IRGQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59260225
2behavioral response to nicotine (GO:0035095)5.54149394
3synaptic vesicle maturation (GO:0016188)5.51662749
4locomotory exploration behavior (GO:0035641)5.28819352
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20724773
6layer formation in cerebral cortex (GO:0021819)5.01329549
7vocalization behavior (GO:0071625)4.67948490
8glutamate secretion (GO:0014047)4.65635327
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59998272
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.54114317
11synaptic vesicle exocytosis (GO:0016079)4.52237233
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49735678
13regulation of synaptic vesicle exocytosis (GO:2000300)4.45335403
14regulation of glutamate receptor signaling pathway (GO:1900449)4.24899427
15exploration behavior (GO:0035640)4.22935683
16proline transport (GO:0015824)4.11671021
17dendritic spine morphogenesis (GO:0060997)4.07851088
18neuron cell-cell adhesion (GO:0007158)4.04130833
19protein localization to synapse (GO:0035418)4.03892761
20regulation of synapse structural plasticity (GO:0051823)3.97361961
21dendrite morphogenesis (GO:0048813)3.94253276
22pyrimidine nucleobase catabolic process (GO:0006208)3.93343809
23neurotransmitter secretion (GO:0007269)3.91721604
24regulation of synaptic vesicle transport (GO:1902803)3.90743097
25cell migration in hindbrain (GO:0021535)3.84353619
26regulation of neuronal synaptic plasticity (GO:0048168)3.74709481
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65960051
28activation of protein kinase A activity (GO:0034199)3.63525713
29presynaptic membrane assembly (GO:0097105)3.52290427
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.51837781
31neuron recognition (GO:0008038)3.51721475
32positive regulation of synapse maturation (GO:0090129)3.51547436
33axonal fasciculation (GO:0007413)3.50847117
34presynaptic membrane organization (GO:0097090)3.47878962
35gamma-aminobutyric acid transport (GO:0015812)3.41627849
36nucleobase catabolic process (GO:0046113)3.36665296
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35081674
38sodium ion export (GO:0071436)3.32435251
39cell communication by electrical coupling (GO:0010644)3.31187537
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30215674
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27527323
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.27527323
43regulation of translation, ncRNA-mediated (GO:0045974)3.27527323
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27122101
45startle response (GO:0001964)3.24764255
46L-fucose catabolic process (GO:0042355)3.24726797
47fucose catabolic process (GO:0019317)3.24726797
48L-fucose metabolic process (GO:0042354)3.24726797
49transmission of nerve impulse (GO:0019226)3.22644915
50cellular potassium ion homeostasis (GO:0030007)3.19871323
51cerebellar Purkinje cell differentiation (GO:0021702)3.19293326
52neuromuscular process controlling balance (GO:0050885)3.19118018
53regulation of ARF protein signal transduction (GO:0032012)3.17587089
54neurotransmitter-gated ion channel clustering (GO:0072578)3.16387717
55mechanosensory behavior (GO:0007638)3.13264937
56neuronal action potential propagation (GO:0019227)3.11697489
57cerebellar Purkinje cell layer development (GO:0021680)3.08413117
58synaptic transmission, glutamatergic (GO:0035249)3.07281353
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06691860
60neuronal action potential (GO:0019228)3.05301920
61tryptophan catabolic process (GO:0006569)3.05105387
62indole-containing compound catabolic process (GO:0042436)3.05105387
63indolalkylamine catabolic process (GO:0046218)3.05105387
64limb bud formation (GO:0060174)3.05001891
65kynurenine metabolic process (GO:0070189)3.01790746
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00775705
67central nervous system projection neuron axonogenesis (GO:0021952)3.00483825
68glutamate receptor signaling pathway (GO:0007215)3.00192876
69innervation (GO:0060384)2.99209583
70response to pheromone (GO:0019236)2.98594081
71neurotransmitter transport (GO:0006836)2.97634339
72retinal ganglion cell axon guidance (GO:0031290)2.97106102
73auditory behavior (GO:0031223)2.96115381
74regulation of action potential (GO:0098900)2.96078485
75synaptic transmission, cholinergic (GO:0007271)2.95437655
76long-term memory (GO:0007616)2.94738427
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93773183
78regulation of dendritic spine morphogenesis (GO:0061001)2.93759914
79vesicle transport along microtubule (GO:0047496)2.93624424
80regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92673645
81neuromuscular synaptic transmission (GO:0007274)2.92473626
82organelle transport along microtubule (GO:0072384)2.92470024
83positive regulation of membrane potential (GO:0045838)2.91354783
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90955712
85axon extension (GO:0048675)2.90206503
86clathrin coat assembly (GO:0048268)2.90120616
87protein polyglutamylation (GO:0018095)2.88924544
88postsynaptic membrane organization (GO:0001941)2.88691483
89synaptic vesicle endocytosis (GO:0048488)2.87909732
90regulation of respiratory system process (GO:0044065)2.87503738
91establishment of nucleus localization (GO:0040023)2.87363379
92establishment of mitochondrion localization (GO:0051654)2.86818366
93regulation of synaptic plasticity (GO:0048167)2.86814686
94regulation of neurotransmitter secretion (GO:0046928)2.84732572
95spinal cord development (GO:0021510)2.84239146
96neuron-neuron synaptic transmission (GO:0007270)2.83626096
97membrane depolarization during action potential (GO:0086010)2.83527663
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82725575
99nonmotile primary cilium assembly (GO:0035058)2.82410053
100regulation of postsynaptic membrane potential (GO:0060078)2.81660337
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81575160
102alanine transport (GO:0032328)2.81305037
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80969494
104cell communication involved in cardiac conduction (GO:0086065)2.80029429
105regulation of neurotransmitter levels (GO:0001505)2.80020461
106response to auditory stimulus (GO:0010996)2.79818920
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79519763
108positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.79337123
109dendritic spine organization (GO:0097061)2.78326303
110negative regulation of microtubule polymerization (GO:0031115)2.78141908
111atrial cardiac muscle cell action potential (GO:0086014)2.77852103
112axon cargo transport (GO:0008088)2.77433881
113glycine transport (GO:0015816)2.77303125
114central nervous system neuron axonogenesis (GO:0021955)2.76308351
115positive regulation of fibroblast migration (GO:0010763)2.76224670
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71969664
117behavioral response to ethanol (GO:0048149)2.71742949
118cornea development in camera-type eye (GO:0061303)2.70789038
119prepulse inhibition (GO:0060134)2.70321764
120synapse assembly (GO:0007416)2.70131195
121neuron maturation (GO:0042551)2.69304266
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68678800
123positive regulation of axon extension (GO:0045773)2.67965432
124social behavior (GO:0035176)2.67774690
125intraspecies interaction between organisms (GO:0051703)2.67774690
126synapse organization (GO:0050808)2.66742999
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64247368
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63476699
129neuromuscular process (GO:0050905)2.62163744
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.61527784
131positive regulation of synapse assembly (GO:0051965)2.61392644
132mitochondrion transport along microtubule (GO:0047497)2.61045838
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61045838
134regulation of clathrin-mediated endocytosis (GO:2000369)2.60911040
135negative regulation of mast cell activation (GO:0033004)2.60114306
136positive regulation of potassium ion transmembrane transport (GO:1901381)2.59471017
137neuron projection extension (GO:1990138)2.59335226
138cerebellum development (GO:0021549)2.59066100
139cellular sodium ion homeostasis (GO:0006883)2.58394351
140indolalkylamine metabolic process (GO:0006586)2.57909227
141neural tube formation (GO:0001841)2.57354895
142action potential (GO:0001508)2.55915210
143regulation of axon guidance (GO:1902667)2.55557313
144adult walking behavior (GO:0007628)2.55544420
145protein localization to cilium (GO:0061512)2.54623969
146regulation of respiratory gaseous exchange (GO:0043576)2.52714012
147sympathetic nervous system development (GO:0048485)2.51108602
148negative regulation of axon guidance (GO:1902668)2.51046174
149regulation of hippo signaling (GO:0035330)2.48787561
150regulation of telomere maintenance (GO:0032204)2.48650851
151detection of light stimulus involved in sensory perception (GO:0050962)2.46671809
152detection of light stimulus involved in visual perception (GO:0050908)2.46671809
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46077642
154neurofilament cytoskeleton organization (GO:0060052)2.44890628
155positive regulation of sodium ion transmembrane transport (GO:1902307)2.44213843
156ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.43903016
157reflex (GO:0060004)2.43593445
158regulation of axon extension involved in axon guidance (GO:0048841)2.43500964
159serotonin metabolic process (GO:0042428)2.42859776
160glycerophospholipid catabolic process (GO:0046475)2.41457326
161glycosphingolipid biosynthetic process (GO:0006688)2.41117102
162regulation of membrane repolarization (GO:0060306)2.40595648
163primary amino compound metabolic process (GO:1901160)2.40301261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28441071
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74606508
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74173119
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70552600
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58030235
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58030235
7DROSHA_22980978_ChIP-Seq_HELA_Human2.51450536
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49592574
9GBX2_23144817_ChIP-Seq_PC3_Human2.49199130
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42563587
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.38467240
12REST_21632747_ChIP-Seq_MESCs_Mouse2.37558928
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35702343
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35540862
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.32959818
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31111578
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26260131
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24065377
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23249651
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16803743
21VDR_22108803_ChIP-Seq_LS180_Human2.15022383
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13636944
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12816868
24IGF1R_20145208_ChIP-Seq_DFB_Human2.11970911
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01969558
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01742840
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01529387
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01198433
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.96791039
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96284904
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93659094
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.91642142
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89156210
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85978720
35AR_21572438_ChIP-Seq_LNCaP_Human1.76173257
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74934275
37FUS_26573619_Chip-Seq_HEK293_Human1.65296613
38KDM2B_26808549_Chip-Seq_K562_Human1.64060922
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.62973655
40RNF2_27304074_Chip-Seq_NSC_Mouse1.61570758
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59662301
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57903667
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57903667
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55892561
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53933043
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.52840870
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49426329
48ER_23166858_ChIP-Seq_MCF-7_Human1.49008272
49EWS_26573619_Chip-Seq_HEK293_Human1.47145233
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.44391907
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42142424
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42069635
53ZNF274_21170338_ChIP-Seq_K562_Hela1.41790705
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.40056648
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38060088
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36825214
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36570937
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33675901
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33411842
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32344796
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32095849
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30942001
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30650612
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30465487
65SMAD4_21799915_ChIP-Seq_A2780_Human1.29985906
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29662402
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29511211
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.28900763
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27856425
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.26445475
71AR_19668381_ChIP-Seq_PC3_Human1.25437669
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25415948
73AHR_22903824_ChIP-Seq_MCF-7_Human1.24062408
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22836447
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21985584
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21788801
77CBP_20019798_ChIP-Seq_JUKART_Human1.21683746
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21683746
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21149588
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20783094
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20687208
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.18193443
83BCAT_22108803_ChIP-Seq_LS180_Human1.17415037
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16889975
85RUNX2_22187159_ChIP-Seq_PCA_Human1.16729987
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16480868
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16311381
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13676690
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13067769
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12823070
91TP53_16413492_ChIP-PET_HCT116_Human1.11318330
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10266470
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07925534
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07712294
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07582367
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.06895135
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06322898
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06268577
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05870632
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04612207
101TP53_22573176_ChIP-Seq_HFKS_Human1.04538381
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04092505
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03669779
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03459391
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02800298
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.01953752
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01924409
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01411726
109STAT3_23295773_ChIP-Seq_U87_Human1.01143910
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00576342
111AR_25329375_ChIP-Seq_VCAP_Human1.00355693
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.00123910
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.99788197
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.99215597
115TCF4_22108803_ChIP-Seq_LS180_Human0.98044314
116PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97964444
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.97291311
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.97013254
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.96984071
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96893240
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96558216
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.95896304
123* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94152982
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94122023
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.93946472
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.93283755
127* CTCF_27219007_Chip-Seq_Bcells_Human0.92511231
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.92453700
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92280721
130KDM2B_26808549_Chip-Seq_DND41_Human0.92119708
131TAF15_26573619_Chip-Seq_HEK293_Human0.91599392
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.91346382
133RXR_22108803_ChIP-Seq_LS180_Human0.91034620
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90699337
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.90309358
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.89989304
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89505891
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89487586
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88792207
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87931288
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86652021
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.85417318
143P300_19829295_ChIP-Seq_ESCs_Human0.84949624
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84640222
145TCF4_23295773_ChIP-Seq_U87_Human0.84619473
146* LXR_22292898_ChIP-Seq_THP-1_Human0.83622047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30557724
2MP0004270_analgesia4.00515475
3MP0003635_abnormal_synaptic_transmissio3.80507546
4MP0003880_abnormal_central_pattern3.77066821
5MP0002063_abnormal_learning/memory/cond3.02510209
6MP0005423_abnormal_somatic_nervous2.94497434
7MP0009780_abnormal_chondrocyte_physiolo2.90820863
8MP0009745_abnormal_behavioral_response2.69652201
9MP0002734_abnormal_mechanical_nocicepti2.66044673
10MP0001968_abnormal_touch/_nociception2.64210723
11MP0002064_seizures2.50913553
12MP0004858_abnormal_nervous_system2.41930716
13MP0009046_muscle_twitch2.36403213
14MP0002909_abnormal_adrenal_gland2.35498602
15MP0002572_abnormal_emotion/affect_behav2.31853975
16MP0002735_abnormal_chemical_nociception2.31019173
17MP0000778_abnormal_nervous_system2.29473124
18MP0000569_abnormal_digit_pigmentation2.21085776
19MP0002733_abnormal_thermal_nociception2.18122388
20MP0002184_abnormal_innervation2.06459652
21MP0001486_abnormal_startle_reflex2.04697300
22MP0006276_abnormal_autonomic_nervous2.01465184
23MP0004811_abnormal_neuron_physiology2.00018116
24MP0004142_abnormal_muscle_tone1.90577427
25MP0004133_heterotaxia1.89708768
26MP0008877_abnormal_DNA_methylation1.87537375
27MP0002272_abnormal_nervous_system1.87204028
28MP0003329_amyloid_beta_deposits1.87139426
29MP0001970_abnormal_pain_threshold1.85779162
30MP0002822_catalepsy1.83264529
31MP0002736_abnormal_nociception_after1.78236158
32MP0001440_abnormal_grooming_behavior1.75186714
33MP0005551_abnormal_eye_electrophysiolog1.74373891
34MP0002653_abnormal_ependyma_morphology1.73613161
35MP0000955_abnormal_spinal_cord1.73123548
36MP0002557_abnormal_social/conspecific_i1.71479852
37MP0001529_abnormal_vocalization1.70330061
38MP0001501_abnormal_sleep_pattern1.66325299
39MP0002638_abnormal_pupillary_reflex1.64433803
40MP0005645_abnormal_hypothalamus_physiol1.62939018
41MP0002067_abnormal_sensory_capabilities1.62475816
42MP0003195_calcinosis1.58805469
43MP0008569_lethality_at_weaning1.58804890
44MP0002102_abnormal_ear_morphology1.57251116
45MP0004924_abnormal_behavior1.55698831
46MP0005386_behavior/neurological_phenoty1.55698831
47MP0004742_abnormal_vestibular_system1.53095678
48MP0008961_abnormal_basal_metabolism1.50741007
49MP0004043_abnormal_pH_regulation1.48575337
50MP0004885_abnormal_endolymph1.46712949
51MP0003646_muscle_fatigue1.45054940
52MP0001984_abnormal_olfaction1.44361250
53MP0003890_abnormal_embryonic-extraembry1.44161162
54MP0003879_abnormal_hair_cell1.43572366
55MP0002882_abnormal_neuron_morphology1.41691245
56MP0001188_hyperpigmentation1.38032802
57MP0001986_abnormal_taste_sensitivity1.37977141
58MP0001485_abnormal_pinna_reflex1.37207630
59MP0003121_genomic_imprinting1.35817554
60MP0003122_maternal_imprinting1.34515876
61MP0002751_abnormal_autonomic_nervous1.29495501
62MP0005646_abnormal_pituitary_gland1.29057423
63MP0002066_abnormal_motor_capabilities/c1.28175586
64MP0010234_abnormal_vibrissa_follicle1.27688061
65MP0003136_yellow_coat_color1.27440944
66MP0002876_abnormal_thyroid_physiology1.26927317
67MP0003283_abnormal_digestive_organ1.24318878
68MP0005187_abnormal_penis_morphology1.23962987
69MP0000751_myopathy1.23595941
70MP0002152_abnormal_brain_morphology1.19037890
71MP0000013_abnormal_adipose_tissue1.15749246
72MP0003633_abnormal_nervous_system1.11898629
73MP0005253_abnormal_eye_physiology1.11247646
74MP0002837_dystrophic_cardiac_calcinosis1.11217456
75MP0000427_abnormal_hair_cycle1.11114477
76MP0005174_abnormal_tail_pigmentation1.08833046
77MP0008872_abnormal_physiological_respon1.06316636
78MP0001299_abnormal_eye_distance/1.06295355
79MP0004130_abnormal_muscle_cell1.06085651
80MP0006292_abnormal_olfactory_placode1.05654242
81MP0008875_abnormal_xenobiotic_pharmacok1.03120935
82MP0006072_abnormal_retinal_apoptosis1.01657960
83MP0001502_abnormal_circadian_rhythm1.00968913
84MP0001348_abnormal_lacrimal_gland0.99679494
85MP0002234_abnormal_pharynx_morphology0.98596802
86MP0005195_abnormal_posterior_eye0.97657848
87MP0002069_abnormal_eating/drinking_beha0.97313709
88MP0002938_white_spotting0.96371904
89MP0005499_abnormal_olfactory_system0.95086547
90MP0005394_taste/olfaction_phenotype0.95086547
91MP0010386_abnormal_urinary_bladder0.94852843
92MP0003787_abnormal_imprinting0.92811600
93MP0004085_abnormal_heartbeat0.91875440
94MP0005623_abnormal_meninges_morphology0.90984782
95MP0002928_abnormal_bile_duct0.89725937
96MP0000026_abnormal_inner_ear0.88239507
97MP0003631_nervous_system_phenotype0.87725973
98MP0000537_abnormal_urethra_morphology0.87587626
99MP0004233_abnormal_muscle_weight0.85774673
100MP0003634_abnormal_glial_cell0.85399496
101MP0000604_amyloidosis0.83826584
102MP0001177_atelectasis0.82197191
103MP0004145_abnormal_muscle_electrophysio0.82023709
104MP0003011_delayed_dark_adaptation0.81807584
105MP0003861_abnormal_nervous_system0.81588536
106MP0008995_early_reproductive_senescence0.81448173
107MP0001963_abnormal_hearing_physiology0.81178914
108MP0000647_abnormal_sebaceous_gland0.78173057
109MP0003172_abnormal_lysosome_physiology0.76546742
110MP0005535_abnormal_body_temperature0.76040274
111MP0000631_abnormal_neuroendocrine_gland0.75865645
112MP0003137_abnormal_impulse_conducting0.74841504
113MP0000003_abnormal_adipose_tissue0.73465851
114MP0005448_abnormal_energy_balance0.72330480
115MP0003937_abnormal_limbs/digits/tail_de0.72228649
116MP0000383_abnormal_hair_follicle0.72185793
117MP0008874_decreased_physiological_sensi0.71675265
118MP0000534_abnormal_ureter_morphology0.67068145
119MP0002229_neurodegeneration0.66697446
120MP0004215_abnormal_myocardial_fiber0.64711054
121MP0004484_altered_response_of0.64465115
122MP0002752_abnormal_somatic_nervous0.63346167
123MP0004510_myositis0.63163017
124MP0002089_abnormal_postnatal_growth/wei0.62096545
125MP0000747_muscle_weakness0.61296531
126MP0003303_peritoneal_inflammation0.61274568
127MP0010769_abnormal_survival0.58808285
128MP0003183_abnormal_peptide_metabolism0.58187019
129MP0005248_abnormal_Harderian_gland0.57749192
130MP0002082_postnatal_lethality0.57080023
131MP0010770_preweaning_lethality0.57080023
132MP0002896_abnormal_bone_mineralization0.56322559
133MP0001943_abnormal_respiration0.55988038
134MP0001905_abnormal_dopamine_level0.55904488
135MP0003632_abnormal_nervous_system0.55700094
136MP0003119_abnormal_digestive_system0.54021346
137MP0002090_abnormal_vision0.53606762
138MP0010768_mortality/aging0.53047436

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.20767227
2Focal motor seizures (HP:0011153)4.62503307
3Focal seizures (HP:0007359)4.44768883
4Visual hallucinations (HP:0002367)4.26991235
5Supranuclear gaze palsy (HP:0000605)3.92779359
6Pancreatic cysts (HP:0001737)3.71919461
7Abnormality of midbrain morphology (HP:0002418)3.55063338
8Molar tooth sign on MRI (HP:0002419)3.55063338
9Action tremor (HP:0002345)3.49489300
10Ankle clonus (HP:0011448)3.34048805
11Nephronophthisis (HP:0000090)3.31596056
12Progressive cerebellar ataxia (HP:0002073)3.29655898
13Epileptic encephalopathy (HP:0200134)3.23641722
14Protruding tongue (HP:0010808)3.22106454
15Inability to walk (HP:0002540)3.20841346
16Type II lissencephaly (HP:0007260)3.17808692
17Papilledema (HP:0001085)3.14068677
18Lissencephaly (HP:0001339)3.13142688
19Mutism (HP:0002300)3.11076393
20True hermaphroditism (HP:0010459)3.07371795
21Atonic seizures (HP:0010819)3.02001093
22Congenital stationary night blindness (HP:0007642)3.01463247
23Poor eye contact (HP:0000817)2.94488980
24Pancreatic fibrosis (HP:0100732)2.93733631
25Genetic anticipation (HP:0003743)2.90888910
26Absence seizures (HP:0002121)2.85918248
27Abnormal social behavior (HP:0012433)2.85514672
28Impaired social interactions (HP:0000735)2.85514672
29Chronic hepatic failure (HP:0100626)2.82382364
30Urinary bladder sphincter dysfunction (HP:0002839)2.82278372
31Abnormality of the renal medulla (HP:0100957)2.80520151
32Generalized tonic-clonic seizures (HP:0002069)2.78998406
33Depression (HP:0000716)2.78854745
34Termporal pattern (HP:0011008)2.77337185
35Insidious onset (HP:0003587)2.77337185
36Febrile seizures (HP:0002373)2.76511963
37Megalencephaly (HP:0001355)2.75998063
38Drooling (HP:0002307)2.73289622
39Excessive salivation (HP:0003781)2.73289622
40Medial flaring of the eyebrow (HP:0010747)2.68906423
41Insomnia (HP:0100785)2.67048820
42Gait imbalance (HP:0002141)2.66299299
43Abnormality of the lower motor neuron (HP:0002366)2.61795432
44Torticollis (HP:0000473)2.60936835
45Elfin facies (HP:0004428)2.60936245
46Urinary urgency (HP:0000012)2.57070440
47Dialeptic seizures (HP:0011146)2.55770015
48Truncal ataxia (HP:0002078)2.54990498
49Ventricular fibrillation (HP:0001663)2.54707683
50Impaired vibration sensation in the lower limbs (HP:0002166)2.53861658
51Tubular atrophy (HP:0000092)2.53721782
52Abnormal eating behavior (HP:0100738)2.52614153
53Cerebral inclusion bodies (HP:0100314)2.51009919
54Broad-based gait (HP:0002136)2.49864185
55Agitation (HP:0000713)2.47789285
56Hyperacusis (HP:0010780)2.46368001
57Postural instability (HP:0002172)2.45775290
58Absent speech (HP:0001344)2.44350349
59Abnormality of the labia minora (HP:0012880)2.44331988
60Bundle branch block (HP:0011710)2.42119785
61Limb dystonia (HP:0002451)2.36503840
62Amblyopia (HP:0000646)2.36435999
63Focal dystonia (HP:0004373)2.32500561
64Abnormality of the renal cortex (HP:0011035)2.31030181
65EEG with generalized epileptiform discharges (HP:0011198)2.30999719
66Dysdiadochokinesis (HP:0002075)2.30920169
67Macroorchidism (HP:0000053)2.30418179
68Hypsarrhythmia (HP:0002521)2.28282713
69Epileptiform EEG discharges (HP:0011182)2.27574832
70Amyotrophic lateral sclerosis (HP:0007354)2.26569078
71Neurofibrillary tangles (HP:0002185)2.25008710
72Anxiety (HP:0000739)2.24626826
73Abnormality of the corticospinal tract (HP:0002492)2.24014520
74Large for gestational age (HP:0001520)2.23203256
75Cerebellar dysplasia (HP:0007033)2.20296801
76Stereotypic behavior (HP:0000733)2.18268043
77Cystic liver disease (HP:0006706)2.17920919
78Pointed chin (HP:0000307)2.17473718
79Prolonged QT interval (HP:0001657)2.17358311
80Congenital primary aphakia (HP:0007707)2.16876774
81Akinesia (HP:0002304)2.16858367
82Pheochromocytoma (HP:0002666)2.16009401
83Attenuation of retinal blood vessels (HP:0007843)2.15353452
84Impaired smooth pursuit (HP:0007772)2.15339957
85Spastic gait (HP:0002064)2.14343882
86Hemiplegia (HP:0002301)2.14157835
87Patellar aplasia (HP:0006443)2.13602403
88Polyphagia (HP:0002591)2.12257380
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12102622
90Abnormality of alanine metabolism (HP:0010916)2.12102622
91Hyperalaninemia (HP:0003348)2.12102622
92Craniofacial dystonia (HP:0012179)2.11153144
93Failure to thrive in infancy (HP:0001531)2.10668960
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10128556
95Dysmetric saccades (HP:0000641)2.10065373
96Dysmetria (HP:0001310)2.08950867
97Obstructive sleep apnea (HP:0002870)2.08390861
98Hemiparesis (HP:0001269)2.08280076
99Fetal akinesia sequence (HP:0001989)2.07449643
100Lower limb muscle weakness (HP:0007340)2.07317750
101Sclerocornea (HP:0000647)2.06821706
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05574935
103Nephrogenic diabetes insipidus (HP:0009806)2.05558686
104Genital tract atresia (HP:0001827)2.04149001
105Lower limb amyotrophy (HP:0007210)2.03916658
106Vaginal atresia (HP:0000148)2.03211391
107Chorioretinal atrophy (HP:0000533)2.01457530
108Abnormal drinking behavior (HP:0030082)2.00835011
109Polydipsia (HP:0001959)2.00835011
110Apathy (HP:0000741)2.00415328
111Bradykinesia (HP:0002067)1.99464540
112Progressive inability to walk (HP:0002505)1.98174657
113Clumsiness (HP:0002312)1.97733896
114Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97079460
115Hypoplasia of the brainstem (HP:0002365)1.97079460
116Pendular nystagmus (HP:0012043)1.96700832
117Inappropriate behavior (HP:0000719)1.95642880
118Hepatoblastoma (HP:0002884)1.95619229
119Neoplasm of the heart (HP:0100544)1.95043934
120Aplasia/Hypoplasia of the patella (HP:0006498)1.94840302
121Anencephaly (HP:0002323)1.93640182
122Hyperventilation (HP:0002883)1.93546225
123Concave nail (HP:0001598)1.93421921
124Gaze-evoked nystagmus (HP:0000640)1.93127085
125Retinal dysplasia (HP:0007973)1.92120415
126Polymicrogyria (HP:0002126)1.91261039
127Aqueductal stenosis (HP:0002410)1.89717177
128Partial agenesis of the corpus callosum (HP:0001338)1.87003486
129Macroglossia (HP:0000158)1.86278381
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84946161
131Severe muscular hypotonia (HP:0006829)1.84574096
132Hypoventilation (HP:0002791)1.84378673
133Open mouth (HP:0000194)1.83134603
134Overriding aorta (HP:0002623)1.83045564
135Abnormality of salivation (HP:0100755)1.82890560
136Abnormality of the pons (HP:0007361)1.82420051
137Intention tremor (HP:0002080)1.82113299
138Fair hair (HP:0002286)1.81626443
139Neuroendocrine neoplasm (HP:0100634)1.81149633
140Widely spaced teeth (HP:0000687)1.81026719
141Hypercortisolism (HP:0001578)1.80851466
142Renovascular hypertension (HP:0100817)1.80532516
143Exotropia (HP:0000577)1.79806737
144Status epilepticus (HP:0002133)1.79037609
145Diminished motivation (HP:0000745)1.78983802
146Narrow forehead (HP:0000341)1.78851394
147Hypoplasia of the pons (HP:0012110)1.78714966
148Sacral dimple (HP:0000960)1.78395761
149Abnormality of ocular smooth pursuit (HP:0000617)1.77625693
150Poor coordination (HP:0002370)1.77489952
151Pachygyria (HP:0001302)1.76757687
152Rapidly progressive (HP:0003678)1.76699332
153Intellectual disability, profound (HP:0002187)1.76675713
154Ankyloglossia (HP:0010296)1.74529384
155Morphological abnormality of the pyramidal tract (HP:0002062)1.73956209
156Specific learning disability (HP:0001328)1.73906269
157Abolished electroretinogram (ERG) (HP:0000550)1.73107214
158Spastic tetraplegia (HP:0002510)1.72481496
159Oligodactyly (hands) (HP:0001180)1.71593835
160Polyuria (HP:0000103)1.71462786
161Keratoconus (HP:0000563)1.71436523
162Increased corneal curvature (HP:0100692)1.71436523
163Bony spicule pigmentary retinopathy (HP:0007737)1.70750097
164Ulnar claw (HP:0001178)1.70547635
165Optic nerve hypoplasia (HP:0000609)1.64278161
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.64173007
167Congenital sensorineural hearing impairment (HP:0008527)1.63054889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.05510365
2MAP3K94.14566886
3NTRK33.57883327
4MINK12.62751111
5MAP3K42.58183322
6PINK12.52415809
7EPHA42.46727941
8DAPK22.45499722
9ADRBK22.42555129
10PAK62.35795482
11TNIK2.19658590
12BMPR1B2.13610283
13NTRK22.08959815
14KSR21.98272787
15LATS21.93139853
16PRKD31.90912280
17NTRK11.88967913
18CAMKK11.86588990
19PHKG21.83369609
20PHKG11.83369609
21TLK11.80640057
22SIK21.79442247
23MAP2K71.78191622
24MAP2K41.75291860
25MKNK21.73091711
26ACVR1B1.70632590
27KSR11.68700342
28TRIM281.65549538
29MAP3K21.47786731
30ZAK1.46844103
31CDK51.45175247
32TRIB31.43705767
33INSRR1.38323586
34RIPK11.37894770
35GRK11.34958766
36MAP4K21.34744753
37MAPK131.31720332
38WNK41.30356023
39RET1.30173142
40BCR1.26328689
41TAOK11.25564224
42STK381.24494538
43TYRO31.20015414
44LMTK21.20011522
45PAK31.13868765
46UHMK11.11410705
47CAMK1G1.10590923
48MARK21.05019388
49DAPK11.04935368
50SGK30.98523103
51MAP3K120.97501413
52SGK2230.97245247
53SGK4940.97245247
54SCYL20.97000668
55GRK50.96072628
56ALK0.95451899
57PRKCH0.94600395
58AKT30.94294994
59CSNK1G20.94096365
60EPHA30.94049861
61STK110.92700567
62SGK20.92444763
63PRKCG0.92179579
64OXSR10.91783416
65CSNK1G10.91503416
66MAPK150.86800252
67PKN10.84166688
68FGFR20.82436177
69ADRBK10.80427887
70PLK20.80207048
71PDGFRA0.79985769
72PRKCE0.79939807
73ICK0.78488210
74PKN20.78045182
75RPS6KA20.77978806
76STK390.76730231
77EPHB20.76594506
78MAP3K70.76024996
79PRKCZ0.75082979
80CDK140.73870344
81DYRK20.73808693
82CDK180.72966464
83ERBB30.72913503
84CDK150.72522101
85WNK30.71143852
86TGFBR10.68831187
87CAMKK20.68741555
88CAMK10.67354949
89CHUK0.66501746
90NUAK10.65318098
91DMPK0.65179963
92FER0.62743576
93SGK10.61335304
94DYRK1A0.60007393
95CDK11A0.59848211
96CDC42BPA0.59387189
97PNCK0.59156125
98CAMK2A0.58952180
99FES0.58599262
100DYRK30.57508380
101TAOK30.57105923
102CSNK1D0.55668111
103MAP3K10.55606791
104CAMK1D0.53186966
105RIPK40.51644793
106PIK3CA0.51511703
107MAP2K10.51174381
108TIE10.50307616
109FYN0.49767612
110PDK10.48425370
111CSNK1A10.47971881
112PDPK10.47901911
113STK38L0.47405481
114CASK0.47310581
115DDR20.46902523
116RPS6KA30.46257637
117CSNK1A1L0.46136366
118PTK2B0.45967984
119MAP3K100.45567994
120NEK10.44306122
121MKNK10.43674159
122MAPK100.41982634
123FRK0.41820104
124PRKAA10.41787630
125ROCK10.41747352
126OBSCN0.41693983
127PRKACA0.41420097
128CAMK40.41403674
129MAPK120.40871220
130CDK190.40231149
131FGFR30.39421139
132MAPK80.38392438
133ERBB20.36742681
134PRPF4B0.36014109
135CSNK1G30.35364553
136PRKCI0.35273665
137HIPK20.35231593
138SIK10.34831129
139PRKG10.34383359
140DYRK1B0.33416053
141RPS6KA60.33111526
142CSNK1E0.32095589
143PRKACB0.31351207
144RPS6KA50.30131848
145GSK3B0.27917614

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.72497319
2Phototransduction_Homo sapiens_hsa047442.71822614
3Nicotine addiction_Homo sapiens_hsa050332.51379447
4Olfactory transduction_Homo sapiens_hsa047402.27048343
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26178508
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25832084
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24162507
8Circadian entrainment_Homo sapiens_hsa047132.15400760
9Long-term potentiation_Homo sapiens_hsa047202.13162332
10GABAergic synapse_Homo sapiens_hsa047272.09805461
11Glutamatergic synapse_Homo sapiens_hsa047241.96406432
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95479852
13Insulin secretion_Homo sapiens_hsa049111.90259386
14Dopaminergic synapse_Homo sapiens_hsa047281.88541204
15Morphine addiction_Homo sapiens_hsa050321.88005520
16Amphetamine addiction_Homo sapiens_hsa050311.86023152
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80956553
18Cholinergic synapse_Homo sapiens_hsa047251.78595874
19Caffeine metabolism_Homo sapiens_hsa002321.76344474
20Selenocompound metabolism_Homo sapiens_hsa004501.72615844
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71965025
22Salivary secretion_Homo sapiens_hsa049701.70618739
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69545006
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68297787
25Linoleic acid metabolism_Homo sapiens_hsa005911.64107150
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64099830
27Gastric acid secretion_Homo sapiens_hsa049711.62460053
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58403627
29Ether lipid metabolism_Homo sapiens_hsa005651.57189076
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56103028
31Type II diabetes mellitus_Homo sapiens_hsa049301.55376974
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55282805
33Cocaine addiction_Homo sapiens_hsa050301.45993651
34Oxytocin signaling pathway_Homo sapiens_hsa049211.45010549
35Glioma_Homo sapiens_hsa052141.41582644
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40743054
37Axon guidance_Homo sapiens_hsa043601.38688902
38Nitrogen metabolism_Homo sapiens_hsa009101.37048779
39Gap junction_Homo sapiens_hsa045401.36750221
40Renin secretion_Homo sapiens_hsa049241.36546700
41GnRH signaling pathway_Homo sapiens_hsa049121.33847111
42Taste transduction_Homo sapiens_hsa047421.32268409
43Estrogen signaling pathway_Homo sapiens_hsa049151.30826803
44Tryptophan metabolism_Homo sapiens_hsa003801.26623398
45Long-term depression_Homo sapiens_hsa047301.25848415
46ErbB signaling pathway_Homo sapiens_hsa040121.21074072
47Serotonergic synapse_Homo sapiens_hsa047261.18498494
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16861933
49Dorso-ventral axis formation_Homo sapiens_hsa043201.16535515
50Endometrial cancer_Homo sapiens_hsa052131.15804662
51Melanogenesis_Homo sapiens_hsa049161.15616743
52Oxidative phosphorylation_Homo sapiens_hsa001901.12865652
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10907076
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10827901
55Calcium signaling pathway_Homo sapiens_hsa040201.09019914
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08682583
57cAMP signaling pathway_Homo sapiens_hsa040241.07103446
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.99925293
59mTOR signaling pathway_Homo sapiens_hsa041500.99251982
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99242314
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98862727
62Ovarian steroidogenesis_Homo sapiens_hsa049130.97754468
63Steroid biosynthesis_Homo sapiens_hsa001000.96917234
64Basal transcription factors_Homo sapiens_hsa030220.94593210
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93715656
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89951441
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.89627963
68Dilated cardiomyopathy_Homo sapiens_hsa054140.89440222
69Insulin signaling pathway_Homo sapiens_hsa049100.88967579
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87158929
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.85436789
72Renal cell carcinoma_Homo sapiens_hsa052110.85064007
73VEGF signaling pathway_Homo sapiens_hsa043700.79868557
74Basal cell carcinoma_Homo sapiens_hsa052170.79825881
75Choline metabolism in cancer_Homo sapiens_hsa052310.78920859
76Glucagon signaling pathway_Homo sapiens_hsa049220.77958295
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77841099
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77484867
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.75691364
80Non-small cell lung cancer_Homo sapiens_hsa052230.75670542
81ABC transporters_Homo sapiens_hsa020100.75512645
82Parkinsons disease_Homo sapiens_hsa050120.75321515
83Thyroid hormone synthesis_Homo sapiens_hsa049180.74535891
84MAPK signaling pathway_Homo sapiens_hsa040100.72783322
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72771498
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71699515
87Bile secretion_Homo sapiens_hsa049760.71098306
88Colorectal cancer_Homo sapiens_hsa052100.70951852
89Pancreatic secretion_Homo sapiens_hsa049720.69528365
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67895683
91Oocyte meiosis_Homo sapiens_hsa041140.67111622
92Regulation of autophagy_Homo sapiens_hsa041400.66764451
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66711916
94Endocytosis_Homo sapiens_hsa041440.65263973
95Collecting duct acid secretion_Homo sapiens_hsa049660.63670612
96Alcoholism_Homo sapiens_hsa050340.62006182
97Lysine degradation_Homo sapiens_hsa003100.61622927
98Rap1 signaling pathway_Homo sapiens_hsa040150.60441774
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60285196
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59592089
101Prolactin signaling pathway_Homo sapiens_hsa049170.59185948
102Huntingtons disease_Homo sapiens_hsa050160.59182033
103Alzheimers disease_Homo sapiens_hsa050100.59163891
104Wnt signaling pathway_Homo sapiens_hsa043100.58542608
105Prion diseases_Homo sapiens_hsa050200.57629518
106Propanoate metabolism_Homo sapiens_hsa006400.57457098
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57342331
108Vibrio cholerae infection_Homo sapiens_hsa051100.57204744
109Ras signaling pathway_Homo sapiens_hsa040140.57013551
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57007283
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56887799
112Hedgehog signaling pathway_Homo sapiens_hsa043400.55937663
113Insulin resistance_Homo sapiens_hsa049310.54674452
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54361045
115AMPK signaling pathway_Homo sapiens_hsa041520.54285663
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52664759
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52361856
118Cardiac muscle contraction_Homo sapiens_hsa042600.51995486
119Glycerolipid metabolism_Homo sapiens_hsa005610.51547336
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.51335061
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.50819027
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49453795
123RNA polymerase_Homo sapiens_hsa030200.49319912
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49301231
125Peroxisome_Homo sapiens_hsa041460.49008481
126Butanoate metabolism_Homo sapiens_hsa006500.48420876
127Chronic myeloid leukemia_Homo sapiens_hsa052200.47769440
128Inositol phosphate metabolism_Homo sapiens_hsa005620.46869327
129beta-Alanine metabolism_Homo sapiens_hsa004100.46860884
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.46633284
131Hippo signaling pathway_Homo sapiens_hsa043900.45945251
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43219533
133Proteoglycans in cancer_Homo sapiens_hsa052050.43165578
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42362035
135Fatty acid biosynthesis_Homo sapiens_hsa000610.42343817
136Fanconi anemia pathway_Homo sapiens_hsa034600.42037388
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40944499
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40820443
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40761026
140Circadian rhythm_Homo sapiens_hsa047100.40380717
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39112218
142Sphingolipid metabolism_Homo sapiens_hsa006000.36012928
143Mineral absorption_Homo sapiens_hsa049780.34545188
144Protein export_Homo sapiens_hsa030600.33166476

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