnormal_splenocyte_physiolog1.73111259
33* MP0001845_abnormal_inflammatory_respons1.68449869
34MP0000689_abnormal_spleen_morphology1.68427214
35MP0001545_abnormal_hematopoietic_system1.64848445
36MP0005397_hematopoietic_system_phenotyp1.64848445
37MP0003191_abnormal_cellular_cholesterol1.62316000
38MP0000465_gastrointestinal_hemorrhage1.59304025
39MP0004808_abnormal_hematopoietic_stem1.58989899
40* MP0002429_abnormal_blood_cell1.58884434
41MP0000343_altered_response_to1.56887244
42MP0002722_abnormal_immune_system1.55982452
43MP0003303_peritoneal_inflammation1.54489218
44MP0000858_altered_metastatic_potential1.50310809
45MP0004381_abnormal_hair_follicle1.49744344
46* MP0008469_abnormal_protein_level1.45208033
47MP0009764_decreased_sensitivity_to1.40442096
48MP0000490_abnormal_crypts_of1.38400908
49MP0004947_skin_inflammation1.36380068
50MP0003172_abnormal_lysosome_physiology1.34038060
51MP0004782_abnormal_surfactant_physiolog1.33592250
52MP0001873_stomach_inflammation1.33378238
53MP0003448_altered_tumor_morphology1.30892699
54MP0006054_spinal_hemorrhage1.28467318
55MP0003183_abnormal_peptide_metabolism1.28328209
56MP0000015_abnormal_ear_pigmentation1.24047847
57MP0003045_fibrosis1.22279550
58MP0003186_abnormal_redox_activity1.21103185
59MP0009278_abnormal_bone_marrow1.21033572
60MP0009840_abnormal_foam_cell1.19712195
61MP0008007_abnormal_cellular_replicative1.17156969
62MP0004510_myositis1.16407166
63MP0001986_abnormal_taste_sensitivity1.14239811
64MP0003300_gastrointestinal_ulcer1.11342996
65MP0008057_abnormal_DNA_replication1.11271059
66MP0005310_abnormal_salivary_gland1.11143633
67MP0002933_joint_inflammation1.10728576
68MP0003866_abnormal_defecation1.10419718
69MP0002877_abnormal_melanocyte_morpholog1.07023787
70MP0002998_abnormal_bone_remodeling1.05726969
71MP0003195_calcinosis1.05703180
72MP0000703_abnormal_thymus_morphology1.03744123
73MP0002876_abnormal_thyroid_physiology1.02963121
74MP0000569_abnormal_digit_pigmentation1.02445461
75MP0009763_increased_sensitivity_to1.01675453
76MP0002138_abnormal_hepatobiliary_system0.99942698
77MP0002693_abnormal_pancreas_physiology0.97601091
78MP0004130_abnormal_muscle_cell0.95398479
79MP0005075_abnormal_melanosome_morpholog0.94359031
80MP0002132_abnormal_respiratory_system0.94157222
81MP0002009_preneoplasia0.93689476
82MP0003279_aneurysm0.93173035
83MP0008260_abnormal_autophagy0.91846239
84MP0005390_skeleton_phenotype0.91805054
85MP0004147_increased_porphyrin_level0.91665924
86MP0003075_altered_response_to0.90658880
87MP0010094_abnormal_chromosome_stability0.89477266
88MP0001851_eye_inflammation0.85394312
89MP0005166_decreased_susceptibility_to0.85109905
90MP0000249_abnormal_blood_vessel0.83923477
91MP0000427_abnormal_hair_cycle0.83536861
92MP0002019_abnormal_tumor_incidence0.83443624
93MP0002095_abnormal_skin_pigmentation0.82387902
94MP0003787_abnormal_imprinting0.81827742
95MP0003943_abnormal_hepatobiliary_system0.81129349
96MP0001765_abnormal_ion_homeostasis0.77629681
97MP0010307_abnormal_tumor_latency0.77512265
98MP0008877_abnormal_DNA_methylation0.77427740
99MP0000371_diluted_coat_color0.76617405
100MP0003656_abnormal_erythrocyte_physiolo0.76559622
101MP0002928_abnormal_bile_duct0.76361135
102MP0003693_abnormal_embryo_hatching0.75147981
103MP0003828_pulmonary_edema0.74895460
104MP0003252_abnormal_bile_duct0.74336265
105MP0005164_abnormal_response_to0.72588540
106MP0008438_abnormal_cutaneous_collagen0.72347633
107MP0008058_abnormal_DNA_repair0.70155230
108MP0005023_abnormal_wound_healing0.69651807
109MP0002277_abnormal_respiratory_mucosa0.69042406
110MP0003795_abnormal_bone_structure0.67625726
111MP0003566_abnormal_cell_adhesion0.65983485
112MP0004883_abnormal_blood_vessel0.65882694
113MP0005379_endocrine/exocrine_gland_phen0.65797901
114MP0003077_abnormal_cell_cycle0.65078105
115MP0000604_amyloidosis0.64858547
116MP0002163_abnormal_gland_morphology0.64396942
117MP0002136_abnormal_kidney_physiology0.64003787
118MP0009765_abnormal_xenobiotic_induced0.62959927
119MP0000230_abnormal_systemic_arterial0.62554568
120MP0001663_abnormal_digestive_system0.62447603
121MP0008872_abnormal_physiological_respon0.61645487
122MP0005319_abnormal_enzyme/_coenzyme0.61323732
123MP0003690_abnormal_glial_cell0.59892944
124MP0001542_abnormal_bone_strength0.59029895

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.95186672
2Recurrent bacterial skin infections (HP:0005406)5.53358610
3Eczematoid dermatitis (HP:0000976)5.31194945
4Recurrent gram-negative bacterial infections (HP:0005420)4.47901231
5Myositis (HP:0100614)4.30031176
6Elevated erythrocyte sedimentation rate (HP:0003565)4.14017125
7Recurrent fungal infections (HP:0002841)3.87707841
8Recurrent viral infections (HP:0004429)3.67326847
9Recurrent skin infections (HP:0001581)3.65469146
10Mediastinal lymphadenopathy (HP:0100721)3.58318318
11Systemic lupus erythematosus (HP:0002725)3.56888034
12Orchitis (HP:0100796)3.49936721
13Retrobulbar optic neuritis (HP:0100654)3.36931143
14Optic neuritis (HP:0100653)3.36931143
15Abnormality of macrophages (HP:0004311)3.35372470
16Chronic otitis media (HP:0000389)3.34143473
17Thrombocytosis (HP:0001894)3.29166453
18Petechiae (HP:0000967)3.28386626
19Cellulitis (HP:0100658)3.23001525
20Meningitis (HP:0001287)3.13297029
21Autoimmune thrombocytopenia (HP:0001973)3.13051704
22Chronic obstructive pulmonary disease (HP:0006510)3.11549244
23Obstructive lung disease (HP:0006536)3.11549244
24Vacuolated lymphocytes (HP:0001922)3.09987562
25IgM deficiency (HP:0002850)3.06050560
26Autoimmune hemolytic anemia (HP:0001890)3.02481619
27Stomach cancer (HP:0012126)2.97379759
28Gingivitis (HP:0000230)2.97247088
29Spontaneous hematomas (HP:0007420)2.96794115
30Recurrent cutaneous fungal infections (HP:0011370)2.93657600
31Chronic mucocutaneous candidiasis (HP:0002728)2.93657600
32Vasculitis (HP:0002633)2.85086202
33Glomerulonephritis (HP:0000099)2.79432167
34Increased IgE level (HP:0003212)2.79257470
35Pustule (HP:0200039)2.77764911
36Prolonged bleeding time (HP:0003010)2.76375644
37Reduced antithrombin III activity (HP:0001976)2.76060929
38Abnormality of the prostate (HP:0008775)2.67609401
39Recurrent bronchitis (HP:0002837)2.67069986
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.65651072
41Abnormality of T cell physiology (HP:0011840)2.62342723
42Periodontitis (HP:0000704)2.61672655
43Panhypogammaglobulinemia (HP:0003139)2.59589979
44Agammaglobulinemia (HP:0004432)2.59158531
45Keratoconjunctivitis sicca (HP:0001097)2.58352725
46Leukocytosis (HP:0001974)2.56912318
47Pulmonary infiltrates (HP:0002113)2.56541313
48Osteomyelitis (HP:0002754)2.56179475
49Epistaxis (HP:0000421)2.55404947
50Hypochromic anemia (HP:0001931)2.53572375
51Gingival bleeding (HP:0000225)2.52100951
52Aplastic anemia (HP:0001915)2.51735680
53Severe visual impairment (HP:0001141)2.46472993
54Alveolar cell carcinoma (HP:0006519)2.45797381
55Arterial thrombosis (HP:0004420)2.45382576
56Encephalitis (HP:0002383)2.44073497
57Recurrent pneumonia (HP:0006532)2.43033955
58Abnormality of T cells (HP:0002843)2.41894852
59Keratoconjunctivitis (HP:0001096)2.38008954
60Eosinophilia (HP:0001880)2.36188897
61Granulocytopenia (HP:0001913)2.35240542
62Neoplasm of the tracheobronchial system (HP:0100552)2.33329021
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.32969307
64Abnormality of glycolipid metabolism (HP:0010969)2.32969307
65Abnormality of liposaccharide metabolism (HP:0010968)2.32969307
66Congenital stationary night blindness (HP:0007642)2.32877743
67Increased IgM level (HP:0003496)2.31737980
68Stomatitis (HP:0010280)2.30469676
69Joint hemorrhage (HP:0005261)2.29686065
70Hypochromic microcytic anemia (HP:0004840)2.29623683
71Hyperlipoproteinemia (HP:0010980)2.29557258
72Decreased circulating renin level (HP:0003351)2.29357595
73Purpura (HP:0000979)2.28749830
74Hemoptysis (HP:0002105)2.26266061
75Lymphopenia (HP:0001888)2.25693738
76Thyroiditis (HP:0100646)2.24790439
77Anorexia (HP:0002039)2.24779933
78Urticaria (HP:0001025)2.23635938
79Pulmonary embolism (HP:0002204)2.23190991
80Abnormal platelet volume (HP:0011876)2.22581080
81Severe combined immunodeficiency (HP:0004430)2.22030957
82Inflammation of the large intestine (HP:0002037)2.21908471
83B lymphocytopenia (HP:0010976)2.19345771
84Abnormality of B cell number (HP:0010975)2.19345771
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.19333130
86Abnormality of T cell number (HP:0011839)2.18119861
87Prostate neoplasm (HP:0100787)2.17668327
88Recurrent lower respiratory tract infections (HP:0002783)2.17044572
89Chronic diarrhea (HP:0002028)2.15249914
90Abnormality of the pleura (HP:0002103)2.14389352
91Chromsome breakage (HP:0040012)2.14331939
92Microcytic anemia (HP:0001935)2.13584211
93Joint swelling (HP:0001386)2.13510824
94Abnormality of the pericardium (HP:0001697)2.13331599
95Large for gestational age (HP:0001520)2.13151486
96Polyneuropathy (HP:0001271)2.12034386
97Gangrene (HP:0100758)2.11891251
98Basal ganglia calcification (HP:0002135)2.11670552
99T lymphocytopenia (HP:0005403)2.11577181
100Abnormality of eosinophils (HP:0001879)2.10956774
101Type I transferrin isoform profile (HP:0003642)2.10332273
102Albinism (HP:0001022)2.07984588
103Gastrointestinal inflammation (HP:0004386)2.07175822
104Sepsis (HP:0100806)2.07091397
105Combined immunodeficiency (HP:0005387)2.05895169
106Colitis (HP:0002583)2.02421364
107Abnormal platelet function (HP:0011869)2.01466346
108Impaired platelet aggregation (HP:0003540)2.01466346
109Increased neuronal autofluorescent lipopigment (HP:0002074)2.01447140
110Skin ulcer (HP:0200042)2.01062418
111IgG deficiency (HP:0004315)2.00920077
112Papilloma (HP:0012740)1.96207619
113Verrucae (HP:0200043)1.96207619
114Acute myeloid leukemia (HP:0004808)1.95263626
115Episodic fever (HP:0001954)1.95162226
116Hematochezia (HP:0002573)1.94603121
117Gastrointestinal stroma tumor (HP:0100723)1.93849302
118Abnormality of the renal cortex (HP:0011035)1.93659851
119Gastrointestinal infarctions (HP:0005244)1.93113099
120Chest pain (HP:0100749)1.92239234
121Nephritis (HP:0000123)1.91664180
122Patchy hypopigmentation of hair (HP:0011365)1.91220604
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90885396
124Agnosia (HP:0010524)1.89825887
125Lymphoma (HP:0002665)1.89565971
126Interstitial pulmonary disease (HP:0006530)1.89434326
127Abnormal rod and cone electroretinograms (HP:0008323)1.88837836
128Hypergammaglobulinemia (HP:0010702)1.88288586
129Abnormality of complement system (HP:0005339)1.87241981
130Acne (HP:0001061)1.84512569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.67199586
2MAP4K13.39151871
3TYK22.87775104
4KIT2.82617620
5TXK2.81786655
6BLK2.77225993
7IRAK32.62870595
8TEC2.61779633
9* IRAK42.56704786
10BTK2.27180583
11TBK12.20079895
12JAK32.19499993
13PIM22.16058609
14IKBKE2.15524557
15IKBKB1.93734825
16TGFBR21.90657186
17ZAP701.81507614
18AKT31.74337989
19MARK31.71349665
20TAOK31.68536902
21CSF1R1.64664605
22EPHA31.61850695
23MAP2K61.58074171
24NEK91.55699783
25JAK11.52776068
26STK101.52143716
27SYK1.45959051
28PIM11.45896430
29RPS6KA41.42767810
30RIPK41.40837017
31NME21.39765710
32CHUK1.35995009
33TRPM71.35018310
34CSK1.33658090
35TNK21.30984662
36ERN11.28597449
37ITK1.27835698
38CLK11.27572100
39MAP2K31.23666463
40LYN1.20153725
41EIF2AK21.17760634
42ZAK1.16879818
43LCK1.10731699
44HCK1.10147408
45PIK3CG1.07217002
46MATK1.06608984
47TAF11.02151147
48HIPK21.00145564
49FLT30.98887943
50FGR0.97799778
51STK40.94961085
52VRK10.93638170
53GRK70.93042640
54FGFR30.88880832
55ADRBK20.86905995
56EIF2AK30.86611177
57MAP3K30.86005901
58SGK20.85039446
59FRK0.84234902
60TAOK10.83948322
61TLK10.82313746
62PTK2B0.79272987
63TIE10.78061644
64ERBB30.77419502
65MAP2K20.76608249
66NLK0.72005852
67KDR0.71781746
68EIF2AK10.70957093
69YES10.70102138
70GRK60.70061015
71RPS6KA60.69819751
72JAK20.67814550
73INSRR0.66402081
74BMPR20.66254229
75ATR0.65441302
76PDK10.63961639
77FES0.62850428
78MAP3K10.62080407
79EPHB10.61469005
80MAPKAPK20.61245722
81DAPK20.61093474
82LRRK20.61018744
83CDK60.60442752
84MAP3K130.60047300
85MAP3K120.58618475
86FGFR40.58215993
87CAMKK20.58007649
88RPS6KL10.57662425
89RPS6KC10.57662425
90TGFBR10.57012097
91MST40.55983860
92PRKCD0.55675913
93CAMKK10.54197784
94CDC42BPA0.54156787
95PRPF4B0.53236281
96SGK30.52707037
97MAP3K100.51931540
98PRKD20.51511604
99NUAK10.48185897
100STK110.47747419
101MYLK0.46341657
102PLK40.45866409
103IRAK10.45791600
104MAPK120.45523780
105GRK10.45503212
106BRSK20.44707189
107ADRBK10.44394910
108MAPKAPK30.44392560
109MAPK70.41821471
110MAP3K110.41590854
111ABL10.41471665
112PAK40.41299048
113MAP3K20.40422166
114MELK0.39903451
115SIK20.39298687
116PRKCQ0.39298034
117PTK60.37961273
118MAP3K70.37792251
119MKNK10.37507748
120MAPK110.36640734
121PASK0.35329277
122IGF1R0.34331280
123SGK2230.33554220
124SGK4940.33554220
125CDK40.33326443
126ACVR1B0.32485001
127PAK30.32105964
128RPS6KA50.32093195
129CDK80.31789871
130PDPK10.31584138
131STK240.31326501
132SIK30.31076742
133MAPK40.30767415
134FYN0.28160665
135EEF2K0.27912374
136ABL20.27802768

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051402.80323541
2Staphylococcus aureus infection_Homo sapiens_hsa051502.79041705
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55292971
4Primary immunodeficiency_Homo sapiens_hsa053402.54104867
5* NF-kappa B signaling pathway_Homo sapiens_hsa040642.34035187
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.29965985
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15778455
8* Measles_Homo sapiens_hsa051622.11639487
9DNA replication_Homo sapiens_hsa030302.11456639
10Antigen processing and presentation_Homo sapiens_hsa046122.04181939
11Osteoclast differentiation_Homo sapiens_hsa043802.01099461
12Legionellosis_Homo sapiens_hsa051341.99273347
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90367602
14Graft-versus-host disease_Homo sapiens_hsa053321.90215634
15Hematopoietic cell lineage_Homo sapiens_hsa046401.85027242
16* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84710214
17* Pertussis_Homo sapiens_hsa051331.84593710
18Other glycan degradation_Homo sapiens_hsa005111.82462119
19Allograft rejection_Homo sapiens_hsa053301.78770212
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78271178
21Malaria_Homo sapiens_hsa051441.74351214
22Caffeine metabolism_Homo sapiens_hsa002321.73370516
23B cell receptor signaling pathway_Homo sapiens_hsa046621.70324813
24Herpes simplex infection_Homo sapiens_hsa051681.62297183
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.60319454
26Base excision repair_Homo sapiens_hsa034101.57290297
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54049564
28* Influenza A_Homo sapiens_hsa051641.42420998
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42239560
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.42138616
31* Tuberculosis_Homo sapiens_hsa051521.40063247
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36995537
33Non-homologous end-joining_Homo sapiens_hsa034501.33895148
34Apoptosis_Homo sapiens_hsa042101.33327446
35Linoleic acid metabolism_Homo sapiens_hsa005911.32816079
36Asthma_Homo sapiens_hsa053101.28898830
37* Toxoplasmosis_Homo sapiens_hsa051451.28692969
38Mismatch repair_Homo sapiens_hsa034301.26610195
39Lysosome_Homo sapiens_hsa041421.20153000
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16117375
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14442400
42TNF signaling pathway_Homo sapiens_hsa046681.13922986
43* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12756737
44Salmonella infection_Homo sapiens_hsa051321.09592257
45Homologous recombination_Homo sapiens_hsa034401.09431082
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08565591
47Shigellosis_Homo sapiens_hsa051311.08463579
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.08007434
49Hepatitis B_Homo sapiens_hsa051611.06151985
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03776265
51Regulation of autophagy_Homo sapiens_hsa041401.01415404
52Chemokine signaling pathway_Homo sapiens_hsa040621.01117189
53Complement and coagulation cascades_Homo sapiens_hsa046101.00769652
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98071116
55Phagosome_Homo sapiens_hsa041450.92081026
56Autoimmune thyroid disease_Homo sapiens_hsa053200.92003071
57p53 signaling pathway_Homo sapiens_hsa041150.90152131
58Ether lipid metabolism_Homo sapiens_hsa005650.90049509
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89756889
60Non-small cell lung cancer_Homo sapiens_hsa052230.89026565
61Dorso-ventral axis formation_Homo sapiens_hsa043200.86581376
62Rheumatoid arthritis_Homo sapiens_hsa053230.86454480
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85679147
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83571772
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82984453
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.80993862
67Hepatitis C_Homo sapiens_hsa051600.80651663
68T cell receptor signaling pathway_Homo sapiens_hsa046600.78889842
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78323989
70Viral myocarditis_Homo sapiens_hsa054160.77873721
71Fanconi anemia pathway_Homo sapiens_hsa034600.77794379
72Platelet activation_Homo sapiens_hsa046110.75154400
73Acute myeloid leukemia_Homo sapiens_hsa052210.74920557
74ABC transporters_Homo sapiens_hsa020100.74655161
75One carbon pool by folate_Homo sapiens_hsa006700.74104499
76Pyrimidine metabolism_Homo sapiens_hsa002400.72773429
77African trypanosomiasis_Homo sapiens_hsa051430.72756046
78Ribosome_Homo sapiens_hsa030100.72609768
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72538679
80Nitrogen metabolism_Homo sapiens_hsa009100.69662769
81Prolactin signaling pathway_Homo sapiens_hsa049170.68203471
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66314085
83Epstein-Barr virus infection_Homo sapiens_hsa051690.66079722
84Arachidonic acid metabolism_Homo sapiens_hsa005900.64572104
85Viral carcinogenesis_Homo sapiens_hsa052030.61652419
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60527246
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59747913
88Chronic myeloid leukemia_Homo sapiens_hsa052200.59530187
89Small cell lung cancer_Homo sapiens_hsa052220.59156875
90Protein export_Homo sapiens_hsa030600.58394277
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58167819
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57982527
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56430854
94N-Glycan biosynthesis_Homo sapiens_hsa005100.56235509
95Pancreatic cancer_Homo sapiens_hsa052120.55479863
96Galactose metabolism_Homo sapiens_hsa000520.55225787
97Renin-angiotensin system_Homo sapiens_hsa046140.54876367
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.52627903
99Type I diabetes mellitus_Homo sapiens_hsa049400.52340135
100Phototransduction_Homo sapiens_hsa047440.51829765
101FoxO signaling pathway_Homo sapiens_hsa040680.51036561
102HTLV-I infection_Homo sapiens_hsa051660.50589496
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.49174651
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49093446
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48409392
106Sphingolipid metabolism_Homo sapiens_hsa006000.46976660
107Cell cycle_Homo sapiens_hsa041100.46031015
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45606142
109RNA degradation_Homo sapiens_hsa030180.45554597
110Nucleotide excision repair_Homo sapiens_hsa034200.44885154
111VEGF signaling pathway_Homo sapiens_hsa043700.44758907
112Insulin resistance_Homo sapiens_hsa049310.44318130
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44030049
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43280736
115Systemic lupus erythematosus_Homo sapiens_hsa053220.41546537
116Pentose phosphate pathway_Homo sapiens_hsa000300.40948386
117Vitamin digestion and absorption_Homo sapiens_hsa049770.39945673
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.39384960
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39345059
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.38365394
121Amoebiasis_Homo sapiens_hsa051460.36139883
122Type II diabetes mellitus_Homo sapiens_hsa049300.34381189
123Renal cell carcinoma_Homo sapiens_hsa052110.34349155
124MAPK signaling pathway_Homo sapiens_hsa040100.33775155
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33287417
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.32796602
127Proteasome_Homo sapiens_hsa030500.32670634
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.32249537
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32105024
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31889303
131Endocytosis_Homo sapiens_hsa041440.30996746
132Prostate cancer_Homo sapiens_hsa052150.30425356
133Ovarian steroidogenesis_Homo sapiens_hsa049130.28752966
134Ras signaling pathway_Homo sapiens_hsa040140.27455347
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26672204
136mTOR signaling pathway_Homo sapiens_hsa041500.25976425

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