IRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.62443716
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.62443716
3antigen processing and presentation of endogenous antigen (GO:0019883)6.32491039
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.03832539
5negative regulation of cell killing (GO:0031342)6.03832539
6positive regulation of gamma-delta T cell activation (GO:0046645)5.50167858
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32006102
8* response to type I interferon (GO:0034340)4.73576839
9* cellular response to type I interferon (GO:0071357)4.71336030
10* type I interferon signaling pathway (GO:0060337)4.71336030
11NIK/NF-kappaB signaling (GO:0038061)4.37389492
12response to muramyl dipeptide (GO:0032495)4.37216042
13detection of other organism (GO:0098543)4.36288525
14negative regulation of interleukin-12 production (GO:0032695)4.28762516
15detection of bacterium (GO:0016045)4.21196876
16regulation of gamma-delta T cell activation (GO:0046643)4.10585800
17positive regulation of interferon-alpha production (GO:0032727)4.08810904
18* interferon-gamma-mediated signaling pathway (GO:0060333)4.04709001
19regulation of gamma-delta T cell differentiation (GO:0045586)3.96497402
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89891849
21regulation of interferon-alpha production (GO:0032647)3.88926393
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.87379042
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.84468979
24modulation by symbiont of host immune response (GO:0052553)3.84468979
25positive regulation by symbiont of host defense response (GO:0052509)3.84468979
26modulation by symbiont of host defense response (GO:0052031)3.84468979
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84468979
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84468979
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.81707043
30positive regulation of antigen processing and presentation (GO:0002579)3.77780080
31* regulation of interleukin-12 biosynthetic process (GO:0045075)3.76764122
32immunoglobulin mediated immune response (GO:0016064)3.76148068
33response to interleukin-15 (GO:0070672)3.74478181
34negative regulation of T cell mediated immunity (GO:0002710)3.72876455
35response to peptidoglycan (GO:0032494)3.67023864
36detection of external biotic stimulus (GO:0098581)3.65518502
37myeloid dendritic cell activation (GO:0001773)3.56941936
38regulation of type I interferon-mediated signaling pathway (GO:0060338)3.56672780
39cellular response to interleukin-15 (GO:0071350)3.54687411
40myeloid dendritic cell differentiation (GO:0043011)3.53954811
41cellular extravasation (GO:0045123)3.52726184
42tolerance induction (GO:0002507)3.51401383
43response to interferon-alpha (GO:0035455)3.48741340
44positive regulation of humoral immune response (GO:0002922)3.47590795
45neutrophil activation involved in immune response (GO:0002283)3.46724466
46T cell migration (GO:0072678)3.45256486
47positive thymic T cell selection (GO:0045059)3.43785567
48regulation of tolerance induction (GO:0002643)3.42345167
49detection of molecule of bacterial origin (GO:0032490)3.42342213
50negative regulation of leukocyte mediated immunity (GO:0002704)3.42288356
51microglial cell activation (GO:0001774)3.41975730
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.41315802
53defense response to protozoan (GO:0042832)3.40534745
54regulation of interferon-beta biosynthetic process (GO:0045357)3.35603549
55regulation of T cell mediated cytotoxicity (GO:0001914)3.30763424
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29376549
57regulation of response to interferon-gamma (GO:0060330)3.27604490
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27586514
59regulation of antigen processing and presentation (GO:0002577)3.27124061
60negative thymic T cell selection (GO:0045060)3.26533934
61regulation of B cell receptor signaling pathway (GO:0050855)3.26469698
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26461131
63response to protozoan (GO:0001562)3.25849726
64negative T cell selection (GO:0043383)3.24380343
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23970577
66* response to interferon-beta (GO:0035456)3.23733586
67detection of biotic stimulus (GO:0009595)3.22320572
68positive regulation of natural killer cell differentiation (GO:0032825)3.22227109
69interferon-gamma secretion (GO:0072643)3.18447491
70positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18037537
71regulation of RIG-I signaling pathway (GO:0039535)3.16490515
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15678133
73B cell receptor signaling pathway (GO:0050853)3.15640841
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14595533
75antigen processing and presentation via MHC class Ib (GO:0002475)3.13843970
76positive regulation of tolerance induction (GO:0002645)3.13247362
77negative regulation of innate immune response (GO:0045824)3.13097041
78macrophage activation (GO:0042116)3.11491355
79* cellular response to interferon-beta (GO:0035458)3.10725163
80production of molecular mediator involved in inflammatory response (GO:0002532)3.10235966
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.07410900
82regulation of natural killer cell mediated immunity (GO:0002715)3.07410900
83regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.06198918
84negative regulation of viral genome replication (GO:0045071)3.05440478
85macrophage activation involved in immune response (GO:0002281)3.05348117
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02724103
87response to host (GO:0075136)3.02724103
88response to host defenses (GO:0052200)3.02724103
89* cellular response to interferon-gamma (GO:0071346)3.00615497
90B cell mediated immunity (GO:0019724)3.00103156
91positive regulation of B cell differentiation (GO:0045579)2.99633922
92negative regulation of cytokine production involved in immune response (GO:0002719)2.97574503
93positive regulation of type 2 immune response (GO:0002830)2.95886509
94cellular response to virus (GO:0098586)2.95095292
95dendritic cell chemotaxis (GO:0002407)2.94164213
96neutrophil mediated immunity (GO:0002446)2.93159673
97* positive regulation of interferon-beta production (GO:0032728)2.89707248
98cellular response to exogenous dsRNA (GO:0071360)2.89605386
99interferon-gamma production (GO:0032609)2.88053462
100neutrophil activation (GO:0042119)2.87278065
101regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84419398
102negative regulation of T-helper cell differentiation (GO:0045623)2.84197602
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84197602
104T-helper 1 type immune response (GO:0042088)2.84188122
105leukocyte aggregation (GO:0070486)2.83104614
106activated T cell proliferation (GO:0050798)2.82257343
107regulation of mast cell degranulation (GO:0043304)2.81995446
108regulation of T-helper 1 cell differentiation (GO:0045625)2.81724700
109natural killer cell mediated cytotoxicity (GO:0042267)2.81227267
110natural killer cell mediated immunity (GO:0002228)2.81227267
111regulation of necroptotic process (GO:0060544)2.81155572
112dendritic cell differentiation (GO:0097028)2.81003752
113* positive regulation of interleukin-12 production (GO:0032735)2.80900449
114* regulation of alpha-beta T cell proliferation (GO:0046640)2.79788698
115regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79709766
116granulocyte activation (GO:0036230)2.79431877
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79325756
118cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.79192179
119positive regulation of B cell mediated immunity (GO:0002714)2.78653375
120positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78653375
121germinal center formation (GO:0002467)2.78577430
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77245609
123response to host immune response (GO:0052572)2.77245609
124leukocyte cell-cell adhesion (GO:0007159)2.77135588
125regulation of B cell differentiation (GO:0045577)2.76612657
126positive T cell selection (GO:0043368)2.73904105
127thymic T cell selection (GO:0045061)2.73741775
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73059739
129positive regulation of isotype switching (GO:0045830)2.70051170
130regulation of T cell tolerance induction (GO:0002664)2.69997246
131positive regulation of cellular amide metabolic process (GO:0034250)2.69968061
132myeloid cell activation involved in immune response (GO:0002275)2.69662501
133hepatocyte apoptotic process (GO:0097284)2.68387779
134respiratory burst (GO:0045730)2.68155056
135mature B cell differentiation (GO:0002335)2.68151172
136* response to interferon-gamma (GO:0034341)2.67448568
137positive regulation of interleukin-2 production (GO:0032743)2.66280760
138cellular response to zinc ion (GO:0071294)2.66230165
139negative regulation of lipid storage (GO:0010888)2.64256541
140JAK-STAT cascade (GO:0007259)2.64047541
141T cell selection (GO:0045058)2.62757815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.87138763
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.90453483
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.75072624
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.72408737
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.47406719
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.13046550
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.84858645
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.41407584
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37830128
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.32389625
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.15363179
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12068440
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02781179
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.97225185
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.77580093
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74394471
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63354124
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57641190
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31206915
20RUNX_20019798_ChIP-Seq_JUKART_Human2.27039076
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.24491327
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23465983
23GATA1_22025678_ChIP-Seq_K562_Human2.22813210
24MYB_26560356_Chip-Seq_TH2_Human2.21545760
25MAF_26560356_Chip-Seq_TH1_Human2.18279605
26SCL_19346495_ChIP-Seq_HPC-7_Human2.08635389
27SPI1_23547873_ChIP-Seq_NB4_Human2.02783350
28MYB_26560356_Chip-Seq_TH1_Human2.01206141
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96547892
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96527008
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95731132
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.88218340
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86091198
34VDR_21846776_ChIP-Seq_THP-1_Human1.77024097
35VDR_24763502_ChIP-Seq_THP-1_Human1.76142918
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73419081
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.73040789
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70344670
39MYC_22102868_ChIP-Seq_BL_Human1.64478027
40UTX_26944678_Chip-Seq_JUKART_Human1.59947565
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52993686
42* PU_27001747_Chip-Seq_BMDM_Mouse1.49644611
43TCF7_22412390_ChIP-Seq_EML_Mouse1.48564867
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48512873
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48366571
46* SPI1_23127762_ChIP-Seq_K562_Human1.46103606
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.45071513
48GATA3_27048872_Chip-Seq_THYMUS_Human1.42593078
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40830146
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38331458
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38235790
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.37056080
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30141034
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28584492
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26595637
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26328785
57MAF_26560356_Chip-Seq_TH2_Human1.24637918
58E2F7_22180533_ChIP-Seq_HELA_Human1.23642199
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18860373
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18147504
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17758843
62VDR_24787735_ChIP-Seq_THP-1_Human1.13994535
63GATA3_26560356_Chip-Seq_TH2_Human1.13427787
64* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12130047
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11606660
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08772428
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07790833
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07671098
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07464866
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.06721938
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05201841
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04178858
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03896302
74* BCL6_27268052_Chip-Seq_Bcells_Human1.02501343
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02035632
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00713382
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00425251
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00323631
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99886628
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99841581
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97891133
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96894631
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96706390
84LXR_22292898_ChIP-Seq_THP-1_Human0.95890293
85* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95362039
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94427411
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94412880
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94082984
89* BCOR_27268052_Chip-Seq_Bcells_Human0.92865790
90* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91130364
91* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89264154
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88268296
93EGR1_19032775_ChIP-ChIP_M12_Human0.88231103
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87495602
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86287006
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86287006
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85413186
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84940466
99KDM2B_26808549_Chip-Seq_DND41_Human0.84325358
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83299731
101* SMRT_27268052_Chip-Seq_Bcells_Human0.82686106
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.81356286
103* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80430978
104* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79553563
105* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76636667
106STAT1_20625510_ChIP-Seq_HELA_Human0.76365695
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76344786
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75861850
109RXR_22158963_ChIP-Seq_LIVER_Mouse0.75231981
110* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74756058
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74703972
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74503956
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73627498
114P300_27268052_Chip-Seq_Bcells_Human0.73293328
115* NCOR1_26117541_ChIP-Seq_K562_Human0.72861877
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72317054
117GATA1_19941826_ChIP-Seq_K562_Human0.72193477
118LXR_22158963_ChIP-Seq_LIVER_Mouse0.72048822
119GATA2_19941826_ChIP-Seq_K562_Human0.71559413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41635983
2MP0009785_altered_susceptibility_to3.55215722
3MP0003724_increased_susceptibility_to3.25977108
4* MP0003436_decreased_susceptibility_to3.14074515
5MP0005671_abnormal_response_to3.05965110
6* MP0000685_abnormal_immune_system3.01142303
7* MP0005000_abnormal_immune_tolerance2.85626329
8* MP0005387_immune_system_phenotype2.83242540
9* MP0001790_abnormal_immune_system2.83242540
10MP0002148_abnormal_hypersensitivity_rea2.82776521
11* MP0005025_abnormal_response_to2.80592476
12* MP0001800_abnormal_humoral_immune2.79015100
13MP0002166_altered_tumor_susceptibility2.67279871
14* MP0002452_abnormal_antigen_presenting2.58888650
15* MP0002419_abnormal_innate_immunity2.57049292
16* MP0002723_abnormal_immune_serum2.54184702
17MP0004510_myositis2.50506497
18MP0003303_peritoneal_inflammation2.38884400
19MP0003763_abnormal_thymus_physiology2.37884594
20* MP0001819_abnormal_immune_cell2.33248019
21* MP0002420_abnormal_adaptive_immunity2.32758279
22MP0002006_tumorigenesis2.23943951
23MP0004947_skin_inflammation2.22976345
24MP0010155_abnormal_intestine_physiology2.13818652
25MP0006082_CNS_inflammation2.13428539
26MP0001853_heart_inflammation2.03990366
27MP0009278_abnormal_bone_marrow2.03688226
28MP0002405_respiratory_system_inflammati1.98950931
29MP0003300_gastrointestinal_ulcer1.89622535
30* MP0002398_abnormal_bone_marrow1.88822581
31MP0005464_abnormal_platelet_physiology1.88520434
32MP0001845_abnormal_inflammatory_respons1.83358086
33* MP0000716_abnormal_immune_system1.83321087
34MP0001873_stomach_inflammation1.77678486
35MP0005397_hematopoietic_system_phenotyp1.75709751
36MP0001545_abnormal_hematopoietic_system1.75709751
37* MP0001533_abnormal_skeleton_physiology1.70041865
38MP0002254_reproductive_system_inflammat1.60672963
39* MP0000689_abnormal_spleen_morphology1.56466445
40MP0003448_altered_tumor_morphology1.55095931
41* MP0008469_abnormal_protein_level1.53460171
42MP0004808_abnormal_hematopoietic_stem1.52231623
43MP0003191_abnormal_cellular_cholesterol1.51669426
44MP0009333_abnormal_splenocyte_physiolog1.51214440
45MP0002722_abnormal_immune_system1.51210652
46MP0009764_decreased_sensitivity_to1.49705127
47* MP0002429_abnormal_blood_cell1.49611258
48MP0002396_abnormal_hematopoietic_system1.48455948
49MP0008260_abnormal_autophagy1.44198881
50MP0005058_abnormal_lysosome_morphology1.43613085
51MP0005451_abnormal_body_composition1.39212694
52MP0005310_abnormal_salivary_gland1.38866250
53MP0002138_abnormal_hepatobiliary_system1.35343480
54MP0003866_abnormal_defecation1.35266385
55MP0000858_altered_metastatic_potential1.32130547
56MP0002132_abnormal_respiratory_system1.25574417
57MP0009840_abnormal_foam_cell1.22448223
58MP0002009_preneoplasia1.21551194
59MP0000343_altered_response_to1.19353570
60* MP0000703_abnormal_thymus_morphology1.17197045
61MP0002998_abnormal_bone_remodeling1.15946395
62MP0000465_gastrointestinal_hemorrhage1.13772706
63MP0001851_eye_inflammation1.11885615
64MP0002933_joint_inflammation1.11340094
65MP0000569_abnormal_digit_pigmentation1.10245843
66MP0010307_abnormal_tumor_latency1.09102692
67MP0003075_altered_response_to1.06519020
68* MP0009763_increased_sensitivity_to1.04242056
69MP0005076_abnormal_cell_differentiation0.99920180
70MP0005174_abnormal_tail_pigmentation0.98936778
71MP0003453_abnormal_keratinocyte_physiol0.96805365
72MP0003828_pulmonary_edema0.96112929
73MP0003172_abnormal_lysosome_physiology0.95211125
74MP0010352_gastrointestinal_tract_polyps0.92325077
75MP0003656_abnormal_erythrocyte_physiolo0.91686314
76MP0008004_abnormal_stomach_pH0.88964378
77MP0002877_abnormal_melanocyte_morpholog0.88760051
78MP0005023_abnormal_wound_healing0.88516948
79MP0005166_decreased_susceptibility_to0.88164023
80MP0000490_abnormal_crypts_of0.86539118
81MP0003045_fibrosis0.84762061
82MP0004782_abnormal_surfactant_physiolog0.84261365
83MP0003566_abnormal_cell_adhesion0.84198779
84MP0003183_abnormal_peptide_metabolism0.82718076
85* MP0004883_abnormal_blood_vessel0.81754310
86* MP0005390_skeleton_phenotype0.81450478
87* MP0000249_abnormal_blood_vessel0.81226591
88MP0003690_abnormal_glial_cell0.78908839
89MP0003091_abnormal_cell_migration0.78192640
90MP0002277_abnormal_respiratory_mucosa0.76078193
91MP0000604_amyloidosis0.75145512
92MP0002332_abnormal_exercise_endurance0.75014763
93MP0003806_abnormal_nucleotide_metabolis0.73542569
94MP0005167_abnormal_blood-brain_barrier0.72847669
95MP0002136_abnormal_kidney_physiology0.71711341
96MP0000609_abnormal_liver_physiology0.71128352
97* MP0002019_abnormal_tumor_incidence0.66426228
98MP0001879_abnormal_lymphatic_vessel0.64523034
99MP0000767_abnormal_smooth_muscle0.64461228
100MP0003795_abnormal_bone_structure0.63134174
101MP0000015_abnormal_ear_pigmentation0.62677227
102MP0001663_abnormal_digestive_system0.62428571
103MP0004381_abnormal_hair_follicle0.60920925
104MP0005075_abnormal_melanosome_morpholog0.60623878
105MP0005381_digestive/alimentary_phenotyp0.59144750
106MP0001191_abnormal_skin_condition0.58779368
107* MP0009765_abnormal_xenobiotic_induced0.58577820
108MP0008874_decreased_physiological_sensi0.58376685
109* MP0005164_abnormal_response_to0.57432556
110MP0008007_abnormal_cellular_replicative0.57344035
111MP0003943_abnormal_hepatobiliary_system0.56159534
112MP0000371_diluted_coat_color0.55860000
113MP0004130_abnormal_muscle_cell0.55772587
114MP0002693_abnormal_pancreas_physiology0.55400162
115MP0000598_abnormal_liver_morphology0.54709671
116MP0002139_abnormal_hepatobiliary_system0.54182977
117MP0001986_abnormal_taste_sensitivity0.51788053

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.93545525
2Eczematoid dermatitis (HP:0000976)5.54100473
3Recurrent abscess formation (HP:0002722)5.36506560
4Recurrent bacterial skin infections (HP:0005406)5.10693991
5Myositis (HP:0100614)4.71113867
6Chronic otitis media (HP:0000389)4.66992406
7Recurrent fungal infections (HP:0002841)4.22912337
8Recurrent viral infections (HP:0004429)4.00079041
9Nasal polyposis (HP:0100582)3.97425929
10Abnormality of the nasal mucosa (HP:0000433)3.94528212
11Orchitis (HP:0100796)3.81425826
12Recurrent gram-negative bacterial infections (HP:0005420)3.79241691
13Recurrent bronchitis (HP:0002837)3.74751389
14Autoimmune thrombocytopenia (HP:0001973)3.74541094
15Mediastinal lymphadenopathy (HP:0100721)3.71506824
16Recurrent skin infections (HP:0001581)3.66954828
17Stomatitis (HP:0010280)3.55688037
18Abnormality of macrophages (HP:0004311)3.54105826
19Chronic mucocutaneous candidiasis (HP:0002728)3.48043398
20Recurrent cutaneous fungal infections (HP:0011370)3.48043398
21Vasculitis (HP:0002633)3.47865168
22Hematochezia (HP:0002573)3.43007916
23Optic neuritis (HP:0100653)3.41933993
24Retrobulbar optic neuritis (HP:0100654)3.41933993
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.35788229
26Spontaneous hematomas (HP:0007420)3.30275241
27Pustule (HP:0200039)3.21326133
28Colitis (HP:0002583)3.20981180
29Abnormality of T cell number (HP:0011839)3.18462230
30Interstitial pulmonary disease (HP:0006530)3.12415598
31Systemic lupus erythematosus (HP:0002725)3.11693945
32T lymphocytopenia (HP:0005403)3.06570206
33Panhypogammaglobulinemia (HP:0003139)3.03281945
34Chest pain (HP:0100749)3.00171632
35Increased IgM level (HP:0003496)3.00015015
36Inflammation of the large intestine (HP:0002037)2.98367773
37Periodontitis (HP:0000704)2.97372678
38Abnormality of T cells (HP:0002843)2.94598977
39Leukocytosis (HP:0001974)2.92349426
40Gingivitis (HP:0000230)2.91693855
41Eosinophilia (HP:0001880)2.85826080
42Hypergammaglobulinemia (HP:0010702)2.85445534
43Prostate neoplasm (HP:0100787)2.84451890
44Gastrointestinal inflammation (HP:0004386)2.83789265
45Abnormality of T cell physiology (HP:0011840)2.81072342
46Thrombocytosis (HP:0001894)2.81016073
47Pulmonary infiltrates (HP:0002113)2.79832029
48Vacuolated lymphocytes (HP:0001922)2.74080515
49Hypochromic anemia (HP:0001931)2.72776219
50Anorexia (HP:0002039)2.70522658
51Meningitis (HP:0001287)2.69185032
52Chronic sinusitis (HP:0011109)2.69146597
53Cellulitis (HP:0100658)2.67780660
54IgM deficiency (HP:0002850)2.65522916
55Pulmonary embolism (HP:0002204)2.64110280
56Basal ganglia calcification (HP:0002135)2.62255583
57Increased IgE level (HP:0003212)2.60321841
58Gangrene (HP:0100758)2.58911253
59Hemoptysis (HP:0002105)2.58182614
60Abnormality of the pleura (HP:0002103)2.57794786
61Gingival bleeding (HP:0000225)2.53554208
62Episodic fever (HP:0001954)2.52827251
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52694594
64Granulocytopenia (HP:0001913)2.51718014
65Arterial thrombosis (HP:0004420)2.49092114
66Agammaglobulinemia (HP:0004432)2.46178191
67Abnormality of eosinophils (HP:0001879)2.45704085
68Obstructive lung disease (HP:0006536)2.45655116
69Chronic obstructive pulmonary disease (HP:0006510)2.45655116
70Peritonitis (HP:0002586)2.40472418
71Osteomyelitis (HP:0002754)2.40244166
72Hypochromic microcytic anemia (HP:0004840)2.40220953
73Autoimmune hemolytic anemia (HP:0001890)2.39489515
74Thick nail (HP:0001805)2.35018420
75Keratoconjunctivitis sicca (HP:0001097)2.34342326
76Glomerulonephritis (HP:0000099)2.34322211
77Chronic diarrhea (HP:0002028)2.33899225
78Abnormality of the fingertips (HP:0001211)2.31562386
79Epistaxis (HP:0000421)2.30878427
80Myocardial infarction (HP:0001658)2.29231679
81Petechiae (HP:0000967)2.28944255
82Emphysema (HP:0002097)2.28646899
83Amyloidosis (HP:0011034)2.27916569
84Gastrointestinal infarctions (HP:0005244)2.27767609
85Abnormality of the prostate (HP:0008775)2.27028751
86Severe combined immunodeficiency (HP:0004430)2.27000627
87IgA deficiency (HP:0002720)2.26446509
88Thyroiditis (HP:0100646)2.25108724
89Abnormality of liposaccharide metabolism (HP:0010968)2.23993849
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.23993849
91Abnormality of glycolipid metabolism (HP:0010969)2.23993849
92Lymphopenia (HP:0001888)2.23531250
93Combined immunodeficiency (HP:0005387)2.23240606
94Joint swelling (HP:0001386)2.22120320
95Abnormality of cells of the lymphoid lineage (HP:0012140)2.21503514
96Urticaria (HP:0001025)2.21370613
97Keratoconjunctivitis (HP:0001096)2.20404446
98Encephalitis (HP:0002383)2.17723182
99Increased cerebral lipofuscin (HP:0011813)2.15259973
100Skin ulcer (HP:0200042)2.15215788
101Sepsis (HP:0100806)2.15092821
102IgG deficiency (HP:0004315)2.13753957
103Bronchitis (HP:0012387)2.13528390
104Abnormality of B cell number (HP:0010975)2.12919894
105B lymphocytopenia (HP:0010976)2.12919894
106Abnormality of the pericardium (HP:0001697)2.11933169
107Malnutrition (HP:0004395)2.10895960
108Glomerulopathy (HP:0100820)2.09859537
109Gastrointestinal stroma tumor (HP:0100723)2.09041045
110Prolonged bleeding time (HP:0003010)2.08299845
111Abnormality of the endocardium (HP:0004306)2.06796586
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.05886978
113Keratitis (HP:0000491)2.05563697
114Increased serum ferritin (HP:0003281)2.04750361
115Abnormality of the peritoneum (HP:0002585)2.03595048
116Vertigo (HP:0002321)2.02641477
117Cheilitis (HP:0100825)2.02520973
118Microcytic anemia (HP:0001935)2.00739195
119Acne (HP:0001061)2.00354594
120Polyneuropathy (HP:0001271)1.98374064
121Verrucae (HP:0200043)1.98113997
122Recurrent lower respiratory tract infections (HP:0002783)1.97116810
123Recurrent pneumonia (HP:0006532)1.95140180
124Esophageal varix (HP:0002040)1.93395505
125Joint hemorrhage (HP:0005261)1.91123928
126Hypoplasia of the thymus (HP:0000778)1.89199387
127Porencephaly (HP:0002132)1.88259057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.63048561
2TYK24.00157386
3IKBKE3.59801417
4TBK13.50180439
5MAP4K13.14857536
6JAK32.96636914
7IRAK42.81752151
8TXK2.78000590
9KIT2.50137267
10JAK12.44536174
11IKBKB2.39034209
12IRAK32.38443524
13FGFR42.27839357
14ERN12.18461453
15ZAP702.12700194
16PRPF4B2.06124263
17TGFBR21.93385169
18CHUK1.77811476
19TNK21.74199834
20BLK1.67864898
21MAP3K131.66968201
22RIPK41.66930831
23TAOK11.61533908
24TEC1.57263973
25STK101.47758879
26FLT31.45160621
27FGFR31.43740059
28NLK1.42954621
29FGR1.42121469
30EPHB11.40317846
31BTK1.39286349
32TAOK31.37426010
33ITK1.35844327
34CSK1.34623480
35MST41.32062387
36RPS6KA41.30289476
37MAP2K31.27236742
38LCK1.26813557
39MAP3K31.25987687
40MAP3K101.23107645
41SYK1.22139485
42PIM11.21023556
43EPHA31.18176420
44PIM21.17042101
45HCK1.15592022
46KDR1.11602167
47JAK21.10988361
48TAOK21.10239488
49CSF1R1.08482438
50TGFBR11.02004612
51RIPK10.99976581
52NME20.97702936
53CDC42BPA0.91338962
54PTK60.85659655
55GRK60.82228744
56CLK10.82150809
57PDK10.80509213
58LYN0.80410981
59TESK20.79361697
60EIF2AK20.74853460
61STK40.72847146
62MARK20.72299148
63NEK90.70237475
64IRAK10.69907411
65PRKD20.69706295
66SIK20.69311804
67LRRK20.67514130
68MARK30.67444173
69IRAK20.65441427
70TIE10.64519265
71FES0.63903452
72YES10.63028029
73ACVR1B0.62797357
74MAPK70.61087934
75CDK60.61039304
76PDPK10.58757107
77TRIB30.58282156
78TTN0.57332150
79MAP2K60.54708851
80FYN0.53427603
81HIPK20.52267704
82KSR20.50325266
83RPS6KA50.49776518
84ABL10.48826697
85MAPK120.48763491
86PDGFRB0.48568890
87CDK120.48434606
88BMPR20.48321393
89PTK2B0.47887611
90PIK3CG0.47548371
91MAP3K70.47458878
92EGFR0.45708196
93GRK70.44469146
94CAMKK20.44150126
95MAPKAPK20.43010037
96RPS6KL10.42826934
97RPS6KC10.42826934
98TLK10.42293037
99DYRK1B0.41722336
100CDK40.41270529
101PKN20.39486636
102PRKCQ0.39446318
103CDK90.39132949
104SGK30.38971371
105MATK0.37529126
106SIK30.37061261
107STK110.36906537
108MAP3K60.35612879
109MAP3K50.35274364
110CAMKK10.35224768
111MAPK150.35222512
112SMG10.34222032
113RPS6KA60.33869723
114PRKCD0.32047250
115STK380.31854221
116PRKG20.31364202
117TRPM70.31180465
118MAP3K20.30901824
119SGK20.30776650
120NUAK10.30472728
121RET0.29447116
122BMX0.29287746
123MAPK40.28854585
124MAP2K20.28722636
125MAPK30.27850321
126MAP3K110.26493145
127STK240.25304785
128MST1R0.25245591
129IGF1R0.24458425
130PBK0.22586946
131ADRBK20.21996065
132SIK10.21835209
133MAP3K10.21497841
134GSK3A0.20977499
135MAPK110.19660389
136ATR0.18233480
137INSR0.17429403

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.03006819
2Leishmaniasis_Homo sapiens_hsa051402.98047630
3Primary immunodeficiency_Homo sapiens_hsa053402.65624385
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.56634733
5Measles_Homo sapiens_hsa051622.55970420
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51358638
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.49550938
8Osteoclast differentiation_Homo sapiens_hsa043802.46420534
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.41989529
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39872933
11Allograft rejection_Homo sapiens_hsa053302.35123281
12Staphylococcus aureus infection_Homo sapiens_hsa051502.28819508
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28385402
14Graft-versus-host disease_Homo sapiens_hsa053322.28226631
15Antigen processing and presentation_Homo sapiens_hsa046122.22644350
16Legionellosis_Homo sapiens_hsa051342.06280201
17Influenza A_Homo sapiens_hsa051642.04471521
18TNF signaling pathway_Homo sapiens_hsa046682.00851624
19Malaria_Homo sapiens_hsa051441.95355997
20Toxoplasmosis_Homo sapiens_hsa051451.92593963
21Herpes simplex infection_Homo sapiens_hsa051681.92587997
22B cell receptor signaling pathway_Homo sapiens_hsa046621.91715090
23* Pertussis_Homo sapiens_hsa051331.87202187
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69935330
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.69612608
26T cell receptor signaling pathway_Homo sapiens_hsa046601.64436975
27Apoptosis_Homo sapiens_hsa042101.56223579
28Tuberculosis_Homo sapiens_hsa051521.52740147
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51554901
30Hematopoietic cell lineage_Homo sapiens_hsa046401.48588789
31African trypanosomiasis_Homo sapiens_hsa051431.41970659
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37656403
33Shigellosis_Homo sapiens_hsa051311.37444557
34Hepatitis B_Homo sapiens_hsa051611.33015061
35* Hepatitis C_Homo sapiens_hsa051601.29000740
36Asthma_Homo sapiens_hsa053101.26452081
37Caffeine metabolism_Homo sapiens_hsa002321.20779442
38Viral myocarditis_Homo sapiens_hsa054161.20215064
39Chemokine signaling pathway_Homo sapiens_hsa040621.19785415
40Rheumatoid arthritis_Homo sapiens_hsa053231.19334943
41Salmonella infection_Homo sapiens_hsa051321.14130270
42Autoimmune thyroid disease_Homo sapiens_hsa053201.13923971
43Acute myeloid leukemia_Homo sapiens_hsa052211.11426926
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.08824413
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07815051
46Other glycan degradation_Homo sapiens_hsa005111.06693303
47Type I diabetes mellitus_Homo sapiens_hsa049401.06554395
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99219439
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.97722956
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94628322
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92913386
52Lysosome_Homo sapiens_hsa041420.88703543
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85356954
54* Prolactin signaling pathway_Homo sapiens_hsa049170.84986612
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84986210
56Small cell lung cancer_Homo sapiens_hsa052220.83653923
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.79850034
58Epstein-Barr virus infection_Homo sapiens_hsa051690.76280998
59Pancreatic cancer_Homo sapiens_hsa052120.68025752
60Platelet activation_Homo sapiens_hsa046110.65123551
61HTLV-I infection_Homo sapiens_hsa051660.65111345
62Dorso-ventral axis formation_Homo sapiens_hsa043200.65099882
63Viral carcinogenesis_Homo sapiens_hsa052030.63865771
64Complement and coagulation cascades_Homo sapiens_hsa046100.60907802
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60527146
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.60002548
67Phagosome_Homo sapiens_hsa041450.58993909
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57379671
69Insulin resistance_Homo sapiens_hsa049310.56991152
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56063124
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55373447
72Amoebiasis_Homo sapiens_hsa051460.53326543
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52260221
74Notch signaling pathway_Homo sapiens_hsa043300.50236984
75ABC transporters_Homo sapiens_hsa020100.49639481
76p53 signaling pathway_Homo sapiens_hsa041150.49403586
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49339567
78Endocytosis_Homo sapiens_hsa041440.45898317
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45486218
80Renal cell carcinoma_Homo sapiens_hsa052110.41405958
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41327728
82MAPK signaling pathway_Homo sapiens_hsa040100.40408410
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.37832384
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35372002
85FoxO signaling pathway_Homo sapiens_hsa040680.34852309
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33880847
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33789890
88Choline metabolism in cancer_Homo sapiens_hsa052310.32371973
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30686938
90Type II diabetes mellitus_Homo sapiens_hsa049300.30230047
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30021565
92Prion diseases_Homo sapiens_hsa050200.30018141
93Prostate cancer_Homo sapiens_hsa052150.29971180
94HIF-1 signaling pathway_Homo sapiens_hsa040660.29850842
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29692608
96MicroRNAs in cancer_Homo sapiens_hsa052060.29544013
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.28935920
98mTOR signaling pathway_Homo sapiens_hsa041500.28439365
99Systemic lupus erythematosus_Homo sapiens_hsa053220.28421132
100GnRH signaling pathway_Homo sapiens_hsa049120.28127375
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27357519
102Non-homologous end-joining_Homo sapiens_hsa034500.26571967
103Regulation of autophagy_Homo sapiens_hsa041400.26424088
104Arachidonic acid metabolism_Homo sapiens_hsa005900.23789838
105Endometrial cancer_Homo sapiens_hsa052130.23479455
106VEGF signaling pathway_Homo sapiens_hsa043700.23073642
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22423071
108Folate biosynthesis_Homo sapiens_hsa007900.21592694
109Inositol phosphate metabolism_Homo sapiens_hsa005620.20032332
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.17928279
111Proteoglycans in cancer_Homo sapiens_hsa052050.17766380
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17735323
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17703157
114Renin-angiotensin system_Homo sapiens_hsa046140.17697562
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16861362
116Pathways in cancer_Homo sapiens_hsa052000.15475442
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14664386
118Adherens junction_Homo sapiens_hsa045200.13255217
119Non-small cell lung cancer_Homo sapiens_hsa052230.12832635
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.12643614
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12342976

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