IRS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)8.79567866
2detection of bacterium (GO:0016045)7.97227904
3mating behavior (GO:0007617)7.75317014
4thyroid hormone generation (GO:0006590)7.01908423
5detection of other organism (GO:0098543)6.72531958
6thyroid gland development (GO:0030878)6.41585955
7nuclear pore complex assembly (GO:0051292)6.41189717
8regulation of secondary heart field cardioblast proliferation (GO:0003266)6.36334163
9regulation of cardioblast proliferation (GO:0003264)6.36334163
10nuclear pore organization (GO:0006999)6.31764160
11receptor guanylyl cyclase signaling pathway (GO:0007168)6.29637151
12DNA replication checkpoint (GO:0000076)5.81577662
13lymph vessel development (GO:0001945)5.70099673
14thyroid hormone metabolic process (GO:0042403)5.55158123
15mitotic chromosome condensation (GO:0007076)5.38870469
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)5.27192858
17peripheral nervous system neuron development (GO:0048935)5.26881593
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.18177278
19proline transport (GO:0015824)5.04957304
20sister chromatid segregation (GO:0000819)5.02093780
21DNA replication initiation (GO:0006270)4.87775030
22pore complex assembly (GO:0046931)4.81837442
23proximal/distal pattern formation (GO:0009954)4.73183979
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.70921884
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66743973
26positive regulation of male gonad development (GO:2000020)4.66081051
27negative regulation of organ growth (GO:0046621)4.60401448
28dosage compensation (GO:0007549)4.59245525
29negative regulation of mRNA processing (GO:0050686)4.56609379
30regulation of mammary gland epithelial cell proliferation (GO:0033599)4.56022181
31regulation of natural killer cell differentiation (GO:0032823)4.52710291
32DNA strand elongation involved in DNA replication (GO:0006271)4.49843634
33cGMP biosynthetic process (GO:0006182)4.48356966
34negative regulation of cell cycle G2/M phase transition (GO:1902750)4.43967341
35DNA synthesis involved in DNA repair (GO:0000731)4.41729457
36negative regulation of histone methylation (GO:0031061)4.31988423
37DNA strand elongation (GO:0022616)4.30439234
38mitotic sister chromatid segregation (GO:0000070)4.30406159
39metanephric mesenchyme development (GO:0072075)4.24158245
40regulation of DNA endoreduplication (GO:0032875)4.12866358
41heterochromatin organization (GO:0070828)4.07296708
42DNA unwinding involved in DNA replication (GO:0006268)4.00681066
43mitotic nuclear envelope disassembly (GO:0007077)4.00660286
44telomere maintenance via semi-conservative replication (GO:0032201)3.90070050
45DNA duplex unwinding (GO:0032508)3.87433552
46negative regulation of mRNA metabolic process (GO:1903312)3.85845400
47negative regulation of RNA splicing (GO:0033119)3.85381963
48regulation of male gonad development (GO:2000018)3.83219974
49peptide hormone processing (GO:0016486)3.82009069
50membrane disassembly (GO:0030397)3.77869687
51nuclear envelope disassembly (GO:0051081)3.77869687
52reproductive behavior (GO:0019098)3.77277815
53DNA geometric change (GO:0032392)3.73251193
54kidney mesenchyme development (GO:0072074)3.72909466
55establishment of nucleus localization (GO:0040023)3.71606877
56viral mRNA export from host cell nucleus (GO:0046784)3.70728895
57multi-organism reproductive behavior (GO:0044705)3.70617023
58regulation of NFAT protein import into nucleus (GO:0051532)3.63257059
59induction of positive chemotaxis (GO:0050930)3.62093421
60embryonic skeletal joint morphogenesis (GO:0060272)3.61858004
61alanine transport (GO:0032328)3.61652173
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59065474
63protein localization to chromosome, centromeric region (GO:0071459)3.57482498
64regulation of translational fidelity (GO:0006450)3.55706452
65regulation of DNA-dependent DNA replication (GO:0090329)3.52142945
66pre-miRNA processing (GO:0031054)3.50757641
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.47770566
68attachment of spindle microtubules to kinetochore (GO:0008608)3.47717323
69double-strand break repair via nonhomologous end joining (GO:0006303)3.46703387
70non-recombinational repair (GO:0000726)3.46703387
71mammary gland epithelial cell differentiation (GO:0060644)3.46294559
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.43263515
73folic acid-containing compound biosynthetic process (GO:0009396)3.43213046
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42927104
75ganglion development (GO:0061548)3.41133154
76anatomical structure arrangement (GO:0048532)3.39198961
77chromatin assembly (GO:0031497)3.36367087
78pharyngeal system development (GO:0060037)3.35765151
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.35688813
80DNA conformation change (GO:0071103)3.35611531
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.33689916
82embryonic heart tube development (GO:0035050)3.33456527
83positive regulation of chromosome segregation (GO:0051984)3.32443944
84sister chromatid cohesion (GO:0007062)3.32163935
85phosphatidylinositol acyl-chain remodeling (GO:0036149)3.31550572
86nuclear envelope organization (GO:0006998)3.31402549
87chromosome condensation (GO:0030261)3.30038307
88phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.29976242
89telomere maintenance via recombination (GO:0000722)3.29504065
90nephron tubule formation (GO:0072079)3.25329125
91regulation of RNA export from nucleus (GO:0046831)3.20954546
92regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.20265795
93neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.19138844
94embryonic skeletal system morphogenesis (GO:0048704)3.19130729
95layer formation in cerebral cortex (GO:0021819)3.17257583
96translesion synthesis (GO:0019985)3.16964087
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16254994
98folic acid metabolic process (GO:0046655)3.16024876
99regulation of histone H3-K4 methylation (GO:0051569)3.12977653
100positive regulation of mitotic sister chromatid separation (GO:1901970)3.12928797
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12928797
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12928797
103meiotic chromosome segregation (GO:0045132)3.11565336
104histone H2B ubiquitination (GO:0033523)3.11056721
105protein complex localization (GO:0031503)3.10685518
106regulation of histone H3-K9 methylation (GO:0051570)3.10121048
107axonal fasciculation (GO:0007413)3.08391637
108regulation of DNA damage checkpoint (GO:2000001)3.08186708
109synaptic vesicle maturation (GO:0016188)3.07923742
110cilium or flagellum-dependent cell motility (GO:0001539)3.07341610
111formation of translation preinitiation complex (GO:0001731)3.07000410
112protein localization to kinetochore (GO:0034501)3.06399883
113protein targeting to Golgi (GO:0000042)3.06018646
114eosinophil chemotaxis (GO:0048245)3.05082338
115cellular protein complex localization (GO:0034629)3.02552714
116maturation of SSU-rRNA (GO:0030490)3.01566296
117rRNA transcription (GO:0009303)3.01397510
118positive regulation of cGMP biosynthetic process (GO:0030828)3.00957639
119RNA stabilization (GO:0043489)2.99485106
120mRNA stabilization (GO:0048255)2.99485106
121forelimb morphogenesis (GO:0035136)2.99403148
122cGMP metabolic process (GO:0046068)2.98714009
123neuron fate specification (GO:0048665)2.98105403
124regulation of centriole replication (GO:0046599)2.97432213
125macroautophagy (GO:0016236)2.96134397
126nucleobase biosynthetic process (GO:0046112)2.95624066
127positive regulation of cell cycle checkpoint (GO:1901978)2.95254663
128microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.94992674
129mRNA transport (GO:0051028)2.94911931
130detection of external biotic stimulus (GO:0098581)2.94822344
131kinetochore organization (GO:0051383)2.93490954
132innervation (GO:0060384)2.92431829
133SMAD protein complex assembly (GO:0007183)2.91844276
134mitotic recombination (GO:0006312)2.91474437
135myoblast migration (GO:0051451)2.90732414
136spindle assembly involved in mitosis (GO:0090307)2.90580510
137establishment of mitotic spindle localization (GO:0040001)2.90486810
138positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.90347312
139replication fork processing (GO:0031297)2.88603627
140cellular potassium ion homeostasis (GO:0030007)2.88094027
141DNA replication-dependent nucleosome organization (GO:0034723)2.87984924
142DNA replication-dependent nucleosome assembly (GO:0006335)2.87984924
143mRNA export from nucleus (GO:0006406)2.86869271
144negative regulation of chromosome segregation (GO:0051985)2.84314505
145cranial nerve morphogenesis (GO:0021602)2.83783513
146regulation of heart morphogenesis (GO:2000826)2.83409918
147histone H2A acetylation (GO:0043968)2.82995562
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.82256946
149nucleus localization (GO:0051647)2.82239188
150negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.79742019
151anterior/posterior pattern specification (GO:0009952)2.78465971
152purine nucleobase biosynthetic process (GO:0009113)2.78183318
153regulation of cGMP biosynthetic process (GO:0030826)2.78109336
154branching involved in prostate gland morphogenesis (GO:0060442)2.78004833
155cranial nerve structural organization (GO:0021604)2.77925856
156mitochondrial RNA metabolic process (GO:0000959)2.77465574
157epithelial cell maturation (GO:0002070)2.76375148
158peptidyl-lysine dimethylation (GO:0018027)2.76029856
159RNA export from nucleus (GO:0006405)2.75989171
160mitochondrial DNA metabolic process (GO:0032042)2.74110365
161DNA biosynthetic process (GO:0071897)2.72568919
162necroptotic process (GO:0070266)2.71440437
163establishment of protein localization to Golgi (GO:0072600)2.71225938
164iron ion import (GO:0097286)2.71162285
165regulation of axon extension involved in axon guidance (GO:0048841)2.70459324
166axon extension involved in axon guidance (GO:0048846)2.69953003
167neuron projection extension involved in neuron projection guidance (GO:1902284)2.69953003
168retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69845821
169negative regulation of axon extension involved in axon guidance (GO:0048843)2.69326364
170neurotransmitter secretion (GO:0007269)2.68433407
171chromatin remodeling at centromere (GO:0031055)2.67834292
172N-glycan processing (GO:0006491)2.66810659
173response to histamine (GO:0034776)2.66491111
174chromosome segregation (GO:0007059)2.66064755
175positive regulation of cGMP metabolic process (GO:0030825)2.65448864
176regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65148038
177vesicle transport along microtubule (GO:0047496)2.63846756
178eosinophil migration (GO:0072677)2.61351161
179CENP-A containing nucleosome assembly (GO:0034080)2.60021072
180DNA packaging (GO:0006323)2.59258023
181stress granule assembly (GO:0034063)2.57990441
182phosphatidylserine acyl-chain remodeling (GO:0036150)2.57780153
183regulation of female receptivity (GO:0045924)2.57082491
184positive regulation of bone resorption (GO:0045780)2.55731879
185endocrine hormone secretion (GO:0060986)11.2783310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79601168
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.60351830
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.82566112
4EZH2_22144423_ChIP-Seq_EOC_Human4.77409335
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.14478389
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.57176986
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.16801630
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12594764
9XRN2_22483619_ChIP-Seq_HELA_Human2.96836232
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75884786
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.73519342
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46281715
13* TTF2_22483619_ChIP-Seq_HELA_Human2.42722141
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41720469
15ZNF263_19887448_ChIP-Seq_K562_Human2.35173603
16GBX2_23144817_ChIP-Seq_PC3_Human2.35116943
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32206157
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27146242
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21084463
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17241119
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15538842
22CIITA_25753668_ChIP-Seq_RAJI_Human2.15454739
23* KDM5A_27292631_Chip-Seq_BREAST_Human2.08837239
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03397866
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02474626
26TAF15_26573619_Chip-Seq_HEK293_Human2.00021664
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99384944
28MYC_22102868_ChIP-Seq_BL_Human1.98195170
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.94549090
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94206328
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91827699
32* FUS_26573619_Chip-Seq_HEK293_Human1.90474889
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90264078
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.86501167
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85563747
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85010895
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81724270
38FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.81679621
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78816658
40* EWS_26573619_Chip-Seq_HEK293_Human1.78490617
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.77322071
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77124976
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.73485200
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72422080
45REST_21632747_ChIP-Seq_MESCs_Mouse1.71747307
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69338738
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.65975001
48ZNF274_21170338_ChIP-Seq_K562_Hela1.64502363
49GABP_19822575_ChIP-Seq_HepG2_Human1.64402955
50E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.63983326
51* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62531866
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62155629
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.61192921
54TP53_16413492_ChIP-PET_HCT116_Human1.61172711
55DCP1A_22483619_ChIP-Seq_HELA_Human1.59981968
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57948270
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57409033
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.57268746
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55930814
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.55132954
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54989656
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53816111
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53192255
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52028101
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49219224
66SMAD4_21799915_ChIP-Seq_A2780_Human1.48889636
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.48776262
68P300_18555785_Chip-Seq_ESCs_Mouse1.44570889
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44218048
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44059849
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43857282
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42752154
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.41594742
74SMAD1_18555785_Chip-Seq_ESCs_Mouse1.41138204
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41090513
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40319615
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39597204
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.39503211
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39137643
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.37664147
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.37254683
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36822924
83RNF2_27304074_Chip-Seq_NSC_Mouse1.35321431
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.35286749
85AR_21909140_ChIP-Seq_LNCAP_Human1.33242979
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32966544
87* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32875894
88* P300_19829295_ChIP-Seq_ESCs_Human1.31777840
89CHD1_26751641_Chip-Seq_LNCaP_Human1.31449665
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30570341
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29096447
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27788463
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27646815
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26469161
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26447030
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26226324
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24559977
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.23701839
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23308487
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22711329
101STAT3_23295773_ChIP-Seq_U87_Human1.22501459
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21179844
103MYC_18940864_ChIP-ChIP_HL60_Human1.20379906
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20279230
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19764752
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19226260
107* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18668370
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18464708
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.18345761
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.17622780
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.17519935
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16789706
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.16467651
114E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16376174
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.16089946
116* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15589555
117* EZH2_27304074_Chip-Seq_ESCs_Mouse1.15496798
118VDR_21846776_ChIP-Seq_THP-1_Human1.14955573
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14947235
120* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14465379
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14059866
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13539428
123IGF1R_20145208_ChIP-Seq_DFB_Human1.12956518
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11393808
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10809739
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09856180
127* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09285845
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.09096544
129* TP53_20018659_ChIP-ChIP_R1E_Mouse1.08674067
130* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08374430
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07594888
132AR_21572438_ChIP-Seq_LNCaP_Human1.06664270
133RARB_27405468_Chip-Seq_BRAIN_Mouse1.05904685
134P53_22387025_ChIP-Seq_ESCs_Mouse1.05683944
135FOXP3_21729870_ChIP-Seq_TREG_Human1.05335746
136* EED_16625203_ChIP-ChIP_MESCs_Mouse1.04719685
137AR_25329375_ChIP-Seq_VCAP_Human1.04386222
138RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04296783
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04094713
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03710636
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01924132
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01186391
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01157894
144E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00339389
145* RUNX2_22187159_ChIP-Seq_PCA_Human1.00095168
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99628984
147PU1_27457419_Chip-Seq_LIVER_Mouse0.98057212
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97551665
149TCF4_23295773_ChIP-Seq_U87_Human0.97497472
150KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96512032
151TFEB_21752829_ChIP-Seq_HELA_Human0.96413198
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96172176
153VDR_23849224_ChIP-Seq_CD4+_Human0.95731202
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.95499306
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93616881
156* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92130111
157* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91634378
158CBP_20019798_ChIP-Seq_JUKART_Human0.91444502
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91444502
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91176542
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90650889
162E2F1_21310950_ChIP-Seq_MCF-7_Human0.90416241
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89431389
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88790749
165* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88606387
166* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88606387
167CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88513245
168TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87637365
169ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87418969
170NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87353812
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84055966
172* RING1B_27294783_Chip-Seq_NPCs_Mouse0.83950450
173NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79620092
174YY1_21170310_ChIP-Seq_MESCs_Mouse0.79244934
175SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78036475
176NANOG_21062744_ChIP-ChIP_HESCs_Human0.77771132
177KDM2B_26808549_Chip-Seq_JURKAT_Human0.77314140
178RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74561457
179KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74189769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology6.56314970
2MP0005187_abnormal_penis_morphology5.58521153
3MP0003315_abnormal_perineum_morphology5.58203257
4MP0008057_abnormal_DNA_replication4.35935925
5MP0003111_abnormal_nucleus_morphology3.86747339
6MP0002249_abnormal_larynx_morphology3.52810350
7MP0005623_abnormal_meninges_morphology3.50223900
8MP0000631_abnormal_neuroendocrine_gland3.27381651
9MP0000681_abnormal_thyroid_gland3.19745218
10MP0002009_preneoplasia3.15291469
11MP0003077_abnormal_cell_cycle3.10738092
12MP0003693_abnormal_embryo_hatching3.05400669
13MP0003123_paternal_imprinting2.96435901
14MP0000537_abnormal_urethra_morphology2.78756584
15MP0003121_genomic_imprinting2.69019222
16MP0003787_abnormal_imprinting2.61299706
17MP0008058_abnormal_DNA_repair2.54257384
18MP0010030_abnormal_orbit_morphology2.44026615
19MP0005646_abnormal_pituitary_gland2.38680946
20MP0003122_maternal_imprinting2.37791794
21MP0008932_abnormal_embryonic_tissue2.28732428
22MP0004957_abnormal_blastocyst_morpholog2.27939785
23MP0001346_abnormal_lacrimal_gland2.27257859
24MP0009780_abnormal_chondrocyte_physiolo2.21979915
25MP0005367_renal/urinary_system_phenotyp2.20685091
26MP0000516_abnormal_urinary_system2.20685091
27MP0001502_abnormal_circadian_rhythm2.20076314
28MP0008007_abnormal_cellular_replicative2.16280078
29MP0002160_abnormal_reproductive_system1.90431222
30MP0004859_abnormal_synaptic_plasticity1.86206916
31MP0000647_abnormal_sebaceous_gland1.81324122
32MP0000350_abnormal_cell_proliferation1.81046973
33MP0006292_abnormal_olfactory_placode1.79052682
34MP0003690_abnormal_glial_cell1.73850344
35MP0001299_abnormal_eye_distance/1.71444113
36MP0010352_gastrointestinal_tract_polyps1.70023052
37MP0003635_abnormal_synaptic_transmissio1.69135404
38MP0003937_abnormal_limbs/digits/tail_de1.64789975
39MP0010234_abnormal_vibrissa_follicle1.62171339
40MP0003786_premature_aging1.61255303
41MP0005386_behavior/neurological_phenoty1.61180796
42MP0004924_abnormal_behavior1.61180796
43MP0000569_abnormal_digit_pigmentation1.61140427
44MP0002697_abnormal_eye_size1.61029257
45MP0008789_abnormal_olfactory_epithelium1.58450948
46MP0001730_embryonic_growth_arrest1.58347223
47MP0000678_abnormal_parathyroid_gland1.56132694
48MP0001188_hyperpigmentation1.55979716
49MP0003890_abnormal_embryonic-extraembry1.54306055
50MP0009053_abnormal_anal_canal1.51387554
51MP0002638_abnormal_pupillary_reflex1.49974497
52MP0009379_abnormal_foot_pigmentation1.49022294
53MP0009697_abnormal_copulation1.48325092
54MP0001661_extended_life_span1.48222733
55MP0000003_abnormal_adipose_tissue1.46066221
56MP0001672_abnormal_embryogenesis/_devel1.46046518
57MP0005380_embryogenesis_phenotype1.46046518
58MP0004185_abnormal_adipocyte_glucose1.45685319
59MP0002085_abnormal_embryonic_tissue1.45083978
60MP0004233_abnormal_muscle_weight1.44955203
61MP0002063_abnormal_learning/memory/cond1.44323074
62MP0005551_abnormal_eye_electrophysiolog1.42195074
63MP0008877_abnormal_DNA_methylation1.41975057
64MP0005076_abnormal_cell_differentiation1.41131016
65MP0009250_abnormal_appendicular_skeleto1.36540167
66MP0001968_abnormal_touch/_nociception1.34983067
67MP0003984_embryonic_growth_retardation1.34444844
68MP0005645_abnormal_hypothalamus_physiol1.33744521
69MP0001293_anophthalmia1.32481630
70MP0000049_abnormal_middle_ear1.31651382
71MP0002932_abnormal_joint_morphology1.31335942
72MP0005503_abnormal_tendon_morphology1.26636000
73MP0002088_abnormal_embryonic_growth/wei1.26292739
74MP0000733_abnormal_muscle_development1.25614558
75MP0002064_seizures1.24663466
76MP0002114_abnormal_axial_skeleton1.23586208
77MP0009745_abnormal_behavioral_response1.23164936
78MP0001697_abnormal_embryo_size1.22954903
79MP0000566_synostosis1.21704979
80MP0001270_distended_abdomen1.21039171
81MP0010307_abnormal_tumor_latency1.20849147
82MP0002092_abnormal_eye_morphology1.19904344
83MP0002877_abnormal_melanocyte_morpholog1.18838299
84MP0000313_abnormal_cell_death1.17683876
85MP0002572_abnormal_emotion/affect_behav1.14932469
86MP0001485_abnormal_pinna_reflex1.13617759
87MP0010094_abnormal_chromosome_stability1.13011420
88MP0001486_abnormal_startle_reflex1.11117240
89MP0002282_abnormal_trachea_morphology1.10945991
90MP0002233_abnormal_nose_morphology1.08555009
91MP0008569_lethality_at_weaning1.08224151
92MP0001286_abnormal_eye_development1.07950691
93MP0002080_prenatal_lethality1.07941240
94MP0006072_abnormal_retinal_apoptosis1.06732402
95* MP0002557_abnormal_social/conspecific_i1.05847962
96MP0009703_decreased_birth_body1.05211897
97MP0002067_abnormal_sensory_capabilities1.03861124
98MP0000428_abnormal_craniofacial_morphol1.03217579
99MP0002751_abnormal_autonomic_nervous1.02975186
100MP0001501_abnormal_sleep_pattern1.02412757
101MP0008995_early_reproductive_senescence1.00351050
102MP0009672_abnormal_birth_weight0.99071715
103MP0002733_abnormal_thermal_nociception0.98118662
104MP0003935_abnormal_craniofacial_develop0.96754807
105MP0000751_myopathy0.96222197
106MP0000639_abnormal_adrenal_gland0.94567914
107MP0000013_abnormal_adipose_tissue0.94180159
108MP0003705_abnormal_hypodermis_morpholog0.93911711
109MP0005171_absent_coat_pigmentation0.93723829
110MP0003646_muscle_fatigue0.92644750
111MP0000427_abnormal_hair_cycle0.92612145
112MP0004043_abnormal_pH_regulation0.92233114
113MP0002098_abnormal_vibrissa_morphology0.91897039
114MP0001727_abnormal_embryo_implantation0.90916760
115MP0003300_gastrointestinal_ulcer0.89466552
116MP0000534_abnormal_ureter_morphology0.89448937
117MP0002108_abnormal_muscle_morphology0.89415999
118MP0002086_abnormal_extraembryonic_tissu0.89035379
119MP0006276_abnormal_autonomic_nervous0.88920688
120MP0008961_abnormal_basal_metabolism0.88797359
121MP0002166_altered_tumor_susceptibility0.88113413
122MP0003283_abnormal_digestive_organ0.87270089
123MP0004782_abnormal_surfactant_physiolog0.86027808
124MP0002234_abnormal_pharynx_morphology0.85626777
125MP0003567_abnormal_fetal_cardiomyocyte0.83768165
126MP0002938_white_spotting0.82829468
127MP0002272_abnormal_nervous_system0.82363228
128MP0002184_abnormal_innervation0.81942514
129MP0004811_abnormal_neuron_physiology0.81668771
130MP0003938_abnormal_ear_development0.81588126
131MP0003943_abnormal_hepatobiliary_system0.81439362
132MP0002152_abnormal_brain_morphology0.80520060
133MP0002210_abnormal_sex_determination0.80336800
134MP0002116_abnormal_craniofacial_bone0.79915571
135MP0005375_adipose_tissue_phenotype0.77808418
136MP0003755_abnormal_palate_morphology0.77520165
137MP0003385_abnormal_body_wall0.76760209
138MP0002109_abnormal_limb_morphology0.76575368
139MP0002111_abnormal_tail_morphology0.76140019
140MP0002081_perinatal_lethality0.75561975
141MP0002909_abnormal_adrenal_gland0.75384016
142MP0003115_abnormal_respiratory_system0.74582469
143MP0000432_abnormal_head_morphology0.74032358
144MP0002277_abnormal_respiratory_mucosa0.73962635
145MP0002163_abnormal_gland_morphology0.73810507
146MP0003942_abnormal_urinary_system0.73265568
147MP0002090_abnormal_vision0.73262628
148MP0003091_abnormal_cell_migration0.72244258
149MP0000778_abnormal_nervous_system0.72076227
150MP0003698_abnormal_male_reproductive0.69741772
151MP0004808_abnormal_hematopoietic_stem0.68891453
152MP0004142_abnormal_muscle_tone0.68201004
153MP0002882_abnormal_neuron_morphology0.67731464
154MP0003950_abnormal_plasma_membrane0.66932354
155MP0001919_abnormal_reproductive_system0.66891764
156MP0002177_abnormal_outer_ear0.66570408
157MP0009046_muscle_twitch0.66520286
158MP0002971_abnormal_brown_adipose0.65647243
159MP0005389_reproductive_system_phenotype0.64503197
160MP0003045_fibrosis0.64408853
161MP0002066_abnormal_motor_capabilities/c0.62967613
162MP0001145_abnormal_male_reproductive0.62624936
163MP0005253_abnormal_eye_physiology0.62462257
164MP0001963_abnormal_hearing_physiology0.62226385
165MP0001929_abnormal_gametogenesis0.61528845
166MP0003880_abnormal_central_pattern0.61266386
167MP0005647_abnormal_sex_gland0.60392499
168MP0005423_abnormal_somatic_nervous0.59708331
169MP0004197_abnormal_fetal_growth/weight/0.59562122
170MP0003861_abnormal_nervous_system0.59284049
171MP0002084_abnormal_developmental_patter0.59132503
172MP0000371_diluted_coat_color0.58144645
173MP0001943_abnormal_respiration0.57880117
174MP0000653_abnormal_sex_gland0.57440423
175MP0004270_analgesia0.57025747
176MP0002006_tumorigenesis0.56783060

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)6.32361520
2Macroorchidism (HP:0000053)5.60212707
3Lip pit (HP:0100267)5.30776824
4Volvulus (HP:0002580)5.25071687
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65991221
6Chromsome breakage (HP:0040012)4.56827379
7Papilledema (HP:0001085)4.29279869
8Hypogonadotrophic hypogonadism (HP:0000044)4.06023417
9Abnormal number of incisors (HP:0011064)3.99988057
10Ankyloglossia (HP:0010296)3.92812985
11Abnormality of the phalanges of the hallux (HP:0010057)3.84930114
12Agitation (HP:0000713)3.60443986
13Hyperthyroidism (HP:0000836)3.52758891
14Abnormality of cochlea (HP:0000375)3.49401562
15Hypochromic microcytic anemia (HP:0004840)3.44441428
16Conjunctival telangiectasia (HP:0000524)3.42219518
17Increased nuchal translucency (HP:0010880)3.37009551
18Neonatal hypoglycemia (HP:0001998)3.35113772
19Testicular neoplasm (HP:0010788)3.34389698
20Truncal obesity (HP:0001956)3.32832302
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28031375
22Birth length less than 3rd percentile (HP:0003561)3.26800371
23Intestinal fistula (HP:0100819)3.25926171
24Calcaneovalgus deformity (HP:0001848)3.25796565
25Obsessive-compulsive behavior (HP:0000722)3.21698014
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17641671
27Transposition of the great arteries (HP:0001669)3.16374248
28Abnormal connection of the cardiac segments (HP:0011545)3.16374248
29Abnormal ventriculo-arterial connection (HP:0011563)3.16374248
30Truncal ataxia (HP:0002078)3.16015095
31Abnormality of the fetal cardiovascular system (HP:0010948)3.12120435
32Abnormal umbilical cord blood vessels (HP:0011403)3.12120435
33Single umbilical artery (HP:0001195)3.12120435
34High anterior hairline (HP:0009890)3.11269662
35Impulsivity (HP:0100710)3.09615951
36Ectopic kidney (HP:0000086)3.06399519
37Heterotopia (HP:0002282)3.04988106
38Inappropriate behavior (HP:0000719)3.03835198
39Menstrual irregularities (HP:0000858)3.00269705
40Abnormality of the fingertips (HP:0001211)2.98956714
41Primary amenorrhea (HP:0000786)2.97823310
42Subcapsular cataract (HP:0000523)2.95389447
43Hypercortisolism (HP:0001578)2.95305463
44Double outlet right ventricle (HP:0001719)2.87596794
45Congenital malformation of the right heart (HP:0011723)2.87596794
46Abnormality of oral frenula (HP:0000190)2.85973411
47Action tremor (HP:0002345)2.82771940
48Proximal placement of thumb (HP:0009623)2.82049911
49Rectal fistula (HP:0100590)2.81144266
50Rectovaginal fistula (HP:0000143)2.81144266
51Decreased testicular size (HP:0008734)2.81125381
52Optic nerve coloboma (HP:0000588)2.78367611
53Deformed tarsal bones (HP:0008119)2.78017822
54Broad distal phalanx of finger (HP:0009836)2.77983724
55Abnormality of the aortic arch (HP:0012303)2.77961452
56Astrocytoma (HP:0009592)2.75533530
57Abnormality of the astrocytes (HP:0100707)2.75533530
58Protruding tongue (HP:0010808)2.73413172
59Short 5th finger (HP:0009237)2.72595735
60Absence seizures (HP:0002121)2.71153068
61Abnormality of the distal phalanx of the thumb (HP:0009617)2.71147941
62Midline defect of the nose (HP:0004122)2.69741272
63Dysmetric saccades (HP:0000641)2.68539554
64Sensory axonal neuropathy (HP:0003390)2.67602847
65Progressive muscle weakness (HP:0003323)2.66596553
66Duplication of thumb phalanx (HP:0009942)2.61260867
67Excessive salivation (HP:0003781)2.58695983
68Drooling (HP:0002307)2.58695983
69Pheochromocytoma (HP:0002666)2.55910445
70Preauricular pit (HP:0004467)2.54968277
71Periauricular skin pits (HP:0100277)2.54968277
72Increased number of teeth (HP:0011069)2.54932474
73Lymphangioma (HP:0100764)2.53422182
74Abnormality of chromosome segregation (HP:0002916)2.51365449
75Facial cleft (HP:0002006)2.51360580
76Deviation of the thumb (HP:0009603)2.50220612
77Morphological abnormality of the inner ear (HP:0011390)2.49886141
78Broad-based gait (HP:0002136)2.49234365
79Sacral dimple (HP:0000960)2.48365102
80Absent radius (HP:0003974)2.47042685
81X-linked recessive inheritance (HP:0001419)2.45629150
82Preauricular skin tag (HP:0000384)2.44887245
83Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.44419250
84Short thumb (HP:0009778)2.44250771
85Depression (HP:0000716)2.42440651
86Tapered finger (HP:0001182)2.38419445
87Insidious onset (HP:0003587)2.38062273
88Termporal pattern (HP:0011008)2.38062273
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38026583
90Visual hallucinations (HP:0002367)2.35066045
91Short middle phalanx of the 5th finger (HP:0004220)2.34544135
92Abnormality of the calcaneus (HP:0008364)2.33814506
93Vaginal fistula (HP:0004320)2.31450403
94Colon cancer (HP:0003003)2.30981888
95Bifid tongue (HP:0010297)2.29726569
96Impaired social interactions (HP:0000735)2.29426978
97Abnormal social behavior (HP:0012433)2.29426978
98Absent forearm bone (HP:0003953)2.28992948
99Aplasia involving forearm bones (HP:0009822)2.28992948
100Reticulocytopenia (HP:0001896)2.28155372
101Focal seizures (HP:0007359)2.27011361
102Urethral obstruction (HP:0000796)2.26686469
103Neoplasm of the adrenal cortex (HP:0100641)2.25002439
104Skin tags (HP:0010609)2.23110594
105Cupped ear (HP:0000378)2.22265084
106Ulnar bowing (HP:0003031)2.21728702
107Aqueductal stenosis (HP:0002410)2.20100468
108Dialeptic seizures (HP:0011146)2.19535110
109Progressive cerebellar ataxia (HP:0002073)2.18636810
110Myokymia (HP:0002411)2.18332546
111Triphalangeal thumb (HP:0001199)2.18239035
112Coronal craniosynostosis (HP:0004440)2.17771266
113Aplasia/Hypoplasia of the uvula (HP:0010293)2.16414721
114Abnormality of ocular smooth pursuit (HP:0000617)2.15457745
115Abnormality of homocysteine metabolism (HP:0010919)2.15146152
116Homocystinuria (HP:0002156)2.15146152
117Postural tremor (HP:0002174)2.11802657
118Hypopigmentation of the fundus (HP:0007894)2.10958029
119Patellar aplasia (HP:0006443)2.10943863
120Long eyelashes (HP:0000527)2.09521184
121Ependymoma (HP:0002888)2.08813692
122Abnormality of the corticospinal tract (HP:0002492)2.08160112
123Abnormality of the 4th metacarpal (HP:0010012)2.08106619
124Short 1st metacarpal (HP:0010034)2.07645795
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07645795
126Multiple enchondromatosis (HP:0005701)2.07175874
127Anal stenosis (HP:0002025)2.07083975
128Neuroendocrine neoplasm (HP:0100634)2.06386126
129Impaired smooth pursuit (HP:0007772)2.05821326
130Short middle phalanx of finger (HP:0005819)2.05364062
131Intellectual disability, mild (HP:0001256)2.05102139
132Poor eye contact (HP:0000817)2.03407521
133Microvesicular hepatic steatosis (HP:0001414)2.03318391
134Abnormality of the umbilical cord (HP:0010881)2.03199310
135Dysdiadochokinesis (HP:0002075)2.02493474
136Abnormality of the columella (HP:0009929)2.02320897
137Preaxial hand polydactyly (HP:0001177)2.01907188
138Glioma (HP:0009733)2.01682464
139Meckel diverticulum (HP:0002245)2.00692111
140Hyperventilation (HP:0002883)2.00585842
141Overriding aorta (HP:0002623)1.99676717
142Aplasia/Hypoplasia of the patella (HP:0006498)1.98168368
143Abnormality of the ileum (HP:0001549)1.98054826
144Bifid scrotum (HP:0000048)1.96962027
145Rectal prolapse (HP:0002035)1.95063488
146Skin pits (HP:0100276)1.94944203
147Bilateral microphthalmos (HP:0007633)1.94914542
148Renal dysplasia (HP:0000110)1.94900601
149Hemorrhage of the eye (HP:0011885)1.94270995
150Hepatoblastoma (HP:0002884)1.93877117
151Anxiety (HP:0000739)1.93850014
152Osteomalacia (HP:0002749)1.93757927
153Atresia of the external auditory canal (HP:0000413)1.92244701
154Partial duplication of thumb phalanx (HP:0009944)1.92173247
155Abnormality of chromosome stability (HP:0003220)1.91925798
156Attention deficit hyperactivity disorder (HP:0007018)1.91166979
157Esophageal atresia (HP:0002032)1.90378929
158Tented upper lip vermilion (HP:0010804)1.90028474
159Pigmentary retinal degeneration (HP:0001146)1.87940217
160Hyperacusis (HP:0010780)1.87880162
161Ureteral stenosis (HP:0000071)1.87364313
162Abnormality of the preputium (HP:0100587)1.86991215
163Abnormality of the nasal septum (HP:0000419)1.86884865
164Trigonocephaly (HP:0000243)1.86699150
165Disinhibition (HP:0000734)1.86574474
166Abnormality of the incisor (HP:0000676)1.86458618
167Impaired vibration sensation in the lower limbs (HP:0002166)1.86086241
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85816893
169Short 4th metacarpal (HP:0010044)1.85816893
170Fair hair (HP:0002286)1.85075578
171Sloping forehead (HP:0000340)1.84091342
172Urinary urgency (HP:0000012)1.83222951
173Preaxial foot polydactyly (HP:0001841)1.83142803
174Abnormal hair whorl (HP:0010721)1.82673938
175Asymmetric growth (HP:0100555)1.81862056
176Pseudobulbar signs (HP:0002200)1.79523263
177Abnormality of the distal phalanges of the toes (HP:0010182)1.79463938
178Generalized hypopigmentation of hair (HP:0011358)1.78960497
179Diastasis recti (HP:0001540)1.77862437
180Pointed chin (HP:0000307)1.75420942
181Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75318260
182Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75039368
183Degeneration of the lateral corticospinal tracts (HP:0002314)1.75039368
184Aplasia/Hypoplasia of the nipples (HP:0006709)1.73981709
185Renovascular hypertension (HP:0100817)1.70555842
186Hypophosphatemic rickets (HP:0004912)1.70054458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.19106705
2NTRK33.65927356
3MELK3.42605976
4YES13.15593842
5SCYL22.91180418
6CDC72.88812520
7UHMK12.69645655
8ICK2.67691671
9ACVR1B2.66986332
10MAP3K22.56277436
11BUB12.54709114
12MAP3K92.53484764
13TRPM72.52069475
14WNK32.47180867
15CDK62.46171941
16CDK122.37632319
17MKNK22.33751433
18GRK52.27729041
19FGFR22.23843359
20SMG12.14129465
21NEK12.07829843
22BRSK12.02386397
23DYRK1B1.97785249
24MAP3K101.90035521
25KSR21.86361865
26MKNK11.85653830
27MAP2K41.75519084
28BCR1.71088621
29MAP3K41.71087400
30MINK11.70567257
31NTRK21.69004389
32TTK1.68760054
33IRAK31.68198168
34BRSK21.65576403
35KSR11.54446715
36ERBB31.52857973
37KDR1.46287289
38BRD41.44402850
39CDC42BPA1.37086849
40CDK81.29317024
41MARK11.27394758
42WEE11.27317695
43FRK1.25445939
44AURKB1.23336462
45CDK41.20982140
46CDK71.19529783
47RET1.16577545
48FGFR31.15621518
49MTOR1.14275042
50PLK31.12032370
51PAK31.11908248
52HIPK21.10153326
53PAK61.09251791
54CDK31.05102364
55NEK21.04113721
56PNCK1.02907646
57CSNK1A1L0.98752130
58PLK40.98066126
59CAMKK20.97595139
60MAPK110.97113088
61BMPR1B0.93088975
62RIPK40.92760289
63RIPK10.90960284
64CSNK1G10.89967652
65AURKA0.87942721
66CDK190.87701195
67LATS10.82499673
68MAP3K120.82499169
69STK40.82393146
70CAMK40.82028616
71ZAK0.81174268
72CAMK1G0.80260337
73FGFR10.80006917
74MAP2K70.77316630
75MAP3K70.76782557
76AKT30.73614781
77ATM0.73229335
78BRAF0.72868588
79NME20.72607251
80PLK20.70715549
81STK110.68573859
82CDK50.67719647
83CDK10.67152117
84ILK0.66730065
85PRKAA10.66338567
86MAP2K30.65753899
87ATR0.63214877
88CSNK1G20.62244625
89MAPK100.60749822
90CDK140.60424602
91CHEK10.60387937
92CAMK2A0.59113266
93PIM10.59068472
94RPS6KB20.57939423
95PKN20.57780404
96CDK20.57354944
97SGK10.56859583
98CHEK20.56285549
99TYRO30.56024259
100TRIB30.55961920
101CAMK1D0.54787875
102IRAK20.53341595
103RPS6KA50.53286209
104PLK10.51563833
105WNK10.47417309
106STK390.46662685
107PHKG10.43953227
108PHKG20.43953227
109CASK0.43346226
110TNIK0.42501357
111CSNK1E0.42253345
112RPS6KA60.42040477
113PRKDC0.41678781
114DYRK1A0.41479033
115CDK180.41427230
116LMTK20.41172482
117SRPK10.40600051
118GSK3B0.40421261
119ADRBK10.39901236
120CDK90.39325127
121MAPK140.38731008
122CDK150.37726390
123MAP3K50.37465455
124OXSR10.37424721
125ALK0.37403764
126AKT10.37180347
127CSNK1D0.36505278
128RPS6KA10.36001401
129RPS6KA30.35788585
130MAP2K10.35574070
131NEK90.35148309
132RPS6KB10.34825769
133JAK20.33244274
134VRK10.32747164
135AKT20.32565538
136PRKAA20.32162868
137RPS6KC10.32122751
138RPS6KL10.32122751
139CAMK2D0.31457730
140CSNK1G30.31296218
141PRKCH0.30940316
142SGK30.30885609
143SIK20.29233228
144CSNK2A20.28621412
145MAPK150.28095662
146MAP3K130.27811176
147STK160.27602995
148EIF2AK20.25338726
149CDK11A0.24993780
150MAP3K80.24870935
151TAF10.23546011
152CSNK2A10.23440256
153MAPKAPK50.22539687

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.59807323
2Ovarian steroidogenesis_Homo sapiens_hsa049134.20480987
3GnRH signaling pathway_Homo sapiens_hsa049124.16730628
4Non-homologous end-joining_Homo sapiens_hsa034503.88646874
5Homologous recombination_Homo sapiens_hsa034403.26370714
6One carbon pool by folate_Homo sapiens_hsa006703.06759366
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03431547
8Phototransduction_Homo sapiens_hsa047443.01574862
9Spliceosome_Homo sapiens_hsa030402.98485559
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89348192
11Base excision repair_Homo sapiens_hsa034102.87956662
12RNA transport_Homo sapiens_hsa030132.72093218
13Fanconi anemia pathway_Homo sapiens_hsa034602.62803030
14Nicotine addiction_Homo sapiens_hsa050332.55210348
15RNA polymerase_Homo sapiens_hsa030202.39956367
16* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.31928906
17Nucleotide excision repair_Homo sapiens_hsa034202.25098997
18mRNA surveillance pathway_Homo sapiens_hsa030152.21562621
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16114463
20Thyroid hormone synthesis_Homo sapiens_hsa049182.13564446
21Dorso-ventral axis formation_Homo sapiens_hsa043202.12552884
22Serotonergic synapse_Homo sapiens_hsa047262.11545651
23Sulfur relay system_Homo sapiens_hsa041222.03843981
24Linoleic acid metabolism_Homo sapiens_hsa005911.97556018
25GABAergic synapse_Homo sapiens_hsa047271.97064664
26Circadian entrainment_Homo sapiens_hsa047131.96934657
27Long-term depression_Homo sapiens_hsa047301.90552459
28Pyrimidine metabolism_Homo sapiens_hsa002401.89105157
29Ether lipid metabolism_Homo sapiens_hsa005651.74085786
30Glutamatergic synapse_Homo sapiens_hsa047241.67453554
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61680760
32Morphine addiction_Homo sapiens_hsa050321.61110205
33Prolactin signaling pathway_Homo sapiens_hsa049171.60462551
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56242692
35Dopaminergic synapse_Homo sapiens_hsa047281.55720488
36Oocyte meiosis_Homo sapiens_hsa041141.53792954
37Selenocompound metabolism_Homo sapiens_hsa004501.52445405
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39753774
39Cell cycle_Homo sapiens_hsa041101.35035051
40VEGF signaling pathway_Homo sapiens_hsa043701.33731124
41Long-term potentiation_Homo sapiens_hsa047201.32818618
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26122877
43Vitamin B6 metabolism_Homo sapiens_hsa007501.22534995
44Synaptic vesicle cycle_Homo sapiens_hsa047211.22195291
45RNA degradation_Homo sapiens_hsa030181.21269239
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20799255
47Basal transcription factors_Homo sapiens_hsa030221.19649958
48Bladder cancer_Homo sapiens_hsa052191.18817612
49Amphetamine addiction_Homo sapiens_hsa050311.13646429
50Biosynthesis of amino acids_Homo sapiens_hsa012301.13027993
51Purine metabolism_Homo sapiens_hsa002301.12530307
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12508995
53Hedgehog signaling pathway_Homo sapiens_hsa043401.11895402
54* Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11817316
55Choline metabolism in cancer_Homo sapiens_hsa052311.11657404
56Cholinergic synapse_Homo sapiens_hsa047251.06365900
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.04690144
58Oxytocin signaling pathway_Homo sapiens_hsa049211.03228967
59Butanoate metabolism_Homo sapiens_hsa006501.00132464
60Colorectal cancer_Homo sapiens_hsa052100.99792931
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99595491
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99259095
63p53 signaling pathway_Homo sapiens_hsa041150.98980006
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96750954
65Insulin secretion_Homo sapiens_hsa049110.92374810
66Notch signaling pathway_Homo sapiens_hsa043300.91408759
67Fatty acid biosynthesis_Homo sapiens_hsa000610.91331016
68Circadian rhythm_Homo sapiens_hsa047100.89277829
69TGF-beta signaling pathway_Homo sapiens_hsa043500.86841354
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86829885
71Basal cell carcinoma_Homo sapiens_hsa052170.86169240
72Melanogenesis_Homo sapiens_hsa049160.84038368
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81845309
74Renin secretion_Homo sapiens_hsa049240.80298230
75Cocaine addiction_Homo sapiens_hsa050300.79291338
76mTOR signaling pathway_Homo sapiens_hsa041500.77521392
77Ribosome_Homo sapiens_hsa030100.76514510
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75768158
79ErbB signaling pathway_Homo sapiens_hsa040120.75721864
80Salivary secretion_Homo sapiens_hsa049700.73961089
81Systemic lupus erythematosus_Homo sapiens_hsa053220.73524646
82Pyruvate metabolism_Homo sapiens_hsa006200.72875779
83Mismatch repair_Homo sapiens_hsa034300.72511499
84Viral carcinogenesis_Homo sapiens_hsa052030.72300620
85Estrogen signaling pathway_Homo sapiens_hsa049150.71848823
86Taste transduction_Homo sapiens_hsa047420.71681765
87MAPK signaling pathway_Homo sapiens_hsa040100.70765928
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68831283
89HTLV-I infection_Homo sapiens_hsa051660.68096493
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67724394
91Axon guidance_Homo sapiens_hsa043600.66421416
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.66267814
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.64294612
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63860422
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63710681
96* AMPK signaling pathway_Homo sapiens_hsa041520.63032844
97Gastric acid secretion_Homo sapiens_hsa049710.60157737
98Glioma_Homo sapiens_hsa052140.59929783
99Gap junction_Homo sapiens_hsa045400.59384813
100Small cell lung cancer_Homo sapiens_hsa052220.59361946
101Alcoholism_Homo sapiens_hsa050340.58792310
102Fatty acid metabolism_Homo sapiens_hsa012120.58651951
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58622665
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58035069
105MicroRNAs in cancer_Homo sapiens_hsa052060.57696835
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57676453
107Epstein-Barr virus infection_Homo sapiens_hsa051690.57616112
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57584343
109Prion diseases_Homo sapiens_hsa050200.57482606
110Melanoma_Homo sapiens_hsa052180.57400098
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57250518
112Glucagon signaling pathway_Homo sapiens_hsa049220.55909835
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.55081116
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.54875613
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.54871386
116Pancreatic cancer_Homo sapiens_hsa052120.53864071
117Olfactory transduction_Homo sapiens_hsa047400.53034363
118Folate biosynthesis_Homo sapiens_hsa007900.52407104
119Lysine degradation_Homo sapiens_hsa003100.51611691
120Pentose phosphate pathway_Homo sapiens_hsa000300.51302522
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50872610
122Ras signaling pathway_Homo sapiens_hsa040140.50326882
123Wnt signaling pathway_Homo sapiens_hsa043100.48712676
124Chronic myeloid leukemia_Homo sapiens_hsa052200.47387376
125Adherens junction_Homo sapiens_hsa045200.46659237
126Arginine and proline metabolism_Homo sapiens_hsa003300.46569011
127* FoxO signaling pathway_Homo sapiens_hsa040680.46368480
128Renal cell carcinoma_Homo sapiens_hsa052110.45174675
129Thyroid cancer_Homo sapiens_hsa052160.45061700
130* Type II diabetes mellitus_Homo sapiens_hsa049300.45008373
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44714186
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44700780
133DNA replication_Homo sapiens_hsa030300.44280028
134Herpes simplex infection_Homo sapiens_hsa051680.43535953
135Apoptosis_Homo sapiens_hsa042100.42523911
136Dilated cardiomyopathy_Homo sapiens_hsa054140.42505071
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.42334503
138Acute myeloid leukemia_Homo sapiens_hsa052210.42139523
139Prostate cancer_Homo sapiens_hsa052150.41701295
140Mineral absorption_Homo sapiens_hsa049780.41586770
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39002504
142Inositol phosphate metabolism_Homo sapiens_hsa005620.38136351
143Non-small cell lung cancer_Homo sapiens_hsa052230.36996279
144* Adipocytokine signaling pathway_Homo sapiens_hsa049200.36529684
145Platelet activation_Homo sapiens_hsa046110.35447378
146Fructose and mannose metabolism_Homo sapiens_hsa000510.35430389
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35407080
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35345593
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34566576
150Endometrial cancer_Homo sapiens_hsa052130.33963164
151* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33849609
152Hippo signaling pathway_Homo sapiens_hsa043900.33796924
153Bile secretion_Homo sapiens_hsa049760.33574533
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33227813
155* Insulin signaling pathway_Homo sapiens_hsa049100.31929352
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30569871
157Carbon metabolism_Homo sapiens_hsa012000.27698837
158Hepatitis B_Homo sapiens_hsa051610.27689443
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24906510
160Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24058423
161Glycerolipid metabolism_Homo sapiens_hsa005610.19945958
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18160499
163RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17398920
164Maturity onset diabetes of the young_Homo sapiens_hsa049500.16302147

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