IRF2BPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that may play a role in regulating female reproductive function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.14599754
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.60048601
3membrane repolarization during action potential (GO:0086011)5.55908669
4cellular potassium ion homeostasis (GO:0030007)4.79776651
5regulation of cell proliferation involved in kidney development (GO:1901722)4.23565488
6regulation of mesoderm development (GO:2000380)4.07594865
7cell migration in hindbrain (GO:0021535)4.05058918
8regulation of membrane repolarization (GO:0060306)4.03244658
9membrane repolarization (GO:0086009)3.91230951
10cell proliferation in forebrain (GO:0021846)3.87200781
11layer formation in cerebral cortex (GO:0021819)3.80900287
12regulation of glomerulus development (GO:0090192)3.78513169
13positive regulation of potassium ion transmembrane transport (GO:1901381)3.61559286
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.60505552
15ovulation cycle (GO:0042698)3.57006022
16somite development (GO:0061053)3.55109897
17establishment of apical/basal cell polarity (GO:0035089)3.53452142
18magnesium ion transport (GO:0015693)3.51360396
19cellular anion homeostasis (GO:0030002)3.51031777
20interferon-gamma secretion (GO:0072643)3.47362803
21establishment of monopolar cell polarity (GO:0061162)3.43617603
22establishment or maintenance of monopolar cell polarity (GO:0061339)3.43617603
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.42497665
24regulation of hippo signaling (GO:0035330)3.38198212
25polarized epithelial cell differentiation (GO:0030859)3.37122099
26negative regulation of catenin import into nucleus (GO:0035414)3.36889912
27lateral sprouting from an epithelium (GO:0060601)3.33308877
28negative regulation of embryonic development (GO:0045992)3.29416494
29spinal cord development (GO:0021510)3.29296970
30fat-soluble vitamin catabolic process (GO:0042363)3.26965940
31vitamin catabolic process (GO:0009111)3.26965940
32behavioral response to nicotine (GO:0035095)3.24043531
33positive regulation of fatty acid oxidation (GO:0046321)3.23538522
34regulation of skeletal muscle contraction (GO:0014819)3.22901043
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21823132
36epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.07425815
37epithelial cell-cell adhesion (GO:0090136)3.07065986
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01746151
39epithelial cell maturation (GO:0002070)3.00638453
40regulation of potassium ion transmembrane transport (GO:1901379)2.98586575
41potassium ion import (GO:0010107)2.96232842
42DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95359504
43regulation of synapse structural plasticity (GO:0051823)2.94754392
44white fat cell differentiation (GO:0050872)2.93732882
45pharyngeal system development (GO:0060037)2.93514862
46hippo signaling (GO:0035329)2.93480132
47dendritic spine morphogenesis (GO:0060997)2.93119957
48negative regulation of axon extension involved in axon guidance (GO:0048843)2.91258530
49cell-cell junction maintenance (GO:0045217)2.89891131
50positive regulation of cardiac muscle cell differentiation (GO:2000727)2.88004642
51middle ear morphogenesis (GO:0042474)2.87794458
52cell junction maintenance (GO:0034331)2.87640124
53endoderm formation (GO:0001706)2.86686679
54lung morphogenesis (GO:0060425)2.86600884
55mesonephros development (GO:0001823)2.86433461
56adherens junction assembly (GO:0034333)2.83878266
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83557586
58positive regulation of glomerulus development (GO:0090193)2.83402059
59regulation of synapse maturation (GO:0090128)2.83060725
60cell-cell signaling involved in cell fate commitment (GO:0045168)2.82986974
61positive regulation of transcription regulatory region DNA binding (GO:2000679)2.82373323
62cardiovascular system development (GO:0072358)2.80529412
63positive regulation of synapse maturation (GO:0090129)2.80522118
64phosphate ion homeostasis (GO:0055062)2.79874269
65trivalent inorganic anion homeostasis (GO:0072506)2.79874269
66glial cell proliferation (GO:0014009)2.78910993
67developmental induction (GO:0031128)2.78614686
68positive regulation of metanephros development (GO:0072216)2.77620139
69aorta morphogenesis (GO:0035909)2.76817217
70renal system development (GO:0072001)2.75554828
71plasma membrane repair (GO:0001778)2.75398825
72glandular epithelial cell differentiation (GO:0002067)2.75272591
73regulation of heart rate by cardiac conduction (GO:0086091)2.74845881
74negative regulation of systemic arterial blood pressure (GO:0003085)2.73642909
75negative regulation of protein localization to cell surface (GO:2000009)2.69789151
76stress fiber assembly (GO:0043149)2.67325400
77axon extension (GO:0048675)2.66101038
78pattern specification involved in kidney development (GO:0061004)2.66044791
79signal complex assembly (GO:0007172)2.65640975
80peripheral nervous system axon ensheathment (GO:0032292)2.64724752
81myelination in peripheral nervous system (GO:0022011)2.64724752
82protein localization to endosome (GO:0036010)2.63708081
83epithelial cell fate commitment (GO:0072148)2.63456806
84otic vesicle formation (GO:0030916)2.62034165
85cell migration involved in sprouting angiogenesis (GO:0002042)2.61505204
86tooth mineralization (GO:0034505)2.61200730
87establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58865768
88anterior/posterior axis specification, embryo (GO:0008595)2.58100640
89protein heterotrimerization (GO:0070208)2.57301929
90positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57164535
91sulfation (GO:0051923)2.57088042
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.57067193
93regulation of fatty acid beta-oxidation (GO:0031998)2.56562101
94ectodermal placode formation (GO:0060788)2.56240081
95embryonic process involved in female pregnancy (GO:0060136)2.55445673
96negative regulation of Ras GTPase activity (GO:0034261)2.55303825
97endothelial cell chemotaxis (GO:0035767)2.54806446
98potassium ion homeostasis (GO:0055075)2.54609516
99regulation of SMAD protein import into nucleus (GO:0060390)2.53929526
100regulation of posttranscriptional gene silencing (GO:0060147)2.53162135
101regulation of gene silencing by miRNA (GO:0060964)2.53162135
102regulation of gene silencing by RNA (GO:0060966)2.53162135
103relaxation of cardiac muscle (GO:0055119)2.52249113
104respiratory system process (GO:0003016)2.51800891
105apoptotic process involved in morphogenesis (GO:0060561)2.51102487
106respiratory tube development (GO:0030323)2.51006306
107retinal ganglion cell axon guidance (GO:0031290)2.50061559
108cardiac conduction (GO:0061337)2.49941521
109artery development (GO:0060840)2.49053506
110hemidesmosome assembly (GO:0031581)2.48215531
111establishment of nucleus localization (GO:0040023)2.48198480
112ear development (GO:0043583)2.47968771
113cellular response to electrical stimulus (GO:0071257)2.47714836
114pituitary gland development (GO:0021983)2.47492767
115sodium ion export (GO:0071436)2.46741473
116prostate gland epithelium morphogenesis (GO:0060740)2.46340860
117regulation of axon extension involved in axon guidance (GO:0048841)2.46169984
118postsynaptic membrane organization (GO:0001941)2.46043460
119negative regulation of cell size (GO:0045792)2.46024249
120embryonic hindlimb morphogenesis (GO:0035116)2.45790325
121regulation of organ formation (GO:0003156)2.45458791
122trophectodermal cell differentiation (GO:0001829)2.45108188
123organ induction (GO:0001759)2.44883321
124focal adhesion assembly (GO:0048041)2.44879789
125cell-substrate adherens junction assembly (GO:0007045)2.44879789
126positive regulation of triglyceride biosynthetic process (GO:0010867)2.44753786
127positive regulation of SMAD protein import into nucleus (GO:0060391)2.44691782
128DNA damage response, signal transduction resulting in transcription (GO:0042772)2.44680322
129dermatan sulfate biosynthetic process (GO:0030208)2.44391626
130regulation of tight junction assembly (GO:2000810)2.43389503
131cell-substrate junction assembly (GO:0007044)2.42686113
132gastrulation with mouth forming second (GO:0001702)2.42498354
133embryonic skeletal joint morphogenesis (GO:0060272)2.42297005
134positive regulation of axon extension (GO:0045773)2.42173245
135water-soluble vitamin biosynthetic process (GO:0042364)2.41993784
136response to electrical stimulus (GO:0051602)2.41620376
137multicellular organismal signaling (GO:0035637)2.41583700
138endocardial cushion development (GO:0003197)2.41435186
139segment specification (GO:0007379)2.41114030
140dorsal/ventral axis specification (GO:0009950)2.40885239
141negative regulation of glycogen biosynthetic process (GO:0045719)2.40861293
142dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.40787730
143negative regulation of glial cell proliferation (GO:0060253)2.40751146
144proline transport (GO:0015824)2.40711618
145vocalization behavior (GO:0071625)2.39418630
146convergent extension (GO:0060026)2.39115384
147stress granule assembly (GO:0034063)2.38894668
148adherens junction organization (GO:0034332)2.38372963
149dendrite morphogenesis (GO:0048813)2.38014596
150negative regulation of microtubule polymerization (GO:0031115)2.37904052
151embryonic camera-type eye development (GO:0031076)2.37394145
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.36932324
153axonal fasciculation (GO:0007413)2.36731911
154negative regulation of chondrocyte differentiation (GO:0032331)2.36499847
155regulation of early endosome to late endosome transport (GO:2000641)2.36430856
156regulation of catenin import into nucleus (GO:0035412)2.35696659
157synaptic vesicle maturation (GO:0016188)2.34156864
158regulation of p38MAPK cascade (GO:1900744)2.33434302
159growth hormone secretion (GO:0030252)2.33408615
160neuron projection extension (GO:1990138)2.33097394
161embryonic foregut morphogenesis (GO:0048617)2.32847949
162innervation (GO:0060384)2.31670188
163cell communication by electrical coupling (GO:0010644)2.28873650
164positive regulation of histone deacetylation (GO:0031065)2.28423001
165cerebellar Purkinje cell layer development (GO:0021680)2.26882553
166establishment or maintenance of apical/basal cell polarity (GO:0035088)2.26570418
167establishment or maintenance of bipolar cell polarity (GO:0061245)2.26570418
168regulation of NFAT protein import into nucleus (GO:0051532)2.26541192
169locomotory exploration behavior (GO:0035641)2.25016780
170positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24133360
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.23729566
172collecting duct development (GO:0072044)2.23248931
173negative regulation of fatty acid transport (GO:2000192)2.22416700
174lung-associated mesenchyme development (GO:0060484)2.22014819
175establishment of epithelial cell polarity (GO:0090162)2.21415561
176negative regulation of cartilage development (GO:0061037)2.21150960
177forebrain neuron differentiation (GO:0021879)2.20748067
178central nervous system projection neuron axonogenesis (GO:0021952)2.20597156
179apoptotic process involved in development (GO:1902742)2.18612814
180camera-type eye morphogenesis (GO:0048593)2.18169431
181developmental cell growth (GO:0048588)2.17612853
182dendritic spine organization (GO:0097061)2.17327694
183myoblast fusion (GO:0007520)2.15898232
184negative regulation of potassium ion transmembrane transport (GO:1901380)2.15551971
185neural tube closure (GO:0001843)2.14961539
186neuron recognition (GO:0008038)2.13645446
187establishment of cell polarity (GO:0030010)2.13626979
188negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.13489787
189paraxial mesoderm development (GO:0048339)2.13431885
190epithelial cell differentiation involved in prostate gland development (GO:0060742)2.12792602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25749124
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.87006273
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78889122
4ZFP281_18757296_ChIP-ChIP_E14_Mouse2.72042613
5ZNF263_19887448_ChIP-Seq_K562_Human2.62002661
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.59909546
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.57761674
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.48754392
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44710235
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44710235
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44710235
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.37986560
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.34129387
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.33599436
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32638730
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.30172775
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29584021
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28838184
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25287885
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22744483
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18325865
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.18071018
23KDM2B_26808549_Chip-Seq_K562_Human2.13761091
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09984165
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09426897
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09354435
27KDM2B_26808549_Chip-Seq_DND41_Human1.96065170
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92901088
29EZH2_22144423_ChIP-Seq_EOC_Human1.87780031
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81278012
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80209331
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.78114651
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.73362612
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72150266
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.70828220
36CLOCK_20551151_ChIP-Seq_293T_Human1.70766640
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69653300
38LXR_22292898_ChIP-Seq_THP-1_Human1.67892118
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65579324
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65443414
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65443414
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65079641
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62465491
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61717563
45RNF2_27304074_Chip-Seq_NSC_Mouse1.57376358
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56292550
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55218550
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.54685522
49MYC_22102868_ChIP-Seq_BL_Human1.51571295
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.50913631
51RACK7_27058665_Chip-Seq_MCF-7_Human1.49853190
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49475689
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.47490393
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.47376799
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44955843
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44672035
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.44654599
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43877517
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43855565
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42499908
61REST_21632747_ChIP-Seq_MESCs_Mouse1.42262142
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42176621
63CREB1_26743006_Chip-Seq_LNCaP_Human1.41340991
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40743066
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39920410
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39519097
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35518198
68TCF7_22412390_ChIP-Seq_EML_Mouse1.35261548
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33921358
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32958474
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.32526910
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32346679
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.31023597
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.30984196
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29744835
76PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29452313
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.29219095
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28402828
79DROSHA_22980978_ChIP-Seq_HELA_Human1.27900577
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26992943
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26458203
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26404145
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25577860
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25279787
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22475093
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22393214
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.21814517
88CTCF_27219007_Chip-Seq_Bcells_Human1.21776295
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.21542346
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19991193
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19179582
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.19084686
93TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17047477
94AHR_22903824_ChIP-Seq_MCF-7_Human1.16831244
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16606669
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16421174
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16392224
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.15151844
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13845173
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.12943070
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12638438
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.12160959
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11791464
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11600275
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11234369
106ATF3_27146783_Chip-Seq_COLON_Human1.11228230
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09078252
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08122327
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08038150
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07124110
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07062527
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05837057
113PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05720520
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04524837
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01134550
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.00750283
117SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00431164
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00071736
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99482416
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.98726033
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97561767
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97494127
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95373037
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.95187071
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.93485802
126AR_21572438_ChIP-Seq_LNCaP_Human0.91719404
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91195162
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90395633
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86580917
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.82993308
131TP53_22127205_ChIP-Seq_IMR90_Human0.82388961
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82373640
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80288756
134GBX2_23144817_ChIP-Seq_PC3_Human0.79346833
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78949311
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78949311
137AR_19668381_ChIP-Seq_PC3_Human0.78692682
138RXR_22108803_ChIP-Seq_LS180_Human0.78344511
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74817905
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74391677
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73968138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.19605024
2MP0003283_abnormal_digestive_organ3.13701287
3MP0010030_abnormal_orbit_morphology2.96420860
4MP0005623_abnormal_meninges_morphology2.70434984
5MP0002653_abnormal_ependyma_morphology2.45037613
6MP0003705_abnormal_hypodermis_morpholog2.43083376
7MP0000537_abnormal_urethra_morphology2.39655074
8MP0010234_abnormal_vibrissa_follicle2.29050714
9MP0004858_abnormal_nervous_system2.23821629
10MP0002089_abnormal_postnatal_growth/wei2.13155974
11MP0009250_abnormal_appendicular_skeleto2.12636108
12MP0003119_abnormal_digestive_system2.11158704
13MP0004859_abnormal_synaptic_plasticity2.07022319
14MP0002160_abnormal_reproductive_system2.04530909
15MP0005076_abnormal_cell_differentiation2.03647929
16MP0002837_dystrophic_cardiac_calcinosis1.99103233
17MP0001849_ear_inflammation1.92896074
18MP0009384_cardiac_valve_regurgitation1.92420415
19MP0001485_abnormal_pinna_reflex1.90899495
20MP0004130_abnormal_muscle_cell1.89511403
21MP0005646_abnormal_pituitary_gland1.89170401
22MP0008961_abnormal_basal_metabolism1.88154042
23MP0003938_abnormal_ear_development1.87188682
24MP0000631_abnormal_neuroendocrine_gland1.83036758
25MP0003879_abnormal_hair_cell1.76406457
26MP0001542_abnormal_bone_strength1.69112386
27MP0000516_abnormal_urinary_system1.68575207
28MP0005367_renal/urinary_system_phenotyp1.68575207
29MP0000534_abnormal_ureter_morphology1.68464024
30MP0001440_abnormal_grooming_behavior1.67040729
31MP0004133_heterotaxia1.66818271
32MP0003136_yellow_coat_color1.66495532
33MP0000778_abnormal_nervous_system1.64554742
34MP0004145_abnormal_muscle_electrophysio1.60631131
35MP0003566_abnormal_cell_adhesion1.59813868
36MP0001968_abnormal_touch/_nociception1.59248230
37MP0005248_abnormal_Harderian_gland1.57909298
38MP0010352_gastrointestinal_tract_polyps1.56674195
39MP0004272_abnormal_basement_membrane1.54799400
40MP0003937_abnormal_limbs/digits/tail_de1.54031946
41MP0005389_reproductive_system_phenotype1.51986696
42MP0004233_abnormal_muscle_weight1.51473129
43MP0005394_taste/olfaction_phenotype1.51178084
44MP0005499_abnormal_olfactory_system1.51178084
45MP0002736_abnormal_nociception_after1.50245444
46MP0002234_abnormal_pharynx_morphology1.49924563
47MP0002909_abnormal_adrenal_gland1.49773683
48MP0008789_abnormal_olfactory_epithelium1.48559897
49MP0003942_abnormal_urinary_system1.43283753
50MP0004134_abnormal_chest_morphology1.40131915
51MP0000733_abnormal_muscle_development1.39538384
52MP0009053_abnormal_anal_canal1.39431916
53MP0009379_abnormal_foot_pigmentation1.39084664
54MP0000026_abnormal_inner_ear1.37505269
55MP0003279_aneurysm1.37363030
56MP0003755_abnormal_palate_morphology1.37195486
57MP0002249_abnormal_larynx_morphology1.36579659
58MP0000751_myopathy1.35818115
59MP0003091_abnormal_cell_migration1.35531894
60MP0002877_abnormal_melanocyte_morpholog1.33836362
61MP0003646_muscle_fatigue1.31725852
62MP0005503_abnormal_tendon_morphology1.30620128
63MP0003385_abnormal_body_wall1.30265272
64MP0009278_abnormal_bone_marrow1.30017733
65MP0001919_abnormal_reproductive_system1.29193532
66MP0002272_abnormal_nervous_system1.28883133
67MP0002084_abnormal_developmental_patter1.28309719
68MP0008438_abnormal_cutaneous_collagen1.26656336
69MP0002282_abnormal_trachea_morphology1.26632683
70MP0003861_abnormal_nervous_system1.24198132
71MP0001502_abnormal_circadian_rhythm1.22656018
72MP0002184_abnormal_innervation1.21320468
73MP0005275_abnormal_skin_tensile1.18640725
74MP0003635_abnormal_synaptic_transmissio1.18478026
75MP0002116_abnormal_craniofacial_bone1.17782680
76MP0003935_abnormal_craniofacial_develop1.17749751
77MP0003115_abnormal_respiratory_system1.17685297
78MP0003122_maternal_imprinting1.16793999
79MP0003123_paternal_imprinting1.16170591
80MP0002876_abnormal_thyroid_physiology1.14313975
81MP0002277_abnormal_respiratory_mucosa1.13977110
82MP0000678_abnormal_parathyroid_gland1.12239509
83MP0000750_abnormal_muscle_regeneration1.11371582
84MP0004142_abnormal_muscle_tone1.11280067
85MP0004885_abnormal_endolymph1.11052307
86MP0002085_abnormal_embryonic_tissue1.10734716
87MP0004742_abnormal_vestibular_system1.09865891
88MP0009780_abnormal_chondrocyte_physiolo1.08505210
89MP0003045_fibrosis1.08261266
90MP0000762_abnormal_tongue_morphology1.07498693
91MP0000428_abnormal_craniofacial_morphol1.07338388
92MP0005508_abnormal_skeleton_morphology1.05333785
93MP0000467_abnormal_esophagus_morphology1.05229821
94MP0003890_abnormal_embryonic-extraembry1.03373144
95MP0004811_abnormal_neuron_physiology1.02838390
96MP0002063_abnormal_learning/memory/cond1.02627090
97MP0003567_abnormal_fetal_cardiomyocyte1.02266404
98MP0000049_abnormal_middle_ear1.01184993
99MP0002925_abnormal_cardiovascular_devel1.01046270
100MP0002233_abnormal_nose_morphology1.00909511
101MP0000003_abnormal_adipose_tissue1.00907054
102MP0000163_abnormal_cartilage_morphology1.00657148
103MP0002697_abnormal_eye_size1.00635126
104MP0000613_abnormal_salivary_gland1.00318795
105MP0002896_abnormal_bone_mineralization0.99799009
106MP0002735_abnormal_chemical_nociception0.99768181
107MP0006072_abnormal_retinal_apoptosis0.98217888
108MP0003011_delayed_dark_adaptation0.98209975
109MP0004084_abnormal_cardiac_muscle0.98208503
110MP0009745_abnormal_behavioral_response0.96438322
111MP0004197_abnormal_fetal_growth/weight/0.95286605
112MP0000955_abnormal_spinal_cord0.93922414
113MP0003878_abnormal_ear_physiology0.93313552
114MP0005377_hearing/vestibular/ear_phenot0.93313552
115MP0001348_abnormal_lacrimal_gland0.93215394
116MP0002733_abnormal_thermal_nociception0.93041504
117MP0002751_abnormal_autonomic_nervous0.92993867
118MP0001963_abnormal_hearing_physiology0.92834108
119MP0005423_abnormal_somatic_nervous0.92387032
120MP0002734_abnormal_mechanical_nocicepti0.92283783
121MP0004270_analgesia0.91907751
122MP0000566_synostosis0.91616071
123MP0002138_abnormal_hepatobiliary_system0.90678017
124MP0002081_perinatal_lethality0.90623731
125MP0000432_abnormal_head_morphology0.90574804
126MP0002064_seizures0.89210587
127MP0002152_abnormal_brain_morphology0.88832604
128MP0003315_abnormal_perineum_morphology0.88196711
129MP0003941_abnormal_skin_development0.87927165
130MP0002572_abnormal_emotion/affect_behav0.87925778
131MP0005375_adipose_tissue_phenotype0.87355775
132MP0002932_abnormal_joint_morphology0.86923697
133MP0005670_abnormal_white_adipose0.86808200
134MP0003936_abnormal_reproductive_system0.86308873
135MP0004087_abnormal_muscle_fiber0.85205961
136MP0008995_early_reproductive_senescence0.84602831
137MP0002177_abnormal_outer_ear0.84564825
138MP0005257_abnormal_intraocular_pressure0.84105922
139MP0002086_abnormal_extraembryonic_tissu0.83334575
140MP0001340_abnormal_eyelid_morphology0.82990037
141MP0000013_abnormal_adipose_tissue0.82301388
142MP0002752_abnormal_somatic_nervous0.81906170
143MP0001958_emphysema0.81769293
144MP0001970_abnormal_pain_threshold0.80455856
145MP0010630_abnormal_cardiac_muscle0.79758066
146MP0003303_peritoneal_inflammation0.79752498
147MP0008877_abnormal_DNA_methylation0.79041196
148MP0000759_abnormal_skeletal_muscle0.78667006
149MP0000462_abnormal_digestive_system0.78431775
150MP0002557_abnormal_social/conspecific_i0.78406171
151MP0008770_decreased_survivor_rate0.77963559
152MP0004185_abnormal_adipocyte_glucose0.77640611
153MP0001879_abnormal_lymphatic_vessel0.77381584
154MP0004019_abnormal_vitamin_homeostasis0.76871641
155MP0001944_abnormal_pancreas_morphology0.76656904
156MP0003300_gastrointestinal_ulcer0.76497342
157MP0001188_hyperpigmentation0.76251047
158MP0002114_abnormal_axial_skeleton0.75552776
159MP0003453_abnormal_keratinocyte_physiol0.75533327
160MP0001672_abnormal_embryogenesis/_devel0.75494352
161MP0005380_embryogenesis_phenotype0.75494352
162MP0002111_abnormal_tail_morphology0.73465140

Predicted human phenotypes

RankGene SetZ-score
1Persistence of primary teeth (HP:0006335)4.26128016
2Cerebral aneurysm (HP:0004944)3.85504477
3Abnormality of the proximal phalanges of the hand (HP:0009834)3.74665315
4Osteomalacia (HP:0002749)3.60072870
5Abnormality of the middle phalanges of the toes (HP:0010183)3.56653421
6Shallow orbits (HP:0000586)3.50903939
7Concave nail (HP:0001598)3.47557389
8Oligodontia (HP:0000677)3.46741910
9Short hallux (HP:0010109)3.42401260
10Genetic anticipation (HP:0003743)3.31443622
11Short 4th metacarpal (HP:0010044)3.29196334
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.29196334
13Aplasia involving bones of the upper limbs (HP:0009823)3.20919497
14Aplasia of the phalanges of the hand (HP:0009802)3.20919497
15Aplasia involving bones of the extremities (HP:0009825)3.20919497
16Short femoral neck (HP:0100864)3.18011867
17Aplasia/Hypoplasia of the hallux (HP:0008362)3.12239592
18Abnormality of the nasal septum (HP:0000419)2.95703695
19Clumsiness (HP:0002312)2.92494952
20Abnormality of the frontal sinuses (HP:0002687)2.87842738
21Premature rupture of membranes (HP:0001788)2.86724369
22Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.85758834
23Protrusio acetabuli (HP:0003179)2.81711449
24Chronic hepatic failure (HP:0100626)2.80321193
25Abnormality of the phalanges of the 2nd finger (HP:0009541)2.78586505
26Broad hallux (HP:0010055)2.73148731
27Synostosis of carpal bones (HP:0005048)2.70332742
28Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.60566819
29Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.55358942
30Hyperacusis (HP:0010780)2.55087064
31Abnormality of the 4th metacarpal (HP:0010012)2.54889548
32Conjunctival hamartoma (HP:0100780)2.54887592
33Turricephaly (HP:0000262)2.52102939
34Atrophic scars (HP:0001075)2.51501033
35Symphalangism affecting the phalanges of the hand (HP:0009773)2.50888573
36Periauricular skin pits (HP:0100277)2.49015222
37Preauricular pit (HP:0004467)2.49015222
38Abnormality of the phalanges of the 5th finger (HP:0004213)2.48974389
39Hyperphosphatemia (HP:0002905)2.46607417
40Abnormal number of incisors (HP:0011064)2.46348252
41Abnormality of the 2nd finger (HP:0004100)2.44871970
42Genu recurvatum (HP:0002816)2.44172753
43Septo-optic dysplasia (HP:0100842)2.43967758
44Maternal diabetes (HP:0009800)2.39439250
45Hypoplasia of the ulna (HP:0003022)2.39157708
46Difficulty climbing stairs (HP:0003551)2.37205069
47Progressive cerebellar ataxia (HP:0002073)2.35210132
48Fibular aplasia (HP:0002990)2.35128761
49Bronchomalacia (HP:0002780)2.33440199
50Vascular calcification (HP:0004934)2.28718653
51Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.28258635
52Broad metatarsal (HP:0001783)2.28059472
53Spinal canal stenosis (HP:0003416)2.27945696
54Humeroradial synostosis (HP:0003041)2.27373554
55Synostosis involving the elbow (HP:0003938)2.27373554
56Broad toe (HP:0001837)2.25740568
57Radial bowing (HP:0002986)2.21731315
58Increased connective tissue (HP:0009025)2.21539019
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19079312
60Short 1st metacarpal (HP:0010034)2.19079312
61Abnormality of the lower motor neuron (HP:0002366)2.16143583
62Obstructive sleep apnea (HP:0002870)2.14101976
63Abnormality of the astrocytes (HP:0100707)2.13932167
64Astrocytoma (HP:0009592)2.13932167
65Sleep apnea (HP:0010535)2.11377489
66Fragile skin (HP:0001030)2.10554603
67Mitral valve prolapse (HP:0001634)2.10437026
68Bone cyst (HP:0012062)2.10218248
69Pendular nystagmus (HP:0012043)2.09913091
70Slender long bone (HP:0003100)2.08872595
71Aplasia/hypoplasia of the femur (HP:0005613)2.06810409
72Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.05382539
73Cardiovascular calcification (HP:0011915)2.05269323
74Ankle contracture (HP:0006466)2.05266131
75Wrist flexion contracture (HP:0001239)2.05191138
76Arnold-Chiari malformation (HP:0002308)2.04858400
77Aplasia/Hypoplasia of the patella (HP:0006498)2.03920618
78Adactyly (HP:0009776)2.03728929
79Hypoplasia of dental enamel (HP:0006297)2.01667915
80Bladder diverticulum (HP:0000015)2.01651309
81Renal duplication (HP:0000075)2.01035240
82Skin pits (HP:0100276)2.00450527
83Carpal synostosis (HP:0009702)1.99845491
84Aplasia/Hypoplasia of the fibula (HP:0006492)1.99575452
85Hamartoma of the eye (HP:0010568)1.97526065
86Distal upper limb amyotrophy (HP:0007149)1.97246141
87Upper limb amyotrophy (HP:0009129)1.97246141
88Rib fusion (HP:0000902)1.96207413
89Abnormality of the columella (HP:0009929)1.95504479
90Abnormality of the 1st metacarpal (HP:0010009)1.95497056
91Abnormal number of erythroid precursors (HP:0012131)1.95162077
92Shawl scrotum (HP:0000049)1.95124507
93Ependymoma (HP:0002888)1.94743051
94Dilatation of the ascending aorta (HP:0005111)1.94587395
95Hypoplasia of the uterus (HP:0000013)1.94543996
96Congenital, generalized hypertrichosis (HP:0004540)1.94223579
97Aneurysm (HP:0002617)1.93851262
98Mildly elevated creatine phosphokinase (HP:0008180)1.93751881
99Abnormality of the pulmonary veins (HP:0011718)1.92995104
100Failure to thrive in infancy (HP:0001531)1.92585733
101Ankyloglossia (HP:0010296)1.89757058
102Annular pancreas (HP:0001734)1.88644206
103Mesomelia (HP:0003027)1.88268827
104Nephronophthisis (HP:0000090)1.87956614
105Small hand (HP:0200055)1.86859898
106Decreased circulating renin level (HP:0003351)1.86498422
107Bowel diverticulosis (HP:0005222)1.86133302
108Asplenia (HP:0001746)1.85364180
109Abnormality of the aortic arch (HP:0012303)1.85044322
110Hand muscle atrophy (HP:0009130)1.84831518
1112-3 toe syndactyly (HP:0004691)1.84521463
112Aplasia/Hypoplasia of the ulna (HP:0006495)1.84191730
113Aortic aneurysm (HP:0004942)1.83230445
114Anomalous pulmonary venous return (HP:0010772)1.82264326
115Neoplasm of the heart (HP:0100544)1.80357735
116Milia (HP:0001056)1.79949155
117Subacute progressive viral hepatitis (HP:0006572)1.79412153
118Pointed chin (HP:0000307)1.79346312
119Syncope (HP:0001279)1.79187521
120Hypoplasia of the maxilla (HP:0000327)1.78967832
121Aortic dissection (HP:0002647)1.78642396
122Abnormality of the parietal bone (HP:0002696)1.78275509
123Partial duplication of the phalanx of hand (HP:0009999)1.78217969
124Right ventricular cardiomyopathy (HP:0011663)1.78023340
125Abnormality of oral frenula (HP:0000190)1.78009751
126Hypercortisolism (HP:0001578)1.77914407
127Distal lower limb amyotrophy (HP:0008944)1.77665968
128Abnormality of the incisor (HP:0000676)1.77128171
129Amblyopia (HP:0000646)1.76170205
130Shoulder girdle muscle weakness (HP:0003547)1.76010451
131Lymphangioma (HP:0100764)1.75915049
132Lower limb amyotrophy (HP:0007210)1.75701920
133Missing ribs (HP:0000921)1.75586530
134Short humerus (HP:0005792)1.75327010
135Pelvic girdle muscle weakness (HP:0003749)1.75008105
136Overgrowth (HP:0001548)1.74826132
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.74316862
138Bulbous nose (HP:0000414)1.72481017
139Short phalanx of the thumb (HP:0009660)1.71511815
140Macroorchidism (HP:0000053)1.71252575
141Meningioma (HP:0002858)1.70713063
142Hyperextensible skin (HP:0000974)1.70143692
143Congenital glaucoma (HP:0001087)1.69735893
144Hyperthyroidism (HP:0000836)1.69266554
145Exotropia (HP:0000577)1.68484791
146Fused cervical vertebrae (HP:0002949)1.68198512
147Patellar aplasia (HP:0006443)1.67121156
148Keratoconus (HP:0000563)1.66551410
149Increased corneal curvature (HP:0100692)1.66551410
150Urethral obstruction (HP:0000796)1.66545132
151Aplasia/hypoplasia of the uterus (HP:0008684)1.65080328
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65004061
153Visual hallucinations (HP:0002367)1.64773115
154Arterial tortuosity (HP:0005116)1.63887623
155Abnormality of the labia minora (HP:0012880)1.62250467
156Coronal craniosynostosis (HP:0004440)1.61525825
157Sudden death (HP:0001699)1.61481528
158Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60915158
159Vertebral hypoplasia (HP:0008417)1.60915158
160Vascular tortuosity (HP:0004948)1.60109727
161Selective tooth agenesis (HP:0001592)1.59993411
162Aplasia/hypoplasia of the humerus (HP:0006507)1.59881053
163Vertebral fusion (HP:0002948)1.58375696
164Striae distensae (HP:0001065)1.56933678
165Hypoventilation (HP:0002791)1.55837170
166Ulnar bowing (HP:0003031)1.55557026
167Rapidly progressive (HP:0003678)1.55418337
168Elfin facies (HP:0004428)1.55396829
169Insomnia (HP:0100785)1.54645976
170Megalencephaly (HP:0001355)1.54471837
171Achilles tendon contracture (HP:0001771)1.53917440
172Alopecia of scalp (HP:0002293)1.53367658
173Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.53282900
174Deviation of the hallux (HP:0010051)1.52935132
175Round ear (HP:0100830)1.52601025
176Abnormality of the hip-girdle musculature (HP:0001445)1.51908681
177Abnormality of the musculature of the pelvis (HP:0001469)1.51908681
178Long toe (HP:0010511)1.51422916
179Thin ribs (HP:0000883)1.51217443
180Abnormality of the distal phalanges of the toes (HP:0010182)1.50859625
181Spinal rigidity (HP:0003306)1.50633151
182Abnormality of the radial head (HP:0003995)1.50130356
183Congenital hip dislocation (HP:0001374)1.49780186
184Malignant gastrointestinal tract tumors (HP:0006749)1.49045099
185Gastrointestinal carcinoma (HP:0002672)1.49045099
186Morphological abnormality of the middle ear (HP:0008609)1.47609810
187Enlarged penis (HP:0000040)1.46818966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.95600956
2TRIB32.96888766
3RIPK12.84381782
4EPHA22.66600107
5TYRO32.61447348
6MAP3K92.59029755
7ICK2.50459434
8PDGFRA2.43386528
9LATS22.39821602
10GRK12.36494469
11DDR22.30223801
12MARK12.23557322
13MAPK152.07488295
14SGK21.99189440
15EEF2K1.94569321
16SGK2231.91222466
17SGK4941.91222466
18EPHB21.85738652
19PKN21.78634161
20FER1.72543598
21TTN1.67587042
22MAP3K101.67030231
23RPS6KA61.63039018
24DMPK1.56277912
25CDK121.51413997
26PTK61.49384428
27PAK61.48439765
28ALK1.47240665
29SGK31.47153572
30FRK1.47129855
31PTK21.46476492
32DYRK1B1.40241596
33PAK31.36586339
34NTRK11.33461713
35SIK11.33111441
36TAF11.33024239
37NTRK21.30755845
38PHKG21.30407812
39PHKG11.30407812
40CASK1.28942300
41BMX1.27841662
42ADRBK21.26987786
43PAK41.26202979
44KSR11.24838478
45CAMK1G1.19714426
46SMG11.18153076
47CHUK1.12321350
48MAPK131.10435943
49UHMK11.09556204
50MTOR1.08926177
51PINK11.08689588
52MARK21.07834486
53PRKD21.07691051
54CAMK1D1.06680475
55STK381.06335961
56SIK21.06178465
57DAPK21.03448944
58FGFR40.98697745
59TAOK10.96280433
60HIPK20.91554906
61MINK10.91312801
62PDGFRB0.84679364
63PRKD30.83376865
64PAK20.82792176
65PRKCZ0.80701080
66EPHA30.79873602
67STK110.79583679
68CDC42BPA0.79326491
69PRKCG0.78858827
70TGFBR20.78656196
71MAP2K70.78392197
72TNIK0.76868588
73FGFR10.75783054
74MUSK0.75527039
75AKT30.74319528
76EPHB10.74000449
77PNCK0.73415292
78CAMK10.70994816
79KSR20.70989269
80CAMK40.70521453
81DYRK20.70475934
82PRKCH0.70387672
83ERN10.69736747
84CAMKK10.69227797
85RPS6KA20.68662945
86RET0.68632979
87MAP3K70.68577224
88CDK60.67500193
89MAPK70.67329636
90LATS10.65824891
91MATK0.65811844
92FGR0.65319460
93MAP2K20.65224471
94CAMK2B0.64755083
95MAPK120.63366704
96ERBB20.63183692
97NTRK30.62298385
98ERBB30.61801757
99ADRBK10.61563646
100FGFR20.61456126
101PIK3CA0.60716593
102GSK3A0.60268618
103AURKA0.59676974
104LMTK20.58332560
105MAP3K20.58275642
106CDK50.58144211
107RPS6KC10.57875392
108RPS6KL10.57875392
109NEK10.57711583
110FGFR30.57613154
111TNK20.57430455
112GRK60.56287852
113CSK0.55697565
114GRK70.54705725
115CDK140.53998438
116PRKAA10.53429783
117STK100.53302322
118GRK50.52766773
119SGK10.52619744
120CDK150.51822811
121MAP2K40.51770081
122MAPKAPK30.51295375
123CDK180.51077884
124MAP3K40.49621661
125IKBKB0.49526154
126LIMK10.49316232
127MAPK80.49152564
128PRKCI0.48722367
129PRKD10.48057626
130INSR0.47364576
131RPS6KA10.47155796
132ROCK10.46367125
133CDK11A0.46102378
134NEK90.45605722
135PRPF4B0.45351837
136MAPK90.45285690
137DYRK30.45028962
138PRKACA0.44312368
139MAP2K10.43957168
140MYLK0.41465074
141WNK40.41209407
142CSNK1A10.38280187
143MAPK40.35322135
144STK160.35155206
145AKT10.34839318

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.15792142
2Hippo signaling pathway_Homo sapiens_hsa043901.90599712
3Adherens junction_Homo sapiens_hsa045201.75461173
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70060421
5Endometrial cancer_Homo sapiens_hsa052131.66710481
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65330542
7Axon guidance_Homo sapiens_hsa043601.60217882
8Notch signaling pathway_Homo sapiens_hsa043301.60016437
9Colorectal cancer_Homo sapiens_hsa052101.59808703
10Basal cell carcinoma_Homo sapiens_hsa052171.59426041
11mTOR signaling pathway_Homo sapiens_hsa041501.57099331
12Focal adhesion_Homo sapiens_hsa045101.56963864
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54749399
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48106792
15Sulfur relay system_Homo sapiens_hsa041221.48089018
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47359027
17Renal cell carcinoma_Homo sapiens_hsa052111.44545135
18Olfactory transduction_Homo sapiens_hsa047401.44052755
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42703078
20Dilated cardiomyopathy_Homo sapiens_hsa054141.41075704
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40010691
22Chronic myeloid leukemia_Homo sapiens_hsa052201.39724923
23Estrogen signaling pathway_Homo sapiens_hsa049151.39568598
24Hedgehog signaling pathway_Homo sapiens_hsa043401.38457999
25Gap junction_Homo sapiens_hsa045401.36628603
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36041216
27Glioma_Homo sapiens_hsa052141.35682984
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35244080
29Tight junction_Homo sapiens_hsa045301.32772483
30Proteoglycans in cancer_Homo sapiens_hsa052051.31560107
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31118771
32Phototransduction_Homo sapiens_hsa047441.30375205
33Wnt signaling pathway_Homo sapiens_hsa043101.29630786
34ECM-receptor interaction_Homo sapiens_hsa045121.28493345
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28398491
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28158473
37Bladder cancer_Homo sapiens_hsa052191.26788558
38Vitamin digestion and absorption_Homo sapiens_hsa049771.26542673
39Cardiac muscle contraction_Homo sapiens_hsa042601.25767175
40VEGF signaling pathway_Homo sapiens_hsa043701.24710721
41ErbB signaling pathway_Homo sapiens_hsa040121.24233684
42Melanogenesis_Homo sapiens_hsa049161.21707999
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20718906
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20089081
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19152029
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19016887
47Dorso-ventral axis formation_Homo sapiens_hsa043201.18813033
48MicroRNAs in cancer_Homo sapiens_hsa052061.17414665
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.17020459
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16504224
51Long-term potentiation_Homo sapiens_hsa047201.16387943
52GnRH signaling pathway_Homo sapiens_hsa049121.16241836
53Oxytocin signaling pathway_Homo sapiens_hsa049211.13945506
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13706275
55Synaptic vesicle cycle_Homo sapiens_hsa047211.11649812
56Rap1 signaling pathway_Homo sapiens_hsa040151.11394274
57Insulin secretion_Homo sapiens_hsa049111.11153175
58Dopaminergic synapse_Homo sapiens_hsa047281.10882033
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06284659
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.06265886
61TGF-beta signaling pathway_Homo sapiens_hsa043501.05120592
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04918755
63Serotonergic synapse_Homo sapiens_hsa047261.01839297
64Gastric acid secretion_Homo sapiens_hsa049711.01661888
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.01183063
66Choline metabolism in cancer_Homo sapiens_hsa052311.00133763
67Insulin signaling pathway_Homo sapiens_hsa049100.99912200
68Amphetamine addiction_Homo sapiens_hsa050310.99527034
69Amoebiasis_Homo sapiens_hsa051460.99500710
70Circadian entrainment_Homo sapiens_hsa047130.99166224
71Cholinergic synapse_Homo sapiens_hsa047250.98704781
72Salivary secretion_Homo sapiens_hsa049700.98378621
73Ovarian steroidogenesis_Homo sapiens_hsa049130.95376190
74Prolactin signaling pathway_Homo sapiens_hsa049170.95056049
75Cocaine addiction_Homo sapiens_hsa050300.93818579
76Small cell lung cancer_Homo sapiens_hsa052220.92593211
77Viral myocarditis_Homo sapiens_hsa054160.92517060
78Acute myeloid leukemia_Homo sapiens_hsa052210.92131520
79Type II diabetes mellitus_Homo sapiens_hsa049300.91569152
80Prion diseases_Homo sapiens_hsa050200.90593270
81MAPK signaling pathway_Homo sapiens_hsa040100.90286647
82Pancreatic cancer_Homo sapiens_hsa052120.90101371
83GABAergic synapse_Homo sapiens_hsa047270.89594562
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88965385
85Non-small cell lung cancer_Homo sapiens_hsa052230.88669133
86Pathways in cancer_Homo sapiens_hsa052000.87249182
87Prostate cancer_Homo sapiens_hsa052150.87237742
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.86249687
89Alcoholism_Homo sapiens_hsa050340.84484040
90Renin secretion_Homo sapiens_hsa049240.84270962
91Nicotine addiction_Homo sapiens_hsa050330.82182113
92Calcium signaling pathway_Homo sapiens_hsa040200.80627191
93Long-term depression_Homo sapiens_hsa047300.80014046
94Melanoma_Homo sapiens_hsa052180.79469730
95AMPK signaling pathway_Homo sapiens_hsa041520.79285818
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78929450
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77876588
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76474979
99Ras signaling pathway_Homo sapiens_hsa040140.75420386
100Glutamatergic synapse_Homo sapiens_hsa047240.74939720
101Thyroid cancer_Homo sapiens_hsa052160.74612131
102Endocytosis_Homo sapiens_hsa041440.74259294
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.74168118
104cAMP signaling pathway_Homo sapiens_hsa040240.73678574
105Sulfur metabolism_Homo sapiens_hsa009200.73482259
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72905626
107FoxO signaling pathway_Homo sapiens_hsa040680.72070891
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71828175
109Ribosome_Homo sapiens_hsa030100.71391508
110Taste transduction_Homo sapiens_hsa047420.70415730
111Insulin resistance_Homo sapiens_hsa049310.70017236
112Morphine addiction_Homo sapiens_hsa050320.69072782
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67013975
114Glucagon signaling pathway_Homo sapiens_hsa049220.66973548
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66882944
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66468242
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65395164
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65389369
119HTLV-I infection_Homo sapiens_hsa051660.64702625
120Systemic lupus erythematosus_Homo sapiens_hsa053220.62561917
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.62072319
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60365441
123Selenocompound metabolism_Homo sapiens_hsa004500.52043979
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51186466
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50946768

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »