IRX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.50451544
2desmosome organization (GO:0002934)7.07042875
3* pattern specification involved in kidney development (GO:0061004)6.43381003
4surfactant homeostasis (GO:0043129)5.39834344
5molting cycle (GO:0042303)5.25538497
6hair cycle (GO:0042633)5.25538497
7ectoderm development (GO:0007398)5.11017933
8chemical homeostasis within a tissue (GO:0048875)4.49753202
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.38783670
10neuronal stem cell maintenance (GO:0097150)4.23518884
11regulation of water loss via skin (GO:0033561)4.18610215
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.16999084
13polarized epithelial cell differentiation (GO:0030859)4.04077181
14otic vesicle formation (GO:0030916)4.02064257
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00573482
16tooth mineralization (GO:0034505)4.00486509
17mammary gland epithelial cell differentiation (GO:0060644)4.00452073
18negative regulation of cell fate specification (GO:0009996)3.97468845
19establishment of skin barrier (GO:0061436)3.93528417
20negative regulation of fatty acid transport (GO:2000192)3.92924122
21* segment specification (GO:0007379)3.89120536
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88404074
23limb bud formation (GO:0060174)3.86436493
24skin morphogenesis (GO:0043589)3.86047833
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.85847151
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85421015
27cranial nerve development (GO:0021545)3.83223670
28cellular response to vitamin D (GO:0071305)3.80985748
29keratinocyte development (GO:0003334)3.77820244
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.76998476
31Golgi transport vesicle coating (GO:0048200)3.73318874
32COPI coating of Golgi vesicle (GO:0048205)3.73318874
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66060773
34negative regulation of keratinocyte proliferation (GO:0010839)3.62222517
35neuron fate determination (GO:0048664)3.60909839
36positive regulation of p38MAPK cascade (GO:1900745)3.60270323
37establishment of apical/basal cell polarity (GO:0035089)3.56973070
38epithelial cell-cell adhesion (GO:0090136)3.55585148
39regulation of cell fate specification (GO:0042659)3.50481711
40axon ensheathment in central nervous system (GO:0032291)3.50063369
41central nervous system myelination (GO:0022010)3.50063369
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.50062212
43presynaptic membrane assembly (GO:0097105)3.45743562
44oligosaccharide biosynthetic process (GO:0009312)3.45733548
45long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.41343208
46cell-substrate junction assembly (GO:0007044)3.40291395
47establishment of tissue polarity (GO:0007164)3.39465150
48establishment of planar polarity (GO:0001736)3.39465150
49multicellular organismal water homeostasis (GO:0050891)3.37832062
50regulation of p38MAPK cascade (GO:1900744)3.36844259
51negative regulation of oligodendrocyte differentiation (GO:0048715)3.34558689
52fatty-acyl-CoA biosynthetic process (GO:0046949)3.30561283
53lactation (GO:0007595)3.30282375
54positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.26473349
55presynaptic membrane organization (GO:0097090)3.26033457
56nephron epithelium morphogenesis (GO:0072088)3.22291083
57nephron tubule morphogenesis (GO:0072078)3.22291083
58protein heterotrimerization (GO:0070208)3.21132669
59regulation of apoptotic process involved in morphogenesis (GO:1902337)3.20374300
60cellular response to vitamin (GO:0071295)3.20011804
61dorsal/ventral axis specification (GO:0009950)3.19872827
62keratinocyte differentiation (GO:0030216)3.19532165
63cell-cell signaling involved in cell fate commitment (GO:0045168)3.17516515
64paraxial mesoderm development (GO:0048339)3.17288725
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.16906916
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16762386
67growth hormone receptor signaling pathway (GO:0060396)3.14036807
68type B pancreatic cell proliferation (GO:0044342)3.12847264
69negative regulation of catenin import into nucleus (GO:0035414)3.11287519
70axonal fasciculation (GO:0007413)3.07809306
71regulation of cardioblast differentiation (GO:0051890)3.06500242
72notochord development (GO:0030903)3.06482277
73retinal ganglion cell axon guidance (GO:0031290)3.04085293
74gland morphogenesis (GO:0022612)3.03579359
75secretion by tissue (GO:0032941)3.00779892
76thioester biosynthetic process (GO:0035384)3.00188757
77acyl-CoA biosynthetic process (GO:0071616)3.00188757
78nonmotile primary cilium assembly (GO:0035058)2.99626562
79adhesion of symbiont to host cell (GO:0044650)2.99117685
80virion attachment to host cell (GO:0019062)2.99117685
81kidney morphogenesis (GO:0060993)2.99065953
82establishment or maintenance of monopolar cell polarity (GO:0061339)2.97394051
83establishment of monopolar cell polarity (GO:0061162)2.97394051
84keratinization (GO:0031424)2.96960670
85embryonic process involved in female pregnancy (GO:0060136)2.96070148
86epithelial cilium movement (GO:0003351)2.95257043
87hippo signaling (GO:0035329)2.93756573
88negative regulation of cell fate commitment (GO:0010454)2.93598084
89regulation of hippo signaling (GO:0035330)2.90873752
90mesenchymal to epithelial transition (GO:0060231)2.86007186
91developmental induction (GO:0031128)2.85818806
92forebrain neuron differentiation (GO:0021879)2.85739978
93lung-associated mesenchyme development (GO:0060484)2.85124734
94limb development (GO:0060173)2.84547901
95appendage development (GO:0048736)2.84547901
96tongue development (GO:0043586)2.83167509
97behavioral response to nicotine (GO:0035095)2.82624416
98adhesion of symbiont to host (GO:0044406)2.80735031
99nodal signaling pathway (GO:0038092)2.79536880
100lens fiber cell development (GO:0070307)2.78321772
101dendritic spine morphogenesis (GO:0060997)2.76956226
102non-canonical Wnt signaling pathway (GO:0035567)2.76863666
103midbrain development (GO:0030901)2.76545988
104positive regulation of histone deacetylation (GO:0031065)2.76283346
105wound healing, spreading of epidermal cells (GO:0035313)2.76237754
106cilium movement (GO:0003341)2.75577160
107negative regulation of smooth muscle cell migration (GO:0014912)2.75316128
108atrioventricular valve morphogenesis (GO:0003181)2.75182407
109endodermal cell differentiation (GO:0035987)2.74648160
110decidualization (GO:0046697)2.73942510
111renal system development (GO:0072001)2.71381185
112auditory receptor cell differentiation (GO:0042491)2.71225105
113ectodermal placode formation (GO:0060788)2.70043677
114epidermal cell differentiation (GO:0009913)2.68538728
115mesodermal cell differentiation (GO:0048333)2.67219286
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.66748632
117water homeostasis (GO:0030104)2.66276301
118branching involved in salivary gland morphogenesis (GO:0060445)2.66178752
119bone morphogenesis (GO:0060349)2.65238692
120cellular response to growth hormone stimulus (GO:0071378)2.64765452
121negative regulation of chondrocyte differentiation (GO:0032331)2.63793476
122cardiac right ventricle morphogenesis (GO:0003215)2.63426766
123hindbrain development (GO:0030902)2.63161946
124regulation of mesoderm development (GO:2000380)2.62202862
125negative regulation of glial cell differentiation (GO:0045686)2.61882453
126lung lobe morphogenesis (GO:0060463)2.61824582
127Sertoli cell development (GO:0060009)2.61077507
128keratinocyte proliferation (GO:0043616)2.60844750
129cranial suture morphogenesis (GO:0060363)2.59354260
130body fluid secretion (GO:0007589)2.59306001
131apical protein localization (GO:0045176)2.59128006
132endocardial cushion morphogenesis (GO:0003203)2.58793073
133establishment of nucleus localization (GO:0040023)2.58788437
134spinal cord development (GO:0021510)2.57714428
135negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.56718332
136basement membrane organization (GO:0071711)2.56190400
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55811159
138Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55315140
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.55071668
140startle response (GO:0001964)2.54122885
141outer ear morphogenesis (GO:0042473)2.53441356
142long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.53378320
143peptide cross-linking (GO:0018149)2.52520211
144translational termination (GO:0006415)2.51816238
145cochlea development (GO:0090102)2.51516128
146lateral sprouting from an epithelium (GO:0060601)2.50983329
147viral transcription (GO:0019083)2.50390889
148neuron fate specification (GO:0048665)2.50206689
149regulation of catenin import into nucleus (GO:0035412)2.49557731
150negative regulation of astrocyte differentiation (GO:0048712)2.48898031
151axonemal dynein complex assembly (GO:0070286)2.48409758
152intermediate filament organization (GO:0045109)2.48372590
153positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47785899
154positive regulation of vascular permeability (GO:0043117)2.47758164
155regulation of establishment of planar polarity (GO:0090175)2.47501345
156somite development (GO:0061053)2.47465382
157epidermis development (GO:0008544)2.47024652
158cell proliferation in forebrain (GO:0021846)2.44978102
159renal tubule morphogenesis (GO:0061333)2.44925407
160somite rostral/caudal axis specification (GO:0032525)2.44750036
161neuron cell-cell adhesion (GO:0007158)2.44266682
162heart valve formation (GO:0003188)2.43740822
163ventricular septum development (GO:0003281)2.42612460
164pituitary gland development (GO:0021983)2.42431980
165epithelial cell fate commitment (GO:0072148)2.39735013
166regulation of gene silencing by RNA (GO:0060966)2.39596965
167regulation of posttranscriptional gene silencing (GO:0060147)2.39596965
168regulation of gene silencing by miRNA (GO:0060964)2.39596965
169negative regulation of axon guidance (GO:1902668)2.39382532
170spinal cord motor neuron differentiation (GO:0021522)2.39345962
171nerve development (GO:0021675)2.38335552
172innervation (GO:0060384)2.37820338
173organ growth (GO:0035265)2.36861295
174smoothened signaling pathway (GO:0007224)2.33548820
175epithelial tube branching involved in lung morphogenesis (GO:0060441)2.32596221
176neuron recognition (GO:0008038)2.30926100
177lens morphogenesis in camera-type eye (GO:0002089)2.30468850
178radial glial cell differentiation (GO:0060019)2.28969281
179detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26867278
180regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.26108448
181nucleobase catabolic process (GO:0046113)2.25326348
182glandular epithelial cell differentiation (GO:0002067)2.24732711
183post-anal tail morphogenesis (GO:0036342)2.24045759
184embryonic axis specification (GO:0000578)2.23627707
185regulation of oligodendrocyte differentiation (GO:0048713)2.23615805
186mechanoreceptor differentiation (GO:0042490)2.22800073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.87873383
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.87655736
3EZH2_22144423_ChIP-Seq_EOC_Human3.32019655
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.31924976
5ZNF263_19887448_ChIP-Seq_K562_Human3.23390364
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.07807031
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03059496
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97704836
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76368468
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62318255
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.56049007
12GBX2_23144817_ChIP-Seq_PC3_Human2.54081641
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53661955
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51006889
15CLOCK_20551151_ChIP-Seq_293T_Human2.43551820
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41774767
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37463588
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28057512
19SOX9_24532713_ChIP-Seq_HFSC_Mouse2.24125161
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20078589
21* CBX2_27304074_Chip-Seq_ESCs_Mouse2.19684614
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10354362
23FUS_26573619_Chip-Seq_HEK293_Human2.10023296
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07816082
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.07283996
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06951131
27* EED_16625203_ChIP-ChIP_MESCs_Mouse1.98593908
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97388513
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97375143
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96592866
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95193842
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92584490
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.91024765
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90661892
35ZNF274_21170338_ChIP-Seq_K562_Hela1.86065520
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.85317570
37TAF15_26573619_Chip-Seq_HEK293_Human1.84911763
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83463104
39VDR_22108803_ChIP-Seq_LS180_Human1.82588997
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.81829903
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80681683
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.78035222
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77982499
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.77502994
45* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77218478
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.73062365
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72079933
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70249232
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68745867
50P300_19829295_ChIP-Seq_ESCs_Human1.67536126
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65833837
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65833837
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64097696
54* SOX2_20726797_ChIP-Seq_SW620_Human1.64031822
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63472247
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62796534
57* RNF2_27304074_Chip-Seq_NSC_Mouse1.62728727
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62386835
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61128198
60* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59818525
61* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59818525
62EWS_26573619_Chip-Seq_HEK293_Human1.58253992
63* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58008610
64* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53787933
65* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52362655
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52124282
67* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49967966
68* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48465096
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47012979
70ATF3_27146783_Chip-Seq_COLON_Human1.46655895
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46521850
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46254354
73* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45387188
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44928401
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44761226
76AHR_22903824_ChIP-Seq_MCF-7_Human1.44252491
77* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44039862
78KLF5_25053715_ChIP-Seq_YYC3_Human1.43370834
79* EZH2_27294783_Chip-Seq_ESCs_Mouse1.42494151
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41598093
81* REST_21632747_ChIP-Seq_MESCs_Mouse1.41513098
82* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40947024
83* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40503782
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40445473
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39945650
86* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39526201
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38373107
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38281274
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37952123
90* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35993967
91KDM2B_26808549_Chip-Seq_K562_Human1.35529888
92CJUN_26792858_Chip-Seq_BT549_Human1.34080621
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32843201
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32467549
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32467549
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30527316
97* SOX2_16153702_ChIP-ChIP_HESCs_Human1.30155541
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29127103
99* UBF1/2_26484160_Chip-Seq_HMECs_Human1.28184574
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28015619
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27236525
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.25669831
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.25101377
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.25101377
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24794746
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.24678866
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24519046
108* GATA4_25053715_ChIP-Seq_YYC3_Human1.24268238
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23631726
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.22512211
111LXR_22292898_ChIP-Seq_THP-1_Human1.22472555
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21006717
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20889585
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.20463728
115SMAD4_21799915_ChIP-Seq_A2780_Human1.20384137
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20293813
117* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20039656
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19465139
119* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19242821
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.18868041
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18852884
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18020972
123AR_25329375_ChIP-Seq_VCAP_Human1.16513140
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15995387
125GATA6_25053715_ChIP-Seq_YYC3_Human1.15433173
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.14490008
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13274382
128* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13040078
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12729406
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12597570
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12256438
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11869668
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11744202
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.11085800
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10771664
136BCAT_22108803_ChIP-Seq_LS180_Human1.10319040
137AR_21572438_ChIP-Seq_LNCaP_Human1.09750053
138* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09392138
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08394637
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08213471
141* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08131334
142TP53_18474530_ChIP-ChIP_U2OS_Human1.07377340
143* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07135461
144TP63_19390658_ChIP-ChIP_HaCaT_Human1.07074091
145* GATA3_24758297_ChIP-Seq_MCF-7_Human1.06357325
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05224894
147RUNX2_22187159_ChIP-Seq_PCA_Human1.05201683
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04723129
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04385132
150TP63_23658742_ChIP-Seq_EP156T_Human1.04337815
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03503168
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02867701
153* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01937120
154RXR_22108803_ChIP-Seq_LS180_Human1.01825753
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01182770
156* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01130115
157CREB1_26743006_Chip-Seq_LNCaP_Human1.01065478
158KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00931795
159CHD1_26751641_Chip-Seq_LNCaP_Human1.00838659
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00581739
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99449036
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.99030843
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.98563035
164BRD4_25478319_ChIP-Seq_HGPS_Human0.98281506
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97214967
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97171074
167CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97045406
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96504721
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96407760
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.95720542
171FLI1_27457419_Chip-Seq_LIVER_Mouse0.95604005
172TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95506287
173SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95209443
174TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94888823
175* TP63_22573176_ChIP-Seq_HFKS_Human0.94692480
176JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93408618
177IGF1R_20145208_ChIP-Seq_DFB_Human0.93353089
178PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92538315
179* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92527017
180KDM2B_26808549_Chip-Seq_DND41_Human0.89802542
181FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87000581
182WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86724563
183TCF4_18268006_ChIP-ChIP_LS174T_Human0.85764716
184ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82035095
185KDM2B_26808549_Chip-Seq_JURKAT_Human0.81937873
186FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81848664
187FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81749440
188SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79697639
189FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79676570
190* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78752603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.81975987
2MP0001881_abnormal_mammary_gland4.42220072
3MP0005275_abnormal_skin_tensile3.99095056
4MP0002796_impaired_skin_barrier3.70207912
5MP0003705_abnormal_hypodermis_morpholog3.61890076
6MP0000579_abnormal_nail_morphology3.13375814
7MP0002098_abnormal_vibrissa_morphology2.89259982
8MP0010678_abnormal_skin_adnexa2.48304180
9MP0002653_abnormal_ependyma_morphology2.46326954
10MP0008438_abnormal_cutaneous_collagen2.45537336
11MP0009780_abnormal_chondrocyte_physiolo2.43821467
12MP0002060_abnormal_skin_morphology2.39631843
13MP0005501_abnormal_skin_physiology2.37166493
14MP0004272_abnormal_basement_membrane2.27026832
15MP0004782_abnormal_surfactant_physiolog2.22166551
16MP0003566_abnormal_cell_adhesion2.18648101
17MP0009379_abnormal_foot_pigmentation2.17494549
18MP0000566_synostosis2.15160481
19MP0002254_reproductive_system_inflammat2.14760184
20MP0001958_emphysema2.11936170
21MP0001849_ear_inflammation2.10299515
22MP0004133_heterotaxia2.08210975
23MP0000778_abnormal_nervous_system2.06643374
24MP0003122_maternal_imprinting2.05546740
25MP0000383_abnormal_hair_follicle1.97867315
26MP0000377_abnormal_hair_follicle1.95942646
27MP0002638_abnormal_pupillary_reflex1.93071225
28MP0000627_abnormal_mammary_gland1.91306964
29MP0003453_abnormal_keratinocyte_physiol1.90912086
30MP0003300_gastrointestinal_ulcer1.85277935
31MP0005377_hearing/vestibular/ear_phenot1.84817549
32MP0003878_abnormal_ear_physiology1.84817549
33MP0001216_abnormal_epidermal_layer1.83269781
34MP0005076_abnormal_cell_differentiation1.79957083
35MP0010030_abnormal_orbit_morphology1.78556341
36MP0000762_abnormal_tongue_morphology1.74734580
37MP0006054_spinal_hemorrhage1.73967293
38MP0000647_abnormal_sebaceous_gland1.72686449
39MP0000631_abnormal_neuroendocrine_gland1.69234858
40MP0006292_abnormal_olfactory_placode1.66438191
41MP0002909_abnormal_adrenal_gland1.63795874
42MP0000537_abnormal_urethra_morphology1.63561899
43MP0002234_abnormal_pharynx_morphology1.63148111
44MP0010352_gastrointestinal_tract_polyps1.63062491
45MP0004264_abnormal_extraembryonic_tissu1.62361188
46MP0000013_abnormal_adipose_tissue1.60717171
47MP0002877_abnormal_melanocyte_morpholog1.59917912
48MP0005083_abnormal_biliary_tract1.57562638
49MP0003890_abnormal_embryonic-extraembry1.56174352
50MP0010771_integument_phenotype1.55157932
51MP0001485_abnormal_pinna_reflex1.54987031
52MP0000003_abnormal_adipose_tissue1.52024172
53MP0002282_abnormal_trachea_morphology1.49748178
54MP0003937_abnormal_limbs/digits/tail_de1.43659513
55MP0009384_cardiac_valve_regurgitation1.43408317
56MP0002837_dystrophic_cardiac_calcinosis1.42299161
57MP0004185_abnormal_adipocyte_glucose1.41398287
58MP0003941_abnormal_skin_development1.41078312
59MP0001293_anophthalmia1.37736037
60MP0003121_genomic_imprinting1.35347256
61MP0000427_abnormal_hair_cycle1.33381858
62MP0001286_abnormal_eye_development1.31765052
63MP0003283_abnormal_digestive_organ1.30613458
64MP0005375_adipose_tissue_phenotype1.30583697
65MP0004270_analgesia1.28955598
66MP0002896_abnormal_bone_mineralization1.28275410
67MP0000467_abnormal_esophagus_morphology1.28097386
68MP0005187_abnormal_penis_morphology1.25768570
69MP0008877_abnormal_DNA_methylation1.24756626
70MP0005257_abnormal_intraocular_pressure1.24755120
71MP0003787_abnormal_imprinting1.24517642
72MP0003938_abnormal_ear_development1.22198373
73MP0000026_abnormal_inner_ear1.20325122
74MP0006072_abnormal_retinal_apoptosis1.20227378
75MP0001243_abnormal_dermal_layer1.19128892
76MP0004142_abnormal_muscle_tone1.17740738
77MP0005023_abnormal_wound_healing1.17060823
78MP0005084_abnormal_gallbladder_morpholo1.16354263
79MP0001984_abnormal_olfaction1.14942163
80MP0000049_abnormal_middle_ear1.14754726
81MP0005379_endocrine/exocrine_gland_phen1.14378204
82MP0000955_abnormal_spinal_cord1.13333163
83MP0005174_abnormal_tail_pigmentation1.13177174
84MP0002928_abnormal_bile_duct1.12825437
85MP0005623_abnormal_meninges_morphology1.09087643
86MP0001529_abnormal_vocalization1.08713688
87MP0002277_abnormal_respiratory_mucosa1.07712583
88MP0003045_fibrosis1.06998002
89MP0002557_abnormal_social/conspecific_i1.06570775
90MP0001944_abnormal_pancreas_morphology1.04904990
91MP0004947_skin_inflammation1.03774775
92MP0004019_abnormal_vitamin_homeostasis1.03603564
93MP0003861_abnormal_nervous_system1.03264535
94MP0003119_abnormal_digestive_system1.01038079
95MP0005248_abnormal_Harderian_gland1.00893098
96MP0000569_abnormal_digit_pigmentation1.00629718
97MP0001177_atelectasis0.98925612
98MP0009053_abnormal_anal_canal0.98791090
99MP0002572_abnormal_emotion/affect_behav0.98272198
100MP0005666_abnormal_adipose_tissue0.97618397
101MP0002111_abnormal_tail_morphology0.96936845
102MP0002249_abnormal_larynx_morphology0.96846720
103MP0009931_abnormal_skin_appearance0.95826108
104MP0000462_abnormal_digestive_system0.95720399
105MP0002184_abnormal_innervation0.95121664
106MP0009046_muscle_twitch0.94724559
107MP0000750_abnormal_muscle_regeneration0.94638724
108MP0002295_abnormal_pulmonary_circulatio0.94538784
109MP0002734_abnormal_mechanical_nocicepti0.94218236
110MP0001346_abnormal_lacrimal_gland0.93945630
111MP0001340_abnormal_eyelid_morphology0.93628509
112MP0002736_abnormal_nociception_after0.93121020
113MP0004381_abnormal_hair_follicle0.92561193
114MP0009745_abnormal_behavioral_response0.92299816
115MP0005646_abnormal_pituitary_gland0.89480758
116MP0001968_abnormal_touch/_nociception0.88242314
117MP0005503_abnormal_tendon_morphology0.87738094
118MP0000534_abnormal_ureter_morphology0.87546151
119MP0002152_abnormal_brain_morphology0.86927873
120MP0003115_abnormal_respiratory_system0.86716718
121MP0005508_abnormal_skeleton_morphology0.86512893
122MP0002168_other_aberrant_phenotype0.85268058
123MP0005171_absent_coat_pigmentation0.84183420
124MP0004859_abnormal_synaptic_plasticity0.83131004
125MP0002116_abnormal_craniofacial_bone0.82921144
126MP0001348_abnormal_lacrimal_gland0.82861435
127MP0001191_abnormal_skin_condition0.82733691
128MP0002272_abnormal_nervous_system0.82694735
129MP0000367_abnormal_coat/_hair0.82353104
130MP0003942_abnormal_urinary_system0.80984869
131MP0005423_abnormal_somatic_nervous0.80428109
132MP0009250_abnormal_appendicular_skeleto0.80258551
133MP0000428_abnormal_craniofacial_morphol0.80253976
134MP0002063_abnormal_learning/memory/cond0.80041262
135MP0004130_abnormal_muscle_cell0.79721015
136MP0005645_abnormal_hypothalamus_physiol0.78379149
137MP0002752_abnormal_somatic_nervous0.77893742
138MP0003755_abnormal_palate_morphology0.77380729
139MP0004858_abnormal_nervous_system0.76762631
140MP0008961_abnormal_basal_metabolism0.76120637
141MP0001486_abnormal_startle_reflex0.75377419
142MP0003136_yellow_coat_color0.73837618
143MP0002882_abnormal_neuron_morphology0.73763214
144MP0002932_abnormal_joint_morphology0.73686039
145MP0005195_abnormal_posterior_eye0.73234054
146MP0002067_abnormal_sensory_capabilities0.72830073
147MP0002133_abnormal_respiratory_system0.72652725
148MP0005388_respiratory_system_phenotype0.72652725
149MP0001851_eye_inflammation0.72108195
150MP0001502_abnormal_circadian_rhythm0.71997315
151MP0001963_abnormal_hearing_physiology0.70924238
152MP0002751_abnormal_autonomic_nervous0.70820594
153MP0003385_abnormal_body_wall0.69747451
154MP0000733_abnormal_muscle_development0.69600599
155MP0002009_preneoplasia0.69330672
156MP0003935_abnormal_craniofacial_develop0.67122634
157MP0003091_abnormal_cell_migration0.66115337
158MP0002233_abnormal_nose_morphology0.65840637
159MP0000432_abnormal_head_morphology0.65183583
160MP0000163_abnormal_cartilage_morphology0.64488042
161MP0001299_abnormal_eye_distance/0.64366194
162MP0003279_aneurysm0.64233727
163MP0000678_abnormal_parathyroid_gland0.63478341
164MP0005220_abnormal_exocrine_pancreas0.62925367
165MP0004885_abnormal_endolymph0.59786998
166MP0002697_abnormal_eye_size0.59525225
167MP0001879_abnormal_lymphatic_vessel0.59170514
168MP0008004_abnormal_stomach_pH0.57017554
169MP0002084_abnormal_developmental_patter0.55956060
170MP0002938_white_spotting0.55788387

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)5.83584486
2Milia (HP:0001056)5.68409008
3Fragile nails (HP:0001808)4.96382878
4Onycholysis (HP:0001806)4.85648272
5Pili torti (HP:0003777)4.72695397
6Septo-optic dysplasia (HP:0100842)4.68352932
7Right ventricular cardiomyopathy (HP:0011663)4.59741111
8Hypotrichosis (HP:0001006)3.94729365
9Interstitial pulmonary disease (HP:0006530)3.89200748
10Esophageal atresia (HP:0002032)3.87329982
11Woolly hair (HP:0002224)3.86977654
12Shallow orbits (HP:0000586)3.71684568
13Gastrointestinal atresia (HP:0002589)3.67744037
14Premature rupture of membranes (HP:0001788)3.58157307
15Fragile skin (HP:0001030)3.51965274
16Plantar hyperkeratosis (HP:0007556)3.50190995
17Intestinal atresia (HP:0011100)3.23533634
18Curly hair (HP:0002212)3.14631203
19Partial duplication of thumb phalanx (HP:0009944)3.00839947
20True hermaphroditism (HP:0010459)2.99535807
21Protrusio acetabuli (HP:0003179)2.94332381
22Turricephaly (HP:0000262)2.91934123
23Hypoplasia of dental enamel (HP:0006297)2.90846784
24Nail dystrophy (HP:0008404)2.90447718
25Anophthalmia (HP:0000528)2.88483587
26Maternal diabetes (HP:0009800)2.87023114
27Rib fusion (HP:0000902)2.84805042
28Overgrowth (HP:0001548)2.82121554
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.81977223
30Abnormal hair laboratory examination (HP:0003328)2.80587975
31Gout (HP:0001997)2.79859539
32Thin bony cortex (HP:0002753)2.76254965
33Absent septum pellucidum (HP:0001331)2.75548248
34Optic nerve hypoplasia (HP:0000609)2.72958199
35Cerebral aneurysm (HP:0004944)2.71736957
36Bronchomalacia (HP:0002780)2.69287751
37Ankle contracture (HP:0006466)2.66551943
38Amelogenesis imperfecta (HP:0000705)2.65106940
39Partial duplication of the phalanx of hand (HP:0009999)2.63522577
40Nephronophthisis (HP:0000090)2.62648691
41Broad metatarsal (HP:0001783)2.62648205
42Oligodactyly (hands) (HP:0001180)2.57719335
43Abnormality of nail color (HP:0100643)2.55307695
44Pancreatic fibrosis (HP:0100732)2.51726368
45Congenital ichthyosiform erythroderma (HP:0007431)2.50483147
46Down-sloping shoulders (HP:0200021)2.49725910
47Advanced eruption of teeth (HP:0006288)2.49183863
48Abnormality of the diencephalon (HP:0010662)2.48834435
49Split foot (HP:0001839)2.48439020
50Aplasia cutis congenita (HP:0001057)2.47587599
51Hemivertebrae (HP:0002937)2.40794460
52Long toe (HP:0010511)2.40735925
53Alopecia of scalp (HP:0002293)2.40634948
54Buphthalmos (HP:0000557)2.38312975
55Molar tooth sign on MRI (HP:0002419)2.36812863
56Abnormality of midbrain morphology (HP:0002418)2.36812863
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35997054
58Mildly elevated creatine phosphokinase (HP:0008180)2.33330967
59Pancreatic cysts (HP:0001737)2.31149399
60Labial hypoplasia (HP:0000066)2.30669421
61Abnormality of the dental root (HP:0006486)2.27788085
62Taurodontia (HP:0000679)2.27788085
63Abnormality of permanent molar morphology (HP:0011071)2.27788085
64Natal tooth (HP:0000695)2.27579631
65Bilateral microphthalmos (HP:0007633)2.27315548
66Abnormality of the septum pellucidum (HP:0007375)2.26220327
67Follicular hyperkeratosis (HP:0007502)2.26075425
68Hypoplastic labia majora (HP:0000059)2.21576419
69Abnormality of the renal medulla (HP:0100957)2.20912543
70Abnormality of calcium-phosphate metabolism (HP:0100530)2.20667498
71Abnormality of the labia minora (HP:0012880)2.19327169
72Hypoplastic female external genitalia (HP:0012815)2.17204024
73Sparse lateral eyebrow (HP:0005338)2.16702905
74Aqueductal stenosis (HP:0002410)2.15006112
75Palmoplantar hyperkeratosis (HP:0000972)2.14023528
76Increased connective tissue (HP:0009025)2.13552035
77Abnormality of molar (HP:0011077)2.13428845
78Abnormality of molar morphology (HP:0011070)2.13428845
79Aplasia involving bones of the upper limbs (HP:0009823)2.12763149
80Aplasia of the phalanges of the hand (HP:0009802)2.12763149
81Aplasia involving bones of the extremities (HP:0009825)2.12763149
82Ankyloglossia (HP:0010296)2.11964259
83Megalencephaly (HP:0001355)2.10449725
84Aortic dissection (HP:0002647)2.09028418
85Abnormal blistering of the skin (HP:0008066)2.08828044
86Supernumerary bones of the axial skeleton (HP:0009144)2.06386652
87Thick nail (HP:0001805)2.05139471
88Medial flaring of the eyebrow (HP:0010747)2.04895432
89Abnormality of the middle phalanges of the toes (HP:0010183)2.04705886
90Genital tract atresia (HP:0001827)2.03439765
91Vaginal atresia (HP:0000148)2.03323949
92Abnormal sex determination (HP:0012244)2.02015830
93Sex reversal (HP:0012245)2.02015830
94Midline defect of the nose (HP:0004122)2.01638161
95Coronal craniosynostosis (HP:0004440)2.01494376
96Congenital glaucoma (HP:0001087)2.01275022
97Enlarged penis (HP:0000040)2.01007265
98Supernumerary ribs (HP:0005815)1.99869567
99Palmar hyperkeratosis (HP:0010765)1.99369344
100Hemiparesis (HP:0001269)1.97829803
101Preaxial foot polydactyly (HP:0001841)1.97704476
102Tubulointerstitial fibrosis (HP:0005576)1.96317647
103Abnormality of the labia majora (HP:0012881)1.95630892
104Type 1 muscle fiber predominance (HP:0003803)1.95594840
105Abnormality of the distal phalanges of the toes (HP:0010182)1.95074434
106Acanthosis nigricans (HP:0000956)1.94768415
107Abnormal number of incisors (HP:0011064)1.94669815
108Oligodactyly (HP:0012165)1.94400335
109Renal salt wasting (HP:0000127)1.92375529
110Sclerocornea (HP:0000647)1.92193514
111Abnormal respiratory epithelium morphology (HP:0012253)1.91434966
112Abnormal respiratory motile cilium morphology (HP:0005938)1.91434966
113Abnormal ciliary motility (HP:0012262)1.90855476
114Neonatal short-limb short stature (HP:0008921)1.89207439
115Gait imbalance (HP:0002141)1.88701161
116Tubular atrophy (HP:0000092)1.88160694
117Hyperparathyroidism (HP:0000843)1.87541679
118Vertebral hypoplasia (HP:0008417)1.86982125
119Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86982125
120Cutaneous finger syndactyly (HP:0010554)1.86487461
121Deviation of the hallux (HP:0010051)1.84787313
122Selective tooth agenesis (HP:0001592)1.84709309
123Stenosis of the external auditory canal (HP:0000402)1.84288170
124Glomerulosclerosis (HP:0000096)1.82983568
125Short hallux (HP:0010109)1.82635654
126Increased IgE level (HP:0003212)1.82245445
127Abnormal respiratory motile cilium physiology (HP:0012261)1.82167803
128Lip pit (HP:0100267)1.81943390
129Progressive cerebellar ataxia (HP:0002073)1.81915385
130Mitral valve prolapse (HP:0001634)1.81252194
131Pterygium (HP:0001059)1.81008803
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80923705
133Absent/shortened dynein arms (HP:0200106)1.80644295
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.80644295
135Peritonitis (HP:0002586)1.80457281
136Aortic aneurysm (HP:0004942)1.79511327
137Hypoplasia of the ulna (HP:0003022)1.79284827
138Abnormality of the parietal bone (HP:0002696)1.79179641
139Large for gestational age (HP:0001520)1.79059758
140Germ cell neoplasia (HP:0100728)1.78990974
141Congenital primary aphakia (HP:0007707)1.78267576
142Bladder diverticulum (HP:0000015)1.77666390
143Hypoplasia of the iris (HP:0007676)1.77131155
144Aneurysm (HP:0002617)1.76926279
145Absent eyelashes (HP:0000561)1.76645439
146Spinal rigidity (HP:0003306)1.76256052
147Hallux valgus (HP:0001822)1.75495113
148Corneal erosion (HP:0200020)1.75126263
149Furrowed tongue (HP:0000221)1.73735004
150Abnormality of the gastric mucosa (HP:0004295)1.73609276
151Scrotal hypoplasia (HP:0000046)1.73508189
152Blepharitis (HP:0000498)1.72946221
1532-3 toe syndactyly (HP:0004691)1.72923492
154Aplasia/Hypoplasia of the hallux (HP:0008362)1.71912597
155Humeroradial synostosis (HP:0003041)1.71882354
156Synostosis involving the elbow (HP:0003938)1.71882354
157Morphological abnormality of the middle ear (HP:0008609)1.71000941
158Dilatation of the ascending aorta (HP:0005111)1.70588197
159Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70516754
160Missing ribs (HP:0000921)1.69616757
161Abnormality of the dental pulp (HP:0006479)1.69019624
162Congenital, generalized hypertrichosis (HP:0004540)1.68501971
163Abdominal situs inversus (HP:0003363)1.68441870
164Abnormality of abdominal situs (HP:0011620)1.68441870
165Fibular hypoplasia (HP:0003038)1.68431103
166Abnormality of oral frenula (HP:0000190)1.68004434
167Tibial bowing (HP:0002982)1.67928376
168Short 4th metacarpal (HP:0010044)1.67479862
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67479862
170Cystic liver disease (HP:0006706)1.66516462
171Abnormality of renal excretion (HP:0011036)1.66203270
172Blue sclerae (HP:0000592)1.66040377
173Hyperextensible skin (HP:0000974)1.65857292
174Concave nail (HP:0001598)1.65628762
175Ventricular tachycardia (HP:0004756)1.65289805
176Abnormality of the 2nd finger (HP:0004100)1.64952008
177Subcapsular cataract (HP:0000523)1.64869316
178Conjunctival hamartoma (HP:0100780)1.63708743
179Subacute progressive viral hepatitis (HP:0006572)1.62115834
180Tachypnea (HP:0002789)1.61772756
181Choanal stenosis (HP:0000452)1.61153723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.48976184
2SIK14.64994621
3TRIB34.10810143
4CASK3.81925592
5EPHA23.65763215
6PKN23.05751348
7TNIK2.99572483
8LATS12.94937486
9FER2.94209633
10ERN12.91004628
11WNK32.48993047
12CAMK1D2.46640456
13MAP3K92.39610276
14WNK42.37495078
15EPHA32.30340826
16EPHB12.30286584
17PTK62.27884727
18NTRK22.17261814
19WEE12.15750649
20EEF2K2.12923044
21EPHB22.01197987
22RIPK11.94654026
23CAMK1G1.92355453
24TSSK61.86705086
25MAPK151.81009318
26LRRK21.80904242
27MAPKAPK31.71713290
28MAP3K21.60145454
29DDR21.57221469
30PIK3CG1.56332220
31MKNK21.56177963
32VRK11.55495833
33FGFR21.55394096
34PDGFRA1.52909493
35PINK11.52861839
36PTK21.44247695
37GRK11.42353663
38BMPR1B1.41136717
39BMX1.38485383
40PDGFRB1.37074762
41MAP3K41.35942043
42MAP3K31.35647116
43MARK11.32125180
44DYRK21.30316539
45LATS21.29209986
46FGFR41.24360874
47TGFBR11.19803622
48ADRBK21.19656606
49PHKG21.18632714
50PHKG11.18632714
51MST1R1.16741855
52TTN1.16512580
53DYRK1B1.14656499
54RPS6KB21.13924578
55PIK3CA1.10264105
56NME21.06910524
57PAK41.06421793
58PRKCG1.05934174
59STK38L1.05094782
60ILK1.04098493
61MATK1.03801666
62NTRK11.01639825
63CDK61.01279910
64MET0.99717013
65CDK30.98854642
66RET0.98429632
67MAP2K40.98395844
68TGFBR20.98344536
69STK240.98255954
70FRK0.97954366
71NEK20.95824734
72FGFR10.93804194
73WNK10.92138235
74MTOR0.89231436
75PLK30.88455930
76BCR0.88170533
77NTRK30.86593860
78MKNK10.81549305
79MAP2K70.81046169
80TRPM70.79878964
81STK160.79569067
82ERBB20.79436139
83CSNK1G20.79419313
84YES10.78918463
85TAF10.78659768
86HIPK20.78313080
87STK390.77465424
88MST40.76192040
89TESK10.75611864
90STK30.74137069
91PAK30.72630437
92MAP3K120.72398059
93GSK3A0.71115322
94STK380.69684644
95PRKD10.68736285
96PAK20.68609758
97PDK30.65344843
98PDK40.65344843
99PRKCE0.65334023
100PLK20.64994947
101FGFR30.64488493
102INSRR0.64214527
103CDC70.64150629
104MAP3K10.61572991
105MAP2K60.59944932
106RPS6KA40.57261095
107EPHA40.56647314
108ICK0.56235268
109MAP3K70.55740187
110CSNK1E0.55125551
111MAP3K100.54225796
112MUSK0.52605303
113RPS6KA20.51427768
114ADRBK10.50075073
115PASK0.49992403
116VRK20.49784238
117CSNK1G10.48537632
118PRKCI0.48046999
119ZAP700.47653201
120MOS0.46889631
121CDC42BPA0.44886707
122CAMK2D0.44694719
123CHUK0.43915996
124MAPK130.43361523
125ZAK0.42861294
126TYRO30.42231467
127DAPK20.42188936
128ROCK20.42184939
129LMTK20.42177732
130ERBB30.42138201
131DYRK30.42084578
132BRSK20.41868753
133KSR10.41439308
134STK100.40256914
135CAMK2A0.39929552
136LIMK10.39626137
137RPS6KA10.38844828
138TTK0.38800291
139DMPK0.38332215
140MAP2K20.36652690
141OXSR10.35369977
142PRKAA20.34146105
143IRAK10.33673649
144RPS6KL10.33482951
145RPS6KC10.33482951
146ACVR1B0.33370366
147CSNK1A10.33238884
148PLK10.32994448
149NME10.32854075
150PDK20.31834831
151CDK80.31601492
152UHMK10.30716925
153PRKD20.30533083
154MAPKAPK20.29993660
155TAOK10.29748213
156MAP2K10.29679384
157DYRK1A0.29326878
158ROCK10.29183633
159IGF1R0.26088658
160NLK0.23898784

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.82956274
2Caffeine metabolism_Homo sapiens_hsa002324.42949435
3Ribosome_Homo sapiens_hsa030102.96304640
4Oxidative phosphorylation_Homo sapiens_hsa001902.65548237
5ECM-receptor interaction_Homo sapiens_hsa045122.63679041
6Basal cell carcinoma_Homo sapiens_hsa052172.27260222
7Adherens junction_Homo sapiens_hsa045202.18567036
8Bladder cancer_Homo sapiens_hsa052192.09106299
9Cardiac muscle contraction_Homo sapiens_hsa042601.98425292
10Parkinsons disease_Homo sapiens_hsa050121.97392022
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95492266
12Hippo signaling pathway_Homo sapiens_hsa043901.92231781
13Folate biosynthesis_Homo sapiens_hsa007901.86332648
14Nicotine addiction_Homo sapiens_hsa050331.83853898
15Focal adhesion_Homo sapiens_hsa045101.82989650
16Tight junction_Homo sapiens_hsa045301.78117958
17Proteoglycans in cancer_Homo sapiens_hsa052051.73205854
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73196890
19Steroid biosynthesis_Homo sapiens_hsa001001.69333167
20Prolactin signaling pathway_Homo sapiens_hsa049171.67378059
21Amoebiasis_Homo sapiens_hsa051461.66922484
22Huntingtons disease_Homo sapiens_hsa050161.64939520
23Alzheimers disease_Homo sapiens_hsa050101.61354221
24Small cell lung cancer_Homo sapiens_hsa052221.58032956
25Protein digestion and absorption_Homo sapiens_hsa049741.53858442
26Hedgehog signaling pathway_Homo sapiens_hsa043401.52027668
27Galactose metabolism_Homo sapiens_hsa000521.50698278
28Fatty acid metabolism_Homo sapiens_hsa012121.48255286
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45386932
30Phototransduction_Homo sapiens_hsa047441.44211223
31Endometrial cancer_Homo sapiens_hsa052131.39719711
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38725513
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37354882
34Selenocompound metabolism_Homo sapiens_hsa004501.31558785
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31103505
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28583084
37Basal transcription factors_Homo sapiens_hsa030221.27663637
38Chronic myeloid leukemia_Homo sapiens_hsa052201.25661223
39Insulin secretion_Homo sapiens_hsa049111.24487557
40Glutamatergic synapse_Homo sapiens_hsa047241.22602383
41Acute myeloid leukemia_Homo sapiens_hsa052211.22551961
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21276714
43Thyroid cancer_Homo sapiens_hsa052161.18671411
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16633917
45RNA polymerase_Homo sapiens_hsa030201.16531570
46MicroRNAs in cancer_Homo sapiens_hsa052061.16008313
47Insulin resistance_Homo sapiens_hsa049311.15371517
48Taste transduction_Homo sapiens_hsa047421.15176574
49Pancreatic cancer_Homo sapiens_hsa052121.14688180
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14152130
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13490455
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.12214315
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10758521
54Butanoate metabolism_Homo sapiens_hsa006501.10151404
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10040337
56Renal cell carcinoma_Homo sapiens_hsa052111.10011377
57Circadian entrainment_Homo sapiens_hsa047131.08536594
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08192153
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07507914
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07379894
61TGF-beta signaling pathway_Homo sapiens_hsa043501.04333390
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03624893
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.03501356
64Linoleic acid metabolism_Homo sapiens_hsa005911.02716626
65AMPK signaling pathway_Homo sapiens_hsa041521.02713737
66Vibrio cholerae infection_Homo sapiens_hsa051101.01374339
67Wnt signaling pathway_Homo sapiens_hsa043100.99384656
68Nitrogen metabolism_Homo sapiens_hsa009100.99178078
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98909814
70Notch signaling pathway_Homo sapiens_hsa043300.98255289
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98248919
72mTOR signaling pathway_Homo sapiens_hsa041500.96969602
73Melanogenesis_Homo sapiens_hsa049160.96677127
74Pathways in cancer_Homo sapiens_hsa052000.94531427
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94314925
76Mineral absorption_Homo sapiens_hsa049780.94005063
77Melanoma_Homo sapiens_hsa052180.93683438
78Axon guidance_Homo sapiens_hsa043600.92881814
79GABAergic synapse_Homo sapiens_hsa047270.92527077
80Cocaine addiction_Homo sapiens_hsa050300.91241825
81Toxoplasmosis_Homo sapiens_hsa051450.89750896
82Ether lipid metabolism_Homo sapiens_hsa005650.89607511
83Prostate cancer_Homo sapiens_hsa052150.89450678
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89297255
85Dilated cardiomyopathy_Homo sapiens_hsa054140.87797280
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87623856
87Insulin signaling pathway_Homo sapiens_hsa049100.87323586
88VEGF signaling pathway_Homo sapiens_hsa043700.84646848
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.83941232
90Long-term depression_Homo sapiens_hsa047300.83208312
91Dopaminergic synapse_Homo sapiens_hsa047280.83104638
92ErbB signaling pathway_Homo sapiens_hsa040120.82707729
93Serotonergic synapse_Homo sapiens_hsa047260.81965590
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80863504
95PPAR signaling pathway_Homo sapiens_hsa033200.79466822
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.77444283
97Dorso-ventral axis formation_Homo sapiens_hsa043200.77390530
98Colorectal cancer_Homo sapiens_hsa052100.77389347
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75616862
100Sulfur relay system_Homo sapiens_hsa041220.74955975
101Non-small cell lung cancer_Homo sapiens_hsa052230.74566160
102RNA degradation_Homo sapiens_hsa030180.74239990
103Fanconi anemia pathway_Homo sapiens_hsa034600.73861217
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73701016
105Circadian rhythm_Homo sapiens_hsa047100.73009456
106Homologous recombination_Homo sapiens_hsa034400.72482429
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71936598
108Nucleotide excision repair_Homo sapiens_hsa034200.70862430
109cAMP signaling pathway_Homo sapiens_hsa040240.70602949
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69258541
111Retinol metabolism_Homo sapiens_hsa008300.68110566
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67595951
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67511769
114Endocytosis_Homo sapiens_hsa041440.67101166
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66797171
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66726520
117Morphine addiction_Homo sapiens_hsa050320.66664747
118Rap1 signaling pathway_Homo sapiens_hsa040150.65786612
119N-Glycan biosynthesis_Homo sapiens_hsa005100.65221389
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64742484
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64225323
122Lysosome_Homo sapiens_hsa041420.64132061
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63236217
124Chemical carcinogenesis_Homo sapiens_hsa052040.62650327
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.61695702
126Amphetamine addiction_Homo sapiens_hsa050310.61263093
127Sulfur metabolism_Homo sapiens_hsa009200.60647257
128Glucagon signaling pathway_Homo sapiens_hsa049220.59975745
129Estrogen signaling pathway_Homo sapiens_hsa049150.59722679
130Glioma_Homo sapiens_hsa052140.59279909
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57967543
132Vitamin B6 metabolism_Homo sapiens_hsa007500.57939483
133Pyruvate metabolism_Homo sapiens_hsa006200.54670581
134Hepatitis C_Homo sapiens_hsa051600.53755606
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53703213
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53274730
137Ovarian steroidogenesis_Homo sapiens_hsa049130.52679493
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50876272
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50039348
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49806921
141HTLV-I infection_Homo sapiens_hsa051660.49702751
142Propanoate metabolism_Homo sapiens_hsa006400.48535886
143Peroxisome_Homo sapiens_hsa041460.47696293
144Lysine degradation_Homo sapiens_hsa003100.47164891
145Gastric acid secretion_Homo sapiens_hsa049710.46456910
146Fatty acid degradation_Homo sapiens_hsa000710.46192378
147Metabolic pathways_Homo sapiens_hsa011000.45817346
148Collecting duct acid secretion_Homo sapiens_hsa049660.44124959
149HIF-1 signaling pathway_Homo sapiens_hsa040660.43681053
150Tryptophan metabolism_Homo sapiens_hsa003800.43632831
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42355023
152Olfactory transduction_Homo sapiens_hsa047400.41985237
153beta-Alanine metabolism_Homo sapiens_hsa004100.41376348
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41205754
155One carbon pool by folate_Homo sapiens_hsa006700.40496160
156Protein export_Homo sapiens_hsa030600.39823867
157Cholinergic synapse_Homo sapiens_hsa047250.39535048
158Phagosome_Homo sapiens_hsa041450.39360600
159FoxO signaling pathway_Homo sapiens_hsa040680.38758663
160Platelet activation_Homo sapiens_hsa046110.38243095
161Renin secretion_Homo sapiens_hsa049240.36555386
162Purine metabolism_Homo sapiens_hsa002300.35761051
163Fatty acid elongation_Homo sapiens_hsa000620.35362408
164Gap junction_Homo sapiens_hsa045400.34303079
165Viral myocarditis_Homo sapiens_hsa054160.34125341
166Arachidonic acid metabolism_Homo sapiens_hsa005900.32644997
167Ras signaling pathway_Homo sapiens_hsa040140.32512491
168Renin-angiotensin system_Homo sapiens_hsa046140.30774763
169Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29202405

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