IRX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.30339882
2sarcomere organization (GO:0045214)8.91660518
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.44182061
4myofibril assembly (GO:0030239)7.90547099
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.71051783
6cardiac muscle contraction (GO:0060048)6.96373614
7cardiac muscle cell development (GO:0055013)6.87690529
8keratinocyte proliferation (GO:0043616)6.84504552
9muscle filament sliding (GO:0030049)6.74446562
10actin-myosin filament sliding (GO:0033275)6.74446562
11establishment of skin barrier (GO:0061436)6.73574703
12regulation of water loss via skin (GO:0033561)6.65332250
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.63752953
14cardiac cell development (GO:0055006)6.49981230
15ventricular cardiac muscle cell action potential (GO:0086005)6.47200350
16ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.42969642
17cardiac muscle tissue morphogenesis (GO:0055008)6.35835512
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.28531502
19cell-substrate junction assembly (GO:0007044)6.28231694
20adult heart development (GO:0007512)6.14909069
21regulation of actin filament-based movement (GO:1903115)5.99950065
22tricarboxylic acid cycle (GO:0006099)5.99514661
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.90878047
24heart trabecula formation (GO:0060347)5.80963773
25actomyosin structure organization (GO:0031032)5.79410176
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.77677575
27cardiac muscle hypertrophy (GO:0003300)5.69622315
28muscle tissue morphogenesis (GO:0060415)5.67992286
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.67329483
30actin-mediated cell contraction (GO:0070252)5.63650839
31regulation of sarcomere organization (GO:0060297)5.61086130
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.48700032
33striated muscle hypertrophy (GO:0014897)5.43559010
34regulation of relaxation of muscle (GO:1901077)5.32018465
35plasma membrane repair (GO:0001778)5.27630604
36regulation of the force of heart contraction (GO:0002026)5.25248653
37heart process (GO:0003015)5.24484497
38heart contraction (GO:0060047)5.24484497
39keratinization (GO:0031424)5.20637599
40negative regulation of keratinocyte proliferation (GO:0010839)5.15946965
41cardiac right ventricle morphogenesis (GO:0003215)5.15143410
42regulation of cardioblast differentiation (GO:0051890)5.13022656
43negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.12036362
44striated muscle contraction (GO:0006941)5.09625577
45cell communication involved in cardiac conduction (GO:0086065)4.99373504
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.92435037
47atrioventricular valve morphogenesis (GO:0003181)4.91817319
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.90553520
49regulation of striated muscle contraction (GO:0006942)4.87818437
50negative regulation of striated muscle cell apoptotic process (GO:0010664)4.86084364
51regulation of membrane repolarization (GO:0060306)4.84030400
52muscle hypertrophy (GO:0014896)4.79604405
53desmosome organization (GO:0002934)4.75311270
54intermediate filament organization (GO:0045109)4.74663301
55gap junction assembly (GO:0016264)4.74459836
56regulation of skeletal muscle contraction (GO:0014819)4.67547115
57molting cycle (GO:0042303)4.64317364
58hair cycle (GO:0042633)4.64317364
59energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63398208
60ATP synthesis coupled proton transport (GO:0015986)4.63398208
61epidermis development (GO:0008544)4.61327928
62ventricular cardiac muscle cell development (GO:0055015)4.54545976
63regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.48898739
64carnitine shuttle (GO:0006853)4.44412867
65cardiac muscle cell action potential involved in contraction (GO:0086002)4.42515851
66epithelial cell-cell adhesion (GO:0090136)4.39472960
67heart valve formation (GO:0003188)4.37691798
68cardiac muscle cell action potential (GO:0086001)4.32707443
69regulation of heart rate (GO:0002027)4.31452682
70multicellular organismal water homeostasis (GO:0050891)4.28444285
71cell communication by electrical coupling (GO:0010644)4.28313101
72regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.25573439
73actin filament-based movement (GO:0030048)4.24767827
74regulation of cell communication by electrical coupling (GO:0010649)4.20136921
75regulation of cardiac muscle cell contraction (GO:0086004)4.18140718
76cardiac muscle adaptation (GO:0014887)4.15685065
77cardiac muscle hypertrophy in response to stress (GO:0014898)4.15685065
78muscle hypertrophy in response to stress (GO:0003299)4.15685065
79regulation of hair follicle development (GO:0051797)4.15125537
80planar cell polarity pathway involved in neural tube closure (GO:0090179)4.12602445
81negative regulation of potassium ion transport (GO:0043267)4.11428558
82negative regulation of protein localization to cell surface (GO:2000009)4.10432176
83trabecula formation (GO:0060343)4.08981412
84regulation of cardiac muscle contraction (GO:0055117)4.08311632
85regulation of acyl-CoA biosynthetic process (GO:0050812)4.06513232
86respiratory electron transport chain (GO:0022904)3.98477820
87heart valve morphogenesis (GO:0003179)3.98275146
88oxidative phosphorylation (GO:0006119)3.98151100
89dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.91859144
90renal system development (GO:0072001)3.90460661
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.90066316
92positive regulation of epidermis development (GO:0045684)3.89810037
93regulation of heart rate by cardiac conduction (GO:0086091)3.89638845
94cardiac conduction (GO:0061337)3.89346932
95positive regulation of epidermal cell differentiation (GO:0045606)3.87896319
96regulation of keratinocyte proliferation (GO:0010837)3.87582034
97electron transport chain (GO:0022900)3.87118107
98regulation of striated muscle cell apoptotic process (GO:0010662)3.84577349
99regulation of heart contraction (GO:0008016)3.81997038
100keratinocyte differentiation (GO:0030216)3.81277293
101regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.80772537
102fatty acid transmembrane transport (GO:1902001)3.79753909
103polarized epithelial cell differentiation (GO:0030859)3.78731862
104regulation of coenzyme metabolic process (GO:0051196)3.77084773
105regulation of cofactor metabolic process (GO:0051193)3.77084773
106regulation of ATP catabolic process (GO:1903289)3.74775775
107regulation of ATPase activity (GO:0043462)3.74775775
108striated muscle cell development (GO:0055002)3.73723246
109relaxation of cardiac muscle (GO:0055119)3.72557172
110establishment of planar polarity (GO:0001736)3.70375527
111establishment of tissue polarity (GO:0007164)3.70375527
112sarcoplasmic reticulum calcium ion transport (GO:0070296)3.68013648
113cardiac chamber formation (GO:0003207)3.67445008
114outflow tract septum morphogenesis (GO:0003148)3.62808540
115response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.59862183
116atrial septum morphogenesis (GO:0060413)3.50612246
117positive regulation of hair follicle development (GO:0051798)3.47416533
118positive regulation of hair cycle (GO:0042635)3.47416533
119peptidyl-tyrosine autophosphorylation (GO:0038083)3.47012465
120potassium ion export (GO:0071435)3.46034973
121keratinocyte development (GO:0003334)3.44991571
122positive regulation of keratinocyte differentiation (GO:0045618)3.42641599
123apoptotic process involved in morphogenesis (GO:0060561)3.41482988
124water homeostasis (GO:0030104)3.40213651
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.38905278
126ectoderm development (GO:0007398)3.37638741
127epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36419969
128positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.33409881
129negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32575715
130cytoskeletal anchoring at plasma membrane (GO:0007016)3.31118831
131NADH metabolic process (GO:0006734)3.29389416
132focal adhesion assembly (GO:0048041)3.29369670
133cell-substrate adherens junction assembly (GO:0007045)3.29369670
134cardiac muscle tissue development (GO:0048738)3.28592565
135positive regulation of heart contraction (GO:0045823)3.26320306
136regulation of cardiac muscle cell apoptotic process (GO:0010665)3.25294478
137muscle cell development (GO:0055001)3.22542890
138regulation of muscle contraction (GO:0006937)3.22297804
1392-oxoglutarate metabolic process (GO:0006103)3.22143448
140carnitine transmembrane transport (GO:1902603)3.18948775
141regulation of epidermis development (GO:0045682)3.18779545
142adherens junction assembly (GO:0034333)3.17699182
143endocardial cushion morphogenesis (GO:0003203)3.14953574
144striated muscle adaptation (GO:0014888)3.14886372
145mammary gland epithelial cell differentiation (GO:0060644)3.13295701
146regulation of hair cycle (GO:0042634)3.12496414
147surfactant homeostasis (GO:0043129)3.09618295
148epidermal cell differentiation (GO:0009913)3.08050449
149asymmetric protein localization (GO:0008105)3.07518097
150apical protein localization (GO:0045176)3.03967098
151negative regulation of cell fate specification (GO:0009996)2.97880545
152skin development (GO:0043588)2.96161367
153establishment of apical/basal cell polarity (GO:0035089)2.95649837
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.92330677
155ventricular trabecula myocardium morphogenesis (GO:0003222)2.91230822
156intermediate filament cytoskeleton organization (GO:0045104)2.90817470
157regulation of transforming growth factor beta2 production (GO:0032909)2.88185757
158negative regulation of epidermis development (GO:0045683)2.87258832
159chemical homeostasis within a tissue (GO:0048875)2.85154808
160cell junction assembly (GO:0034329)2.84848643
161hair follicle development (GO:0001942)2.81338800
162Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79660369
163morphogenesis of embryonic epithelium (GO:0016331)2.78431970
164intermediate filament-based process (GO:0045103)2.76754369
165regulation of epidermal cell differentiation (GO:0045604)2.71825175
166cell junction organization (GO:0034330)2.67476807
167regulation of establishment of planar polarity (GO:0090175)2.66065733
168negative regulation of chondrocyte differentiation (GO:0032331)2.62475239
169endodermal cell differentiation (GO:0035987)2.61278540
170adherens junction organization (GO:0034332)2.61177575
171regulation of tight junction assembly (GO:2000810)2.60987478
172regulation of keratinocyte differentiation (GO:0045616)2.58581706
173semaphorin-plexin signaling pathway (GO:0071526)2.58043490
174COPI coating of Golgi vesicle (GO:0048205)2.56959933
175hemidesmosome assembly (GO:0031581)14.3510684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.33301378
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.04711045
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.24857406
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.17983185
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.11619997
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.98149172
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.98149172
8ZNF263_19887448_ChIP-Seq_K562_Human3.71679705
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.53444348
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42067550
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.24084474
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.20072703
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.85277699
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.72095912
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64640600
16GATA4_21415370_ChIP-Seq_HL-1_Mouse2.25583921
17AR_21909140_ChIP-Seq_LNCAP_Human2.07437395
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.99733976
19* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93263676
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93263676
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80469191
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.75032023
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.68693757
24ISL1_27105846_Chip-Seq_CPCs_Mouse1.68072916
25NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.67857915
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67448997
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67081824
28CLOCK_20551151_ChIP-Seq_293T_Human1.64994085
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64559450
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.64032453
31* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62324463
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61173114
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58506508
34* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56587228
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53370928
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53229260
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52684634
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51508861
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49476856
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.41438607
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41020096
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40106521
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38189187
44* TP63_22573176_ChIP-Seq_HFKS_Human1.38083775
45KDM2B_26808549_Chip-Seq_DND41_Human1.35172187
46RACK7_27058665_Chip-Seq_MCF-7_Human1.33699965
47CTCF_27219007_Chip-Seq_Bcells_Human1.33468476
48LXR_22292898_ChIP-Seq_THP-1_Human1.31766665
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28863919
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28176456
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28040461
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24221865
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22091081
54* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21020978
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19869382
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19615976
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18718331
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18557544
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16939922
60* ATF3_27146783_Chip-Seq_COLON_Human1.16777741
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16048239
62CHD1_26751641_Chip-Seq_LNCaP_Human1.15530430
63* RUNX1_27514584_Chip-Seq_MCF-7_Human1.14366071
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11481600
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10844862
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09324225
67* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08633794
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08444042
69GATA1_19941826_ChIP-Seq_K562_Human1.06892870
70* SMC4_20622854_ChIP-Seq_HELA_Human1.06130812
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05845840
72CREB1_26743006_Chip-Seq_LNCaP_Human1.03901627
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03782032
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02665857
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01431060
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.00262886
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.00069087
78* KLF5_25053715_ChIP-Seq_YYC3_Human0.99714076
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99451655
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99244724
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98837840
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98788207
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98704983
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98386544
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98202233
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.97462730
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97287986
88KDM2B_26808549_Chip-Seq_K562_Human0.95945040
89* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95721883
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.94118851
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93591226
92TCF7_22412390_ChIP-Seq_EML_Mouse0.93534806
93GATA3_24758297_ChIP-Seq_MCF-7_Human0.93487270
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92478451
95* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92331599
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92266900
97FOXM1_23109430_ChIP-Seq_U2OS_Human0.92036128
98SPI1_20517297_ChIP-Seq_HL60_Human0.91938751
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91366577
100TP53_22127205_ChIP-Seq_IMR90_Human0.91179209
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91031534
102SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91006434
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90978622
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.90896574
105ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90202595
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.90095345
107* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89352588
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89149391
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88294010
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.87808377
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87559317
112* P68_20966046_ChIP-Seq_HELA_Human0.87299138
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87231623
114CJUN_26792858_Chip-Seq_BT549_Human0.86884083
115* EZH2_27304074_Chip-Seq_ESCs_Mouse0.86074961
116* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86036188
117* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86036188
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85453131
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85066451
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.84911138
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.84730634
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.83515164
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83492033
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.83345074
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82323890
126GATA6_25053715_ChIP-Seq_YYC3_Human0.81012743
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.80552463
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80043246
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78326302
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77534028
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77384210
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76776718
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76745730
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76440656
135LXR_22158963_ChIP-Seq_LIVER_Mouse0.76417096
136BCOR_27268052_Chip-Seq_Bcells_Human0.76045064
137MYC_19079543_ChIP-ChIP_MESCs_Mouse0.75802099
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75085429
139* UBF1/2_26484160_Chip-Seq_HMECs_Human0.74651339
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74157283
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73977340
142* EZH2_27294783_Chip-Seq_ESCs_Mouse0.73909943
143ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73879096
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73548911
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73469720
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.73361592
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73119150
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72481316
149CTCF_21964334_Chip-Seq_Bcells_Human0.71784761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.43070767
2MP0002837_dystrophic_cardiac_calcinosis6.27864029
3MP0010234_abnormal_vibrissa_follicle5.23800764
4MP0004215_abnormal_myocardial_fiber4.82717310
5MP0000751_myopathy4.64261831
6MP0003646_muscle_fatigue4.46975367
7MP0004036_abnormal_muscle_relaxation4.38721802
8* MP0005330_cardiomyopathy3.94901058
9MP0000749_muscle_degeneration3.63347475
10* MP0002972_abnormal_cardiac_muscle3.33351845
11MP0008775_abnormal_heart_ventricle3.21268523
12MP0003137_abnormal_impulse_conducting3.17687238
13MP0004087_abnormal_muscle_fiber2.96110482
14MP0010678_abnormal_skin_adnexa2.86402744
15MP0005385_cardiovascular_system_phenoty2.81267785
16MP0001544_abnormal_cardiovascular_syste2.81267785
17MP0010630_abnormal_cardiac_muscle2.81233327
18MP0004381_abnormal_hair_follicle2.80467854
19MP0000566_synostosis2.72994930
20MP0005409_darkened_coat_color2.72164515
21MP0006138_congestive_heart_failure2.70384867
22MP0001216_abnormal_epidermal_layer2.61213363
23MP0003828_pulmonary_edema2.59523324
24MP0003453_abnormal_keratinocyte_physiol2.58867095
25* MP0005620_abnormal_muscle_contractility2.57230745
26MP0000750_abnormal_muscle_regeneration2.54144458
27MP0004484_altered_response_of2.30478212
28MP0004085_abnormal_heartbeat2.28868350
29MP0002106_abnormal_muscle_physiology2.23116124
30MP0000377_abnormal_hair_follicle2.13684426
31MP0000537_abnormal_urethra_morphology2.04508110
32MP0002269_muscular_atrophy2.01983106
33MP0001849_ear_inflammation2.01410762
34MP0003950_abnormal_plasma_membrane2.01188994
35MP0004130_abnormal_muscle_cell2.00223533
36MP0003221_abnormal_cardiomyocyte_apopto1.98640657
37MP0002127_abnormal_cardiovascular_syste1.94770391
38MP0010771_integument_phenotype1.90910732
39MP0004510_myositis1.81973498
40MP0005369_muscle_phenotype1.77930389
41MP0003567_abnormal_fetal_cardiomyocyte1.77875676
42MP0004145_abnormal_muscle_electrophysio1.72182559
43MP0004264_abnormal_extraembryonic_tissu1.70581325
44MP0002234_abnormal_pharynx_morphology1.69620207
45MP0000759_abnormal_skeletal_muscle1.65137144
46MP0003705_abnormal_hypodermis_morpholog1.58904052
47MP0009053_abnormal_anal_canal1.56345810
48MP0004233_abnormal_muscle_weight1.51704416
49MP0000747_muscle_weakness1.49244778
50MP0004858_abnormal_nervous_system1.44978595
51MP0006036_abnormal_mitochondrial_physio1.44128021
52MP0000427_abnormal_hair_cycle1.38836412
53MP0005076_abnormal_cell_differentiation1.29356180
54MP0009931_abnormal_skin_appearance1.28076374
55MP0005451_abnormal_body_composition1.27570594
56MP0003279_aneurysm1.26195754
57* MP0000266_abnormal_heart_morphology1.25243067
58MP0000647_abnormal_sebaceous_gland1.24005885
59MP0005275_abnormal_skin_tensile1.23838148
60MP0000579_abnormal_nail_morphology1.22883368
61MP0003566_abnormal_cell_adhesion1.21810487
62MP0005023_abnormal_wound_healing1.20393014
63MP0003315_abnormal_perineum_morphology1.18883537
64MP0005666_abnormal_adipose_tissue1.17569492
65MP0004272_abnormal_basement_membrane1.17486934
66MP0000678_abnormal_parathyroid_gland1.17334074
67MP0002332_abnormal_exercise_endurance1.16804041
68MP0010368_abnormal_lymphatic_system1.15600341
69MP0000462_abnormal_digestive_system1.12400902
70MP0000627_abnormal_mammary_gland1.11967946
71MP0002249_abnormal_larynx_morphology1.08982920
72MP0004782_abnormal_surfactant_physiolog1.00645550
73MP0000343_altered_response_to0.97877445
74MP0005670_abnormal_white_adipose0.97771688
75MP0000367_abnormal_coat/_hair0.97331785
76MP0005165_increased_susceptibility_to0.94767667
77MP0005623_abnormal_meninges_morphology0.94031870
78MP0000538_abnormal_urinary_bladder0.89664638
79MP0002089_abnormal_postnatal_growth/wei0.87933499
80MP0002697_abnormal_eye_size0.87816930
81MP0004185_abnormal_adipocyte_glucose0.87649189
82MP0008260_abnormal_autophagy0.87360274
83MP0002128_abnormal_blood_circulation0.86440744
84MP0009379_abnormal_foot_pigmentation0.86277547
85MP0005257_abnormal_intraocular_pressure0.86054380
86MP0006035_abnormal_mitochondrial_morpho0.85335470
87MP0004947_skin_inflammation0.85130805
88MP0005375_adipose_tissue_phenotype0.84299202
89MP0001191_abnormal_skin_condition0.84297653
90MP0003755_abnormal_palate_morphology0.80455884
91MP0003941_abnormal_skin_development0.80371850
92MP0008438_abnormal_cutaneous_collagen0.78545504
93MP0001340_abnormal_eyelid_morphology0.76852901
94MP0002111_abnormal_tail_morphology0.75211280
95MP0001879_abnormal_lymphatic_vessel0.72427498
96MP0000230_abnormal_systemic_arterial0.71251888
97MP0004197_abnormal_fetal_growth/weight/0.70721965
98MP0009780_abnormal_chondrocyte_physiolo0.69940997
99MP0000767_abnormal_smooth_muscle0.69546584
100MP0010352_gastrointestinal_tract_polyps0.65456160
101MP0002108_abnormal_muscle_morphology0.65296430
102MP0000013_abnormal_adipose_tissue0.64307445
103MP0002925_abnormal_cardiovascular_devel0.63957096
104MP0001299_abnormal_eye_distance/0.62730911
105MP0002796_impaired_skin_barrier0.62598017
106MP0009384_cardiac_valve_regurgitation0.62486389
107MP0001243_abnormal_dermal_layer0.61862839
108MP0003136_yellow_coat_color0.61764385
109MP0002088_abnormal_embryonic_growth/wei0.59944327
110MP0003984_embryonic_growth_retardation0.59805820
111MP0001784_abnormal_fluid_regulation0.59753386
112MP0008932_abnormal_embryonic_tissue0.59473305
113MP0002896_abnormal_bone_mineralization0.59258647
114MP0000762_abnormal_tongue_morphology0.59187542
115MP0005266_abnormal_metabolism0.59132520
116MP0001730_embryonic_growth_arrest0.56357876
117MP0000003_abnormal_adipose_tissue0.55974582
118MP0001881_abnormal_mammary_gland0.55962608
119MP0003693_abnormal_embryo_hatching0.55870958
120MP0003878_abnormal_ear_physiology0.55306078
121MP0005377_hearing/vestibular/ear_phenot0.55306078
122MP0004134_abnormal_chest_morphology0.55092281
123MP0002086_abnormal_extraembryonic_tissu0.54660899
124MP0009672_abnormal_birth_weight0.54609125
125MP0000733_abnormal_muscle_development0.53022930
126MP0000432_abnormal_head_morphology0.52833812
127MP0003122_maternal_imprinting0.51143990
128MP0000534_abnormal_ureter_morphology0.49618245
129MP0004957_abnormal_blastocyst_morpholog0.49446822
130MP0005187_abnormal_penis_morphology0.49042100
131MP0001661_extended_life_span0.48048351
132MP0001614_abnormal_blood_vessel0.45811368
133MP0002909_abnormal_adrenal_gland0.44675184
134MP0002060_abnormal_skin_morphology0.43986533
135MP0002098_abnormal_vibrissa_morphology0.41023249
136MP0005380_embryogenesis_phenotype0.38061267
137MP0001672_abnormal_embryogenesis/_devel0.38061267
138MP0000467_abnormal_esophagus_morphology0.37583821
139MP0003385_abnormal_body_wall0.35690709
140MP0003806_abnormal_nucleotide_metabolis0.34802389
141MP0003935_abnormal_craniofacial_develop0.32880480
142MP0008961_abnormal_basal_metabolism0.31616516
143MP0005319_abnormal_enzyme/_coenzyme0.31379459
144MP0000383_abnormal_hair_follicle0.29372228
145MP0003948_abnormal_gas_homeostasis0.28926581
146MP0001727_abnormal_embryo_implantation0.27785570
147MP0006054_spinal_hemorrhage0.27526329
148MP0010030_abnormal_orbit_morphology0.27118701
149MP0000428_abnormal_craniofacial_morphol0.26452368
150MP0004043_abnormal_pH_regulation0.26266920
151MP0005388_respiratory_system_phenotype0.25621826
152MP0002133_abnormal_respiratory_system0.25621826
153MP0005503_abnormal_tendon_morphology0.24315325
154MP0005501_abnormal_skin_physiology0.21769645
155MP0002078_abnormal_glucose_homeostasis0.21460566

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.83792263
2Ventricular tachycardia (HP:0004756)7.41675379
3Fragile nails (HP:0001808)7.31743079
4Onycholysis (HP:0001806)7.29208151
5Abnormality of nail color (HP:0100643)7.00617969
6Plantar hyperkeratosis (HP:0007556)6.84451228
7Atrial fibrillation (HP:0005110)6.41530246
8Subaortic stenosis (HP:0001682)6.05291532
9Abnormality of the left ventricular outflow tract (HP:0011103)6.05291532
10Primary atrial arrhythmia (HP:0001692)5.99123607
11Supraventricular tachycardia (HP:0004755)5.79667764
12Right ventricular cardiomyopathy (HP:0011663)5.75068218
13Supraventricular arrhythmia (HP:0005115)5.70521094
14Calf muscle hypertrophy (HP:0008981)5.60993029
15Lipoatrophy (HP:0100578)5.55707021
16Atrophic scars (HP:0001075)5.45988202
17Exercise-induced muscle cramps (HP:0003710)5.38047145
18Syncope (HP:0001279)5.37756509
19Abnormality of the calf musculature (HP:0001430)5.21660238
20Thick nail (HP:0001805)5.18483500
21Pili torti (HP:0003777)5.15317557
22Palmoplantar hyperkeratosis (HP:0000972)5.08296205
23Muscle fiber splitting (HP:0003555)5.00963855
24Muscle hypertrophy of the lower extremities (HP:0008968)4.99618945
25Alopecia of scalp (HP:0002293)4.93461396
26Exercise-induced myalgia (HP:0003738)4.87722397
27Prolonged QT interval (HP:0001657)4.87637168
28Palmar hyperkeratosis (HP:0010765)4.79084509
29Ventricular arrhythmia (HP:0004308)4.68023185
30Nail dystrophy (HP:0008404)4.64752789
31Hyporeflexia of lower limbs (HP:0002600)4.63507590
32Palpitations (HP:0001962)4.61324497
33Dilated cardiomyopathy (HP:0001644)4.47903196
34Ventricular fibrillation (HP:0001663)4.46344433
35Bundle branch block (HP:0011710)4.40816322
36Asymmetric septal hypertrophy (HP:0001670)4.37361338
37Hypotrichosis (HP:0001006)4.14513869
38Ridged nail (HP:0001807)4.06585218
39Myoglobinuria (HP:0002913)4.00277694
40EMG: myopathic abnormalities (HP:0003458)3.88187036
41Heart block (HP:0012722)3.69287785
42Increased connective tissue (HP:0009025)3.65458401
43Atrioventricular block (HP:0001678)3.62475098
44Pterygium (HP:0001059)3.61464363
45Abnormal hair laboratory examination (HP:0003328)3.60952161
46Abnormal atrioventricular conduction (HP:0005150)3.56514658
47Abnormal blistering of the skin (HP:0008066)3.54280050
48Abnormal EKG (HP:0003115)3.48388446
49Woolly hair (HP:0002224)3.40553191
50Aplasia cutis congenita (HP:0001057)3.29335469
51Lip pit (HP:0100267)3.25095373
52Hypoplasia of dental enamel (HP:0006297)3.22986827
53Broad face (HP:0000283)3.16154202
54Fragile skin (HP:0001030)3.15919461
55Advanced eruption of teeth (HP:0006288)3.15449792
56Palmoplantar keratoderma (HP:0000982)3.12098291
57Conjunctival hamartoma (HP:0100780)3.10902794
58Depressed nasal tip (HP:0000437)3.08935892
59Ragged-red muscle fibers (HP:0003200)3.04206947
60Sparse scalp hair (HP:0002209)3.03263418
61Natal tooth (HP:0000695)2.99423031
62Rhabdomyolysis (HP:0003201)2.99070383
63Acute necrotizing encephalopathy (HP:0006965)2.98901856
64Abnormal mitochondria in muscle tissue (HP:0008316)2.98705505
65Abnormality of the salivary glands (HP:0010286)2.97420161
66Left ventricular hypertrophy (HP:0001712)2.96738842
67Sparse eyelashes (HP:0000653)2.95987517
68Myotonia (HP:0002486)2.93044480
69Selective tooth agenesis (HP:0001592)2.81086606
70Hepatic necrosis (HP:0002605)2.73271967
71Congenital malformation of the right heart (HP:0011723)2.65845137
72Double outlet right ventricle (HP:0001719)2.65845137
73Type 1 muscle fiber predominance (HP:0003803)2.64343096
74Distal lower limb muscle weakness (HP:0009053)2.60553855
75Septate vagina (HP:0001153)2.58936759
76Acute encephalopathy (HP:0006846)2.49749636
77Oral leukoplakia (HP:0002745)2.46796858
78Ankyloglossia (HP:0010296)2.45639980
79Difficulty running (HP:0009046)2.44991385
80Abnormality of secondary sexual hair (HP:0009888)2.44517125
81Abnormality of the axillary hair (HP:0100134)2.44517125
82Anonychia (HP:0001798)2.42033963
83Absent eyelashes (HP:0000561)2.41998492
84Progressive macrocephaly (HP:0004481)2.41561921
85Sudden cardiac death (HP:0001645)2.40137537
86Amelogenesis imperfecta (HP:0000705)2.40095745
87Congenital ichthyosiform erythroderma (HP:0007431)2.37810966
88Mildly elevated creatine phosphokinase (HP:0008180)2.35924042
89Hamartoma of the eye (HP:0010568)2.35503236
90Difficulty climbing stairs (HP:0003551)2.35423158
91Abnormality of the neuromuscular junction (HP:0003398)2.34379202
92Fatigable weakness (HP:0003473)2.34379202
93Hepatocellular necrosis (HP:0001404)2.32881245
94Ketoacidosis (HP:0001993)2.32337970
95Neck muscle weakness (HP:0000467)2.32323374
96Hypoglycemic coma (HP:0001325)2.29839450
97Mitochondrial inheritance (HP:0001427)2.27509316
98Laryngomalacia (HP:0001601)2.18770459
99Popliteal pterygium (HP:0009756)2.17519091
100Cerebral edema (HP:0002181)2.17339472
101Dry hair (HP:0011359)2.16856214
102Increased CSF lactate (HP:0002490)2.16680919
103Neoplasm of the adrenal gland (HP:0100631)2.15399545
104Corneal erosion (HP:0200020)2.12579008
105Pheochromocytoma (HP:0002666)2.11204349
106Lymphangioma (HP:0100764)2.10899258
107Increased variability in muscle fiber diameter (HP:0003557)2.09754974
108Limb-girdle muscle atrophy (HP:0003797)2.08338064
109Congestive heart failure (HP:0001635)2.08059433
110Hypoplastic left heart (HP:0004383)2.07660429
111Abnormality of the foot musculature (HP:0001436)2.06181280
112Dicarboxylic aciduria (HP:0003215)2.03649241
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03649241
114Exercise intolerance (HP:0003546)2.03507945
115Hypoplastic labia majora (HP:0000059)2.02766677
116Areflexia of lower limbs (HP:0002522)2.02233302
117Erythema (HP:0010783)2.01289178
118EMG: neuropathic changes (HP:0003445)2.00853391
119Carious teeth (HP:0000670)1.98470358
120Hypodontia (HP:0000668)1.96567945
121Pulmonary artery stenosis (HP:0004415)1.95246974
122Centrally nucleated skeletal muscle fibers (HP:0003687)1.95170718
123Muscle stiffness (HP:0003552)1.95103450
124Ectropion (HP:0000656)1.94640242
125Abnormality of fatty-acid metabolism (HP:0004359)1.93087940
126Oligodontia (HP:0000677)1.92990133
127Abnormality of the tricuspid valve (HP:0001702)1.92586500
128Esophageal atresia (HP:0002032)1.91496518
129Increased muscle lipid content (HP:0009058)1.89448696
130Flat acetabular roof (HP:0003180)1.89346224
131Milia (HP:0001056)1.89289095
132Respiratory failure (HP:0002878)1.89100360
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.88768757
134Down-sloping shoulders (HP:0200021)1.85623105
135Abnormality of oral frenula (HP:0000190)1.83155813
136Lactic acidosis (HP:0003128)1.82671059
137Neuroendocrine neoplasm (HP:0100634)1.81809746
138Abnormality of skeletal muscle fiber size (HP:0012084)1.80793414
139Esophageal neoplasm (HP:0100751)1.80632021
140Neoplasm of head and neck (HP:0012288)1.80632021
141Abnormality of the labia majora (HP:0012881)1.80004163
142Blepharitis (HP:0000498)1.78794194
143Thin bony cortex (HP:0002753)1.77973338
144Skin pits (HP:0100276)1.77824823
145Scapular winging (HP:0003691)1.76720077
146Patent foramen ovale (HP:0001655)1.76342503
147Generalized muscle weakness (HP:0003324)1.74503773
148Multiple enchondromatosis (HP:0005701)1.73166280
149Nasolacrimal duct obstruction (HP:0000579)1.72636606
150Large for gestational age (HP:0001520)1.70712375
151Foot dorsiflexor weakness (HP:0009027)1.69229444
152Hyperhidrosis (HP:0000975)1.68622326
153Abnormality of permanent molar morphology (HP:0011071)1.67315447
154Abnormality of the dental root (HP:0006486)1.67315447
155Taurodontia (HP:0000679)1.67315447
156Amniotic constriction ring (HP:0009775)1.67150863
157Abnormality of placental membranes (HP:0011409)1.67150863
158Broad metatarsal (HP:0001783)1.66714041
159Sparse lateral eyebrow (HP:0005338)1.65390043
160Distal lower limb amyotrophy (HP:0008944)1.65356009
161Deviation of the thumb (HP:0009603)1.64912009
162Increased intramyocellular lipid droplets (HP:0012240)1.64794674
163Testicular atrophy (HP:0000029)1.64393504
164Periauricular skin pits (HP:0100277)1.64089702
165Preauricular pit (HP:0004467)1.64089702
166Diaphragmatic weakness (HP:0009113)1.63645382
167Neonatal death (HP:0003811)1.62166742
168Trismus (HP:0000211)1.59825323
169Follicular hyperkeratosis (HP:0007502)1.59777200
170Abnormal ossification of hand bones (HP:0005921)1.59026168
171Breast hypoplasia (HP:0003187)1.54560913
172Abnormality of the lacrimal duct (HP:0011481)1.54446828
173Abnormality of molar (HP:0011077)1.54376403
174Abnormality of molar morphology (HP:0011070)1.54376403
175Abnormality of the fingernails (HP:0001231)1.53934559
176Vertebral clefting (HP:0008428)1.53710189
177Absent hair (HP:0002298)1.52904749
178Erythroderma (HP:0001019)1.52748951
179Vertebral arch anomaly (HP:0008438)1.51348618
180Abnormal hand bone ossification (HP:0010660)1.48567373
181Neoplasm of the heart (HP:0100544)1.47648663
182Dehydration (HP:0001944)1.46680584
183Abnormality of the nasal septum (HP:0000419)1.46007073
184Hypohidrosis (HP:0000966)1.45703820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.64807313
2MYLK4.55039571
3PKN24.24775592
4OBSCN4.03739592
5EPHA23.84536660
6LMTK23.64060408
7TRIB33.25668783
8DMPK3.22975414
9PDK33.16312941
10PDK43.16312941
11PHKG23.10045707
12PHKG13.10045707
13STK243.07134459
14MST1R2.78070180
15ARAF2.77206594
16MET2.41916257
17PIK3CA2.40237543
18PIM22.38223845
19SMG12.36759290
20NEK12.31026546
21TSSK62.27856062
22TIE12.20515361
23PNCK2.18479554
24EEF2K2.12772257
25MAPK152.02072185
26MAP3K21.95659506
27BCKDK1.85360244
28PDK21.78610797
29ILK1.77210497
30STK38L1.68783360
31CDC42BPA1.66570992
32MUSK1.62231099
33CDK121.52633799
34PTK21.47489503
35PAK31.46139804
36PRKD11.42107093
37WNK41.37540480
38NTRK11.35994395
39RIPK11.30695676
40MAPKAPK31.27496164
41ROCK11.22202151
42PINK11.21964571
43CAMK2D1.21706888
44ZAK1.20893197
45CAMK1D1.20697000
46DAPK31.18534367
47STK41.16284450
48MAP3K61.13004165
49TRPM71.12586026
50EPHB21.12192175
51PAK41.11618011
52GRK71.11436829
53BRSK21.09738968
54CAMK1G1.08387013
55KSR21.07329981
56TESK11.05033218
57NME11.04988198
58MAP3K101.04830417
59PRKCI1.04231985
60FLT31.03848565
61BRAF1.02326308
62MAP3K91.02197575
63MAP3K70.99888827
64RAF10.93971265
65MAPK120.93436272
66MAP3K30.91122209
67PRKD20.88623216
68PTK2B0.83416905
69MAP3K50.81224297
70BRSK10.80211341
71PRKAA10.77556769
72STK380.76824931
73PRKAA20.74606159
74PDGFRA0.73374520
75CAMK40.72800690
76ICK0.68803130
77KDR0.67857955
78PKN10.67581008
79RPS6KC10.67482459
80RPS6KL10.67482459
81SCYL20.67274090
82MAP2K20.67216528
83ROCK20.66806352
84STK390.64816109
85WNK10.64631674
86IRAK30.61263388
87PBK0.57730889
88PTK60.57315252
89PRPF4B0.56464192
90RPS6KA60.55882015
91CAMK10.55258928
92SIK10.54841344
93LATS20.53677770
94FER0.53567182
95CAMK2A0.53297933
96NEK60.52847267
97TGFBR20.51220545
98WEE10.50324995
99LATS10.49655466
100CDK70.47121982
101PRKACB0.45754874
102INSRR0.45168433
103MARK20.44108612
104EIF2AK20.43892714
105EPHB10.43530280
106FGFR10.42140954
107RPS6KA40.41004266
108MAPKAPK50.40332659
109PRKACA0.39694370
110PRKCE0.39521957
111LRRK20.38904489
112AKT20.38607480
113ERN10.38005685
114PRKD30.37921644
115PRKG20.37613708
116AKT30.37301548
117BMX0.36512230
118MAP3K80.36399238
119LIMK10.35946384
120RPS6KA10.35149148
121PRKACG0.34879830
122MTOR0.33340970
123MAP2K30.32617322
124NME20.29312725
125TTK0.28946779
126UHMK10.26812278
127MAPKAPK20.26364269
128CHUK0.25912908
129RPS6KB10.25804005
130PDPK10.24902523
131RET0.24316719
132MAP3K110.23983393
133CAMK2G0.21903349
134AURKB0.21007629
135PDK10.19986239
136PAK20.18915399
137TGFBR10.18493554
138TAOK10.17996763
139RPS6KA20.16783823
140PRKCH0.15623330
141CDK40.14761325
142MAP3K10.13564475
143MAPK70.13361516
144RPS6KB20.12914214
145MARK30.12387056
146PRKG10.10329176
147MAPK110.09950781

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.86633731
2Cardiac muscle contraction_Homo sapiens_hsa042604.78859916
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.13879814
4Dilated cardiomyopathy_Homo sapiens_hsa054144.03135815
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.92328173
6Parkinsons disease_Homo sapiens_hsa050123.50013800
7Oxidative phosphorylation_Homo sapiens_hsa001903.37442387
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78765915
9Propanoate metabolism_Homo sapiens_hsa006402.77180881
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.62341840
11Alzheimers disease_Homo sapiens_hsa050102.54094826
12Fatty acid degradation_Homo sapiens_hsa000712.52248591
13Carbon metabolism_Homo sapiens_hsa012002.36418327
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31665034
15Huntingtons disease_Homo sapiens_hsa050162.24492695
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98057970
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86420806
18Fatty acid metabolism_Homo sapiens_hsa012121.85669549
19Viral myocarditis_Homo sapiens_hsa054161.77761880
20Thyroid cancer_Homo sapiens_hsa052161.77455362
21Steroid biosynthesis_Homo sapiens_hsa001001.61046110
22Pyruvate metabolism_Homo sapiens_hsa006201.59764236
23Bladder cancer_Homo sapiens_hsa052191.57708617
24ErbB signaling pathway_Homo sapiens_hsa040121.55358922
25Endometrial cancer_Homo sapiens_hsa052131.55165362
26Prion diseases_Homo sapiens_hsa050201.43766707
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42797427
28Axon guidance_Homo sapiens_hsa043601.36457677
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31992835
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27839640
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26718997
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23962129
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23689371
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22968468
35Fatty acid elongation_Homo sapiens_hsa000621.20304603
36MicroRNAs in cancer_Homo sapiens_hsa052061.20231800
37Biosynthesis of amino acids_Homo sapiens_hsa012301.12462911
38p53 signaling pathway_Homo sapiens_hsa041151.11914010
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11746320
40Butanoate metabolism_Homo sapiens_hsa006501.11635100
41Insulin resistance_Homo sapiens_hsa049311.04253751
42Acute myeloid leukemia_Homo sapiens_hsa052211.04138629
43Chronic myeloid leukemia_Homo sapiens_hsa052200.98291341
44Glucagon signaling pathway_Homo sapiens_hsa049220.95032385
45Focal adhesion_Homo sapiens_hsa045100.94201636
46Glioma_Homo sapiens_hsa052140.93179700
47Prostate cancer_Homo sapiens_hsa052150.92589024
48PPAR signaling pathway_Homo sapiens_hsa033200.88565834
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87947759
50ECM-receptor interaction_Homo sapiens_hsa045120.87899454
51HIF-1 signaling pathway_Homo sapiens_hsa040660.85660939
52Melanoma_Homo sapiens_hsa052180.85341555
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.84923107
54Tight junction_Homo sapiens_hsa045300.82362207
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80494263
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79691427
57Insulin signaling pathway_Homo sapiens_hsa049100.79077769
58Lysine degradation_Homo sapiens_hsa003100.77999540
59Starch and sucrose metabolism_Homo sapiens_hsa005000.75878396
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72357179
61Choline metabolism in cancer_Homo sapiens_hsa052310.70926653
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.70230805
63Vitamin digestion and absorption_Homo sapiens_hsa049770.69592364
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67140561
65Basal cell carcinoma_Homo sapiens_hsa052170.65817141
66Inositol phosphate metabolism_Homo sapiens_hsa005620.65727472
67Calcium signaling pathway_Homo sapiens_hsa040200.64843496
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64588851
69Non-small cell lung cancer_Homo sapiens_hsa052230.64521528
70Sphingolipid metabolism_Homo sapiens_hsa006000.63705514
71Wnt signaling pathway_Homo sapiens_hsa043100.60739364
72AMPK signaling pathway_Homo sapiens_hsa041520.60696522
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60695910
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59884147
75Galactose metabolism_Homo sapiens_hsa000520.57472751
76Pancreatic cancer_Homo sapiens_hsa052120.57278684
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.56747276
78Adherens junction_Homo sapiens_hsa045200.55998651
79Type II diabetes mellitus_Homo sapiens_hsa049300.55235247
80Tryptophan metabolism_Homo sapiens_hsa003800.55074306
81Oxytocin signaling pathway_Homo sapiens_hsa049210.54168363
82Amoebiasis_Homo sapiens_hsa051460.53908772
83beta-Alanine metabolism_Homo sapiens_hsa004100.52997219
84TGF-beta signaling pathway_Homo sapiens_hsa043500.52749532
85Pentose phosphate pathway_Homo sapiens_hsa000300.52271003
86Sulfur relay system_Homo sapiens_hsa041220.51272408
87Mineral absorption_Homo sapiens_hsa049780.50381751
88Arginine biosynthesis_Homo sapiens_hsa002200.47847261
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.47595719
90N-Glycan biosynthesis_Homo sapiens_hsa005100.47068873
91Phenylalanine metabolism_Homo sapiens_hsa003600.46932186
92Hedgehog signaling pathway_Homo sapiens_hsa043400.44311438
93Arginine and proline metabolism_Homo sapiens_hsa003300.44188881
94Cell cycle_Homo sapiens_hsa041100.43818354
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43672986
96mRNA surveillance pathway_Homo sapiens_hsa030150.43639611
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43453300
98Proteoglycans in cancer_Homo sapiens_hsa052050.43420356
99Oocyte meiosis_Homo sapiens_hsa041140.42014568
100cAMP signaling pathway_Homo sapiens_hsa040240.41945113
101Endocytosis_Homo sapiens_hsa041440.39794675
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38988189
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38790645
104Fatty acid biosynthesis_Homo sapiens_hsa000610.38587887
105Colorectal cancer_Homo sapiens_hsa052100.38538789
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38365080
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.37893280
108Protein digestion and absorption_Homo sapiens_hsa049740.35244865
109Renin secretion_Homo sapiens_hsa049240.34628634
110Fructose and mannose metabolism_Homo sapiens_hsa000510.34001536
111Peroxisome_Homo sapiens_hsa041460.33648937
112Small cell lung cancer_Homo sapiens_hsa052220.31718198
113Notch signaling pathway_Homo sapiens_hsa043300.30981142
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.29982717
115Gastric acid secretion_Homo sapiens_hsa049710.26954061
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26207895
117Melanogenesis_Homo sapiens_hsa049160.26118385
118Insulin secretion_Homo sapiens_hsa049110.24667764
119Hippo signaling pathway_Homo sapiens_hsa043900.24182715
120Renal cell carcinoma_Homo sapiens_hsa052110.22459983
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21956687
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21454278
123Metabolic pathways_Homo sapiens_hsa011000.19495615
124Circadian entrainment_Homo sapiens_hsa047130.18987166
125mTOR signaling pathway_Homo sapiens_hsa041500.16695569
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16385439
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15876341
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15473391
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15434505
130Platelet activation_Homo sapiens_hsa046110.15369158
131Pathways in cancer_Homo sapiens_hsa052000.15084176
132VEGF signaling pathway_Homo sapiens_hsa043700.14559936
133Toxoplasmosis_Homo sapiens_hsa051450.13212718
134Gap junction_Homo sapiens_hsa045400.12936503
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11816477
136Ovarian steroidogenesis_Homo sapiens_hsa049130.10755833
137Fat digestion and absorption_Homo sapiens_hsa049750.10113441
138Dorso-ventral axis formation_Homo sapiens_hsa043200.08631167
139GnRH signaling pathway_Homo sapiens_hsa049120.07984395
140Estrogen signaling pathway_Homo sapiens_hsa049150.07131936
141Tyrosine metabolism_Homo sapiens_hsa003500.05588180
142Rap1 signaling pathway_Homo sapiens_hsa040150.05543953
143Circadian rhythm_Homo sapiens_hsa047100.05312508
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.03355930

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