IRX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)6.20576504
2* pattern specification involved in kidney development (GO:0061004)5.42190604
3chemical homeostasis within a tissue (GO:0048875)5.08582683
4motile cilium assembly (GO:0044458)5.00887350
5ear development (GO:0043583)5.00784844
6axonemal dynein complex assembly (GO:0070286)4.83442697
7hemidesmosome assembly (GO:0031581)4.55448830
8insulin-like growth factor receptor signaling pathway (GO:0048009)4.51695017
9desmosome organization (GO:0002934)4.38931889
10regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.32311738
11regulation of cardioblast differentiation (GO:0051890)4.31297252
12bundle of His cell to Purkinje myocyte communication (GO:0086069)4.23209507
13cilium or flagellum-dependent cell motility (GO:0001539)4.14207434
14paraxial mesoderm development (GO:0048339)4.12965200
15mammary gland epithelial cell differentiation (GO:0060644)4.09409423
16mitotic G1 DNA damage checkpoint (GO:0031571)4.02467115
17sarcomere organization (GO:0045214)3.92554080
18lung epithelium development (GO:0060428)3.92515320
19cardiac myofibril assembly (GO:0055003)3.90142911
20uterus development (GO:0060065)3.85621346
21plasma membrane repair (GO:0001778)3.77744694
22left/right pattern formation (GO:0060972)3.69982739
23G1 DNA damage checkpoint (GO:0044783)3.68927549
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68564054
25epithelial cell-cell adhesion (GO:0090136)3.62159616
26establishment or maintenance of monopolar cell polarity (GO:0061339)3.61089023
27establishment of monopolar cell polarity (GO:0061162)3.61089023
28cardiac right ventricle morphogenesis (GO:0003215)3.60794322
29semaphorin-plexin signaling pathway (GO:0071526)3.60740939
30regulation of water loss via skin (GO:0033561)3.58025847
31cilium movement (GO:0003341)3.56633824
32mitotic G1/S transition checkpoint (GO:0044819)3.54790511
33hippo signaling (GO:0035329)3.51714923
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.50631433
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49695906
36body morphogenesis (GO:0010171)3.47859901
37branching involved in salivary gland morphogenesis (GO:0060445)3.47501473
38phosphate ion homeostasis (GO:0055062)3.44405899
39trivalent inorganic anion homeostasis (GO:0072506)3.44405899
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.42740513
41embryonic body morphogenesis (GO:0010172)3.39813724
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.38505024
43negative regulation of cell fate specification (GO:0009996)3.36877158
44intestinal epithelial cell development (GO:0060576)3.36551166
45multicellular organismal water homeostasis (GO:0050891)3.33772275
46endocardial cushion morphogenesis (GO:0003203)3.32780381
47negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.31459948
48regulation of hippo signaling (GO:0035330)3.30586900
49establishment of skin barrier (GO:0061436)3.26869845
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26591814
51heart trabecula formation (GO:0060347)3.26536275
52response to food (GO:0032094)3.24816455
53polarized epithelial cell differentiation (GO:0030859)3.22522260
54negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.21957265
55myofibril assembly (GO:0030239)3.19347352
56regulation of heart morphogenesis (GO:2000826)3.16910762
57regulation of cell proliferation involved in kidney development (GO:1901722)3.15901567
58negative regulation of potassium ion transmembrane transport (GO:1901380)3.15260940
59renal filtration (GO:0097205)3.14939370
60norepinephrine metabolic process (GO:0042415)3.14425289
61mesenchyme morphogenesis (GO:0072132)3.13009600
62cell-substrate junction assembly (GO:0007044)3.12497158
63ventricular cardiac muscle cell action potential (GO:0086005)3.11680517
64basement membrane organization (GO:0071711)3.10569749
65atrioventricular valve morphogenesis (GO:0003181)3.10429241
66outer ear morphogenesis (GO:0042473)3.10401646
67embryonic cranial skeleton morphogenesis (GO:0048701)3.10054374
68cardiac muscle cell proliferation (GO:0060038)3.09106143
69epithelial cilium movement (GO:0003351)3.07011347
70apical protein localization (GO:0045176)3.06358681
71ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.04752765
72endocardial cushion development (GO:0003197)3.04367334
73outflow tract septum morphogenesis (GO:0003148)3.02058241
74maternal placenta development (GO:0001893)3.01334633
75lung secretory cell differentiation (GO:0061140)2.99563505
76ectoderm development (GO:0007398)2.99142850
77glomerular filtration (GO:0003094)2.97935381
78face development (GO:0060324)2.96720806
79mammary gland alveolus development (GO:0060749)2.95800976
80actomyosin structure organization (GO:0031032)2.95311476
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94380039
82lung-associated mesenchyme development (GO:0060484)2.94203435
83heart valve formation (GO:0003188)2.92982698
84cardiac muscle cell development (GO:0055013)2.92150978
85cell-cell junction maintenance (GO:0045217)2.92072408
86cardiac cell development (GO:0055006)2.90711811
87lymph vessel development (GO:0001945)2.88727836
88regulation of fatty acid beta-oxidation (GO:0031998)2.87853287
89trabecula formation (GO:0060343)2.86956944
90regulation of somitogenesis (GO:0014807)2.86637776
91cardiac muscle tissue morphogenesis (GO:0055008)2.85972096
92cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85943138
93* segment specification (GO:0007379)2.85609208
94embryonic camera-type eye development (GO:0031076)2.83730091
95embryonic foregut morphogenesis (GO:0048617)2.81942378
96negative regulation of cell size (GO:0045792)2.81706999
97regulation of establishment of planar polarity (GO:0090175)2.81252096
98notochord development (GO:0030903)2.78608356
99muscle filament sliding (GO:0030049)2.78179320
100actin-myosin filament sliding (GO:0033275)2.78179320
101proximal/distal pattern formation (GO:0009954)2.78032829
102regulation of cell fate specification (GO:0042659)2.77358912
103branching involved in mammary gland duct morphogenesis (GO:0060444)2.77337458
104primary alcohol catabolic process (GO:0034310)2.77318205
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76982781
106regulation of interleukin-13 production (GO:0032656)2.76846510
107establishment of tissue polarity (GO:0007164)2.74909313
108establishment of planar polarity (GO:0001736)2.74909313
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.74159875
110negative regulation of fatty acid transport (GO:2000192)2.73264895
111prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.72524230
112asymmetric protein localization (GO:0008105)2.71997316
113endothelial cell chemotaxis (GO:0035767)2.71856778
114type B pancreatic cell proliferation (GO:0044342)2.71181222
115positive regulation of epithelial to mesenchymal transition (GO:0010718)2.70595878
116glomerular basement membrane development (GO:0032836)2.69663909
117regulation of p38MAPK cascade (GO:1900744)2.69359196
118cell migration involved in sprouting angiogenesis (GO:0002042)2.68093220
119non-canonical Wnt signaling pathway (GO:0035567)2.67633377
120vascular endothelial growth factor signaling pathway (GO:0038084)2.66631732
121skin morphogenesis (GO:0043589)2.66555567
122muscle tissue morphogenesis (GO:0060415)2.66359579
123amyloid precursor protein catabolic process (GO:0042987)2.65646579
124epithelial cell maturation (GO:0002070)2.65565108
125regulation of tight junction assembly (GO:2000810)2.65092050
126cytoplasmic mRNA processing body assembly (GO:0033962)2.64550495
127collagen fibril organization (GO:0030199)2.64471541
128glucocorticoid biosynthetic process (GO:0006704)2.63095340
129bone trabecula formation (GO:0060346)2.62889573
130cochlea morphogenesis (GO:0090103)2.62534558
131phosphate ion transport (GO:0006817)2.62192353
132endocrine hormone secretion (GO:0060986)2.62190994
133negative regulation of catenin import into nucleus (GO:0035414)2.62027927
134collecting duct development (GO:0072044)2.61645230
135lens fiber cell development (GO:0070307)2.61511305
136mesenchyme development (GO:0060485)2.59915011
137negative regulation of chondrocyte differentiation (GO:0032331)2.59622015
138wound healing, spreading of epidermal cells (GO:0035313)2.59449451
139cell migration involved in heart development (GO:0060973)2.59232769
140axon extension involved in axon guidance (GO:0048846)2.58935282
141neuron projection extension involved in neuron projection guidance (GO:1902284)2.58935282
142endodermal cell differentiation (GO:0035987)2.58711559
143establishment of apical/basal cell polarity (GO:0035089)2.57543947
144cardiac muscle contraction (GO:0060048)2.57392373
145cell adhesion mediated by integrin (GO:0033627)2.57124144
146water homeostasis (GO:0030104)2.56877989
147heart valve morphogenesis (GO:0003179)2.56466275
148chondrocyte proliferation (GO:0035988)2.56426291
149mesodermal cell differentiation (GO:0048333)2.55971658
150regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.53262408
151regulation of transforming growth factor beta2 production (GO:0032909)2.52722613
152cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52443673
153cell junction maintenance (GO:0034331)2.52308938
154actin-mediated cell contraction (GO:0070252)2.51764870
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.50432632
156phosphate ion transmembrane transport (GO:0035435)2.50145693
157Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49706874
158adherens junction assembly (GO:0034333)2.49062052
159positive regulation of stem cell differentiation (GO:2000738)2.48876610
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48558124
161positive regulation of mesenchymal cell proliferation (GO:0002053)2.47591820
162negative regulation of embryonic development (GO:0045992)2.46606480
163mesenchymal cell proliferation (GO:0010463)2.46377939
164lateral sprouting from an epithelium (GO:0060601)2.45644013
165cellular response to lithium ion (GO:0071285)2.44666961
166positive regulation of keratinocyte differentiation (GO:0045618)2.44315956
167regulation of chromatin binding (GO:0035561)2.43627420
168mammary gland epithelial cell proliferation (GO:0033598)2.43551639
169regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42782389
170pharyngeal system development (GO:0060037)2.42499337
171mesonephros development (GO:0001823)2.40105102
172positive regulation of vascular permeability (GO:0043117)2.38958983
173multicellular organismal movement (GO:0050879)2.36948948
174musculoskeletal movement (GO:0050881)2.36948948
175glandular epithelial cell differentiation (GO:0002067)2.36393711
176camera-type eye morphogenesis (GO:0048593)2.34355645
177negative regulation of kidney development (GO:0090185)2.33992128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.64471196
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.53706672
3* TRIM28_21343339_ChIP-Seq_HEK293_Human3.91003665
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.44950215
5CLOCK_20551151_ChIP-Seq_293T_Human2.99355973
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.89364015
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.86607357
8ZNF263_19887448_ChIP-Seq_K562_Human2.68548656
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.65998775
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.57276322
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39423598
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.28413352
13* ERG_21242973_ChIP-ChIP_JURKAT_Human2.17928454
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.17839661
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12207655
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09679594
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.09041200
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.08637617
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06600515
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03780497
21TBX20_22328084_ChIP-Seq_HEART_Mouse2.03410357
22TBX20_22080862_ChIP-Seq_HEART_Mouse2.03410357
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02916248
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01560428
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95258818
26* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90181689
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87591921
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.86790496
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.82316592
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77503518
31* VDR_21846776_ChIP-Seq_THP-1_Human1.75299114
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74550029
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73817894
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73298472
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71617654
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.69167673
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59843706
38SMC4_20622854_ChIP-Seq_HELA_Human1.59089954
39P68_20966046_ChIP-Seq_HELA_Human1.57193370
40* TP53_20018659_ChIP-ChIP_R1E_Mouse1.51702018
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.51604694
42CTCF_27219007_Chip-Seq_Bcells_Human1.50527941
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49598517
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.48397797
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46387645
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45871881
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45017403
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.44837003
49KDM2B_26808549_Chip-Seq_K562_Human1.44695074
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44129687
51* RUNX1_27514584_Chip-Seq_MCF-7_Human1.43141549
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41964295
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.40904076
54CJUN_26792858_Chip-Seq_BT549_Human1.40723005
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.39098626
56ATF3_27146783_Chip-Seq_COLON_Human1.38093456
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.37376679
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36156434
59* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36085209
60* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36085209
61LXR_22292898_ChIP-Seq_THP-1_Human1.35664415
62AHR_22903824_ChIP-Seq_MCF-7_Human1.34888398
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34686606
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34532961
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34493665
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33608801
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33608801
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33366844
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32208616
70* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31026458
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27827482
72SOX2_20726797_ChIP-Seq_SW620_Human1.26752019
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26730697
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26596921
75* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26198335
76* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26136837
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25577988
78* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25493167
79* EED_16625203_ChIP-ChIP_MESCs_Mouse1.24358320
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22788674
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22174272
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21717251
83* KDM2B_26808549_Chip-Seq_DND41_Human1.20972965
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20661444
85TP63_22573176_ChIP-Seq_HFKS_Human1.20389089
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.18695559
87* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18187097
88TCF7_22412390_ChIP-Seq_EML_Mouse1.17505528
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16066689
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15246240
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.12357167
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11428390
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11354062
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11132180
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09605642
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09605642
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09605642
98* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08495960
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07509126
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07377791
101KLF5_25053715_ChIP-Seq_YYC3_Human1.07220584
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06778015
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.06153207
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05838659
105* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05431620
106TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05076622
107CREB1_26743006_Chip-Seq_LNCaP_Human1.05022065
108* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04663140
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04596302
110SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03949332
111* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03551092
112* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02944955
113* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01819172
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.01437537
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01248706
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00364176
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00253791
118CHD1_26751641_Chip-Seq_LNCaP_Human0.98082484
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97400127
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.97163523
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96637759
122TP53_22127205_ChIP-Seq_IMR90_Human0.96184477
123* EZH2_27304074_Chip-Seq_ESCs_Mouse0.96173312
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95822843
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95610104
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.95586158
127* RNF2_27304074_Chip-Seq_ESCs_Mouse0.94956366
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94573988
129* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94277687
130* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93968824
131* EZH2_27294783_Chip-Seq_ESCs_Mouse0.93801954
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.93560782
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93329847
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91175705
135* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91041017
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90041056
137GATA6_25053715_ChIP-Seq_YYC3_Human0.89029900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.74135106
2MP0003705_abnormal_hypodermis_morpholog3.17731367
3MP0004272_abnormal_basement_membrane2.94254205
4MP0004084_abnormal_cardiac_muscle2.91648757
5MP0010030_abnormal_orbit_morphology2.74885397
6MP0004381_abnormal_hair_follicle2.72887294
7MP0001958_emphysema2.69360475
8MP0005275_abnormal_skin_tensile2.58530004
9MP0008438_abnormal_cutaneous_collagen2.48014294
10MP0005623_abnormal_meninges_morphology2.41099877
11MP0004782_abnormal_surfactant_physiolog2.40234906
12MP0000751_myopathy2.35923589
13MP0000566_synostosis2.30484858
14MP0000537_abnormal_urethra_morphology2.22493937
15MP0002837_dystrophic_cardiac_calcinosis2.09627167
16MP0003941_abnormal_skin_development2.06540696
17MP0003566_abnormal_cell_adhesion2.06456702
18MP0010234_abnormal_vibrissa_follicle2.05551702
19MP0002796_impaired_skin_barrier2.04038166
20MP0010368_abnormal_lymphatic_system1.89397850
21MP0009379_abnormal_foot_pigmentation1.78919668
22MP0002234_abnormal_pharynx_morphology1.74649149
23MP0005330_cardiomyopathy1.74364573
24MP0006138_congestive_heart_failure1.66154316
25MP0002282_abnormal_trachea_morphology1.66124550
26MP0006054_spinal_hemorrhage1.66008207
27MP0005409_darkened_coat_color1.64717343
28MP0004036_abnormal_muscle_relaxation1.64258498
29MP0004858_abnormal_nervous_system1.64006445
30MP0004215_abnormal_myocardial_fiber1.62593647
31MP0000750_abnormal_muscle_regeneration1.60812351
32MP0009053_abnormal_anal_canal1.60115896
33MP0000579_abnormal_nail_morphology1.59452131
34MP0004264_abnormal_extraembryonic_tissu1.55926726
35MP0001881_abnormal_mammary_gland1.55877745
36MP0005503_abnormal_tendon_morphology1.55347985
37MP0005083_abnormal_biliary_tract1.55218448
38MP0004087_abnormal_muscle_fiber1.54945872
39MP0000762_abnormal_tongue_morphology1.54903542
40MP0010630_abnormal_cardiac_muscle1.53925342
41MP0003279_aneurysm1.53364263
42MP0000627_abnormal_mammary_gland1.51846773
43MP0001849_ear_inflammation1.49476824
44MP0002972_abnormal_cardiac_muscle1.47495472
45MP0003385_abnormal_body_wall1.43314473
46MP0009384_cardiac_valve_regurgitation1.42608452
47MP0005377_hearing/vestibular/ear_phenot1.41643409
48MP0003878_abnormal_ear_physiology1.41643409
49MP0002098_abnormal_vibrissa_morphology1.41101077
50MP0005385_cardiovascular_system_phenoty1.38646571
51MP0001544_abnormal_cardiovascular_syste1.38646571
52MP0000733_abnormal_muscle_development1.38458934
53MP0005248_abnormal_Harderian_gland1.36712778
54MP0003115_abnormal_respiratory_system1.35717319
55MP0000534_abnormal_ureter_morphology1.32711295
56MP0003567_abnormal_fetal_cardiomyocyte1.32352066
57MP0008775_abnormal_heart_ventricle1.32167638
58MP0003828_pulmonary_edema1.32073206
59MP0002160_abnormal_reproductive_system1.31743992
60MP0003136_yellow_coat_color1.31476741
61MP0000427_abnormal_hair_cycle1.28709050
62MP0002060_abnormal_skin_morphology1.28006122
63MP0005501_abnormal_skin_physiology1.27590546
64MP0000678_abnormal_parathyroid_gland1.26222909
65MP0003646_muscle_fatigue1.25881366
66MP0003942_abnormal_urinary_system1.24264840
67MP0001879_abnormal_lymphatic_vessel1.23365383
68MP0003137_abnormal_impulse_conducting1.20956301
69MP0000749_muscle_degeneration1.19979332
70MP0004185_abnormal_adipocyte_glucose1.18278948
71MP0009250_abnormal_appendicular_skeleto1.17394462
72MP0002277_abnormal_respiratory_mucosa1.16871898
73MP0002295_abnormal_pulmonary_circulatio1.14944653
74MP0005508_abnormal_skeleton_morphology1.14556399
75MP0004133_heterotaxia1.14227066
76MP0000428_abnormal_craniofacial_morphol1.13283459
77MP0010771_integument_phenotype1.10845274
78MP0005666_abnormal_adipose_tissue1.09652519
79MP0005620_abnormal_muscle_contractility1.09264784
80MP0002896_abnormal_bone_mineralization1.08944040
81MP0001984_abnormal_olfaction1.08762829
82MP0002249_abnormal_larynx_morphology1.08009161
83MP0005076_abnormal_cell_differentiation1.07859563
84MP0005023_abnormal_wound_healing1.07610453
85MP0010678_abnormal_skin_adnexa1.07344672
86MP0003936_abnormal_reproductive_system1.07150785
87MP0002932_abnormal_joint_morphology1.07011092
88MP0000767_abnormal_smooth_muscle1.05561061
89MP0003938_abnormal_ear_development1.05455097
90MP0001346_abnormal_lacrimal_gland1.03938421
91MP0000383_abnormal_hair_follicle1.02899238
92MP0008875_abnormal_xenobiotic_pharmacok1.01697195
93MP0004233_abnormal_muscle_weight1.00987958
94MP0004484_altered_response_of1.00409162
95MP0001216_abnormal_epidermal_layer1.00085997
96MP0008995_early_reproductive_senescence0.99720020
97MP0002108_abnormal_muscle_morphology0.98668907
98MP0000049_abnormal_middle_ear0.98523195
99MP0000467_abnormal_esophagus_morphology0.96765066
100MP0002116_abnormal_craniofacial_bone0.96428017
101MP0005367_renal/urinary_system_phenotyp0.96201160
102MP0000516_abnormal_urinary_system0.96201160
103MP0010352_gastrointestinal_tract_polyps0.96171381
104MP0002106_abnormal_muscle_physiology0.95770777
105MP0003453_abnormal_keratinocyte_physiol0.94889672
106MP0005375_adipose_tissue_phenotype0.94805472
107MP0001542_abnormal_bone_strength0.94196188
108MP0000759_abnormal_skeletal_muscle0.93591218
109MP0002133_abnormal_respiratory_system0.93199228
110MP0005388_respiratory_system_phenotype0.93199228
111MP0003935_abnormal_craniofacial_develop0.92978865
112MP0001919_abnormal_reproductive_system0.92921822
113MP0003950_abnormal_plasma_membrane0.92753532
114MP0002925_abnormal_cardiovascular_devel0.92594345
115MP0000377_abnormal_hair_follicle0.92428672
116MP0002233_abnormal_nose_morphology0.91331918
117MP0000163_abnormal_cartilage_morphology0.90762895
118MP0003119_abnormal_digestive_system0.90736377
119MP0002653_abnormal_ependyma_morphology0.90096290
120MP0005369_muscle_phenotype0.89661861
121MP0003091_abnormal_cell_migration0.85360285
122MP0000266_abnormal_heart_morphology0.85324204
123MP0001873_stomach_inflammation0.85189951
124MP0003787_abnormal_imprinting0.83964284
125MP0002128_abnormal_blood_circulation0.83142167
126MP0001340_abnormal_eyelid_morphology0.82905984
127MP0003755_abnormal_palate_morphology0.82409316
128MP0005187_abnormal_penis_morphology0.81966322
129MP0003937_abnormal_limbs/digits/tail_de0.81701208
130MP0005058_abnormal_lysosome_morphology0.80232387
131MP0005646_abnormal_pituitary_gland0.80021963
132MP0009672_abnormal_birth_weight0.78798784
133MP0001727_abnormal_embryo_implantation0.77332303
134MP0003123_paternal_imprinting0.77236935
135MP0002184_abnormal_innervation0.75010924
136MP0002089_abnormal_postnatal_growth/wei0.74374610
137MP0000003_abnormal_adipose_tissue0.73964567
138MP0002084_abnormal_developmental_patter0.73165273
139MP0005408_hypopigmentation0.71644568
140MP0000470_abnormal_stomach_morphology0.70862065
141MP0002697_abnormal_eye_size0.69038384
142MP0002009_preneoplasia0.67591406
143MP0002085_abnormal_embryonic_tissue0.67036382
144MP0000462_abnormal_digestive_system0.67004897
145MP0005075_abnormal_melanosome_morpholog0.66874757
146MP0001348_abnormal_lacrimal_gland0.65154696

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.76137930
2Sparse lateral eyebrow (HP:0005338)4.74036435
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26207303
4Ventricular tachycardia (HP:0004756)4.06726569
5Sudden death (HP:0001699)4.06016440
6Protrusio acetabuli (HP:0003179)3.74503808
7Broad metatarsal (HP:0001783)3.66786790
8Shallow orbits (HP:0000586)3.66174311
9Premature rupture of membranes (HP:0001788)3.61741400
10Septate vagina (HP:0001153)3.57634440
11Atrophic scars (HP:0001075)3.57428077
12Abnormal respiratory epithelium morphology (HP:0012253)3.55888126
13Abnormal respiratory motile cilium morphology (HP:0005938)3.55888126
14Muscle fiber splitting (HP:0003555)3.46694934
15Abnormal respiratory motile cilium physiology (HP:0012261)3.44141157
16Interstitial pulmonary disease (HP:0006530)3.34391354
17Absent/shortened dynein arms (HP:0200106)3.22600313
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.22600313
19Hypoparathyroidism (HP:0000829)3.21412507
20Absent frontal sinuses (HP:0002688)3.17141187
21Abnormal ciliary motility (HP:0012262)3.12004586
22Lip pit (HP:0100267)3.11265942
23Increased connective tissue (HP:0009025)3.09879445
24Rhinitis (HP:0012384)3.04689892
25Concave nail (HP:0001598)3.04290387
26Aplasia of the musculature (HP:0100854)2.98393288
27Severe Myopia (HP:0011003)2.93151925
28Hyporeflexia of lower limbs (HP:0002600)2.81092669
29Onycholysis (HP:0001806)2.80982507
30Chronic bronchitis (HP:0004469)2.79010646
31Abnormality of the calf musculature (HP:0001430)2.76689481
32Milia (HP:0001056)2.75150524
33Atelectasis (HP:0100750)2.74094455
34Asymmetry of the thorax (HP:0001555)2.73130686
35Infantile muscular hypotonia (HP:0008947)2.72673848
36Gout (HP:0001997)2.71397757
37Hypercortisolism (HP:0001578)2.69730308
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69337282
39Hypoplastic ischia (HP:0003175)2.63474761
40Fragile nails (HP:0001808)2.62914431
41Atrial fibrillation (HP:0005110)2.61191761
42Down-sloping shoulders (HP:0200021)2.59402939
43Epiphyseal dysplasia (HP:0002656)2.54024868
44Cerebral aneurysm (HP:0004944)2.51806374
45Hyperparathyroidism (HP:0000843)2.49117413
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.48331146
47Renal dysplasia (HP:0000110)2.47313986
48Lymphangioma (HP:0100764)2.46386443
49Ankle contracture (HP:0006466)2.45239397
50Long toe (HP:0010511)2.44881763
51Primary atrial arrhythmia (HP:0001692)2.43477805
52Lipoatrophy (HP:0100578)2.42445127
53Obstructive sleep apnea (HP:0002870)2.41385094
54Exercise-induced muscle cramps (HP:0003710)2.39147286
55Supraventricular arrhythmia (HP:0005115)2.36549552
56Bronchomalacia (HP:0002780)2.35012942
57Partial duplication of thumb phalanx (HP:0009944)2.33399320
58Mitral regurgitation (HP:0001653)2.32428100
59Broad distal phalanx of finger (HP:0009836)2.31309333
60Supraventricular tachycardia (HP:0004755)2.31040687
61Neonatal short-limb short stature (HP:0008921)2.28167456
62Hyperactive renin-angiotensin system (HP:0000841)2.27411340
63Abnormality of the ischium (HP:0003174)2.27018916
64Partial duplication of the phalanx of hand (HP:0009999)2.26668948
65Difficulty climbing stairs (HP:0003551)2.26068249
66J-shaped sella turcica (HP:0002680)2.23739265
67Calf muscle hypertrophy (HP:0008981)2.23065241
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.22442100
69Abnormality of the distal phalanges of the toes (HP:0010182)2.22275823
70Fragile skin (HP:0001030)2.21348424
71Hypoplasia of the iris (HP:0007676)2.20980353
72Shawl scrotum (HP:0000049)2.19937864
73Mildly elevated creatine phosphokinase (HP:0008180)2.18353725
74Abnormality of the frontal sinuses (HP:0002687)2.13706579
75Spinal rigidity (HP:0003306)2.12206271
76Abnormality of the dental root (HP:0006486)2.12187166
77Taurodontia (HP:0000679)2.12187166
78Abnormality of permanent molar morphology (HP:0011071)2.12187166
79Hyperacusis (HP:0010780)2.11627892
80Abnormality of the left ventricular outflow tract (HP:0011103)2.11444187
81Subaortic stenosis (HP:0001682)2.11444187
82Type 1 muscle fiber predominance (HP:0003803)2.10379968
83Woolly hair (HP:0002224)2.10280855
84Hip contracture (HP:0003273)2.09828051
85Preauricular skin tag (HP:0000384)2.09619428
86Abnormality of the 2nd finger (HP:0004100)2.09192046
87Renal salt wasting (HP:0000127)2.08432619
88Syncope (HP:0001279)2.07403126
89Abnormality of molar morphology (HP:0011070)2.06487514
90Abnormality of molar (HP:0011077)2.06487514
91Difficulty running (HP:0009046)2.04695288
92Scapular winging (HP:0003691)2.04488145
93Flat acetabular roof (HP:0003180)2.04056921
94Ventricular arrhythmia (HP:0004308)2.00775274
95Nasal polyposis (HP:0100582)1.99950609
96Limb-girdle muscle atrophy (HP:0003797)1.98702324
97Increased variability in muscle fiber diameter (HP:0003557)1.98262244
98Short nail (HP:0001799)1.97753571
99Knee flexion contracture (HP:0006380)1.97674074
100Aortic dissection (HP:0002647)1.97343469
101Visceral angiomatosis (HP:0100761)1.97283703
102Coronal craniosynostosis (HP:0004440)1.96470051
103Popliteal pterygium (HP:0009756)1.95933457
104Abnormality of the aortic arch (HP:0012303)1.95843433
105Dilated cardiomyopathy (HP:0001644)1.95702193
106Resting tremor (HP:0002322)1.94938673
107Respiratory distress (HP:0002098)1.93004339
108EMG: myopathic abnormalities (HP:0003458)1.92471820
109Distal lower limb muscle weakness (HP:0009053)1.91854018
110Exercise-induced myalgia (HP:0003738)1.91630286
111Advanced eruption of teeth (HP:0006288)1.89228987
112Mitral valve prolapse (HP:0001634)1.89209462
113Hip dysplasia (HP:0001385)1.88577837
114Exostoses (HP:0100777)1.88432740
115Abnormal vertebral ossification (HP:0100569)1.86151408
116Thin bony cortex (HP:0002753)1.85947132
117Muscle hypertrophy of the lower extremities (HP:0008968)1.85860774
118Ventricular fibrillation (HP:0001663)1.84870911
119Overgrowth (HP:0001548)1.84858475
120Bladder diverticulum (HP:0000015)1.84032449
121Wide anterior fontanel (HP:0000260)1.83898980
122Cervical subluxation (HP:0003308)1.83845659
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83439395
124Hemangiomatosis (HP:0007461)1.83327458
125Ulnar bowing (HP:0003031)1.83275053
126Abnormality of the dental pulp (HP:0006479)1.83125863
127Bell-shaped thorax (HP:0001591)1.82636462
128Abnormality of chloride homeostasis (HP:0011422)1.82478038
129Spinal cord compression (HP:0002176)1.82195277
130Double outlet right ventricle (HP:0001719)1.82144391
131Congenital malformation of the right heart (HP:0011723)1.82144391
132Turricephaly (HP:0000262)1.82087826
133Aneurysm (HP:0002617)1.81565843
134Buphthalmos (HP:0000557)1.80784518
135Infertility (HP:0000789)1.80259304
136Pili torti (HP:0003777)1.78851107
137Rectal prolapse (HP:0002035)1.77635110
138Blue sclerae (HP:0000592)1.76689664
139Rib fusion (HP:0000902)1.76276081
140Short femoral neck (HP:0100864)1.75887127
141Skin tags (HP:0010609)1.75880092
142Oligodontia (HP:0000677)1.75785352
143Germ cell neoplasia (HP:0100728)1.74574339
144Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74231761
145Congenital glaucoma (HP:0001087)1.72736249
146Bronchiectasis (HP:0002110)1.72734246
147Nasolacrimal duct obstruction (HP:0000579)1.72676765
148Abnormality of the thoracic spine (HP:0100711)1.71980429
149Increased purine levels (HP:0004368)1.71735924
150Hyperuricemia (HP:0002149)1.71735924
151Abnormality of skeletal muscle fiber size (HP:0012084)1.69671498
152Vertebral arch anomaly (HP:0008438)1.68647528
153Morphological abnormality of the middle ear (HP:0008609)1.68618028
154Abnormality of nail color (HP:0100643)1.68352484
155Elbow flexion contracture (HP:0002987)1.67669920
156Tachypnea (HP:0002789)1.66568796
157Abnormality of the umbilical cord (HP:0010881)1.64653029
158Myoglobinuria (HP:0002913)1.64634582
159Hypochromic anemia (HP:0001931)1.64470641
160Palpitations (HP:0001962)1.64209652
161Prolonged QT interval (HP:0001657)1.63647232
162Bundle branch block (HP:0011710)1.63274669
163Tubulointerstitial fibrosis (HP:0005576)1.62856514
164Alopecia of scalp (HP:0002293)1.62205137
165Asymmetric septal hypertrophy (HP:0001670)1.62188892
166Renal duplication (HP:0000075)1.62013723
167Abnormality of the nasal mucosa (HP:0000433)1.62002179
168Pterygium (HP:0001059)1.61912948
169Hyperthyroidism (HP:0000836)1.61781749
170Abnormality of the pubic bones (HP:0003172)1.60168490
171Vesicoureteral reflux (HP:0000076)1.59672756
172Hypotrichosis (HP:0001006)1.59616881
173Macroorchidism (HP:0000053)1.58926580
174Natal tooth (HP:0000695)1.56473539
175Testicular atrophy (HP:0000029)1.55643158
176Enlarged penis (HP:0000040)1.52139509
177Flattened epiphyses (HP:0003071)1.50002624
178Flat capital femoral epiphysis (HP:0003370)1.49700802
179Abnormality of the lacrimal duct (HP:0011481)1.48123254
180Microretrognathia (HP:0000308)1.47299248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.23636581
2PIM24.04114237
3DDR23.43409646
4EPHB23.33864398
5TTN3.10551481
6PKN23.04585949
7LATS12.93384245
8TIE12.73122918
9WNK42.68815560
10SMG12.39374831
11SIK12.29715371
12FER2.23944866
13MUSK2.18401933
14RIPK12.09094856
15PDGFRA2.04538877
16PTK62.01885299
17LATS21.96607976
18LRRK21.94191349
19FGFR21.89884310
20LMTK21.85821567
21RPS6KA21.76086761
22STK38L1.66154589
23PAK41.63886054
24CDK81.63678407
25EPHB11.62404719
26STK241.58745242
27DMPK1.57053798
28ILK1.54799756
29ERN11.52595173
30EPHA31.47619220
31MYLK1.45317784
32EPHA21.44777863
33TGFBR21.38279189
34FGFR41.36079437
35BMPR1B1.30815978
36TGFBR11.25632258
37CDK71.23064848
38MAP3K101.22096077
39TRPM71.19436305
40RPS6KA61.18738165
41STK391.16458378
42FGFR11.15750677
43PDK41.13887335
44PDK31.13887335
45PAK31.13231242
46PHKG21.11228211
47PHKG11.11228211
48PTK21.10999241
49NEK11.10993660
50BMX1.10271678
51PRKD11.07598850
52MAP3K31.07345054
53MET1.07258832
54MST1R1.02582543
55PDGFRB0.98341882
56EEF2K0.96467641
57ICK0.92364258
58PAK20.90205391
59MAP3K90.89847307
60DYRK1B0.89736009
61BCKDK0.89412067
62CAMK2G0.86578359
63CDK60.86225647
64CHUK0.85715057
65MAP3K60.84780826
66ROCK10.83773696
67WNK10.83509388
68WNK30.82498627
69ERBB20.82396105
70NME20.82314513
71HIPK20.81318588
72PIK3CA0.79761030
73STK30.79547504
74NME10.78578164
75MTOR0.74473454
76CAMK2D0.73818481
77MARK20.71390962
78CAMK1D0.70302296
79ROCK20.70053411
80NEK60.69210931
81PRKD20.68331576
82PDPK10.66871194
83MAP2K20.66770732
84NEK90.65034438
85LIMK10.64719366
86PDK20.64102255
87BRD40.63684244
88CAMK1G0.63304437
89DAPK30.63254858
90STK100.62788596
91CAMK2B0.61910650
92STK380.61709664
93MAPK40.61487419
94FGFR30.61087140
95MAP3K70.59894093
96PTK2B0.59548030
97CDC42BPA0.59530381
98MAPKAPK20.59339075
99KDR0.58011412
100AKT20.57508206
101CDK90.57096766
102MAPKAPK30.56848939
103TYRO30.55814518
104RET0.53118454
105RPS6KB10.50721840
106GSK3A0.50506063
107OBSCN0.48799738
108RPS6KB20.48126269
109IRAK30.47248467
110MST40.45928934
111AURKA0.45615492
112MAP3K110.44636271
113CSNK1E0.44016528
114CAMKK10.43629845
115TESK10.43556044
116OXSR10.42921152
117TBK10.42370450
118MAP2K10.41140959
119PRKAA10.39590433
120ERBB30.39531578
121ABL20.39500521
122EIF2AK10.39449305
123RPS6KA40.37684148
124RPS6KA10.36619088
125RPS6KL10.34885094
126RPS6KC10.34885094
127KSR10.34617981
128MAPK150.33604199
129AKT10.33221422
130MAPK80.33216775
131BCR0.32989875
132GRK60.32815828
133TAOK10.32478204
134MAPK120.31224932
135PRKCH0.30323984
136MAPK140.29272404
137CHEK20.27809107
138PRKCI0.27527455
139PRKG20.25665704
140PRKD30.24541985

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.19553896
2Sulfur relay system_Homo sapiens_hsa041223.10610412
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05124955
4Basal cell carcinoma_Homo sapiens_hsa052172.70233858
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.67015357
6Dilated cardiomyopathy_Homo sapiens_hsa054142.61696555
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.59942123
8Hippo signaling pathway_Homo sapiens_hsa043902.46640811
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41282763
10Adherens junction_Homo sapiens_hsa045202.37156519
11Focal adhesion_Homo sapiens_hsa045102.19050158
12Tight junction_Homo sapiens_hsa045301.95351989
13Proteoglycans in cancer_Homo sapiens_hsa052051.93322636
14Fatty acid degradation_Homo sapiens_hsa000711.91868485
15Hedgehog signaling pathway_Homo sapiens_hsa043401.86919533
16Propanoate metabolism_Homo sapiens_hsa006401.78594905
17Bladder cancer_Homo sapiens_hsa052191.77749147
18Protein digestion and absorption_Homo sapiens_hsa049741.77183294
19Cardiac muscle contraction_Homo sapiens_hsa042601.54329760
20Notch signaling pathway_Homo sapiens_hsa043301.53629980
21Fatty acid metabolism_Homo sapiens_hsa012121.52904291
22Small cell lung cancer_Homo sapiens_hsa052221.51683160
23Viral myocarditis_Homo sapiens_hsa054161.51095001
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48266603
25TGF-beta signaling pathway_Homo sapiens_hsa043501.43558474
26Histidine metabolism_Homo sapiens_hsa003401.40746534
27Tyrosine metabolism_Homo sapiens_hsa003501.40288721
28Ribosome_Homo sapiens_hsa030101.39285724
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35136820
30Amoebiasis_Homo sapiens_hsa051461.32960887
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.32252807
32Lysine degradation_Homo sapiens_hsa003101.27890415
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27095867
34Choline metabolism in cancer_Homo sapiens_hsa052311.25451854
35MicroRNAs in cancer_Homo sapiens_hsa052061.23562602
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18433714
37Circadian rhythm_Homo sapiens_hsa047101.18155510
38Carbon metabolism_Homo sapiens_hsa012001.18127847
39Renal cell carcinoma_Homo sapiens_hsa052111.17439353
40Melanogenesis_Homo sapiens_hsa049161.17415206
41Fatty acid biosynthesis_Homo sapiens_hsa000611.14409884
42Wnt signaling pathway_Homo sapiens_hsa043101.14227532
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10473027
44Endometrial cancer_Homo sapiens_hsa052131.09793843
45Pyruvate metabolism_Homo sapiens_hsa006201.07814685
46Chronic myeloid leukemia_Homo sapiens_hsa052201.07280088
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05485737
48Axon guidance_Homo sapiens_hsa043601.03964275
49Insulin resistance_Homo sapiens_hsa049311.02480768
50Pathways in cancer_Homo sapiens_hsa052001.00381835
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98724753
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97857823
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.95543475
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94482605
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90347530
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90010856
57PPAR signaling pathway_Homo sapiens_hsa033200.88421866
58Fatty acid elongation_Homo sapiens_hsa000620.86928934
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.85942761
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85894652
61Melanoma_Homo sapiens_hsa052180.84832908
62Steroid biosynthesis_Homo sapiens_hsa001000.84710402
63Butanoate metabolism_Homo sapiens_hsa006500.84474176
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83422634
65Rap1 signaling pathway_Homo sapiens_hsa040150.82747987
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81621809
67Thyroid cancer_Homo sapiens_hsa052160.80734432
68Chemical carcinogenesis_Homo sapiens_hsa052040.79256031
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78551464
70AMPK signaling pathway_Homo sapiens_hsa041520.77184423
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77148978
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77045468
73Pancreatic cancer_Homo sapiens_hsa052120.77000425
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75851478
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75450746
76VEGF signaling pathway_Homo sapiens_hsa043700.74751988
77Mineral absorption_Homo sapiens_hsa049780.73649601
78HIF-1 signaling pathway_Homo sapiens_hsa040660.73490345
79Galactose metabolism_Homo sapiens_hsa000520.72463876
80Insulin signaling pathway_Homo sapiens_hsa049100.71403277
81ABC transporters_Homo sapiens_hsa020100.70552261
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.70045568
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68147839
84Colorectal cancer_Homo sapiens_hsa052100.66968819
85Prostate cancer_Homo sapiens_hsa052150.65612241
86Ovarian steroidogenesis_Homo sapiens_hsa049130.65419800
87HTLV-I infection_Homo sapiens_hsa051660.63864640
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63665938
89Tryptophan metabolism_Homo sapiens_hsa003800.63411467
90Hepatitis C_Homo sapiens_hsa051600.63040337
91Dorso-ventral axis formation_Homo sapiens_hsa043200.61804165
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61282484
93Toxoplasmosis_Homo sapiens_hsa051450.60016600
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.59555263
95beta-Alanine metabolism_Homo sapiens_hsa004100.58886772
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58582437
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58027970
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.57318337
99Prolactin signaling pathway_Homo sapiens_hsa049170.57072932
100Phenylalanine metabolism_Homo sapiens_hsa003600.55827754
101Fructose and mannose metabolism_Homo sapiens_hsa000510.55007084
102Sphingolipid metabolism_Homo sapiens_hsa006000.54321622
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54157928
104Glutathione metabolism_Homo sapiens_hsa004800.54105031
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.53542134
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.52756855
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52113214
108Arginine and proline metabolism_Homo sapiens_hsa003300.51277024
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51087425
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49805669
111Acute myeloid leukemia_Homo sapiens_hsa052210.49352717
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48626398
113Estrogen signaling pathway_Homo sapiens_hsa049150.48540277
114Glioma_Homo sapiens_hsa052140.47955358
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47838359
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47473588
117Oxytocin signaling pathway_Homo sapiens_hsa049210.47342466
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44781123
119Non-small cell lung cancer_Homo sapiens_hsa052230.44676203
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44544151
121p53 signaling pathway_Homo sapiens_hsa041150.44421370
122Pentose phosphate pathway_Homo sapiens_hsa000300.44308089
123Glucagon signaling pathway_Homo sapiens_hsa049220.43903226
124Ras signaling pathway_Homo sapiens_hsa040140.43879367
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42421121
126Linoleic acid metabolism_Homo sapiens_hsa005910.42295806
127mTOR signaling pathway_Homo sapiens_hsa041500.42225770
128GnRH signaling pathway_Homo sapiens_hsa049120.41591123
129Endocytosis_Homo sapiens_hsa041440.41421933
130Caffeine metabolism_Homo sapiens_hsa002320.40411271
131FoxO signaling pathway_Homo sapiens_hsa040680.40305690
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40200416
133ErbB signaling pathway_Homo sapiens_hsa040120.39279077
134Parkinsons disease_Homo sapiens_hsa050120.38826629
135Gastric acid secretion_Homo sapiens_hsa049710.36782957
136Bile secretion_Homo sapiens_hsa049760.36464753
137Peroxisome_Homo sapiens_hsa041460.35717095

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