IRGM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.37514061
2DNA methylation involved in gamete generation (GO:0043046)4.48615820
3male meiosis I (GO:0007141)4.40801647
4multicellular organism reproduction (GO:0032504)4.37268948
5L-fucose catabolic process (GO:0042355)4.25437795
6fucose catabolic process (GO:0019317)4.25437795
7L-fucose metabolic process (GO:0042354)4.25437795
8regulation of female gonad development (GO:2000194)4.23629961
9regulation of meiosis I (GO:0060631)3.99454726
10retinal cone cell development (GO:0046549)3.97639391
11regulation of acrosome reaction (GO:0060046)3.93854368
12DNA deamination (GO:0045006)3.83776783
13tryptophan catabolic process (GO:0006569)3.79468405
14indole-containing compound catabolic process (GO:0042436)3.79468405
15indolalkylamine catabolic process (GO:0046218)3.79468405
16behavioral response to nicotine (GO:0035095)3.73107787
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68703628
18kynurenine metabolic process (GO:0070189)3.63913698
19platelet dense granule organization (GO:0060155)3.62948658
20indolalkylamine metabolic process (GO:0006586)3.57879097
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51230824
22tryptophan metabolic process (GO:0006568)3.45818955
23meiosis I (GO:0007127)3.43631266
24epithelial cilium movement (GO:0003351)3.43045538
25preassembly of GPI anchor in ER membrane (GO:0016254)3.42873016
26neural tube formation (GO:0001841)3.41448837
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40616250
28negative regulation of mast cell activation (GO:0033004)3.33258062
29positive regulation of defense response to virus by host (GO:0002230)3.32286699
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31832447
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.31832447
32NADH dehydrogenase complex assembly (GO:0010257)3.31832447
33protein K6-linked ubiquitination (GO:0085020)3.25275972
34ubiquinone biosynthetic process (GO:0006744)3.23707908
35meiotic cell cycle (GO:0051321)3.23055698
36axoneme assembly (GO:0035082)3.16834904
37protein complex biogenesis (GO:0070271)3.10937696
38detection of light stimulus involved in sensory perception (GO:0050962)3.07717920
39detection of light stimulus involved in visual perception (GO:0050908)3.07717920
40male meiosis (GO:0007140)3.02444192
41nonmotile primary cilium assembly (GO:0035058)3.01239858
42reflex (GO:0060004)3.00490741
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99116239
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99116239
45response to pheromone (GO:0019236)2.98986502
46positive regulation of histone H3-K4 methylation (GO:0051571)2.98353329
47ubiquinone metabolic process (GO:0006743)2.98010803
48regulation of collateral sprouting (GO:0048670)2.96772007
49synapsis (GO:0007129)2.96001981
50mannosylation (GO:0097502)2.95665238
51C-terminal protein amino acid modification (GO:0018410)2.84744926
52indole-containing compound metabolic process (GO:0042430)2.83862988
53centriole replication (GO:0007099)2.82465816
54gene silencing by RNA (GO:0031047)2.82064783
55cellular ketone body metabolic process (GO:0046950)2.80920881
56mitochondrial respiratory chain complex assembly (GO:0033108)2.80734970
57negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78865543
58photoreceptor cell maintenance (GO:0045494)2.78150171
59C-terminal protein lipidation (GO:0006501)2.76502273
60reciprocal meiotic recombination (GO:0007131)2.71869938
61reciprocal DNA recombination (GO:0035825)2.71869938
62cellular biogenic amine catabolic process (GO:0042402)2.70507691
63amine catabolic process (GO:0009310)2.70507691
64chromosome organization involved in meiosis (GO:0070192)2.69726895
65quinone biosynthetic process (GO:1901663)2.69196688
66cilium movement (GO:0003341)2.68963020
67neuronal action potential (GO:0019228)2.67670415
68glycine transport (GO:0015816)2.67040411
69cornea development in camera-type eye (GO:0061303)2.65536080
70protein localization to cilium (GO:0061512)2.63869300
71photoreceptor cell development (GO:0042461)2.62702658
72regulation of cilium movement (GO:0003352)2.62596299
73reproduction (GO:0000003)2.61404527
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.60614927
75termination of RNA polymerase III transcription (GO:0006386)2.60614927
76GPI anchor metabolic process (GO:0006505)2.58770539
77cilium morphogenesis (GO:0060271)2.58623053
78positive regulation of meiosis (GO:0045836)2.58528799
79rRNA catabolic process (GO:0016075)2.58173584
80gamma-aminobutyric acid transport (GO:0015812)2.56503619
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.56411601
82hindbrain development (GO:0030902)2.54140520
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53340374
84positive regulation of prostaglandin secretion (GO:0032308)2.52377151
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51239371
86respiratory chain complex IV assembly (GO:0008535)2.51145353
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50531045
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49767030
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49064135
90negative regulation of telomere maintenance (GO:0032205)2.47838905
91protein K11-linked deubiquitination (GO:0035871)2.47681809
92ketone body metabolic process (GO:1902224)2.47375427
93synaptonemal complex organization (GO:0070193)2.47226597
94female gamete generation (GO:0007292)2.46811579
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46259140
96synaptonemal complex assembly (GO:0007130)2.45382287
97regulation of action potential (GO:0098900)2.41135654
98auditory receptor cell stereocilium organization (GO:0060088)2.40791320
99water-soluble vitamin biosynthetic process (GO:0042364)2.40508733
100startle response (GO:0001964)2.39550945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66274542
2ZNF274_21170338_ChIP-Seq_K562_Hela4.01984365
3GBX2_23144817_ChIP-Seq_PC3_Human2.90291615
4VDR_22108803_ChIP-Seq_LS180_Human2.78358158
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70313209
6IGF1R_20145208_ChIP-Seq_DFB_Human2.45555188
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18295500
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15372409
9EWS_26573619_Chip-Seq_HEK293_Human2.15033212
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.12972437
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.10624812
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08666661
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.06917968
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99991621
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99625123
16TAF15_26573619_Chip-Seq_HEK293_Human1.93266030
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90369118
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89087775
19ER_23166858_ChIP-Seq_MCF-7_Human1.83208912
20MYC_18940864_ChIP-ChIP_HL60_Human1.80127242
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77851324
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76915112
23P300_19829295_ChIP-Seq_ESCs_Human1.76387112
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74531379
25CBP_20019798_ChIP-Seq_JUKART_Human1.74531379
26FUS_26573619_Chip-Seq_HEK293_Human1.72913878
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.71738013
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.71216084
29TP53_22573176_ChIP-Seq_HFKS_Human1.70752145
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70671941
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67217138
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67063635
33IRF1_19129219_ChIP-ChIP_H3396_Human1.66649629
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61244401
35VDR_23849224_ChIP-Seq_CD4+_Human1.52826839
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52522808
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.52522808
38RNF2_27304074_Chip-Seq_NSC_Mouse1.50466803
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44909752
40BCAT_22108803_ChIP-Seq_LS180_Human1.44545009
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41247680
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41090085
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41076679
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40547759
45AR_25329375_ChIP-Seq_VCAP_Human1.39863590
46AR_20517297_ChIP-Seq_VCAP_Human1.35833353
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34248303
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.33178305
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32948719
50NANOG_19829295_ChIP-Seq_ESCs_Human1.32008700
51SOX2_19829295_ChIP-Seq_ESCs_Human1.32008700
52TCF4_23295773_ChIP-Seq_U87_Human1.31361902
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28117877
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26459272
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25200946
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25200946
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.24852466
58TCF4_22108803_ChIP-Seq_LS180_Human1.24329141
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23710518
60RUNX2_22187159_ChIP-Seq_PCA_Human1.23298985
61REST_21632747_ChIP-Seq_MESCs_Mouse1.22644446
62SMAD4_21799915_ChIP-Seq_A2780_Human1.21812556
63NCOR_22424771_ChIP-Seq_293T_Human1.21001717
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19934511
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18910396
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18824208
67STAT3_23295773_ChIP-Seq_U87_Human1.18478209
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17820597
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.17406743
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16298496
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.14212844
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13530571
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.13491314
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13260646
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12986335
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12618322
77AR_21572438_ChIP-Seq_LNCaP_Human1.11118796
78NANOG_20526341_ChIP-Seq_ESCs_Human1.10570685
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.09995837
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09797491
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.08667855
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.07460498
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.07338051
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.04084954
85HOXB7_26014856_ChIP-Seq_BT474_Human1.02790935
86MYC_19829295_ChIP-Seq_ESCs_Human1.01321108
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01160030
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01123808
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98288899
90TAF2_19829295_ChIP-Seq_ESCs_Human0.98059386
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.97204383
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96410839
93GATA3_26560356_Chip-Seq_TH2_Human0.96217192
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95611842
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95484512
96CDX2_22108803_ChIP-Seq_LS180_Human0.94456066
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94405755
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94400354
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.92687672
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92492484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.07845756
2MP0002138_abnormal_hepatobiliary_system3.05616431
3MP0002653_abnormal_ependyma_morphology2.88137988
4MP0003718_maternal_effect2.86634519
5MP0001968_abnormal_touch/_nociception2.71788992
6MP0002736_abnormal_nociception_after2.26477254
7MP0000569_abnormal_digit_pigmentation2.23935001
8MP0005551_abnormal_eye_electrophysiolog2.20613507
9MP0006072_abnormal_retinal_apoptosis2.15053164
10MP0004142_abnormal_muscle_tone2.06800022
11MP0005646_abnormal_pituitary_gland2.06329999
12MP0006292_abnormal_olfactory_placode2.03660780
13MP0005645_abnormal_hypothalamus_physiol2.01403829
14MP0003136_yellow_coat_color1.89729587
15MP0003195_calcinosis1.89624203
16MP0005253_abnormal_eye_physiology1.86484054
17MP0002102_abnormal_ear_morphology1.86370953
18MP0002735_abnormal_chemical_nociception1.85145522
19MP0000372_irregular_coat_pigmentation1.81283881
20MP0008058_abnormal_DNA_repair1.74226966
21MP0009046_muscle_twitch1.74091689
22MP0002638_abnormal_pupillary_reflex1.68541251
23MP0005075_abnormal_melanosome_morpholog1.65623484
24MP0002272_abnormal_nervous_system1.65446153
25MP0000427_abnormal_hair_cycle1.63929953
26MP0005410_abnormal_fertilization1.62919015
27MP0008872_abnormal_physiological_respon1.60211509
28MP0001929_abnormal_gametogenesis1.60178044
29MP0001986_abnormal_taste_sensitivity1.59429266
30MP0008995_early_reproductive_senescence1.58889631
31MP0006276_abnormal_autonomic_nervous1.58736852
32MP0002210_abnormal_sex_determination1.55017792
33MP0009745_abnormal_behavioral_response1.52677089
34MP0004885_abnormal_endolymph1.49200313
35MP0003646_muscle_fatigue1.45692437
36MP0001501_abnormal_sleep_pattern1.44606036
37MP0002876_abnormal_thyroid_physiology1.40971514
38MP0003880_abnormal_central_pattern1.40773684
39MP0005174_abnormal_tail_pigmentation1.39807719
40MP0003011_delayed_dark_adaptation1.37972604
41MP0008875_abnormal_xenobiotic_pharmacok1.36578117
42MP0003787_abnormal_imprinting1.33109665
43MP0003252_abnormal_bile_duct1.32942860
44MP0001485_abnormal_pinna_reflex1.30967272
45MP0005084_abnormal_gallbladder_morpholo1.28263451
46MP0005389_reproductive_system_phenotype1.25167105
47MP0001486_abnormal_startle_reflex1.24630888
48MP0000631_abnormal_neuroendocrine_gland1.24276323
49MP0002067_abnormal_sensory_capabilities1.23229134
50MP0000653_abnormal_sex_gland1.22224536
51MP0005671_abnormal_response_to1.21930358
52MP0001984_abnormal_olfaction1.21814909
53MP0003698_abnormal_male_reproductive1.21702301
54MP0002751_abnormal_autonomic_nervous1.21665082
55MP0005085_abnormal_gallbladder_physiolo1.19341513
56MP0002733_abnormal_thermal_nociception1.16993836
57MP0001919_abnormal_reproductive_system1.16035987
58MP0001905_abnormal_dopamine_level1.14432837
59MP0008789_abnormal_olfactory_epithelium1.13500508
60MP0002572_abnormal_emotion/affect_behav1.11358656
61MP0001970_abnormal_pain_threshold1.08911253
62MP0001145_abnormal_male_reproductive1.07858689
63MP0002095_abnormal_skin_pigmentation1.06679910
64MP0002234_abnormal_pharynx_morphology1.06412770
65MP0004133_heterotaxia1.05909398
66MP0008057_abnormal_DNA_replication1.03885348
67MP0004742_abnormal_vestibular_system1.03400631
68MP0001529_abnormal_vocalization1.01902975
69MP0002160_abnormal_reproductive_system1.01477460
70MP0005377_hearing/vestibular/ear_phenot1.00802422
71MP0003878_abnormal_ear_physiology1.00802422
72MP0003890_abnormal_embryonic-extraembry1.00512975
73MP0003283_abnormal_digestive_organ0.99163190
74MP0002837_dystrophic_cardiac_calcinosis0.98716140
75MP0002064_seizures0.97354263
76MP0000383_abnormal_hair_follicle0.96704396
77MP0001324_abnormal_eye_pigmentation0.96269984
78MP0001764_abnormal_homeostasis0.95772644
79MP0003121_genomic_imprinting0.94935268
80MP0002557_abnormal_social/conspecific_i0.94882144
81MP0004147_increased_porphyrin_level0.94113565
82MP0001119_abnormal_female_reproductive0.92909676
83MP0002277_abnormal_respiratory_mucosa0.92581647
84MP0003786_premature_aging0.90147141
85MP0005195_abnormal_posterior_eye0.90068688
86MP0004043_abnormal_pH_regulation0.88749262
87MP0002928_abnormal_bile_duct0.88048164
88MP0003635_abnormal_synaptic_transmissio0.84341907
89MP0002734_abnormal_mechanical_nocicepti0.84193289
90MP0002063_abnormal_learning/memory/cond0.80205263
91MP0001963_abnormal_hearing_physiology0.79188150
92MP0002938_white_spotting0.76661701
93MP0002229_neurodegeneration0.76632956
94MP0002752_abnormal_somatic_nervous0.75210368
95MP0004924_abnormal_behavior0.74928690
96MP0005386_behavior/neurological_phenoty0.74928690
97MP0002161_abnormal_fertility/fecundity0.74486041
98MP0005395_other_phenotype0.73991331
99MP0003699_abnormal_female_reproductive0.73377803
100MP0005647_abnormal_sex_gland0.72564291

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.32084415
2Abnormality of midbrain morphology (HP:0002418)4.24046163
3Molar tooth sign on MRI (HP:0002419)4.24046163
4Congenital stationary night blindness (HP:0007642)3.80851838
5True hermaphroditism (HP:0010459)3.73312522
6Pancreatic fibrosis (HP:0100732)3.73168250
7Type II lissencephaly (HP:0007260)3.37181546
8Medial flaring of the eyebrow (HP:0010747)3.20056986
9Attenuation of retinal blood vessels (HP:0007843)3.19659834
10Nephronophthisis (HP:0000090)3.18631259
11Abolished electroretinogram (ERG) (HP:0000550)2.95215322
12Retinal dysplasia (HP:0007973)2.88739283
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79088279
14Abnormality of alanine metabolism (HP:0010916)2.79088279
15Hyperalaninemia (HP:0003348)2.79088279
163-Methylglutaconic aciduria (HP:0003535)2.78429096
17Abnormality of the renal medulla (HP:0100957)2.61666582
18Gait imbalance (HP:0002141)2.59581616
19Abnormality of the renal cortex (HP:0011035)2.58505817
20Acute necrotizing encephalopathy (HP:0006965)2.57428292
21Tubular atrophy (HP:0000092)2.55387476
22Congenital primary aphakia (HP:0007707)2.55114247
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51324298
24Mitochondrial inheritance (HP:0001427)2.49731143
25Increased CSF lactate (HP:0002490)2.47764573
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.46525588
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.42126729
28Cystic liver disease (HP:0006706)2.42108196
29Optic disc pallor (HP:0000543)2.41843628
30Abnormal rod and cone electroretinograms (HP:0008323)2.41553977
31Nephrogenic diabetes insipidus (HP:0009806)2.37958002
32Absent/shortened dynein arms (HP:0200106)2.32299622
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.32299622
34Congenital sensorineural hearing impairment (HP:0008527)2.29433665
35Decreased central vision (HP:0007663)2.29238378
36Amelogenesis imperfecta (HP:0000705)2.25023914
37Mesangial abnormality (HP:0001966)2.20951685
38Progressive macrocephaly (HP:0004481)2.20369915
39Progressive inability to walk (HP:0002505)2.20179275
40Abnormal mitochondria in muscle tissue (HP:0008316)2.17602001
41Ulnar claw (HP:0001178)2.17090262
42Hyperventilation (HP:0002883)2.16313893
43Short tibia (HP:0005736)2.15567536
44Inability to walk (HP:0002540)2.15509246
45Hepatocellular necrosis (HP:0001404)2.15129073
46Hepatic necrosis (HP:0002605)2.14126877
47Cerebellar dysplasia (HP:0007033)2.13895778
48Acute encephalopathy (HP:0006846)2.13635239
49Renal cortical cysts (HP:0000803)2.12689764
50Abnormal ciliary motility (HP:0012262)2.09001060
51Lissencephaly (HP:0001339)2.08972732
52Abnormal respiratory motile cilium morphology (HP:0005938)2.06547795
53Abnormal respiratory epithelium morphology (HP:0012253)2.06547795
54Constricted visual fields (HP:0001133)2.04995132
55Gaze-evoked nystagmus (HP:0000640)2.03792644
56Sclerocornea (HP:0000647)2.03758814
57Stomatitis (HP:0010280)2.03493548
58Azoospermia (HP:0000027)2.02763660
59Genital tract atresia (HP:0001827)2.02108569
60Optic nerve hypoplasia (HP:0000609)2.00772929
61Anencephaly (HP:0002323)1.99369453
62Anterior segment dysgenesis (HP:0007700)1.98893712
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98629422
64Chronic hepatic failure (HP:0100626)1.97345202
65Decreased circulating renin level (HP:0003351)1.96135273
66Increased serum lactate (HP:0002151)1.95449403
67Pachygyria (HP:0001302)1.94584095
68Patellar aplasia (HP:0006443)1.93605359
69Abnormality of the renal collecting system (HP:0004742)1.93542230
70Postaxial foot polydactyly (HP:0001830)1.93093531
71Hypoplasia of the fovea (HP:0007750)1.92017685
72Aplasia/Hypoplasia of the fovea (HP:0008060)1.92017685
73Concave nail (HP:0001598)1.91631119
74Congenital hepatic fibrosis (HP:0002612)1.91393155
75Hypothermia (HP:0002045)1.90647107
76Stomach cancer (HP:0012126)1.90398072
77Male pseudohermaphroditism (HP:0000037)1.90292400
78Pendular nystagmus (HP:0012043)1.87577350
79Prostate neoplasm (HP:0100787)1.86960590
80Abnormality of the labia minora (HP:0012880)1.86674165
81Broad-based gait (HP:0002136)1.86616378
82Bony spicule pigmentary retinopathy (HP:0007737)1.86053476
83Abnormal drinking behavior (HP:0030082)1.84793978
84Polydipsia (HP:0001959)1.84793978
85Median cleft lip (HP:0000161)1.84440751
86Focal motor seizures (HP:0011153)1.84424928
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.83782838
88Abnormality of dental color (HP:0011073)1.83108053
89Large for gestational age (HP:0001520)1.82999956
90Absent thumb (HP:0009777)1.82647615
91Severe combined immunodeficiency (HP:0004430)1.81870430
92Retinitis pigmentosa (HP:0000510)1.81760890
93Aplasia/Hypoplasia of the patella (HP:0006498)1.81280601
94Abnormality of the fovea (HP:0000493)1.81142405
95Limb dystonia (HP:0002451)1.80307150
96Vaginal atresia (HP:0000148)1.77676975
97Postaxial hand polydactyly (HP:0001162)1.77073784
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76342123
99Febrile seizures (HP:0002373)1.76194052
100Duplicated collecting system (HP:0000081)1.73977872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.97632443
2FRK3.60417842
3TAOK33.26889084
4MAP4K23.09517753
5ADRBK23.07759836
6GRK12.34476521
7ZAK2.29023644
8TGFBR12.19306834
9CASK2.16595632
10NUAK12.15370457
11CDK82.13769303
12TLK12.12937787
13PINK12.00937086
14MAPK131.90115341
15CDK191.79071232
16PNCK1.75527942
17MAP3K41.71987317
18WNK41.69799169
19WNK31.69439708
20INSRR1.68054861
21TXK1.56560044
22OXSR11.56091780
23BCKDK1.54344823
24VRK11.44959398
25ACVR1B1.37528964
26CAMKK21.34879757
27PBK1.25904368
28TRIM281.24343960
29KIT1.08495033
30DYRK21.08181392
31MKNK21.04576267
32MAP4K11.00823652
33STK390.97813228
34RPS6KA40.97687183
35CDK90.96572182
36TEC0.92492007
37MAPKAPK50.92233199
38MAPKAPK30.91801479
39DAPK20.91209472
40ADRBK10.90792194
41MARK30.89966820
42MUSK0.87817611
43TIE10.82215150
44FLT30.81814209
45PRKCE0.80291315
46TNIK0.78892978
47VRK20.78399206
48NTRK30.74425038
49PRKCG0.74216811
50CDK30.73641519
51MAPK150.73349194
52WEE10.73185532
53DYRK30.72098621
54CSNK1G10.72033842
55MAP2K70.71497214
56CSNK1G30.69566167
57BRSK20.69369530
58RPS6KA50.68103096
59PLK20.66503738
60CSF1R0.66235860
61MST40.64631221
62IRAK10.63616316
63CSNK1G20.62921873
64IKBKB0.61998236
65PKN10.60358761
66EPHA40.60295230
67SYK0.59469774
68PRKCQ0.58797983
69STK38L0.58161622
70STK160.57918559
71PIM10.57338182
72TNK20.57256854
73CDC70.56424706
74MAP3K90.51895269
75MARK10.51135311
76CAMK2A0.50920817
77KDR0.50704350
78PRKACA0.49278863
79MATK0.48587000
80PLK40.48539449
81NTRK20.44908487
82ATR0.42841251
83CSNK1A1L0.41108461
84NME10.40454058
85PAK30.39774644
86CAMK10.37437410
87CSNK1D0.36454781
88LYN0.36257686
89ERBB30.35535718
90LCK0.34722129
91BCR0.34628422
92AURKA0.34425398
93ITK0.33169522
94PIK3CA0.33027253
95CSNK1A10.32915537
96PRKG10.32353512
97PLK30.30516539
98ATM0.29646182
99TAF10.29134861
100PRKCI0.28406084

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.73002478
2Oxidative phosphorylation_Homo sapiens_hsa001902.66019530
3Phototransduction_Homo sapiens_hsa047442.62906244
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61379896
5RNA polymerase_Homo sapiens_hsa030202.49901447
6Nitrogen metabolism_Homo sapiens_hsa009102.29071137
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27754684
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20610472
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20036897
10Parkinsons disease_Homo sapiens_hsa050122.11642836
11Homologous recombination_Homo sapiens_hsa034402.05082142
12Linoleic acid metabolism_Homo sapiens_hsa005911.99887174
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96511697
14Butanoate metabolism_Homo sapiens_hsa006501.96011285
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90714743
16Protein export_Homo sapiens_hsa030601.82975494
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76826378
18Nicotine addiction_Homo sapiens_hsa050331.75424002
19RNA degradation_Homo sapiens_hsa030181.72137178
20Primary immunodeficiency_Homo sapiens_hsa053401.71024342
21Huntingtons disease_Homo sapiens_hsa050161.67741954
22Regulation of autophagy_Homo sapiens_hsa041401.67002549
23Ether lipid metabolism_Homo sapiens_hsa005651.64424751
24Fanconi anemia pathway_Homo sapiens_hsa034601.62458499
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.59617035
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.57631068
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45865533
28Tryptophan metabolism_Homo sapiens_hsa003801.43065492
29Caffeine metabolism_Homo sapiens_hsa002321.41910992
30Olfactory transduction_Homo sapiens_hsa047401.41526332
31Selenocompound metabolism_Homo sapiens_hsa004501.33395589
32Taste transduction_Homo sapiens_hsa047421.33197846
33Dorso-ventral axis formation_Homo sapiens_hsa043201.31617243
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26553810
35Cardiac muscle contraction_Homo sapiens_hsa042601.22170245
36Ribosome_Homo sapiens_hsa030101.20478236
37Sulfur relay system_Homo sapiens_hsa041221.20142475
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18394392
39Alzheimers disease_Homo sapiens_hsa050101.18253158
40Peroxisome_Homo sapiens_hsa041461.17055969
41Proteasome_Homo sapiens_hsa030501.16225360
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13024388
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11385072
44Morphine addiction_Homo sapiens_hsa050321.09188092
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06403141
46Asthma_Homo sapiens_hsa053101.04977957
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.04385843
48Ovarian steroidogenesis_Homo sapiens_hsa049131.02086047
49Propanoate metabolism_Homo sapiens_hsa006401.00779888
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97940489
51Sulfur metabolism_Homo sapiens_hsa009200.96692983
52Base excision repair_Homo sapiens_hsa034100.95717979
53Steroid biosynthesis_Homo sapiens_hsa001000.95426878
54Nucleotide excision repair_Homo sapiens_hsa034200.94434855
55Mismatch repair_Homo sapiens_hsa034300.94173904
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93114130
57Chemical carcinogenesis_Homo sapiens_hsa052040.92655155
58ABC transporters_Homo sapiens_hsa020100.90859456
59Arachidonic acid metabolism_Homo sapiens_hsa005900.90291888
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89692380
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85334522
62Purine metabolism_Homo sapiens_hsa002300.84858507
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82000184
64Fatty acid biosynthesis_Homo sapiens_hsa000610.77873655
65GABAergic synapse_Homo sapiens_hsa047270.76170698
66Pyrimidine metabolism_Homo sapiens_hsa002400.74743127
67Collecting duct acid secretion_Homo sapiens_hsa049660.73549081
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.70325214
69Retinol metabolism_Homo sapiens_hsa008300.69533476
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.67852459
71One carbon pool by folate_Homo sapiens_hsa006700.66957126
72Metabolic pathways_Homo sapiens_hsa011000.62813380
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60752752
74Serotonergic synapse_Homo sapiens_hsa047260.60375771
75Autoimmune thyroid disease_Homo sapiens_hsa053200.59103482
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57209916
77Allograft rejection_Homo sapiens_hsa053300.57057123
78Graft-versus-host disease_Homo sapiens_hsa053320.57039390
79Circadian rhythm_Homo sapiens_hsa047100.55841745
80Type I diabetes mellitus_Homo sapiens_hsa049400.53256015
81Circadian entrainment_Homo sapiens_hsa047130.52862511
82Hematopoietic cell lineage_Homo sapiens_hsa046400.51947821
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50041596
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48960769
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46949050
86Fat digestion and absorption_Homo sapiens_hsa049750.46505583
87Salivary secretion_Homo sapiens_hsa049700.43415887
88Fatty acid metabolism_Homo sapiens_hsa012120.41823114
89Rheumatoid arthritis_Homo sapiens_hsa053230.41535942
90DNA replication_Homo sapiens_hsa030300.41535841
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40583160
92Glutamatergic synapse_Homo sapiens_hsa047240.39934447
93Insulin secretion_Homo sapiens_hsa049110.39413820
94RNA transport_Homo sapiens_hsa030130.38842322
95Calcium signaling pathway_Homo sapiens_hsa040200.35698562
96Glycerolipid metabolism_Homo sapiens_hsa005610.35553175
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35232432
98Fatty acid degradation_Homo sapiens_hsa000710.35186624
99Oocyte meiosis_Homo sapiens_hsa041140.33498458
100Fatty acid elongation_Homo sapiens_hsa000620.28509168

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