IRF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.07385348
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.07385348
3antigen processing and presentation of endogenous antigen (GO:0019883)6.47907170
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.75519464
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.72760718
6negative regulation of cell killing (GO:0031342)5.72760718
7positive regulation of gamma-delta T cell activation (GO:0046645)5.00744746
8* response to type I interferon (GO:0034340)4.70469219
9* cellular response to type I interferon (GO:0071357)4.66442137
10* type I interferon signaling pathway (GO:0060337)4.66442137
11response to interferon-alpha (GO:0035455)4.13574470
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.04380274
13response to interferon-beta (GO:0035456)4.02870738
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99912772
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.93887324
16negative regulation of interleukin-12 production (GO:0032695)3.91552876
17positive regulation of interferon-alpha production (GO:0032727)3.86054101
18regulation of gamma-delta T cell differentiation (GO:0045586)3.83757444
19negative regulation of lymphocyte mediated immunity (GO:0002707)3.77406328
20regulation of B cell receptor signaling pathway (GO:0050855)3.74975213
21antigen processing and presentation via MHC class Ib (GO:0002475)3.72473710
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70005752
23detection of external biotic stimulus (GO:0098581)3.69234592
24regulation of interferon-alpha production (GO:0032647)3.66292093
25regulation of gamma-delta T cell activation (GO:0046643)3.63392022
26cellular response to interferon-beta (GO:0035458)3.58402959
27immunoglobulin mediated immune response (GO:0016064)3.58321577
28* interferon-gamma-mediated signaling pathway (GO:0060333)3.52881584
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.52810887
30negative regulation of leukocyte mediated immunity (GO:0002704)3.52683504
31positive regulation of B cell differentiation (GO:0045579)3.45710606
32regulation of RIG-I signaling pathway (GO:0039535)3.41048439
33regulation of tolerance induction (GO:0002643)3.39418435
34positive regulation of antigen processing and presentation (GO:0002579)3.37990996
35positive regulation of natural killer cell differentiation (GO:0032825)3.34355172
36regulation of type I interferon-mediated signaling pathway (GO:0060338)3.34076765
37germinal center formation (GO:0002467)3.31821885
38tolerance induction (GO:0002507)3.31536792
39regulation of B cell differentiation (GO:0045577)3.31478591
40regulation of interferon-beta biosynthetic process (GO:0045357)3.31302771
41negative regulation of T cell mediated immunity (GO:0002710)3.29920466
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25703469
43detection of biotic stimulus (GO:0009595)3.23071743
44defense response to protozoan (GO:0042832)3.22098658
45detection of molecule of bacterial origin (GO:0032490)3.21150366
46T cell migration (GO:0072678)3.20280702
47NIK/NF-kappaB signaling (GO:0038061)3.19277458
48neutrophil activation (GO:0042119)3.19193930
49response to host immune response (GO:0052572)3.17334407
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17334407
51cellular extravasation (GO:0045123)3.11558268
52regulation of response to interferon-gamma (GO:0060330)3.10291618
53negative regulation of innate immune response (GO:0045824)3.09437805
54ribosomal small subunit assembly (GO:0000028)3.09289110
55positive regulation of tolerance induction (GO:0002645)3.07764613
56response to protozoan (GO:0001562)3.07570992
57leukocyte aggregation (GO:0070486)3.06822464
58myeloid dendritic cell activation (GO:0001773)3.03386304
59granulocyte activation (GO:0036230)3.02803840
60negative regulation of cytokine production involved in immune response (GO:0002719)3.01646172
61microglial cell activation (GO:0001774)3.00428215
62regulation of natural killer cell differentiation (GO:0032823)2.99177025
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99117167
64regulation of antigen processing and presentation (GO:0002577)2.99094467
65myeloid cell activation involved in immune response (GO:0002275)2.98218503
66response to muramyl dipeptide (GO:0032495)2.97965576
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95696225
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94341119
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92752083
70response to host (GO:0075136)2.92752083
71response to host defenses (GO:0052200)2.92752083
72negative regulation of viral genome replication (GO:0045071)2.91821329
73positive regulation of type 2 immune response (GO:0002830)2.91501988
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91456730
75regulation of alpha-beta T cell proliferation (GO:0046640)2.90212724
76regulation of natural killer cell mediated immunity (GO:0002715)2.90051556
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90051556
78positive regulation of interferon-beta production (GO:0032728)2.89800798
79respiratory burst (GO:0045730)2.89761852
80regulation of T cell receptor signaling pathway (GO:0050856)2.88614589
81negative thymic T cell selection (GO:0045060)2.88195633
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.87829060
83response to interleukin-15 (GO:0070672)2.86298938
84B cell mediated immunity (GO:0019724)2.85870292
85negative T cell selection (GO:0043383)2.85824557
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.85517819
87macrophage activation (GO:0042116)2.84905487
88positive regulation by symbiont of host defense response (GO:0052509)2.82724408
89modulation by symbiont of host defense response (GO:0052031)2.82724408
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82724408
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82724408
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.82724408
93modulation by symbiont of host immune response (GO:0052553)2.82724408
94positive thymic T cell selection (GO:0045059)2.80765478
95B cell receptor signaling pathway (GO:0050853)2.79770166
96regulation of T-helper 1 cell differentiation (GO:0045625)2.78218274
97cellular response to exogenous dsRNA (GO:0071360)2.77202799
98regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.76509486
99detection of other organism (GO:0098543)2.76457957
100thymic T cell selection (GO:0045061)2.76313096
101T cell selection (GO:0045058)2.76012783
102myeloid dendritic cell differentiation (GO:0043011)2.75149225
103regulation of type 2 immune response (GO:0002828)2.73648784
104negative regulation of type 2 immune response (GO:0002829)2.72389792
105negative regulation of B cell apoptotic process (GO:0002903)2.70731792
106mature B cell differentiation (GO:0002335)2.70642283
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69943593
108neutrophil activation involved in immune response (GO:0002283)2.69527214
109negative regulation of erythrocyte differentiation (GO:0045647)2.69089401
110positive regulation of humoral immune response (GO:0002922)2.68653632
111interferon-gamma production (GO:0032609)2.67407890
112regulation of regulatory T cell differentiation (GO:0045589)2.66355548
113positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65939654
114detection of bacterium (GO:0016045)2.62277804
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61794305
116DNA deamination (GO:0045006)2.61074444
117regulation of T cell tolerance induction (GO:0002664)2.59672308
118mature B cell differentiation involved in immune response (GO:0002313)2.56381210
119response to peptidoglycan (GO:0032494)2.55357362
120cellular response to interleukin-15 (GO:0071350)2.54970196
121* cellular response to interferon-gamma (GO:0071346)2.53953500
122positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51930114
123macrophage activation involved in immune response (GO:0002281)2.51746792
124positive regulation of isotype switching (GO:0045830)2.51606399
125* defense response to virus (GO:0051607)2.51536666
126positive regulation of macrophage differentiation (GO:0045651)2.51250593
127dendritic cell chemotaxis (GO:0002407)2.51033392
128negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.50256346
129cellular response to zinc ion (GO:0071294)2.50191964
130T cell homeostasis (GO:0043029)2.49649980
131regulation of T cell mediated cytotoxicity (GO:0001914)2.48097772
132dendritic cell migration (GO:0036336)2.47831189
133positive regulation of immunoglobulin mediated immune response (GO:0002891)2.46909046
134positive regulation of B cell mediated immunity (GO:0002714)2.46909046
135cellular response to virus (GO:0098586)2.44387350
136regulation of B cell apoptotic process (GO:0002902)2.43368442
137mast cell activation (GO:0045576)2.43079386
138T-helper 1 type immune response (GO:0042088)2.42555291
139necroptotic process (GO:0070266)2.42368324
140* response to interferon-gamma (GO:0034341)2.41724839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.65078811
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.66213891
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53771968
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.49510159
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36952767
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77327867
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.34649165
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16659123
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.99810275
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85366469
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80280963
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68765920
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67122742
14SCL_19346495_ChIP-Seq_HPC-7_Human2.64040568
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59942630
16GATA1_22025678_ChIP-Seq_K562_Human2.54395576
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39771855
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35888568
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30046115
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24801196
21MYB_26560356_Chip-Seq_TH2_Human2.18210363
22SPI1_23547873_ChIP-Seq_NB4_Human2.17426293
23RUNX_20019798_ChIP-Seq_JUKART_Human2.14102565
24* MAF_26560356_Chip-Seq_TH1_Human2.08838521
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07413316
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07384965
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05765542
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03901092
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99602883
30MYB_26560356_Chip-Seq_TH1_Human1.96883414
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.93080607
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86582887
33VDR_21846776_ChIP-Seq_THP-1_Human1.83157739
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.81588703
35VDR_24763502_ChIP-Seq_THP-1_Human1.77680998
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77016048
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.76497822
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75894393
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.71943027
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.71490638
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69599061
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67910308
43MYC_22102868_ChIP-Seq_BL_Human1.67843630
44UTX_26944678_Chip-Seq_JUKART_Human1.66862569
45* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60940823
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60215466
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59464635
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58873004
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55748144
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55647580
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49700690
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49014131
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48086628
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47667183
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45806916
56LXR_22292898_ChIP-Seq_THP-1_Human1.42708868
57E2F7_22180533_ChIP-Seq_HELA_Human1.40488943
58KDM2B_26808549_Chip-Seq_DND41_Human1.37045020
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36598952
60PU_27001747_Chip-Seq_BMDM_Mouse1.33462261
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31826020
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30866710
63GATA3_27048872_Chip-Seq_THYMUS_Human1.30036893
64MAF_26560356_Chip-Seq_TH2_Human1.28639368
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28554632
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28317034
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27273164
68* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27150154
69SPI1_23127762_ChIP-Seq_K562_Human1.26971268
70BCL6_27268052_Chip-Seq_Bcells_Human1.26964732
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.26102680
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.24268226
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23755761
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23179738
75TCF7_22412390_ChIP-Seq_EML_Mouse1.22426569
76GATA3_26560356_Chip-Seq_TH2_Human1.17844728
77BCOR_27268052_Chip-Seq_Bcells_Human1.16430067
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.14348149
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11336382
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11126211
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09700061
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08783817
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07439393
84* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06788631
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05736530
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05496166
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05076858
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.04729264
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03132484
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02158779
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01747186
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99213423
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98979466
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98510033
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98049752
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97699848
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97655956
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.92055542
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91341427
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91097931
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90815531
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90699440
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89420100
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88777881
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.87012853
106STAT1_20625510_ChIP-Seq_HELA_Human0.86237573
107VDR_24787735_ChIP-Seq_THP-1_Human0.83680770
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83661261
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82480668
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82391710
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82227922
112RACK7_27058665_Chip-Seq_MCF-7_Human0.81971688
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80260308
114P300_27268052_Chip-Seq_Bcells_Human0.79700529
115GATA2_19941826_ChIP-Seq_K562_Human0.79584548
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.78725012
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78173262
118GATA1_19941826_ChIP-Seq_K562_Human0.76625768
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74063483
120* VDR_23849224_ChIP-Seq_CD4+_Human0.68837022
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67971811
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67868651
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67263709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23921090
2MP0009785_altered_susceptibility_to3.38340841
3MP0000685_abnormal_immune_system3.29679705
4MP0003724_increased_susceptibility_to3.13538086
5MP0005671_abnormal_response_to3.05578044
6MP0003436_decreased_susceptibility_to2.84363567
7MP0001790_abnormal_immune_system2.81803323
8MP0005387_immune_system_phenotype2.81803323
9MP0001800_abnormal_humoral_immune2.70495146
10* MP0005025_abnormal_response_to2.68223395
11MP0003763_abnormal_thymus_physiology2.61859788
12MP0002148_abnormal_hypersensitivity_rea2.58495938
13MP0005000_abnormal_immune_tolerance2.56187727
14MP0002452_abnormal_antigen_presenting2.47221905
15* MP0002723_abnormal_immune_serum2.41771846
16MP0002419_abnormal_innate_immunity2.29829964
17MP0002420_abnormal_adaptive_immunity2.25498355
18MP0001819_abnormal_immune_cell2.25165345
19MP0002396_abnormal_hematopoietic_system2.22848702
20MP0002166_altered_tumor_susceptibility2.22739658
21MP0005464_abnormal_platelet_physiology2.18511449
22MP0006082_CNS_inflammation2.03132754
23MP0001853_heart_inflammation1.98185631
24MP0002398_abnormal_bone_marrow1.97930057
25MP0003303_peritoneal_inflammation1.97414856
26MP0010155_abnormal_intestine_physiology1.92912132
27MP0000716_abnormal_immune_system1.88472696
28MP0002405_respiratory_system_inflammati1.85012956
29MP0003191_abnormal_cellular_cholesterol1.81738890
30MP0002006_tumorigenesis1.81580180
31MP0004947_skin_inflammation1.77486763
32MP0001873_stomach_inflammation1.76546594
33MP0001545_abnormal_hematopoietic_system1.76063775
34MP0005397_hematopoietic_system_phenotyp1.76063775
35MP0000689_abnormal_spleen_morphology1.73668628
36MP0001845_abnormal_inflammatory_respons1.73217721
37MP0009333_abnormal_splenocyte_physiolog1.65852051
38MP0002722_abnormal_immune_system1.64300774
39MP0008469_abnormal_protein_level1.63473795
40MP0002429_abnormal_blood_cell1.61337193
41MP0003300_gastrointestinal_ulcer1.58040358
42MP0002254_reproductive_system_inflammat1.54547122
43MP0003172_abnormal_lysosome_physiology1.52496369
44MP0009764_decreased_sensitivity_to1.52452442
45MP0004808_abnormal_hematopoietic_stem1.48078999
46MP0003183_abnormal_peptide_metabolism1.44984718
47MP0009278_abnormal_bone_marrow1.44272176
48MP0001533_abnormal_skeleton_physiology1.43828859
49MP0000465_gastrointestinal_hemorrhage1.36487950
50MP0005058_abnormal_lysosome_morphology1.35107335
51MP0002138_abnormal_hepatobiliary_system1.32200971
52MP0008260_abnormal_autophagy1.31471303
53MP0003866_abnormal_defecation1.28882310
54MP0005451_abnormal_body_composition1.27101457
55MP0000703_abnormal_thymus_morphology1.24586334
56MP0005365_abnormal_bile_salt1.22508311
57MP0002933_joint_inflammation1.21803103
58MP0000858_altered_metastatic_potential1.19711981
59MP0004510_myositis1.17231418
60MP0005360_urolithiasis1.16218218
61MP0009840_abnormal_foam_cell1.14755883
62MP0000490_abnormal_crypts_of1.14432205
63MP0002139_abnormal_hepatobiliary_system1.12178118
64MP0004883_abnormal_blood_vessel1.09466667
65MP0005075_abnormal_melanosome_morpholog1.08322985
66MP0005174_abnormal_tail_pigmentation1.06908922
67MP0006054_spinal_hemorrhage1.06801238
68MP0000343_altered_response_to1.06323193
69MP0009763_increased_sensitivity_to1.06304960
70MP0000604_amyloidosis1.06060365
71MP0008007_abnormal_cellular_replicative1.05235759
72MP0003045_fibrosis1.03053960
73MP0003448_altered_tumor_morphology1.02942716
74MP0003690_abnormal_glial_cell0.99249294
75MP0005085_abnormal_gallbladder_physiolo0.98002157
76MP0000609_abnormal_liver_physiology0.97678754
77MP0005164_abnormal_response_to0.97191066
78MP0005310_abnormal_salivary_gland0.96824526
79MP0002132_abnormal_respiratory_system0.95238765
80MP0003656_abnormal_erythrocyte_physiolo0.93416473
81MP0003186_abnormal_redox_activity0.88071984
82MP0008875_abnormal_xenobiotic_pharmacok0.87004375
83MP0005023_abnormal_wound_healing0.84686727
84MP0004381_abnormal_hair_follicle0.83507579
85MP0005167_abnormal_blood-brain_barrier0.81525272
86MP0002019_abnormal_tumor_incidence0.81315830
87MP0008004_abnormal_stomach_pH0.79545701
88MP0003806_abnormal_nucleotide_metabolis0.78033238
89MP0001851_eye_inflammation0.77707281
90MP0009765_abnormal_xenobiotic_induced0.77236526
91MP0002095_abnormal_skin_pigmentation0.76982350
92MP0002136_abnormal_kidney_physiology0.76491588
93MP0002998_abnormal_bone_remodeling0.75969952
94MP0003075_altered_response_to0.75694023
95MP0003943_abnormal_hepatobiliary_system0.75598269
96MP0003828_pulmonary_edema0.75161161
97MP0000598_abnormal_liver_morphology0.73999389
98MP0002277_abnormal_respiratory_mucosa0.72972776
99MP0009379_abnormal_foot_pigmentation0.72586535
100MP0000249_abnormal_blood_vessel0.72331900
101MP0003252_abnormal_bile_duct0.70886686
102MP0008874_decreased_physiological_sensi0.70502828
103MP0010329_abnormal_lipoprotein_level0.69696114
104MP0004782_abnormal_surfactant_physiolog0.68588111
105MP0003195_calcinosis0.67940598
106MP0005319_abnormal_enzyme/_coenzyme0.67926970
107MP0005166_decreased_susceptibility_to0.67090512
108MP0009643_abnormal_urine_homeostasis0.66951686
109MP0003566_abnormal_cell_adhesion0.66543602
110MP0005390_skeleton_phenotype0.66151044
111MP0001879_abnormal_lymphatic_vessel0.65632957
112MP0001663_abnormal_digestive_system0.63747003
113MP0001764_abnormal_homeostasis0.63012366
114* MP0003795_abnormal_bone_structure0.62134832
115MP0003453_abnormal_keratinocyte_physiol0.61091521
116MP0003091_abnormal_cell_migration0.59332129
117MP0001542_abnormal_bone_strength0.59267500
118MP0005381_digestive/alimentary_phenotyp0.59235326
119MP0002332_abnormal_exercise_endurance0.56875370
120MP0002693_abnormal_pancreas_physiology0.55300138
121MP0005165_increased_susceptibility_to0.55099590
122MP0001958_emphysema0.54586102
123MP0003329_amyloid_beta_deposits0.52573511

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.77964661
2Eczematoid dermatitis (HP:0000976)4.47551112
3Chronic otitis media (HP:0000389)4.44693855
4Myositis (HP:0100614)4.19712907
5Recurrent abscess formation (HP:0002722)4.16877575
6Recurrent bronchitis (HP:0002837)4.01282872
7Autoimmune thrombocytopenia (HP:0001973)3.83166702
8Recurrent bacterial skin infections (HP:0005406)3.73928377
9Recurrent viral infections (HP:0004429)3.60977776
10Nasal polyposis (HP:0100582)3.58065630
11Abnormality of the nasal mucosa (HP:0000433)3.57698233
12Thrombocytosis (HP:0001894)3.55540871
13Recurrent fungal infections (HP:0002841)3.54344087
14IgM deficiency (HP:0002850)3.48679859
15Orchitis (HP:0100796)3.23454480
16Vasculitis (HP:0002633)3.13379223
17Mediastinal lymphadenopathy (HP:0100721)3.10695866
18Recurrent gram-negative bacterial infections (HP:0005420)3.07365416
19Urticaria (HP:0001025)3.05848764
20Epistaxis (HP:0000421)2.95651091
21Neonatal hypoglycemia (HP:0001998)2.95509780
22Pustule (HP:0200039)2.95014203
23Abnormality of T cells (HP:0002843)2.94600634
24Prolonged bleeding time (HP:0003010)2.93596744
25Recurrent skin infections (HP:0001581)2.90625220
26Abnormality of T cell physiology (HP:0011840)2.89517988
27Stomatitis (HP:0010280)2.87885560
28Spontaneous hematomas (HP:0007420)2.87435055
29Retrobulbar optic neuritis (HP:0100654)2.85604345
30Optic neuritis (HP:0100653)2.85604345
31Abnormality of T cell number (HP:0011839)2.84852115
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.84058975
33Autoimmune hemolytic anemia (HP:0001890)2.83199359
34Meningitis (HP:0001287)2.83055361
35Gingival bleeding (HP:0000225)2.81763939
36Petechiae (HP:0000967)2.80160414
37Vacuolated lymphocytes (HP:0001922)2.79850468
38Chronic mucocutaneous candidiasis (HP:0002728)2.79067483
39Recurrent cutaneous fungal infections (HP:0011370)2.79067483
40Inflammation of the large intestine (HP:0002037)2.78300629
41Chest pain (HP:0100749)2.77210186
42T lymphocytopenia (HP:0005403)2.75232836
43Abnormality of macrophages (HP:0004311)2.75011062
44Agammaglobulinemia (HP:0004432)2.73117411
45Panhypogammaglobulinemia (HP:0003139)2.72563396
46Colitis (HP:0002583)2.71486497
47Increased IgE level (HP:0003212)2.70379982
48Systemic lupus erythematosus (HP:0002725)2.69650918
49Gastrointestinal inflammation (HP:0004386)2.68095444
50Interstitial pulmonary disease (HP:0006530)2.65146324
51Chronic sinusitis (HP:0011109)2.63779595
52Abnormality of glycolipid metabolism (HP:0010969)2.58577339
53Abnormality of liposaccharide metabolism (HP:0010968)2.58577339
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.58577339
55IgG deficiency (HP:0004315)2.57859375
56Cellulitis (HP:0100658)2.57003975
57Long foot (HP:0001833)2.56193884
58Abnormality of the pleura (HP:0002103)2.53164453
59Hypergammaglobulinemia (HP:0010702)2.50751440
60Gangrene (HP:0100758)2.49833558
61Hypochromic anemia (HP:0001931)2.46793322
62Episodic fever (HP:0001954)2.45811802
63Joint hemorrhage (HP:0005261)2.44972603
64Increased IgM level (HP:0003496)2.44369552
65IgA deficiency (HP:0002720)2.43859576
66Encephalitis (HP:0002383)2.43562508
67Eosinophilia (HP:0001880)2.42910289
68Leukocytosis (HP:0001974)2.42416473
69Granulocytopenia (HP:0001913)2.41644409
70Pulmonary infiltrates (HP:0002113)2.40789333
71Acute myeloid leukemia (HP:0004808)2.39622234
72Joint swelling (HP:0001386)2.39379333
73Arterial thrombosis (HP:0004420)2.37961227
74Lymphopenia (HP:0001888)2.37868117
75Abnormal platelet function (HP:0011869)2.36714810
76Impaired platelet aggregation (HP:0003540)2.36714810
77Periodontitis (HP:0000704)2.36068608
78Anorexia (HP:0002039)2.35869081
79Hemoptysis (HP:0002105)2.34118308
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.33612799
81Hematochezia (HP:0002573)2.32997950
82Loss of speech (HP:0002371)2.32588169
83Chronic diarrhea (HP:0002028)2.31543870
84Gastrointestinal infarctions (HP:0005244)2.30559144
85Dysostosis multiplex (HP:0000943)2.29584065
86Amyloidosis (HP:0011034)2.28458097
87Neoplasm of the adrenal cortex (HP:0100641)2.27829773
88Abnormality of B cell number (HP:0010975)2.27793837
89B lymphocytopenia (HP:0010976)2.27793837
90Purpura (HP:0000979)2.27195116
91Prolonged partial thromboplastin time (HP:0003645)2.27090809
92Increased cerebral lipofuscin (HP:0011813)2.20367724
93Keratoconjunctivitis sicca (HP:0001097)2.19259608
94Abnormality of eosinophils (HP:0001879)2.18550765
95Gastrointestinal stroma tumor (HP:0100723)2.18208580
96Malnutrition (HP:0004395)2.17930106
97Bronchitis (HP:0012387)2.17504635
98Restrictive lung disease (HP:0002091)2.17045785
99Peritonitis (HP:0002586)2.15617361
100Hypochromic microcytic anemia (HP:0004840)2.12651379
101Gingivitis (HP:0000230)2.12208160
102Severe combined immunodeficiency (HP:0004430)2.11546886
103Hypoplasia of the thymus (HP:0000778)2.11158201
104Reduced antithrombin III activity (HP:0001976)2.10671600
105Increased serum ferritin (HP:0003281)2.10291489
106Abnormality of the pericardium (HP:0001697)2.09639067
107Recurrent sinusitis (HP:0011108)2.08638832
108Basal ganglia calcification (HP:0002135)2.08225423
109Abnormality of the prostate (HP:0008775)2.07800553
110Microcytic anemia (HP:0001935)2.06902249
111Emphysema (HP:0002097)2.06860658
112Premature loss of primary teeth (HP:0006323)2.06774018
113Arthralgia (HP:0002829)2.06385193
114Combined immunodeficiency (HP:0005387)2.05281634
115Chronic obstructive pulmonary disease (HP:0006510)2.04905064
116Obstructive lung disease (HP:0006536)2.04905064
117Sepsis (HP:0100806)2.04037421
118Osteomyelitis (HP:0002754)2.01596533
119Keratoconjunctivitis (HP:0001096)2.00910050
120Skin rash (HP:0000988)2.00044926
121Polyneuropathy (HP:0001271)1.98857207
122Acne (HP:0001061)1.98840594
123Abnormality of the peritoneum (HP:0002585)1.98611658
124Skin ulcer (HP:0200042)1.97489128
125Myocardial infarction (HP:0001658)1.95455643
126Thyroiditis (HP:0100646)1.94035368
127Pulmonary embolism (HP:0002204)1.93284635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.86739766
2TYK23.41574292
3JAK32.91315969
4IKBKE2.84259217
5KIT2.78577544
6TBK12.76526485
7TXK2.65755780
8MAP3K142.52155489
9FGFR42.43718396
10BLK2.16766247
11ERN12.15981197
12IRAK42.15280546
13ZAP702.11568815
14JAK12.09874581
15TEC2.07599638
16STK161.98951792
17TGFBR21.98816156
18PRPF4B1.97490055
19NME21.92939797
20BTK1.90435725
21TNK21.84782713
22NLK1.83006365
23FLT31.82508727
24PRKG21.77979668
25IKBKB1.71960589
26CSF1R1.66208157
27IRAK31.60405233
28STK101.48704776
29MAPKAPK31.48703637
30KDR1.45223812
31FGFR31.42752381
32SYK1.37305404
33RPS6KA41.36838817
34FGR1.36806591
35TIE11.36299039
36PIM21.34602561
37EPHA31.33486916
38TAOK11.33333437
39TAOK31.29608679
40ITK1.28763178
41LCK1.28269808
42CSK1.20796032
43TGFBR11.20213409
44TESK21.18244570
45MAP3K101.14665509
46MAP2K31.11933535
47LRRK21.11690883
48MAP3K131.09425340
49NEK91.09227218
50CHUK1.06932674
51HCK1.06931609
52LYN1.06697507
53EPHB11.06196800
54MAP3K11.03793103
55GRK61.02213664
56TAOK21.01831252
57BMPR21.00828246
58PIM10.98998598
59MST40.98959429
60GRK70.98229257
61CDC42BPA0.97967621
62MAP3K120.95917765
63JAK20.90614491
64MATK0.87556815
65EEF2K0.84073626
66PRKD20.83019561
67MAP3K30.82697220
68PDK10.80534984
69RIPK10.80409478
70RIPK40.77833359
71TRIB30.76798019
72SIK10.74534355
73MAP2K60.72489434
74PTK2B0.70855267
75FES0.70077667
76MAPK70.69635025
77MARK20.69619771
78RPS6KB20.65148165
79MKNK20.62839836
80CLK10.62640101
81MAPK110.61897994
82PDPK10.61889295
83IRAK10.60176485
84SMG10.60109333
85HIPK20.58436464
86EIF2AK20.57986716
87MYLK0.57015699
88FYN0.56355983
89IRAK20.55223791
90YES10.54315741
91CAMKK10.52853361
92TRPM70.52517901
93BRSK20.52458212
94CAMKK20.52158317
95DAPK20.51667213
96PIK3CG0.51172982
97PTK60.48718943
98ACVR1B0.48217486
99MAPK40.48153520
100MAP3K20.47795577
101RPS6KA50.47378739
102MAP3K50.46356219
103KSR20.44972263
104MAP3K60.44887127
105MARK30.43717251
106MAP2K20.42858985
107BCKDK0.42220946
108MAPK150.41630162
109GRK10.41320263
110PRKCQ0.40808275
111INSRR0.38981535
112SIK20.38686245
113MAPKAPK20.38535291
114STK40.38176727
115MKNK10.38107179
116PRKCD0.37028763
117BMX0.36789059
118STK240.35740696
119SIK30.34768545
120ABL10.33894095
121RPS6KL10.33867702
122RPS6KC10.33867702
123ADRBK20.33448923
124RET0.32560748
125PKN20.31701582
126MAP3K110.31239765
127DYRK1B0.30255533
128CDK40.29132911
129IGF1R0.28862794
130MAPK120.27471342
131MAP3K70.27163995
132MAPK30.25081044
133TTN0.24587524
134EGFR0.24407679
135RPS6KA60.23970899
136PAK40.23585740
137CDK60.22741421

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33502368
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.66744228
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.66273795
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.55702601
5Staphylococcus aureus infection_Homo sapiens_hsa051502.53839098
6Leishmaniasis_Homo sapiens_hsa051402.51706654
7* Measles_Homo sapiens_hsa051622.46110176
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.41201162
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30976003
10Antigen processing and presentation_Homo sapiens_hsa046122.11477357
11Graft-versus-host disease_Homo sapiens_hsa053322.07418575
12Allograft rejection_Homo sapiens_hsa053302.02212760
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98165148
14Hematopoietic cell lineage_Homo sapiens_hsa046401.93383615
15* Herpes simplex infection_Homo sapiens_hsa051681.91561273
16B cell receptor signaling pathway_Homo sapiens_hsa046621.81390483
17* Osteoclast differentiation_Homo sapiens_hsa043801.76783991
18Caffeine metabolism_Homo sapiens_hsa002321.75507646
19Malaria_Homo sapiens_hsa051441.72058788
20African trypanosomiasis_Homo sapiens_hsa051431.71371096
21* Jak-STAT signaling pathway_Homo sapiens_hsa046301.68422608
22* Influenza A_Homo sapiens_hsa051641.63766656
23Ribosome_Homo sapiens_hsa030101.60722487
24Other glycan degradation_Homo sapiens_hsa005111.60409153
25Pertussis_Homo sapiens_hsa051331.60317884
26Legionellosis_Homo sapiens_hsa051341.60027941
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54711397
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50266378
29Complement and coagulation cascades_Homo sapiens_hsa046101.49129955
30Toxoplasmosis_Homo sapiens_hsa051451.43184350
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40534177
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39577340
33TNF signaling pathway_Homo sapiens_hsa046681.24900003
34T cell receptor signaling pathway_Homo sapiens_hsa046601.22681724
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22505813
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22193163
37Phagosome_Homo sapiens_hsa041451.21513140
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.17397227
39Apoptosis_Homo sapiens_hsa042101.17177211
40Tuberculosis_Homo sapiens_hsa051521.15635160
41* Hepatitis C_Homo sapiens_hsa051601.12607970
42Hepatitis B_Homo sapiens_hsa051611.08544710
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.07669012
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03669061
45Autoimmune thyroid disease_Homo sapiens_hsa053200.99693084
46Chemokine signaling pathway_Homo sapiens_hsa040620.99632031
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.99104627
48Acute myeloid leukemia_Homo sapiens_hsa052210.97774992
49Platelet activation_Homo sapiens_hsa046110.95698177
50ABC transporters_Homo sapiens_hsa020100.95135550
51Shigellosis_Homo sapiens_hsa051310.93795366
52Asthma_Homo sapiens_hsa053100.91865845
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89747277
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86916369
55Viral myocarditis_Homo sapiens_hsa054160.85141397
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81102518
57Folate biosynthesis_Homo sapiens_hsa007900.77238888
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76685560
59DNA replication_Homo sapiens_hsa030300.75024542
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74757287
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74748381
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.70903696
63Rheumatoid arthritis_Homo sapiens_hsa053230.70319377
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68825674
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68824022
66Salmonella infection_Homo sapiens_hsa051320.68189215
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68138681
68Lysosome_Homo sapiens_hsa041420.64708947
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62774314
70VEGF signaling pathway_Homo sapiens_hsa043700.62485646
71Histidine metabolism_Homo sapiens_hsa003400.62433384
72Peroxisome_Homo sapiens_hsa041460.61530515
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61502207
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59691213
75Tryptophan metabolism_Homo sapiens_hsa003800.58438129
76Endocytosis_Homo sapiens_hsa041440.56783050
77Base excision repair_Homo sapiens_hsa034100.56641092
78Chemical carcinogenesis_Homo sapiens_hsa052040.56562934
79Type I diabetes mellitus_Homo sapiens_hsa049400.56480021
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55986708
81Prolactin signaling pathway_Homo sapiens_hsa049170.55407503
82Selenocompound metabolism_Homo sapiens_hsa004500.55272490
83Epstein-Barr virus infection_Homo sapiens_hsa051690.53220739
84Small cell lung cancer_Homo sapiens_hsa052220.52916521
85Non-small cell lung cancer_Homo sapiens_hsa052230.51006401
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50817447
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50356114
88Pancreatic cancer_Homo sapiens_hsa052120.49526981
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.49492111
90Amoebiasis_Homo sapiens_hsa051460.48420140
91Sulfur relay system_Homo sapiens_hsa041220.48353015
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.46990640
93Pentose phosphate pathway_Homo sapiens_hsa000300.44232741
94Insulin resistance_Homo sapiens_hsa049310.43989892
95Notch signaling pathway_Homo sapiens_hsa043300.43659299
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43011147
97Proteasome_Homo sapiens_hsa030500.42523095
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41745840
99* Viral carcinogenesis_Homo sapiens_hsa052030.41590196
100Systemic lupus erythematosus_Homo sapiens_hsa053220.41183055
101Non-homologous end-joining_Homo sapiens_hsa034500.40823372
102Fatty acid degradation_Homo sapiens_hsa000710.39738896
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38756245
104Lysine degradation_Homo sapiens_hsa003100.38716097
105HTLV-I infection_Homo sapiens_hsa051660.38569772
106Retinol metabolism_Homo sapiens_hsa008300.38381430
107Chronic myeloid leukemia_Homo sapiens_hsa052200.38212111
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.38099678
109Pyrimidine metabolism_Homo sapiens_hsa002400.37278574
110One carbon pool by folate_Homo sapiens_hsa006700.36909847
111p53 signaling pathway_Homo sapiens_hsa041150.36417616
112Mismatch repair_Homo sapiens_hsa034300.36163732
113PPAR signaling pathway_Homo sapiens_hsa033200.35424828
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35404227
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.34776975
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.34599977
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34052677
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33534707
119Arachidonic acid metabolism_Homo sapiens_hsa005900.33180238
120FoxO signaling pathway_Homo sapiens_hsa040680.32006231
121Choline metabolism in cancer_Homo sapiens_hsa052310.31060929
122Dorso-ventral axis formation_Homo sapiens_hsa043200.30986223
123GnRH signaling pathway_Homo sapiens_hsa049120.29642308
124Type II diabetes mellitus_Homo sapiens_hsa049300.29150276
125Renal cell carcinoma_Homo sapiens_hsa052110.28817365
126Regulation of autophagy_Homo sapiens_hsa041400.28129775
127MAPK signaling pathway_Homo sapiens_hsa040100.27306742
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26404447
129Collecting duct acid secretion_Homo sapiens_hsa049660.24890535
130HIF-1 signaling pathway_Homo sapiens_hsa040660.23000624
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22508061
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22085032
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20821818
134mTOR signaling pathway_Homo sapiens_hsa041500.19520297

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