IRX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)8.58148257
2* pattern specification involved in kidney development (GO:0061004)8.28949826
3chemical homeostasis within a tissue (GO:0048875)6.83611839
4cytoplasmic mRNA processing body assembly (GO:0033962)6.70253014
5heart valve formation (GO:0003188)5.87483859
6negative regulation of oligodendrocyte differentiation (GO:0048715)5.52662639
7startle response (GO:0001964)5.43263601
8behavioral response to nicotine (GO:0035095)5.38905035
9neuronal stem cell maintenance (GO:0097150)5.34877037
10positive regulation of vascular permeability (GO:0043117)5.33190538
11hemidesmosome assembly (GO:0031581)5.07453727
12atrioventricular valve morphogenesis (GO:0003181)4.53307216
13insulin-like growth factor receptor signaling pathway (GO:0048009)4.49658323
14negative regulation of fatty acid transport (GO:2000192)4.42741857
15radial glial cell differentiation (GO:0060019)4.34630174
16skin morphogenesis (GO:0043589)4.32200177
17maternal behavior (GO:0042711)4.07659037
18axon ensheathment in central nervous system (GO:0032291)4.07617034
19central nervous system myelination (GO:0022010)4.07617034
20glucocorticoid biosynthetic process (GO:0006704)4.05615349
21* segment specification (GO:0007379)4.03576159
22negative regulation of keratinocyte proliferation (GO:0010839)4.00483596
23behavioral response to ethanol (GO:0048149)3.92787310
24neuron fate determination (GO:0048664)3.92347610
25astrocyte differentiation (GO:0048708)3.92091533
26negative regulation of glucose import (GO:0046325)3.91484219
27positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.86929499
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.85573949
29multicellular organismal movement (GO:0050879)3.84644139
30musculoskeletal movement (GO:0050881)3.84644139
31protein heterotrimerization (GO:0070208)3.81783073
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75870105
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.74606311
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.72736367
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.72174434
36embryonic retina morphogenesis in camera-type eye (GO:0060059)3.69936153
37dendritic spine morphogenesis (GO:0060997)3.64749530
38establishment of planar polarity (GO:0001736)3.63714164
39establishment of tissue polarity (GO:0007164)3.63714164
40lens fiber cell development (GO:0070307)3.62097208
41mitotic cell cycle arrest (GO:0071850)3.58797602
42endodermal cell differentiation (GO:0035987)3.52545217
43mitotic G1 DNA damage checkpoint (GO:0031571)3.50519744
44polarized epithelial cell differentiation (GO:0030859)3.50097154
45response to morphine (GO:0043278)3.49492654
46Notch signaling involved in heart development (GO:0061314)3.49461009
47parental behavior (GO:0060746)3.47714405
48cranial suture morphogenesis (GO:0060363)3.47480386
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.42368308
50branching involved in salivary gland morphogenesis (GO:0060445)3.40135967
51response to isoquinoline alkaloid (GO:0014072)3.40053757
52mesodermal cell differentiation (GO:0048333)3.39047994
53cell-substrate junction assembly (GO:0007044)3.37524727
54mating behavior (GO:0007617)3.37073431
55craniofacial suture morphogenesis (GO:0097094)3.36445729
56basement membrane organization (GO:0071711)3.35723161
57auditory receptor cell differentiation (GO:0042491)3.30524692
58camera-type eye morphogenesis (GO:0048593)3.30012923
59epithelial cell differentiation involved in prostate gland development (GO:0060742)3.27576571
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.27247475
61lung-associated mesenchyme development (GO:0060484)3.26803175
62mitotic G1/S transition checkpoint (GO:0044819)3.24244301
63type B pancreatic cell proliferation (GO:0044342)3.24191436
64growth hormone receptor signaling pathway (GO:0060396)3.24191426
65keratinocyte development (GO:0003334)3.24074749
66forebrain neuron development (GO:0021884)3.23123907
67outer ear morphogenesis (GO:0042473)3.22725441
68hippo signaling (GO:0035329)3.21973971
69G1 DNA damage checkpoint (GO:0044783)3.21946972
70lung lobe morphogenesis (GO:0060463)3.21691558
71regulation of hippo signaling (GO:0035330)3.20888278
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.14180580
73mammary gland epithelial cell differentiation (GO:0060644)3.12987468
74desmosome organization (GO:0002934)3.12564763
75epithelial cell-cell adhesion (GO:0090136)3.10912615
76regulation of p38MAPK cascade (GO:1900744)3.09992323
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.09397482
78axonal fasciculation (GO:0007413)3.08784744
79axis elongation (GO:0003401)3.08584103
80metanephros development (GO:0001656)3.08347203
81ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.07548060
82pyrimidine nucleobase catabolic process (GO:0006208)3.07436861
83epithelial tube branching involved in lung morphogenesis (GO:0060441)3.06972277
84suckling behavior (GO:0001967)3.05852802
85spinal cord development (GO:0021510)3.04546335
86embryonic body morphogenesis (GO:0010172)3.04545995
87establishment of apical/basal cell polarity (GO:0035089)3.02357509
88negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.01766977
89axon extension involved in axon guidance (GO:0048846)3.01705746
90neuron projection extension involved in neuron projection guidance (GO:1902284)3.01705746
91bone morphogenesis (GO:0060349)3.01501228
92neuron recognition (GO:0008038)3.01500126
93presynaptic membrane assembly (GO:0097105)3.01434895
94collagen fibril organization (GO:0030199)2.99989611
95forebrain neuron differentiation (GO:0021879)2.99738203
96positive regulation of astrocyte differentiation (GO:0048711)2.98570171
97embryonic cranial skeleton morphogenesis (GO:0048701)2.98230902
98Sertoli cell development (GO:0060009)2.96743454
99cell adhesion mediated by integrin (GO:0033627)2.95765594
100mesenchymal-epithelial cell signaling (GO:0060638)2.95271738
101bone trabecula formation (GO:0060346)2.95166800
102virion attachment to host cell (GO:0019062)2.94892931
103adhesion of symbiont to host cell (GO:0044650)2.94892931
104endocardial cushion development (GO:0003197)2.93876336
105regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.93125804
106regulation of cell fate specification (GO:0042659)2.91922684
107wound healing, spreading of epidermal cells (GO:0035313)2.90968509
108somatic stem cell division (GO:0048103)2.89830300
109ectoderm development (GO:0007398)2.89498534
110negative regulation of smooth muscle cell migration (GO:0014912)2.88993802
111postsynaptic membrane organization (GO:0001941)2.88895624
112negative regulation of glial cell differentiation (GO:0045686)2.88330083
113presynaptic membrane organization (GO:0097090)2.88258829
114peptidyl-proline hydroxylation (GO:0019511)2.88103507
115establishment of nucleus localization (GO:0040023)2.86164258
116digestive tract morphogenesis (GO:0048546)2.84180774
117chondrocyte proliferation (GO:0035988)2.83511734
118lateral sprouting from an epithelium (GO:0060601)2.82737833
119negative regulation of cell fate specification (GO:0009996)2.81041684
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80206372
121regulation of somitogenesis (GO:0014807)2.79638992
122renal filtration (GO:0097205)2.79172482
123retinal ganglion cell axon guidance (GO:0031290)2.79130671
124forebrain development (GO:0030900)2.78245804
125positive regulation of p38MAPK cascade (GO:1900745)2.77257230
126cranial nerve development (GO:0021545)2.76679613
127cell migration in hindbrain (GO:0021535)2.75253526
128positive regulation of mesenchymal cell proliferation (GO:0002053)2.74385319
129collecting duct development (GO:0072044)2.73033695
130nucleobase catabolic process (GO:0046113)2.72678179
131neural tube development (GO:0021915)2.72639489
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.72209563
133nephron epithelium morphogenesis (GO:0072088)2.71939600
134nephron tubule morphogenesis (GO:0072078)2.71939600
135urogenital system development (GO:0001655)2.70902112
136negative regulation of glucose transport (GO:0010829)2.70009548
137cellular response to growth hormone stimulus (GO:0071378)2.68934487
138* proximal/distal pattern formation (GO:0009954)2.68384871
139phosphate ion transmembrane transport (GO:0035435)2.68306861
140trivalent inorganic anion homeostasis (GO:0072506)2.68112453
141phosphate ion homeostasis (GO:0055062)2.68112453
142renal system development (GO:0072001)2.67424124
143regulation of astrocyte differentiation (GO:0048710)2.67287013
144protein localization to endosome (GO:0036010)2.67195273
145regulation of axon extension involved in axon guidance (GO:0048841)2.66565665
146collagen catabolic process (GO:0030574)2.66055931
147positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65858178
148collagen metabolic process (GO:0032963)2.65772985
149ventricular septum morphogenesis (GO:0060412)2.64949744
150cellular response to vitamin D (GO:0071305)2.64614222
151lens morphogenesis in camera-type eye (GO:0002089)2.64187464
152adhesion of symbiont to host (GO:0044406)2.64163468
153negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.63908080
154adherens junction assembly (GO:0034333)2.63637330
155multicellular organismal macromolecule metabolic process (GO:0044259)2.63040413
156extracellular matrix disassembly (GO:0022617)2.61685245
157synaptic transmission, cholinergic (GO:0007271)2.61062804
158lung alveolus development (GO:0048286)2.61017358
159astrocyte development (GO:0014002)2.59137196
160outflow tract septum morphogenesis (GO:0003148)2.57910265
161regulation of heart morphogenesis (GO:2000826)2.57834736
162positive regulation of Notch signaling pathway (GO:0045747)2.57639021
163retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57221648
164cellular response to vitamin (GO:0071295)2.57087685
165telencephalon development (GO:0021537)2.56710368
166lung secretory cell differentiation (GO:0061140)2.56499333
167cerebral cortex radially oriented cell migration (GO:0021799)2.55905740
168body morphogenesis (GO:0010171)2.55689799
169positive regulation of histone deacetylation (GO:0031065)2.55164837
170multicellular organismal catabolic process (GO:0044243)2.54617109
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54159879
172spinal cord motor neuron differentiation (GO:0021522)2.53911738
173midbrain development (GO:0030901)2.53779263
174phosphate ion transport (GO:0006817)2.53490626
175cell fate commitment involved in formation of primary germ layer (GO:0060795)2.53001406
176paraxial mesoderm development (GO:0048339)2.52723339
177limb development (GO:0060173)2.52540468
178appendage development (GO:0048736)2.52540468
179convergent extension (GO:0060026)2.50967451
180negative regulation of catenin import into nucleus (GO:0035414)2.50344649
181establishment of monopolar cell polarity (GO:0061162)2.49728441
182establishment or maintenance of monopolar cell polarity (GO:0061339)2.49728441
183apical protein localization (GO:0045176)2.49484014
184central nervous system neuron development (GO:0021954)2.49335743
185regulation of mesenchymal cell proliferation (GO:0010464)2.48850271
186glomerular filtration (GO:0003094)2.48249483
187cell migration involved in sprouting angiogenesis (GO:0002042)2.47707848
188axon extension (GO:0048675)2.47470466
189negative regulation of neuron differentiation (GO:0045665)2.46447888
190negative regulation of astrocyte differentiation (GO:0048712)2.46327224
191negative regulation of axon extension involved in axon guidance (GO:0048843)2.45954126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.64169950
2EZH2_22144423_ChIP-Seq_EOC_Human5.34739236
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.87395713
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.35236259
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21687375
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02515093
7ZNF263_19887448_ChIP-Seq_K562_Human2.75226187
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.72350465
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.67066514
10* CBX2_27304074_Chip-Seq_ESCs_Mouse2.64050453
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.59415336
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57876504
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.56013713
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43052861
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36814950
16CLOCK_20551151_ChIP-Seq_293T_Human2.34984248
17GBX2_23144817_ChIP-Seq_PC3_Human2.28885224
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24064851
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06211861
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03544590
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01111021
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.98151674
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96935791
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96325456
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96325456
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96325456
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94781395
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94747610
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.92352361
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92026367
31RACK7_27058665_Chip-Seq_MCF-7_Human1.88613589
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88066747
33* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79822501
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76253713
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74597319
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.72999691
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67892090
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67037261
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66431689
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66170568
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64515255
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63003606
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62058701
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61108357
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.59348220
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.58831800
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58161302
48KDM2B_26808549_Chip-Seq_K562_Human1.57138512
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57056028
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.56097209
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56047844
52RNF2_27304074_Chip-Seq_NSC_Mouse1.55910405
53AHR_22903824_ChIP-Seq_MCF-7_Human1.54748896
54SOX2_20726797_ChIP-Seq_SW620_Human1.54187767
55* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51672832
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50732217
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50732217
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.50081056
59* EED_16625203_ChIP-ChIP_MESCs_Mouse1.49909220
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47149000
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47072113
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45902912
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.45721270
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45672809
65REST_21632747_ChIP-Seq_MESCs_Mouse1.43897939
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43155120
67* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42080516
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.41400423
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.41400423
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39789651
71* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39725055
72* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39725055
73CJUN_26792858_Chip-Seq_BT549_Human1.38915552
74LXR_22292898_ChIP-Seq_THP-1_Human1.36852725
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.36567478
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.36138792
77* TP53_20018659_ChIP-ChIP_R1E_Mouse1.35312336
78* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35212528
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32416197
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32086828
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31360883
82* UBF1/2_26484160_Chip-Seq_HMECs_Human1.31141364
83* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30057993
84* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29263220
85* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28814709
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.28634959
87* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28276711
88* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27938305
89* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27487326
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25541906
91* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25152273
92KLF5_25053715_ChIP-Seq_YYC3_Human1.25033545
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23741816
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22758223
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22022165
96* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20037118
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20005324
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.19682539
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18693780
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17289260
101* RNF2_27304074_Chip-Seq_ESCs_Mouse1.17283433
102ATF3_27146783_Chip-Seq_COLON_Human1.16874800
103* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15390616
104* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15253930
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.14782843
106AR_21572438_ChIP-Seq_LNCaP_Human1.14617684
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13186974
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13186974
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.12542391
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12361777
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12167760
112KDM2B_26808549_Chip-Seq_DND41_Human1.12155376
113* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11904223
114* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11719160
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.11201150
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.10230676
117* TP53_18474530_ChIP-ChIP_U2OS_Human1.09874373
118SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07842687
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.07742104
120CREB1_26743006_Chip-Seq_LNCaP_Human1.07120069
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06153964
122RING1B_27294783_Chip-Seq_ESCs_Mouse1.05889110
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05397923
124* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04579239
125GATA4_25053715_ChIP-Seq_YYC3_Human1.02233220
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02111966
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01817825
128TP53_16413492_ChIP-PET_HCT116_Human1.01726768
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01664060
130TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01219237
131DROSHA_22980978_ChIP-Seq_HELA_Human1.01016946
132LXR_22158963_ChIP-Seq_LIVER_Mouse1.00816961
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99558273
134BRD4_25478319_ChIP-Seq_HGPS_Human0.99483667
135* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99480149
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99365283
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98800653
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98532827
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.97681696
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97149018
141WDR5_24793694_ChIP-Seq_LNCAP_Human0.96905581
142* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96871946
143* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96816684
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.95815567
145RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95706875
146* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95320092
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92991649
148ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91008127
149CTCF_27219007_Chip-Seq_Bcells_Human0.90909524
150PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90433807
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89844827
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89686678
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.86780409
154* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84529972
155POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84181008
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83743553
157* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82532782
158* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82417504
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82394862
160* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82380056
161* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81177849
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79504968
163SALL1_21062744_ChIP-ChIP_HESCs_Human0.77930521
164ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76621075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.99629850
2MP0004782_abnormal_surfactant_physiolog4.26359394
3MP0008438_abnormal_cutaneous_collagen4.09322376
4MP0001958_emphysema4.07464076
5MP0010234_abnormal_vibrissa_follicle3.42981806
6MP0002653_abnormal_ependyma_morphology3.31612643
7MP0000778_abnormal_nervous_system3.27286139
8MP0005275_abnormal_skin_tensile3.19131055
9MP0003705_abnormal_hypodermis_morpholog2.85973929
10MP0000566_synostosis2.72850229
11MP0005623_abnormal_meninges_morphology2.52733948
12MP0003787_abnormal_imprinting2.42360626
13MP0004272_abnormal_basement_membrane2.40841289
14MP0010030_abnormal_orbit_morphology2.33172878
15MP0001177_atelectasis2.27125496
16MP0001881_abnormal_mammary_gland2.26402346
17MP0004859_abnormal_synaptic_plasticity2.25331683
18MP0003566_abnormal_cell_adhesion2.17462829
19MP0002295_abnormal_pulmonary_circulatio2.17140552
20MP0001984_abnormal_olfaction2.16579761
21MP0000579_abnormal_nail_morphology2.15732528
22MP0005171_absent_coat_pigmentation2.09543854
23MP0006292_abnormal_olfactory_placode2.01944328
24MP0005083_abnormal_biliary_tract2.01666670
25MP0001188_hyperpigmentation1.91116007
26MP0000537_abnormal_urethra_morphology1.90614423
27MP0005503_abnormal_tendon_morphology1.89021556
28MP0002060_abnormal_skin_morphology1.85001148
29MP0002796_impaired_skin_barrier1.81861177
30MP0005377_hearing/vestibular/ear_phenot1.77642171
31MP0003878_abnormal_ear_physiology1.77642171
32MP0002282_abnormal_trachea_morphology1.76861923
33MP0005388_respiratory_system_phenotype1.72795586
34MP0002133_abnormal_respiratory_system1.72795586
35MP0005076_abnormal_cell_differentiation1.71464090
36MP0002098_abnormal_vibrissa_morphology1.69887574
37MP0003115_abnormal_respiratory_system1.67894606
38MP0006054_spinal_hemorrhage1.64599366
39MP0008995_early_reproductive_senescence1.64547989
40MP0000516_abnormal_urinary_system1.64473555
41MP0005367_renal/urinary_system_phenotyp1.64473555
42MP0003300_gastrointestinal_ulcer1.64460041
43MP0002638_abnormal_pupillary_reflex1.63354082
44MP0009053_abnormal_anal_canal1.61558389
45MP0000955_abnormal_spinal_cord1.59144751
46MP0000762_abnormal_tongue_morphology1.58906074
47MP0001849_ear_inflammation1.57597030
48MP0001502_abnormal_circadian_rhythm1.56759596
49MP0000534_abnormal_ureter_morphology1.56209752
50MP0003879_abnormal_hair_cell1.56113097
51MP0008004_abnormal_stomach_pH1.55920800
52MP0003279_aneurysm1.55213027
53MP0010678_abnormal_skin_adnexa1.54460268
54MP0009384_cardiac_valve_regurgitation1.52001186
55MP0004381_abnormal_hair_follicle1.51180868
56MP0000026_abnormal_inner_ear1.49527084
57MP0001286_abnormal_eye_development1.48409920
58MP0003385_abnormal_body_wall1.48263891
59MP0005257_abnormal_intraocular_pressure1.45417894
60MP0000627_abnormal_mammary_gland1.42276855
61MP0003283_abnormal_digestive_organ1.40225721
62MP0010368_abnormal_lymphatic_system1.40178758
63MP0002234_abnormal_pharynx_morphology1.39753183
64MP0002877_abnormal_melanocyte_morpholog1.38973648
65MP0001542_abnormal_bone_strength1.37578736
66MP0005023_abnormal_wound_healing1.35669858
67MP0005409_darkened_coat_color1.35584889
68MP0003121_genomic_imprinting1.32860452
69MP0003942_abnormal_urinary_system1.32553213
70MP0001485_abnormal_pinna_reflex1.31628540
71MP0000003_abnormal_adipose_tissue1.29176547
72MP0005248_abnormal_Harderian_gland1.28833633
73MP0002876_abnormal_thyroid_physiology1.28102200
74MP0003861_abnormal_nervous_system1.27101025
75MP0002152_abnormal_brain_morphology1.26952325
76MP0005508_abnormal_skeleton_morphology1.26466615
77MP0002254_reproductive_system_inflammat1.26040862
78MP0002896_abnormal_bone_mineralization1.25062776
79MP0000049_abnormal_middle_ear1.24193846
80MP0004133_heterotaxia1.23928576
81MP0003329_amyloid_beta_deposits1.23484154
82MP0003453_abnormal_keratinocyte_physiol1.21664030
83MP0001879_abnormal_lymphatic_vessel1.19837383
84MP0005375_adipose_tissue_phenotype1.19073394
85MP0004185_abnormal_adipocyte_glucose1.18992022
86MP0002063_abnormal_learning/memory/cond1.16689981
87MP0003091_abnormal_cell_migration1.16268480
88MP0000631_abnormal_neuroendocrine_gland1.16248360
89MP0003632_abnormal_nervous_system1.15724672
90MP0000377_abnormal_hair_follicle1.14789558
91MP0005501_abnormal_skin_physiology1.13907483
92MP0002572_abnormal_emotion/affect_behav1.12489599
93MP0002882_abnormal_neuron_morphology1.12271926
94MP0002184_abnormal_innervation1.11599489
95MP0001486_abnormal_startle_reflex1.11559613
96MP0000462_abnormal_digestive_system1.10008408
97MP0003959_abnormal_lean_body1.10004557
98MP0000569_abnormal_digit_pigmentation1.09195765
99MP0004858_abnormal_nervous_system1.08795851
100MP0002557_abnormal_social/conspecific_i1.08492032
101MP0002938_white_spotting1.08316929
102MP0000383_abnormal_hair_follicle1.07911228
103MP0004142_abnormal_muscle_tone1.07886776
104MP0003634_abnormal_glial_cell1.07553457
105MP0003045_fibrosis1.06697870
106MP0005174_abnormal_tail_pigmentation1.05149925
107MP0009250_abnormal_appendicular_skeleto1.03723929
108MP0009379_abnormal_foot_pigmentation1.02615101
109MP0000733_abnormal_muscle_development1.00100288
110MP0003635_abnormal_synaptic_transmissio0.99935293
111MP0001346_abnormal_lacrimal_gland0.99467887
112MP0003938_abnormal_ear_development0.99459229
113MP0003011_delayed_dark_adaptation0.98824907
114MP0001529_abnormal_vocalization0.98645440
115MP0000013_abnormal_adipose_tissue0.97438048
116MP0001243_abnormal_dermal_layer0.97329608
117MP0000428_abnormal_craniofacial_morphol0.96842850
118MP0002932_abnormal_joint_morphology0.96684813
119MP0001175_abnormal_lung_morphology0.96635266
120MP0010352_gastrointestinal_tract_polyps0.95100286
121MP0002752_abnormal_somatic_nervous0.94615950
122MP0001340_abnormal_eyelid_morphology0.94484481
123MP0010771_integument_phenotype0.94043771
124MP0002095_abnormal_skin_pigmentation0.92625973
125MP0001216_abnormal_epidermal_layer0.91371252
126MP0005666_abnormal_adipose_tissue0.91180129
127MP0003122_maternal_imprinting0.90003348
128MP0009745_abnormal_behavioral_response0.89536874
129MP0001348_abnormal_lacrimal_gland0.89329433
130MP0002168_other_aberrant_phenotype0.88787119
131MP0002233_abnormal_nose_morphology0.88514815
132MP0000767_abnormal_smooth_muscle0.86599672
133MP0005423_abnormal_somatic_nervous0.84372351
134MP0005195_abnormal_posterior_eye0.84084322
135MP0000163_abnormal_cartilage_morphology0.83047373
136MP0003724_increased_susceptibility_to0.81834882
137MP0002081_perinatal_lethality0.81135523
138MP0003755_abnormal_palate_morphology0.80695332
139MP0000467_abnormal_esophagus_morphology0.80388690
140MP0002138_abnormal_hepatobiliary_system0.80141359
141MP0001299_abnormal_eye_distance/0.79961249
142MP0000432_abnormal_head_morphology0.79119367
143MP0003941_abnormal_skin_development0.79029781
144MP0002249_abnormal_larynx_morphology0.77158375
145MP0004885_abnormal_endolymph0.76986906
146MP0003936_abnormal_reproductive_system0.75692101
147MP0004019_abnormal_vitamin_homeostasis0.75605618
148MP0002116_abnormal_craniofacial_bone0.75363093
149MP0003935_abnormal_craniofacial_develop0.73184217
150MP0002067_abnormal_sensory_capabilities0.72888416
151MP0006276_abnormal_autonomic_nervous0.72730295
152MP0003567_abnormal_fetal_cardiomyocyte0.71914902
153MP0003448_altered_tumor_morphology0.69639420
154MP0003937_abnormal_limbs/digits/tail_de0.69484619
155MP0002925_abnormal_cardiovascular_devel0.69403714
156MP0001293_anophthalmia0.69234345
157MP0006138_congestive_heart_failure0.67858849
158MP0002697_abnormal_eye_size0.67445175
159MP0002084_abnormal_developmental_patter0.66041375
160MP0004811_abnormal_neuron_physiology0.65791667
161MP0001963_abnormal_hearing_physiology0.64995549
162MP0002115_abnormal_skeleton_extremities0.64855182
163MP0005360_urolithiasis0.64763187
164MP0005595_abnormal_vascular_smooth0.64729623
165MP0002108_abnormal_muscle_morphology0.64504455

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)6.42238472
2Atrophic scars (HP:0001075)5.68515031
3Premature rupture of membranes (HP:0001788)5.50726297
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.24023271
5Protrusio acetabuli (HP:0003179)5.03279129
6Shallow orbits (HP:0000586)4.96540520
7Broad metatarsal (HP:0001783)4.77052916
8Septo-optic dysplasia (HP:0100842)4.56534199
9Fragile nails (HP:0001808)3.88113799
10Milia (HP:0001056)3.80286362
11Split foot (HP:0001839)3.65826599
12Shawl scrotum (HP:0000049)3.62866424
13Ankle contracture (HP:0006466)3.61979252
14Oligodactyly (hands) (HP:0001180)3.61810539
15Turricephaly (HP:0000262)3.57897732
16Fragile skin (HP:0001030)3.54870428
17Onycholysis (HP:0001806)3.46088382
18Gout (HP:0001997)3.32749813
19Cerebral aneurysm (HP:0004944)3.27412034
20Resting tremor (HP:0002322)3.24284615
21Right ventricular cardiomyopathy (HP:0011663)3.15185905
22Bronchomalacia (HP:0002780)3.10717700
23Hemivertebrae (HP:0002937)3.06105804
24Aortic dissection (HP:0002647)3.04885746
25Esophageal atresia (HP:0002032)3.01127165
26Maternal diabetes (HP:0009800)2.95549293
27Coronal craniosynostosis (HP:0004440)2.93371956
28Tachypnea (HP:0002789)2.89454961
29Hypercortisolism (HP:0001578)2.88800860
30Buphthalmos (HP:0000557)2.81188535
31Renal salt wasting (HP:0000127)2.80771018
32Oligodactyly (HP:0012165)2.80378164
33Tubulointerstitial fibrosis (HP:0005576)2.79776721
34Hyperactive renin-angiotensin system (HP:0000841)2.78740020
35Respiratory distress (HP:0002098)2.77083467
36Infantile muscular hypotonia (HP:0008947)2.73890162
37Deep palmar crease (HP:0006191)2.70421411
38Overgrowth (HP:0001548)2.69425987
39Long toe (HP:0010511)2.68301338
40Midline defect of the nose (HP:0004122)2.59681522
41Hyperparathyroidism (HP:0000843)2.56196598
42Mildly elevated creatine phosphokinase (HP:0008180)2.55274837
43Optic nerve hypoplasia (HP:0000609)2.52595865
44Blue sclerae (HP:0000592)2.50557477
45Peritonitis (HP:0002586)2.49934038
46Supernumerary ribs (HP:0005815)2.49033845
47Abnormality of the ischium (HP:0003174)2.47760521
48Bladder diverticulum (HP:0000015)2.47644154
49Down-sloping shoulders (HP:0200021)2.46451400
50Neonatal short-limb short stature (HP:0008921)2.46083785
51Sparse lateral eyebrow (HP:0005338)2.44710974
52Ulnar bowing (HP:0003031)2.44478555
53Supernumerary bones of the axial skeleton (HP:0009144)2.44136275
54Deviation of the hallux (HP:0010051)2.43227666
55Gastrointestinal atresia (HP:0002589)2.42723001
56Volvulus (HP:0002580)2.42403639
57Abnormality of the diencephalon (HP:0010662)2.41620128
58Mitral valve prolapse (HP:0001634)2.40829126
59Partial duplication of thumb phalanx (HP:0009944)2.40590082
60Congenital glaucoma (HP:0001087)2.37663993
61Soft skin (HP:0000977)2.35435889
62Abnormality of the 2nd finger (HP:0004100)2.34733656
63Hallux valgus (HP:0001822)2.30836292
64Aplasia cutis congenita (HP:0001057)2.30216209
65Missing ribs (HP:0000921)2.29062649
66Vertebral arch anomaly (HP:0008438)2.28666958
67Absent frontal sinuses (HP:0002688)2.28441847
68Genu recurvatum (HP:0002816)2.28020666
69Postural instability (HP:0002172)2.27854017
70Absent septum pellucidum (HP:0001331)2.27613836
71Rib fusion (HP:0000902)2.26935316
72Pili torti (HP:0003777)2.25257457
73Aortic aneurysm (HP:0004942)2.23822359
74Anophthalmia (HP:0000528)2.23722045
75Spinal rigidity (HP:0003306)2.20751233
76Wide anterior fontanel (HP:0000260)2.20495139
77Aplasia involving bones of the extremities (HP:0009825)2.18691917
78Aplasia involving bones of the upper limbs (HP:0009823)2.18691917
79Aplasia of the phalanges of the hand (HP:0009802)2.18691917
80Nephronophthisis (HP:0000090)2.15625170
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14475555
82Hypoplastic ischia (HP:0003175)2.14218223
83Intestinal atresia (HP:0011100)2.13337513
84Abnormality of the distal phalanges of the toes (HP:0010182)2.12715503
85Dilatation of the ascending aorta (HP:0005111)2.12578199
86Exocrine pancreatic insufficiency (HP:0001738)2.11183173
87Abnormality of the 4th metacarpal (HP:0010012)2.09293157
88Hyperextensible skin (HP:0000974)2.08744994
89Aneurysm (HP:0002617)2.06173360
90Curly hair (HP:0002212)2.05724236
91Hypoplasia of the iris (HP:0007676)2.04442505
92Thin bony cortex (HP:0002753)2.02631824
93Molar tooth sign on MRI (HP:0002419)2.02542941
94Abnormality of midbrain morphology (HP:0002418)2.02542941
95Morphological abnormality of the middle ear (HP:0008609)2.01468123
96Trigonocephaly (HP:0000243)1.98407760
97Abnormality of the parietal bone (HP:0002696)1.96358493
98Short 4th metacarpal (HP:0010044)1.95678151
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95678151
100Increased connective tissue (HP:0009025)1.94551017
101Abnormality of chloride homeostasis (HP:0011422)1.94530672
102Tubular atrophy (HP:0000092)1.94441218
103Abnormality of dentin (HP:0010299)1.93803010
104Abnormal hemoglobin (HP:0011902)1.93505000
105Vertebral clefting (HP:0008428)1.90039925
106Hypokalemic alkalosis (HP:0001949)1.89749174
107Exotropia (HP:0000577)1.89422166
108Myelomeningocele (HP:0002475)1.89259757
109Hypercalcemia (HP:0003072)1.89234258
110Arnold-Chiari malformation (HP:0002308)1.89019955
111Renal hypoplasia (HP:0000089)1.87792707
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.86414742
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85811662
114Abnormality of the renal medulla (HP:0100957)1.85120831
115Obstructive sleep apnea (HP:0002870)1.85062960
116Morphological abnormality of the inner ear (HP:0011390)1.84622054
117Abnormality of the incisor (HP:0000676)1.83580650
118Osteopenia (HP:0000938)1.81723102
119Bowed forearm bones (HP:0003956)1.80845596
120Bowing of the arm (HP:0006488)1.80845596
121Type 1 muscle fiber predominance (HP:0003803)1.80305514
122Mitral regurgitation (HP:0001653)1.78909928
123Hypoplasia of dental enamel (HP:0006297)1.78808186
124Ulnar claw (HP:0001178)1.78121946
125Cutaneous finger syndactyly (HP:0010554)1.78018090
126Broad distal phalanx of finger (HP:0009836)1.77802455
127Lymphangioma (HP:0100764)1.76950353
128Abnormality of the septum pellucidum (HP:0007375)1.76908759
129Concave nail (HP:0001598)1.76704061
130Hip dysplasia (HP:0001385)1.76015375
131Follicular hyperkeratosis (HP:0007502)1.75170622
132Preauricular skin tag (HP:0000384)1.74515884
133Humeroradial synostosis (HP:0003041)1.74354738
134Synostosis involving the elbow (HP:0003938)1.74354738
135Elbow flexion contracture (HP:0002987)1.73731034
136Glomerulosclerosis (HP:0000096)1.73088965
137Abnormality of the middle phalanges of the toes (HP:0010183)1.72661836
138Tubulointerstitial nephritis (HP:0001970)1.72256105
139Severe Myopia (HP:0011003)1.71716944
140Forearm undergrowth (HP:0009821)1.71591783
141Renal duplication (HP:0000075)1.70969801
142Choanal stenosis (HP:0000452)1.70616704
143Tibial bowing (HP:0002982)1.70110007
144Woolly hair (HP:0002224)1.69767351
145Medial flaring of the eyebrow (HP:0010747)1.69699022
146Partial duplication of the phalanx of hand (HP:0009999)1.69512227
147Cervical subluxation (HP:0003308)1.69327249
148Labial hypoplasia (HP:0000066)1.69157300
149Hypochromic microcytic anemia (HP:0004840)1.68044949
150Neonatal respiratory distress (HP:0002643)1.67953238
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67856730
152Multiple lipomas (HP:0001012)1.67669178
153Congenital malformation of the right heart (HP:0011723)1.67524666
154Double outlet right ventricle (HP:0001719)1.67524666
155Skin tags (HP:0010609)1.67491318
156Meningocele (HP:0002435)1.66553962
157Broad long bones (HP:0005622)1.66514522
158Cystic liver disease (HP:0006706)1.66313404
159Bell-shaped thorax (HP:0001591)1.66184724
160True hermaphroditism (HP:0010459)1.66109443
161Megalencephaly (HP:0001355)1.66035558
162Atelectasis (HP:0100750)1.65674251
163Plantar hyperkeratosis (HP:0007556)1.65526543
164Nuclear cataract (HP:0100018)1.65463837
165Hypoplasia of the radius (HP:0002984)1.65243402
166Abnormality of renal excretion (HP:0011036)1.63700829
167Wormian bones (HP:0002645)1.63481135
168Broad thumb (HP:0011304)1.63456595
169Germ cell neoplasia (HP:0100728)1.63114444
170Femoral bowing (HP:0002980)1.62931298
171Microtia (HP:0008551)1.62542609
172Gait imbalance (HP:0002141)1.61671226
173Advanced eruption of teeth (HP:0006288)1.60729901
174Enlarged penis (HP:0000040)1.59742054
175Abnormality of purine metabolism (HP:0004352)1.59490846
176Abnormality of the anterior chamber (HP:0000593)1.59226016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM26.16378440
2BMPR1B5.05490697
3SIK14.48711407
4TRIB33.95993862
5STK243.41358904
6CASK3.29018750
7TGFBR13.07177855
8EPHA22.97611292
9EPHB12.80415212
10STK38L2.78603790
11PNCK2.78117769
12FER2.70621341
13LATS12.60502620
14EPHA32.58662228
15NTRK22.52819949
16CDK82.52237604
17PKN22.51384934
18MOS2.45132578
19ERN12.42876340
20RIPK12.19390811
21EPHB22.14568596
22WNK42.09643003
23FGFR22.04869317
24PDGFRA1.99631776
25PTK61.99293961
26LRRK21.90660842
27DDR21.88574222
28MARK11.83407350
29LATS21.79210518
30TYRO31.75234130
31TNIK1.74703502
32BMX1.62970922
33PDGFRB1.60972821
34PAK61.53652636
35STK161.52534443
36NME21.52218392
37PAK41.51843138
38FGFR41.46290336
39CAMK1D1.45919041
40BCR1.44240305
41TTN1.40317667
42PTK21.35520253
43CAMK1G1.33111913
44PRKD21.29361618
45MATK1.28371837
46ILK1.27670172
47SIK21.26006912
48NTRK31.23606119
49CAMK2B1.17498071
50CAMK2D1.15859310
51EEF2K1.14768790
52DYRK1B1.10275086
53STK31.09544328
54RET1.09036359
55TGFBR21.08654674
56WNK31.08125606
57TAOK31.07702415
58ERBB21.07026395
59UHMK11.06443149
60DYRK21.04229420
61MAP2K71.02600489
62CDK91.02446044
63TAF10.99208510
64MST1R0.98653818
65LMTK20.96285592
66DMPK0.96028668
67PIM10.95520203
68STK390.93616374
69EIF2AK30.91197436
70CDK60.89553129
71MET0.89508273
72FGFR10.88402820
73MAP3K40.87545090
74PRKD10.86839523
75PAK20.83309677
76ZAP700.82757254
77MAP3K90.82527989
78GSK3A0.82504065
79PIK3CA0.82106088
80PRKCH0.81503438
81MAP3K50.81278218
82MAPK150.81032555
83MAP3K20.80234516
84CAMK2G0.79997480
85NEK20.77123160
86WNK10.75689398
87PDK20.75458883
88DAPK20.72626299
89ABL20.71186431
90RPS6KA60.70699341
91MAP3K70.65411025
92MAP3K100.62485735
93MTOR0.61881979
94PAK30.60219610
95YES10.58960813
96BCKDK0.58588673
97DAPK30.57391841
98PIK3CG0.55914710
99FGFR30.55221551
100MAP3K30.54468988
101HIPK20.52262359
102TSSK60.52169953
103PRKCG0.51887489
104NLK0.50085564
105ICK0.50061167
106CSNK1G20.48802962
107IRAK10.47118537
108STK380.45671770
109INSRR0.44812681
110CDK140.44668423
111TAOK10.44651492
112NEK90.44253548
113CDC42BPA0.43952306
114CDK50.43773213
115ROCK10.43718549
116MARK20.43474575
117WEE10.42608714
118RPS6KA20.41952771
119MAP2K20.41502922
120MAPK40.40704271
121CDK70.40401537
122CAMK2A0.40205741
123CSNK1A1L0.37414968
124TESK10.36796985
125AKT10.36737724
126STK100.35713120
127NTRK10.35692094
128EGFR0.34241464
129ARAF0.34031119
130CSNK1G10.33124061
131MAP3K10.32999098
132PKN10.32989401
133MST40.32538437
134PRKD30.31783133
135PINK10.31207791
136PTK2B0.30317508
137SRC0.29955597
138LIMK10.29391600
139ALK0.29155050
140INSR0.27926387
141RPS6KL10.27144107
142RPS6KC10.27144107
143CAMK10.26910189
144CAMKK10.26360933
145MAP2K10.25870646
146CHUK0.25797409
147MYLK0.24361032
148MAPK140.24302176
149CSNK1E0.22900367
150ABL10.22416800
151PRKAA20.21747348
152RPS6KA40.21254648
153ROCK20.21123736
154GSK3B0.21108739
155OXSR10.20967286
156KSR10.20694733
157MAPK10.20147078
158RPS6KA10.19633439

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.42313817
2Nicotine addiction_Homo sapiens_hsa050332.96122254
3Sulfur relay system_Homo sapiens_hsa041222.80559164
4Bladder cancer_Homo sapiens_hsa052192.78202817
5Basal cell carcinoma_Homo sapiens_hsa052172.49343837
6Fatty acid biosynthesis_Homo sapiens_hsa000612.46258942
7Adherens junction_Homo sapiens_hsa045202.40739098
8Focal adhesion_Homo sapiens_hsa045102.33778877
9Caffeine metabolism_Homo sapiens_hsa002322.17820532
10Hippo signaling pathway_Homo sapiens_hsa043902.04665996
11Proteoglycans in cancer_Homo sapiens_hsa052051.95424632
12Protein digestion and absorption_Homo sapiens_hsa049741.86877515
13Amoebiasis_Homo sapiens_hsa051461.86037670
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84122460
15Hedgehog signaling pathway_Homo sapiens_hsa043401.82838398
16Small cell lung cancer_Homo sapiens_hsa052221.82561310
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81796241
18Ribosome_Homo sapiens_hsa030101.78241644
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72677362
20Tight junction_Homo sapiens_hsa045301.71755939
21Circadian rhythm_Homo sapiens_hsa047101.67999867
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57608577
23Chronic myeloid leukemia_Homo sapiens_hsa052201.54766755
24Endometrial cancer_Homo sapiens_hsa052131.54151513
25Cholinergic synapse_Homo sapiens_hsa047251.46355269
26Pancreatic cancer_Homo sapiens_hsa052121.44870053
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40084409
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36176660
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33730449
30Basal transcription factors_Homo sapiens_hsa030221.29625578
31Mineral absorption_Homo sapiens_hsa049781.27897904
32Melanoma_Homo sapiens_hsa052181.27301037
33Nitrogen metabolism_Homo sapiens_hsa009101.26920488
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.26835536
35Renal cell carcinoma_Homo sapiens_hsa052111.26805754
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26039011
37Dilated cardiomyopathy_Homo sapiens_hsa054141.25214838
38MicroRNAs in cancer_Homo sapiens_hsa052061.24702593
39Axon guidance_Homo sapiens_hsa043601.23033580
40Pathways in cancer_Homo sapiens_hsa052001.20942672
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.20814312
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19823411
43Thyroid cancer_Homo sapiens_hsa052161.18923173
44Notch signaling pathway_Homo sapiens_hsa043301.18901895
45Acute myeloid leukemia_Homo sapiens_hsa052211.18074913
46Melanogenesis_Homo sapiens_hsa049161.17877034
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15737882
48Prostate cancer_Homo sapiens_hsa052151.13614205
49Wnt signaling pathway_Homo sapiens_hsa043101.13496722
50Glutamatergic synapse_Homo sapiens_hsa047241.12246280
51Circadian entrainment_Homo sapiens_hsa047131.11252732
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09850121
53Fatty acid degradation_Homo sapiens_hsa000711.08916510
54Prolactin signaling pathway_Homo sapiens_hsa049171.08908747
55Fatty acid metabolism_Homo sapiens_hsa012121.08872315
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06284467
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04510929
58Glioma_Homo sapiens_hsa052141.04450649
59TGF-beta signaling pathway_Homo sapiens_hsa043501.03540527
60Insulin resistance_Homo sapiens_hsa049311.01278320
61Prion diseases_Homo sapiens_hsa050200.97811587
62Non-small cell lung cancer_Homo sapiens_hsa052230.95478886
63AMPK signaling pathway_Homo sapiens_hsa041520.94561358
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93863890
65Malaria_Homo sapiens_hsa051440.93528548
66Rap1 signaling pathway_Homo sapiens_hsa040150.93453009
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92269145
68Morphine addiction_Homo sapiens_hsa050320.92017814
69Oxytocin signaling pathway_Homo sapiens_hsa049210.91007553
70Cocaine addiction_Homo sapiens_hsa050300.90245769
71GABAergic synapse_Homo sapiens_hsa047270.90220539
72p53 signaling pathway_Homo sapiens_hsa041150.89341792
73Vibrio cholerae infection_Homo sapiens_hsa051100.87925365
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87284044
75Toxoplasmosis_Homo sapiens_hsa051450.86045355
76ErbB signaling pathway_Homo sapiens_hsa040120.85824671
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84457319
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83100954
79PPAR signaling pathway_Homo sapiens_hsa033200.82290379
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.82149563
81Long-term depression_Homo sapiens_hsa047300.81834236
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.80521538
83Lysine degradation_Homo sapiens_hsa003100.79641801
84cAMP signaling pathway_Homo sapiens_hsa040240.78194678
85VEGF signaling pathway_Homo sapiens_hsa043700.77729396
86Lysosome_Homo sapiens_hsa041420.77182820
87FoxO signaling pathway_Homo sapiens_hsa040680.76654399
88MAPK signaling pathway_Homo sapiens_hsa040100.76349462
89Insulin signaling pathway_Homo sapiens_hsa049100.75224381
90Colorectal cancer_Homo sapiens_hsa052100.74595440
91Endocytosis_Homo sapiens_hsa041440.72626911
92Cardiac muscle contraction_Homo sapiens_hsa042600.72344168
93Insulin secretion_Homo sapiens_hsa049110.70444516
94HTLV-I infection_Homo sapiens_hsa051660.70430455
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69884915
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69513712
97Estrogen signaling pathway_Homo sapiens_hsa049150.68648714
98Phototransduction_Homo sapiens_hsa047440.68331507
99Platelet activation_Homo sapiens_hsa046110.68204654
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65542951
101Cell cycle_Homo sapiens_hsa041100.65419390
102Dopaminergic synapse_Homo sapiens_hsa047280.64913299
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64662371
104RNA degradation_Homo sapiens_hsa030180.63786091
105Phagosome_Homo sapiens_hsa041450.61521583
106Taste transduction_Homo sapiens_hsa047420.61484821
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60767419
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60506674
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60475137
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60437584
111Steroid biosynthesis_Homo sapiens_hsa001000.59634736
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58932866
113Viral myocarditis_Homo sapiens_hsa054160.58352457
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.58281664
115Gastric acid secretion_Homo sapiens_hsa049710.56207249
116Collecting duct acid secretion_Homo sapiens_hsa049660.55996535
117Hepatitis C_Homo sapiens_hsa051600.54132821
118Renin-angiotensin system_Homo sapiens_hsa046140.53882743
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53870603
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50914595
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45052105
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44893526
123Type II diabetes mellitus_Homo sapiens_hsa049300.44873169
124Bile secretion_Homo sapiens_hsa049760.44714942
125Dorso-ventral axis formation_Homo sapiens_hsa043200.44688343
126HIF-1 signaling pathway_Homo sapiens_hsa040660.44140538
127Propanoate metabolism_Homo sapiens_hsa006400.43489345
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.43059953
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42905923
130GnRH signaling pathway_Homo sapiens_hsa049120.42055227
131Calcium signaling pathway_Homo sapiens_hsa040200.42044907
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39513051
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39233341
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.39202943
135Gap junction_Homo sapiens_hsa045400.38066914
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.37080007
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37010315
138TNF signaling pathway_Homo sapiens_hsa046680.36676457
139mTOR signaling pathway_Homo sapiens_hsa041500.36092637
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35726825
141Salmonella infection_Homo sapiens_hsa051320.35357888
142Ras signaling pathway_Homo sapiens_hsa040140.35196744
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35138163
144Choline metabolism in cancer_Homo sapiens_hsa052310.35128115

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