IRS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.29909141
2desmosome organization (GO:0002934)4.77017705
3collagen fibril organization (GO:0030199)4.72544948
4cell-substrate junction assembly (GO:0007044)4.31813547
5protein heterotrimerization (GO:0070208)4.31129455
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.24932576
7dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.18696457
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.14943307
9axon extension involved in axon guidance (GO:0048846)4.14943307
10bone trabecula formation (GO:0060346)3.88101438
11* insulin-like growth factor receptor signaling pathway (GO:0048009)3.73485491
12chondrocyte proliferation (GO:0035988)3.71159537
13embryonic retina morphogenesis in camera-type eye (GO:0060059)3.51914389
14chondrocyte development (GO:0002063)3.51299693
15adherens junction assembly (GO:0034333)3.48215593
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.45786448
17plasma membrane repair (GO:0001778)3.45540651
18cell-substrate adherens junction assembly (GO:0007045)3.45246659
19focal adhesion assembly (GO:0048041)3.45246659
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.40270902
21hippo signaling (GO:0035329)3.36566708
22sequestering of extracellular ligand from receptor (GO:0035581)3.36531592
23* positive regulation of fatty acid beta-oxidation (GO:0032000)3.35098376
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.27787324
25epithelial cell-cell adhesion (GO:0090136)3.24104546
26mesenchymal-epithelial cell signaling (GO:0060638)3.24072716
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.20548039
28cardiac myofibril assembly (GO:0055003)3.19855615
29mesodermal cell differentiation (GO:0048333)3.19289849
30collagen metabolic process (GO:0032963)3.12466621
31regulation of transforming growth factor beta2 production (GO:0032909)3.05709623
32collagen catabolic process (GO:0030574)3.05201048
33endodermal cell differentiation (GO:0035987)3.05200407
34branching involved in mammary gland duct morphogenesis (GO:0060444)3.03097097
35multicellular organismal macromolecule metabolic process (GO:0044259)3.02258812
36* regulation of fatty acid beta-oxidation (GO:0031998)3.00246096
37negative regulation of axon extension involved in axon guidance (GO:0048843)2.99939388
38craniofacial suture morphogenesis (GO:0097094)2.99675215
39polarized epithelial cell differentiation (GO:0030859)2.96720627
40negative regulation of keratinocyte proliferation (GO:0010839)2.96495277
41alpha-linolenic acid metabolic process (GO:0036109)2.96266355
42negative regulation of chondrocyte differentiation (GO:0032331)2.95471622
43* positive regulation of fatty acid oxidation (GO:0046321)2.93932312
44semaphorin-plexin signaling pathway (GO:0071526)2.93008162
45camera-type eye morphogenesis (GO:0048593)2.89859849
46branching involved in salivary gland morphogenesis (GO:0060445)2.89644355
47multicellular organismal metabolic process (GO:0044236)2.88842438
48establishment of apical/basal cell polarity (GO:0035089)2.87258142
49midgut development (GO:0007494)2.87156757
50negative regulation of fatty acid transport (GO:2000192)2.86945813
51cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85304186
52atrioventricular valve morphogenesis (GO:0003181)2.84947954
53notochord development (GO:0030903)2.84385037
54carnitine shuttle (GO:0006853)2.82151001
55multicellular organismal catabolic process (GO:0044243)2.80726363
56heart morphogenesis (GO:0003007)2.79635208
57fatty acid transmembrane transport (GO:1902001)2.78225663
58establishment of tissue polarity (GO:0007164)2.77833904
59establishment of planar polarity (GO:0001736)2.77833904
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.77488443
61endothelial cell morphogenesis (GO:0001886)2.76159453
62non-canonical Wnt signaling pathway (GO:0035567)2.73554476
63negative regulation of axon guidance (GO:1902668)2.72528670
64* positive regulation of glycogen biosynthetic process (GO:0045725)2.71769310
65glomerular filtration (GO:0003094)2.70962930
66negative regulation of catenin import into nucleus (GO:0035414)2.69866666
67Golgi transport vesicle coating (GO:0048200)2.67495590
68COPI coating of Golgi vesicle (GO:0048205)2.67495590
69epoxygenase P450 pathway (GO:0019373)2.66131478
70bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65614632
71extracellular matrix assembly (GO:0085029)2.65593867
72muscle cell migration (GO:0014812)2.65489069
73embryonic eye morphogenesis (GO:0048048)2.64616224
74cochlea morphogenesis (GO:0090103)2.63628737
75skin morphogenesis (GO:0043589)2.63273653
76embryonic foregut morphogenesis (GO:0048617)2.62057709
77* positive regulation of mesenchymal cell proliferation (GO:0002053)2.61927518
78prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.61738330
79embryonic camera-type eye morphogenesis (GO:0048596)2.60535091
80dermatan sulfate biosynthetic process (GO:0030208)2.57347121
81myofibril assembly (GO:0030239)2.56949048
82protein localization to microtubule (GO:0035372)2.56508700
83outer ear morphogenesis (GO:0042473)2.55772273
84endocardial cushion development (GO:0003197)2.55356721
85renal filtration (GO:0097205)2.53587903
86negative regulation of cartilage development (GO:0061037)2.53416415
87negative regulation of osteoblast proliferation (GO:0033689)2.52835009
88extracellular matrix disassembly (GO:0022617)2.52807964
89glomerular basement membrane development (GO:0032836)2.52238881
90negative regulation of stem cell proliferation (GO:2000647)2.51183236
91embryonic cranial skeleton morphogenesis (GO:0048701)2.51126122
92endothelial cell chemotaxis (GO:0035767)2.50703678
93gap junction assembly (GO:0016264)2.50060997
94gastrulation with mouth forming second (GO:0001702)2.50038582
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.48700656
96negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.48468502
97heparan sulfate proteoglycan metabolic process (GO:0030201)2.48088120
98cell migration involved in sprouting angiogenesis (GO:0002042)2.48031293
99apical protein localization (GO:0045176)2.47131837
100paraxial mesoderm development (GO:0048339)2.46625776
101regulation of cardioblast differentiation (GO:0051890)2.46578721
102* regulation of mesenchymal cell proliferation (GO:0010464)2.46385998
103cell proliferation involved in metanephros development (GO:0072203)2.45886564
104* regulation of fatty acid oxidation (GO:0046320)2.45435000
105lung epithelium development (GO:0060428)2.45066847
106metanephric mesenchyme development (GO:0072075)2.44965016
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44942281
108* positive regulation of glycogen metabolic process (GO:0070875)2.44389553
109adherens junction organization (GO:0034332)2.44200495
110protein retention in ER lumen (GO:0006621)2.43403421
111cell junction assembly (GO:0034329)2.42320159
112trabecula formation (GO:0060343)2.42279527
113type B pancreatic cell proliferation (GO:0044342)2.41668983
114regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.41148134
115regulation of catenin import into nucleus (GO:0035412)2.40945907
116positive regulation of catenin import into nucleus (GO:0035413)2.40626506
117basement membrane organization (GO:0071711)2.38977971
118convergent extension (GO:0060026)2.38938892
119apoptotic cell clearance (GO:0043277)2.38768369
120protein hydroxylation (GO:0018126)2.37654485
121positive regulation of extracellular matrix organization (GO:1903055)2.37521262
122establishment of monopolar cell polarity (GO:0061162)2.37372620
123establishment or maintenance of monopolar cell polarity (GO:0061339)2.37372620
124blood vessel endothelial cell migration (GO:0043534)2.36924838
125negative regulation of cell fate specification (GO:0009996)2.36122053
126asymmetric protein localization (GO:0008105)2.35924835
127mammary gland epithelial cell proliferation (GO:0033598)2.35285287
128positive regulation of osteoblast proliferation (GO:0033690)2.34652945
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.34233242
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34218573
131cellular response to vitamin (GO:0071295)2.33962882
132negative regulation of fibrinolysis (GO:0051918)2.33711370
133negative regulation of embryonic development (GO:0045992)2.33529703
134sarcomere organization (GO:0045214)2.32826073
135myoblast fusion (GO:0007520)2.32030209
136regulation of sequestering of triglyceride (GO:0010889)2.31899381
137lateral sprouting from an epithelium (GO:0060601)2.31513241
138cranial suture morphogenesis (GO:0060363)2.31021453
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30549458
140protein localization to cell surface (GO:0034394)2.30313911
141muscle filament sliding (GO:0030049)2.30228726
142actin-myosin filament sliding (GO:0033275)2.30228726
143branching involved in prostate gland morphogenesis (GO:0060442)2.30180999
144regulation of axon guidance (GO:1902667)2.29242699
145regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28922828
146low-density lipoprotein particle clearance (GO:0034383)2.28846338
147regulation of establishment of planar polarity (GO:0090175)2.28113362
148kidney mesenchyme development (GO:0072074)2.27797984
149regulation of axon extension involved in axon guidance (GO:0048841)2.27762156
1502-oxoglutarate metabolic process (GO:0006103)2.27522635
151dermatan sulfate metabolic process (GO:0030205)2.27076059
152eye morphogenesis (GO:0048592)2.25296247
153cell adhesion mediated by integrin (GO:0033627)2.23853845
154cardiac muscle cell proliferation (GO:0060038)2.23648353
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21991781
156negative chemotaxis (GO:0050919)2.21636103
157negative regulation of cell size (GO:0045792)2.21617164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.34381525
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16804490
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95686134
4ZNF263_19887448_ChIP-Seq_K562_Human2.63170610
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59784210
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.46617996
7CLOCK_20551151_ChIP-Seq_293T_Human2.46054650
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.30485806
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25491760
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.21810691
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20642837
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18427060
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.14981305
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11025557
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08654547
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02768721
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95441155
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.87247104
19* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86342961
20* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86236879
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.86091698
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82469598
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81282300
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81162536
25* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79218605
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77887424
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.75619775
28RACK7_27058665_Chip-Seq_MCF-7_Human1.75359339
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73553173
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73553173
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.73226255
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73162366
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73162366
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72509328
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72074640
36CJUN_26792858_Chip-Seq_BT549_Human1.71427966
37* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69473030
38* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69473030
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68669954
40* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65221168
41* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64394933
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61779886
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60124978
44* ISL1_27105846_Chip-Seq_CPCs_Mouse1.58634045
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55158512
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53494076
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50724180
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50695172
49* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49943726
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48579682
51AR_21909140_ChIP-Seq_LNCAP_Human1.47969562
52* UBF1/2_26484160_Chip-Seq_HMECs_Human1.47476768
53BRD4_25478319_ChIP-Seq_HGPS_Human1.47146218
54AR_21572438_ChIP-Seq_LNCaP_Human1.46418938
55* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45067842
56TP53_16413492_ChIP-PET_HCT116_Human1.43693717
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43516341
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42213606
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42160904
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41597839
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.40692347
62* EZH2_27304074_Chip-Seq_ESCs_Mouse1.40069043
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.38536406
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.38536406
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38214551
66AHR_22903824_ChIP-Seq_MCF-7_Human1.37864259
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37619415
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36838344
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.36803260
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36432263
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36431106
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36309945
73* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35266587
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35156778
75GBX2_23144817_ChIP-Seq_PC3_Human1.35150862
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34944882
77* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34751071
78* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34154249
79TP53_22127205_ChIP-Seq_IMR90_Human1.33966565
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33834495
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33086217
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32112841
83TP53_18474530_ChIP-ChIP_U2OS_Human1.30647792
84* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30132701
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29988552
86KDM2B_26808549_Chip-Seq_K562_Human1.29959658
87ATF3_27146783_Chip-Seq_COLON_Human1.29789241
88* ESR2_21235772_ChIP-Seq_MCF-7_Human1.27246588
89* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26262600
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24928341
91* ERG_21242973_ChIP-ChIP_JURKAT_Human1.24299312
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.23848977
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23550836
94* RNF2_27304074_Chip-Seq_ESCs_Mouse1.23031055
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.22378923
96* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21001918
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20942730
98* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20816257
99* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20814438
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19436084
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19182628
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18494714
103* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18089357
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17074563
105* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14570582
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13772312
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12912741
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11952944
109DROSHA_22980978_ChIP-Seq_HELA_Human1.11891609
110BCAT_22108803_ChIP-Seq_LS180_Human1.11553541
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.10306172
112* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09729777
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09548573
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09069248
115* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08973997
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06484970
117TP53_23651856_ChIP-Seq_MEFs_Mouse1.06338752
118* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06307478
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04887742
120* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04341969
121* FOXO3_23340844_ChIP-Seq_DLD1_Human1.04106907
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03140309
123KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03107917
124RXR_22108803_ChIP-Seq_LS180_Human1.03092281
125TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02601236
126* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02569744
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02467255
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02207831
129* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02186592
130AR_19668381_ChIP-Seq_PC3_Human1.02142886
131TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01473319
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00027115
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98874242
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98649105
135* SOX2_20726797_ChIP-Seq_SW620_Human0.97931603
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97663389
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97557161
138* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97380101
139LXR_22292898_ChIP-Seq_THP-1_Human0.96272941
140* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96042145
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93926553
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93600661
143* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92984331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.35099604
2MP0005503_abnormal_tendon_morphology4.22228896
3MP0005275_abnormal_skin_tensile4.15175500
4MP0003705_abnormal_hypodermis_morpholog3.65687751
5MP0002837_dystrophic_cardiac_calcinosis2.78840808
6MP0004272_abnormal_basement_membrane2.62367325
7MP0000751_myopathy2.34479521
8MP0009384_cardiac_valve_regurgitation2.30520673
9MP0003941_abnormal_skin_development2.30395420
10MP0003279_aneurysm2.18436907
11MP0002108_abnormal_muscle_morphology2.11708012
12MP0001849_ear_inflammation2.04677107
13MP0001299_abnormal_eye_distance/1.98333652
14MP0010030_abnormal_orbit_morphology1.96387590
15MP0009250_abnormal_appendicular_skeleto1.83886703
16MP0010234_abnormal_vibrissa_follicle1.81204174
17MP0005623_abnormal_meninges_morphology1.74552332
18MP0001958_emphysema1.73927813
19MP0000467_abnormal_esophagus_morphology1.73109979
20MP0004130_abnormal_muscle_cell1.68653814
21MP0009780_abnormal_chondrocyte_physiolo1.66595743
22MP0005409_darkened_coat_color1.66591671
23MP0005508_abnormal_skeleton_morphology1.65996528
24MP0009053_abnormal_anal_canal1.63907561
25MP0003385_abnormal_body_wall1.62427693
26MP0002282_abnormal_trachea_morphology1.61051203
27MP0002139_abnormal_hepatobiliary_system1.59933308
28MP0005257_abnormal_intraocular_pressure1.55045793
29* MP0002896_abnormal_bone_mineralization1.54963981
30MP0005670_abnormal_white_adipose1.54956605
31MP0000462_abnormal_digestive_system1.54648155
32MP0004084_abnormal_cardiac_muscle1.53881568
33MP0002249_abnormal_larynx_morphology1.50897295
34MP0002877_abnormal_melanocyte_morpholog1.50602760
35MP0005666_abnormal_adipose_tissue1.49099897
36MP0002796_impaired_skin_barrier1.48797020
37MP0000733_abnormal_muscle_development1.47999360
38MP0003942_abnormal_urinary_system1.47768890
39MP0004134_abnormal_chest_morphology1.46249789
40MP0000749_muscle_degeneration1.46123316
41MP0002060_abnormal_skin_morphology1.45209325
42MP0004087_abnormal_muscle_fiber1.42338221
43MP0004185_abnormal_adipocyte_glucose1.41985534
44MP0000566_synostosis1.36591100
45MP0003252_abnormal_bile_duct1.36270716
46MP0003950_abnormal_plasma_membrane1.35893137
47MP0000534_abnormal_ureter_morphology1.35056284
48MP0000013_abnormal_adipose_tissue1.34253558
49MP0000537_abnormal_urethra_morphology1.33476325
50MP0000428_abnormal_craniofacial_morphol1.31383304
51MP0005248_abnormal_Harderian_gland1.30500364
52MP0003115_abnormal_respiratory_system1.30123135
53MP0004233_abnormal_muscle_weight1.27544113
54* MP0000163_abnormal_cartilage_morphology1.25288739
55MP0004145_abnormal_muscle_electrophysio1.24913876
56MP0005375_adipose_tissue_phenotype1.24578489
57MP0005360_urolithiasis1.23087414
58MP0000003_abnormal_adipose_tissue1.23067272
59MP0004858_abnormal_nervous_system1.20715084
60MP0000750_abnormal_muscle_regeneration1.18382188
61MP0003937_abnormal_limbs/digits/tail_de1.17834655
62MP0010352_gastrointestinal_tract_polyps1.17806418
63MP0002168_other_aberrant_phenotype1.16916601
64MP0002932_abnormal_joint_morphology1.16136598
65MP0005501_abnormal_skin_physiology1.16032950
66MP0002098_abnormal_vibrissa_morphology1.15586346
67MP0003755_abnormal_palate_morphology1.14943617
68MP0006054_spinal_hemorrhage1.14934660
69MP0005330_cardiomyopathy1.13342260
70MP0003935_abnormal_craniofacial_develop1.13144913
71* MP0002115_abnormal_skeleton_extremities1.11809515
72MP0000759_abnormal_skeletal_muscle1.11102832
73MP0002295_abnormal_pulmonary_circulatio1.10545001
74MP0000383_abnormal_hair_follicle1.09861784
75MP0003122_maternal_imprinting1.09332105
76MP0003453_abnormal_keratinocyte_physiol1.08539548
77MP0003283_abnormal_digestive_organ1.07001050
78MP0010678_abnormal_skin_adnexa1.06815025
79MP0005365_abnormal_bile_salt1.05827102
80MP0010630_abnormal_cardiac_muscle1.05242815
81MP0003091_abnormal_cell_migration1.04531627
82MP0001542_abnormal_bone_strength1.03678922
83MP0006138_congestive_heart_failure1.03197201
84MP0004215_abnormal_myocardial_fiber1.02590446
85MP0004036_abnormal_muscle_relaxation1.02553506
86MP0005369_muscle_phenotype1.01246546
87MP0003566_abnormal_cell_adhesion1.00799253
88MP0000569_abnormal_digit_pigmentation0.99148503
89MP0005620_abnormal_muscle_contractility0.97454479
90MP0002233_abnormal_nose_morphology0.97318278
91MP0000762_abnormal_tongue_morphology0.96842541
92MP0002697_abnormal_eye_size0.95945302
93MP0002116_abnormal_craniofacial_bone0.94824572
94MP0005023_abnormal_wound_healing0.93953567
95MP0003045_fibrosis0.93302582
96MP0008775_abnormal_heart_ventricle0.92481817
97MP0000049_abnormal_middle_ear0.92097001
98MP0000767_abnormal_smooth_muscle0.91092938
99MP0010771_integument_phenotype0.90049103
100MP0001216_abnormal_epidermal_layer0.89749953
101MP0000747_muscle_weakness0.89210914
102MP0000538_abnormal_urinary_bladder0.89020142
103* MP0002109_abnormal_limb_morphology0.88246180
104* MP0002269_muscular_atrophy0.87757218
105MP0005197_abnormal_uvea_morphology0.87725193
106MP0001177_atelectasis0.87693252
107MP0010368_abnormal_lymphatic_system0.87649487
108MP0002972_abnormal_cardiac_muscle0.87538035
109MP0001340_abnormal_eyelid_morphology0.86535892
110MP0000627_abnormal_mammary_gland0.86089889
111MP0000432_abnormal_head_morphology0.86013063
112MP0005187_abnormal_penis_morphology0.85271597
113MP0004264_abnormal_extraembryonic_tissu0.83442352
114MP0001348_abnormal_lacrimal_gland0.83339872
115MP0000377_abnormal_hair_follicle0.82468772
116MP0003137_abnormal_impulse_conducting0.81672873
117MP0003315_abnormal_perineum_morphology0.81345434
118MP0005385_cardiovascular_system_phenoty0.81018685
119MP0001544_abnormal_cardiovascular_syste0.81018685
120MP0002234_abnormal_pharynx_morphology0.80443622
121MP0001243_abnormal_dermal_layer0.80420329
122MP0002106_abnormal_muscle_physiology0.80001692
123MP0000579_abnormal_nail_morphology0.79429757
124MP0002092_abnormal_eye_morphology0.78550606
125* MP0002089_abnormal_postnatal_growth/wei0.78418650
126MP0002177_abnormal_outer_ear0.77673077
127* MP0002113_abnormal_skeleton_development0.77652955
128* MP0005076_abnormal_cell_differentiation0.76360686
129* MP0002111_abnormal_tail_morphology0.75385364
130MP0002128_abnormal_blood_circulation0.75349438
131MP0002114_abnormal_axial_skeleton0.71191296
132MP0009672_abnormal_birth_weight0.69554227
133MP0002925_abnormal_cardiovascular_devel0.68945679
134MP0001286_abnormal_eye_development0.67962828

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.85844702
2Premature rupture of membranes (HP:0001788)4.92595140
3Ankle contracture (HP:0006466)4.54695958
4Shallow orbits (HP:0000586)4.38872432
5Broad metatarsal (HP:0001783)4.33646659
6Type 1 muscle fiber predominance (HP:0003803)4.33480946
7Vascular tortuosity (HP:0004948)3.80659904
8Arterial tortuosity (HP:0005116)3.76892760
9Aortic dissection (HP:0002647)3.44909574
10Short 4th metacarpal (HP:0010044)3.40334709
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.40334709
12Increased connective tissue (HP:0009025)3.29525517
13Follicular hyperkeratosis (HP:0007502)3.15598757
14Atrophic scars (HP:0001075)3.03477115
15Cerebral aneurysm (HP:0004944)2.99435598
16Mitral valve prolapse (HP:0001634)2.96851188
17Abnormality of the 4th metacarpal (HP:0010012)2.89692438
18Neonatal short-limb short stature (HP:0008921)2.88538619
19Soft skin (HP:0000977)2.88422416
20Aortic aneurysm (HP:0004942)2.87887644
21Hypoplastic ischia (HP:0003175)2.87338917
22Cervical subluxation (HP:0003308)2.86954031
23Spinal rigidity (HP:0003306)2.84733786
24Mildly elevated creatine phosphokinase (HP:0008180)2.84518902
25Slender build (HP:0001533)2.81561314
26Peritonitis (HP:0002586)2.81019535
27Bladder diverticulum (HP:0000015)2.78264599
28Bell-shaped thorax (HP:0001591)2.77689167
29Increased variability in muscle fiber diameter (HP:0003557)2.76069733
30Abnormality of the ischium (HP:0003174)2.67657887
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66096653
32Pterygium (HP:0001059)2.61896264
33Dilatation of the ascending aorta (HP:0005111)2.59910754
34Fragile skin (HP:0001030)2.58888168
35Lymphangioma (HP:0100764)2.58816723
36Blue sclerae (HP:0000592)2.56897991
37Wrist flexion contracture (HP:0001239)2.49973562
38Wide anterior fontanel (HP:0000260)2.49636017
39Milia (HP:0001056)2.48523558
40Infantile muscular hypotonia (HP:0008947)2.48486269
41Overgrowth (HP:0001548)2.45426908
42Abnormality of dentin (HP:0010299)2.41276918
43Hyperacusis (HP:0010780)2.40669755
44Genu recurvatum (HP:0002816)2.39212946
45Short nail (HP:0001799)2.38667108
46Natal tooth (HP:0000695)2.36712085
47Broad face (HP:0000283)2.36000367
48Coronal craniosynostosis (HP:0004440)2.34045688
49Abnormality of skeletal muscle fiber size (HP:0012084)2.30594021
50Turricephaly (HP:0000262)2.27907622
51Fragile nails (HP:0001808)2.26966319
52Wormian bones (HP:0002645)2.22761604
53Advanced eruption of teeth (HP:0006288)2.22112875
54Muscle fiber splitting (HP:0003555)2.20817566
55Absent frontal sinuses (HP:0002688)2.20104449
56Hyporeflexia of lower limbs (HP:0002600)2.18858058
57Hyperextensible skin (HP:0000974)2.17038261
58Mitral regurgitation (HP:0001653)2.16521744
59Aneurysm (HP:0002617)2.15301210
60Ectopia lentis (HP:0001083)2.13643507
61Mesomelia (HP:0003027)2.13386831
62Distal lower limb amyotrophy (HP:0008944)2.12660340
63Buphthalmos (HP:0000557)2.10860011
64Deviation of the hallux (HP:0010051)2.10602257
65Biconcave vertebral bodies (HP:0004586)2.10005534
66Abnormality of the calf musculature (HP:0001430)2.09460208
67Exostoses (HP:0100777)2.08913438
68Osteoarthritis (HP:0002758)2.08556663
69Deep venous thrombosis (HP:0002625)2.08038963
70Scapular winging (HP:0003691)2.08013228
71Round ear (HP:0100830)2.05716114
72Selective tooth agenesis (HP:0001592)2.04341031
73Bowel diverticulosis (HP:0005222)2.01570727
74Joint laxity (HP:0001388)2.01219783
75Hip contracture (HP:0003273)2.00815041
76Hallux valgus (HP:0001822)1.99599687
77Distal lower limb muscle weakness (HP:0009053)1.95947693
78Aortic regurgitation (HP:0001659)1.95733957
79Broad ribs (HP:0000885)1.95196334
80Difficulty running (HP:0009046)1.94748388
81Ulnar bowing (HP:0003031)1.92849709
82Vertebral arch anomaly (HP:0008438)1.92555794
83Knee flexion contracture (HP:0006380)1.91900429
84Enlarged penis (HP:0000040)1.90008117
85Limited hip movement (HP:0008800)1.89720416
86Morphological abnormality of the middle ear (HP:0008609)1.89138672
87Elbow flexion contracture (HP:0002987)1.89115648
88Right ventricular cardiomyopathy (HP:0011663)1.87715407
89Cupped ribs (HP:0000887)1.86631683
90Spinal cord lesions (HP:0100561)1.86081547
91Syringomyelia (HP:0003396)1.86081547
92Asymmetry of the thorax (HP:0001555)1.85464004
93Limb-girdle muscle weakness (HP:0003325)1.85095642
94Broad long bones (HP:0005622)1.84643829
95Sudden death (HP:0001699)1.83699917
96Tibial bowing (HP:0002982)1.83682023
97Mitral stenosis (HP:0001718)1.83622877
98Achilles tendon contracture (HP:0001771)1.82910155
99Vertebral compression fractures (HP:0002953)1.82548526
100Bronchomalacia (HP:0002780)1.81771401
101Generalized amyotrophy (HP:0003700)1.81173367
102Aplasia involving bones of the upper limbs (HP:0009823)1.80496197
103Aplasia of the phalanges of the hand (HP:0009802)1.80496197
104Aplasia involving bones of the extremities (HP:0009825)1.80496197
105Camptodactyly of toe (HP:0001836)1.79483414
106Hepatoblastoma (HP:0002884)1.77046983
107Thin ribs (HP:0000883)1.75720494
108Renal duplication (HP:0000075)1.75568880
109Bowing of the arm (HP:0006488)1.74947182
110Bowed forearm bones (HP:0003956)1.74947182
111Alopecia of scalp (HP:0002293)1.74239359
112Striae distensae (HP:0001065)1.73754532
113Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73310656
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.73212364
115Breech presentation (HP:0001623)1.72749299
116Abnormal ossification of hand bones (HP:0005921)1.72529768
117Lipoatrophy (HP:0100578)1.71976713
118Abnormality of the Achilles tendon (HP:0005109)1.71744518
119Long toe (HP:0010511)1.70922573
120Muscle fiber inclusion bodies (HP:0100299)1.70156854
121Hypoalphalipoproteinemia (HP:0003233)1.69986621
122Lower limb amyotrophy (HP:0007210)1.69944078
123Difficulty climbing stairs (HP:0003551)1.68769604
124Abnormal delivery (HP:0001787)1.68682380
125Thin bony cortex (HP:0002753)1.67430323
126Flat acetabular roof (HP:0003180)1.67109605
127Arnold-Chiari malformation (HP:0002308)1.67093691
128Exercise-induced muscle cramps (HP:0003710)1.67089414
129Disproportionate tall stature (HP:0001519)1.66938246
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66537842
131Back pain (HP:0003418)1.66480725
132Exercise-induced myalgia (HP:0003738)1.65977068
133Abnormality of carpal bone ossification (HP:0006257)1.65645107
134Tarsal synostosis (HP:0008368)1.64640751
135Nemaline bodies (HP:0003798)1.64502704
136Skin nodule (HP:0200036)1.63635765
137Microglossia (HP:0000171)1.61077004
138Upper limb amyotrophy (HP:0009129)1.60695999
139Distal upper limb amyotrophy (HP:0007149)1.60695999
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59763010
141Onycholysis (HP:0001806)1.59587563
142Broad phalanx (HP:0006009)1.59358019
143Abnormality of the acetabulum (HP:0003170)1.59082847
144Venous abnormality (HP:0002624)1.58200121
145Hypoventilation (HP:0002791)1.55853983
146Osteolytic defects of the hand bones (HP:0009699)1.55568333
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.55568333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.55992976
2EPHA24.40711676
3LATS14.03955879
4TRIB33.69225159
5TTN3.51905181
6PDGFRA2.98514361
7PKN22.66244866
8FGFR22.65251627
9CAMK1D2.32321383
10EPHB22.28226343
11FRK2.18470986
12RIPK11.97844854
13PIK3CA1.96539764
14CAMK1G1.93789651
15EPHA31.79290247
16SMG11.78835067
17LATS21.78617291
18OBSCN1.77155742
19MUSK1.68884173
20DMPK1.66635546
21FGFR11.55743241
22SCYL21.54738665
23MAP3K101.51965606
24PTK61.48305684
25LMTK21.45359404
26PHKG21.41666869
27PHKG11.41666869
28INSRR1.37983102
29ERN11.35264864
30PAK31.31570492
31ICK1.30807536
32* SIK11.30800689
33STK31.30780476
34FER1.28825300
35MAPKAPK31.23874735
36PDGFRB1.22174436
37PAK21.17117929
38* MTOR1.14871732
39EEF2K1.14760115
40TESK11.13537018
41BCKDK1.07839763
42FGFR31.06887487
43PRKD21.06027378
44PTK21.03942777
45LIMK11.03346678
46MET1.02685781
47BMX1.02234307
48RPS6KB21.00672608
49KSR10.98070878
50IRAK30.96851527
51STK38L0.96759812
52FGFR40.96122610
53* ROCK10.95609118
54PDK40.93229845
55PDK30.93229845
56NEK90.91896028
57NTRK10.88805854
58ERBB20.87620672
59RET0.84854072
60MAP3K70.84464559
61MELK0.80178483
62NUAK10.79807164
63SGK30.75186018
64ERBB30.74098556
65CDK80.73997121
66PRKAA20.71980727
67CAMK2G0.71969054
68ERBB40.71388649
69MOS0.71335042
70CDK60.70213090
71MYLK0.69506892
72PNCK0.68261039
73PRKD10.67846408
74ARAF0.67212257
75ILK0.65795817
76CDC42BPA0.63895934
77CAMK2B0.63675622
78TRPM70.63538905
79TGFBR20.61224024
80PLK20.59791143
81MAP3K60.59372267
82PRKCH0.59024137
83CDK120.59022518
84MAP3K90.57516856
85NEK10.56959384
86SGK20.56184807
87DYRK1B0.55533730
88AKT30.54458749
89PAK60.53869151
90PIM20.53623040
91* PRKAA10.52634279
92MAP2K20.51644363
93CDK70.51521574
94MAP2K10.51428872
95GSK3A0.48715455
96MST1R0.47989483
97ZAK0.47929261
98TYRO30.47459861
99CAMK2D0.47000608
100NTRK20.46859825
101LRRK20.46725277
102NEK60.46480047
103FLT30.46141485
104PIK3CG0.45876797
105WNK10.45225644
106BRD40.42846254
107STK380.42426604
108* ROCK20.41701222
109EPHB10.41249129
110SRC0.40206877
111RPS6KA20.39761976
112RPS6KL10.39758999
113RPS6KC10.39758999
114PAK40.39403550
115PRKG20.38626322
116SGK4940.38617502
117SGK2230.38617502
118AKT20.36361242
119CDK90.36326558
120MAPKAPK20.35765011
121CAMKK10.35429702
122* INSR0.35251382
123MAP3K20.34491175
124PTK2B0.34480066
125PKN10.34459448
126MAP3K120.33924460
127MARK20.33127884
128MARK10.32851185
129MAPK110.32136125
130PRKD30.31940615
131CSNK1G10.31346722
132PRKCI0.30917549
133PDK20.30744425
134BCR0.30378949
135ABL20.28928918
136KSR20.27043614
137MAPK90.23553921
138PDPK10.23065149

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.58476433
2Nitrogen metabolism_Homo sapiens_hsa009102.50554519
3Fatty acid degradation_Homo sapiens_hsa000712.06938266
4Propanoate metabolism_Homo sapiens_hsa006402.06912848
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03852392
6Fatty acid metabolism_Homo sapiens_hsa012122.03725070
7Focal adhesion_Homo sapiens_hsa045101.92992638
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.87881194
9PPAR signaling pathway_Homo sapiens_hsa033201.87675995
10Basal cell carcinoma_Homo sapiens_hsa052171.87173129
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87061772
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86325606
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86124541
14Dilated cardiomyopathy_Homo sapiens_hsa054141.75826947
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73209013
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72549569
17Protein digestion and absorption_Homo sapiens_hsa049741.72111890
18Fatty acid biosynthesis_Homo sapiens_hsa000611.71010066
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65474589
20Thyroid cancer_Homo sapiens_hsa052161.64237457
21Butanoate metabolism_Homo sapiens_hsa006501.57692635
22Tryptophan metabolism_Homo sapiens_hsa003801.54076364
23Arginine biosynthesis_Homo sapiens_hsa002201.53964816
24Lysine degradation_Homo sapiens_hsa003101.53718101
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52880383
26Adherens junction_Homo sapiens_hsa045201.48390363
27Proteoglycans in cancer_Homo sapiens_hsa052051.41515823
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41116014
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36737626
30Hedgehog signaling pathway_Homo sapiens_hsa043401.30564245
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26243800
32Hippo signaling pathway_Homo sapiens_hsa043901.21360639
33Complement and coagulation cascades_Homo sapiens_hsa046101.12985111
34* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12555136
35* Insulin resistance_Homo sapiens_hsa049311.11821204
36* AMPK signaling pathway_Homo sapiens_hsa041521.11464568
37Amoebiasis_Homo sapiens_hsa051461.09945940
38ErbB signaling pathway_Homo sapiens_hsa040121.08842023
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08274774
40Starch and sucrose metabolism_Homo sapiens_hsa005001.06690866
41Pyruvate metabolism_Homo sapiens_hsa006201.05388174
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.01966008
43Carbon metabolism_Homo sapiens_hsa012000.97348478
44Bile secretion_Homo sapiens_hsa049760.97114688
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96891634
46Glucagon signaling pathway_Homo sapiens_hsa049220.95543267
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95118463
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94669181
49Prion diseases_Homo sapiens_hsa050200.94637920
50Viral myocarditis_Homo sapiens_hsa054160.93887270
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92071814
52Caffeine metabolism_Homo sapiens_hsa002320.91773568
53Small cell lung cancer_Homo sapiens_hsa052220.91494348
54Endometrial cancer_Homo sapiens_hsa052130.90289678
55Bladder cancer_Homo sapiens_hsa052190.89695796
56TGF-beta signaling pathway_Homo sapiens_hsa043500.89077275
57* Insulin signaling pathway_Homo sapiens_hsa049100.88048459
58Glioma_Homo sapiens_hsa052140.87944838
59Pentose phosphate pathway_Homo sapiens_hsa000300.86324318
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85529049
61Melanoma_Homo sapiens_hsa052180.85426545
62Axon guidance_Homo sapiens_hsa043600.84183492
63* MicroRNAs in cancer_Homo sapiens_hsa052060.83947426
64beta-Alanine metabolism_Homo sapiens_hsa004100.83210950
65Prostate cancer_Homo sapiens_hsa052150.82167127
66* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81629169
67Sulfur metabolism_Homo sapiens_hsa009200.81374767
68Phenylalanine metabolism_Homo sapiens_hsa003600.80280503
69Tight junction_Homo sapiens_hsa045300.77695477
70* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77332201
71Peroxisome_Homo sapiens_hsa041460.77206967
72Wnt signaling pathway_Homo sapiens_hsa043100.77190337
73Vitamin B6 metabolism_Homo sapiens_hsa007500.76271259
74Chronic myeloid leukemia_Homo sapiens_hsa052200.75250030
75Rap1 signaling pathway_Homo sapiens_hsa040150.75237431
76Steroid biosynthesis_Homo sapiens_hsa001000.74786033
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74492830
78* Adipocytokine signaling pathway_Homo sapiens_hsa049200.73612478
79* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73198873
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71206385
81Melanogenesis_Homo sapiens_hsa049160.70969120
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69423307
83Tyrosine metabolism_Homo sapiens_hsa003500.68565707
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67642833
85N-Glycan biosynthesis_Homo sapiens_hsa005100.66010771
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64718917
87* mTOR signaling pathway_Homo sapiens_hsa041500.63159732
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.62999678
89Biosynthesis of amino acids_Homo sapiens_hsa012300.62618594
90VEGF signaling pathway_Homo sapiens_hsa043700.62392813
91Selenocompound metabolism_Homo sapiens_hsa004500.62056467
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.60617485
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.58362591
94Choline metabolism in cancer_Homo sapiens_hsa052310.58060611
95GnRH signaling pathway_Homo sapiens_hsa049120.57431687
96Inositol phosphate metabolism_Homo sapiens_hsa005620.57344262
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54843676
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.54689279
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.54520055
100Galactose metabolism_Homo sapiens_hsa000520.54319253
101Acute myeloid leukemia_Homo sapiens_hsa052210.52433134
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52383607
103Pathways in cancer_Homo sapiens_hsa052000.51979514
104* Neurotrophin signaling pathway_Homo sapiens_hsa047220.51955608
105Fat digestion and absorption_Homo sapiens_hsa049750.50493057
106Pancreatic cancer_Homo sapiens_hsa052120.50450110
107Fructose and mannose metabolism_Homo sapiens_hsa000510.49492910
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48992670
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48726532
110p53 signaling pathway_Homo sapiens_hsa041150.48030329
111Chemical carcinogenesis_Homo sapiens_hsa052040.47762646
112* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47503173
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46108706
114Estrogen signaling pathway_Homo sapiens_hsa049150.45858604
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45739729
116Circadian rhythm_Homo sapiens_hsa047100.45725305
117Renal cell carcinoma_Homo sapiens_hsa052110.45409140
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44751112
119* Type II diabetes mellitus_Homo sapiens_hsa049300.44615215
120Prolactin signaling pathway_Homo sapiens_hsa049170.44458141
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43436297
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43129187
123Thyroid hormone synthesis_Homo sapiens_hsa049180.42029016
124Non-small cell lung cancer_Homo sapiens_hsa052230.41636096
125Retinol metabolism_Homo sapiens_hsa008300.41481349
126Gap junction_Homo sapiens_hsa045400.40841369
127Colorectal cancer_Homo sapiens_hsa052100.40616764
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39724877
129Notch signaling pathway_Homo sapiens_hsa043300.39593164
130Endocytosis_Homo sapiens_hsa041440.38683262
131Vibrio cholerae infection_Homo sapiens_hsa051100.38386757

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