IRF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.40473189
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.40473189
3antigen processing and presentation of endogenous antigen (GO:0019883)6.70075675
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.38263225
5* cellular response to type I interferon (GO:0071357)6.28790349
6* type I interferon signaling pathway (GO:0060337)6.28790349
7* response to type I interferon (GO:0034340)6.26392397
8response to interferon-alpha (GO:0035455)5.50342917
9* positive regulation of interferon-alpha production (GO:0032727)4.87483532
10* regulation of interferon-alpha production (GO:0032647)4.60494429
11cellular response to interferon-alpha (GO:0035457)4.58854256
12positive regulation of gamma-delta T cell activation (GO:0046645)4.51399271
13negative regulation of viral genome replication (GO:0045071)4.50743448
14response to interferon-beta (GO:0035456)4.46255984
15negative regulation of interleukin-12 production (GO:0032695)4.44489597
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38976416
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.38976416
18modulation by symbiont of host immune response (GO:0052553)4.38976416
19positive regulation by symbiont of host defense response (GO:0052509)4.38976416
20modulation by symbiont of host defense response (GO:0052031)4.38976416
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38976416
22* interferon-gamma-mediated signaling pathway (GO:0060333)4.32744717
23detection of bacterium (GO:0016045)4.28825873
24detection of other organism (GO:0098543)4.27251186
25* positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.21570204
26regulation of interferon-beta biosynthetic process (GO:0045357)4.16012953
27cellular response to interferon-beta (GO:0035458)4.11987211
28* regulation of type I interferon-mediated signaling pathway (GO:0060338)4.01100503
29antigen processing and presentation via MHC class Ib (GO:0002475)3.96531327
30T cell migration (GO:0072678)3.91814245
31positive regulation of antigen processing and presentation (GO:0002579)3.76498128
32regulation of RIG-I signaling pathway (GO:0039535)3.66594920
33positive regulation of type 2 immune response (GO:0002830)3.64650380
34response to peptidoglycan (GO:0032494)3.59606583
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58474268
36germinal center formation (GO:0002467)3.57786657
37negative regulation of cytokine production involved in immune response (GO:0002719)3.56555793
38* immunoglobulin mediated immune response (GO:0016064)3.56257995
39regulation of response to interferon-gamma (GO:0060330)3.55733103
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.51830560
41* cellular response to interferon-gamma (GO:0071346)3.45854018
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44770123
43detection of external biotic stimulus (GO:0098581)3.43137978
44negative regulation of T cell mediated immunity (GO:0002710)3.42552146
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.42091563
46defense response to virus (GO:0051607)3.36531754
47regulation of B cell receptor signaling pathway (GO:0050855)3.36341796
48neutrophil activation involved in immune response (GO:0002283)3.36242581
49cellular response to exogenous dsRNA (GO:0071360)3.35288075
50regulation of antigen processing and presentation (GO:0002577)3.34467868
51positive regulation of natural killer cell differentiation (GO:0032825)3.30305846
52NIK/NF-kappaB signaling (GO:0038061)3.29114599
53* positive regulation of interferon-beta production (GO:0032728)3.28925975
54respiratory burst (GO:0045730)3.27897422
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26785966
56response to host immune response (GO:0052572)3.26785966
57regulation of gamma-delta T cell activation (GO:0046643)3.25945380
58regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.24256519
59regulation of type 2 immune response (GO:0002828)3.24157099
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.22400776
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22065945
62* response to interferon-gamma (GO:0034341)3.21649905
63regulation of gamma-delta T cell differentiation (GO:0045586)3.21380865
64defense response to protozoan (GO:0042832)3.19113958
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16296225
66T-helper 1 type immune response (GO:0042088)3.15231460
67response to muramyl dipeptide (GO:0032495)3.15062767
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11312227
69myeloid cell activation involved in immune response (GO:0002275)3.10977136
70lymphocyte chemotaxis (GO:0048247)3.10750414
71regulation of interleukin-12 biosynthetic process (GO:0045075)3.09143042
72macrophage activation involved in immune response (GO:0002281)3.08284946
73myeloid dendritic cell differentiation (GO:0043011)3.08253790
74negative regulation of innate immune response (GO:0045824)3.07782393
75positive regulation of humoral immune response (GO:0002922)3.06812065
76regulation of T-helper 1 cell differentiation (GO:0045625)3.06613694
77leukocyte aggregation (GO:0070486)3.05512894
78regulation of MHC class I biosynthetic process (GO:0045343)3.02181158
79detection of biotic stimulus (GO:0009595)3.01122022
80negative regulation of leukocyte mediated immunity (GO:0002704)3.00567210
81natural killer cell mediated cytotoxicity (GO:0042267)2.99658980
82natural killer cell mediated immunity (GO:0002228)2.99658980
83regulation of interleukin-12 production (GO:0032655)2.98751670
84B cell receptor signaling pathway (GO:0050853)2.98219856
85regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.97365115
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94807437
87positive regulation of interleukin-12 production (GO:0032735)2.93714995
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93502100
89response to host (GO:0075136)2.93502100
90response to host defenses (GO:0052200)2.93502100
91neutrophil activation (GO:0042119)2.93438190
92negative regulation of type 2 immune response (GO:0002829)2.92316501
93detection of molecule of bacterial origin (GO:0032490)2.92106378
94myeloid dendritic cell activation (GO:0001773)2.90063696
95positive regulation of chemokine biosynthetic process (GO:0045080)2.89934340
96* B cell mediated immunity (GO:0019724)2.88799499
97response to protozoan (GO:0001562)2.87881063
98tolerance induction (GO:0002507)2.87783908
99regulation of T-helper 2 cell differentiation (GO:0045628)2.87738272
100positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86412082
101positive thymic T cell selection (GO:0045059)2.85522712
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85372826
103negative thymic T cell selection (GO:0045060)2.84041894
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83859536
105positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.82254420
106regulation of tolerance induction (GO:0002643)2.82242713
107regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81685984
108negative regulation of viral process (GO:0048525)2.81008746
109negative regulation of production of molecular mediator of immune response (GO:0002701)2.79225299
110regulation of T cell mediated cytotoxicity (GO:0001914)2.77810455
111natural killer cell activation involved in immune response (GO:0002323)2.77502230
112regulation of T cell tolerance induction (GO:0002664)2.76279542
113regulation of alpha-beta T cell proliferation (GO:0046640)2.75710919
114positive regulation of B cell differentiation (GO:0045579)2.75507177
115cellular response to zinc ion (GO:0071294)2.74885478
116macrophage activation (GO:0042116)2.74816767
117negative regulation of type I interferon production (GO:0032480)2.74042165
118mature B cell differentiation involved in immune response (GO:0002313)2.73995513
119regulation of cytokine secretion involved in immune response (GO:0002739)2.72960250
120negative T cell selection (GO:0043383)2.72281202
121regulation of viral genome replication (GO:0045069)2.71468028
122lymphocyte migration (GO:0072676)2.65454664
123JAK-STAT cascade (GO:0007259)2.64764314
124positive regulation of response to biotic stimulus (GO:0002833)2.62965536
125positive regulation of cAMP-mediated signaling (GO:0043950)2.62915197
126granulocyte activation (GO:0036230)2.62527324
127cellular extravasation (GO:0045123)2.62300515
128positive regulation of interleukin-17 production (GO:0032740)2.61831513
129negative regulation of cell killing (GO:0031342)2.61753300
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61753300
131regulation of chemokine biosynthetic process (GO:0045073)2.59674540
132dendritic cell differentiation (GO:0097028)2.59397649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.79897645
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.41921106
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.10530343
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.91700593
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10794767
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.57695575
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28935573
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.10084832
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08460625
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00848662
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.94560599
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80050693
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79305406
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.72410941
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55494977
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.45536500
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38239248
18GATA1_22025678_ChIP-Seq_K562_Human2.15444131
19* MAF_26560356_Chip-Seq_TH1_Human2.14692123
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10562369
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05705971
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04528310
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02602868
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02556567
25MYB_26560356_Chip-Seq_TH2_Human1.99774014
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96059171
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88411768
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82405683
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75682857
30MYB_26560356_Chip-Seq_TH1_Human1.73724009
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72650385
32RUNX_20019798_ChIP-Seq_JUKART_Human1.72407333
33* SPI1_23547873_ChIP-Seq_NB4_Human1.71738539
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71364788
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.68126370
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.59082513
37UTX_26944678_Chip-Seq_JUKART_Human1.57609857
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.55875804
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54565255
40VDR_24763502_ChIP-Seq_THP-1_Human1.54344817
41VDR_21846776_ChIP-Seq_THP-1_Human1.51174882
42SCL_19346495_ChIP-Seq_HPC-7_Human1.48141237
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47934709
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46080089
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41803261
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40622325
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39393205
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39050646
49PU_27001747_Chip-Seq_BMDM_Mouse1.38619559
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35436536
51* SPI1_23127762_ChIP-Seq_K562_Human1.32669942
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32266501
53* MAF_26560356_Chip-Seq_TH2_Human1.30289200
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.29818559
55GATA3_27048872_Chip-Seq_THYMUS_Human1.26292867
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25312672
57* BCL6_27268052_Chip-Seq_Bcells_Human1.24643346
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23586133
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.22095061
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.20805322
61MYC_22102868_ChIP-Seq_BL_Human1.20260688
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18646310
63* BCOR_27268052_Chip-Seq_Bcells_Human1.17198179
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14864663
65TCF7_22412390_ChIP-Seq_EML_Mouse1.13622178
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13215121
67* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12780702
68EGR1_19032775_ChIP-ChIP_M12_Human1.11475546
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11368133
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.10138755
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08110709
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06915615
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06389844
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05995775
75GATA3_26560356_Chip-Seq_TH2_Human1.05325103
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03354816
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03014261
78RACK7_27058665_Chip-Seq_MCF-7_Human1.02100602
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00759909
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.00395645
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98866875
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98831831
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97495831
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95838332
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95308111
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95221805
87VDR_24787735_ChIP-Seq_THP-1_Human0.94868049
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94369026
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93867819
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93724790
91NCOR1_26117541_ChIP-Seq_K562_Human0.92309680
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91813824
93LXR_22292898_ChIP-Seq_THP-1_Human0.91106021
94* KDM2B_26808549_Chip-Seq_DND41_Human0.90226871
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89603954
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89145246
97* SA1_27219007_Chip-Seq_ERYTHROID_Human0.88438495
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86945763
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.86017198
100* P68_20966046_ChIP-Seq_HELA_Human0.83936908
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83420070
102* SOX2_20726797_ChIP-Seq_SW620_Human0.83069245
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82680294
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.81161220
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79341363
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78683764
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.78581975
108P300_27268052_Chip-Seq_Bcells_Human0.77495414
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77399560
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76554392
111TRIM28_21343339_ChIP-Seq_HEK293_Human0.76227179
112PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74862462
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73222537
114GATA1_19941826_ChIP-Seq_K562_Human0.69790222
115GATA2_19941826_ChIP-Seq_K562_Human0.68832946
116SPI1_20517297_ChIP-Seq_HL60_Human0.68479069
117* CTCF_26484167_Chip-Seq_Bcells_Mouse0.67275066
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66144548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.51892680
2MP0009785_altered_susceptibility_to4.09502397
3MP0003724_increased_susceptibility_to3.49765827
4MP0000685_abnormal_immune_system3.22605506
5MP0005671_abnormal_response_to3.13246670
6MP0003436_decreased_susceptibility_to3.08919687
7MP0001790_abnormal_immune_system3.06201842
8MP0005387_immune_system_phenotype3.06201842
9MP0006082_CNS_inflammation3.05363355
10* MP0005025_abnormal_response_to3.00815014
11MP0005000_abnormal_immune_tolerance2.85224439
12MP0002148_abnormal_hypersensitivity_rea2.81294710
13MP0004510_myositis2.74862693
14MP0003303_peritoneal_inflammation2.70602373
15MP0001800_abnormal_humoral_immune2.65687728
16MP0002419_abnormal_innate_immunity2.59510910
17MP0002166_altered_tumor_susceptibility2.51544844
18* MP0002723_abnormal_immune_serum2.49443809
19MP0002452_abnormal_antigen_presenting2.48882065
20MP0004947_skin_inflammation2.30174006
21* MP0001819_abnormal_immune_cell2.24301180
22* MP0002420_abnormal_adaptive_immunity2.21064745
23MP0002006_tumorigenesis2.16916007
24MP0005058_abnormal_lysosome_morphology2.01342371
25MP0009840_abnormal_foam_cell1.99383430
26MP0010155_abnormal_intestine_physiology1.97060972
27MP0003191_abnormal_cellular_cholesterol1.96577609
28MP0001533_abnormal_skeleton_physiology1.91807997
29MP0003300_gastrointestinal_ulcer1.86602867
30MP0001845_abnormal_inflammatory_respons1.85856402
31MP0005464_abnormal_platelet_physiology1.82583816
32* MP0008469_abnormal_protein_level1.81869958
33MP0002405_respiratory_system_inflammati1.81757901
34MP0003763_abnormal_thymus_physiology1.80001497
35MP0005451_abnormal_body_composition1.74402268
36MP0001853_heart_inflammation1.73914199
37MP0000716_abnormal_immune_system1.73906025
38MP0002398_abnormal_bone_marrow1.71408773
39MP0009333_abnormal_splenocyte_physiolog1.67995549
40MP0009764_decreased_sensitivity_to1.66697758
41MP0002138_abnormal_hepatobiliary_system1.65680696
42MP0000343_altered_response_to1.62152366
43MP0003448_altered_tumor_morphology1.61732835
44MP0005310_abnormal_salivary_gland1.45194522
45MP0002429_abnormal_blood_cell1.41138895
46MP0000689_abnormal_spleen_morphology1.38838313
47MP0002722_abnormal_immune_system1.36131114
48MP0005360_urolithiasis1.32904589
49MP0000858_altered_metastatic_potential1.29683537
50MP0002933_joint_inflammation1.22208813
51MP0001873_stomach_inflammation1.21951277
52MP0008260_abnormal_autophagy1.21334418
53MP0000604_amyloidosis1.20407881
54MP0002998_abnormal_bone_remodeling1.20351842
55MP0003806_abnormal_nucleotide_metabolis1.19638746
56MP0009278_abnormal_bone_marrow1.18854536
57MP0003075_altered_response_to1.17963364
58MP0001545_abnormal_hematopoietic_system1.17900563
59MP0005397_hematopoietic_system_phenotyp1.17900563
60MP0009763_increased_sensitivity_to1.12253794
61MP0005083_abnormal_biliary_tract1.08834815
62MP0002254_reproductive_system_inflammat1.04802047
63MP0003453_abnormal_keratinocyte_physiol1.04739846
64MP0002332_abnormal_exercise_endurance1.04414564
65MP0008004_abnormal_stomach_pH1.04126652
66MP0004782_abnormal_surfactant_physiolog1.03085316
67MP0003172_abnormal_lysosome_physiology1.00849363
68MP0003690_abnormal_glial_cell0.96408970
69MP0001851_eye_inflammation0.95729635
70MP0005023_abnormal_wound_healing0.95349785
71MP0003866_abnormal_defecation0.93587248
72MP0001663_abnormal_digestive_system0.93520451
73MP0002139_abnormal_hepatobiliary_system0.93156823
74MP0000609_abnormal_liver_physiology0.92414689
75MP0005166_decreased_susceptibility_to0.92257633
76MP0005167_abnormal_blood-brain_barrier0.91837896
77MP0003186_abnormal_redox_activity0.91823392
78MP0003045_fibrosis0.88764861
79MP0000703_abnormal_thymus_morphology0.88434632
80MP0000249_abnormal_blood_vessel0.85585703
81MP0004883_abnormal_blood_vessel0.84594068
82MP0005390_skeleton_phenotype0.81205990
83MP0005164_abnormal_response_to0.80974976
84MP0000465_gastrointestinal_hemorrhage0.74371079
85MP0004858_abnormal_nervous_system0.73241943
86MP0010307_abnormal_tumor_latency0.72888333
87MP0005319_abnormal_enzyme/_coenzyme0.72161828
88MP0002136_abnormal_kidney_physiology0.72002136
89MP0003183_abnormal_peptide_metabolism0.71809200
90MP0008874_decreased_physiological_sensi0.71242774
91MP0003566_abnormal_cell_adhesion0.71153619
92MP0002396_abnormal_hematopoietic_system0.69342794
93MP0003091_abnormal_cell_migration0.68791151
94MP0001958_emphysema0.67685248
95MP0002132_abnormal_respiratory_system0.67101831
96MP0004808_abnormal_hematopoietic_stem0.66537224
97MP0001881_abnormal_mammary_gland0.66298173
98MP0005584_abnormal_enzyme/coenzyme_acti0.65925469
99MP0002277_abnormal_respiratory_mucosa0.64074656
100MP0010329_abnormal_lipoprotein_level0.64034645
101MP0005076_abnormal_cell_differentiation0.63976585
102MP0009765_abnormal_xenobiotic_induced0.63693337
103MP0003828_pulmonary_edema0.62923257
104MP0009643_abnormal_urine_homeostasis0.62908101
105MP0003795_abnormal_bone_structure0.62312835
106MP0003252_abnormal_bile_duct0.62001133
107MP0010234_abnormal_vibrissa_follicle0.61194475
108MP0001348_abnormal_lacrimal_gland0.61132340
109MP0003656_abnormal_erythrocyte_physiolo0.60916343
110MP0000598_abnormal_liver_morphology0.60402668
111MP0006054_spinal_hemorrhage0.59541863
112MP0000490_abnormal_crypts_of0.59458359
113MP0002693_abnormal_pancreas_physiology0.56317334
114MP0005165_increased_susceptibility_to0.55581658
115MP0005381_digestive/alimentary_phenotyp0.54389640
116MP0005535_abnormal_body_temperature0.50390899
117MP0002019_abnormal_tumor_incidence0.49824635
118MP0001542_abnormal_bone_strength0.49694267

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.92364012
2Elevated erythrocyte sedimentation rate (HP:0003565)5.77567943
3Chronic otitis media (HP:0000389)5.51058738
4Recurrent abscess formation (HP:0002722)5.33601475
5Recurrent bacterial skin infections (HP:0005406)4.75100792
6Myositis (HP:0100614)4.61051633
7Recurrent gram-negative bacterial infections (HP:0005420)4.51201281
8Autoimmune thrombocytopenia (HP:0001973)4.47214832
9Nasal polyposis (HP:0100582)4.39388501
10Abnormality of the nasal mucosa (HP:0000433)4.31295680
11Orchitis (HP:0100796)4.13213294
12Systemic lupus erythematosus (HP:0002725)4.08048792
13Abnormality of macrophages (HP:0004311)4.03193635
14Recurrent fungal infections (HP:0002841)3.96327830
15Recurrent bronchitis (HP:0002837)3.90047530
16Increased IgM level (HP:0003496)3.72756114
17Recurrent skin infections (HP:0001581)3.69744952
18Optic neuritis (HP:0100653)3.63707967
19Retrobulbar optic neuritis (HP:0100654)3.63707967
20Recurrent viral infections (HP:0004429)3.61753804
21Recurrent cutaneous fungal infections (HP:0011370)3.56579320
22Chronic mucocutaneous candidiasis (HP:0002728)3.56579320
23Vasculitis (HP:0002633)3.50390961
24Interstitial pulmonary disease (HP:0006530)3.47962938
25Mediastinal lymphadenopathy (HP:0100721)3.42634081
26Stomatitis (HP:0010280)3.41096409
27Abnormality of glycolipid metabolism (HP:0010969)3.37696274
28Abnormality of liposaccharide metabolism (HP:0010968)3.37696274
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.37696274
30Encephalitis (HP:0002383)3.31334924
31Autoimmune hemolytic anemia (HP:0001890)3.30102935
32Hypergammaglobulinemia (HP:0010702)3.26419467
33Gastrointestinal stroma tumor (HP:0100723)3.25881113
34Agammaglobulinemia (HP:0004432)3.22309598
35Basal ganglia calcification (HP:0002135)3.18628898
36Gingivitis (HP:0000230)3.13358569
37Vacuolated lymphocytes (HP:0001922)3.06968573
38Chronic sinusitis (HP:0011109)3.05311386
39Pustule (HP:0200039)2.98773976
40Increased cerebral lipofuscin (HP:0011813)2.98417372
41Hemoptysis (HP:0002105)2.80820715
42Colitis (HP:0002583)2.79783774
43Abnormality of T cell number (HP:0011839)2.76833726
44Loss of speech (HP:0002371)2.74004346
45Pulmonary infiltrates (HP:0002113)2.72846175
46Abnormality of B cell number (HP:0010975)2.70858946
47Increased IgE level (HP:0003212)2.69649216
48Chronic obstructive pulmonary disease (HP:0006510)2.68092656
49Obstructive lung disease (HP:0006536)2.68092656
50Leukocytosis (HP:0001974)2.66736044
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.65840780
52Tetraparesis (HP:0002273)2.65616169
53Panhypogammaglobulinemia (HP:0003139)2.63614352
54Spontaneous hematomas (HP:0007420)2.60181318
55B lymphocytopenia (HP:0010976)2.59290724
56Gangrene (HP:0100758)2.57525289
57Recurrent pneumonia (HP:0006532)2.55344848
58Urticaria (HP:0001025)2.54824737
59Abnormality of T cells (HP:0002843)2.54582936
60Abnormality of the pleura (HP:0002103)2.52542622
61T lymphocytopenia (HP:0005403)2.51635235
62Inflammation of the large intestine (HP:0002037)2.51473920
63Petechiae (HP:0000967)2.49938619
64Gingival bleeding (HP:0000225)2.49133355
65Hematochezia (HP:0002573)2.49027468
66Abnormality of T cell physiology (HP:0011840)2.47821513
67Keratoconjunctivitis sicca (HP:0001097)2.44985093
68Cellulitis (HP:0100658)2.43841148
69Periodontitis (HP:0000704)2.42173527
70Chest pain (HP:0100749)2.41403570
71Meningitis (HP:0001287)2.39080232
72Myocardial infarction (HP:0001658)2.38914446
73Sepsis (HP:0100806)2.38447961
74Gastrointestinal infarctions (HP:0005244)2.38379469
75Arterial thrombosis (HP:0004420)2.38051201
76Gastrointestinal inflammation (HP:0004386)2.36419965
77Eosinophilia (HP:0001880)2.35886366
78Joint swelling (HP:0001386)2.35232847
79Recurrent sinusitis (HP:0011108)2.33527199
80Porencephaly (HP:0002132)2.33382116
81Glomerulonephritis (HP:0000099)2.32245389
82Combined immunodeficiency (HP:0005387)2.30986182
83Severe combined immunodeficiency (HP:0004430)2.30871951
84Recurrent lower respiratory tract infections (HP:0002783)2.29908278
85IgA deficiency (HP:0002720)2.29479546
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.29375565
87Purpura (HP:0000979)2.29319571
88Abnormality of eosinophils (HP:0001879)2.28620000
89Lymphopenia (HP:0001888)2.28124877
90Emphysema (HP:0002097)2.27461264
91Keratoconjunctivitis (HP:0001096)2.24595105
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.23941646
93Restrictive lung disease (HP:0002091)2.23766480
94Nephritis (HP:0000123)2.22547776
95Chronic diarrhea (HP:0002028)2.20227504
96Anorexia (HP:0002039)2.20164186
97IgG deficiency (HP:0004315)2.18404546
98Cheilitis (HP:0100825)2.16910262
99Bronchitis (HP:0012387)2.16376115
100Episodic fever (HP:0001954)2.15633662
101Dysostosis multiplex (HP:0000943)2.15549587
102Prolonged bleeding time (HP:0003010)2.11910944
103Skin ulcer (HP:0200042)2.11406749
104Abnormality of the pericardium (HP:0001697)2.10661273
105Malnutrition (HP:0004395)2.10517592
106Premature loss of primary teeth (HP:0006323)2.10374146
107Disinhibition (HP:0000734)2.10299328
108Arthralgia (HP:0002829)2.10287316
109Complement deficiency (HP:0004431)2.10053537
110Osteomyelitis (HP:0002754)2.05923417
111Granulocytopenia (HP:0001913)2.05815677
112Hypertensive crisis (HP:0100735)2.05167397
113Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05116844
114Hepatosplenomegaly (HP:0001433)2.04650033
115Abnormality of the peritoneum (HP:0002585)2.04578932
116IgM deficiency (HP:0002850)2.04327560
117Increased serum ferritin (HP:0003281)2.03365451
118Epistaxis (HP:0000421)2.02697022
119Polyneuropathy (HP:0001271)2.02641100
120Joint hemorrhage (HP:0005261)2.00643095
121Thyroiditis (HP:0100646)1.99473743
122Pulmonary embolism (HP:0002204)1.97139129
123Amyloidosis (HP:0011034)1.95236283
124Esophageal varix (HP:0002040)1.94719164
125Axonal loss (HP:0003447)1.94175514
126Thick nail (HP:0001805)1.93395457
127Urinary glycosaminoglycan excretion (HP:0003541)1.92355601
128Mucopolysacchariduria (HP:0008155)1.92355601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.75893006
2FGFR44.23954946
3MAP3K143.53878244
4KIT3.52012434
5JAK33.24197464
6* TBK13.23268483
7MAP4K13.17927624
8* IKBKE3.17309034
9JAK12.99789735
10BLK2.78465405
11ERN12.78463366
12PRPF4B2.56709190
13TXK2.50216977
14FGFR32.25422127
15IRAK42.18959505
16EPHB12.00834468
17ZAP701.93470759
18IKBKB1.93296933
19TAOK21.83768898
20KDR1.80655931
21TAOK11.74852699
22TNK21.72907432
23CSK1.72826680
24EPHA31.71687155
25MAP3K131.69355138
26GRK71.61984344
27IRAK31.60603080
28PIM21.50110134
29NME21.44727963
30RIPK41.37659941
31PBK1.36484719
32LCK1.35536809
33HCK1.33767453
34CSF1R1.26728540
35SYK1.26133441
36BTK1.21210965
37JAK21.21112857
38CHUK1.20672063
39TEC1.19673530
40BMPR21.12930141
41TGFBR21.10686697
42MST41.09881413
43MOS1.06447784
44TAOK31.06380075
45CDC42BPA1.06252583
46NLK1.05852240
47FES1.01254994
48RPS6KA41.00497558
49ITK0.97924053
50SMG10.95459176
51STK100.92986556
52LYN0.92557893
53PTK60.85200400
54LRRK20.84816798
55MAPK110.83350267
56FLT30.83024315
57IRAK10.82345801
58SIK20.80791717
59GRK60.79976861
60TESK20.79958747
61TRIB30.79895463
62IRAK20.79111264
63DDR20.77216825
64MATK0.76967064
65FGR0.72295617
66MAP3K110.68875465
67MAP3K100.64611714
68PIM10.63770402
69NEK90.61399380
70BMX0.60990033
71MARK20.60577612
72PRKD20.60177048
73MAPK70.60171013
74MAP2K30.59753479
75PKN20.59721544
76RIPK10.59240261
77TESK10.58263187
78EGFR0.56648885
79KSR20.54824861
80MARK30.53598126
81MAP3K10.53105152
82SIK10.52206307
83ABL10.51847232
84PRKCD0.51692552
85ABL20.51493416
86MAP3K50.48919553
87TGFBR10.48618405
88MAP3K30.48355333
89DAPK30.47200702
90PRKCQ0.46945167
91MAP3K120.46773632
92MST1R0.46388663
93TTN0.45934973
94RPS6KA50.45837155
95MAP2K60.43179911
96CDK40.43047224
97PRKG20.42642158
98MAPK120.42457779
99MAP3K80.42214586
100EIF2AK20.42138476
101SIK30.40346878
102PRKCH0.39447376
103RPS6KC10.37271698
104RPS6KL10.37271698
105DYRK1B0.35705152
106ADRBK20.33454862
107TIE10.33188003
108FYN0.32441051
109MAPKAPK20.30827185
110IGF1R0.29951127
111RPS6KA60.28562782
112TLK10.28089984
113INSR0.25766777
114MAPK40.25412392
115YES10.24027305
116STK40.23438319
117PDK10.23145967
118SRC0.22825577
119PAK40.22281465
120MAP3K60.21470637
121HIPK20.20182669
122CDK60.16859016
123PDPK10.16797384
124ARAF0.16459271
125MAPK30.15654938

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17415655
2Staphylococcus aureus infection_Homo sapiens_hsa051503.02898588
3* Measles_Homo sapiens_hsa051622.74796062
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.69161500
5* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.68762543
6Primary immunodeficiency_Homo sapiens_hsa053402.64913784
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.64138360
8* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61778274
9Allograft rejection_Homo sapiens_hsa053302.41915048
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37496722
11Graft-versus-host disease_Homo sapiens_hsa053322.32097149
12Antigen processing and presentation_Homo sapiens_hsa046122.30038151
13Osteoclast differentiation_Homo sapiens_hsa043802.28596309
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.24000314
15* Influenza A_Homo sapiens_hsa051642.10052458
16Malaria_Homo sapiens_hsa051442.03649882
17Caffeine metabolism_Homo sapiens_hsa002322.02330827
18Pertussis_Homo sapiens_hsa051332.00906112
19* Herpes simplex infection_Homo sapiens_hsa051681.96832480
20Legionellosis_Homo sapiens_hsa051341.95829120
21Toxoplasmosis_Homo sapiens_hsa051451.84457890
22TNF signaling pathway_Homo sapiens_hsa046681.78146364
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72390451
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71616098
25Tuberculosis_Homo sapiens_hsa051521.71038584
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.63386047
27B cell receptor signaling pathway_Homo sapiens_hsa046621.61905922
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54738955
29Hematopoietic cell lineage_Homo sapiens_hsa046401.54367537
30* Hepatitis C_Homo sapiens_hsa051601.41381263
31Asthma_Homo sapiens_hsa053101.40174918
32Viral myocarditis_Homo sapiens_hsa054161.39968110
33African trypanosomiasis_Homo sapiens_hsa051431.37942231
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36938558
35Chemokine signaling pathway_Homo sapiens_hsa040621.33693326
36Shigellosis_Homo sapiens_hsa051311.33210732
37Apoptosis_Homo sapiens_hsa042101.32599988
38Salmonella infection_Homo sapiens_hsa051321.32437441
39T cell receptor signaling pathway_Homo sapiens_hsa046601.31068356
40Lysosome_Homo sapiens_hsa041421.28938113
41Rheumatoid arthritis_Homo sapiens_hsa053231.23018346
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19580177
43Complement and coagulation cascades_Homo sapiens_hsa046101.15151963
44* Hepatitis B_Homo sapiens_hsa051611.14180940
45Autoimmune thyroid disease_Homo sapiens_hsa053201.11466248
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07470931
47Systemic lupus erythematosus_Homo sapiens_hsa053221.04294928
48Other glycan degradation_Homo sapiens_hsa005111.02420855
49Type I diabetes mellitus_Homo sapiens_hsa049401.02350078
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02222525
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.01933522
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.00127930
53Acute myeloid leukemia_Homo sapiens_hsa052210.91280394
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89778705
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86891519
56Phagosome_Homo sapiens_hsa041450.81758823
57Prolactin signaling pathway_Homo sapiens_hsa049170.78202048
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78125674
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77958691
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.74150458
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.71246059
62Pancreatic cancer_Homo sapiens_hsa052120.68299621
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66289755
64Amoebiasis_Homo sapiens_hsa051460.66017626
65Arginine biosynthesis_Homo sapiens_hsa002200.65114150
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64242112
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52390370
68ABC transporters_Homo sapiens_hsa020100.51839962
69Bladder cancer_Homo sapiens_hsa052190.51230900
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50766542
71Platelet activation_Homo sapiens_hsa046110.50116942
72Epstein-Barr virus infection_Homo sapiens_hsa051690.49876557
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49033296
74Chronic myeloid leukemia_Homo sapiens_hsa052200.48938104
75Small cell lung cancer_Homo sapiens_hsa052220.46205450
76Prion diseases_Homo sapiens_hsa050200.45085189
77Non-small cell lung cancer_Homo sapiens_hsa052230.42014096
78Sulfur relay system_Homo sapiens_hsa041220.41934301
79Mineral absorption_Homo sapiens_hsa049780.39915861
80HIF-1 signaling pathway_Homo sapiens_hsa040660.39853072
81VEGF signaling pathway_Homo sapiens_hsa043700.39529629
82PPAR signaling pathway_Homo sapiens_hsa033200.38470878
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37150644
84* Viral carcinogenesis_Homo sapiens_hsa052030.35861233
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34630002
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34061041
87Type II diabetes mellitus_Homo sapiens_hsa049300.33512637
88Notch signaling pathway_Homo sapiens_hsa043300.33245438
89HTLV-I infection_Homo sapiens_hsa051660.31157183
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30485575
91Insulin resistance_Homo sapiens_hsa049310.29896134
92Histidine metabolism_Homo sapiens_hsa003400.29894909
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29735327
94Folate biosynthesis_Homo sapiens_hsa007900.29599286
95Peroxisome_Homo sapiens_hsa041460.29306224
96Proteasome_Homo sapiens_hsa030500.28901824
97Tryptophan metabolism_Homo sapiens_hsa003800.28397081
98Pentose phosphate pathway_Homo sapiens_hsa000300.27704515
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27102481
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.24777846
101FoxO signaling pathway_Homo sapiens_hsa040680.23659518
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.21306083
103Renal cell carcinoma_Homo sapiens_hsa052110.20908730
104Endocytosis_Homo sapiens_hsa041440.20834296
105Fructose and mannose metabolism_Homo sapiens_hsa000510.20601573
106MAPK signaling pathway_Homo sapiens_hsa040100.20591502
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.17021852
108Fat digestion and absorption_Homo sapiens_hsa049750.15851856
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14939599
110GnRH signaling pathway_Homo sapiens_hsa049120.13405109
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12590755
112Starch and sucrose metabolism_Homo sapiens_hsa005000.12416243
113Galactose metabolism_Homo sapiens_hsa000520.11560309
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11383726
115Dorso-ventral axis formation_Homo sapiens_hsa043200.11376568
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10689359
117mTOR signaling pathway_Homo sapiens_hsa041500.10040107
118Collecting duct acid secretion_Homo sapiens_hsa049660.09210437
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08545155
120Sphingolipid metabolism_Homo sapiens_hsa006000.07661890
121Prostate cancer_Homo sapiens_hsa052150.06010415

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