IRF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.23663222
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.89522293
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.89522293
4positive regulation of gamma-delta T cell activation (GO:0046645)4.81842978
5regulation of B cell receptor signaling pathway (GO:0050855)4.74311447
6regulation of interferon-beta biosynthetic process (GO:0045357)4.33093287
7neutrophil activation involved in immune response (GO:0002283)4.17240822
8cellular response to zinc ion (GO:0071294)4.16002142
9B cell receptor signaling pathway (GO:0050853)4.13034587
10positive regulation of B cell differentiation (GO:0045579)4.11849006
11positive regulation of interferon-alpha production (GO:0032727)4.09288231
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05794760
13immunoglobulin mediated immune response (GO:0016064)4.05134406
14regulation of B cell differentiation (GO:0045577)4.02544918
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00690683
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.00690683
17modulation by symbiont of host immune response (GO:0052553)4.00690683
18positive regulation by symbiont of host defense response (GO:0052509)4.00690683
19modulation by symbiont of host defense response (GO:0052031)4.00690683
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00690683
21cellular response to exogenous dsRNA (GO:0071360)3.96968107
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95422257
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.93578347
24negative regulation of interleukin-12 production (GO:0032695)3.91434349
25positive regulation of type 2 immune response (GO:0002830)3.90287650
26NIK/NF-kappaB signaling (GO:0038061)3.89073858
27regulation of interferon-alpha production (GO:0032647)3.86637748
28cellular response to interferon-beta (GO:0035458)3.83553998
29detection of other organism (GO:0098543)3.83450076
30myeloid dendritic cell activation (GO:0001773)3.82422204
31positive regulation of antigen processing and presentation (GO:0002579)3.81805164
32detection of bacterium (GO:0016045)3.81469120
33myeloid dendritic cell differentiation (GO:0043011)3.72256358
34regulation of alpha-beta T cell proliferation (GO:0046640)3.63591606
35neutrophil activation (GO:0042119)3.63028140
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59194438
37negative regulation of phagocytosis (GO:0050765)3.57811331
38respiratory burst (GO:0045730)3.55477000
39* response to type I interferon (GO:0034340)3.54975691
40* type I interferon signaling pathway (GO:0060337)3.54031752
41* cellular response to type I interferon (GO:0071357)3.54031752
42T-helper 1 type immune response (GO:0042088)3.47787529
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46494245
44granulocyte activation (GO:0036230)3.45097516
45regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43288139
46* interferon-gamma-mediated signaling pathway (GO:0060333)3.42281671
47macrophage activation involved in immune response (GO:0002281)3.42258363
48regulation of antigen processing and presentation (GO:0002577)3.40338653
49regulation of gamma-delta T cell differentiation (GO:0045586)3.36718187
50positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.36659199
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35941801
52interferon-gamma production (GO:0032609)3.33875809
53B cell proliferation (GO:0042100)3.33093664
54positive regulation of B cell proliferation (GO:0030890)3.31383931
55natural killer cell mediated immunity (GO:0002228)3.29903615
56natural killer cell mediated cytotoxicity (GO:0042267)3.29903615
57negative regulation of B cell proliferation (GO:0030889)3.29590791
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29085576
59response to host immune response (GO:0052572)3.29085576
60* cellular response to interferon-gamma (GO:0071346)3.28997652
61response to muramyl dipeptide (GO:0032495)3.27693894
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.26380480
63regulation of germinal center formation (GO:0002634)3.24664499
64regulation of gamma-delta T cell activation (GO:0046643)3.24488405
65CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.23042363
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22058441
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19652019
68B cell mediated immunity (GO:0019724)3.18370958
69positive regulation of B cell activation (GO:0050871)3.17002973
70positive regulation of defense response to virus by host (GO:0002230)3.14991795
71leukocyte mediated cytotoxicity (GO:0001909)3.14767231
72negative thymic T cell selection (GO:0045060)3.14689744
73* response to protozoan (GO:0001562)3.14331496
74dendritic cell differentiation (GO:0097028)3.13175868
75germinal center formation (GO:0002467)3.12817634
76negative regulation of myeloid cell apoptotic process (GO:0033033)3.12768550
77natural killer cell activation (GO:0030101)3.12585020
78response to peptidoglycan (GO:0032494)3.11996560
79T cell migration (GO:0072678)3.11409802
80mature B cell differentiation involved in immune response (GO:0002313)3.11113525
81detection of external biotic stimulus (GO:0098581)3.11043912
82T cell selection (GO:0045058)3.10663446
83dendritic cell chemotaxis (GO:0002407)3.10402745
84regulation of type 2 immune response (GO:0002828)3.10343579
85myeloid cell activation involved in immune response (GO:0002275)3.10138338
86positive regulation of isotype switching (GO:0045830)3.07970286
87mast cell activation (GO:0045576)3.06140120
88T cell costimulation (GO:0031295)3.04582391
89regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.04130223
90* positive regulation of interleukin-12 production (GO:0032735)3.04074620
91response to interleukin-15 (GO:0070672)3.03444282
92regulation of mast cell degranulation (GO:0043304)3.03260922
93positive thymic T cell selection (GO:0045059)3.02243821
94positive regulation of interferon-beta production (GO:0032728)3.01984485
95response to host (GO:0075136)3.01724756
96response to host defenses (GO:0052200)3.01724756
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01724756
98lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01613903
99thymic T cell selection (GO:0045061)3.00634120
100lymphocyte costimulation (GO:0031294)2.99998023
101positive regulation of mast cell activation (GO:0033005)2.99789242
102regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99489734
103* defense response to protozoan (GO:0042832)2.98957245
104response to interferon-beta (GO:0035456)2.97539832
105regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97271730
106JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96417337
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96119946
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.95587577
109positive T cell selection (GO:0043368)2.95439122
110negative T cell selection (GO:0043383)2.95325626
111* response to interferon-gamma (GO:0034341)2.92901656
112regulation of T-helper 2 cell differentiation (GO:0045628)2.92804251
113negative regulation of T cell mediated immunity (GO:0002710)2.92534795
114regulation of T-helper 1 cell differentiation (GO:0045625)2.91091333
115cellular response to interleukin-15 (GO:0071350)2.90314078
116leukocyte aggregation (GO:0070486)2.88266072
117cellular defense response (GO:0006968)2.86409748
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.86077574
119positive regulation of mast cell degranulation (GO:0043306)2.86077574
120positive regulation of immunoglobulin mediated immune response (GO:0002891)2.85989183
121positive regulation of B cell mediated immunity (GO:0002714)2.85989183
122microglial cell activation (GO:0001774)2.85965422
123mature B cell differentiation (GO:0002335)2.85332112
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84479293
125dendritic cell migration (GO:0036336)2.84240020
126positive regulation of natural killer cell differentiation (GO:0032825)2.84215723
127positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83833507
128regulation of interferon-beta production (GO:0032648)2.83633803
129negative regulation of granulocyte differentiation (GO:0030853)2.83038111
130regulation of response to interferon-gamma (GO:0060330)2.82934372
131cellular extravasation (GO:0045123)2.82829509
132myeloid leukocyte activation (GO:0002274)2.81850196
133adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.81783593
134B cell homeostasis (GO:0001782)2.81047595
135regulation of mast cell activation (GO:0033003)2.80399434
136natural killer cell differentiation (GO:0001779)2.78883564
137T cell proliferation (GO:0042098)2.78405687
138regulation of B cell proliferation (GO:0030888)2.78276663
139regulation of natural killer cell mediated immunity (GO:0002715)2.77728044
140regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77728044
141pinocytosis (GO:0006907)2.75853630
142negative regulation of cell killing (GO:0031342)2.75717796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.06371766
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.41826968
3E2F7_22180533_ChIP-Seq_HELA_Human5.22450660
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.46779033
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.17138668
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70249592
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.62227945
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56899392
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.46873842
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39954484
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.37222135
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18095750
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.06029254
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94537288
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93299189
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89502600
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75059635
18* VDR_21846776_ChIP-Seq_THP-1_Human2.56969069
19MYC_22102868_ChIP-Seq_BL_Human2.54410343
20MYB_26560356_Chip-Seq_TH2_Human2.44914221
21SPI1_23547873_ChIP-Seq_NB4_Human2.39015509
22MAF_26560356_Chip-Seq_TH1_Human2.28397478
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26668492
24SCL_19346495_ChIP-Seq_HPC-7_Human2.22176900
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17955944
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16315032
27* MYB_26560356_Chip-Seq_TH1_Human2.15609227
28* VDR_24763502_ChIP-Seq_THP-1_Human2.13214083
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10749564
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09112940
31RUNX_20019798_ChIP-Seq_JUKART_Human2.04094289
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03616219
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03548970
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00073722
35GATA1_22025678_ChIP-Seq_K562_Human1.95796109
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.87513225
37SPI1_23127762_ChIP-Seq_K562_Human1.78203552
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77877568
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72634562
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68579869
41* UTX_26944678_Chip-Seq_JUKART_Human1.67467810
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.65089648
43PU_27001747_Chip-Seq_BMDM_Mouse1.59260275
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56020092
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52299033
46TCF7_22412390_ChIP-Seq_EML_Mouse1.51591203
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51331732
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48125970
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46840839
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43357735
51GATA3_27048872_Chip-Seq_THYMUS_Human1.42681854
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37402053
53MAF_26560356_Chip-Seq_TH2_Human1.36976775
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36808061
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32029047
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31216396
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31144110
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30064786
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.25675543
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24103957
61LXR_22292898_ChIP-Seq_THP-1_Human1.23748605
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19800607
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19327730
64GATA3_26560356_Chip-Seq_TH2_Human1.16924325
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16094347
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14742052
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12692560
68CIITA_25753668_ChIP-Seq_RAJI_Human1.09956936
69VDR_24787735_ChIP-Seq_THP-1_Human1.09325920
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08330210
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06792492
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06345344
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06111069
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05632004
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04227092
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02885134
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02771748
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02073678
79* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01648153
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00754801
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00455153
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99901177
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99171375
84BCOR_27268052_Chip-Seq_Bcells_Human0.97896627
85KDM2B_26808549_Chip-Seq_DND41_Human0.97812594
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96263045
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94858625
88E2F1_21310950_ChIP-Seq_MCF-7_Human0.94672708
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.93829311
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.93382754
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92064932
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92042986
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.91636931
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90638751
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.90459331
96* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87616428
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87213420
98NCOR1_26117541_ChIP-Seq_K562_Human0.84572991
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81729648
100P300_27268052_Chip-Seq_Bcells_Human0.81398428
101VDR_23849224_ChIP-Seq_CD4+_Human0.80997320
102STAT1_20625510_ChIP-Seq_HELA_Human0.79885914
103TFEB_21752829_ChIP-Seq_HELA_Human0.75780388
104CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74773897
105GATA1_19941826_ChIP-Seq_K562_Human0.73119634
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72855343
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.71274476
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69382123
109FOXP3_21729870_ChIP-Seq_TREG_Human0.69314128
110SPI1_20517297_ChIP-Seq_HL60_Human0.68229966
111CTCF_26484167_Chip-Seq_Bcells_Mouse0.63294451
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.62208169
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62203916
114BCL6_27268052_Chip-Seq_Bcells_Human0.61582750
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61460686
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.61040329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.64297427
2MP0005671_abnormal_response_to3.86301631
3MP0000685_abnormal_immune_system3.45187413
4MP0001790_abnormal_immune_system3.39832949
5MP0005387_immune_system_phenotype3.39832949
6* MP0001800_abnormal_humoral_immune3.26702088
7MP0009785_altered_susceptibility_to3.15651941
8MP0005000_abnormal_immune_tolerance3.05477947
9MP0002148_abnormal_hypersensitivity_rea3.03755706
10MP0003436_decreased_susceptibility_to2.97702344
11MP0003303_peritoneal_inflammation2.94905895
12* MP0002452_abnormal_antigen_presenting2.92903234
13* MP0005025_abnormal_response_to2.80564688
14MP0006082_CNS_inflammation2.76743867
15* MP0002723_abnormal_immune_serum2.74966412
16MP0002419_abnormal_innate_immunity2.64731883
17* MP0001819_abnormal_immune_cell2.64401684
18* MP0002420_abnormal_adaptive_immunity2.63921940
19MP0002166_altered_tumor_susceptibility2.51705925
20MP0002396_abnormal_hematopoietic_system2.30913353
21* MP0002398_abnormal_bone_marrow2.26435779
22MP0004510_myositis2.18165022
23MP0003763_abnormal_thymus_physiology2.17233910
24* MP0000716_abnormal_immune_system2.16167107
25MP0001853_heart_inflammation2.15377632
26MP0002006_tumorigenesis2.15294007
27MP0002405_respiratory_system_inflammati2.06312766
28MP0001873_stomach_inflammation2.00219396
29MP0010155_abnormal_intestine_physiology1.91522380
30* MP0000689_abnormal_spleen_morphology1.88803395
31MP0005464_abnormal_platelet_physiology1.88081112
32MP0003300_gastrointestinal_ulcer1.87682282
33MP0009333_abnormal_splenocyte_physiolog1.83552320
34MP0001845_abnormal_inflammatory_respons1.83153407
35* MP0002429_abnormal_blood_cell1.78060880
36MP0005451_abnormal_body_composition1.76720258
37* MP0002722_abnormal_immune_system1.75386820
38MP0005310_abnormal_salivary_gland1.75155904
39MP0008057_abnormal_DNA_replication1.65574342
40MP0003724_increased_susceptibility_to1.52147493
41MP0010307_abnormal_tumor_latency1.50442264
42MP0003172_abnormal_lysosome_physiology1.48191876
43MP0003448_altered_tumor_morphology1.48062398
44MP0005058_abnormal_lysosome_morphology1.46700413
45MP0008469_abnormal_protein_level1.44396698
46MP0000703_abnormal_thymus_morphology1.42726572
47MP0004947_skin_inflammation1.38726535
48MP0003866_abnormal_defecation1.38504454
49MP0004808_abnormal_hematopoietic_stem1.37595332
50MP0000858_altered_metastatic_potential1.34529927
51MP0001533_abnormal_skeleton_physiology1.33055386
52MP0003183_abnormal_peptide_metabolism1.31722858
53MP0002138_abnormal_hepatobiliary_system1.26192744
54MP0005397_hematopoietic_system_phenotyp1.24395679
55MP0001545_abnormal_hematopoietic_system1.24395679
56MP0000490_abnormal_crypts_of1.19546924
57MP0005174_abnormal_tail_pigmentation1.17546078
58MP0003191_abnormal_cellular_cholesterol1.15495877
59MP0002139_abnormal_hepatobiliary_system1.11935296
60MP0002254_reproductive_system_inflammat1.11384127
61MP0009764_decreased_sensitivity_to1.08773287
62MP0000465_gastrointestinal_hemorrhage1.07754560
63MP0000343_altered_response_to1.06716995
64MP0009278_abnormal_bone_marrow0.98884433
65MP0008260_abnormal_autophagy0.96827689
66MP0000569_abnormal_digit_pigmentation0.96263618
67MP0009840_abnormal_foam_cell0.95906276
68MP0001348_abnormal_lacrimal_gland0.95092194
69MP0010352_gastrointestinal_tract_polyps0.94786988
70* MP0002019_abnormal_tumor_incidence0.93520040
71MP0000015_abnormal_ear_pigmentation0.92242302
72MP0003690_abnormal_glial_cell0.89506864
73MP0000371_diluted_coat_color0.85119802
74MP0002933_joint_inflammation0.84332488
75* MP0009763_increased_sensitivity_to0.82216407
76MP0010094_abnormal_chromosome_stability0.82166031
77MP0004883_abnormal_blood_vessel0.81761031
78MP0008004_abnormal_stomach_pH0.81503952
79MP0002998_abnormal_bone_remodeling0.81228610
80MP0003656_abnormal_erythrocyte_physiolo0.79917481
81MP0003693_abnormal_embryo_hatching0.78897701
82MP0000604_amyloidosis0.78100029
83MP0003077_abnormal_cell_cycle0.74673266
84MP0002009_preneoplasia0.73375981
85MP0001663_abnormal_digestive_system0.73243520
86MP0001851_eye_inflammation0.72971822
87MP0000249_abnormal_blood_vessel0.72720788
88MP0003075_altered_response_to0.71763556
89MP0003828_pulmonary_edema0.71355704
90MP0005076_abnormal_cell_differentiation0.70025742
91MP0005075_abnormal_melanosome_morpholog0.69791599
92MP0004782_abnormal_surfactant_physiolog0.69641455
93MP0005166_decreased_susceptibility_to0.68106690
94MP0002095_abnormal_skin_pigmentation0.63552882
95MP0002928_abnormal_bile_duct0.61820776
96MP0003453_abnormal_keratinocyte_physiol0.60491308
97MP0002136_abnormal_kidney_physiology0.59161939
98MP0005164_abnormal_response_to0.58539981
99MP0002332_abnormal_exercise_endurance0.57250089
100MP0008874_decreased_physiological_sensi0.56978473
101MP0006054_spinal_hemorrhage0.54799927
102MP0008873_increased_physiological_sensi0.54763893
103MP0008007_abnormal_cellular_replicative0.54685531
104MP0002876_abnormal_thyroid_physiology0.54447212
105MP0009765_abnormal_xenobiotic_induced0.54177270
106MP0002693_abnormal_pancreas_physiology0.53847005
107MP0000313_abnormal_cell_death0.53428899
108MP0003795_abnormal_bone_structure0.53390534
109MP0003806_abnormal_nucleotide_metabolis0.51632070
110MP0003091_abnormal_cell_migration0.51363958
111MP0008058_abnormal_DNA_repair0.51243388
112MP0002132_abnormal_respiratory_system0.50022829
113MP0005390_skeleton_phenotype0.49760350
114MP0000609_abnormal_liver_physiology0.49263448
115MP0002163_abnormal_gland_morphology0.48622078
116MP0005535_abnormal_body_temperature0.47749277
117MP0005381_digestive/alimentary_phenotyp0.47510170
118MP0003045_fibrosis0.47148552
119MP0002277_abnormal_respiratory_mucosa0.46449425

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.47920841
2Recurrent bacterial skin infections (HP:0005406)5.33674294
3Eczematoid dermatitis (HP:0000976)5.06443005
4Elevated erythrocyte sedimentation rate (HP:0003565)4.85299608
5Recurrent viral infections (HP:0004429)4.69433574
6Chronic otitis media (HP:0000389)4.60349926
7Agammaglobulinemia (HP:0004432)4.38355153
8Recurrent fungal infections (HP:0002841)4.36405388
9Myositis (HP:0100614)4.20659208
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.20372306
11Meningitis (HP:0001287)4.05522425
12Recurrent cutaneous fungal infections (HP:0011370)3.95890007
13Chronic mucocutaneous candidiasis (HP:0002728)3.95890007
14Recurrent skin infections (HP:0001581)3.95877290
15Colitis (HP:0002583)3.92633210
16Thrombocytosis (HP:0001894)3.88304818
17Abnormality of macrophages (HP:0004311)3.85661551
18Recurrent bronchitis (HP:0002837)3.84193985
19Mediastinal lymphadenopathy (HP:0100721)3.81226956
20Cellulitis (HP:0100658)3.78101008
21IgM deficiency (HP:0002850)3.75842908
22Panhypogammaglobulinemia (HP:0003139)3.72787583
23Vasculitis (HP:0002633)3.68324822
24Inflammation of the large intestine (HP:0002037)3.67387454
25Gastrointestinal inflammation (HP:0004386)3.54824613
26Nasal polyposis (HP:0100582)3.50784240
27Recurrent gram-negative bacterial infections (HP:0005420)3.45523517
28Abnormality of T cell physiology (HP:0011840)3.38570230
29Obstructive lung disease (HP:0006536)3.30048434
30Chronic obstructive pulmonary disease (HP:0006510)3.30048434
31Spontaneous hematomas (HP:0007420)3.24034752
32Autoimmune thrombocytopenia (HP:0001973)3.20139665
33Abnormality of liposaccharide metabolism (HP:0010968)3.15314367
34Encephalitis (HP:0002383)3.03442214
35Gastrointestinal stroma tumor (HP:0100723)3.03355043
36Abnormality of the nasal mucosa (HP:0000433)3.00207348
37Abnormality of T cells (HP:0002843)2.97195131
38Urticaria (HP:0001025)2.92876929
39Interstitial pulmonary disease (HP:0006530)2.89288101
40Basal ganglia calcification (HP:0002135)2.86134722
41Orchitis (HP:0100796)2.83700301
42Recurrent pneumonia (HP:0006532)2.82935022
43Recurrent lower respiratory tract infections (HP:0002783)2.81170151
44Chronic sinusitis (HP:0011109)2.79503982
45Eosinophilia (HP:0001880)2.78973501
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.77338216
47Lymphopenia (HP:0001888)2.77102219
48Periodontitis (HP:0000704)2.76554603
49Optic neuritis (HP:0100653)2.76550823
50Retrobulbar optic neuritis (HP:0100654)2.76550823
51Restrictive lung disease (HP:0002091)2.76446281
52Pulmonary infiltrates (HP:0002113)2.75263553
53Osteomyelitis (HP:0002754)2.74401438
54Systemic lupus erythematosus (HP:0002725)2.68712451
55Recurrent sinusitis (HP:0011108)2.68168395
56IgA deficiency (HP:0002720)2.68152598
57Gingivitis (HP:0000230)2.67795064
58Hypergammaglobulinemia (HP:0010702)2.66511785
59Increased cerebral lipofuscin (HP:0011813)2.66477309
60Skin rash (HP:0000988)2.62782163
61Autoimmune hemolytic anemia (HP:0001890)2.62015298
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.61099830
63Chronic diarrhea (HP:0002028)2.57759145
64IgG deficiency (HP:0004315)2.55350177
65Emphysema (HP:0002097)2.55177005
66Granulocytopenia (HP:0001913)2.55161791
67Increased IgE level (HP:0003212)2.54319301
68Pustule (HP:0200039)2.53511177
69Abnormality of the pleura (HP:0002103)2.52973793
70Abnormality of the fingertips (HP:0001211)2.45923127
71Dysostosis multiplex (HP:0000943)2.44622248
72B lymphocytopenia (HP:0010976)2.41998062
73Abnormality of B cell number (HP:0010975)2.41998062
74Abnormality of T cell number (HP:0011839)2.41782810
75Spinal cord lesions (HP:0100561)2.38482790
76Syringomyelia (HP:0003396)2.38482790
77Lymphoma (HP:0002665)2.37740504
78Absent frontal sinuses (HP:0002688)2.37697180
79Thyroiditis (HP:0100646)2.36995296
80Chest pain (HP:0100749)2.36846040
81Gastrointestinal infarctions (HP:0005244)2.35340527
82Increased IgM level (HP:0003496)2.33750974
83Leukopenia (HP:0001882)2.33550799
84Hemoptysis (HP:0002105)2.33382828
85Verrucae (HP:0200043)2.32318618
86Papilloma (HP:0012740)2.32318618
87Gangrene (HP:0100758)2.31655952
88Amyloidosis (HP:0011034)2.31026343
89Skin ulcer (HP:0200042)2.30339474
90Petechiae (HP:0000967)2.29362782
91Arterial thrombosis (HP:0004420)2.29312838
92Leukocytosis (HP:0001974)2.27293607
93Agnosia (HP:0010524)2.26668728
94Keratoconjunctivitis (HP:0001096)2.25527292
95Vacuolated lymphocytes (HP:0001922)2.24297965
96T lymphocytopenia (HP:0005403)2.24060009
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23989966
98Sepsis (HP:0100806)2.21586794
99Stomatitis (HP:0010280)2.20659635
100Hematochezia (HP:0002573)2.17690518
101Papilledema (HP:0001085)2.16444445
102Abnormality of eosinophils (HP:0001879)2.15861555
103Viral hepatitis (HP:0006562)2.15501406
104Keratoconjunctivitis sicca (HP:0001097)2.14677515
105Loss of speech (HP:0002371)2.13962562
106Arthralgia (HP:0002829)2.13381784
107Hypertensive crisis (HP:0100735)2.13177569
108Disinhibition (HP:0000734)2.11419445
109Fatigue (HP:0012378)2.08731887
110Abnormality of the prostate (HP:0008775)2.08712333
111Pulmonary embolism (HP:0002204)2.08574628
112Abnormality of glycosphingolipid metabolism (HP:0004343)2.06842388
113Abnormality of glycolipid metabolism (HP:0010969)2.06842388
114Epistaxis (HP:0000421)2.04792963
115Combined immunodeficiency (HP:0005387)2.04359779
116Polyneuropathy (HP:0001271)2.03382601
117Purpura (HP:0000979)2.00504394
118Severe combined immunodeficiency (HP:0004430)1.98059426
119Abnormality of the peritoneum (HP:0002585)1.97812647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.90848935
2MAP3K143.88413486
3TYK23.42839535
4BLK3.38375338
5IRAK42.90591241
6TBK12.82105086
7PRPF4B2.75429517
8JAK32.70194979
9KIT2.68833836
10CSF1R2.44080542
11JAK12.37855850
12IKBKB2.19144408
13TXK2.18591311
14IKBKE2.12122727
15SYK2.08111900
16ZAP702.03071471
17IRAK32.00995535
18BTK1.96350229
19RIPK41.92801713
20MAP3K131.91326913
21CLK11.77248729
22ERN11.76043297
23TEC1.68230005
24TAOK31.59535522
25CSK1.55714734
26CHUK1.51020250
27PIM21.50723384
28STK101.50602136
29FES1.50328472
30EPHB11.50046682
31MAP3K101.48707452
32GRK61.44375936
33ITK1.35493380
34LYN1.31138288
35PIM11.29822605
36LCK1.28793750
37HCK1.26100492
38EEF2K1.23361943
39RPS6KA41.21458899
40FGR1.19882564
41FLT31.16140702
42FGFR41.12493832
43MAP2K31.11559357
44TGFBR21.11457390
45LRRK21.10100523
46TAOK21.08785225
47CDC42BPA0.99469567
48FGFR30.94878075
49MOS0.93310297
50JAK20.89973574
51GRK70.88915918
52SMG10.87561895
53MST40.86575049
54MAPK120.85127522
55SIK30.81922369
56NEK90.80482034
57STK40.80050346
58MAPK70.78333688
59MATK0.78193400
60TAOK10.77556014
61MAP3K10.75347341
62SIK20.73169474
63NLK0.72459091
64MAP3K80.70980855
65CDK120.69115440
66TRPM70.68422183
67PRKCQ0.67243134
68IRAK20.66560127
69CDK40.65713662
70EIF2AK30.64695132
71MAP3K30.63590442
72EPHA30.60561751
73MARK30.60310079
74CDK190.60193339
75ARAF0.58635588
76SCYL20.55150316
77TRIB30.54901121
78ATR0.54498857
79NME20.53963814
80ADRBK20.52187259
81RPS6KA60.50892151
82ABL10.49660257
83PDPK10.49053730
84KDR0.43407692
85MAPKAPK20.43382783
86BMPR20.43292520
87NEK20.42760045
88PRKCD0.41668232
89EIF2AK10.40452693
90EGFR0.40211774
91EIF2AK20.39525706
92MAP3K50.39010164
93CDK60.38932894
94MAPK40.38156050
95PTK60.38139790
96RPS6KC10.37778567
97RPS6KL10.37778567
98MAPK110.37567316
99HIPK20.33907963
100PDK10.33421377
101PASK0.32865128
102FYN0.32797107
103NUAK10.31792820
104DDR20.30866272
105PAK40.30499266
106IRAK10.28192678
107MARK20.28041320
108MAP3K110.27480740
109SIK10.26215815
110KSR20.24899801
111ALK0.24508600
112RIPK10.24431894
113TNK20.23723129
114TSSK60.23398472
115RPS6KA50.23080804
116VRK10.23064827
117MAP2K20.22538727
118YES10.21710062
119PIK3CG0.21153486
120PKN20.20592940
121INSR0.19606536
122RAF10.18359993
123MAPK30.17536243
124TESK20.17079980
125MAP2K60.16932003

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.54799927
2Graft-versus-host disease_Homo sapiens_hsa053323.34648269
3Primary immunodeficiency_Homo sapiens_hsa053403.19507022
4Leishmaniasis_Homo sapiens_hsa051402.80701264
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.65887900
6B cell receptor signaling pathway_Homo sapiens_hsa046622.62652140
7Antigen processing and presentation_Homo sapiens_hsa046122.57192019
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.51125700
9Measles_Homo sapiens_hsa051622.38551607
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31976196
11Osteoclast differentiation_Homo sapiens_hsa043802.29681551
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21789077
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17571341
14Type I diabetes mellitus_Homo sapiens_hsa049402.12976163
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09411437
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02027256
17Autoimmune thyroid disease_Homo sapiens_hsa053201.97135789
18Herpes simplex infection_Homo sapiens_hsa051681.89849668
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79148685
20Influenza A_Homo sapiens_hsa051641.78817811
21Toxoplasmosis_Homo sapiens_hsa051451.71612327
22Viral myocarditis_Homo sapiens_hsa054161.67831309
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.62992965
24Tuberculosis_Homo sapiens_hsa051521.62070642
25DNA replication_Homo sapiens_hsa030301.61521640
26Staphylococcus aureus infection_Homo sapiens_hsa051501.54616943
27* Pertussis_Homo sapiens_hsa051331.53642599
28Legionellosis_Homo sapiens_hsa051341.53247082
29Apoptosis_Homo sapiens_hsa042101.51648461
30Chemokine signaling pathway_Homo sapiens_hsa040621.48660302
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41492136
32Hematopoietic cell lineage_Homo sapiens_hsa046401.40434474
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.39083047
34TNF signaling pathway_Homo sapiens_hsa046681.37480149
35Shigellosis_Homo sapiens_hsa051311.35029769
36Malaria_Homo sapiens_hsa051441.34298690
37T cell receptor signaling pathway_Homo sapiens_hsa046601.33222588
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29825836
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29221594
40Hepatitis B_Homo sapiens_hsa051611.28596214
41Asthma_Homo sapiens_hsa053101.25378100
42Base excision repair_Homo sapiens_hsa034101.24653173
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22080570
44Other glycan degradation_Homo sapiens_hsa005111.16731549
45Mismatch repair_Homo sapiens_hsa034301.10955082
46Acute myeloid leukemia_Homo sapiens_hsa052211.09451416
47African trypanosomiasis_Homo sapiens_hsa051431.05360561
48Salmonella infection_Homo sapiens_hsa051321.04533768
49Epstein-Barr virus infection_Homo sapiens_hsa051690.98839486
50Lysosome_Homo sapiens_hsa041420.96972490
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.94997626
52Chronic myeloid leukemia_Homo sapiens_hsa052200.94536488
53Hepatitis C_Homo sapiens_hsa051600.91958364
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88267424
55Non-homologous end-joining_Homo sapiens_hsa034500.87627442
56Pancreatic cancer_Homo sapiens_hsa052120.83089451
57Viral carcinogenesis_Homo sapiens_hsa052030.77087674
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76936893
59Homologous recombination_Homo sapiens_hsa034400.74813893
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74670378
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73862355
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72179236
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69702145
64Rheumatoid arthritis_Homo sapiens_hsa053230.69186792
65HTLV-I infection_Homo sapiens_hsa051660.68607149
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67268619
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.67036376
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65710451
69Platelet activation_Homo sapiens_hsa046110.64819344
70Small cell lung cancer_Homo sapiens_hsa052220.63966794
71Prolactin signaling pathway_Homo sapiens_hsa049170.59817248
72p53 signaling pathway_Homo sapiens_hsa041150.58230418
73Phagosome_Homo sapiens_hsa041450.55883626
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54940971
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51414418
76Ribosome_Homo sapiens_hsa030100.42712419
77Non-small cell lung cancer_Homo sapiens_hsa052230.39025612
78One carbon pool by folate_Homo sapiens_hsa006700.36653708
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35637026
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34739489
81Systemic lupus erythematosus_Homo sapiens_hsa053220.33413491
82MicroRNAs in cancer_Homo sapiens_hsa052060.33078386
83HIF-1 signaling pathway_Homo sapiens_hsa040660.31432210
84VEGF signaling pathway_Homo sapiens_hsa043700.31357779
85Fanconi anemia pathway_Homo sapiens_hsa034600.29610831
86Spliceosome_Homo sapiens_hsa030400.29582597
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29475783
88ABC transporters_Homo sapiens_hsa020100.29365659
89Amoebiasis_Homo sapiens_hsa051460.28186539
90Notch signaling pathway_Homo sapiens_hsa043300.27302454
91Colorectal cancer_Homo sapiens_hsa052100.26261329
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.25294686
93Pentose phosphate pathway_Homo sapiens_hsa000300.25154821
94Nucleotide excision repair_Homo sapiens_hsa034200.24456493
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23713361
96Cell cycle_Homo sapiens_hsa041100.23279394
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.20815285
98Endocytosis_Homo sapiens_hsa041440.20571187
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19547528
100Renal cell carcinoma_Homo sapiens_hsa052110.19345230
101Renin-angiotensin system_Homo sapiens_hsa046140.18808703
102Proteasome_Homo sapiens_hsa030500.18626392
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18441531
104Bladder cancer_Homo sapiens_hsa052190.17004550
105Insulin resistance_Homo sapiens_hsa049310.16300066
106MAPK signaling pathway_Homo sapiens_hsa040100.16220734
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.15333916
108Type II diabetes mellitus_Homo sapiens_hsa049300.15078965
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14102183
110Ether lipid metabolism_Homo sapiens_hsa005650.09912673
111FoxO signaling pathway_Homo sapiens_hsa040680.09089535
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.08999437
113Prostate cancer_Homo sapiens_hsa052150.08775723
114mTOR signaling pathway_Homo sapiens_hsa041500.07166414
115GnRH signaling pathway_Homo sapiens_hsa049120.06323812
116Dorso-ventral axis formation_Homo sapiens_hsa043200.05117454
117Prion diseases_Homo sapiens_hsa050200.04569490
118Sphingolipid metabolism_Homo sapiens_hsa006000.03348694
119Inositol phosphate metabolism_Homo sapiens_hsa005620.02606637

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »