IRGC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)8.74061348
2sperm capacitation (GO:0048240)8.60078189
3protein polyglutamylation (GO:0018095)8.41564990
4plasma membrane fusion (GO:0045026)8.11144766
5microtubule depolymerization (GO:0007019)8.00673553
6protein targeting to Golgi (GO:0000042)7.67400229
7chromosome condensation (GO:0030261)7.65983056
8rRNA methylation (GO:0031167)7.60444012
9DNA packaging (GO:0006323)7.57680640
10multicellular organism reproduction (GO:0032504)7.35428427
11establishment of protein localization to Golgi (GO:0072600)7.34726430
12phosphatidylethanolamine biosynthetic process (GO:0006646)7.29245465
13sperm-egg recognition (GO:0035036)7.17731242
14retrograde transport, vesicle recycling within Golgi (GO:0000301)7.17293922
15microtubule polymerization or depolymerization (GO:0031109)6.95449779
16phosphatidylethanolamine metabolic process (GO:0046337)6.69658775
17single strand break repair (GO:0000012)6.59911454
18rRNA modification (GO:0000154)6.51944888
19reproduction (GO:0000003)6.50892848
20spermatogenesis (GO:0007283)6.48372742
21male gamete generation (GO:0048232)6.46062560
22binding of sperm to zona pellucida (GO:0007339)6.35324354
23centriole replication (GO:0007099)6.30899020
24calcium ion-dependent exocytosis (GO:0017156)6.30857794
25spermatid nucleus differentiation (GO:0007289)6.27961259
26seminiferous tubule development (GO:0072520)6.26147532
27axonemal dynein complex assembly (GO:0070286)6.17247395
28cell-cell recognition (GO:0009988)6.00991383
29negative regulation of inclusion body assembly (GO:0090084)5.95778175
30gamete generation (GO:0007276)5.95645727
31microtubule severing (GO:0051013)5.93140896
32centriole assembly (GO:0098534)5.78872805
33cilium or flagellum-dependent cell motility (GO:0001539)5.74219557
34protein localization to Golgi apparatus (GO:0034067)5.63493797
35RNA destabilization (GO:0050779)5.53038291
36response to pheromone (GO:0019236)5.48946754
37single fertilization (GO:0007338)5.47733442
38regulation of centriole replication (GO:0046599)5.31458284
39motile cilium assembly (GO:0044458)5.25472604
40sexual reproduction (GO:0019953)5.14891116
41regulation of cilium movement (GO:0003352)5.08953340
42epithelial cilium movement (GO:0003351)4.93058720
43cellular ketone body metabolic process (GO:0046950)4.91407503
44germ cell development (GO:0007281)4.87674093
45multicellular organismal reproductive process (GO:0048609)4.76616024
46fertilization (GO:0009566)4.73227593
47positive regulation of Rab GTPase activity (GO:0032851)4.68573734
48regulation of Rab GTPase activity (GO:0032313)4.68573734
49regulation of transcription involved in cell fate commitment (GO:0060850)4.65808120
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.49744147
51organic cation transport (GO:0015695)4.44286223
52ketone body metabolic process (GO:1902224)4.31900006
53cilium movement (GO:0003341)4.26536081
54regulation of inclusion body assembly (GO:0090083)4.24570494
55glomerular visceral epithelial cell development (GO:0072015)4.22621578
56cell wall macromolecule catabolic process (GO:0016998)4.20065965
57cell wall macromolecule metabolic process (GO:0044036)4.09133870
58microtubule nucleation (GO:0007020)4.02367285
59musculoskeletal movement (GO:0050881)4.02242712
60multicellular organismal movement (GO:0050879)4.02242712
61glycerol ether metabolic process (GO:0006662)3.97849123
62glomerular epithelial cell development (GO:0072310)3.95458768
63piRNA metabolic process (GO:0034587)3.87404301
64nucleus organization (GO:0006997)3.84770966
65ether metabolic process (GO:0018904)3.66280370
66membrane protein intracellular domain proteolysis (GO:0031293)3.60562669
67polyamine biosynthetic process (GO:0006596)3.53296637
68regulation of microtubule-based movement (GO:0060632)3.49822345
69Golgi to endosome transport (GO:0006895)3.39397735
70response to acidic pH (GO:0010447)3.37901087
71regulation of phosphoprotein phosphatase activity (GO:0043666)3.37587582
72cellular response to pH (GO:0071467)3.37131951
73axoneme assembly (GO:0035082)3.26956392
74ventricular system development (GO:0021591)3.20796839
75chromatin silencing (GO:0006342)3.20554456
76multicellular organismal development (GO:0007275)3.20025441
77centrosome duplication (GO:0051298)3.17322040
78nuclear pore complex assembly (GO:0051292)3.16629584
79male meiosis (GO:0007140)3.14159048
80male meiosis I (GO:0007141)3.13385781
81mitochondrial fission (GO:0000266)3.11424437
82nucleosome disassembly (GO:0006337)3.03778471
83protein-DNA complex disassembly (GO:0032986)3.03778471
84positive regulation of guanylate cyclase activity (GO:0031284)3.03750326
85regulation of guanylate cyclase activity (GO:0031282)2.91937952
86protein depolymerization (GO:0051261)2.90728188
87RNA localization (GO:0006403)2.88456774
88coenzyme catabolic process (GO:0009109)2.85543667
89cell recognition (GO:0008037)2.83533953
90peptidyl-threonine dephosphorylation (GO:0035970)2.83397937
91RNA methylation (GO:0001510)2.82511613
92peptidyl-glutamic acid modification (GO:0018200)2.82123521
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.81674956
94cerebral cortex neuron differentiation (GO:0021895)2.79397140
95regulation of meiosis I (GO:0060631)2.79386527
96intra-Golgi vesicle-mediated transport (GO:0006891)2.78887376
97DNA methylation involved in gamete generation (GO:0043046)2.77492016
98sperm motility (GO:0030317)12.5120531
99acrosome reaction (GO:0007340)11.1153646
100fusion of sperm to egg plasma membrane (GO:0007342)10.6691810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65576166
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.46707723
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.40747598
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.34721183
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43122733
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43122733
7FUS_26573619_Chip-Seq_HEK293_Human2.42182517
8EZH2_22144423_ChIP-Seq_EOC_Human2.40451897
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21387526
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.19661496
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18851015
12CBP_20019798_ChIP-Seq_JUKART_Human2.15969169
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.15969169
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15220931
15DROSHA_22980978_ChIP-Seq_HELA_Human1.95804491
16RAC3_21632823_ChIP-Seq_H3396_Human1.94195534
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.80349214
18NANOG_20526341_ChIP-Seq_ESCs_Human1.79680454
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.77798646
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.73794523
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73332703
22CTCF_27219007_Chip-Seq_Bcells_Human1.72900891
23ERA_21632823_ChIP-Seq_H3396_Human1.69299860
24BCL6_27268052_Chip-Seq_Bcells_Human1.63758237
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62055159
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.59865701
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.59755449
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.56628567
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56386571
30P68_20966046_ChIP-Seq_HELA_Human1.56193895
31ER_23166858_ChIP-Seq_MCF-7_Human1.56122475
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53244065
33* MYC_19829295_ChIP-Seq_ESCs_Human1.53173092
34TAF2_19829295_ChIP-Seq_ESCs_Human1.52060032
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.49508350
36SMC4_20622854_ChIP-Seq_HELA_Human1.47310797
37OCT4_20526341_ChIP-Seq_ESCs_Human1.46872999
38CTCF_20526341_ChIP-Seq_ESCs_Human1.45560839
39ERG_20517297_ChIP-Seq_VCAP_Human1.45030584
40E2F1_20622854_ChIP-Seq_HELA_Human1.44644333
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43962961
42BCOR_27268052_Chip-Seq_Bcells_Human1.42929542
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40882780
44* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40701880
45PHF8_20622854_ChIP-Seq_HELA_Human1.40137608
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37592589
47CBX2_22325352_ChIP-Seq_293T-Rex_Human1.37347037
48RBPJ_21746931_ChIP-Seq_IB4_Human1.37052217
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34959735
50HNFA_21074721_ChIP-Seq_CACO-2_Human1.34169191
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31389114
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30998324
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30668647
54AR_25329375_ChIP-Seq_VCAP_Human1.30498555
55ETV1_20927104_ChIP-Seq_GIST48_Human1.30442227
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.29102423
57TP63_22573176_ChIP-Seq_HFKS_Human1.28058937
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27821468
59TP53_18474530_ChIP-ChIP_U2OS_Human1.27812130
60P300_27268052_Chip-Seq_Bcells_Human1.27794112
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.27433929
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.23541108
63P300_19829295_ChIP-Seq_ESCs_Human1.23174466
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22420678
65NFYB_21822215_ChIP-Seq_K562_Human1.20456441
66GBX2_23144817_ChIP-Seq_PC3_Human1.19834407
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19487436
68CEBPB_22108803_ChIP-Seq_LS180_Human1.18994114
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.18660626
70TBL1_22424771_ChIP-Seq_293T_Human1.18422263
71PHF8_20622853_ChIP-Seq_HELA_Human1.16958855
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15343200
73LXR_22292898_ChIP-Seq_THP-1_Human1.15193957
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13028914
75SMAD4_21799915_ChIP-Seq_A2780_Human1.11995693
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11110038
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09320043
78* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09102120
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07782060
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07355977
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.07300605
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.06944215
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05691850
84AR_21572438_ChIP-Seq_LNCaP_Human1.05511499
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05289326
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04831748
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04328534
88KLF4_19829295_ChIP-Seq_ESCs_Human1.02717098
89NFYA_21822215_ChIP-Seq_K562_Human1.02227117
90P53_21459846_ChIP-Seq_SAOS-2_Human1.01636820
91* STAT3_23295773_ChIP-Seq_U87_Human1.00706420
92TAF15_26573619_Chip-Seq_HEK293_Human1.00399857
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.00341844
94SMRT_27268052_Chip-Seq_Bcells_Human1.00086306
95VDR_22108803_ChIP-Seq_LS180_Human0.99641300
96RUNX2_22187159_ChIP-Seq_PCA_Human0.98583787
97SOX2_19829295_ChIP-Seq_ESCs_Human0.98115115
98NANOG_19829295_ChIP-Seq_ESCs_Human0.98115115
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98056675
100RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98007632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.08459942
2MP0003878_abnormal_ear_physiology5.39900605
3MP0005377_hearing/vestibular/ear_phenot5.39900605
4MP0003698_abnormal_male_reproductive4.36038402
5MP0001929_abnormal_gametogenesis3.95741615
6MP0001348_abnormal_lacrimal_gland2.83178280
7MP0002161_abnormal_fertility/fecundity2.40827380
8MP0001485_abnormal_pinna_reflex2.34523592
9MP0005410_abnormal_fertilization11.7462624
10MP0002210_abnormal_sex_determination1.95810141
11MP0003718_maternal_effect1.82211378
12MP0005310_abnormal_salivary_gland1.81960711
13MP0003879_abnormal_hair_cell1.75391369
14MP0003646_muscle_fatigue1.75021997
15MP0000678_abnormal_parathyroid_gland1.73732334
16MP0005423_abnormal_somatic_nervous1.60695310
17MP0001145_abnormal_male_reproductive1.57677437
18MP0000653_abnormal_sex_gland1.51516693
19MP0001486_abnormal_startle_reflex1.49935878
20MP0002138_abnormal_hepatobiliary_system1.39867147
21MP0002282_abnormal_trachea_morphology1.36162704
22MP0003011_delayed_dark_adaptation1.34121048
23MP0002132_abnormal_respiratory_system1.33849458
24MP0009053_abnormal_anal_canal1.33799320
25MP0001963_abnormal_hearing_physiology1.33066749
26MP0005451_abnormal_body_composition1.31686470
27MP0002822_catalepsy1.25817221
28MP0005551_abnormal_eye_electrophysiolog1.22133391
29MP0001968_abnormal_touch/_nociception1.20407851
30MP0000013_abnormal_adipose_tissue1.17701027
31MP0005379_endocrine/exocrine_gland_phen1.16743705
32MP0001765_abnormal_ion_homeostasis1.15213142
33MP0005367_renal/urinary_system_phenotyp1.14144586
34MP0000516_abnormal_urinary_system1.14144586
35MP0009115_abnormal_fat_cell1.07254295
36MP0002234_abnormal_pharynx_morphology1.05773077
37MP0002249_abnormal_larynx_morphology1.05115189
38MP0002735_abnormal_chemical_nociception1.01366359
39MP0004859_abnormal_synaptic_plasticity1.01025529
40MP0005253_abnormal_eye_physiology1.00423182
41MP0000026_abnormal_inner_ear1.00288206
42MP0000534_abnormal_ureter_morphology1.00068564
43MP0004742_abnormal_vestibular_system0.99288196
44MP0001905_abnormal_dopamine_level0.95174959
45MP0005666_abnormal_adipose_tissue0.93607578
46MP0002928_abnormal_bile_duct0.93123293
47MP0000681_abnormal_thyroid_gland0.92204010
48MP0008569_lethality_at_weaning0.84088960
49MP0002229_neurodegeneration0.83423194
50MP0002127_abnormal_cardiovascular_syste0.80346577
51MP0000049_abnormal_middle_ear0.76901273
52MP0000003_abnormal_adipose_tissue0.72066949
53MP0005395_other_phenotype0.71488524
54MP0009697_abnormal_copulation0.69441045
55MP0002067_abnormal_sensory_capabilities0.69343726
56MP0004510_myositis0.65100723
57MP0005167_abnormal_blood-brain_barrier0.64385353
58MP0005375_adipose_tissue_phenotype0.62200853
59MP0000955_abnormal_spinal_cord0.61811489
60MP0000230_abnormal_systemic_arterial0.60801027
61MP0006292_abnormal_olfactory_placode0.58647317
62MP0002733_abnormal_thermal_nociception0.57222823
63MP0002557_abnormal_social/conspecific_i0.57013791
64MP0001984_abnormal_olfaction0.55466733
65MP0008877_abnormal_DNA_methylation0.55454842
66MP0002572_abnormal_emotion/affect_behav0.54257821
67MP0002272_abnormal_nervous_system0.53553092
68MP0005636_abnormal_mineral_homeostasis0.53401368
69MP0005083_abnormal_biliary_tract0.50682681
70MP0008995_early_reproductive_senescence0.50584050
71MP0005084_abnormal_gallbladder_morpholo0.50068361
72MP0002160_abnormal_reproductive_system0.49563569
73MP0001661_extended_life_span0.49121153
74MP0004085_abnormal_heartbeat0.48898569
75MP0003172_abnormal_lysosome_physiology0.47693881
76MP0000470_abnormal_stomach_morphology0.46154693
77MP0009745_abnormal_behavioral_response0.45582920
78MP0001970_abnormal_pain_threshold0.43962676
79MP0005391_vision/eye_phenotype0.43923062
80MP0004782_abnormal_surfactant_physiolog0.43475810
81MP0003631_nervous_system_phenotype0.42429312
82MP0003119_abnormal_digestive_system0.41588151
83MP0003699_abnormal_female_reproductive0.41489177
84MP0001270_distended_abdomen0.40981122
85MP0005397_hematopoietic_system_phenotyp0.40814086
86MP0001545_abnormal_hematopoietic_system0.40814086
87MP0003077_abnormal_cell_cycle0.40793728
88MP0005248_abnormal_Harderian_gland0.40358940
89MP0003724_increased_susceptibility_to0.40064056
90MP0005332_abnormal_amino_acid0.39298745
91MP0001501_abnormal_sleep_pattern0.39172172
92MP0010329_abnormal_lipoprotein_level0.39014655
93MP0005647_abnormal_sex_gland0.38943852
94MP0003936_abnormal_reproductive_system0.38786634
95MP0001849_ear_inflammation0.37551246
96MP0005535_abnormal_body_temperature0.36927275
97MP0003137_abnormal_impulse_conducting0.34745664
98MP0002734_abnormal_mechanical_nocicepti0.34602434
99MP0003635_abnormal_synaptic_transmissio0.34417507
100MP0001440_abnormal_grooming_behavior0.34405932

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.75498018
2Chronic hepatic failure (HP:0100626)6.56165234
3Absent/shortened dynein arms (HP:0200106)6.12327629
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.12327629
5Tubulointerstitial nephritis (HP:0001970)6.04656064
6Asymmetric septal hypertrophy (HP:0001670)5.71434923
7Attenuation of retinal blood vessels (HP:0007843)5.07094544
8Bony spicule pigmentary retinopathy (HP:0007737)4.86417426
9Hypoalphalipoproteinemia (HP:0003233)4.77763034
10Abnormal ciliary motility (HP:0012262)4.50557767
11Abnormal respiratory motile cilium physiology (HP:0012261)4.45648667
12Hyperkalemia (HP:0002153)4.37427816
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.33867676
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.30204027
15Male infertility (HP:0003251)4.20936259
16Cone-rod dystrophy (HP:0000548)4.18512923
17Resting tremor (HP:0002322)4.17381363
18Infertility (HP:0000789)4.10695060
19Abnormal respiratory epithelium morphology (HP:0012253)4.09462351
20Abnormal respiratory motile cilium morphology (HP:0005938)4.09462351
21Abnormality of macular pigmentation (HP:0008002)4.07438048
22Nasal polyposis (HP:0100582)3.90283298
23Menstrual irregularities (HP:0000858)3.69885273
24Insulin-resistant diabetes mellitus (HP:0000831)3.65457734
25Abnormal rod and cone electroretinograms (HP:0008323)3.46943495
26Hypoplasia of the thymus (HP:0000778)3.46280776
27Abnormality of dental color (HP:0011073)3.39879384
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.28843864
29Amelogenesis imperfecta (HP:0000705)3.20122826
30Impulsivity (HP:0100710)3.17786715
31Bell-shaped thorax (HP:0001591)3.14970970
32Abnormality of the nasal mucosa (HP:0000433)3.13004951
33Portal hypertension (HP:0001409)3.09982741
34Potter facies (HP:0002009)3.09862271
35Facial shape deformation (HP:0011334)3.09862271
36Postural instability (HP:0002172)3.05528183
37Truncal obesity (HP:0001956)3.03170119
38Hyperuricemia (HP:0002149)3.01374130
39Increased purine levels (HP:0004368)3.01374130
40Progressive sensorineural hearing impairment (HP:0000408)3.00521659
41Abnormality of the hepatic vasculature (HP:0006707)2.98411844
42Progressive cerebellar ataxia (HP:0002073)2.94890586
43Renovascular hypertension (HP:0100817)2.93484492
44Abnormality of the costochondral junction (HP:0000919)2.93480797
45Enlarged epiphyses (HP:0010580)2.87938706
46Tubulointerstitial abnormality (HP:0001969)2.77020730
47Nephronophthisis (HP:0000090)2.75895244
48Rhinitis (HP:0012384)2.62713897
49Stage 5 chronic kidney disease (HP:0003774)2.56808069
50Abnormal urine output (HP:0012590)2.50212603
51Abnormal drinking behavior (HP:0030082)2.45910952
52Polydipsia (HP:0001959)2.45910952
53Hypolipoproteinemia (HP:0010981)2.42154091
54Generalized aminoaciduria (HP:0002909)2.41070053
55Subcapsular cataract (HP:0000523)2.40334209
56Hypoplastic ischia (HP:0003175)2.40030945
57Abnormal spermatogenesis (HP:0008669)2.35911567
58Decreased central vision (HP:0007663)2.35733864
59Focal segmental glomerulosclerosis (HP:0000097)2.29885273
60Occipital encephalocele (HP:0002085)2.29684351
61Congenital sensorineural hearing impairment (HP:0008527)2.28627784
62Abnormality of the renal medulla (HP:0100957)2.28060321
63Intellectual disability, moderate (HP:0002342)2.26143036
64Abnormality of potassium homeostasis (HP:0011042)2.24644329
65Abnormality of the ischium (HP:0003174)2.16673279
66Insulin resistance (HP:0000855)2.14037300
67Osteomalacia (HP:0002749)2.12749202
68Abnormality of renal excretion (HP:0011036)2.12492416
69Renal Fanconi syndrome (HP:0001994)2.11585166
70Chronic bronchitis (HP:0004469)2.07380102
71Renal dysplasia (HP:0000110)2.06646987
72Recurrent pneumonia (HP:0006532)2.05794061
73Polyuria (HP:0000103)2.03451868
74Bronchiectasis (HP:0002110)2.03398844
75Cerebellar dysplasia (HP:0007033)2.01117056
76Photophobia (HP:0000613)1.96476983
77Hypoalbuminemia (HP:0003073)1.95347744
78Abnormal albumin level (HP:0012116)1.95347744
79Hypophosphatemic rickets (HP:0004912)1.94292982
80Abnormality of purine metabolism (HP:0004352)1.88952739
81Abnormality of the epiphysis of the femoral head (HP:0010574)1.87312908
82Recurrent corneal erosions (HP:0000495)1.85556527
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84253042
84Azoospermia (HP:0000027)1.84033252
85Flattened epiphyses (HP:0003071)1.84019199
86Glycosuria (HP:0003076)1.83191932
87Abnormality of urine glucose concentration (HP:0011016)1.83191932
88Myokymia (HP:0002411)1.82744269
89Progressive hearing impairment (HP:0001730)1.80860189
90Glomerulosclerosis (HP:0000096)1.78827661
91Hyponatremia (HP:0002902)1.76952487
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76625876
93Absent epiphyses (HP:0010577)1.76625876
94Abnormality of the femoral head (HP:0003368)1.73592837
95Acanthosis nigricans (HP:0000956)1.72774694
96Widely patent fontanelles and sutures (HP:0004492)1.72735451
97Hypertriglyceridemia (HP:0002155)1.72488667
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.70871902
99Abnormality of femoral epiphyses (HP:0006499)1.70871902
100Type II diabetes mellitus (HP:0005978)1.70805833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.44114810
2TESK14.42661212
3INSRR4.16761487
4BRD43.62562406
5PLK23.41627770
6DDR23.39505157
7STK383.01000040
8PNCK2.86356980
9MAPK152.44920356
10MAP4K22.36720606
11PRKD32.36318690
12STK38L2.35681107
13PIK3CG2.20271137
14TAF12.14839812
15CAMK1G2.14748912
16PDPK11.47964144
17MST1R1.47750463
18PDK11.44912972
19NEK61.37076187
20TYRO31.33304576
21LATS11.27266415
22PINK11.22072600
23DYRK1B1.10013106
24WNK11.09011373
25AKT31.07348101
26CDK121.05377112
27SIK20.96550507
28KSR20.96405767
29BRAF0.88726744
30PTK2B0.88085155
31PRKG20.86351611
32MAP3K90.81856573
33RPS6KA20.79597932
34CDK70.79278687
35RIPK40.74354656
36TIE10.73412564
37ARAF0.71724407
38DAPK20.71587670
39MAP3K110.66559243
40RPS6KC10.65708708
41RPS6KL10.65708708
42RPS6KA10.63018866
43SGK4940.61813066
44SGK2230.61813066
45RPS6KA60.60321723
46JAK30.59651059
47MARK30.58216387
48WNK40.57500337
49CAMK1D0.55996437
50PRKG10.54781988
51NUAK10.50651661
52TESK20.47107815
53CDK90.45838145
54CAMK10.44169919
55MAP3K20.43688993
56CDK30.43193971
57STK390.42423440
58MAP2K10.42024634
59MAPK10.40657883
60MAP2K20.39972224
61BRSK10.39583678
62ROCK10.38831512
63MUSK0.38119772
64GSK3B0.37629390
65KIT0.36515210
66MAP3K10.36225972
67CDK20.34977083
68PRKAA20.34928616
69SGK20.30912400
70FLT30.30549291
71MAP3K70.30060949
72CDK10.28260684
73MAPK80.26892485
74ADRBK20.26588134
75SGK10.23440026
76PRKCG0.23110045
77VRK10.21653009
78MAP3K40.19737323
79UHMK10.19468488
80MAP3K80.18997657
81MAPK110.18947165
82PRKCH0.18566075
83GRK10.18351057
84PRKCB0.17603370
85MTOR0.16159198
86MAP2K70.16071055
87NTRK30.16000951
88MAPK140.15885880
89BLK0.15195987
90FRK0.14613426
91TXK0.14068724
92PRKCZ0.13181607
93MAPK100.12487118
94LATS20.12390107
95TLK10.11530140
96NEK20.11407519
97MAPKAPK50.11090918
98RPS6KA50.10619929
99BMPR1B0.09657026
100SGK30.09467154

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.21185899
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.43842676
3Olfactory transduction_Homo sapiens_hsa047403.88789032
4Dorso-ventral axis formation_Homo sapiens_hsa043202.42475833
5Butanoate metabolism_Homo sapiens_hsa006502.41185709
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.25754305
7Fatty acid degradation_Homo sapiens_hsa000711.91714833
8Taste transduction_Homo sapiens_hsa047421.81644530
9Phenylalanine metabolism_Homo sapiens_hsa003601.79185241
10RNA transport_Homo sapiens_hsa030131.72584918
11Fatty acid metabolism_Homo sapiens_hsa012121.63768588
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59800018
13Phototransduction_Homo sapiens_hsa047441.54476056
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44509312
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41971231
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39692362
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.37007718
18Hedgehog signaling pathway_Homo sapiens_hsa043401.28229968
19Selenocompound metabolism_Homo sapiens_hsa004501.27671461
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19038560
21ABC transporters_Homo sapiens_hsa020101.14902790
22PPAR signaling pathway_Homo sapiens_hsa033201.11607952
23Nitrogen metabolism_Homo sapiens_hsa009101.10844806
24Type II diabetes mellitus_Homo sapiens_hsa049301.04381319
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02452123
26Calcium signaling pathway_Homo sapiens_hsa040201.02316508
27Salivary secretion_Homo sapiens_hsa049701.00586663
28Maturity onset diabetes of the young_Homo sapiens_hsa049500.93568722
29Glycerolipid metabolism_Homo sapiens_hsa005610.91240491
30Type I diabetes mellitus_Homo sapiens_hsa049400.91084387
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89247780
32Arginine biosynthesis_Homo sapiens_hsa002200.88361770
33Morphine addiction_Homo sapiens_hsa050320.88329022
34Protein digestion and absorption_Homo sapiens_hsa049740.88180722
35Synaptic vesicle cycle_Homo sapiens_hsa047210.87012036
36Nicotine addiction_Homo sapiens_hsa050330.85899013
37Basal transcription factors_Homo sapiens_hsa030220.82085425
38Antigen processing and presentation_Homo sapiens_hsa046120.81496031
39Inositol phosphate metabolism_Homo sapiens_hsa005620.80348730
40Tyrosine metabolism_Homo sapiens_hsa003500.78406051
41Circadian entrainment_Homo sapiens_hsa047130.75410311
42cAMP signaling pathway_Homo sapiens_hsa040240.75046876
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74108014
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73733208
45Glutamatergic synapse_Homo sapiens_hsa047240.71946819
46Renin secretion_Homo sapiens_hsa049240.68627966
47Endocytosis_Homo sapiens_hsa041440.67526788
48Autoimmune thyroid disease_Homo sapiens_hsa053200.67236280
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66048403
50Arginine and proline metabolism_Homo sapiens_hsa003300.65703947
51Graft-versus-host disease_Homo sapiens_hsa053320.64651849
52Allograft rejection_Homo sapiens_hsa053300.64393440
53Renin-angiotensin system_Homo sapiens_hsa046140.64379839
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64176484
55Fat digestion and absorption_Homo sapiens_hsa049750.63743843
56VEGF signaling pathway_Homo sapiens_hsa043700.62524963
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.61276662
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.60070422
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59984551
60Pancreatic secretion_Homo sapiens_hsa049720.59557383
61Gastric acid secretion_Homo sapiens_hsa049710.59260623
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58787356
63Influenza A_Homo sapiens_hsa051640.57705317
64beta-Alanine metabolism_Homo sapiens_hsa004100.54469902
65Cardiac muscle contraction_Homo sapiens_hsa042600.53395829
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53169193
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52928393
68Serotonergic synapse_Homo sapiens_hsa047260.52458701
69Purine metabolism_Homo sapiens_hsa002300.51319402
70Oocyte meiosis_Homo sapiens_hsa041140.50380735
71MAPK signaling pathway_Homo sapiens_hsa040100.50136466
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50004132
73Gap junction_Homo sapiens_hsa045400.47181458
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46423526
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46365064
76Cholinergic synapse_Homo sapiens_hsa047250.43464923
77Long-term potentiation_Homo sapiens_hsa047200.42877538
78Fanconi anemia pathway_Homo sapiens_hsa034600.40948746
79Oxytocin signaling pathway_Homo sapiens_hsa049210.40825780
80Retinol metabolism_Homo sapiens_hsa008300.40365216
81Linoleic acid metabolism_Homo sapiens_hsa005910.40072082
82Bile secretion_Homo sapiens_hsa049760.39505394
83Viral myocarditis_Homo sapiens_hsa054160.39468793
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.38155609
85mRNA surveillance pathway_Homo sapiens_hsa030150.33498166
86Insulin secretion_Homo sapiens_hsa049110.33397841
87Estrogen signaling pathway_Homo sapiens_hsa049150.31975253
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31905040
89Chemical carcinogenesis_Homo sapiens_hsa052040.31212563
90T cell receptor signaling pathway_Homo sapiens_hsa046600.31186800
91Amphetamine addiction_Homo sapiens_hsa050310.29068331
92B cell receptor signaling pathway_Homo sapiens_hsa046620.28035337
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25914848
94Tryptophan metabolism_Homo sapiens_hsa003800.25163962
95GABAergic synapse_Homo sapiens_hsa047270.24436770
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21935698
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.21589828
98Huntingtons disease_Homo sapiens_hsa050160.21090018
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19808553
100Biosynthesis of amino acids_Homo sapiens_hsa012300.19630440

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