IRF2BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76798169
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63421688
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.63421688
4positive regulation of granulocyte differentiation (GO:0030854)3.58142672
5negative regulation of granulocyte differentiation (GO:0030853)3.54578019
6tolerance induction (GO:0002507)3.49844279
7positive regulation of histone deacetylation (GO:0031065)3.40979711
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40151592
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.40151592
10modulation by symbiont of host immune response (GO:0052553)3.40151592
11positive regulation by symbiont of host defense response (GO:0052509)3.40151592
12modulation by symbiont of host defense response (GO:0052031)3.40151592
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40151592
14antigen processing and presentation of endogenous antigen (GO:0019883)3.37175485
15negative regulation of cAMP-mediated signaling (GO:0043951)3.33230374
16poly(A)+ mRNA export from nucleus (GO:0016973)3.23459776
17regulation of B cell apoptotic process (GO:0002902)3.22069513
18auditory receptor cell differentiation (GO:0042491)3.20392398
19regulation of interferon-beta biosynthetic process (GO:0045357)3.16372981
20negative regulation of bone resorption (GO:0045779)3.15571142
21positive thymic T cell selection (GO:0045059)3.15309092
22regulation of B cell receptor signaling pathway (GO:0050855)3.14634101
23neutrophil activation involved in immune response (GO:0002283)3.11762320
24definitive hemopoiesis (GO:0060216)3.10949716
25keratinocyte development (GO:0003334)3.09423293
26positive regulation of gamma-delta T cell activation (GO:0046645)3.08600158
27response to muramyl dipeptide (GO:0032495)3.04864010
28cellular extravasation (GO:0045123)3.02020421
29negative regulation of phagocytosis (GO:0050765)2.98860003
30germ cell migration (GO:0008354)2.98124069
31regulation of interleukin-12 biosynthetic process (GO:0045075)2.94091274
32positive regulation of glycolytic process (GO:0045821)2.93958193
33mannose metabolic process (GO:0006013)2.90242348
34cellular response to antibiotic (GO:0071236)2.89802325
35hepatocyte apoptotic process (GO:0097284)2.87672371
36negative regulation of interleukin-8 production (GO:0032717)2.86567046
37negative regulation of bone remodeling (GO:0046851)2.85378805
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85259647
39neutrophil activation (GO:0042119)2.84454692
40gland morphogenesis (GO:0022612)2.82429385
41Rap protein signal transduction (GO:0032486)2.82072020
42negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79919537
43positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79265831
44regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79265831
45growth hormone receptor signaling pathway (GO:0060396)2.78611235
46negative regulation of dendrite morphogenesis (GO:0050774)2.77324387
47ER overload response (GO:0006983)2.75650228
48leukocyte aggregation (GO:0070486)2.75520277
49negative regulation of cell killing (GO:0031342)2.74052187
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74052187
51positive regulation of B cell differentiation (GO:0045579)2.72220924
52endocrine pancreas development (GO:0031018)2.69500492
53sequestering of metal ion (GO:0051238)2.66801301
54regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.66768547
55positive regulation of macrophage differentiation (GO:0045651)2.64975479
56negative regulation of acute inflammatory response (GO:0002674)2.64112096
57macrophage activation involved in immune response (GO:0002281)2.61791438
58pinocytosis (GO:0006907)2.61275093
59skin morphogenesis (GO:0043589)2.60188791
60granulocyte activation (GO:0036230)2.59678344
61positive regulation of DNA-templated transcription, initiation (GO:2000144)2.58918287
62interkinetic nuclear migration (GO:0022027)2.58543053
63regulation of B cell differentiation (GO:0045577)2.58429115
64negative regulation of humoral immune response (GO:0002921)2.57739467
65neutrophil mediated immunity (GO:0002446)2.55775010
66negative regulation of B cell proliferation (GO:0030889)2.53981154
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.53313496
68eye photoreceptor cell differentiation (GO:0001754)2.52839347
69photoreceptor cell differentiation (GO:0046530)2.52839347
70response to xenobiotic stimulus (GO:0009410)2.52834161
71negative regulation of fatty acid transport (GO:2000192)2.52664073
72negative regulation of protein oligomerization (GO:0032460)2.51919668
73histone H3-K36 demethylation (GO:0070544)2.51349539
74cytoplasmic mRNA processing body assembly (GO:0033962)2.50747095
75regulation of gamma-delta T cell differentiation (GO:0045586)2.49943495
76parental behavior (GO:0060746)2.49325081
77response to laminar fluid shear stress (GO:0034616)2.48953830
78L-fucose catabolic process (GO:0042355)2.48747806
79fucose catabolic process (GO:0019317)2.48747806
80L-fucose metabolic process (GO:0042354)2.48747806
81positive T cell selection (GO:0043368)2.47917608
82cellular response to ethanol (GO:0071361)2.46931008
83regulation of hexokinase activity (GO:1903299)2.45576271
84regulation of glucokinase activity (GO:0033131)2.45576271
85negative regulation of complement activation (GO:0045916)2.45408337
86regulation of germinal center formation (GO:0002634)2.42712643
87negative regulation of tissue remodeling (GO:0034104)2.42579785
88positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.41733833
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40462655
90megakaryocyte development (GO:0035855)2.39706409
91cellular response to toxic substance (GO:0097237)2.39586396
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38758462
93heparin metabolic process (GO:0030202)2.38667518
94heparin biosynthetic process (GO:0030210)2.38667518
95histone H3-K4 trimethylation (GO:0080182)2.38576610
96positive regulation of glycogen biosynthetic process (GO:0045725)2.38488021
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38043678
98cellular response to growth hormone stimulus (GO:0071378)2.37572407
99regulation of mRNA catabolic process (GO:0061013)2.37151844
100positive regulation of p38MAPK cascade (GO:1900745)2.35700669
101response to peptidoglycan (GO:0032494)2.34042904
102positive regulation of mRNA catabolic process (GO:0061014)2.33796610
103positive regulation of Rap GTPase activity (GO:0032854)2.33742962
104regulation of gamma-delta T cell activation (GO:0046643)2.33427134
105B cell homeostasis (GO:0001782)2.32908739
106positive regulation of protein deacetylation (GO:0090312)2.32655801
107negative regulation of protein activation cascade (GO:2000258)2.32417880
108regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.32366923
109regulation of erythrocyte differentiation (GO:0045646)2.31914639
110negative thymic T cell selection (GO:0045060)2.29426560
111B cell receptor signaling pathway (GO:0050853)2.29184744
112response to fungus (GO:0009620)2.28535743
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.27806090
114positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.27806090
115apoptotic cell clearance (GO:0043277)2.25667481
116microglial cell activation (GO:0001774)2.25590450
117interleukin-1-mediated signaling pathway (GO:0070498)2.24558672
118toxin transport (GO:1901998)2.24462866
119interferon-gamma production (GO:0032609)2.24170862
120respiratory burst (GO:0045730)2.23512687
121histone demethylation (GO:0016577)2.23499477
122protein K11-linked deubiquitination (GO:0035871)2.22143869
123regulation of granulocyte differentiation (GO:0030852)2.21718397
124G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.20712791
125thymic T cell selection (GO:0045061)2.20105574
126negative regulation of protein autophosphorylation (GO:0031953)2.19567948
127negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.19538953
128regulation of type B pancreatic cell apoptotic process (GO:2000674)2.18206616
129type B pancreatic cell development (GO:0003323)2.17193123
130positive regulation of extracellular matrix organization (GO:1903055)2.17126821
131cellular response to exogenous dsRNA (GO:0071360)2.16468328
132positive regulation of chemokine secretion (GO:0090197)2.16138373
133embryonic camera-type eye morphogenesis (GO:0048596)2.15972191
134negative regulation of erythrocyte differentiation (GO:0045647)2.15581260
135negative regulation of growth of symbiont in host (GO:0044130)2.15457783
136negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.15457783
137modulation of growth of symbiont involved in interaction with host (GO:0044144)2.15457783
138regulation of growth of symbiont in host (GO:0044126)2.15457783
139germinal center formation (GO:0002467)2.15452711
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.14331873
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.13370907
142myeloid cell activation involved in immune response (GO:0002275)2.13353047
143regulation of histone H3-K27 methylation (GO:0061085)2.13215290
144T-helper 1 type immune response (GO:0042088)2.12583738
145negative regulation of neurotransmitter secretion (GO:0046929)2.12178645
146early endosome to late endosome transport (GO:0045022)2.12177858
147histamine secretion (GO:0001821)2.11769702
148regulation of chemokine secretion (GO:0090196)2.11653874
149regulation of respiratory burst (GO:0060263)2.11558605
150defense response to fungus (GO:0050832)2.11275988
151positive regulation by host of viral transcription (GO:0043923)2.11203394
152regulation of T cell tolerance induction (GO:0002664)2.10804389
153response to lipoprotein particle (GO:0055094)2.09441724
154antigen processing and presentation via MHC class Ib (GO:0002475)2.09427895
155angiogenesis involved in wound healing (GO:0060055)2.08635757
156T cell selection (GO:0045058)2.08357794
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.08095061
158glandular epithelial cell development (GO:0002068)2.07984683
159positive regulation of antigen processing and presentation (GO:0002579)2.07888711
160exocrine pancreas development (GO:0031017)2.07740848
161negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.07722108
162negative regulation of T-helper cell differentiation (GO:0045623)2.07722108
163cellular response to fluid shear stress (GO:0071498)2.07695335
164cell wall macromolecule catabolic process (GO:0016998)2.07643474
165positive regulation of glycogen metabolic process (GO:0070875)2.07596094
166histone lysine demethylation (GO:0070076)2.06990566
167hyaluronan catabolic process (GO:0030214)2.06362480
168macrophage activation (GO:0042116)2.06059155
169regulation of glycolytic process (GO:0006110)2.05700977
170response to fluid shear stress (GO:0034405)2.05561139
171regulation of histone deacetylation (GO:0031063)2.05054270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.61290683
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.10273907
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.96967039
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58953965
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.44264371
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43237725
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.19207727
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.06945910
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01867402
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.82465406
11SCL_19346495_ChIP-Seq_HPC-7_Human2.80914127
12GATA1_22025678_ChIP-Seq_K562_Human2.75560910
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73664590
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70580825
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67578305
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65219809
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.63827298
18RUNX_20019798_ChIP-Seq_JUKART_Human2.38641073
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30870435
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23922028
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22215735
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10559389
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.08617339
24* VDR_21846776_ChIP-Seq_THP-1_Human2.05182447
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04189255
26* VDR_24763502_ChIP-Seq_THP-1_Human2.02057142
27* MYB_26560356_Chip-Seq_TH2_Human1.94824973
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.91365245
29* MYC_22102868_ChIP-Seq_BL_Human1.81716072
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79923581
31* MAF_26560356_Chip-Seq_TH1_Human1.78413635
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74229392
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71066265
34* MYB_26560356_Chip-Seq_TH1_Human1.63561776
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.63015746
36SPI1_23127762_ChIP-Seq_K562_Human1.61875293
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.61174241
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61160759
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.60884011
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60115818
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57700813
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56980284
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54229424
44* UTX_26944678_Chip-Seq_JUKART_Human1.53427268
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53122356
46PU_27001747_Chip-Seq_BMDM_Mouse1.52861357
47* VDR_24787735_ChIP-Seq_THP-1_Human1.50384594
48* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46745947
49CLOCK_20551151_ChIP-Seq_293T_Human1.45633328
50* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45465370
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44757449
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42832679
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.41714638
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41383279
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40933261
56SPI1_23547873_ChIP-Seq_NB4_Human1.40818023
57* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37851594
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37462029
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36924350
60* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35644010
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34906119
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32765280
63AHR_22903824_ChIP-Seq_MCF-7_Human1.32572511
64* KDM2B_26808549_Chip-Seq_DND41_Human1.32159305
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30932623
66* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30658257
67* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28824826
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27710723
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.27211018
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27061136
71* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26987520
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26608845
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26587234
74* GATA3_27048872_Chip-Seq_THYMUS_Human1.25875795
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24555348
76ER_23166858_ChIP-Seq_MCF-7_Human1.20064770
77* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19029100
78* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19029100
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18591376
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18277567
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18229509
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18098834
83* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17797848
84GATA1_19941826_ChIP-Seq_K562_Human1.17610955
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.17315526
86* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16956788
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16431533
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.14967681
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.14468813
90* RXR_22158963_ChIP-Seq_LIVER_Mouse1.13183812
91* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12413179
92* GATA2_19941826_ChIP-Seq_K562_Human1.12045120
93* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11340820
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11170042
95* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11084771
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10922805
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10749302
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10265333
99* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09630954
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08937238
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08515287
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.07986102
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07877909
104* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07476972
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06474202
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05696302
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05312379
108GATA3_26560356_Chip-Seq_TH2_Human1.04759987
109BRD4_25478319_ChIP-Seq_HGPS_Human1.04582320
110* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04563425
111* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03439936
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.03345444
113RXR_22108803_ChIP-Seq_LS180_Human1.03109654
114* CJUN_26792858_Chip-Seq_BT549_Human1.02310684
115* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02263506
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02038947
117* CDX2_20551321_ChIP-Seq_CACO-2_Human1.01166285
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99567423
119* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99100566
120* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98953801
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96955903
122* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96359768
123* LXR_22158963_ChIP-Seq_LIVER_Mouse0.96042894
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95951060
125* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95490752
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.94240986
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.94225160
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91714653
129* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91169113
130* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91098520
131* GATA6_25053715_ChIP-Seq_YYC3_Human0.91094604
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90028866
133* NCOR1_26117541_ChIP-Seq_K562_Human0.89902008
134CDX2_22108803_ChIP-Seq_LS180_Human0.88664645
135SOX2_20726797_ChIP-Seq_SW620_Human0.86558331
136* SMRT_27268052_Chip-Seq_Bcells_Human0.86150370
137* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84748834
138* GATA4_25053715_ChIP-Seq_YYC3_Human0.84658156
139* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84425941
140VDR_22108803_ChIP-Seq_LS180_Human0.84198630
141* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82810080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.61237878
2MP0003303_peritoneal_inflammation2.66521385
3MP0002166_altered_tumor_susceptibility2.56559456
4MP0008057_abnormal_DNA_replication2.46104876
5MP0002877_abnormal_melanocyte_morpholog2.35007228
6MP0003436_decreased_susceptibility_to2.33040325
7MP0001835_abnormal_antigen_presentation2.18778023
8MP0003656_abnormal_erythrocyte_physiolo2.07179156
9MP0003724_increased_susceptibility_to2.03428430
10MP0005076_abnormal_cell_differentiation1.99469237
11MP0002396_abnormal_hematopoietic_system1.98376722
12MP0001790_abnormal_immune_system1.91103524
13MP0005387_immune_system_phenotype1.91103524
14MP0005058_abnormal_lysosome_morphology1.89608556
15MP0000465_gastrointestinal_hemorrhage1.87708878
16MP0006054_spinal_hemorrhage1.85152688
17MP0002419_abnormal_innate_immunity1.85119386
18MP0003943_abnormal_hepatobiliary_system1.83284508
19MP0003183_abnormal_peptide_metabolism1.82765154
20MP0002006_tumorigenesis1.81764472
21MP0005000_abnormal_immune_tolerance1.81484793
22MP0001800_abnormal_humoral_immune1.74261549
23MP0002009_preneoplasia1.73650700
24MP0001851_eye_inflammation1.72917429
25MP0000685_abnormal_immune_system1.71203740
26MP0002452_abnormal_antigen_presenting1.68947573
27MP0010352_gastrointestinal_tract_polyps1.68812871
28MP0004947_skin_inflammation1.67046874
29MP0001533_abnormal_skeleton_physiology1.63306870
30MP0003566_abnormal_cell_adhesion1.60670340
31MP0008438_abnormal_cutaneous_collagen1.60433115
32MP0005464_abnormal_platelet_physiology1.59787038
33MP0003828_pulmonary_edema1.57545090
34MP0002405_respiratory_system_inflammati1.57398312
35MP0002723_abnormal_immune_serum1.56241881
36MP0003045_fibrosis1.56201222
37MP0009278_abnormal_bone_marrow1.55138821
38MP0004808_abnormal_hematopoietic_stem1.52948600
39MP0002420_abnormal_adaptive_immunity1.52732376
40MP0003763_abnormal_thymus_physiology1.51495243
41MP0001819_abnormal_immune_cell1.50538336
42MP0003195_calcinosis1.50387122
43MP0005025_abnormal_response_to1.48137684
44MP0002148_abnormal_hypersensitivity_rea1.48042417
45MP0010234_abnormal_vibrissa_follicle1.46613938
46MP0005671_abnormal_response_to1.45012454
47MP0002933_joint_inflammation1.43156917
48MP0002998_abnormal_bone_remodeling1.42493491
49MP0010155_abnormal_intestine_physiology1.41122268
50MP0003172_abnormal_lysosome_physiology1.38961645
51MP0002132_abnormal_respiratory_system1.38758303
52MP0003252_abnormal_bile_duct1.37854101
53MP0005379_endocrine/exocrine_gland_phen1.37738713
54MP0004782_abnormal_surfactant_physiolog1.37570441
55MP0002060_abnormal_skin_morphology1.36792147
56MP0000013_abnormal_adipose_tissue1.36582973
57MP0000516_abnormal_urinary_system1.34843129
58MP0005367_renal/urinary_system_phenotyp1.34843129
59MP0003453_abnormal_keratinocyte_physiol1.31899719
60MP0010329_abnormal_lipoprotein_level1.30553692
61MP0001853_heart_inflammation1.30398842
62MP0005645_abnormal_hypothalamus_physiol1.29823811
63MP0003191_abnormal_cellular_cholesterol1.26992650
64MP0001845_abnormal_inflammatory_respons1.26532590
65MP0002928_abnormal_bile_duct1.23358299
66MP0001873_stomach_inflammation1.22884202
67MP0002398_abnormal_bone_marrow1.20454684
68MP0004510_myositis1.19782333
69MP0003866_abnormal_defecation1.19684991
70MP0000716_abnormal_immune_system1.19590714
71MP0005275_abnormal_skin_tensile1.18820500
72MP0005397_hematopoietic_system_phenotyp1.18809828
73MP0001545_abnormal_hematopoietic_system1.18809828
74MP0002139_abnormal_hepatobiliary_system1.17191940
75MP0004381_abnormal_hair_follicle1.14905361
76MP0002138_abnormal_hepatobiliary_system1.12561252
77MP0005174_abnormal_tail_pigmentation1.12416708
78MP0000569_abnormal_digit_pigmentation1.10787810
79MP0004484_altered_response_of1.08925031
80MP0004264_abnormal_extraembryonic_tissu1.08718409
81MP0003705_abnormal_hypodermis_morpholog1.08149063
82MP0002693_abnormal_pancreas_physiology1.08110525
83MP0009785_altered_susceptibility_to1.07474205
84MP0005670_abnormal_white_adipose1.06119315
85MP0003795_abnormal_bone_structure1.05904674
86MP0001756_abnormal_urination1.05598307
87MP0005390_skeleton_phenotype1.05523567
88MP0005023_abnormal_wound_healing1.05441506
89MP0009115_abnormal_fat_cell1.04367400
90MP0004185_abnormal_adipocyte_glucose1.03405945
91MP0000343_altered_response_to1.01610636
92MP0010678_abnormal_skin_adnexa1.00744487
93MP0001270_distended_abdomen1.00348292
94MP0002876_abnormal_thyroid_physiology0.99757873
95MP0000681_abnormal_thyroid_gland0.99722637
96MP0002722_abnormal_immune_system0.98541267
97MP0000689_abnormal_spleen_morphology0.98311534
98MP0000703_abnormal_thymus_morphology0.97519798
99MP0003279_aneurysm0.96623059
100MP0005646_abnormal_pituitary_gland0.96441677
101MP0002896_abnormal_bone_mineralization0.96397758
102MP0005365_abnormal_bile_salt0.96384382
103MP0001765_abnormal_ion_homeostasis0.96009727
104MP0001216_abnormal_epidermal_layer0.95144600
105MP0000858_altered_metastatic_potential0.94172945
106MP0000383_abnormal_hair_follicle0.93719247
107MP0003448_altered_tumor_morphology0.93533251
108MP0002429_abnormal_blood_cell0.93299895
109MP0010307_abnormal_tumor_latency0.92843615
110MP0005257_abnormal_intraocular_pressure0.92440398
111MP0000490_abnormal_crypts_of0.91934015
112MP0000609_abnormal_liver_physiology0.91494263
113MP0005310_abnormal_salivary_gland0.91167466
114MP0001944_abnormal_pancreas_morphology0.90602673
115MP0001501_abnormal_sleep_pattern0.88737234
116MP0008961_abnormal_basal_metabolism0.88417320
117MP0000767_abnormal_smooth_muscle0.86554041
118MP0005220_abnormal_exocrine_pancreas0.86218263
119MP0001879_abnormal_lymphatic_vessel0.86127628
120MP0009931_abnormal_skin_appearance0.85962047
121MP0001502_abnormal_circadian_rhythm0.85721286
122MP0000003_abnormal_adipose_tissue0.84783959
123MP0009333_abnormal_splenocyte_physiolog0.84171687
124MP0001958_emphysema0.82769311
125MP0002078_abnormal_glucose_homeostasis0.81964972
126MP0008995_early_reproductive_senescence0.81885675
127MP0000377_abnormal_hair_follicle0.81457825
128MP0002971_abnormal_brown_adipose0.81260308
129MP0008469_abnormal_protein_level0.80362134
130MP0002098_abnormal_vibrissa_morphology0.79772402
131MP0001764_abnormal_homeostasis0.79164176
132MP0000598_abnormal_liver_morphology0.78848321
133MP0009643_abnormal_urine_homeostasis0.78833944
134MP0001243_abnormal_dermal_layer0.78414466
135MP0005375_adipose_tissue_phenotype0.78367766
136MP0002168_other_aberrant_phenotype0.78186060
137MP0009780_abnormal_chondrocyte_physiolo0.77934264
138MP0002163_abnormal_gland_morphology0.77051296

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.21211221
2Recurrent abscess formation (HP:0002722)3.75491402
3Recurrent bacterial skin infections (HP:0005406)3.74564967
4Large for gestational age (HP:0001520)3.18213903
5Hematochezia (HP:0002573)3.11022986
6Dysostosis multiplex (HP:0000943)3.04595404
7Testicular neoplasm (HP:0010788)3.01694604
8Sex reversal (HP:0012245)2.99522985
9Abnormal sex determination (HP:0012244)2.99522985
10Widely spaced teeth (HP:0000687)2.98209844
11Cerebral aneurysm (HP:0004944)2.91173354
12Abnormality of the fingertips (HP:0001211)2.86925523
13Periodontitis (HP:0000704)2.85289759
14Urinary glycosaminoglycan excretion (HP:0003541)2.83717937
15Mucopolysacchariduria (HP:0008155)2.83717937
16Recurrent fungal infections (HP:0002841)2.83217886
17Spondylolisthesis (HP:0003302)2.79108680
18Acute lymphatic leukemia (HP:0006721)2.73118731
19Hyperglycemia (HP:0003074)2.72299162
20Hypothermia (HP:0002045)2.69422927
21Hamartoma of the eye (HP:0010568)2.65060448
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.65049458
23Osteolytic defects of the hand bones (HP:0009699)2.65049458
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60813321
25Abnormality of polysaccharide metabolism (HP:0011012)2.60813321
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60813321
27Macroorchidism (HP:0000053)2.60258800
28Vacuolated lymphocytes (HP:0001922)2.58520839
29Germ cell neoplasia (HP:0100728)2.55371033
30Spontaneous hematomas (HP:0007420)2.55036398
31Cellulitis (HP:0100658)2.51238901
32Recurrent skin infections (HP:0001581)2.50313342
33Ketoacidosis (HP:0001993)2.48962070
34Interstitial pulmonary disease (HP:0006530)2.47958599
35Increased CSF protein (HP:0002922)2.47891568
36Inflammation of the large intestine (HP:0002037)2.47218929
37Hyperinsulinemic hypoglycemia (HP:0000825)2.44724099
38Gingivitis (HP:0000230)2.44222810
39Exocrine pancreatic insufficiency (HP:0001738)2.42047115
40Metaphyseal dysplasia (HP:0100255)2.40718115
41Lip pit (HP:0100267)2.40432181
42IgM deficiency (HP:0002850)2.38303248
43Recurrent gram-negative bacterial infections (HP:0005420)2.37708125
44Recurrent viral infections (HP:0004429)2.36181676
45Fair hair (HP:0002286)2.35789772
46Myocardial infarction (HP:0001658)2.34874202
47Abnormality of endocrine pancreas physiology (HP:0012093)2.33437440
48Abnormality of the pancreatic islet cells (HP:0006476)2.33437440
49Neoplasm of the tracheobronchial system (HP:0100552)2.32551945
50Malnutrition (HP:0004395)2.32088955
51Aortic aneurysm (HP:0004942)2.31786957
52Febrile seizures (HP:0002373)2.30360817
53Alveolar cell carcinoma (HP:0006519)2.27095280
54Gastrointestinal inflammation (HP:0004386)2.25203739
55Hyperkalemia (HP:0002153)2.24167996
56Abnormality of the nasal septum (HP:0000419)2.23522912
57Enlarged penis (HP:0000040)2.21257712
58Symptomatic seizures (HP:0011145)2.21056333
59Chronic otitis media (HP:0000389)2.19693251
60Conjunctival hamartoma (HP:0100780)2.19670643
61Myositis (HP:0100614)2.19243125
62Colitis (HP:0002583)2.19124345
63Hypoglycemic coma (HP:0001325)2.17731948
64Abnormality of macrophages (HP:0004311)2.17350767
65Hypochromic anemia (HP:0001931)2.16832479
66Generalized hypopigmentation of hair (HP:0011358)2.16415201
67Disproportionate tall stature (HP:0001519)2.16344199
68Amyloidosis (HP:0011034)2.14817953
69Chronic mucocutaneous candidiasis (HP:0002728)2.14427005
70Recurrent cutaneous fungal infections (HP:0011370)2.14427005
71Syringomyelia (HP:0003396)2.14163076
72Spinal cord lesions (HP:0100561)2.14163076
73Increased IgE level (HP:0003212)2.13829985
74Gingival bleeding (HP:0000225)2.13257590
75Mediastinal lymphadenopathy (HP:0100721)2.11966357
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.11686998
77Osteomyelitis (HP:0002754)2.10026032
78Mitral valve prolapse (HP:0001634)2.09774617
79Meningitis (HP:0001287)2.06894980
80Curly hair (HP:0002212)2.04654490
81Stomach cancer (HP:0012126)2.04410155
82Milia (HP:0001056)2.04018429
83Prolonged bleeding time (HP:0003010)2.02180081
84Atrophic scars (HP:0001075)2.00064880
85Arterial thrombosis (HP:0004420)1.99291124
86Pustule (HP:0200039)1.99194803
87Obstructive lung disease (HP:0006536)1.99031292
88Chronic obstructive pulmonary disease (HP:0006510)1.99031292
89Disinhibition (HP:0000734)1.98771431
90Thin bony cortex (HP:0002753)1.98676970
91Persistence of primary teeth (HP:0006335)1.96741681
92Acute myeloid leukemia (HP:0004808)1.95722091
93Systemic lupus erythematosus (HP:0002725)1.91781540
94Aortic dissection (HP:0002647)1.91313775
95Viral hepatitis (HP:0006562)1.90206280
96Abnormal platelet function (HP:0011869)1.89706951
97Impaired platelet aggregation (HP:0003540)1.89706951
98Hemoptysis (HP:0002105)1.89662046
99Thick nail (HP:0001805)1.89448134
100Elevated erythrocyte sedimentation rate (HP:0003565)1.88810927
101Neoplasm of the adrenal cortex (HP:0100641)1.87019237
102Cervical subluxation (HP:0003308)1.85660101
103Pulmonary infiltrates (HP:0002113)1.85488637
104Abnormality of secondary sexual hair (HP:0009888)1.85285483
105Abnormality of the axillary hair (HP:0100134)1.85285483
106Septate vagina (HP:0001153)1.84593056
107Menstrual irregularities (HP:0000858)1.84437549
108Narrow palate (HP:0000189)1.83882147
109Hypochromic microcytic anemia (HP:0004840)1.83479621
110Submucous cleft hard palate (HP:0000176)1.83187308
111Increased cerebral lipofuscin (HP:0011813)1.83148995
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83112049
113Alopecia of scalp (HP:0002293)1.82823975
114Asymmetry of the thorax (HP:0001555)1.82358107
115Tubulointerstitial nephritis (HP:0001970)1.82051688
116Epistaxis (HP:0000421)1.81025715
117Stomatitis (HP:0010280)1.80519446
118Abnormality of the renal cortex (HP:0011035)1.79882431
119Gonadal dysgenesis (HP:0000133)1.79367042
120Ketosis (HP:0001946)1.78462710
121Neoplasm of the lung (HP:0100526)1.77809604
122Autoimmune hemolytic anemia (HP:0001890)1.77312066
123Vasculitis (HP:0002633)1.77064794
124Sepsis (HP:0100806)1.77032331
125Coarse hair (HP:0002208)1.77028443
126Subacute progressive viral hepatitis (HP:0006572)1.76997846
127Abnormality of the prostate (HP:0008775)1.76186010
128T lymphocytopenia (HP:0005403)1.76166152
129Hamartoma (HP:0010566)1.75325403
130Pigmentary retinal degeneration (HP:0001146)1.74858034
131Cheilitis (HP:0100825)1.74550176
132Broad face (HP:0000283)1.73924300
133Absent frontal sinuses (HP:0002688)1.73918484
134Increased density of long bones (HP:0006392)1.73018214
135Episodic fever (HP:0001954)1.72929098
136Chronic diarrhea (HP:0002028)1.72519537
137Thyroiditis (HP:0100646)1.72128784
138Visceral angiomatosis (HP:0100761)1.71761477
139Decreased circulating renin level (HP:0003351)1.71645001
140Arterial tortuosity (HP:0005116)1.71621383
141Abnormality of T cell physiology (HP:0011840)1.70816049
142Hypokalemic alkalosis (HP:0001949)1.70779552
143Craniofacial hyperostosis (HP:0004493)1.70475350
144Shallow orbits (HP:0000586)1.70289736
145Glomerulonephritis (HP:0000099)1.70266527
146Fragile skin (HP:0001030)1.69590635
147Abnormality of transition element cation homeostasis (HP:0011030)1.69561922
148Eosinophilia (HP:0001880)1.69415381
149Thickened calvaria (HP:0002684)1.68532818
150Bone pain (HP:0002653)1.68069333
151Insulin-resistant diabetes mellitus (HP:0000831)1.67401129
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.67357303
153Gastrointestinal infarctions (HP:0005244)1.66636274
154Pancreatic islet-cell hyperplasia (HP:0004510)1.66623341
155Abnormality of small intestinal villus morphology (HP:0011472)1.64985124
156Villous atrophy (HP:0011473)1.64985124
157Mitral stenosis (HP:0001718)1.64973071
158Generalized hyperpigmentation (HP:0007440)1.64761078
159Orchitis (HP:0100796)1.64125542
160Thrombocytosis (HP:0001894)1.62734925
161Abnormality of the frontal sinuses (HP:0002687)1.60857246
162Peritonitis (HP:0002586)1.60733592
163Chest pain (HP:0100749)1.60507078
164Hypoglycemic seizures (HP:0002173)1.60139719
165Abnormal platelet volume (HP:0011876)1.59418662
166Urethral obstruction (HP:0000796)1.59286297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK32.55908813
2TGFBR22.50734791
3MAP4K12.45154785
4EPHB12.32219362
5MAPK152.27773957
6AKT32.23718205
7MAP3K102.22580569
8TRIB32.02639482
9FRK1.99646118
10IRAK41.92464134
11ERN11.92188877
12INSRR1.88386382
13HIPK21.79247654
14PRPF4B1.77647437
15DMPK1.73801370
16STK101.73210022
17IRAK31.69841572
18ITK1.69811301
19FLT31.62163589
20TEC1.61239589
21JAK11.57895496
22CAMK1D1.57225881
23TYK21.57222267
24FGFR31.56428681
25BRSK21.55988336
26SIK11.54363885
27PTK61.52207453
28PKN21.52204595
29EPHA31.48480308
30MAP3K141.46804152
31EEF2K1.46769676
32KIT1.44053979
33RIPK11.41707138
34FER1.40634879
35JAK31.39881512
36BRD41.36020640
37ZAP701.35430313
38CAMK1G1.31646912
39CHUK1.31117442
40BTK1.29770122
41CDK61.29679870
42CSF1R1.25463481
43SGK21.24023700
44YES11.23556237
45FGFR41.21430943
46TBK11.20483120
47LRRK21.19398502
48TRPM71.16515659
49FGFR21.15693399
50CDK121.15060778
51TXK1.14869727
52IKBKB1.14670745
53CSK1.13723081
54IRAK21.12844848
55MAP3K131.10588083
56IKBKE1.10148354
57BMPR21.06659456
58MAP2K21.02775094
59MAP3K71.01012381
60PIM11.00325251
61LATS11.00308930
62NEK90.99375674
63TNK20.96638585
64PDGFRB0.96592802
65TTN0.95328384
66NLK0.93942783
67SMG10.93242284
68MAPK70.93241662
69PASK0.93036184
70NUAK10.92470519
71HCK0.91302348
72MAP2K30.89662121
73MAPKAPK30.87947524
74BLK0.87632745
75CLK10.86498649
76JAK20.85652897
77GRK60.84549735
78MAP2K60.84281675
79STK30.84258323
80RPS6KB20.83864706
81LCK0.83582049
82SIK30.83522154
83DYRK1B0.82524793
84RPS6KA40.82145814
85CDK90.81040119
86PDGFRA0.77958626
87CDK30.74824595
88MAPK110.73972938
89EIF2AK30.72538215
90SYK0.70287500
91MAPK120.69905426
92RPS6KA60.69648425
93DAPK20.68689191
94GSK3A0.68631117
95MAPKAPK20.67789443
96TAOK10.67554030
97IRAK10.67374672
98RPS6KL10.66976995
99RPS6KC10.66976995
100MKNK20.66800403
101MARK30.65465445
102STK240.65230830
103PNCK0.64678379
104PRKD10.63407239
105SGK4940.63155825
106SGK2230.63155825
107SGK30.62089774
108MST40.60006649
109MAP3K30.59945238
110PINK10.58230923
111WEE10.58164592
112RIPK40.57760647
113MAPKAPK50.57382662
114RPS6KA50.57298570
115MAP3K20.56555549
116PDK10.56185609
117LYN0.56110960
118SCYL20.53742374
119MELK0.53623378
120PIM20.52890337
121ERBB30.52470485
122PIK3CG0.52222549
123MTOR0.51917167
124SIK20.51128774
125RPS6KB10.50472738
126PRKD20.50210049
127MAP4K20.49988217
128CAMK40.48745678
129MAPK40.48630443
130PAK40.48248381
131PAK20.48156454
132STK40.48147063
133RPS6KA20.47485668
134FES0.46501383
135PRKAA20.46203957
136GRK10.44084379
137PRKCQ0.43956408
138PIK3CA0.43832318
139MAP3K10.42985459
140STK390.41696865

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.32514067
2Osteoclast differentiation_Homo sapiens_hsa043802.29257315
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.21959093
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.09013669
5Type I diabetes mellitus_Homo sapiens_hsa049401.95980796
6B cell receptor signaling pathway_Homo sapiens_hsa046621.92685770
7Staphylococcus aureus infection_Homo sapiens_hsa051501.76705780
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.75768479
9Toxoplasmosis_Homo sapiens_hsa051451.70767407
10Other glycan degradation_Homo sapiens_hsa005111.64693404
11Chronic myeloid leukemia_Homo sapiens_hsa052201.62312406
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61572409
13Circadian rhythm_Homo sapiens_hsa047101.58339276
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53926952
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.50514542
16Antigen processing and presentation_Homo sapiens_hsa046121.48021584
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46913561
18Hematopoietic cell lineage_Homo sapiens_hsa046401.45770664
19Lysosome_Homo sapiens_hsa041421.42949397
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41873389
21Acute myeloid leukemia_Homo sapiens_hsa052211.41699705
22Primary immunodeficiency_Homo sapiens_hsa053401.39654300
23Allograft rejection_Homo sapiens_hsa053301.39317211
24Measles_Homo sapiens_hsa051621.39094407
25mTOR signaling pathway_Homo sapiens_hsa041501.38840124
26Pancreatic cancer_Homo sapiens_hsa052121.34190886
27Tuberculosis_Homo sapiens_hsa051521.33335288
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.30656592
29Pertussis_Homo sapiens_hsa051331.29947044
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29386052
31Small cell lung cancer_Homo sapiens_hsa052221.28948372
32Autoimmune thyroid disease_Homo sapiens_hsa053201.24468410
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22986837
34TNF signaling pathway_Homo sapiens_hsa046681.22771705
35T cell receptor signaling pathway_Homo sapiens_hsa046601.22769797
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.22185684
37Platelet activation_Homo sapiens_hsa046111.21205585
38Prostate cancer_Homo sapiens_hsa052151.20445515
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19819400
40Hepatitis B_Homo sapiens_hsa051611.15552832
41Chemokine signaling pathway_Homo sapiens_hsa040621.14723139
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13105072
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12286942
44Lysine degradation_Homo sapiens_hsa003101.11421523
45Insulin resistance_Homo sapiens_hsa049311.07565081
46Apoptosis_Homo sapiens_hsa042101.06554232
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05549898
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04555458
49Renin secretion_Homo sapiens_hsa049241.03869430
50Graft-versus-host disease_Homo sapiens_hsa053321.03839170
51Adherens junction_Homo sapiens_hsa045201.03794134
52Malaria_Homo sapiens_hsa051441.03252233
53Amoebiasis_Homo sapiens_hsa051461.01875962
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01673063
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00960362
56Nitrogen metabolism_Homo sapiens_hsa009100.99890375
57Focal adhesion_Homo sapiens_hsa045100.99793706
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99788948
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99541449
60Legionellosis_Homo sapiens_hsa051340.98767847
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98338231
62Proteoglycans in cancer_Homo sapiens_hsa052050.97403967
63MicroRNAs in cancer_Homo sapiens_hsa052060.97389090
64Influenza A_Homo sapiens_hsa051640.95949946
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94972514
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94779674
67Prolactin signaling pathway_Homo sapiens_hsa049170.94397700
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93480931
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93152920
70ECM-receptor interaction_Homo sapiens_hsa045120.92029464
71Non-small cell lung cancer_Homo sapiens_hsa052230.91396693
72Viral carcinogenesis_Homo sapiens_hsa052030.90933094
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90741938
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.89596273
75ABC transporters_Homo sapiens_hsa020100.87847688
76Inositol phosphate metabolism_Homo sapiens_hsa005620.86335905
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84476244
78Herpes simplex infection_Homo sapiens_hsa051680.81485997
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81216692
80FoxO signaling pathway_Homo sapiens_hsa040680.81078903
81Notch signaling pathway_Homo sapiens_hsa043300.80678201
82Ether lipid metabolism_Homo sapiens_hsa005650.80242016
83Choline metabolism in cancer_Homo sapiens_hsa052310.80213760
84Type II diabetes mellitus_Homo sapiens_hsa049300.79994011
85GnRH signaling pathway_Homo sapiens_hsa049120.79309489
86Hepatitis C_Homo sapiens_hsa051600.79158316
87Viral myocarditis_Homo sapiens_hsa054160.77653937
88Glucagon signaling pathway_Homo sapiens_hsa049220.77346405
89Salmonella infection_Homo sapiens_hsa051320.76599185
90Endometrial cancer_Homo sapiens_hsa052130.74354293
91Insulin secretion_Homo sapiens_hsa049110.72020001
92Estrogen signaling pathway_Homo sapiens_hsa049150.71721582
93Renal cell carcinoma_Homo sapiens_hsa052110.71159666
94Colorectal cancer_Homo sapiens_hsa052100.71109969
95Regulation of autophagy_Homo sapiens_hsa041400.70115265
96Shigellosis_Homo sapiens_hsa051310.69280311
97Asthma_Homo sapiens_hsa053100.69083460
98HTLV-I infection_Homo sapiens_hsa051660.68393463
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66629378
100Pathways in cancer_Homo sapiens_hsa052000.66188747
101Thyroid cancer_Homo sapiens_hsa052160.66180332
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66077623
103Thyroid hormone synthesis_Homo sapiens_hsa049180.65723846
104VEGF signaling pathway_Homo sapiens_hsa043700.65189452
105Caffeine metabolism_Homo sapiens_hsa002320.64781415
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64065913
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63838843
108Linoleic acid metabolism_Homo sapiens_hsa005910.63030357
109Sulfur metabolism_Homo sapiens_hsa009200.62877036
110AMPK signaling pathway_Homo sapiens_hsa041520.62050740
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61982415
112Phagosome_Homo sapiens_hsa041450.61838162
113Renin-angiotensin system_Homo sapiens_hsa046140.61484830
114Systemic lupus erythematosus_Homo sapiens_hsa053220.61390742
115Dorso-ventral axis formation_Homo sapiens_hsa043200.60610803
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60101982
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59879736
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.59657010
119MAPK signaling pathway_Homo sapiens_hsa040100.59497328
120Sphingolipid metabolism_Homo sapiens_hsa006000.57951340
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.57825921
122Bladder cancer_Homo sapiens_hsa052190.57117693
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.56796417
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56007559
125Pancreatic secretion_Homo sapiens_hsa049720.55651513
126Ovarian steroidogenesis_Homo sapiens_hsa049130.54478943
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54246047
128Complement and coagulation cascades_Homo sapiens_hsa046100.53879063
129Salivary secretion_Homo sapiens_hsa049700.52538046
130Long-term depression_Homo sapiens_hsa047300.52414446
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50611615
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49711782
133Glioma_Homo sapiens_hsa052140.49646048
134N-Glycan biosynthesis_Homo sapiens_hsa005100.48541617
135Protein export_Homo sapiens_hsa030600.48523495
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.47029536
137Mineral absorption_Homo sapiens_hsa049780.46568140
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46216009
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45600278
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43656285

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