IRF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.37004462
2* keratinocyte proliferation (GO:0043616)6.43167107
3cell-substrate junction assembly (GO:0007044)5.76095633
4regulation of keratinocyte proliferation (GO:0010837)5.46667994
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.44894294
6intermediate filament organization (GO:0045109)5.41206885
7establishment of skin barrier (GO:0061436)5.28823495
8regulation of water loss via skin (GO:0033561)5.28728197
9hemidesmosome assembly (GO:0031581)5.23122093
10keratinocyte development (GO:0003334)5.10856292
11epidermis development (GO:0008544)5.04270080
12surfactant homeostasis (GO:0043129)4.84249083
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81102197
14L-phenylalanine catabolic process (GO:0006559)4.81102197
15intestinal cholesterol absorption (GO:0030299)4.71180253
16gap junction assembly (GO:0016264)4.63532605
17establishment of tissue polarity (GO:0007164)4.61330251
18establishment of planar polarity (GO:0001736)4.61330251
19L-phenylalanine metabolic process (GO:0006558)4.59483245
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59483245
21positive regulation of epidermal cell differentiation (GO:0045606)4.40006139
22polarized epithelial cell differentiation (GO:0030859)4.29093536
23chemical homeostasis within a tissue (GO:0048875)4.27296012
24sulfur amino acid catabolic process (GO:0000098)4.21706057
25epithelial cell differentiation involved in prostate gland development (GO:0060742)4.16346169
26positive regulation of epidermis development (GO:0045684)4.14606624
27aromatic amino acid family catabolic process (GO:0009074)4.05740807
28ventricular cardiac muscle cell action potential (GO:0086005)4.00392660
29intestinal absorption (GO:0050892)3.98186939
30regulation of cholesterol homeostasis (GO:2000188)3.97273991
31regulation of hair follicle development (GO:0051797)3.93099078
32multicellular organismal water homeostasis (GO:0050891)3.92995844
33ectoderm development (GO:0007398)3.91000686
34cysteine metabolic process (GO:0006534)3.90536304
35interferon-gamma secretion (GO:0072643)3.88811302
36regulation of keratinocyte differentiation (GO:0045616)3.84833809
37phospholipid efflux (GO:0033700)3.76389193
38peptide cross-linking (GO:0018149)3.72194290
39regulation of transforming growth factor beta2 production (GO:0032909)3.71989982
40keratinization (GO:0031424)3.67105397
41hypotonic response (GO:0006971)3.66803394
42hormone catabolic process (GO:0042447)3.62463937
43indole-containing compound catabolic process (GO:0042436)3.58144926
44indolalkylamine catabolic process (GO:0046218)3.58144926
45tryptophan catabolic process (GO:0006569)3.58144926
46water homeostasis (GO:0030104)3.55782785
47amino-acid betaine metabolic process (GO:0006577)3.54381930
48high-density lipoprotein particle remodeling (GO:0034375)3.53874063
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.53749966
50regulation of phospholipase A2 activity (GO:0032429)3.50356362
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48744907
52tryptophan metabolic process (GO:0006568)3.47989257
53regulation of bile acid biosynthetic process (GO:0070857)3.46889597
54positive regulation of keratinocyte differentiation (GO:0045618)3.46115656
55lateral sprouting from an epithelium (GO:0060601)3.45553310
56regulation of epidermis development (GO:0045682)3.44629623
57diterpenoid biosynthetic process (GO:0016102)3.44605614
58skin morphogenesis (GO:0043589)3.44501187
59bile acid biosynthetic process (GO:0006699)3.44155605
60urea metabolic process (GO:0019627)3.43448846
61urea cycle (GO:0000050)3.43448846
62kynurenine metabolic process (GO:0070189)3.40507086
63epithelial cell-cell adhesion (GO:0090136)3.37973975
64regulation of transforming growth factor beta1 production (GO:0032908)3.35399701
65glyoxylate metabolic process (GO:0046487)3.34799233
66drug transmembrane transport (GO:0006855)3.34265571
67negative regulation of lipase activity (GO:0060192)3.33729221
68bile acid and bile salt transport (GO:0015721)3.32930698
69regulation of triglyceride catabolic process (GO:0010896)3.32329551
70homocysteine metabolic process (GO:0050667)3.31316918
71intermediate filament cytoskeleton organization (GO:0045104)3.30792973
72transcytosis (GO:0045056)3.29530306
73regulation of hair cycle (GO:0042634)3.29522347
74cellular glucuronidation (GO:0052695)3.29401698
75cell adhesion mediated by integrin (GO:0033627)3.29261679
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.26736480
77COPII vesicle coating (GO:0048208)3.26290649
78* keratinocyte differentiation (GO:0030216)3.26271784
79primary alcohol catabolic process (GO:0034310)3.24574526
80linoleic acid metabolic process (GO:0043651)3.22063216
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21361765
82regulation of heart rate by cardiac conduction (GO:0086091)3.21191772
83negative regulation of epidermis development (GO:0045683)3.19624533
84protein carboxylation (GO:0018214)3.17356606
85peptidyl-glutamic acid carboxylation (GO:0017187)3.17356606
86xenobiotic catabolic process (GO:0042178)3.17270023
87intermediate filament-based process (GO:0045103)3.16279580
88reverse cholesterol transport (GO:0043691)3.15008099
89ethanol metabolic process (GO:0006067)3.14779093
90glucuronate metabolic process (GO:0019585)3.14720994
91uronic acid metabolic process (GO:0006063)3.14720994
92bile acid metabolic process (GO:0008206)3.13928041
93regulation of cardioblast differentiation (GO:0051890)3.11072625
94acylglycerol homeostasis (GO:0055090)3.10216690
95triglyceride homeostasis (GO:0070328)3.10216690
96cellular modified amino acid catabolic process (GO:0042219)3.09666146
97sphingoid metabolic process (GO:0046519)3.09518227
98intestinal epithelial cell development (GO:0060576)3.09162983
99positive regulation of hair cycle (GO:0042635)3.08958044
100positive regulation of hair follicle development (GO:0051798)3.08958044
101regulation of cholesterol esterification (GO:0010872)3.08534542
102nitrogen cycle metabolic process (GO:0071941)3.07273918
103cell junction assembly (GO:0034329)3.05033058
104negative regulation of cholesterol transport (GO:0032375)3.02961248
105negative regulation of sterol transport (GO:0032372)3.02961248
106lysine metabolic process (GO:0006553)3.02010357
107lysine catabolic process (GO:0006554)3.02010357
108drug catabolic process (GO:0042737)3.00761024
109regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.99126675
110regulation of protein activation cascade (GO:2000257)2.99017834
111serine family amino acid catabolic process (GO:0009071)2.97762001
112regulation of epidermal cell differentiation (GO:0045604)2.96812973
113cell communication involved in cardiac conduction (GO:0086065)2.96415811
114response to nitrosative stress (GO:0051409)2.95678566
115alpha-linolenic acid metabolic process (GO:0036109)2.94954891
116cell junction organization (GO:0034330)2.94293378
117complement activation, alternative pathway (GO:0006957)2.93214656
118aromatic amino acid family metabolic process (GO:0009072)2.93084955
119atrioventricular valve morphogenesis (GO:0003181)2.91175324
120fibrinolysis (GO:0042730)2.90580550
121COPI coating of Golgi vesicle (GO:0048205)2.90162658
122Golgi transport vesicle coating (GO:0048200)2.90162658
123tight junction assembly (GO:0070830)2.89757045
124apical protein localization (GO:0045176)2.88888481
125benzene-containing compound metabolic process (GO:0042537)2.88661165
126regulation of transforming growth factor beta production (GO:0071634)2.87971264
127carnitine metabolic process (GO:0009437)2.86964668
128protein localization to endosome (GO:0036010)2.86939623
129sphingosine metabolic process (GO:0006670)2.85768875
130imidazole-containing compound metabolic process (GO:0052803)2.85544929
131mesodermal cell differentiation (GO:0048333)2.85493742
132cell-cell junction assembly (GO:0007043)2.84149843
133regulation of complement activation (GO:0030449)2.81677973
134plasma lipoprotein particle remodeling (GO:0034369)2.81584297
135protein-lipid complex remodeling (GO:0034368)2.81584297
136macromolecular complex remodeling (GO:0034367)2.81584297
137lipoprotein metabolic process (GO:0042157)2.81301340
138regulation of fibrinolysis (GO:0051917)2.80668526
139endosome organization (GO:0007032)2.79777067
140tyrosine metabolic process (GO:0006570)2.78489106
1414-hydroxyproline metabolic process (GO:0019471)2.78125008
142morphogenesis of embryonic epithelium (GO:0016331)2.77061045
143flavonoid metabolic process (GO:0009812)2.76388888
144negative regulation of keratinocyte proliferation (GO:0010839)2.75756999
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75561657
146* epidermal cell differentiation (GO:0009913)2.73926524
147peptide catabolic process (GO:0043171)2.72944604
148glutathione derivative metabolic process (GO:1901685)2.72457730
149glutathione derivative biosynthetic process (GO:1901687)2.72457730
150molting cycle (GO:0042303)2.72344690
151hair cycle (GO:0042633)2.72344690
152negative regulation of fibrinolysis (GO:0051918)2.69995573
153retinal metabolic process (GO:0042574)2.69602913
154cholesterol homeostasis (GO:0042632)2.69564853
155negative regulation of chondrocyte differentiation (GO:0032331)2.68785215
1563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.68765088
157axonemal dynein complex assembly (GO:0070286)2.68590540
158regulation of endothelial cell chemotaxis (GO:2001026)2.67604730
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64496251
160branching involved in mammary gland duct morphogenesis (GO:0060444)2.61126521
161L-serine transport (GO:0015825)2.58708918
162regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57596684
163epithelium development (GO:0060429)2.57260791
164renal filtration (GO:0097205)2.56076158
165cardiac conduction (GO:0061337)2.55540699
166calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.54704415
167regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.52429175
168asymmetric protein localization (GO:0008105)2.50921395
169establishment of apical/basal cell polarity (GO:0035089)2.49053439
170oocyte development (GO:0048599)2.47832287
171skin development (GO:0043588)2.46968710
172terpenoid biosynthetic process (GO:0016114)2.43193430
173iron ion import (GO:0097286)2.43045590
174endodermal cell differentiation (GO:0035987)2.41792360
175negative regulation of cell fate specification (GO:0009996)2.41299969
176filopodium assembly (GO:0046847)2.40407612
177columnar/cuboidal epithelial cell development (GO:0002066)2.38189225
178pyrimidine-containing compound transmembrane transport (GO:0072531)2.38140441
179cardiac right ventricle morphogenesis (GO:0003215)2.37686873
180regulation of protein localization to cell surface (GO:2000008)2.36449345
181genitalia morphogenesis (GO:0035112)2.35802063
182retinol metabolic process (GO:0042572)2.34417779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.92553933
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.53639076
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.45564118
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.10586679
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.63245002
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.39101356
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.94158608
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.59141491
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43937963
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42375340
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30773072
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.30682313
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.25472107
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12146850
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.10609168
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.10438851
17GATA4_25053715_ChIP-Seq_YYC3_Human2.06509381
18TP63_17297297_ChIP-ChIP_HaCaT_Human10.9682742
19P63_26484246_Chip-Seq_KERATINOCYTES_Human1.95551419
20GATA1_22025678_ChIP-Seq_K562_Human1.94640019
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.92936705
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.92341121
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91874327
24ZNF263_19887448_ChIP-Seq_K562_Human1.91772832
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.89164804
26* SOX2_20726797_ChIP-Seq_SW620_Human1.86409949
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72141785
28GATA6_25053715_ChIP-Seq_YYC3_Human1.63809004
29* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55332196
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55332196
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54464450
32* CLOCK_20551151_ChIP-Seq_293T_Human1.48628074
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48572821
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41135275
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.34972380
36GATA3_24758297_ChIP-Seq_MCF-7_Human1.34052596
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33196763
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31744732
39* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31370400
40* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30124563
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29261720
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.27545282
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27100733
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.26295278
45AR_21909140_ChIP-Seq_LNCAP_Human1.25087762
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21187377
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19830373
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19718953
49* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18744429
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.17215160
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15681365
52* TP63_23658742_ChIP-Seq_EP156T_Human1.15000561
53* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11242362
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10410118
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.09635410
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09019064
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08653321
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99793457
59AHR_22903824_ChIP-Seq_MCF-7_Human0.98201558
60ATF3_27146783_Chip-Seq_COLON_Human0.96861045
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96260697
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94966988
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94344951
64KLF5_25053715_ChIP-Seq_YYC3_Human0.94208292
65FOXA1_25552417_ChIP-Seq_VCAP_Human0.92629752
66CJUN_26792858_Chip-Seq_BT549_Human0.92453199
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92382973
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91761117
69SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90754543
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90521780
71FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88534283
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86693502
73HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85477096
74EGR1_19032775_ChIP-ChIP_M12_Human0.84040846
75* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83906822
76CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83675751
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83355945
78* TP63_22573176_ChIP-Seq_HFKS_Human0.83052029
79GATA2_21666600_ChIP-Seq_HMVEC_Human0.82606888
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81837961
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81525372
82* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80739351
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.80692345
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79921184
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.79816865
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78755572
87EP300_21415370_ChIP-Seq_HL-1_Mouse0.76942522
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73963161
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73378797
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73378797
91BCAT_22108803_ChIP-Seq_LS180_Human0.72471347
92CEBPB_22108803_ChIP-Seq_LS180_Human0.72435775
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71962832
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71828100
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.71818802
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71558479
97RXR_22108803_ChIP-Seq_LS180_Human0.70720296
98CREB1_26743006_Chip-Seq_LNCaP_Human0.67208823
99TP53_16413492_ChIP-PET_HCT116_Human0.67120692
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.66867136
101LXR_22292898_ChIP-Seq_THP-1_Human0.65636766
102ELF5_23300383_ChIP-Seq_T47D_Human0.65304191
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.65249198
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.65047999
105CDX2_22108803_ChIP-Seq_LS180_Human0.65020201
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64757470
107TP53_18474530_ChIP-ChIP_U2OS_Human0.64510279
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64333504
109UBF1/2_26484160_Chip-Seq_HMECs_Human0.64006411
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63526439
111SMC4_20622854_ChIP-Seq_HELA_Human0.61977828
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61497687
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61112702
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60948824
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60660889
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.60158559
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.60158559
118CHD1_26751641_Chip-Seq_LNCaP_Human0.60017409
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.58418204
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.58375868
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57254428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.88500481
2MP0002796_impaired_skin_barrier4.55198292
3MP0005360_urolithiasis4.18546400
4MP0002139_abnormal_hepatobiliary_system4.14736868
5MP0005085_abnormal_gallbladder_physiolo3.97723764
6MP0005365_abnormal_bile_salt3.84935457
7MP0002254_reproductive_system_inflammat3.34380936
8MP0001666_abnormal_nutrient_absorption2.97621060
9MP0008875_abnormal_xenobiotic_pharmacok2.96433766
10MP0005409_darkened_coat_color2.76643547
11MP0005501_abnormal_skin_physiology2.69358480
12MP0010678_abnormal_skin_adnexa2.55954285
13MP0000383_abnormal_hair_follicle2.48289868
14MP0009379_abnormal_foot_pigmentation2.43700630
15MP0004264_abnormal_extraembryonic_tissu2.42912540
16MP0000579_abnormal_nail_morphology2.42878372
17MP0003252_abnormal_bile_duct2.41392614
18MP0005275_abnormal_skin_tensile2.27215481
19* MP0002098_abnormal_vibrissa_morphology2.23612538
20* MP0001216_abnormal_epidermal_layer2.15372228
21MP0004019_abnormal_vitamin_homeostasis2.14620696
22MP0004381_abnormal_hair_follicle2.08181154
23MP0009780_abnormal_chondrocyte_physiolo2.08176841
24MP0005083_abnormal_biliary_tract2.07159332
25* MP0002060_abnormal_skin_morphology2.05355988
26MP0003195_calcinosis1.96378351
27* MP0003453_abnormal_keratinocyte_physiol1.92769020
28MP0010329_abnormal_lipoprotein_level1.86921541
29MP0002009_preneoplasia1.75427093
30MP0003705_abnormal_hypodermis_morpholog1.73925245
31MP0004272_abnormal_basement_membrane1.61551956
32MP0004947_skin_inflammation1.58374211
33* MP0010771_integument_phenotype1.57981050
34* MP0000377_abnormal_hair_follicle1.57493704
35MP0000427_abnormal_hair_cycle1.56606290
36MP0003806_abnormal_nucleotide_metabolis1.54790066
37MP0000647_abnormal_sebaceous_gland1.52082456
38MP0009840_abnormal_foam_cell1.47692206
39MP0003300_gastrointestinal_ulcer1.41948239
40MP0003191_abnormal_cellular_cholesterol1.41786690
41MP0000537_abnormal_urethra_morphology1.40564687
42MP0000678_abnormal_parathyroid_gland1.39832405
43MP0001346_abnormal_lacrimal_gland1.39229792
44MP0005220_abnormal_exocrine_pancreas1.33401637
45MP0002138_abnormal_hepatobiliary_system1.31893536
46* MP0000467_abnormal_esophagus_morphology1.31359648
47MP0003566_abnormal_cell_adhesion1.29642286
48MP0009643_abnormal_urine_homeostasis1.27576626
49MP0005332_abnormal_amino_acid1.27002111
50MP0002877_abnormal_melanocyte_morpholog1.23541418
51MP0005451_abnormal_body_composition1.20659813
52MP0009053_abnormal_anal_canal1.20062787
53MP0003315_abnormal_perineum_morphology1.17415532
54MP0003868_abnormal_feces_composition1.17212688
55MP0002118_abnormal_lipid_homeostasis1.15534901
56MP0010352_gastrointestinal_tract_polyps1.13495450
57MP0004043_abnormal_pH_regulation1.11409041
58MP0000609_abnormal_liver_physiology1.11349664
59MP0001191_abnormal_skin_condition1.11132679
60MP0002234_abnormal_pharynx_morphology1.08272789
61MP0000613_abnormal_salivary_gland1.03818239
62* MP0000762_abnormal_tongue_morphology1.03182408
63* MP0009931_abnormal_skin_appearance1.02747858
64MP0000538_abnormal_urinary_bladder1.02656326
65MP0001765_abnormal_ion_homeostasis0.99700461
66MP0000367_abnormal_coat/_hair0.98763494
67MP0001849_ear_inflammation0.97156391
68MP0008004_abnormal_stomach_pH0.94812854
69MP0005636_abnormal_mineral_homeostasis0.94467956
70MP0002876_abnormal_thyroid_physiology0.90969746
71MP0002166_altered_tumor_susceptibility0.88498656
72MP0008789_abnormal_olfactory_epithelium0.87716297
73MP0003045_fibrosis0.86306992
74MP0004782_abnormal_surfactant_physiolog0.85950550
75MP0000462_abnormal_digestive_system0.84149738
76* MP0003941_abnormal_skin_development0.83505163
77MP0001756_abnormal_urination0.82361233
78MP0001851_eye_inflammation0.82265213
79MP0004185_abnormal_adipocyte_glucose0.81831761
80MP0009384_cardiac_valve_regurgitation0.80914708
81MP0005319_abnormal_enzyme/_coenzyme0.80876724
82MP0001944_abnormal_pancreas_morphology0.80862611
83MP0005248_abnormal_Harderian_gland0.80376677
84MP0003950_abnormal_plasma_membrane0.79908883
85MP0005408_hypopigmentation0.76691619
86MP0005647_abnormal_sex_gland0.76674651
87MP0003183_abnormal_peptide_metabolism0.71642830
88MP0005257_abnormal_intraocular_pressure0.71149198
89MP0001243_abnormal_dermal_layer0.70898039
90MP0005084_abnormal_gallbladder_morpholo0.70889530
91MP0005023_abnormal_wound_healing0.70657651
92MP0002693_abnormal_pancreas_physiology0.70118135
93MP0004885_abnormal_endolymph0.68333359
94MP0008260_abnormal_autophagy0.65039180
95MP0001881_abnormal_mammary_gland0.64915059
96MP0000627_abnormal_mammary_gland0.64406086
97MP0000858_altered_metastatic_potential0.64238667
98MP0010155_abnormal_intestine_physiology0.64232173
99MP0002282_abnormal_trachea_morphology0.64146750
100MP0002896_abnormal_bone_mineralization0.63310509
101MP0003638_abnormal_response/metabolism_0.62106598
102MP0002136_abnormal_kidney_physiology0.61124106
103MP0002277_abnormal_respiratory_mucosa0.61057030
104MP0002006_tumorigenesis0.60847532
105MP0000003_abnormal_adipose_tissue0.59844307
106MP0010368_abnormal_lymphatic_system0.59375545
107MP0009765_abnormal_xenobiotic_induced0.59334103
108MP0000470_abnormal_stomach_morphology0.59131409
109MP0005499_abnormal_olfactory_system0.58534411
110MP0005394_taste/olfaction_phenotype0.58534411
111MP0001873_stomach_inflammation0.58472517
112MP0005395_other_phenotype0.58160212
113MP0005367_renal/urinary_system_phenotyp0.58084531
114MP0000516_abnormal_urinary_system0.58084531
115* MP0003755_abnormal_palate_morphology0.57633130
116MP0002168_other_aberrant_phenotype0.56280983
117MP0001764_abnormal_homeostasis0.56179505
118MP0003011_delayed_dark_adaptation0.55722055
119MP0001340_abnormal_eyelid_morphology0.54879050
120MP0006054_spinal_hemorrhage0.54293016
121MP0003091_abnormal_cell_migration0.53289208
122MP0005076_abnormal_cell_differentiation0.52679292
123MP0002249_abnormal_larynx_morphology0.51397077
124MP0003718_maternal_effect0.51389227
125MP0000477_abnormal_intestine_morphology0.46724573
126MP0005375_adipose_tissue_phenotype0.46610924
127MP0002089_abnormal_postnatal_growth/wei0.45428827
128MP0006138_congestive_heart_failure0.44191884
129MP0010030_abnormal_orbit_morphology0.43132459
130MP0000013_abnormal_adipose_tissue0.40883434
131MP0000465_gastrointestinal_hemorrhage0.38113668
132MP0002233_abnormal_nose_morphology0.38084560

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.64980263
2Intrahepatic cholestasis (HP:0001406)5.47466222
3Plantar hyperkeratosis (HP:0007556)4.52218109
4Onycholysis (HP:0001806)4.51989912
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.49567609
6Woolly hair (HP:0002224)4.45314396
7Ridged nail (HP:0001807)4.37276872
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.31692850
9Hypobetalipoproteinemia (HP:0003563)4.26287640
10Hypotrichosis (HP:0001006)4.25267310
11Xanthomatosis (HP:0000991)4.05539302
12Fragile nails (HP:0001808)4.03637656
13Pili torti (HP:0003777)3.99532423
14Milia (HP:0001056)3.95451905
15Fat malabsorption (HP:0002630)3.85452077
16Palmoplantar hyperkeratosis (HP:0000972)3.71416910
17Sparse scalp hair (HP:0002209)3.49806826
18Palmar hyperkeratosis (HP:0010765)3.49239589
19Conjugated hyperbilirubinemia (HP:0002908)3.46686242
20Hypoglycemic coma (HP:0001325)3.44958486
21Deep venous thrombosis (HP:0002625)3.42367697
22Epidermoid cyst (HP:0200040)3.29068707
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24876358
24Prolonged partial thromboplastin time (HP:0003645)3.23792665
25Malnutrition (HP:0004395)3.15118624
26Congenital ichthyosiform erythroderma (HP:0007431)3.11015798
27Oral leukoplakia (HP:0002745)3.02446023
28Selective tooth agenesis (HP:0001592)3.01507165
29Hyperglycinuria (HP:0003108)2.98954284
30Hypolipoproteinemia (HP:0010981)2.98442735
31Abnormal hair laboratory examination (HP:0003328)2.97839418
32Steatorrhea (HP:0002570)2.92019016
33Absent eyelashes (HP:0000561)2.90099828
34Parakeratosis (HP:0001036)2.88397681
35Dry hair (HP:0011359)2.82426275
36Fragile skin (HP:0001030)2.82160621
37Ankyloglossia (HP:0010296)2.81591706
38* Lip pit (HP:0100267)2.77317848
39Palmoplantar keratoderma (HP:0000982)2.72595793
40Ketosis (HP:0001946)2.72400368
41Abnormality of the common coagulation pathway (HP:0010990)2.72158781
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71688667
43Abnormal blistering of the skin (HP:0008066)2.68265660
44Abnormality of nail color (HP:0100643)2.67714160
45Abnormality of the intrinsic pathway (HP:0010989)2.67121811
46Ketoacidosis (HP:0001993)2.63754913
47Hyperlipoproteinemia (HP:0010980)2.62911779
48Complement deficiency (HP:0004431)2.61403726
49Hyperglycinemia (HP:0002154)2.60050690
50Atrophic scars (HP:0001075)2.59121350
51Increased IgE level (HP:0003212)2.58729349
52Oligodontia (HP:0000677)2.57731108
53Abnormality of permanent molar morphology (HP:0011071)2.57590175
54Abnormality of the dental root (HP:0006486)2.57590175
55Taurodontia (HP:0000679)2.57590175
56Abnormal hemoglobin (HP:0011902)2.56965239
57Alopecia of scalp (HP:0002293)2.54553158
58Hyperammonemia (HP:0001987)2.53044353
59Anonychia (HP:0001798)2.52291626
60Abnormality of glycine metabolism (HP:0010895)2.52108778
61Abnormality of serine family amino acid metabolism (HP:0010894)2.52108778
62Hypoplasia of dental enamel (HP:0006297)2.51696513
63Aplasia cutis congenita (HP:0001057)2.48828410
64Abnormality of the gastric mucosa (HP:0004295)2.48403880
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.48131467
66Gout (HP:0001997)2.43908948
67Nail dystrophy (HP:0008404)2.43122111
68Symptomatic seizures (HP:0011145)2.41559864
69Hyperglycemia (HP:0003074)2.41388199
70Corneal erosion (HP:0200020)2.39925461
71Abnormality of molar (HP:0011077)2.38856208
72Abnormality of molar morphology (HP:0011070)2.38856208
73Dehydration (HP:0001944)2.38779298
74Abnormality of the axillary hair (HP:0100134)2.38557589
75Abnormality of secondary sexual hair (HP:0009888)2.38557589
76Chronic bronchitis (HP:0004469)2.37084796
77Vascular calcification (HP:0004934)2.36307664
78Generalized aminoaciduria (HP:0002909)2.34771878
79Hypercholesterolemia (HP:0003124)2.33238132
80Hypoglycemic seizures (HP:0002173)2.31414239
81Abnormality of purine metabolism (HP:0004352)2.29902826
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28236027
83Abnormality of the dental pulp (HP:0006479)2.26645465
84Pruritus (HP:0000989)2.26404421
85Amelogenesis imperfecta (HP:0000705)2.26402340
86Rickets (HP:0002748)2.26380047
87Laryngomalacia (HP:0001601)2.25363392
88Ventricular tachycardia (HP:0004756)2.24903642
89Flat acetabular roof (HP:0003180)2.24622266
90Blepharitis (HP:0000498)2.23173466
91Amniotic constriction ring (HP:0009775)2.23032140
92Abnormality of placental membranes (HP:0011409)2.23032140
93Carious teeth (HP:0000670)2.22728930
94Sparse eyelashes (HP:0000653)2.22318343
95Erythema (HP:0010783)2.21746584
96Erythroderma (HP:0001019)2.20942879
97Hypoalphalipoproteinemia (HP:0003233)2.20411110
98Late onset (HP:0003584)2.20323527
99Curly hair (HP:0002212)2.19437047
100Advanced eruption of teeth (HP:0006288)2.17561857
101Pancreatitis (HP:0001733)2.17312716
102Abnormality of the neuromuscular junction (HP:0003398)2.16052584
103Fatigable weakness (HP:0003473)2.16052584
104Abdominal distention (HP:0003270)2.15525581
105Proximal tubulopathy (HP:0000114)2.14408089
106Septate vagina (HP:0001153)2.14252582
107* Abnormality of the salivary glands (HP:0010286)2.11703255
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08980583
109Abnormality of proline metabolism (HP:0010907)2.08656674
110Hydroxyprolinuria (HP:0003080)2.08656674
111Acanthosis nigricans (HP:0000956)2.07820502
112Abnormality of complement system (HP:0005339)2.07431715
113Abnormality of oral frenula (HP:0000190)2.05969696
114Hyperhidrosis (HP:0000975)2.04609221
115Cardiovascular calcification (HP:0011915)2.04481346
116Natal tooth (HP:0000695)2.02724282
117Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.01394656
118Hyperbilirubinemia (HP:0002904)2.00674314
119Hyperinsulinemic hypoglycemia (HP:0000825)1.99790768
120* Hypodontia (HP:0000668)1.97246477
121* Pterygium (HP:0001059)1.96688975
122Hyperactive renin-angiotensin system (HP:0000841)1.95952228
123Ectropion (HP:0000656)1.95721138
124Hepatocellular carcinoma (HP:0001402)1.94858950
125Ileus (HP:0002595)1.94690929
126Abnormality of chloride homeostasis (HP:0011422)1.94675108
127Thick nail (HP:0001805)1.94334064
128Abnormality of nucleobase metabolism (HP:0010932)1.94043765
129Conjunctival hamartoma (HP:0100780)1.93931681
130Joint hemorrhage (HP:0005261)1.93914848
131Abnormality of fatty-acid metabolism (HP:0004359)1.93405136
132Abnormality of the distal phalanges of the toes (HP:0010182)1.92615983
133Myocardial infarction (HP:0001658)1.91594414
134Cheilitis (HP:0100825)1.89208644
135Hyperparathyroidism (HP:0000843)1.87930708
136Esophageal varix (HP:0002040)1.86335321
137Xerostomia (HP:0000217)1.85682856
138Hypohidrosis (HP:0000966)1.85166082
139Absent hair (HP:0002298)1.84210551
140Abnormality of vitamin metabolism (HP:0100508)1.83429177
141* Hypoplastic labia majora (HP:0000059)1.83017629
142Abnormality of the fingernails (HP:0001231)1.80343376
143Nasolacrimal duct obstruction (HP:0000579)1.77759724
144Hoarse voice (HP:0001609)1.73535397
145Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73277519
146Short nail (HP:0001799)1.71471289
147Hyperkalemia (HP:0002153)1.68711706
148Rhinitis (HP:0012384)1.68079280
149Abnormal respiratory motile cilium physiology (HP:0012261)1.66047570
150Trismus (HP:0000211)1.64325290
151Neonatal death (HP:0003811)1.63880476
152Corneal dystrophy (HP:0001131)1.63013825
153Follicular hyperkeratosis (HP:0007502)1.62024646
154Distal lower limb muscle weakness (HP:0009053)1.61285439
155Depressed nasal tip (HP:0000437)1.60922365
156Periodontitis (HP:0000704)1.59360714
157* Abnormality of the labia majora (HP:0012881)1.57183031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.74933151
2MST43.49633433
3ERN13.39652051
4MST1R3.30266842
5EPHA23.24738072
6MAP3K23.22253822
7FGFR42.92164463
8MAP3K32.79283881
9MAP3K92.74585858
10LATS12.60447316
11TAOK32.60191795
12MAPK152.55961226
13FER2.55894415
14MAPKAPK32.54907253
15INSRR2.36147541
16BCKDK2.32334543
17EPHA31.97372741
18ARAF1.95314311
19SIK11.82291389
20PTK61.80040929
21LATS21.63038515
22NTRK11.61871528
23CDK121.51263255
24MAP2K21.51084800
25MAP3K121.50138434
26RPS6KB21.49636847
27FGFR21.47710558
28PIK3CG1.47185488
29MET1.42812372
30EPHB21.37858016
31FGFR31.28200793
32WNK41.28196716
33LMTK21.26326244
34AKT31.25615895
35MAP3K131.25599879
36EPHB11.25289742
37STK38L1.23899612
38PAK41.21438816
39TYK21.20247674
40RIPK11.18112298
41MAP3K61.15874950
42SMG11.14135391
43DYRK1B1.14061107
44PTK21.11533829
45ERBB21.09830166
46TRPM71.04706183
47TRIB31.03724882
48STK381.02652334
49NUAK11.01184929
50MAP3K11.00964941
51MAP2K60.96282091
52NEK60.95648869
53PIM20.95227937
54ERBB40.93165485
55LRRK20.92088582
56IRAK30.90986985
57NLK0.89965684
58NEK90.87695623
59FLT30.85759330
60HIPK20.84825166
61STK390.84004181
62MAP3K70.83086048
63BMPR1B0.82868933
64TESK10.82020508
65PRKCI0.81189872
66MAP3K140.79333127
67CDK60.76707446
68TAOK10.76587988
69DDR20.75469964
70STK100.75202508
71STK30.73321293
72ERBB30.72046625
73JAK20.70368941
74WNK30.70039355
75GRK10.69620049
76PKN20.68199585
77KSR20.67072989
78PASK0.64081127
79STK240.63817297
80DMPK0.60786326
81EEF2K0.60346146
82TGFBR10.59809128
83IKBKE0.59653904
84TGFBR20.57622923
85CHUK0.55874429
86PRKD20.55559470
87MAPK110.54112669
88PDGFRA0.54066772
89CDC42BPA0.53846955
90IRAK10.53597113
91JAK10.52496984
92RPS6KA20.50888034
93JAK30.50485521
94PBK0.50277445
95MAP2K10.50009626
96SGK30.49533389
97BRAF0.47415481
98BMX0.47311895
99OXSR10.45800061
100GSK3A0.45309021
101FGFR10.43567754
102SGK4940.41578644
103SGK2230.41578644
104ICK0.41352251
105TBK10.41182603
106NME10.41155286
107PRKAA20.40632075
108ITK0.37968801
109ROCK20.37685302
110RET0.37113699
111RPS6KA40.37046809
112PRKG20.37007349
113BCR0.36166177
114ILK0.35921697
115PDGFRB0.35530413
116MAP2K30.33420543
117PIK3CA0.32648146
118MYLK0.32455410
119RPS6KB10.31572603
120MAPKAPK20.31267410
121PDK20.30266230
122MAPKAPK50.30025450
123MTOR0.29593188
124EIF2AK30.27557839
125SIK30.26519794
126ROCK10.25271785
127WNK10.25102280
128RPS6KA10.23949352
129PRKD30.23790663
130IGF1R0.23221756
131PAK30.23060232
132TIE10.21613932
133PRKD10.21086757
134PRKCZ0.21031342
135ABL20.20963669
136CDK90.20370924
137MAP3K80.19478192
138PRKCE0.18098729
139TTK0.17339036
140RAF10.16859520

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25092779
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.22778278
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.06436469
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.72039171
5Histidine metabolism_Homo sapiens_hsa003402.67209528
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.59591959
7Sulfur metabolism_Homo sapiens_hsa009202.54842932
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.40906762
9Nitrogen metabolism_Homo sapiens_hsa009102.35586977
10Tryptophan metabolism_Homo sapiens_hsa003802.28813778
11Chemical carcinogenesis_Homo sapiens_hsa052042.28786812
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.26099246
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.25212181
14Fat digestion and absorption_Homo sapiens_hsa049752.21524966
15Fatty acid degradation_Homo sapiens_hsa000712.20373803
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02399086
17Phenylalanine metabolism_Homo sapiens_hsa003601.92758562
18Arginine biosynthesis_Homo sapiens_hsa002201.89421473
19Retinol metabolism_Homo sapiens_hsa008301.85467259
20Caffeine metabolism_Homo sapiens_hsa002321.74963947
21Complement and coagulation cascades_Homo sapiens_hsa046101.71995190
22Folate biosynthesis_Homo sapiens_hsa007901.71927822
23beta-Alanine metabolism_Homo sapiens_hsa004101.71635913
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.70205372
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66621988
26Peroxisome_Homo sapiens_hsa041461.66509022
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65790526
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63209856
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62499645
30Small cell lung cancer_Homo sapiens_hsa052221.61418730
31ABC transporters_Homo sapiens_hsa020101.58778590
32Starch and sucrose metabolism_Homo sapiens_hsa005001.47194785
33Tyrosine metabolism_Homo sapiens_hsa003501.46987569
34Butanoate metabolism_Homo sapiens_hsa006501.45674331
35PPAR signaling pathway_Homo sapiens_hsa033201.44557520
36Vitamin digestion and absorption_Homo sapiens_hsa049771.43480640
37Propanoate metabolism_Homo sapiens_hsa006401.39831591
38Bile secretion_Homo sapiens_hsa049761.36153386
39Selenocompound metabolism_Homo sapiens_hsa004501.35716902
40Focal adhesion_Homo sapiens_hsa045101.35545331
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33621100
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29353535
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28829523
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28778968
45Fatty acid metabolism_Homo sapiens_hsa012121.24887578
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.22757188
47Linoleic acid metabolism_Homo sapiens_hsa005911.19697423
48Glutathione metabolism_Homo sapiens_hsa004801.18899881
49Fatty acid elongation_Homo sapiens_hsa000621.11849414
50Proteoglycans in cancer_Homo sapiens_hsa052051.00819387
51Notch signaling pathway_Homo sapiens_hsa043300.98632498
52Protein digestion and absorption_Homo sapiens_hsa049740.98609106
53p53 signaling pathway_Homo sapiens_hsa041150.97739749
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97279860
55Dorso-ventral axis formation_Homo sapiens_hsa043200.95998162
56Staphylococcus aureus infection_Homo sapiens_hsa051500.92185073
57ErbB signaling pathway_Homo sapiens_hsa040120.89679356
58Arachidonic acid metabolism_Homo sapiens_hsa005900.88357441
59Inositol phosphate metabolism_Homo sapiens_hsa005620.85781827
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85091714
61Sulfur relay system_Homo sapiens_hsa041220.84120804
62Sphingolipid metabolism_Homo sapiens_hsa006000.81445442
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78229986
64Endometrial cancer_Homo sapiens_hsa052130.78075087
65Ovarian steroidogenesis_Homo sapiens_hsa049130.77357536
66Glycerolipid metabolism_Homo sapiens_hsa005610.77318383
67Steroid biosynthesis_Homo sapiens_hsa001000.76907978
68Protein export_Homo sapiens_hsa030600.76739245
69Mineral absorption_Homo sapiens_hsa049780.75898939
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75337987
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75040222
72Pyruvate metabolism_Homo sapiens_hsa006200.73944236
73Arginine and proline metabolism_Homo sapiens_hsa003300.73770796
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73166746
75Pancreatic secretion_Homo sapiens_hsa049720.71911877
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71838056
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.71553334
78Insulin signaling pathway_Homo sapiens_hsa049100.68797969
79VEGF signaling pathway_Homo sapiens_hsa043700.67339540
80GnRH signaling pathway_Homo sapiens_hsa049120.65541137
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64780926
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63793349
83Renal cell carcinoma_Homo sapiens_hsa052110.63533267
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62825969
85MicroRNAs in cancer_Homo sapiens_hsa052060.62765414
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.61024201
87Lysine degradation_Homo sapiens_hsa003100.60885424
88Insulin resistance_Homo sapiens_hsa049310.58657537
89Renin secretion_Homo sapiens_hsa049240.57786954
90Renin-angiotensin system_Homo sapiens_hsa046140.57450371
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57092807
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57004877
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56037576
94Galactose metabolism_Homo sapiens_hsa000520.55242234
95Axon guidance_Homo sapiens_hsa043600.53596278
96Toxoplasmosis_Homo sapiens_hsa051450.53524613
97Prostate cancer_Homo sapiens_hsa052150.53480175
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53147495
99Glucagon signaling pathway_Homo sapiens_hsa049220.51421696
100Estrogen signaling pathway_Homo sapiens_hsa049150.49344201
101Bladder cancer_Homo sapiens_hsa052190.49259382
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48757646
103Pancreatic cancer_Homo sapiens_hsa052120.47906094
104Choline metabolism in cancer_Homo sapiens_hsa052310.46196414
105Chronic myeloid leukemia_Homo sapiens_hsa052200.45954407
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45916082
107Adherens junction_Homo sapiens_hsa045200.45499205
108Endocytosis_Homo sapiens_hsa041440.45384575
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45232770
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45087462
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43449038
112Pathways in cancer_Homo sapiens_hsa052000.43344634
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43219827
114Tight junction_Homo sapiens_hsa045300.42664945
115Acute myeloid leukemia_Homo sapiens_hsa052210.42505343
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41330219
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39751913
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.39081575
119Hepatitis C_Homo sapiens_hsa051600.38376410
120Carbon metabolism_Homo sapiens_hsa012000.37486343
121Thyroid cancer_Homo sapiens_hsa052160.35978151
122Fatty acid biosynthesis_Homo sapiens_hsa000610.35556883
123Metabolic pathways_Homo sapiens_hsa011000.33001501
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32135534
125ECM-receptor interaction_Homo sapiens_hsa045120.30169321
126Thyroid hormone synthesis_Homo sapiens_hsa049180.29958996
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.28174985
128Basal cell carcinoma_Homo sapiens_hsa052170.28172294
129Biosynthesis of amino acids_Homo sapiens_hsa012300.25477456
130Amoebiasis_Homo sapiens_hsa051460.24418315
131Circadian rhythm_Homo sapiens_hsa047100.21905581
132Ether lipid metabolism_Homo sapiens_hsa005650.21123625
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.17010251
134Other glycan degradation_Homo sapiens_hsa005110.16119767
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15798077
136Fructose and mannose metabolism_Homo sapiens_hsa000510.15710733
137Hippo signaling pathway_Homo sapiens_hsa043900.14760001
138Prion diseases_Homo sapiens_hsa050200.13892608
139Prolactin signaling pathway_Homo sapiens_hsa049170.09925950

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