IRF2BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.08951121
2translational termination (GO:0006415)5.69642007
3translational elongation (GO:0006414)5.06231512
4regulation of mammary gland epithelial cell proliferation (GO:0033599)5.05031102
5ribosomal small subunit assembly (GO:0000028)4.84393413
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.69208045
7viral life cycle (GO:0019058)4.54913664
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.49644514
9ribosomal small subunit biogenesis (GO:0042274)4.47652875
10protein targeting to ER (GO:0045047)4.44018629
11cotranslational protein targeting to membrane (GO:0006613)4.38907577
12negative regulation of erythrocyte differentiation (GO:0045647)4.37095727
13cellular protein complex disassembly (GO:0043624)4.32921196
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.24773908
15apoptotic process involved in morphogenesis (GO:0060561)4.23574683
16protein complex disassembly (GO:0043241)4.21006386
17maternal placenta development (GO:0001893)4.16176646
18translational initiation (GO:0006413)4.11035790
19protein localization to endoplasmic reticulum (GO:0070972)4.06288239
20peptidyl-arginine omega-N-methylation (GO:0035247)4.01460199
21regulation of translational fidelity (GO:0006450)4.01350177
22peptidyl-lysine dimethylation (GO:0018027)3.98578572
23layer formation in cerebral cortex (GO:0021819)3.92623489
24negative regulation of cell size (GO:0045792)3.90157766
25macromolecular complex disassembly (GO:0032984)3.85475353
26negative regulation of RNA splicing (GO:0033119)3.82913215
27DNA unwinding involved in DNA replication (GO:0006268)3.82345793
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.79108720
29adherens junction assembly (GO:0034333)3.76269758
30lymph vessel development (GO:0001945)3.69942783
31positive regulation of histone deacetylation (GO:0031065)3.67261689
32proline biosynthetic process (GO:0006561)3.66762855
33regulation of glucose import in response to insulin stimulus (GO:2001273)3.63867932
34protein localization to endosome (GO:0036010)3.56779825
35activation of Rac GTPase activity (GO:0032863)3.50451035
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.50228222
37Golgi transport vesicle coating (GO:0048200)3.49700651
38COPI coating of Golgi vesicle (GO:0048205)3.49700651
39peptidyl-arginine methylation (GO:0018216)3.41935240
40peptidyl-arginine N-methylation (GO:0035246)3.41935240
41protein-DNA complex disassembly (GO:0032986)3.33486247
42nucleosome disassembly (GO:0006337)3.33486247
43focal adhesion assembly (GO:0048041)3.31864773
44cell-substrate adherens junction assembly (GO:0007045)3.31864773
45spliceosomal tri-snRNP complex assembly (GO:0000244)3.27582092
46negative regulation of glial cell proliferation (GO:0060253)3.27490519
47regulation of NFAT protein import into nucleus (GO:0051532)3.24855694
48locomotory exploration behavior (GO:0035641)3.22283334
49regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.19897943
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.17900162
51positive regulation of RNA splicing (GO:0033120)3.17400372
52epithelial cell fate commitment (GO:0072148)3.15259044
53maturation of SSU-rRNA (GO:0030490)3.14769658
54protein targeting to membrane (GO:0006612)3.13676102
55negative regulation of mRNA processing (GO:0050686)3.12487459
56ncRNA 3-end processing (GO:0043628)3.11631019
57protein retention in ER lumen (GO:0006621)3.08951168
58modulation by virus of host process (GO:0019054)3.08472731
59folic acid-containing compound biosynthetic process (GO:0009396)3.06905899
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04186375
61glucose catabolic process (GO:0006007)3.03396948
623-UTR-mediated mRNA stabilization (GO:0070935)3.03230953
63positive regulation of synapse maturation (GO:0090129)3.03080174
64negative regulation of viral release from host cell (GO:1902187)3.02350662
65glucocorticoid receptor signaling pathway (GO:0042921)3.02155823
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.02040696
67mRNA catabolic process (GO:0006402)3.01614104
68intracellular estrogen receptor signaling pathway (GO:0030520)3.01127749
69activation of MAPKKK activity (GO:0000185)2.98556378
70modulation by symbiont of host cellular process (GO:0044068)2.97641292
71negative regulation of nucleotide catabolic process (GO:0030812)2.95952519
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.95863515
73mammary gland epithelial cell differentiation (GO:0060644)2.94657693
74negative regulation of microtubule polymerization (GO:0031115)2.94175939
75embryonic foregut morphogenesis (GO:0048617)2.93103837
76negative regulation of mRNA metabolic process (GO:1903312)2.93076129
77positive regulation of protein deacetylation (GO:0090312)2.90111369
78histone arginine methylation (GO:0034969)2.89203028
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89093691
80cellular hyperosmotic response (GO:0071474)2.88552202
81RNA catabolic process (GO:0006401)2.86619234
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85731039
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85563972
84regulation of ARF GTPase activity (GO:0032312)2.82796240
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82531320
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82531320
87alternative mRNA splicing, via spliceosome (GO:0000380)2.81384265
88negative regulation of fatty acid transport (GO:2000192)2.79463882
89negative regulation of myotube differentiation (GO:0010832)2.79285663
90embryonic process involved in female pregnancy (GO:0060136)2.78598132
91activation of JUN kinase activity (GO:0007257)2.78242999
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76449744
93cerebellar Purkinje cell layer development (GO:0021680)2.75939993
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.75861160
95epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75495298
96apoptotic process involved in development (GO:1902742)2.75001807
97modulation by virus of host morphology or physiology (GO:0019048)2.74963763
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.74466040
99atrioventricular valve morphogenesis (GO:0003181)2.72934290
100regulation of fatty acid beta-oxidation (GO:0031998)2.72040987
101regulation of early endosome to late endosome transport (GO:2000641)2.69224702
102cardiac muscle cell proliferation (GO:0060038)2.67323613
103positive regulation of nuclease activity (GO:0032075)2.66269765
104positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65321310
105semaphorin-plexin signaling pathway (GO:0071526)2.64639434
106regulation of chromatin binding (GO:0035561)2.62715716
107dosage compensation (GO:0007549)2.61523607
108stress fiber assembly (GO:0043149)2.60308048
109protein targeting to plasma membrane (GO:0072661)2.60037603
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59783464
111outflow tract septum morphogenesis (GO:0003148)2.59749766
112negative regulation of necroptotic process (GO:0060546)2.59699323
113ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.59084521
114synaptic vesicle maturation (GO:0016188)2.58950221
115negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58697633
116DNA deamination (GO:0045006)2.58433886
117basement membrane organization (GO:0071711)2.57322978
118regulation of cholesterol biosynthetic process (GO:0045540)2.57195051
119cell-cell junction maintenance (GO:0045217)2.57148606
120negative regulation of skeletal muscle tissue development (GO:0048642)2.57096614
121cell-substrate junction assembly (GO:0007044)2.55999959
122negative regulation of striated muscle cell differentiation (GO:0051154)2.55742711
123negative regulation of gene expression, epigenetic (GO:0045814)2.54002610
124convergent extension (GO:0060026)2.53984674
125osteoblast development (GO:0002076)2.53806744
126negative regulation of purine nucleotide catabolic process (GO:0033122)2.53626921
127proline metabolic process (GO:0006560)2.53360640
128barbed-end actin filament capping (GO:0051016)2.53251816
129cellular response to virus (GO:0098586)2.52943384
130endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.52661393
131NADPH regeneration (GO:0006740)2.51584950
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51197810
133sodium ion export (GO:0071436)2.50930993
134mannose metabolic process (GO:0006013)2.50885661
135epithelial cell-cell adhesion (GO:0090136)2.50303014
136regulation of protein heterodimerization activity (GO:0043497)2.49251784
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49152432
138regulation of response to osmotic stress (GO:0047484)2.48887756
139mitotic chromosome condensation (GO:0007076)2.48301239
140positive regulation of myotube differentiation (GO:0010831)2.48068179
141megakaryocyte development (GO:0035855)2.47455504
142trophectodermal cell differentiation (GO:0001829)2.45070193
143RNA stabilization (GO:0043489)2.44665331
144mRNA stabilization (GO:0048255)2.44665331
145positive regulation of dendritic spine morphogenesis (GO:0061003)2.44613775
146positive regulation of protein dephosphorylation (GO:0035307)2.44229626
147striated muscle cell proliferation (GO:0014855)2.43832452
148pentose-phosphate shunt (GO:0006098)2.43493224
149dendritic spine morphogenesis (GO:0060997)2.43165964
150activation of protein kinase A activity (GO:0034199)2.42109927
151response to laminar fluid shear stress (GO:0034616)2.42109105
152snRNA metabolic process (GO:0016073)2.41870985
153regulation of translational termination (GO:0006449)2.41292826
154lens morphogenesis in camera-type eye (GO:0002089)2.41004099
155respiratory system process (GO:0003016)2.40862954
156regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.40781689
157regulation of extracellular matrix disassembly (GO:0010715)2.40631744
158positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40597368
159branching involved in mammary gland duct morphogenesis (GO:0060444)2.40117153
160cellular protein complex localization (GO:0034629)2.40067817
161UV protection (GO:0009650)2.38989398
162thymic T cell selection (GO:0045061)2.38484935
163positive regulation of lamellipodium assembly (GO:0010592)2.37928399
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.37839109
165negative regulation of histone acetylation (GO:0035067)2.36822608
166mitotic G1 DNA damage checkpoint (GO:0031571)2.36725285
167positive regulation of transcription regulatory region DNA binding (GO:2000679)2.36454065
168glial cell proliferation (GO:0014009)2.36023660
169regulation of nuclease activity (GO:0032069)2.35950227
170positive regulation of gene expression, epigenetic (GO:0045815)2.35593415
171peptidyl-tyrosine autophosphorylation (GO:0038083)2.35512352
172negative regulation of GTP catabolic process (GO:0033125)2.35344334
173negative regulation of GTPase activity (GO:0034260)2.35344334
174cell migration in hindbrain (GO:0021535)2.35252814
175negative regulation of histone methylation (GO:0031061)2.34862222
176gastrulation with mouth forming second (GO:0001702)2.34548313
177negative regulation of cell killing (GO:0031342)2.34333114
178negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34333114
179positive thymic T cell selection (GO:0045059)2.33270613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.96946737
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24829019
3VDR_21846776_ChIP-Seq_THP-1_Human3.24166399
4E2F7_22180533_ChIP-Seq_HELA_Human2.75564087
5KDM2B_26808549_Chip-Seq_DND41_Human2.69872979
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63953548
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.58311662
8* LXR_22292898_ChIP-Seq_THP-1_Human2.54089013
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50858132
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.44441754
11ZNF263_19887448_ChIP-Seq_K562_Human2.29427949
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27999492
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27835219
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25410656
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.24787395
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23890547
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22255413
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20783371
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20469202
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.07627901
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.05055439
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.97442766
23KDM2B_26808549_Chip-Seq_K562_Human1.83864824
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78072442
25RACK7_27058665_Chip-Seq_MCF-7_Human1.76706868
26VDR_24763502_ChIP-Seq_THP-1_Human1.76546301
27CIITA_25753668_ChIP-Seq_RAJI_Human1.74113266
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68002978
29MAF_26560356_Chip-Seq_TH1_Human1.66913162
30* UTX_26944678_Chip-Seq_JUKART_Human1.66041964
31* CREB1_26743006_Chip-Seq_LNCaP_Human1.63978058
32* SA1_27219007_Chip-Seq_ERYTHROID_Human1.63944867
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60906825
34* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60802303
35* XRN2_22483619_ChIP-Seq_HELA_Human1.60269222
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58584040
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54496894
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.52067743
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50750186
40P68_20966046_ChIP-Seq_HELA_Human1.50030032
41SCL_19346495_ChIP-Seq_HPC-7_Human1.49628226
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49611665
43* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47272069
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46883058
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45718058
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45211194
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45064933
48* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43574684
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42519636
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.41928811
51* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41044620
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40939663
53ATF3_27146783_Chip-Seq_COLON_Human1.36729329
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36234499
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34340841
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34161590
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32859030
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32542353
59MAF_26560356_Chip-Seq_TH2_Human1.32425513
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.32037113
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.28831686
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27381607
63* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23009689
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22650336
65NCOR1_26117541_ChIP-Seq_K562_Human1.20741212
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.20676250
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20573184
68* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19920337
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18125842
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18001909
71* CTCF_21964334_Chip-Seq_Bcells_Human1.17933769
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17138887
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16916086
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16705019
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16606705
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16050354
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15551026
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13243849
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11406631
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10973178
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10059196
82CLOCK_20551151_ChIP-Seq_293T_Human1.08856371
83TP53_22127205_ChIP-Seq_IMR90_Human1.07873920
84* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07318530
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.07188783
86* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06954743
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.06579896
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06483930
89CTCF_27219007_Chip-Seq_Bcells_Human1.04622642
90* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04175908
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04073446
92BCOR_27268052_Chip-Seq_Bcells_Human1.04032785
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.03396891
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02881731
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02818185
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02658587
97PHF8_20622854_ChIP-Seq_HELA_Human1.00825030
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00808649
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00292650
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99985071
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99444077
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99192445
103BCL6_27268052_Chip-Seq_Bcells_Human0.98825018
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98705756
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97975806
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97788540
107CTCF_26484167_Chip-Seq_Bcells_Mouse0.97653273
108SMC4_20622854_ChIP-Seq_HELA_Human0.97648774
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97442538
110* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96597759
111SA1_27219007_Chip-Seq_Bcells_Human0.96545775
112MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96033326
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95861848
114ETS1_21867929_ChIP-Seq_TH2_Mouse0.95019230
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94732293
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94537254
117* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94441758
118GATA1_19941826_ChIP-Seq_K562_Human0.94184470
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.93911186
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.93392366
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93203728
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92237773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.03727827
2MP0009278_abnormal_bone_marrow2.97695303
3MP0003303_peritoneal_inflammation2.87678723
4MP0010030_abnormal_orbit_morphology2.86478083
5MP0008961_abnormal_basal_metabolism2.83963958
6MP0003283_abnormal_digestive_organ2.75366428
7MP0003705_abnormal_hypodermis_morpholog2.70357747
8MP0005058_abnormal_lysosome_morphology2.39433892
9MP0002089_abnormal_postnatal_growth/wei2.32914655
10MP0001346_abnormal_lacrimal_gland2.25966735
11MP0003123_paternal_imprinting2.23933860
12MP0000537_abnormal_urethra_morphology2.23514720
13MP0002234_abnormal_pharynx_morphology2.22113322
14MP0005423_abnormal_somatic_nervous2.21814452
15MP0003300_gastrointestinal_ulcer2.19056081
16MP0004859_abnormal_synaptic_plasticity2.17040499
17MP0002396_abnormal_hematopoietic_system2.09752317
18MP0008260_abnormal_autophagy2.08486166
19MP0005076_abnormal_cell_differentiation2.06557154
20MP0010234_abnormal_vibrissa_follicle2.05795690
21MP0009379_abnormal_foot_pigmentation1.95595392
22MP0009840_abnormal_foam_cell1.92261338
23MP0002249_abnormal_larynx_morphology1.78877123
24MP0006054_spinal_hemorrhage1.77187014
25MP0003122_maternal_imprinting1.74738664
26MP0005397_hematopoietic_system_phenotyp1.73376069
27MP0001545_abnormal_hematopoietic_system1.73376069
28MP0010352_gastrointestinal_tract_polyps1.72934088
29MP0003453_abnormal_keratinocyte_physiol1.71487612
30MP0002877_abnormal_melanocyte_morpholog1.70633646
31MP0004808_abnormal_hematopoietic_stem1.69669263
32MP0008438_abnormal_cutaneous_collagen1.68813264
33MP0002909_abnormal_adrenal_gland1.68164262
34MP0001348_abnormal_lacrimal_gland1.64759309
35MP0005666_abnormal_adipose_tissue1.63081975
36MP0005409_darkened_coat_color1.62973072
37MP0008770_decreased_survivor_rate1.62249650
38MP0003566_abnormal_cell_adhesion1.56939318
39MP0003191_abnormal_cellular_cholesterol1.56201499
40MP0003119_abnormal_digestive_system1.56043420
41MP0001849_ear_inflammation1.54620775
42MP0003091_abnormal_cell_migration1.53540288
43MP0003866_abnormal_defecation1.52896455
44MP0000566_synostosis1.48493882
45MP0000681_abnormal_thyroid_gland1.46131499
46MP0003763_abnormal_thymus_physiology1.44119638
47MP0004233_abnormal_muscle_weight1.44087188
48MP0002653_abnormal_ependyma_morphology1.43961025
49MP0002796_impaired_skin_barrier1.41687873
50MP0000703_abnormal_thymus_morphology1.39883154
51MP0001730_embryonic_growth_arrest1.37592109
52MP0000003_abnormal_adipose_tissue1.37117527
53MP0004858_abnormal_nervous_system1.36116856
54MP0003635_abnormal_synaptic_transmissio1.34533909
55MP0009672_abnormal_birth_weight1.31476750
56MP0004957_abnormal_blastocyst_morpholog1.30333803
57MP0006072_abnormal_retinal_apoptosis1.30162317
58MP0001944_abnormal_pancreas_morphology1.29886713
59MP0000013_abnormal_adipose_tissue1.29804645
60MP0003279_aneurysm1.29750718
61MP0000490_abnormal_crypts_of1.24959676
62MP0000465_gastrointestinal_hemorrhage1.24319035
63MP0009053_abnormal_anal_canal1.23624326
64MP0004197_abnormal_fetal_growth/weight/1.22707618
65MP0002084_abnormal_developmental_patter1.22502559
66MP0003115_abnormal_respiratory_system1.21143855
67MP0000428_abnormal_craniofacial_morphol1.17568870
68MP0000733_abnormal_muscle_development1.16596825
69MP0000747_muscle_weakness1.15504059
70MP0005670_abnormal_white_adipose1.15294427
71MP0001270_distended_abdomen1.14703808
72MP0000462_abnormal_digestive_system1.14659760
73MP0003172_abnormal_lysosome_physiology1.14449252
74MP0002080_prenatal_lethality1.13590080
75MP0008569_lethality_at_weaning1.12754085
76MP0000350_abnormal_cell_proliferation1.11353706
77MP0003111_abnormal_nucleus_morphology1.11291350
78MP0008007_abnormal_cellular_replicative1.11255684
79MP0000751_myopathy1.10887274
80MP0005220_abnormal_exocrine_pancreas1.10414383
81MP0003861_abnormal_nervous_system1.09472648
82MP0004885_abnormal_endolymph1.09452257
83MP0010630_abnormal_cardiac_muscle1.07871946
84MP0000858_altered_metastatic_potential1.06913739
85MP0002085_abnormal_embryonic_tissue1.06009488
86MP0001697_abnormal_embryo_size1.04851718
87MP0000955_abnormal_spinal_cord1.04574987
88MP0000678_abnormal_parathyroid_gland1.02653366
89MP0004510_myositis1.02132201
90MP0004811_abnormal_neuron_physiology1.01909805
91MP0005375_adipose_tissue_phenotype1.00478367
92MP0004381_abnormal_hair_follicle0.99678595
93MP0005621_abnormal_cell_physiology0.98522840
94MP0004272_abnormal_basement_membrane0.98174744
95MP0001784_abnormal_fluid_regulation0.96176275
96MP0000767_abnormal_smooth_muscle0.96057026
97MP0002098_abnormal_vibrissa_morphology0.94739807
98MP0000049_abnormal_middle_ear0.93989308
99MP0003880_abnormal_central_pattern0.93779982
100MP0003385_abnormal_body_wall0.92521856
101MP0003567_abnormal_fetal_cardiomyocyte0.92486510
102MP0002081_perinatal_lethality0.92470016
103MP0002060_abnormal_skin_morphology0.92416080
104MP0000477_abnormal_intestine_morphology0.89709260
105MP0005257_abnormal_intraocular_pressure0.89166280
106MP0000534_abnormal_ureter_morphology0.88939606
107MP0005623_abnormal_meninges_morphology0.88830713
108MP0003329_amyloid_beta_deposits0.88480860
109MP0002086_abnormal_extraembryonic_tissu0.88140204
110MP0000750_abnormal_muscle_regeneration0.88131880
111MP0004947_skin_inflammation0.87576114
112MP0005508_abnormal_skeleton_morphology0.87135371
113MP0000759_abnormal_skeletal_muscle0.85949775
114MP0004185_abnormal_adipocyte_glucose0.85929936
115MP0002152_abnormal_brain_morphology0.85680067
116MP0005501_abnormal_skin_physiology0.84882767
117MP0004264_abnormal_extraembryonic_tissu0.84803736
118MP0003634_abnormal_glial_cell0.83895004
119MP0001502_abnormal_circadian_rhythm0.83688265
120MP0009703_decreased_birth_body0.83346480
121MP0003693_abnormal_embryo_hatching0.82823409
122MP0002092_abnormal_eye_morphology0.82790548
123MP0009931_abnormal_skin_appearance0.82437703
124MP0000467_abnormal_esophagus_morphology0.80202715
125MP0000631_abnormal_neuroendocrine_gland0.78684875
126MP0003935_abnormal_craniofacial_develop0.78592248
127MP0001915_intracranial_hemorrhage0.78183930
128MP0004087_abnormal_muscle_fiber0.76749230
129MP0002398_abnormal_bone_marrow0.76732782
130MP0003315_abnormal_perineum_morphology0.76727941
131MP0005330_cardiomyopathy0.76355550
132MP0003436_decreased_susceptibility_to0.75663149
133MP0002932_abnormal_joint_morphology0.74160843
134MP0002970_abnormal_white_adipose0.73099140
135MP0009333_abnormal_splenocyte_physiolog0.73078084
136MP0003942_abnormal_urinary_system0.72823145
137MP0003984_embryonic_growth_retardation0.72568770
138MP0002088_abnormal_embryonic_growth/wei0.72135793
139MP0001293_anophthalmia0.71393398
140MP0009780_abnormal_chondrocyte_physiolo0.71276746
141MP0002114_abnormal_axial_skeleton0.70823701
142MP0009250_abnormal_appendicular_skeleto0.69971980
143MP0001958_emphysema0.69731464
144MP0000516_abnormal_urinary_system0.66329105
145MP0005367_renal/urinary_system_phenotyp0.66329105
146MP0002822_catalepsy0.66269528
147MP0003077_abnormal_cell_cycle0.65881009
148MP0001340_abnormal_eyelid_morphology0.65205216

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)5.53828767
2Abnormality of cells of the erythroid lineage (HP:0012130)4.45711314
3Abnormal number of erythroid precursors (HP:0012131)4.34912350
4Insomnia (HP:0100785)4.28948997
5Overriding aorta (HP:0002623)3.06413767
6Elfin facies (HP:0004428)3.04664989
7Renal duplication (HP:0000075)3.03758899
8Ankyloglossia (HP:0010296)3.00665595
9Annular pancreas (HP:0001734)2.97169037
10Stridor (HP:0010307)2.90303430
11Broad distal phalanx of finger (HP:0009836)2.78318420
12Hypercortisolism (HP:0001578)2.78010599
13Pointed chin (HP:0000307)2.76133996
14Distal lower limb amyotrophy (HP:0008944)2.75030170
15Increased connective tissue (HP:0009025)2.68935557
16Renovascular hypertension (HP:0100817)2.67053138
17Myopathic facies (HP:0002058)2.65088962
18Genu recurvatum (HP:0002816)2.62547881
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.59047634
20Abnormality of oral frenula (HP:0000190)2.49821235
21Visual hallucinations (HP:0002367)2.48530143
22Cerebral aneurysm (HP:0004944)2.47656481
23Deep palmar crease (HP:0006191)2.45129091
24Vertebral compression fractures (HP:0002953)2.44476038
25Bowel diverticulosis (HP:0005222)2.43878054
26Abnormality of the lower motor neuron (HP:0002366)2.41410342
27Basal cell carcinoma (HP:0002671)2.40499152
28Achilles tendon contracture (HP:0001771)2.40281931
29Distal lower limb muscle weakness (HP:0009053)2.40213482
30Obstructive sleep apnea (HP:0002870)2.35986941
31Abnormality of the distal phalanges of the toes (HP:0010182)2.35500829
32Shallow orbits (HP:0000586)2.32972072
33Increased variability in muscle fiber diameter (HP:0003557)2.31337120
34Macrocytic anemia (HP:0001972)2.25842526
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24576537
36Short 4th metacarpal (HP:0010044)2.24576537
37Neoplasm of the heart (HP:0100544)2.22850282
38Long palpebral fissure (HP:0000637)2.22847674
39Flat cornea (HP:0007720)2.22354474
40Septate vagina (HP:0001153)2.22034289
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.20787547
42Hallux valgus (HP:0001822)2.20457252
43Adducted thumb (HP:0001181)2.20278013
44Premature rupture of membranes (HP:0001788)2.18810791
45Bladder diverticulum (HP:0000015)2.17940248
46Germ cell neoplasia (HP:0100728)2.16840108
47Abnormality of the Achilles tendon (HP:0005109)2.15426668
48Adenoma sebaceum (HP:0009720)2.14063786
49Angiofibromas (HP:0010615)2.14063786
50Increased density of long bones (HP:0006392)2.13591610
51Progressive muscle weakness (HP:0003323)2.11954713
52Abnormality of the fetal cardiovascular system (HP:0010948)2.11952617
53Abnormal umbilical cord blood vessels (HP:0011403)2.11952617
54Single umbilical artery (HP:0001195)2.11952617
55Abnormality of skeletal muscle fiber size (HP:0012084)2.11091077
56Fibroma (HP:0010614)2.10570701
57Deviation of the hallux (HP:0010051)2.09611268
58Abnormality of the phalanges of the hallux (HP:0010057)2.09085128
59Fibrous tissue neoplasm (HP:0012316)2.08538512
60Fragile skin (HP:0001030)2.08341034
61Reticulocytopenia (HP:0001896)2.07246457
62Abnormality of the thoracic spine (HP:0100711)2.07134963
63Abnormality of the umbilical cord (HP:0010881)2.06249836
64Ependymoma (HP:0002888)2.05827749
65Trismus (HP:0000211)2.04810024
66Biconcave vertebral bodies (HP:0004586)2.04792267
67Hyperparathyroidism (HP:0000843)2.04741993
68Abnormality of the aortic arch (HP:0012303)2.04296587
69Truncus arteriosus (HP:0001660)2.04250739
70Mildly elevated creatine phosphokinase (HP:0008180)2.03955816
71Enlarged penis (HP:0000040)2.03188902
72Protrusio acetabuli (HP:0003179)2.02887225
73Precocious puberty (HP:0000826)2.02323238
74Buphthalmos (HP:0000557)2.01527155
75Turricephaly (HP:0000262)2.00866884
76Pallor (HP:0000980)2.00865724
77Increased nuchal translucency (HP:0010880)2.00642296
78Testicular neoplasm (HP:0010788)1.99786789
79Mitral regurgitation (HP:0001653)1.99495730
80Large eyes (HP:0001090)1.98996708
81Short nail (HP:0001799)1.98931078
82Cellulitis (HP:0100658)1.98692115
83Megalencephaly (HP:0001355)1.98228989
84Lower limb amyotrophy (HP:0007210)1.98116271
85Abnormality of the 4th metacarpal (HP:0010012)1.97804649
86Exercise-induced myalgia (HP:0003738)1.97072667
87Macroorchidism (HP:0000053)1.95719442
88Congenital glaucoma (HP:0001087)1.95454120
89Lymphangioma (HP:0100764)1.95083522
90Thin bony cortex (HP:0002753)1.94922779
91Morphological abnormality of the middle ear (HP:0008609)1.94741552
92Ragged-red muscle fibers (HP:0003200)1.93012696
93Bulbar palsy (HP:0001283)1.91672644
94Sacral dimple (HP:0000960)1.91338264
95Ulnar bowing (HP:0003031)1.89600856
96Hypoventilation (HP:0002791)1.89329904
97Ventricular fibrillation (HP:0001663)1.88581025
98Round ear (HP:0100830)1.88135173
99Broad palm (HP:0001169)1.86590341
100Hand muscle atrophy (HP:0009130)1.86559978
101Skin tags (HP:0010609)1.85464733
102Slender long bone (HP:0003100)1.84760134
103Rapidly progressive (HP:0003678)1.84482108
104Dislocated radial head (HP:0003083)1.84153171
105Asymmetry of the thorax (HP:0001555)1.84127303
106Papilloma (HP:0012740)1.83909342
107Verrucae (HP:0200043)1.83909342
108Back pain (HP:0003418)1.83629692
109Bronchomalacia (HP:0002780)1.82932662
110Generalized hypotonia (HP:0001290)1.82573290
111Ankle clonus (HP:0011448)1.82298383
112Upper limb amyotrophy (HP:0009129)1.82108624
113Distal upper limb amyotrophy (HP:0007149)1.82108624
114Limb-girdle muscle atrophy (HP:0003797)1.81920799
115Myokymia (HP:0002411)1.81215671
116Late onset (HP:0003584)1.81067481
117Sporadic (HP:0003745)1.81057265
118Supranuclear gaze palsy (HP:0000605)1.81055861
119Flat acetabular roof (HP:0003180)1.81021240
120Abnormality of the radial head (HP:0003995)1.80887152
121Generalized amyotrophy (HP:0003700)1.80101219
122Growth hormone excess (HP:0000845)1.79927053
123Arnold-Chiari malformation (HP:0002308)1.79217670
124Megalocornea (HP:0000485)1.78229783
125Overlapping toe (HP:0001845)1.78000222
126Thoracic kyphosis (HP:0002942)1.77377716
127Disproportionate tall stature (HP:0001519)1.77187805
128Depression (HP:0000716)1.75176056
129Spinal rigidity (HP:0003306)1.75108923
130J-shaped sella turcica (HP:0002680)1.74723635
131Failure to thrive in infancy (HP:0001531)1.74138700
132Hemorrhage of the eye (HP:0011885)1.73619522
133Thin ribs (HP:0000883)1.73153987
134Rectal prolapse (HP:0002035)1.72548967
135Colon cancer (HP:0003003)1.71323301
136Polycythemia (HP:0001901)1.70830333
137Hemiplegia (HP:0002301)1.70573518
138Broad metatarsal (HP:0001783)1.70478829
139Mesangial abnormality (HP:0001966)1.70205093
140Bowel incontinence (HP:0002607)1.69525017
141Bowed forearm bones (HP:0003956)1.68783657
142Bowing of the arm (HP:0006488)1.68783657
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67930606
144Cerebral inclusion bodies (HP:0100314)1.67872626
145Abnormality of the diencephalon (HP:0010662)1.67329340
146Broad face (HP:0000283)1.67165295
147Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66932515
148Patellar dislocation (HP:0002999)1.66841386
149Abnormal ventriculo-arterial connection (HP:0011563)1.66178704
150Transposition of the great arteries (HP:0001669)1.66178704
151Abnormal connection of the cardiac segments (HP:0011545)1.66178704
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66154055
153Hypercalcemia (HP:0003072)1.65418727
154Pseudobulbar signs (HP:0002200)1.64956592
155Preauricular skin tag (HP:0000384)1.64885647
156Difficulty climbing stairs (HP:0003551)1.64603308
157Abnormality of the fingertips (HP:0001211)1.64599607
158Hyperthyroidism (HP:0000836)1.63532414
159Acanthosis nigricans (HP:0000956)1.63432132
160Cervical subluxation (HP:0003308)1.63290114
161Easy fatigability (HP:0003388)1.63224319
162Cholecystitis (HP:0001082)1.63169305
163Abnormal gallbladder physiology (HP:0012438)1.63169305
164Polygenic inheritance (HP:0010982)1.62567369
165Type 1 muscle fiber predominance (HP:0003803)1.60463374
166Blue sclerae (HP:0000592)1.59881995
167Abnormal large intestine physiology (HP:0012700)1.59398425
168Advanced eruption of teeth (HP:0006288)1.59317350
169Spinal cord compression (HP:0002176)1.59147789
170Premature skin wrinkling (HP:0100678)1.58174954
171Diaphragmatic weakness (HP:0009113)1.58147291
172Aneurysm (HP:0002617)1.57518942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.88439027
2MAP3K104.41345560
3SMG14.13078712
4PKN24.02990971
5EEF2K3.94019008
6PRPF4B3.78815130
7IRAK32.66074971
8CDK122.33681234
9ICK2.00298364
10TAOK11.96846395
11TAOK21.94995619
12PTK61.94012519
13MAP4K11.93055468
14SCYL21.83582653
15LRRK21.75752338
16EPHA21.73536992
17MAP2K31.69316632
18ERN11.66044937
19UHMK11.63498331
20PDGFRA1.62093823
21RIPK11.61147362
22MAP2K21.57275824
23MAP3K111.55782976
24GRK61.50896374
25HIPK21.45924962
26ARAF1.43095979
27ALK1.42576557
28TESK21.28112902
29SIK21.27022190
30MAP3K11.26416010
31KSR21.26355071
32MAP3K91.24732398
33DYRK31.23877119
34PRKD21.22759590
35MAP3K31.17541195
36FGFR41.15538420
37TESK11.14859705
38IRAK21.12856001
39CDK191.11598631
40PAK41.09030254
41FLT31.05535022
42NEK21.03662018
43RPS6KB21.03644970
44CAMKK11.00556012
45PAK20.98275048
46BRAF0.97606586
47MAP3K130.95452674
48CDK40.93453489
49PASK0.93391227
50TYRO30.93318415
51CLK10.92501599
52CDC70.92362272
53PDPK10.88020353
54RPS6KA20.85053871
55RET0.85017750
56MAP3K80.83365276
57MARK20.83005032
58ILK0.82122583
59LATS20.80106496
60BUB10.78488852
61MAP3K70.77735085
62DYRK1B0.76944077
63TLK10.76228739
64CDK70.76198924
65RPS6KA40.73801160
66STK100.73454230
67STK110.73294543
68ZAP700.73129185
69PIM20.72570036
70SIK10.72406916
71MST1R0.71821385
72TNK20.71691938
73CAMK1D0.70975766
74PRKCH0.67134500
75MTOR0.67029326
76FES0.64899351
77PAK60.64885656
78MAPK120.64280734
79CDK60.63942861
80NME20.63587790
81VRK20.63466227
82RPS6KA10.63169567
83RPS6KA60.62150220
84IRAK40.62014425
85PRKD10.61264594
86MATK0.61046200
87TBK10.60553640
88MAPK150.59788506
89RPS6KL10.58076325
90RPS6KC10.58076325
91NTRK30.57775758
92AKT20.56921412
93CDK11A0.56558579
94AURKA0.55296888
95CDK150.54753877
96DAPK10.54660211
97BTK0.54643360
98KDR0.54282266
99CDC42BPA0.52789561
100NTRK20.52264042
101CDK140.51177626
102TTN0.51048352
103MAP3K20.51002141
104PHKG20.50757197
105PHKG10.50757197
106FGFR10.50666475
107BMX0.50110544
108PRKG20.49897392
109PDK10.49861552
110MAPK40.48099179
111KIT0.48089984
112RAF10.47281469
113MAP3K60.46216970
114STK40.44937835
115PTK20.44397338
116MARK10.44016338
117NTRK10.43822800
118EPHB10.43221217
119MAPK90.43038017
120CDK180.42971199
121KSR10.42938587
122CDK90.42467710
123DAPK30.42186636
124CAMK40.41665039
125DDR20.40774821
126MAPK110.40542160
127BRSK10.40450460
128PRKD30.40390492
129CDK80.39096963
130MAPKAPK30.38842725
131TGFBR10.38332733
132LMTK20.38221554
133CDK50.36995399
134EPHB20.30259568
135STK380.29558946
136MOS0.28821675

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.11073769
2Chronic myeloid leukemia_Homo sapiens_hsa052202.07780540
3Notch signaling pathway_Homo sapiens_hsa043301.96655940
4Bladder cancer_Homo sapiens_hsa052191.95091751
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85939806
6Pentose phosphate pathway_Homo sapiens_hsa000301.79254571
7Thyroid cancer_Homo sapiens_hsa052161.73972067
8Other glycan degradation_Homo sapiens_hsa005111.69274135
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61268004
10VEGF signaling pathway_Homo sapiens_hsa043701.60341822
11DNA replication_Homo sapiens_hsa030301.60248487
12Acute myeloid leukemia_Homo sapiens_hsa052211.59097843
13Sulfur relay system_Homo sapiens_hsa041221.56224706
14Spliceosome_Homo sapiens_hsa030401.55675630
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.54667908
16Non-small cell lung cancer_Homo sapiens_hsa052231.52413960
17Glioma_Homo sapiens_hsa052141.50700487
18Estrogen signaling pathway_Homo sapiens_hsa049151.48916133
19Gap junction_Homo sapiens_hsa045401.45944025
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.45396085
21Colorectal cancer_Homo sapiens_hsa052101.40121276
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37188071
23Endometrial cancer_Homo sapiens_hsa052131.36231669
24B cell receptor signaling pathway_Homo sapiens_hsa046621.34444671
25Long-term potentiation_Homo sapiens_hsa047201.29584614
26Cocaine addiction_Homo sapiens_hsa050301.26088710
27Fructose and mannose metabolism_Homo sapiens_hsa000511.25475227
28mTOR signaling pathway_Homo sapiens_hsa041501.24778863
29Biosynthesis of amino acids_Homo sapiens_hsa012301.22803453
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20471869
31Dopaminergic synapse_Homo sapiens_hsa047281.20243217
32Olfactory transduction_Homo sapiens_hsa047401.19938608
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17954828
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16219206
35GnRH signaling pathway_Homo sapiens_hsa049121.15709886
36Gastric acid secretion_Homo sapiens_hsa049711.15231363
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.13982221
38Basal cell carcinoma_Homo sapiens_hsa052171.10507549
39mRNA surveillance pathway_Homo sapiens_hsa030151.10179806
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.09851667
41Melanogenesis_Homo sapiens_hsa049161.09680763
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09326126
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09309561
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07040289
45Hedgehog signaling pathway_Homo sapiens_hsa043401.06478833
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06425089
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05771536
48Renal cell carcinoma_Homo sapiens_hsa052111.05344554
49Amphetamine addiction_Homo sapiens_hsa050311.04799113
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03928471
51Prostate cancer_Homo sapiens_hsa052151.03071890
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02640918
53Vitamin B6 metabolism_Homo sapiens_hsa007501.01923480
54Cholinergic synapse_Homo sapiens_hsa047251.01251222
55Insulin signaling pathway_Homo sapiens_hsa049101.01156438
56N-Glycan biosynthesis_Homo sapiens_hsa005101.00310807
57Base excision repair_Homo sapiens_hsa034101.00219718
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.99467026
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98381539
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97723470
61Galactose metabolism_Homo sapiens_hsa000520.97186486
62Inositol phosphate metabolism_Homo sapiens_hsa005620.96687282
63Alcoholism_Homo sapiens_hsa050340.96363449
64Hepatitis B_Homo sapiens_hsa051610.95927077
65Circadian entrainment_Homo sapiens_hsa047130.94117982
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93981917
67Dorso-ventral axis formation_Homo sapiens_hsa043200.93349928
68Insulin secretion_Homo sapiens_hsa049110.91010404
69Apoptosis_Homo sapiens_hsa042100.90846955
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90563471
71Nitrogen metabolism_Homo sapiens_hsa009100.90552655
72Axon guidance_Homo sapiens_hsa043600.89189146
73MicroRNAs in cancer_Homo sapiens_hsa052060.88387402
74HTLV-I infection_Homo sapiens_hsa051660.88238016
75Oxytocin signaling pathway_Homo sapiens_hsa049210.87834295
76Lysine degradation_Homo sapiens_hsa003100.85960233
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85307556
78ErbB signaling pathway_Homo sapiens_hsa040120.84886387
79Platelet activation_Homo sapiens_hsa046110.84655207
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84562533
81T cell receptor signaling pathway_Homo sapiens_hsa046600.84401709
82Choline metabolism in cancer_Homo sapiens_hsa052310.83213928
83MAPK signaling pathway_Homo sapiens_hsa040100.81839439
84Oocyte meiosis_Homo sapiens_hsa041140.79239009
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78311793
86Renin secretion_Homo sapiens_hsa049240.78259213
87Small cell lung cancer_Homo sapiens_hsa052220.78157759
88Long-term depression_Homo sapiens_hsa047300.78157252
89Proteoglycans in cancer_Homo sapiens_hsa052050.78152652
90Endocytosis_Homo sapiens_hsa041440.77802725
91Hepatitis C_Homo sapiens_hsa051600.77525463
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.75961235
93Wnt signaling pathway_Homo sapiens_hsa043100.75516822
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75511215
95Pancreatic secretion_Homo sapiens_hsa049720.75070291
96Insulin resistance_Homo sapiens_hsa049310.72084783
97Hippo signaling pathway_Homo sapiens_hsa043900.71832128
98Prolactin signaling pathway_Homo sapiens_hsa049170.71573328
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71449414
100Vibrio cholerae infection_Homo sapiens_hsa051100.71173191
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70749339
102One carbon pool by folate_Homo sapiens_hsa006700.70464031
103Glucagon signaling pathway_Homo sapiens_hsa049220.69612952
104Mismatch repair_Homo sapiens_hsa034300.69188255
105Glutamatergic synapse_Homo sapiens_hsa047240.68181836
106Carbon metabolism_Homo sapiens_hsa012000.67480584
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67094492
108Salivary secretion_Homo sapiens_hsa049700.67069318
109Osteoclast differentiation_Homo sapiens_hsa043800.66548031
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65928695
111Type II diabetes mellitus_Homo sapiens_hsa049300.65337825
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.64781954
113Synaptic vesicle cycle_Homo sapiens_hsa047210.64158346
114AMPK signaling pathway_Homo sapiens_hsa041520.63632006
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.63293510
116Focal adhesion_Homo sapiens_hsa045100.62690117
117Rap1 signaling pathway_Homo sapiens_hsa040150.62632397
118HIF-1 signaling pathway_Homo sapiens_hsa040660.62604198
119Melanoma_Homo sapiens_hsa052180.62344719
120Amoebiasis_Homo sapiens_hsa051460.62228222
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62172785
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.61914844
123Pancreatic cancer_Homo sapiens_hsa052120.61815128
124Morphine addiction_Homo sapiens_hsa050320.61781842
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61506330
126Prion diseases_Homo sapiens_hsa050200.61452862
127Viral carcinogenesis_Homo sapiens_hsa052030.61314569
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60202397
129Pathways in cancer_Homo sapiens_hsa052000.60168503
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58954187
131TNF signaling pathway_Homo sapiens_hsa046680.58396910
132Cell cycle_Homo sapiens_hsa041100.58254522
133Toxoplasmosis_Homo sapiens_hsa051450.57523391
134FoxO signaling pathway_Homo sapiens_hsa040680.54749436
135Systemic lupus erythematosus_Homo sapiens_hsa053220.54741561
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51783212
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48997962
138Influenza A_Homo sapiens_hsa051640.48313226
139Shigellosis_Homo sapiens_hsa051310.47554790

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